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- Antibody Data
- Antigen structure
- References [784]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
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- Product number
- 16001-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16001-1-AP, RRID:AB_2289842
- Product name
- Arginase-1 antibody
- Antibody type
- Polyclonal
- Description
- Arginase-1 antibody (Cat. #16001-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Photocrosslinkable Chitosan Quaternary Ammonium Salt-Based Ternary Hydrogel with Fibroblast Growth Factor 21 for Diabetic Wound Healing.
After Traumatic Brain Injury, EPHA4 Enhances Endoplasmic Reticulum Stress to Promote M1 Microglial Polarization Through the MAPK Signaling Pathway.
The mechanism of Vicenin-2 in ameliorating skin photoaging: involvement of m6A-modified macrophage polarization.
RP-182 alleviated obstruction-induced renal fibrosis by reprogramming CD206(+) macrophages.
GCDCA promotes hepatocellular carcinoma progression through S1PR2/PI3K/AKT-mediated polarization of M2-type macrophages.
CCL5 promotes angiotensin II-induced cardiac remodeling through regulation of platelet-driven M2 macrophage polarization.
A near-infrared regulated programmable multi-mode periosteum scaffold for sequential healing of infected bone defects.
PRSS23 functions downstream of ZEB1 to promote esophageal squamous cell carcinoma progression by driving M2 polarization of tumor associated macrophages.
Study on the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula by inhibiting M2 macrophage polarization and regulating TGF - β/SMAD signaling pathway.
Yinhuo Decoction attenuates depression-like behaviors and promotes M2 microglia polarization by regulating PI3K/Akt/NF-κB signaling pathway in a murine model of menopausal depression.
M2 macrophage-mediated tigecycline nanoparticles for combating CRKP pneumonia via antibacterial and immunomodulatory therapy.
Taohong Siwu decoction and its components regulate the M1/M2 polarization of macrophages to alleviate inflammatory injury in sepsis via the RAGE.
Macrophage AMPK activated by oxidative stress drives profibrotic crosstalk with tubular cells to accelerate renal fibrosis after ischemic and reperfusion injury.
Engineering multifunctional microspheres for sequential regulation of osteoimmune microenvironment and bone remodeling balance to promote regeneration of osteoporotic bone defects.
Dynamic ROS-responsive hyperbranched polymer-based neuroprotective drug delivery system for pathogenesis-adaptive sequential therapy of cerebral ischemic stroke.
Modulation of immune cell differentiation by Prunella vulgaris L. essential oil in pulmonary sarcoidosis treatment.
Early Radial Extracorporeal Shockwave Stimulation on Proximal Tibial Circular Osteotomy Site Enhanced Heterotopic Skin Wound Healing via Small Extracellular Vesicles.
Red Blood Cell-Derived Exosomes Deliver Complement C5 to Exacerbate Neuroinflammation and Neuronal Injury after Intracerebral Hemorrhage.
Glycogen Hydrogel Loaded with Schistosoma japonicas Peptide SJMHE1 Improves Skin Wound Healing.
ZXDB Drives Macrophage Inflammatory Programming in Sepsis-Induced Acute Kidney Injury by Recruiting EIF4A3 to Enhance ACACA Translation.
Vericiguat Attenuates Post-Myocardial Infarction Inflammation Associated With Macrophage Polarization and Regulation of the Survivin/Caspase-6 Pathway.
Cordycepin alleviates ischaemic brain injury by suppressing microglia-induced neuroinflammation via regulating the Notch1 signalling pathway.
Cancer cell-derived sialylated IgG interacting with Siglec-7/9/10 is a potential immunotherapeutic target in pancreatic cancer.
Tanshinone IIA-pretreated mesenchymal stem cells alleviate neuroinflammation in 3×Tg-AD mice via the TREM2/PI3K/Akt pathway.
ROS-Responsive Prodrug Containing Dihydroartemisinin and Cinnamaldehyde for the Potential Treatment of Nonalcoholic Steatohepatitis.
ROS-responsive hydrogels functionalized with Cu/Zn MOF targeting oxidative stress mitigation and inflammation modulation to promote spinal cord injury repair.
Exosomal lncRNA OTUD6B-AS1 as a pathogenic nanocarrier promotes inflammatory macrophage polarization in endometritis via a targetable ceRNA circuit.
Chaotrope-guided protein microneedles with high drug-loading capacity, ultrafast dissolution, and high mechanical strength.
Integrated whole transcriptome sequencing, network pharmacology and in vivo validation reveal that Compound Wufengcao Liquid promotes pressure injury healing via PPARγ-mediated macrophage polarization.
TREM2 activation suppresses central sensitisation by promoting autophagy in a chronic migraine model with recurrent nitroglycerin stimulation in mice.
Collagen-oxidized hyaluronic acid injectable self-healing hydrogel enabling sequential platelet-rich plasma release for microenvironment modulation in diabetic wound repair.
Engineered mesenchymal stem cell-derived extracellular vesicles attenuate acute glaucoma-induced neuroinflammation by reprogramming microglial polarization.
Kaiyujiangzhuo formula alleviates glycolipid metabolic disorders by improving arginine metabolism and inhibiting the ERK-mediated PPARγ-Ser273 phosphorylation.
Phyllanthin Targets GBP5 to Suppress Macrophage M1 Polarization and Alleviate DSS-Induced Colitis in a Murine Model.
Unraveling the therapeutic mechanisms of Polygonum cuspidatum in pulmonary fibrosis: Modulation of M2 macrophage polarization and glycolysis pathways.
Cu(2+)-chelated epigallocatechin gallate nanoparticle-functionalized hydrogel promotes osteogenesis by inhibiting ferroptosis.
Inhibition of endothelial ALOX12 mitigates cerebral ischemia-reperfusion injury by suppressing 12-HETE.
Scutebarbatine A inhibits M2 macrophage polarization via blocking PI3K/AKT signaling to impair cell stemness, metastasis, and angiogenesis in non-small cell lung cancer.
Methyl 3-chloroasterric acid exerted anti-neuroinflammatory and antidepressant effects through the downregulation of P2Y1R.
The role of the IL-33/ST2/MAPK signalling pathway in macrophage polarisation and endometrial fibrosis.
Diallyl Trisulfide Suppresses Tumor-Associated Macrophage M2-Like Polarization and Recruitment and Improves the Tumor Microenvironment Through Blocking CCL5/STAT3 Signaling Pathway Against Lung Cancer.
Targeting aldose reductase in pulmonary fibrosis: Blocking de novo fatty acid synthesis halts pro-fibrotic M2 polarization.
Adipose-derived stem cells (ADSCs)-derived DKK1 promotes cutaneous wound healing by inducing M2 macrophage polarization via PI3K/AKT and JNK activation.
Impaired nitrogenous waste clearance promotes hepatocellular carcinoma.
Integrating single cell- and spatial- resolved transcriptomics unravels the inter-tumor heterogeneity and immunosuppressive landscape in HBV- and Clonorchis sinensis-associated hepatocellular carcinoma.
Ptbp2 Alleviates Neuroinflammation and Blood-brain Barrier Disruption via Modulating Microglial Polarization in Ischemic Stroke.
Anti-tumor effect of flavonoids isolated from Bidens Pilosa L. by regulating the activity of myeloid-derived suppressor cells within the tumor microenvironment in mice.
Rewiring brain structural and functional disconnection with acupuncture in rat model of vascular cognitive impairment and dementia.
Caveolin-2 Knockdown Alleviated Sepsis-induced Acute Lung Injury Via Promoting Macrophage M2 Polarization and Inhibiting Apoptosis by Hippo Signaling Pathway.
E3 ubiquitin ligase trim36 targets ddx3x for degradation to reprogram macrophage polarization and ameliorate tubal factor infertility in rats.
Functional remodeling of iNKT cells by sulfatide-reactive type II NKT cells reprograms alveolar macrophages to alleviate lung ischemia-reperfusion injury.
Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation.
Acupuncture as a modulator of microglial polarization and pyroptosis in depression: evidence from a chronic unpredictable mild stress rat model.
Mechanistic insights into the effects of Norisoboldine on intestinal immunity and neuroinflammation in a mouse model of slow transit constipation with depression.
CXCL9- preconditioned BMSCs attenuate rat post-traumatic osteoarthritis by modulating synovial macrophage polarization via the TLR2/TGF-β2 signaling pathway.
Dissecting macrophage heterogeneity in ulcerative colitis: Single-cell analysis and functional validation of S100A4 as a therapeutic target.
STING deficiency alleviates ischemia-reperfusion injury via JAK2/STAT3-mediated macrophage polarization and autophagy.
Developmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition.
Ascorbate elastomer-coated ePTFE grafts inhibit neointimal hyperplasia and enhance vascular healing.
Transcutaneous Auricular Vagus Nerve Stimulation Ameliorates Heart Failure with Preserved Ejection Fraction Through Regulating Macrophage Polarization Mediated by Alpha7nAChR.
Targeted inflammatory microenvironment remodeling and NIR-II photothermal therapy for abdominal aortic aneurysm.
Pressure-sensitive composite bandages with high toughness, self-healability and strong tissues adhesion for rapid bone fixation and accelerated osteogenesis via immunomodulation and neovascularization.
4D-printed Fe3O4-PLLA scaffolds modulate osteoimmune microenvironment for oral bone repair.
Omentin-1 promotes diabetic wound healing by regulating macrophage efferocytosis and M2 polarization.
Self-adaptive covalent coating for vascular stents: Coordinated coagulation-inflammation regulation to support re-endothelialization for atherosclerosis control.
Lycium barbarum Polysaccharide Alleviates Renal Damage in Mouse Sepsis by Regulating M1/M2 Macrophage Polarization.
Reducing Neuroinflammation via Inhibition of Fibrinogen Deposition and Microglial Activation as an Underlying Mechanism of Paning I Decoction in Ameliorating Parkinson's Disease Symptoms.
Inhalation of mesenchymal stromal cell-derived extracellular vesicles activates macrophage polarization through the miR-22-3p/NLRP3/IL-1β pathway, ameliorating lung ischemia - reperfusion injury.
ICAM2 loss drives 5-fluorouracil resistance via TGF-β/Smad/SP1/PTN-dependent apoptosis evasion and macrophage remodeling in gastric cancer.
Treadmill running modulates infrapatellar fat pad remodeling in osteoarthritic rats in an intensity-dependent manner.
TRPV1 manipulating polarization of M1/M2 macrophages to promote skeletal muscle regeneration.
Succinate Mediates Immune-Angiogenic Response by Activating Macrophage M2 Polarization in Oxygen-Induced Retinopathy.
Integration of Bulk and Single-Cell Transcriptomics Reveals Prognostic and Immunological Roles of MTHFD2 in Clear Cell Renal Cell Carcinoma.
Phosphoglycerate dehydrogenase-mediated serine reprogramming aggravates macrophage hyperinflammation in murine Pseudomonas aeruginosa pneumonia.
AIF-1 Drives Corneal Neovascularization by Promoting Inflammatory Macrophage Activation via the MAPK and PI3K/AKT/mTOR Signaling Pathways.
The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation.
Ultraviolet-induced Glycyrrhiza polysaccharide hydrogels with different mechanical strength for wound management.
Luteolin-Loaded TGN/RAP12 Dual-Peptide Functionalized Nanoparticles: Synergistic Enhancement of BBB Penetration and Microglia Targeting in Alzheimer's Disease.
