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Learn19791-1-AP
antibody from Proteintech Group
Targeting: BRCA2
BRCC2, FACD, FAD, FAD1, FANCD, FANCD1, XRCC11
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [15]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 19791-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19791-1-AP, RRID:AB_10638915
- Product name
- BRCA2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BRCA2 antibody (Cat. #19791-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Identification of a luminescent platinum(II) complex with BODIPY derivative as novel photodynamic therapy agent for triple negative breast cancer cells.
Antitumor efficacy of a recombinant EGFR-targeted fusion protein conjugate that induces telomere shortening and telomerase downregulation.
Combined BRCA2 and MAGEC3 Expression Predict Outcome in Advanced Ovarian Cancers.
FDI-6 and olaparib synergistically inhibit the growth of pancreatic cancer by repressing BUB1, BRCA1 and CDC25A signaling pathways.
Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA.
LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells.
FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair.
DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas.
SPAG5 upregulation contributes to enhanced c-MYC transcriptional activity via interaction with c-MYC binding protein in triple-negative breast cancer.
miR-1245a promotes the proliferation and invasion of colon adenocarcinoma by targeting BRCA2.
LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA.
A novel BRCA2 mutation in prostate cancer sensitive to combined radiotherapy and androgen deprivation therapy.
Flavone protects HBE cells from DNA double-strand breaks caused by PM2.5.
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy.
Wang Y, Wang S, Wang Q, Tang W, Lin L, Zhang T, Hu M, Wang X
Journal of inorganic biochemistry 2023 May;242:112160
Journal of inorganic biochemistry 2023 May;242:112160
Antitumor efficacy of a recombinant EGFR-targeted fusion protein conjugate that induces telomere shortening and telomerase downregulation.
Tao HY, He SM, Zhao CY, Wang Y, Sheng WJ, Zhen YS
International journal of biological macromolecules 2023 Jan 31;226:1088-1099
International journal of biological macromolecules 2023 Jan 31;226:1088-1099
Combined BRCA2 and MAGEC3 Expression Predict Outcome in Advanced Ovarian Cancers.
Omole EB, Aijaz I, Ellegate J Jr, Isenhart E, Desouki MM, Mastri M, Humphrey K, Dougherty EM, Rosario SR, Nastiuk KL, Ohm JE, Eng KH
Cancers 2022 Sep 28;14(19)
Cancers 2022 Sep 28;14(19)
FDI-6 and olaparib synergistically inhibit the growth of pancreatic cancer by repressing BUB1, BRCA1 and CDC25A signaling pathways.
Wu SQ, Huang SH, Lin QW, Tang YX, Huang L, Xu YG, Wang SP
Pharmacological research 2022 Jan;175:106040
Pharmacological research 2022 Jan;175:106040
Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA.
Wang C, Qu L, Li S, Yin F, Ji L, Peng W, Luo H, Lu D, Liu X, Chen X, Kong L, Wang X
Journal of medicinal chemistry 2021 Sep 9;64(17):12630-12650
Journal of medicinal chemistry 2021 Sep 9;64(17):12630-12650
LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells.
Chen BR, Wang Y, Tubbs A, Zong D, Fowler FC, Zolnerowich N, Wu W, Bennett A, Chen CC, Feng W, Nussenzweig A, Tyler JK, Sleckman BP
eLife 2021 Sep 3;10
eLife 2021 Sep 3;10
FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair.
Wang SP, Wu SQ, Huang SH, Tang YX, Meng LQ, Liu F, Zhu QH, Xu YG
Cell death & disease 2021 Dec 8;12(12):1138
Cell death & disease 2021 Dec 8;12(12):1138
DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas.
Holcomb AJ, Brown L, Tawfik O, Madan R, Shnayder Y, Thomas SM, Wallace NA
Virology 2020 Sep;548:174-181
Virology 2020 Sep;548:174-181
SPAG5 upregulation contributes to enhanced c-MYC transcriptional activity via interaction with c-MYC binding protein in triple-negative breast cancer.
Li M, Li A, Zhou S, Lv H, Yang W
Journal of hematology & oncology 2019 Feb 8;12(1):14
Journal of hematology & oncology 2019 Feb 8;12(1):14
miR-1245a promotes the proliferation and invasion of colon adenocarcinoma by targeting BRCA2.
Pan Z, Gan W, Liang C, Xiao Y, Zhang Y, Yang W, Hou Z, Chen S, Zeng B, Li Y
Annals of translational medicine 2019 Dec;7(23):777
Annals of translational medicine 2019 Dec;7(23):777
LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA.
Shen L, Wang Q, Liu R, Chen Z, Zhang X, Zhou P, Wang Z
Nucleic acids research 2018 Jan 25;46(2):717-729
Nucleic acids research 2018 Jan 25;46(2):717-729
A novel BRCA2 mutation in prostate cancer sensitive to combined radiotherapy and androgen deprivation therapy.
Liu Q, Tong D, Liu G, Yi Y, Xu J, Yang X, Wang L, Zhang J, Ye J, Zhang Y, Yuan G, Wang P, Chen R, Guan Y, Yi X, Zhang D, Jiang J
Cancer biology & therapy 2018 Aug 3;19(8):669-675
Cancer biology & therapy 2018 Aug 3;19(8):669-675
Flavone protects HBE cells from DNA double-strand breaks caused by PM2.5.
Ren X, Tang Y, Sun J, Feng J, Chen L, Chen H, Zeng S, Chen C, Li X, Zhu H, Zeng Z
Human cell 2018 Apr;31(2):116-126
Human cell 2018 Apr;31(2):116-126
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
Wang Y, Hu L, Zhang X, Zhao H, Xu H, Wei Y, Jiang H, Xie C, Zhou Y, Zhou F
Journal of Cancer 2017;8(8):1400-1409
Journal of Cancer 2017;8(8):1400-1409
The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy.
Wang Y, Wang Z, Qi Z, Yin S, Zhang N, Liu Y, Liu M, Meng J, Zang R, Zhang Z, Yang G
Molecular cancer 2014 Apr 28;13:94
Molecular cancer 2014 Apr 28;13:94
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 19791-1-AP(BRCA2 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BRCA2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human BRCA2. This antibody recognizes human antigen. The BRCA2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