Houttuynia cordata Polysaccharide Alleviates Hepatic Ischemia-Reperfusion Injury by Regulating Macrophage Polarization via Inhibiting the TLR4/NF-κB Signaling Pathway.
An immunomodulatory hydrogel featuring antibacterial and ROS-scavenging functions for enhanced burn wound healing.
Jianpi-huayu Decotion regulates TREM1/DAP12 pathway to improve the immunosuppressive tumor microenvironment and enhance the anti-hepatocellular carcinoma effect of PD-1 inhibitors.
Hypoxia-preconditioned cardiomyocyte-derived extracellular vesicles alleviate myocardial ischemic injury by reprogramming macrophage polarization via the Fgl2/NF-κB pathway.
Sensory neuron TRPV1-mediated macrophage polarization and immune response regulate dental implant osseointegration.
Bacteria-responsive DNAgel system for targeted delivery of photothermally enhanced MXene/MoS(2) in the treatment of pyogenic osteomyelitis.
Mesoporous bioactive glass hybrid nanoparticles accelerate tendon-bone healing via synergistic angiogenesis and immunomodulation.
MicroRNA-493-5p engineered exosomes delivered via piezoelectric microneedles for epigenetic modulation of macrophages in diabetic wound healing.
Dual-responsive PDA-HP hydrogel enables mitochondria-targeted mild photothermal therapy for spinal cord repair.
Expanded screening and analysis of Photorhabdus virulence cassette (PVC) signal peptides reveals an anti-phagocytotic effector.
ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.
The Dual Role of Gastrodin in Spinal Cord Injury: Microglial Phenotype Switching and Neuronal Survival via PI3K/AKT Activation.
Wine-Processed Cornus officinalis Ameliorates Osteoarthritis via Modulating M1/M2 Macrophage Polarization.
RUVBL2 Regulates Microglia Metabolic Reprogramming to Mediate Stress Granules Aggregation Exacerbating Postoperative Delirium in Aged Mild Cognitive Impairment Rats.
Parthenolide ameliorates inflammation in sepsis via covalently targeting Trim33 and inhibiting NF-κB pathway.
Zinc-Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing.
Hierarchical Targeting of TREM2(+) Myeloid Cells via Acid-Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone-Metastatic TNBC.
Longitudinal Single-Cell RNA-seq Profiling of Lung Cell Phenotypes, Signaling, and Cross-talk During Fibrosis Resolution.
Ubiquitously expressed prefoldin-like chaperone (UXT) regulates putrescine metabolism and promotes colorectal cancer progression.
Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1-Mediated M1 Macrophage Polarization in Sarcoidosis.
Shionone Alleviates Sepsis-Induced Acute Lung Injury by Regulating Macrophage Polarization Through the HMGB1/NF-κB Pathway.
Xuming tongmai decoction modulates astrocyte polarization and mitophagy via the PINK1/Parkin pathway in a rat model of acute ischemic stroke.
Ginsenoside Rg3 synergizes with near-infrared photothermal therapy to suppress prostate cancer progression by inhibiting RAS signaling and enhancing ARL11-mediated macrophage reprogramming.
Platelet factors 4 produces an antidepressant effect in mice via inhibition of neuroinflammation.
Targeting Smad3 Phosphorylation Attenuates Anastomotic Intimal Hyperplasia and Perigraft Fibrosis in Decellularized Tissue-Engineered Vascular Grafts.
Ginsenoside Rh2-Pretreated Mesenchymal Stem Cell Exosomes Ameliorate Collagen-Induced Arthritis via N6-Methyladenosine Methylation.
WTAP Maintains Alternative Activation of Macrophages by Promoting IDH1-Mediated α-ketoglutarate Production.
Orphan Class A GPCRs Signature Predicts Prognosis and Immune Microenvironment in Gastric Cancer: GPR176 Drives Tumor Progression Through Wnt Signaling and Macrophage Polarization.
Electroacupuncture Improves Ovarian Function in Rats With Tripterygium Glycoside-Induced Diminished Ovarian Reserve by Promoting the Polarization of M2 Macrophages and Inhibiting Inflammatory Responses.
Parthenolide regulates microglial and astrocyte function in primary cultures from ALS mice and has neuroprotective effects on primary motor neurons.
Heme Oxygenase-1 Modulates Macrophage Polarization Through Endothelial Exosomal miR-184-3p and Reduces Sepsis-Induce Lung Injury.
Lung Tissue Extracellular Vesicles-Mediated Delivery of miR-128-3p as a Novel Mechanism of Acute Lung Inflammation.
Quercetin-Loaded Nanoparticle-Modified Decellularized Tissue-Engineered Vascular Graft Regulates Macrophage Polarization and Promotes In Vivo Graft Remodeling.
Tenascin-C Facilitates Microglial Polarization via TLR4/MyD88/NF-κB Pathway Following Subarachnoid Hemorrhage.
A stage specific NETs-related signature in alcoholic steatohepatitis: from molecular subtyping to therapeutic vulnerabilities.
MCP-1/CCR2 axis regulates M2 macrophage polarization and immunosuppression in mycobacterium tuberculosis.
Bone marrow mesenchymal stem cells alleviate smoke inhalation injury by regulating alveolar macrophage polarization via the CD200-CD200R pathway.
Machine learning identifies PYGM as a macrophage polarization-linked metabolic biomarker in rectal cancer prognosis.
Integrative analysis of single-cell and microarray data reveals SPI1-centered macrophage regulatory signatures in ulcerative colitis.
miR-223 alleviates DSS-induced colitis by prompting macrophage M2 polarization through PPAR-γ/FOXO1 signaling.
Hsa_circ_0058495-mediated IGF2BP2 ubiquitination and m6A modification of MEKK1 promote the progression of PDAC.
Lysyl Oxidase-Like 1 (LOXL1) Up-Regulation in Chondrocytes Promotes M1 Macrophage Activation in Osteoarthritis via NF-κB and STAT3 Signaling.
The Effects of M2 Macrophages-Derived Exosomes on Urethral Fibrosis and Stricture in Scar Formation.
Decoding HuH-7: a comprehensive genetic and molecular portrait of a widely used hepatocellular carcinoma model.
The role of astrocyte-derived extracellular vesicles in cellular microenvironment remodeling after spinal cord injury: A study based on quantitative proteomics analysis.
Regulation of macrophage phenotypes via NF-κB/NLRP3 and HIF1α/p53 pathways by fuco-galactoglucan from Agrocybe aegerita.
Mycobacterium tuberculosis impairs protective cytokine production via transcription factor MafB manipulation.
Effects of SADS-CoV accessory proteins NS3a, NS7a, and NS7b on viral pathogenicity: A multi-omics investigation.
Piezoelectric-IL-4 programmed regulation of immuno-microenvironment-induced mesenchymal stem cell recruitment and differentiation for bone regeneration.
A Myelin Debris Cleaner for Spinal Cord Injury Recovery: Polycaprolactone / Cell Membrane Assembled Scaffolds.
Multidimensional Engineering of Extracellular Vesicles for Targeted Delivery and Microglial Reprograming in Spinal Cord Injury Repair.
Inhibition of Dectin-1 alleviates inflammation in early diabetic retinopathy by regulating microglia phenotype.
METTL14 knockdown augmented the polarization of M2-like macrophages to promote acute myeloid leukemia progression.
Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling.
Rhodiola tangutica (maxim.) S. H. Fu protects blood-retinal barrier in hypoxia-induced retinal injury rats by down-regulating HIF-1α/eNOS/NO pathway.
Breviscapine regulates lipid metabolism of microglia via the ADORA1/PPARα/ACOX1 pathway to promote spinal cord injury recovery.
Vitamin D against diabetic adipose tissue inflammation through SHP-1/STAT3 pathway.
Artesunate suppresses ocular inflammation in endotoxin-induced uveitis through inhibiting the NF-κB signaling pathway and M1 macrophage polarization.
Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice.
Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.
Catalyst-modulated hydrogel dynamics for decoupling viscoelasticity and directing macrophage fate for diabetic wound healing.
One-step strategy for fabricating icariin-encapsulated biomimetic Scaffold: Orchestrating immune, angiogenic, and osteogenic cascade for enhanced bone regeneration.
On-Demand ER Stress Modulation in Tumor Cells and TAMs via an Adaptively Transformable Nanoplatform Enhances Photodynamic Immunotherapy.
Dual stimulus-responsive dECM cryogel sequentially regulate bone microenvironment for one-step surgical therapy of chronic osteomyelitis.
A multifunctional self-assembled hydrogel with bactericidal activity and macrophage metabolic reprogramming for diabetic bone defect repair.
Chiral gold nanoparticles manipulate osteoimmune microenvironment via macrophage autophagy for bone regeneration.
Translating m6A-Glycolysis Discovery into Therapy: GOQD-Based Multifunctional Bioactive Scaffolds Rejuvenates Bone Repair in Senescence.
From Molecular Docking to Rat Models: Butyrate From a High-Fiber Diet Inhibits HDAC1 and NLRP3 Inflammasome to Alleviate Oxidative Stress and Inflammation After Spinal Cord Injury.
miR-21-5p Alleviates Retinal Ischemia-Reperfusion Injury by Inhibiting M1 Polarization of Microglia via Suppression of STAT3 Signaling.
Dental pulp stem cells promote the recovery of spinal cord injury by regulating microglia polarization via JAK2/STAT3 signaling pathway.
MYCN-mediated pyroptosis and inflammation in the molecular mechanism of MicroRNA-202-3P promote functional recovery in spinal cord injury.
Synergistic potential of Berberine and Wogonin improved adipose inflammation and insulin resistance associated with obesity through HIF-α axis.
Amelioration of renal injury by Qihuang Jianpi Zishen Granules in lupus mice is correlated with AMPK/ULK1-dependent modulation of macrophage polarisation.
Mesenchymal stem cell extracellular vesicles ameliorate radiation-caused dry mouth via modulating immune balance and cell metabolism.
M2-exo promote orthodontic bone remodeling via the MeCP2-TCF20-HDAC1 axis.
A cell-free TLR5(high) MSC membrane nanoparticle therapy for Crohn's disease: Targeted immunomodulation via the flagellin/TLR5 axis.
Fe-MOF loaded with capmatinib to reverse immunosuppressive microenvironment and inhibit tumor metastasis after radiofrequency ablation.
TFAP4/DLGAP5 promotes tumor progression and macrophage M2 polarization in prostate cancer by activating the JAK2/STAT3 signaling.
Effects of Sapropterin against Non-Alcoholic Fatty Liver Disease in mice.
Characterization of Periplaneta americana glycoproteins' structures and their potential to treat immunological liver fibrosis.
Innovative DNA tetrahedron inspired by ancient mortise-and-tenon technique offers new immunotherapy strategy for metastatic breast cancer.
Galectin-9 promotes colon cancer development by polarizing macrophages toward the M2 phenotype.
Interleukin-10 Modified Human Mesenchymal Stromal Cells Markedly Alleviated Periodontitis by Inducing Macrophage M2 Polarisation.
TAS4464, a neddylation inhibitor, mitigates Staphylococcus aureus-induced periprosthetic joint infection by modulating immunosuppressive cell functions.
AMPK upregulates SOCS1 to promote TFEB nuclear transfer, enhances autophagy, inhibits macrophage M1 polarization and relieves acute lung injury.
eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR-Mediated Metabolic Rewiring.
RRBP1 Inhibition Reduces Microglial M1 Polarization and Inflammation-Mediated Neuronal Loss and Oxidative Stress by Regulating ERK Pathway in Alzheimer's Disease.
A mitochondria-targeted nanomedicine for myocardial ischemia/reperfusion injury with synergistic antioxidant and anti-inflammatory properties.
Rg1-preconditioned adipose-derived mesenchymal stromal cells alleviate colitis via exosome-mediated Inhibition of macrophage glycolysis through RAS signaling.
The Leupaxin/HDAC6/EGR2 axis facilitates breast cancer progression by enhancing macrophage M2 polarization.
Urolithin B promotes the functional recovery of spinal cord injury by alleviating neuroinflammation via the inhibition of NLRP3 signaling pathway.
M2 macrophages and tumor cells engage in a metabolic feedback loop to drive HCC progression.
The miR-125a-5p/IRF4 Axis Mediates Sodium Arsenite-Induced M2 Macrophage Polarization.
Gallic Acid Alleviates Cerebral Ischemia-reperfusion Injury in Mice by Mediating Microglial Polarization Through the NLRP3/mTOR Axis.
Application of Dental Pulp Stem Cell-Derived Intracellular Vesicles for Diabetic Wound Healing.
Ultrasound-triggered injectable piezoelectric nanocomposite hyaluronic acid-based hydrogel for modulating inflammation and chondrogenesis in osteoarthritis treatment.
Hydroxysafflor yellow A attenuates the blood-brain barrier dysfunction and neuroinflammation through anti-inflammatory microglial polarization after intracerebral hemorrhage.
Th22 cells promote the transition from homeostatic to reactive microglia in diabetic encephalopathy.
Succinate Activates Uncoupling Protein 2 to Suppress Neuroinflammation and Confer Protection Following Intracerebral Hemorrhage.
Dectin-1 participates in neuroinflammation and dopaminergic neurodegeneration through synergistic signaling crosstalk with TLR4.
Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization.
Enhancing Tendon Regeneration: Investigating the Impact of Topography on the Secretome of Adipose-Derived Stem Cells.
GTS-21 alleviates sepsis-induced atrial fibrillation susceptibility by modulating macrophage polarization and Neuregulin-1 secretion.
Comparison of the Immunomodulatory Roles of Porcine Milk-Derived Extracellular Vesicles from Different Stages of Lactation.
Toxoplasma calcium-dependent protein kinases 3 mediates M1 macrophage polarization by targeting host Arginase-1.
Herkinorin ameliorates neuronal damage in a pentylenetetrazol-induced epilepsy rat model through altering microglial and astrocytic activation by inhibiting PARP1 and NF-κB.
IL-27 accelerates diabetic wound healing by modulating macrophage polarization.
Astragaloside IV prevents liver fibrosis by blocking glycolysis-mediated macrophage M1 polarization.
Anemarrhena asphodeloides Bunge and Phellodendri Chinensis Cortex inhibits the PTGS2/EP2/cAMP/Epac1 signaling pathway to reduce microglial M1 polarization, thereby blocking chronic stress-induced depression-like behavior.
Baicalin prevents experimental autoimmune uveitis by promoting macrophage polarization balance through inhibiting the HIF-1α signaling pathway.
CKIP-1 inhibits M2 macrophage polarization to suppress the progression of gastric cancer by inactivating JAK/STAT3 signaling.
DANCR knockdown alleviates neuroinflammation and functional recovery after spinal cord injury via regulating the ACTN4 / STAT3 axis.
ISRIB facilitates post-spinal cord injury recovery through attenuation of neuronal apoptosis and modulation of neuroinflammation.
Suppression of Sepsis Cytokine Storm by Escherichia Coli Cell Wall-Derived Carbon Dots.
Early intervention with pericyte Fli-1 post-TBI attenuates hippocampal BBB disruption and subsequent neuroinflammation with neurological deficits.
Screening effective-component compatibility from Jinshui Chenfei formula for silicosis treatment by serum-pharmacochemistry and feedback system control.
Exploring the active components and potential mechanisms of Zhimu-Huangbai herb-pair in the treatment of depression.
Adropin-Driven Browning: Targeting M2 Macrophages to Combat PCOS.
Indole-3-Propionic Acid Attenuates Neuroinflammation and Cognitive Deficits by Inhibiting the RAGE-JAK2-STAT3 Signaling Pathway.
Luteolin modulates liver macrophage subtype polarization and play protective role in sepsis induced acute hepatic injury.
Mechanism of action of Danlou tablets affecting MAFLD via KEAP1-mediated oxeiptosis.
Berberine Exerts Neuroprotective Effects in Alzheimer's Disease by Switching Microglia M1/M2 Polarization Through PI3K-AKT Signaling.
Intranasal delivery of engineered extracellular vesicles promotes neurofunctional recovery in traumatic brain injury.
Activated NETosis of bone marrow neutrophils up-regulates macrophage osteoclastogenesis via cGAS-STING/AKT2 pathway to promote osteoporosis.
Corilagin enhances wound healing by modulating the macrophage phenotype in diabetic mice.
LXRα agonists ameliorates acute rejection after liver transplantation via ABCA1/MAPK and PI3K/AKT/mTOR signaling axis in macrophages.
Brown adipose tissue transplantation ameliorates hindlimb ischemic damage in diabetic mice.
GHSR gene knockout alleviates the liver pathological response in Echinococcus granulosus infection by reducing parasite survival.
Static Topographical Cue Combined with Dynamic Fluid Stimulation Enhances the Macrophage Extracellular Vesicle Yield and Therapeutic Potential for Bone Defects.
Folate-targeted nanoparticles for glutamine metabolism inhibition enhance anti-tumor immunity and suppress tumor growth in ovarian cancer.
LCN2 Regulates Microglia Polarization Through the p38MAPK-PGC-1α-PPARγ Pathway to Alleviate Traumatic Brain Injury.
Myelination Trajectory and Microglial Dynamics Following Repeated Sevoflurane Exposure in Developing Brain.
Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Through the Promotion of Type 2 Macrophage Polarization.
Injectable bioresponsive bone adhesive hydrogels inhibit NLRP3 inflammasome on demand to accelerate diabetic fracture healing.
miR-301a-5p regulated IKKβ/NF-κB axis and macrophage polarization to accelerate skin wound healing.
Gallic acid promotes M2 macrophage polarization through mitochondrial oxidative phosphorylation in periodontitis.
TGF-β1 induces autophagy and mediates the effect on macrophages differentiation in primary liver cancer.
Malvidin Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Modulating JAK2/STAT3 Signaling to Inhibit Macrophage M1 Polarization and Oxidative Stress.
N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia/macrophage via the AMPK-PGC1α-PPARγ pathway to promote recovery in mice with spinal cord injury.
GDF15 suppresses abdominal aortic aneurysm by upregulating AREG expression to adjust macrophage polarization.
ISCU-p53 axis orchestrates macrophage polarization to dictate immunotherapy response in esophageal squamous cell carcinoma.
Human Amniotic Fluid-Derived Exosomes Alleviate Neuropathic Pain by Inducing an Anti-Inflammatory Transition in Microglia.
Tailored "Three-stage booster" nano-extinguisher for synergistic treatment of severe acute pancreatitis by rectifying mitochondrial dysfunction and inhibiting pancreatic autodigestion.
Sirt5-mediated polarization and metabolic reprogramming of macrophage sustain brain function following ischemic stroke.
Fate reversal: Exosome-driven macrophage rejuvenation and bacterial-responsive drug release for infection immunotherapy in diabetes.
Secretome enriched with small extracellular vesicles derived from human gingiva-derived mesenchymal stem cells enhances rat tongue muscle regeneration.
GDF11 Regulates M1 and M2 Polarization of BV2 Microglial Cells via p38 MAPK Signaling Pathway.
Immune-modulated adhesive hydrogel for enhancing osteochondral graft adhesion and cartilage repair.
Methacrylated sericin/methacrylated hyaluronic acid composite microneedles with exosomes for diabetic wound healing.
Bacillus paralicheniformis-mediated gut microbiota promotes M2 macrophage polarization by inhibiting P38 MAPK signaling to alleviate necrotizing enterocolitis and apoptosis in mice.
Optimally Aligned Nerve Scaffolds with Sustained Astaxanthin Release Improve the Inflammatory Microenvironment through Mitophagy Activation.
p16INK4a downregulation alleviates temporomandibular joint osteoarthritis combined with type 2 diabetes by driving M2 polarization.
DPSCs modulate synovial macrophage polarization and efferocytosis via PINK1/Parkin-dependent mitophagy.
Macrophage EP4 Deficiency Drives Atherosclerosis Progression via CD36-Mediated Lipid Uptake and M1 Polarization.
Rhein Inhibits Microglia-Mediated Neuroinflammation and Neuronal Damage of Alzheimer's Disease via Regulating the Glutamine-Aspartate-Arginine-NO Metabolic Pathway.
Salvianolic Acid B Attenuates Liver Fibrosis via Suppression of Glycolysis-Dependent m1 Macrophage Polarization.
Targeted Inhibition of Aldose Reductase by Isoliquiritigenin Suppresses Fatty Acid Synthesis to Inhibit Macrophage M2 Polarization and Alleviate Pulmonary Fibrosis.
Pan-cancer human brain metastases atlas at single-cell resolution.
S100a4(+) alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism.
MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization.
Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzheimer's disease by activating the Wnt/β-catenin signaling.
ROS Responsive Cerium Oxide Biomimetic Nanoparticles Alleviates Calcium Oxalate Crystals Induced Kidney Injury via Suppressing Oxidative Stress and M1 Macrophage Polarization.
Inhibition of PKM2 by shikonin impedes TGF-β1 expression by repressing histone lactylation to alleviate renal fibrosis.
Pimpinellin mitigates DSS-induced ulcerative colitis in mice by reducing inflammation and regulating gut microbiota.
Ginsenoside RK3 inhibits glioblastoma by modulating macrophage M2 polarization via the PPARG/CCL2 axis.
Matrix Metalloproteinase-Responsive Controlled Release of Self-Assembly Nanoparticles Accelerates Heart Valve Regeneration In Situ by Orchestrating Immunomodulation.
Viscoelastic Hydrogel Modulates Phenotype of Macrophage-Derived Multinucleated Cells and Macrophage Differentiation in Foreign Body Reactions.
Zuojin Wan Suppresses the Progression of Colorectal Cancer by Inhibiting M2 Tumor-Associated Macrophages Through JAK2/STAT3 Signaling Pathway and In Vivo and In Vitro.
Inhibition of macrophage polarization and pyroptosis in collagen-induced arthritis through MSC-exo and ginsenoside Rh2.
A Disintegrin and Metalloproteinase 17 Disrupts Bovine Macrophage MER Proto-Oncogene Tyrosine Kinase Integrity to Impede Apoptotic Cell Clearance and Promote Inflammation in Clinical Mastitis.
SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia.
ANGPTL4 induces Kupffer cell M2 polarization to mitigate acute rejection in liver transplantation.
Natural phenol carbamates: Selective BuChE/FAAH dual inhibitors show neuroprotection in an Alzheimer's disease mouse model.
Lemon-derived nanoparticle-functionalized hydrogels regulate macrophage reprogramming to promote diabetic wound healing.
Total alkaloids in Fritillaria cirrhosa D. Don alleviate OVA-induced allergic asthma by inhibiting M2 macrophage polarization.
Multi-platform analysis revealed the substance basis and mechanism of Wei-Tong-Xin in ameliorating ENS dysfunction for dyspepsia treatment.
Nitric Oxide-Releasing Mesoporous Hollow Cerium Oxide Nanozyme-Based Hydrogel Synergizes with Neural Stem Cell for Spinal Cord Injury Repair.
Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression.
Zinc-induced photocrosslinked konjac glucomannan/glycyrrhizic acid hydrogel promotes skin wound healing in diabetic mice through immune regulation.
Luteolin modulates macrophage phenotypic switching via the AMPK-PPARγ pathway to alleviate ulcerative colitis in mice.
Hepatoma cell-derived exosomal SNORD52 mediates M2 macrophage polarization by activating the JAK2/STAT6 pathway.
Dentin tubules as a long-term sustained release carrier to accelerate bone repair by loading FTY720.
A reactive oxygen species-responsive hydrogel loaded with Apelin-13 promotes the repair of spinal cord injury by regulating macrophage M1/M2 polarization and neuroinflammation.
Hyperactivity of the IL-33-ILC2s-IL-13-M-MDSCs axis promotes cervical cancer progression.
N 6-Methyladenosine Demethylase FTO Controls Macrophage Homeostasis in Diabetic Vasculopathy.
Macrophage metabolic reprogramming ameliorates diabetes-induced microvascular dysfunction.
β-Catenin mediated TAM phenotype promotes pancreatic cancer metastasis via the OSM/STAT3/LOXL2 axis.
RBPJ Knockdown Promotes M2 Macrophage Polarization Through Mitochondrial ROS-mediated Notch1-Jagged1-Hes1 Signaling Pathway in Uveitis.
Intra-cisterna-magna bevacizumab injection (ICM-BI) reproduces pathological alterations of cerebral small vessel diseases.
Astragaloside IV Alleviates Acute Hepatic Injury by Regulating Macrophage Polarization and Pyroptosis via Activation of the AMPK/SIRT1 Signaling Pathway.
Nasal mucosal mesenchymal stem cells promote repair of sciatic nerve injury in rats by modulating the inflammatory microenvironment.
Citrulline Plus Arginine Induces an Angiogenic Response and Increases Permeability in Retinal Endothelial Cells via Nitric Oxide Production.
Dapagliflozin alleviated seizures and cognition impairment in pilocarpine induced status epilepticus via suppressing microglia-mediated neuroinflammation and oxidative stress.
MiR-186-5p carried by M2 macrophage-derived exosomes downregulates TRPP2 expression in airway smooth muscle to alleviate asthma progression.
Circular RNA APP contributes to Alzheimer's disease pathogenesis by modulating microglial polarization via miR-1906/CLIC1 axis.
Eu-Doped TiO(2) Coatings via One-Step In Situ Preparation Enhance Macrophage Polarization and Osseointegration of Implants.
Intelligent sequential degradation hydrogels by releasing bimetal-phenolic for enhanced diabetic wound healing.
Indirubin regulates M1/M2 polarization and inhibits ferroptosis in dextran sulfate sodium induced colitis and in cultured THP-1 cells.
Nano MgO loaded thermosensitive HPCH@HA hydrogel accelerates in situ bone repair through osteoimmunomodulation while enhancing angiogenesis and osteogenesis.
Exosome-mediated perturbation of the immune-bone metabolism axis: a mechanistic investigation into bone loss in a simulated microgravity environment.
Genetic Ablation of miR-146a Induces Abdominal Aortic Aneurysm Formation by Intensifying Inflammatory M1-Like Macrophages Polarization and Vascular Smooth Muscle Cell Phenotypic Switching.
PUFAs-enriched oil bodies as natural anti-osteoarthritis drug delivery platforms.
Whitlockite-loaded silk fibroin/polyvinyl alcohol hydrogel composited with porous tantalum scaffold enhances bone regeneration and immunomodulation via the TGF-β/NRROS signaling pathway.
Silicified strontium-curcumin chelated nanospheres mitigate inflammatory vicious cycles to accelerate diabetic wound healing.
A dual-drug sequential delivery hydrogel for programmatic microglia/macrophage polarization and function recovery in spinal cord injury.
Deoxycholic Acid and Lipoteichoic Acid cooperatively drive macrophage M2/M1 polarization via TGR5/STAT3 and TLR2/NF-κB to fuel HCC progression in obesity.
MicroRNA-3473b regulates corticosterone-induced microglial polarization and inflammation through TREM2.
Injury-induced Clusterin(+) cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages.
Microglia-specific interleukin-4 delivery by engineered extracellular vesicles restores inner blood-retinal barrier in diabetic retinopathy via GAS6-MERTK pathway.
MSC administration resolves experimental acute gout increasing specialized pro-resolving mediators synthesis through a super-induction of prostaglandin E(2).
Enhanced therapeutic efficacy of repeated bone marrow-derived MSC administration in a murine model of pulmonary fibrosis.
Ectomesenchymal Stem Cell Transplantation Induces Microglial Polarization and Anti-inflammatory IL-10 Secretion via NF-κB and MAPK Pathways to Mitigate Brain Injury Post-cerebral Hemorrhage.
Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling.
Genistein ameliorates non-alcoholic fatty liver disease in mice by modulating gut microbiota and hepatic macrophage polarization.
Astragaloside IV improves cognitive impairment in diabetes by inhibiting calpain-1/NLRP3 mediated microglial activation.
Calcineurin/NFAT1/Smad2 signaling regulates microglial autophagy that contributes to neuroinflammation and cognitive deficit in mice with sepsis-associated encephalopathy.
Xuebijing inhibits alveolar macrophage M1 polarization by regulating ROS-mediated NLRP3 inflammasome signaling.
Sequential simulation of regeneration-specific microenvironments using scaffolds loaded with nanoplatelet vesicles enhances bone regeneration.
Irisin Alleviates Autoimmune Uveitis Through Promoting Retinal Microglial M1 to M2 Phenotypic Polarization Mediated by HIF-1α Pathway.
Triamcinolone Acetonide Protects Against Light-Induced Retinal Degeneration by Activating Anti-Inflammatory STAT6/Arg1 Signaling in Microglia.
Rescuing inflammatory microenvironment induced senescence via MgO immune mediated asymmetric short fibers for accelerating diabetic wound repair.
Polyphenol-based self-assembled nanoparticles treating uveitis by inflammation-oxidative stress suppression.
Electroacupuncture Improves Microglial Polarization Induced-Inflammation by Regulating the TGF-β/Smad-3 Signaling Pathway in Ischemic Stroke Mice.
Black phosphorus nanosheets promote neuronal differentiation of neural stem cells through adhesion and pinocytosis for spinal cord injury repair.
SAA1 deletion ameliorates cardiac injury after myocardial infarction by promoting macrophage transformation to reparative subtype.
Layered double hydroxide-delivered si-NEAT1 inhibits breast cancer immune evasion and malignant progression by modulating the miR-141-3p/PD-L1 axis.
Improved prebiotic-based "shield" equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota.
Exosomal miR-218 secreted from endothelial progenitor cells mitigates acute lung injury in sepsis mice by inhibiting HMGA1 in alveolar macrophages.
Identification of the role of ARG1 in the fibrotic process of benign airway stenosis using bioinformatics analysis.
Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice.
Preventive and therapeutic effects of Tanshinone IIA on spinal cord injury without radiographic abnormality by regulating microglial phenotype polarization.
Lovastatin alleviates DSS-induced colitis by modulating macrophage polarization via the PPARγ-NF-κB pathway.
Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer.
USP18 promotes ferroptosis in lipopolysaccharide-induced human kidney organoids by stabilizing STING1.
Sanren decoction ameliorates ulcerative colitis by modulating gut microbiota and macrophage polarization to enhance intestinal barrier function.
MRO/HNRNPU/CCL5 feedback loop amplifies M2 macrophage and breast cancer cell crosstalk to drive progression.
Urea cycle dysregulation drives metabolic stress and neurodegeneration in Parkinson's disease.
Interleukin-6 enhances localized immune cell infiltration and deep vein thrombosis resolution at the distal edge.
Functional anti-inflammatory mesoporous silica nanoplatform for Synergistic and Targeted abdominal aortic aneurysm treatment.
Dexmedetomidine Improves Long-term Neurological Outcomes by Promoting Oligodendrocyte Genesis and Myelination in Neonatal Rats Following Hypoxic-ischemic Brain Injury.
Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways.
MYCN/MNX1 Axis Drives NSCLC Progression by Inducing Macrophage M2 Polarization and CD8(+) T Cell Apoptosis via the Wnt/β-Catenin Pathway.
Implantation of MSC spheroid-derived 3D decellularized ECM enriched with the MSC secretome ameliorates traumatic brain injury and promotes brain repair.
Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair.
Exosome-loaded tannic acid-thioctic acid hydrogel enhances wound healing in coagulation disorders.
An injectable responsive exosome-releasing hydrogel based on sodium alginate restores motor and bladder function by alleviating the injury microenvironment and facilitating distal nerve repair.
Strontium-based quaternary ammonium salt chitosan particles for ultrafast hemostasis of open fracture.
Itaconate promotes mitophagy to inhibit neuronal ferroptosis after subarachnoid hemorrhage.
Exploring the anti-inflammatory effects of Radix Curcumae essential oil in pulmonary sarcoidosis via the TLR4/MyD88/NF-κB pathway.
CpG-Based Nanovaccines Enhance Ovarian Cancer Immune Response by Gbp2-Mediated Remodeling of Tumor-Associated Macrophages.
SMARCC1 promotes M2 macrophage polarization and reduces ferroptosis in lung cancer by activating FLOT1 transcription.
S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling.
Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mousmodel of Alzheimer's disease.
Prdx5 regulates macrophage polarization by modulating the TLR4/NF-κB pathway to promote apoptosis in chronic prostatitis.
Hybrid membranes-mediated biomimetic-nanoparticle carrying miR-665 for effective tumor treatment by remodeling tumor microenvironment.
Deficiency of IL-7R attenuates abdominal aortic aneurysms in mice by inhibiting macrophage polarization towards M1 phenotype through the NF-κB pathway.
Parabacteroides distasonis promotes CXCL9 secretion of tumor-associated macrophages and enhances CD8(+)T cell activity to trigger anti-tumor immunity against anti-PD-1 treatment in non-small cell lung cancer mice.
Nicotinamide mononucleotide supplementation ameliorates testicular damage induced by ischemia-reperfusion through reshaping macrophage and neutrophil inflammatory properties.
Inhibition of Rho GEFs attenuates pulmonary fibrosis through suppressing myofibroblast activation and reprogramming profibrotic macrophages.
Tannic acid‑cerium nanoenzymes serve as broad-spectrum antioxidants to alleviate acute kidney injury by modulating macrophage polarization, mitophagy and endoplasmic reticulum stress.
Lack of ALCAT1 enhances the protective effects of aerobic exercise on kidney in HFpEF mice.
Baicalin ameliorates neuroinflammation by targeting TLR4/MD2 complex on microglia via PI3K/AKT/NF-κB signaling pathway.
Bifunctional TRPV1 Targeted Magnetothermal Switch to Attenuate Osteoarthritis Progression.
Galactomannan inhibits Trichinella spiralis invasion of intestinal epithelium cells and enhances antibody-dependent cellular cytotoxicity related killing of larvae by driving macrophage polarization.
Transglutaminase 2 inhibition ameliorates cardiac fibrosis in myocardial infarction by inducing M2 macrophage polarization in vitro and in vivo.
Mechanistic study of celastrol-mediated inhibition of proinflammatory activation of macrophages in IgA nephropathy via down-regulating ECM1.
FoxO1-Overexpressed Small Extracellular Vesicles Derived from hPDLSCs Promote Periodontal Tissue Regeneration by Reducing Mitochondrial Dysfunction to Regulate Osteogenesis and Inflammation.
Administration of Liposomal-Based Pde3b Gene Therapy Protects Mice Against Collagen-Induced Rheumatoid Arthritis via Modulating Macrophage Polarization.
HucMSC-Exo Induced N2 Polarization of Neutrophils: Implications for Angiogenesis and Tissue Restoration in Wound Healing.
Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and Polarization.
Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation.
New Insights into Roles of IL-7R Gene as a Therapeutic Target Following Intracerebral Hemorrhage.
Pretreated MSCs with IronQ Transplantation Attenuate Microglia Neuroinflammation via the cGAS-STING Signaling Pathway.
Inhibition of the MyD88 signaling pathway could upregulates Ghrelin expression to synergistically regulate hepatic Echinococcus multilocularis-infected progression.
Corilagin alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation via the Olfr2 signaling pathway in vitro and in vivo.
Quercetin ameliorates ulcerative colitis by restoring the balance of M2/M1 and repairing the intestinal barrier via downregulating cGAS‒STING pathway.
Deciphering m(6)A methylation in monocyte-mediated cardiac fibrosis and monocyte-hitchhiked erythrocyte microvesicle biohybrid therapy.
Multifunctionally disordered TiO(2) nanoneedles prevent periprosthetic infection and enhance osteointegration by killing bacteria and modulating the osteoimmune microenvironment.
Methyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis.
Genetically engineered electrospinning contributes to spinal cord injury repair by regulating the immune microenvironment.
Propionate-producing engineered probiotics ameliorated murine ulcerative colitis by restoring anti-inflammatory macrophage via the GPR43/HDAC1/IL-10 axis.
Spatiotemporal evolutionary process of osteosarcoma immune microenvironment remodeling and C1QBP-driven drug resistance deciphered through single-cell multi-dimensional analysis.
Reprogramming exosomes for immunity-remodeled photodynamic therapy against non-small cell lung cancer.
Infection‑associated bile acid disturbance contributes to macrophage activation in patients with cirrhosis.
Melatonin reverses EGFR-TKI therapeutic resistance by modulating crosstalk between circadian-related gene signature and immune infiltration patterns in patients with COVID-19 and lung adenocarcinoma.
oHSV2-mGM repolarizes TAMs and cooperates with αPD1 to reprogram the immune microenvironment of residual cancer after radiofrequency ablation.
Metabolic Control During Macrophage Polarization by a Citrate-Functionalized Scaffold for Maintaining Bone Homeostasis.
Nobiletin alleviates macrophage M2 polarization by activating AMPK-mTOR-mediated autophagy in pulmonary fibrosis mice.
The expansion of MDSCs induced by exosomal PD-L1 promotes the progression of gastric cancer.
Prophylactic Effects of Betaine on Depression and Anxiety Behaviors in Mice with Dextran Sulfate Sodium-Induced Colitis.
Macrophage membrane-camouflaged biomimetic nanoparticles for rheumatoid arthritis treatment via modulating macrophage polarization.
Ocotillol-Type Pseudoginsenoside-F11 Alleviates Lipopolysaccharide-Induced Acute Kidney Injury through Regulation of Macrophage Function by Suppressing the NF-κB/NLRP3/IL-1β Signaling Pathway.
Mitigating Viral Impact on the Radiation Response of the Lung.
Developmental PFOS exposure alters lung inflammation and barrier integrity in juvenile mice.
Mesenchymal Stem Cells Regulate Microglial Polarization via Inhibition of the HMGB1/TLR4 Signaling Pathway in Diabetic Retinopathy.
Suppressed testicular macrophage M1 polarization by HDAC5 enforces insensitivity to LPS-elicited blood-testis barrier damage.
Akkermansia muciniphila ameliorates colonic injury in mice with DSS-induced acute colitis by blocking macrophage pro-inflammatory phenotype switching via the HDAC5/DAB2 axis.
Oncolytic Peptide-Nanoplatform Drives Oncoimmune Response and Reverses Adenosine-Induced Immunosuppressive Tumor Microenvironment.
MerTK(+) macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation.
Bioactivity-Oriented Separation of "Pepper Alkaloids" from Piper sintenense Hatusima with Potential Antigouty Arthritis Activity.
Ouabain Ameliorates Alzheimer's Disease-Associated Neuropathology and Cognitive Impairment in FAD(4T) Mice.
Neutrophil N1 polarization induced by cardiomyocyte-derived extracellular vesicle miR-9-5p aggravates myocardial ischemia/reperfusion injury.
Intermittent fasting attenuates cognitive dysfunction and systemic disease activity in mice with neuropsychiatric systemic lupus erythematosus.
Developmental perfluorooctane sulfonic acid exposure exacerbates house dust mite induced allergic responses in adult mice.
A Novel Trichinella spiralis Galectin Strengthens the Macrophage ADCC Killing of Larvae via Driving M1 Polarization.
A Janus Microsphere Delivery System Orchestrates Immunomodulation and Osteoinduction by Fine-tuning Release Profiles.
Mesenchymal stem cells improve depressive disorder via inhibiting the inflammatory polarization of microglia.
Implantation of biomimetic polydopamine nanocomposite scaffold promotes optic nerve regeneration through modulating inhibitory microenvironment.
Pancreatic cancer cell-derived migrasomes promote cancer progression by fostering an immunosuppressive tumor microenvironment.
Taprenepag restores maternal-fetal interface homeostasis for the treatment of neurodevelopmental disorders.
HMGB1 Modulates Macrophage Metabolism and Polarization in Ulcerative Colitis by Inhibiting Cpt1a Expression.
miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization.
NVP-BHG712 alleviates ovariectomy-induced osteoporosis by modulating osteoclastogenesis.
Hippocampal cannabinoid type 2 receptor alleviates chronic neuropathic pain-induced cognitive impairment via microglial DUSP6 pathway in rats.
Manganese-mediated potentiation of antitumor immune responses by enhancing KLRG1(+) Macrophage function.
PLGA microspheres carrying EMSCs-CM for the effective treatment of murine ulcerative colitis.
Exosome-derived circ-001422 promotes tumor-associated macrophage M2 polarization to accelerate the progression of glioma.
Primate-specific 82-kDa choline acetyltransferase attenuates progression of Alzheimer's disease-like pathology in the APP(NL-G-F) knock-in mouse model.
Ruxolitinib improves the inflammatory microenvironment, restores glutamate homeostasis, and promotes functional recovery after spinal cord injury.
Regulatory T cell-derived exosome mediated macrophages polarization for osteogenic differentiation in fracture repair.
Macrophage M2 polarization promotes pulpal inflammation resolution during orthodontic tooth movement.
Analysis of the effects of M2 macrophage-derived PDE4C on the prognosis, metastasis and immunotherapy benefit of osteosarcoma.
MG53/GMs/HA-Dex neural scaffold promotes the functional recovery of spinal cord injury by alleviating neuroinflammation.
Fam96a is essential for the host control of Toxoplasma gondii infection by fine-tuning macrophage polarization via an iron-dependent mechanism.
Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation.
Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity.
Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway.
Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis by inhibiting the Wnt/β-catenin pathway.
A multifunctional composite nanoparticle with antibacterial activities, anti-inflammatory, and angiogenesis for diabetic wound healing.
Extracellular vesicle mediated targeting delivery of growth differentiation factor-15 improves myocardial repair by reprogramming macrophages post myocardial injury.
Lentinan inhibits cell invasion via M2 polarization of tumor-associated macrophages and Wnt/β-catenin signaling in non-small cell lung cancer.
Tibial cortex transverse transport promotes ischemic diabetic foot ulcer healing via enhanced angiogenesis and inflammation modulation in a novel rat model.
Peroxiredoxin 3 has a crucial role in the macrophage polarization by regulating mitochondrial homeostasis.
Protective effect of Tao Hong Si Wu Decoction against inflammatory injury caused by intestinal flora disorders in an ischemic stroke mouse model.
SAP130 released by ferroptosis tubular epithelial cells promotes macrophage polarization via Mincle signaling in sepsis acute kidney injury.
The Anti-Atherosclerotic Effects of Buyang Huanwu Decoction through M1 and M2 Macrophage Polarization in an ApoE Knockout Mouse Model.
Wogonin alleviates sepsis-induced acute lung injury by modulating macrophage polarization through the SIRT1-FOXO1 pathways.
Collagen sponge scaffolds loaded with Trichostatin A pretreated BMSCs-derived exosomes regulate macrophage polarization to promote skin wound healing.
Dual-crosslinking gelatin-hyaluronic acid methacrylate based biomimetic PDAC desmoplastic niche enhances tumor-associated macrophages recruitment and M2-like polarization.
CircRNA CDR1as affects functional repair after spinal cord injury and regulates fibrosis through the SMAD pathway.
Relieving Macrophage Dysfunction by Inhibiting SREBP2 Activity: A Hypoxic Mesenchymal Stem Cells-Derived Exosomes Loaded Multifunctional Hydrogel for Accelerated Diabetic Wound Healing.
Functional Oxidized Hyaluronic Acid Cross-Linked Decellularized Heart Valves for Improved Immunomodulation, Anti-Calcification, and Recellularization.
Exosomes from adipose-derived stem cells regulate macrophage polarization and accelerate diabetic wound healing via the circ-Rps5/miR-124-3p axis.
Targeted Repair of Spinal Cord Injury Based on miRNA-124-3p-Loaded Mesoporous Silica Camouflaged by Stem Cell Membrane Modified with Rabies Virus Glycoprotein.
Chishao - Fuzi herbal pair restore the macrophage M1/M2 balance in acute-on-chronic liver failure.
Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression.
Potential Involvement of M1 Macrophage and VLA4/VCAM-1 Pathway in the Valvular Damage Due to Rheumatic Heart Disease.
Wogonoside alleviates microglia-mediated neuroinflammation via TLR4/MyD88/NF-κB signaling axis after spinal cord injury.
Involvement of P2X7R-mediated microglia polarization and neuroinflammation in the response to electroacupuncture on post-stroke memory impairment.
Distinct roles of TREM2 in central nervous system cancers and peripheral cancers.
A novel p55PIK signaling peptide inhibitor alleviates neuroinflammation via the STAT3/NF-kB signaling pathway in experimental stroke.
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization.
Neuroimmune modulating and energy supporting nanozyme-mimic scaffold synergistically promotes axon regeneration after spinal cord injury.
Effect of luteolin on glioblastoma's immune microenvironment and tumor growth suppression.
Ze-Qi-Tang formula inhibits MDSCs glycolysis through the down-regulation of p21/Hif1α/Glut1 signal in psoriatic-like mice.
Ru(II)-Photoactive Agents for Targeting ER Stress and Immunogenic Cell Death.
Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats.
MSCs-exosomes can promote macrophage M2 polarization via exosomal miR-21-5p through Mesenteric injection: a promising way to attenuate murine colitis.
Inhibition of TREM-1 alleviates neuroinflammation by modulating microglial polarization via SYK/p38MAPK signaling pathway after traumatic brain injury.
Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor‑associated macrophages.
MCPIP1 alleviates depressive‑like behaviors in mice by inhibiting the TLR4/TRAF6/NF‑κB pathway to suppress neuroinflammation.
Exosomes secreted by ST3GAL5(high) cancer cells promote peritoneal dissemination by establishing a premetastatic microenvironment.
Inhibition of cGAS-STING pathway by stress granules after activation of M2 macrophages by human mesenchymal stem cells against drug induced liver injury.
Bushen Antai recipe alleviates embryo absorption by enhancing immune tolerance and angiogenesis at the maternal-fetal interface via mobilizing MDSCs in abortion-prone mice.
Diosgenin alters LPS-induced macrophage polarization by activating PPARγ/NF-κB signaling pathway.
Adipose-derived stem cell exosomes promote tumor characterization and immunosuppressive microenvironment in breast cancer.
Maimendong decoction regulates M2 macrophage polarization to suppress pulmonary fibrosis via PI3K/Akt/FOXO3a signalling pathway-mediated fibroblast activation.
κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway.
Rosmarinic acid against cognitive impairment via RACK1/HIF-1α regulated microglial polarization in sepsis-surviving mice.
METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner.
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
TREM2 regulates BV2 microglia activation and influences corticosterone-induced neuroinflammation in depressive disorders.
VSIG4 ameliorates intestinal inflammation through inhibiting macrophages NLRP3 inflammasome and pyroptosis.
Liver-Derived Ketogenesis via Overexpressing HMGCS2 Promotes the Recovery of Spinal Cord Injury.
C-C Motif Chemokine 2 Regulates Macrophage Polarization and Contributes to Myocardial Infarction Healing.
Targeted transplantation of engineered mitochondrial compound promotes functional recovery after spinal cord injury by enhancing macrophage phagocytosis.
Edaravone dexborneol alleviates cerebral ischemia-reperfusion injury through NF-κB/NLRP3 signal pathway.
MKP-1 regulates the inflammatory activation of microglia against Alzheimer's disease.
Multi-Omics Profiling Identifies Microglial Annexin A2 as a Key Mediator of NF-κB Pro-inflammatory Signaling in Ischemic Reperfusion Injury.
Dual siRNA-Loaded Cell Membrane Functionalized Matrix Facilitates Bone Regeneration with Angiogenesis and Neurogenesis.
Troxerutin dampened hypothalamic neuroinflammation via microglial IL-22/IL-22R1/IRF3 activation in dihydrotestosterone-induced polycystic ovary syndrome rats.
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Multipathway Regulation for Targeted Atherosclerosis Therapy Using Anti-miR-33-Loaded DNA Origami.
Endothelial Mitochondria Transfer to Melanoma Induces M2-Type Macrophage Polarization and Promotes Tumor Growth by the Nrf2/HO-1-Mediated Pathway.
FAM76B regulates PI3K/Akt/NF-κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA.
Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis.
SLC15A3 is transcriptionally regulated by HIF1α and p65 to worsen neuroinflammation in experimental ischemic stroke.
Novel injectable adhesive hydrogel loaded with exosomes for holistic repair of hemophilic articular cartilage defect.
Microglial EPOR Contribute to Sevoflurane-induced Developmental Fine Motor Deficits Through Synaptic Pruning in Mice.
Intervention of Tanshinone IIA on the PGK1-PDHK1 Pathway to Reprogram Macrophage Phenotype After Myocardial Infarction.
Integrated-omics profiling unveils the disparities of host defense to ECM scaffolds during wound healing in aged individuals.
TBK1 is involved in M-CSF-induced macrophage polarization through mediating the IRF5/IRF4 axis.
An advanced chitosan based sponges dressing system with antioxidative, immunoregulation, angiogenesis and neurogenesis for promoting diabetic wound healing.
Biodegradable exosome-engineered hydrogels for the prevention of peritoneal adhesions via anti-oxidation and anti-inflammation.
Injectable hyaluronate-based hydrogel with a dynamic/covalent dual-crosslinked architecture for bone tissue engineering: Enhancing osteogenesis and immune regulation.
Indole-3-Carboxaldehyde Inhibits Inflammatory Response and Lipid Accumulation in Macrophages Through the miR-1271-5p/HDAC9 Pathway.
EVA1B facilitates esophageal squamous carcinoma progression and recruitment of immunosuppressive myeloid-derived suppressor cells in the tumor microenvironment.
The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.
Swimming upregulates APOL3 through regulating macrophage polarization to inhibit glycolysis and the development of melanoma.
Cardiac Urea Cycle Activation by Time-Restricted Feeding Protects Against Pressure Overload-Induced Heart Failure.
Salidroside alleviates ferroptosis in FAC-induced Age-related macular degeneration models by activating Nrf2/SLC7A11/GPX4 axis.
Long-term hypothermia amplified neuroprotection by antagonizing intracranial pressure rebound after severe traumatic brain injury in rats.
Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1(+) Macrophages for Infectious Bone Defect Regeneration.
Tet2 modulates M2 macrophage polarization via mRNA 5-methylcytosine in allergic rhinitis.
Sulforaphane potentiates the efficacy of chemoradiotherapy in glioblastoma by selectively targeting thioredoxin reductase 1.
NIR-II Imaging for Tracking the Spatiotemporal Immune Microenvironment in Atherosclerotic Plaques.
Exosomes from human bone marrow MSCs alleviate PD-1/PD-L1 inhibitor-induced myocardial injury in melanoma mice by regulating macrophage polarization and pyroptosis.
Autophagy-mediated activation of the AIM2 inflammasome enhances M1 polarization of microglia and exacerbates retinal neovascularization.
Fucoidan improving spinal cord injury recovery: Modulating microenvironment and promoting remyelination.
A2 reactive astrocyte-derived exosomes alleviate cerebral ischemia-reperfusion injury by delivering miR-628.
A gelatin methacryloyl (GelMA) treated with gallic acid and coated with specially designed nanoparticles derived from ginseng enhances the healing of wounds in diabetic rats.
A ROS-responsive and scavenging hydrogel for postoperative abdominal adhesion prevention.
Inhibition of cGAS attenuates neonatal hypoxic-ischemic encephalopathy via regulating microglia polarization and pyroptosis.
Pterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3/Nrf1-mediated microglial activation.
Neural epidermal growth factor-like 1 protein (Nell-1) alleviates periodontal tissue destruction in periodontitis by regulating the ratio of M2/M1 macrophage phenotypes.
Psoralen protects neurons and alleviates neuroinflammation by regulating microglial M1/M2 polarization via inhibition of the Fyn-PKCδ pathway.
Adipose-derived stem cell exosomes loaded with icariin attenuated M1 polarization of macrophages via inhibiting the TLR4/Myd88/NF-κB signaling pathway.
Inhibiting PRMT1 protects against CoNV by regulating macrophages through the FGF2/PI3K/Akt pathway.
CCR5 antagonist maraviroc alleviates doxorubicin-induced neuroinflammation and neurobehavioral deficiency by regulating NF-κB/NLRP3 signaling in a breast cancer mouse model.
Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia/Macrophage M1 Polarization and JAK2/STAT3 Signaling Pathway.
Integrative analysis of network pharmacology and proteomics reveal the protective effect of Xiaoqinglong Decotion on neutrophilic asthma.
H3K18 lactylation-mediated VCAM1 expression promotes gastric cancer progression and metastasis via AKT-mTOR-CXCL1 axis.
Tumor necrosis factor α-induced protein 8-like-2 controls microglia phenotype via metabolic reprogramming in BV2 microglial cells and responses to neuropathic pain.
Calorie restriction mimetic, resveratrol, attenuates hepatic ischemia and reperfusion injury through enhancing efferocytosis of macrophages via AMPK/STAT3/S1PR1 pathway.
Dehydroandrographolide facilitates M2 macrophage polarization by downregulating DUSP3 to inhibit sepsis-associated acute kidney injury.
Integration of network pharmacology and serum medicinal chemistry to investigate the pharmacological mechanisms of QiZhuYangGan Decoction in the treatment of hepatic fibrosis.
Pyxinol Fatty Acid Ester Derivatives J16 against AKI by Selectively Promoting M1 Transition to M2c Macrophages.
Electroacupuncture promotes macrophage/microglial M2 polarization and suppresses inflammatory pain through AMPK.
Bioactive fiber-reinforced hydrogel to tailor cell microenvironment for structural and functional regeneration of myotendinous junction.
Mas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice.
Chrysin Inhibits TAMs-Mediated Autophagy Activation via CDK1/ULK1 Pathway and Reverses TAMs-Mediated Growth-Promoting Effects in Non-Small Cell Lung Cancer.
Intratumor microbiome-derived butyrate promotes lung cancer metastasis.
Adhesive hydrogel releases protocatechualdehyde-Fe(3+) complex to promote three healing stages for accelerated therapy of oral ulcers.
P-Glycoprotein Exacerbates Brain Injury Following Experimental Cerebral Ischemia by Promoting Proinflammatory Microglia Activation.
Periventricular Microglia Polarization and Morphological Changes Accompany NLRP3 Inflammasome-Mediated Neuroinflammation after Hypoxic-Ischemic White Matter Damage in Premature Rats.
Identifying Macrophage-Related Genes in Ulcerative Colitis Using Weighted Coexpression Network Analysis and Machine Learning.
Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation.
α-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated Receptor γ Simultaneously.
Integrated Analysis of Non-Coding RNA and mRNA Expression Profiles in Exosomes from Lung Tissue with Sepsis-Induced Acute Lung Injury.
Spinal cannabinoid receptor 2 activation alleviates neuropathic pain by regulating microglia and suppressing P2X7 receptor.
Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.
Jianpi Yangzheng Xiaozheng decoction alleviates gastric cancer progression via suppressing exosomal PD-L1.
Human umbilical cord mesenchymal stem cell-derived exosomes promote murine skin wound healing by neutrophil and macrophage modulations revealed by single-cell RNA sequencing.
Modulation of gut microbiota alleviates cerebral ischemia/reperfusion injury in rats by inhibiting M1 polarization of microglia.
Lycium barbarum polysaccharide alleviates dextran sodium sulfate-induced inflammatory bowel disease by regulating M1/M2 macrophage polarization via the STAT1 and STAT6 pathways.
TSAb Modulates Microglia M1 Polarization via Activation of the TSHR-Mediated NF-κB Signaling Pathway.
Ferroptosis-dependent breast cancer cell-derived exosomes inhibit migration and invasion of breast cancer cells by suppressing M2 macrophage polarization.
Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction.
Aβ Induces Neuroinflammation and Microglial M1 Polarization via cGAS-STING-IFITM3 Signaling Pathway in BV-2 Cells.
BMP7 Attenuates Neuroinflammation after Spinal Cord Injury by Suppressing the Microglia Activation and Inducing Microglial Polarization Via the STAT3 Pathway.
Electroacupuncture alleviates postoperative pain through inhibiting neuroinflammation via stimulator of interferon genes/type-1 interferon pathway.
Mechanical stiffness promotes skin fibrosis through Piezo1-mediated arginine and proline metabolism.
Resveratrol alleviates DSS-induced IBD in mice by regulating the intestinal microbiota-macrophage-arginine metabolism axis.
Trichinella spiralis dipeptidyl peptidase 1 suppressed macrophage cytotoxicity by promoting M2 polarization via the STAT6/PPARγ pathway.
Yangqing Chenfei formula alleviates crystalline silica induced pulmonary inflammation and fibrosis by suppressing macrophage polarization.
Targeting upregulation of the immunosuppressive activity of MDSCs with indirubin as a novel strategy to alleviate psoriasis.
Geniposide ameliorates atherosclerosis by regulating macrophage polarization via perivascular adipocyte-derived CXCL14.
Lactobacillus casei combined with Lactobacillus reuteri alleviate pancreatic cancer by inhibiting TLR4 to promote macrophage M1 polarization and regulate gut microbial homeostasis.
Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization.
Macrophage Sult2b1 promotes pathological neovascularization in age-related macular degeneration.
Macrophage RAGE deficiency prevents myocardial fibrosis by repressing autophagy-mediated macrophage alternative activation.
Berberine ameliorates collagen-induced arthritis in mice by restoring macrophage polarization via AMPK/mTORC1 pathway switching glycolytic reprogramming.
Peroxisome proliferator-activated receptor gamma agonist pioglitazone alleviates hemorrhage-induced thalamic pain and neuroinflammation.
ASIC1a-CMPK2-mediated M1 macrophage polarization exacerbates chondrocyte senescence in osteoarthritis through IL-18.
Chromofungin, a chromogranin A-derived peptide, protects against sepsis-induced acute lung injury by inhibiting LBP/TLR4-dependent inflammatory signaling.
Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization.
Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization.
FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression.
Electroacupuncture regulates microglial polarization via inhibiting NF-κB/COX2 pathway following traumatic brain injury.
Ursolic acid promotes microglial polarization toward the M2 phenotype via PPARγ regulation of MMP2 transcription.
Activation of glucagon-like peptide-1 receptor in microglia exerts protective effects against sepsis-induced encephalopathy via attenuating endoplasmic reticulum stress-associated inflammation and apoptosis in a mouse model of sepsis.
Silk Fibroin and Sericin Differentially Potentiate the Paracrine and Regenerative Functions of Stem Cells Through Multiomics Analysis.
Baicalein ameliorates Alzheimer's disease via orchestration of CX3CR1/NF-κB pathway in a triple transgenic mouse model.
Host genetic background regulates the capacity for anti-tumor antibody-dependent phagocytosis.
Mollugin ameliorates murine allergic airway inflammation by inhibiting Th2 response and M2 macrophage activation.
Danggui-Shaoyao-San Promotes Amyloid-β Clearance through Regulating Microglia Polarization via Trem2 in BV2 Cells.
Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization.
γ-Glutamylcysteine rescues mice from TNBS-driven inflammatory bowel disease through regulating macrophages polarization.
Three-dimensional cellular visualization in mouse apical periodontitis using combined whole-mount staining and optical tissue clearing.
Lnc-17Rik promotes the immunosuppressive function of Myeloid-Derived suppressive cells in esophageal cancer.
Realizing Highly Efficient Sonodynamic Bactericidal Capability through the Phonon-Electron Coupling Effect Using Two-Dimensional Catalytic Planar Defects.
miR-449a ameliorates acute rejection after liver transplantation via targeting procollagen-lysine1,2-oxoglutarate5-dioxygenase 1 in macrophages.
Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis.
Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.
Porcine Reproductive and Respiratory Syndrome Virus Modulates the Switch of Macrophage Polarization from M1 to M2 by Upregulating MoDC-Released sCD83.
Fecal microbiota transplantation and short-chain fatty acids protected against cognitive dysfunction in a rat model of chronic cerebral hypoperfusion.
MAGL regulates synovial macrophage polarization vis inhibition of mitophagy in osteoarthritic pain.
Reversing inflammatory microenvironment by a single intra-articular injection of multi-stimulus responsive lipogel to relieve rheumatoid arthritis and promote joint repair.
Influence of the irradiated pulmonary microenvironment on macrophage and T cell dynamics.
Celastrol-loaded biomimetic nanodrug ameliorates APAP-induced liver injury through modulating macrophage polarization.
Material Stiffness in Cooperation with Macrophage Paracrine Signals Determines the Tenogenic Differentiation of Mesenchymal Stem Cells.
Endothelial progenitor cell-derived exosomes promote anti-inflammatory macrophages via SOCS3/JAK2/STAT3 axis and improve the outcome of spinal cord injury.
Repetitive Low-Level Blast Exposure via Akt/NF-κB Signaling Pathway Mediates the M1 Polarization of Mouse Alveolar Macrophage MH-S Cells.
Klotho enhances bone regenerative function of hPDLSCs via modulating immunoregulatory function and cell autophagy.
Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle.
Hybrid Cell Membrane-Functionalized Matrixes for Modulating Inflammatory Microenvironment and Improving Bone Defect Repair.
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
SGLT2 inhibitor dapagliflozin alleviates intramyocardial hemorrhage and adverse ventricular remodeling via suppressing hepcidin in myocardial ischemia-reperfusion injury.
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation.
Selenium-Doped Mesoporous Bioactive Glass Regulates Macrophage Metabolism and Polarization by Scavenging ROS and Promotes Bone Regeneration In Vivo.
Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats.
Adenosine kinase promotes post-infarction cardiac repair by epigenetically maintaining reparative macrophage phenotype.
Dehydrocorydaline alleviates sleep deprivation-induced persistent postoperative pain in adolescent mice through inhibiting microglial P2Y(12) receptor expression in the spinal cord.
Wutou decoction attenuates the synovial inflammation of collagen-induced arthritis rats via regulating macrophage M1/M2 type polarization.
Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis.
Castor1 overexpression regulates microglia M1/M2 polarization via inhibiting mTOR pathway.
Porous composite hydrogels with improved MSC survival for robust epithelial sealing around implants and M2 macrophage polarization.
Matrix metalloproteinase-21 promotes metastasis via increasing the recruitment and M2 polarization of macrophages in HCC.
T cell-mediated targeted delivery of tadalafil regulates immunosuppression and polyamine metabolism to overcome immune checkpoint blockade resistance in hepatocellular carcinoma.
A novel transgenic mouse model expressing primate-specific nuclear choline acetyltransferase: insights into potential cholinergic vulnerability.
Betulinic Acid Inhibits the Stemness of Gastric Cancer Cells by Regulating the GRP78-TGF-β1 Signaling Pathway and Macrophage Polarization.
Quercetin improves cerebral ischemia/reperfusion injury by promoting microglia/macrophages M2 polarization via regulating PI3K/Akt/NF-κB signaling pathway.
Multi-omics analysis reveals the mechanism of action of ophiopogonin D against pulmonary fibrosis.
MiR-223-3p attenuates M1 macrophage polarization via suppressing the Notch signaling pathway and NLRP3-mediated pyroptosis in experimental autoimmune uveitis.
Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization.
GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway.
Neuron-Derived Exosomes Promote the Recovery of Spinal Cord Injury by Modulating Nerve Cells in the Cellular Microenvironment of the Lesion Area.
Synergistic effects of lipopolysaccharide and rotenone on dopamine neuronal damage in rats.
The ALOX5 inhibitor Zileuton regulates tumor-associated macrophage M2 polarization by JAK/STAT and inhibits pancreatic cancer invasion and metastasis.
Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.
Arginase 1 and L-arginine coordinate fetal lung development and the initiation of labor in mice.
Exploring the mechanism of luteolin by regulating microglia polarization based on network pharmacology and in vitro experiments.
p53 inhibits the Urea cycle and represses polyamine biosynthesis in glioma cell lines.
Functional characterization of interleukin 4 and retinoic acid signaling crosstalk during alternative macrophage activation.
Spliceosomal GTPase Eftud2 regulates microglial activation and polarization.
Vagus nerve stimulation is a potential treatment for ischemic stroke.
Human placental extract regulates polarization of macrophages via IRGM/NLRP3 in allergic rhinitis.
Wei-Tong-Xin exerts anti-inflammatory effects through TLR4-mediated macrophages M1/M2 polarization and affects GLP-1 secretion.
Berberine mitigates intracerebral hemorrhage-induced neuroinflammation in a gut microbiota-dependent manner in mice.
Analysis and verification of the circRNA regulatory network RNO_CIRCpedia_ 4214/RNO-miR-667-5p/Msr1 axis as a potential ceRNA promoting macrophage M2-like polarization in spinal cord injury.
Hypoxic ASCs-derived Exosomes Attenuate Colitis by Regulating Macrophage Polarization via miR-216a-5p/HMGB1 Axis.
Regulatory Effects of Three-Dimensional Cultured Lipopolysaccharide-Pretreated Periodontal Ligament Stem Cell-Derived Secretome on Macrophages.
SGLT2i alleviates epicardial adipose tissue inflammation by modulating ketone body-glyceraldehyde-3-phosphate dehydrogenase malonylation pathway.
Macrophage Extracellular Traps Exacerbate Secondary Spinal Cord Injury by Modulating Macrophage/Microglia Polarization via LL37/P2X7R/NF-κB Signaling Pathway.
In Vitro Immunomodulatory Effects of Inonotus obliquus Extracts on Resting M0 Macrophages and LPS-Induced M1 Macrophages.
Astragali Radix-Coptis Rhizoma Herb Pair Attenuates Atherosclerosis in ApoE-/- Mice by Regulating the M1/M2 and Th1/Th2 Immune Balance and Activating the STAT6 Signaling Pathway.
Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury.
Mesenchymal Stem Cells Improve Cognitive Impairment and Reduce Aβ Deposition via Promoting AQP4 Polarity and Relieving Neuroinflammation in Rats With Chronic Hypertension-Induced Cerebral Small-Vessel Disease.
Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NF-κB/NLRP3 signaling pathway.
Evaluation of an ImmunoPET Tracer for IL-12 in a Preclinical Model of Inflammatory Immune Responses.
TRIM21 aggravates cardiac injury after myocardial infarction by promoting M1 macrophage polarization.
A multifunctional drug consisting of tetracycline conjugated with odanacatib for efficient periodontitis therapy.
Identification and validation of a 17-gene signature to improve the survival prediction of gliomas.
Identification of the novel prognostic biomarker, MLLT11, reveals its relationship with immune checkpoint markers in glioma.
Prognostic Value and Biological Function of Galectins in Malignant Glioma.
CXCR3 antagonist AMG487 ameliorates experimental autoimmune prostatitis by diminishing Th1 cell differentiation and inhibiting macrophage M1 phenotypic activation.
Inhibition of Mer exacerbates early brain injury by regulating microglia/macrophage phenotype after subarachnoid hemorrhage in mice.
Vagus nerve stimulation promotes the M1-to-M2 transition via inhibition of TLR4/NF-κB in microglial to rescue the reperfusion injury.
Protective effects of budesonide on LPS-induced podocyte injury by modulating macrophage M1/M2 polarization: Evidence from in vitro and in silico studies.
Mechanical stress protects against chondrocyte pyroptosis through lipoxin A(4) via synovial macrophage M2 subtype polarization in an osteoarthritis model.
Structural damage to the rat eye following long-term simulated weightlessness.
Maresin 1 enhances osteogenic potential of mesenchymal stem cells by modulating macrophage peroxisome proliferator-activated receptor-γ-mediated inflammation resolution.
Injectable and reactive oxygen species-scavenging gelatin hydrogel promotes neural repair in experimental traumatic brain injury.
Peimine ameliorates pulmonary fibrosis via the inhibition of M2-type macrophage polarization through the suppression of P38/Akt/STAT6 signals.
OIT3 mediates macrophage polarization and facilitates hepatocellular carcinoma progression.
Schisandra chinensis Lignans Exert Antidepressant Effects by Promoting BV2 Microglia Polarization toward the M2 Phenotype through the Activation of the Cannabinoid Receptor Type-2-Signal Transducer and Activator of Transcription 6 Pathway.
The Clostridium Metabolite P-Cresol Sulfate Relieves Inflammation of Primary Biliary Cholangitis by Regulating Kupffer Cells.
Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury.
Urea transporter B downregulates polyamines levels in melanoma B16 cells via p53 activation.
Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Endothelial Shp2 deficiency controls alternative activation of macrophage preventing radiation-induced lung injury through notch signaling.
Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages.
Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization.
Effects of ALA-PDT on the macrophages in wound healing and its related mechanisms in vivo and in vitro.
Rutin Inhibits Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation by Inducing Autophagy and Modulating PI3K/ATK Signaling.
Implantation of a nerve protector embedded with human GMSC-derived Schwann-like cells accelerates regeneration of crush-injured rat sciatic nerves.
Progranulin deficiency promotes persistent neuroinflammation and causes regional pathology in the hippocampus following traumatic brain injury.
Epithelial‑derived exosomes promote M2 macrophage polarization via Notch2/SOCS1 during mechanical ventilation.
Wharton's jelly mesenchymal stem cell-derived small extracellular vesicles as natural nanoparticles to attenuate cartilage injury via microRNA regulation.
Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response.
Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment.
Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer.
C1q inhibits differentiation of oligodendrocyte progenitor cells via Wnt/β-catenin signaling activation in a cuprizone-induced mouse model of multiple sclerosis.
One-Step Synthesis of Multifunctional Chitosan Hydrogel for Full-Thickness Wound Closure and Healing.
miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression.
Myoglobin promotes macrophage polarization to M1 type and pyroptosis via the RIG-I/Caspase1/GSDMD signaling pathway in CS-AKI.
Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway.
Caffeine treatment started before injury reduces hypoxic-ischemic white-matter damage in neonatal rats by regulating phenotypic microglia polarization.
Exosomes derived from bone marrow mesenchymal stem cells inhibit neuroinflammation after traumatic brain injury.
GABA regulates IL-1β production in macrophages.
An SPM-Enriched Marine Oil Supplement Shifted Microglia Polarization toward M2, Ameliorating Retinal Degeneration in rd10 Mice.
Overexpressed DDX3x promotes abdominal aortic aneurysm formation and activates AKT in ApoE knockout mice.
Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes.
Notoginsenoside R1-loaded mesoporous silica nanoparticles targeting the site of injury through inflammatory cells improves heart repair after myocardial infarction.
A cell-free difunctional demineralized bone matrix scaffold enhances the recruitment and osteogenesis of mesenchymal stem cells by promoting inflammation resolution.
MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization.
Urea as a By-Product of Ammonia Metabolism Can Be a Potential Serum Biomarker of Hepatocellular Carcinoma.
lncRNA Gm16410 Mediates PM(2).(5)-Induced Macrophage Activation via PI3K/AKT Pathway.
MCC950 Ameliorates Acute Liver Injury Through Modulating Macrophage Polarization and Myeloid-Derived Suppressor Cells Function.
Inhibition of Sphingosine-1-Phosphate Receptor 2 Prevents Thoracic Aortic Dissection and Rupture.
PAK1 Silencing Attenuated Proinflammatory Macrophage Activation and Foam Cell Formation by Increasing PPARγ Expression.
Sodium Lactate Accelerates M2 Macrophage Polarization and Improves Cardiac Function after Myocardial Infarction in Mice.
The Effect of miR-520b on Macrophage Polarization and T Cell Immunity by Targeting PTEN in Breast Cancer.
Metformin Alleviates Neuroinflammation Following Intracerebral Hemorrhage in Mice by Regulating Microglia/Macrophage Phenotype in a Gut Microbiota-Dependent Manner.
A Novel Hydrogen Sulfide Donor Reduces Pilocarpine-Induced Status Epilepticus and Regulates Microglial Inflammatory Profile.
The Impact of β-1,4-Galactosyltransferase V on Microglial Function.
Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice.
β2-Adrenergic Receptor Enhances the Alternatively Activated Macrophages and Promotes Biliary Injuries Caused by Helminth Infection.
Loss of Diacylglycerol Kinase α Enhances Macrophage Responsiveness.
PD-L1 Improves Motor Function and Alleviates Neuropathic Pain in Male Mice After Spinal Cord Injury by Inhibiting MAPK Pathway.
Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation.
Suppressing Sart1 to modulate macrophage polarization by siRNA-loaded liposomes: a promising therapeutic strategy for pulmonary fibrosis.
Pseudomonas aeruginosa PcrV Enhances the Nitric Oxide-Mediated Tumoricidal Activity of Tumor-Associated Macrophages via a TLR4/PI3K/AKT/mTOR-Glycolysis-Nitric Oxide Circuit.
Colon-Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora.
Abdominal paracentesis drainage attenuates intestinal mucosal barrier damage through macrophage polarization in severe acute pancreatitis.
Matrix stiffness regulates bone repair by modulating 12-lipoxygenase-mediated early inflammation.
Intracellular Sphingosine-1-Phosphate Receptor 3 Contributes to Lung Tumor Cell Proliferation.
Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder.
Ameliorative effects of miR-423-5p against polarization of microglial cells of the M1 phenotype by targeting a NLRP3 inflammasome signaling pathway.
Pharmacological Activation of RXR-α Promotes Hematoma Absorption via a PPAR-γ-dependent Pathway After Intracerebral Hemorrhage.
Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke.
The Protective Role of Yin-Yang 1 in Cardiac Injury and Remodeling After Myocardial Infarction.
Myeloid TBK1 Deficiency Induces Motor Deficits and Axon Degeneration Through Inflammatory Cell Infiltration.
CSF1/CSF1R-mediated Crosstalk Between Choroidal Vascular Endothelial Cells and Macrophages Promotes Choroidal Neovascularization.
Loganin alleviates sepsis-induced acute lung injury by regulating macrophage polarization and inhibiting NLRP3 inflammasome activation.
A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.
Caloric restriction ameliorates high-fat diet induced cognitive deficits through attenuating neuroinflammation via the TREM2-PI3K/AKT signaling pathway.
Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-κB p65 mediated modulation of microglia polarization.
Amniotic fluid-derived multipotent stromal cells drive diabetic wound healing through modulation of macrophages.
Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer.
Preventive and Therapeutic Spermidine Treatment Attenuates Acute Colitis in Mice.
Myeloid NEMO deficiency promotes tumor immunosuppression partly via MCP1-CCR2 axis.
Schizandrin A ameliorates cognitive functions via modulating microglial polarisation in Alzheimer's disease mice.
Saponins from Panax japonicus attenuate cognitive impairment in ageing rats through regulating microglial polarisation and autophagy.
PLXNA2 knockdown promotes M2 microglia polarization through mTOR/STAT3 signaling to improve functional recovery in rats after cerebral ischemia/reperfusion injury.
Curcumin protects human umbilical vein endothelial cells against high oxidized low density lipoprotein-induced lipotoxicity and modulates autophagy.
The glycolysis inhibitor 2-deoxyglucose ameliorates adjuvant-induced arthritis by regulating macrophage polarization in an AMPK-dependent manner.
Inhibition of Dectin-1 Ameliorates Neuroinflammation by Regulating Microglia/Macrophage Phenotype After Intracerebral Hemorrhage in Mice.
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
Probiotic Bacillus cereus Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice through Improvement of the Intestinal Barrier Function, Anti-Inflammation, and Gut Microbiota Modulation.
FNDC5 induces M2 macrophage polarization and promotes hepatocellular carcinoma cell growth by affecting the PPARγ/NF-κB/NLRP3 pathway.
LncRNA LINC01088 inhibits the function of trophoblast cells, activates the MAPK-signaling pathway and associates with recurrent pregnancy loss.
Inhibition of P2X4R attenuates white matter injury in mice after intracerebral hemorrhage by regulating microglial phenotypes.
Simvastatin Enhances Muscle Regeneration Through Autophagic Defect-Mediated Inflammation and mTOR Activation in G93ASOD1 Mice.
Distinct phenotypic expression levels of macrophages in neonatal lungs.
M2 Macrophage-Derived Exosomal miR-590-3p Attenuates DSS-Induced Mucosal Damage and Promotes Epithelial Repair via the LATS1/YAP/ β-Catenin Signalling Axis.
Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer's Disease.
Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson's Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo.
Hypothermia-Induced Ubiquitination of Voltage-Dependent Anion Channel 3 Protects BV2 Microglia Cells From Cytotoxicity Following Oxygen-Glucose Deprivation/Recovery.
Csf2 Attenuated Sepsis-Induced Acute Kidney Injury by Promoting Alternative Macrophage Transition.
AhR activation attenuates calcium oxalate nephrocalcinosis by diminishing M1 macrophage polarization and promoting M2 macrophage polarization.
Sulforaphane elicts dual therapeutic effects on Renal Inflammatory Injury and crystal deposition in Calcium Oxalate Nephrocalcinosis.
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
Fucoidan inhibits tooth movement by promoting restorative macrophage polarization through the STAT3 pathway.
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
MG53 Protects hUC-MSCs against Inflammatory Damage and Synergistically Enhances Their Efficacy in Neuroinflammation Injured Brain through Inhibiting NLRP3/Caspase-1/IL-1β Axis.
Anti-arthritis effect of berberine associated with regulating energy metabolism of macrophages through AMPK/ HIF-1α pathway.
A free-standing multilayer film as a novel delivery carrier of platelet lysates for potential wound-dressing applications.
Ketogenic Diet Elicits Antitumor Properties through Inducing Oxidative Stress, Inhibiting MMP-9 Expression, and Rebalancing M1/M2 Tumor-Associated Macrophage Phenotype in a Mouse Model of Colon Cancer.
Blocking P2X7-Mediated Macrophage Polarization Overcomes Treatment Resistance in Lung Cancer.
Keratinocyte-Macrophage Crosstalk by the Nrf2/Ccl2/EGF Signaling Axis Orchestrates Tissue Repair.
The effect of combining Endostar with radiotherapy on blood vessels, tumor-associated macrophages, and T cells in brain metastases of Lewis lung cancer.
TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.
Functional changes of the liver in the absence of growth hormone (GH) action - Proteomic and metabolomic insights from a GH receptor deficient pig model.
Relationship of tumour-associated macrophages with poor prognosis in Wilms' tumour.
Beneficial Effects of Theta-Burst Transcranial Magnetic Stimulation on Stroke Injury via Improving Neuronal Microenvironment and Mitochondrial Integrity.
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
An extracorporeal bioartificial liver embedded with 3D-layered human liver progenitor-like cells relieves acute liver failure in pigs.
SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α.
Aminooxyacetic acid attenuates post-infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice.
Analysis of Cyclooxygenase 2, Programmed Cell Death Ligand 1, and Arginase 1 Expression in Human Pituitary Adenoma.
Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization.
Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway.
An injectable recombinant human milk fat globule-epidermal growth factor 8-loaded copolymer system for spinal cord injury reduces inflammation through NF-κB and neuronal cell death.
Alternatively activated macrophages are associated with the α2AP production that occurs with the development of dermal fibrosis : The role of alternatively activated macrophages on the development of fibrosis.
Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation.
Suppressed androgen receptor expression promotes M2 macrophage reprogramming through the STAT3/SOCS3 pathway.
Myeloid-Derived Suppressor Cells and γδT17 Cells Contribute to the Development of Gastric MALT Lymphoma in H. felis-Infected Mice.
Role of Tim-3 in Decidual Macrophage Functional Polarization During Abnormal Pregnancy With Toxoplasma gondii Infection.
Fusobacterium nucleatum Aggravates the Progression of Colitis by Regulating M1 Macrophage Polarization via AKT2 Pathway.
Pancreatic cancer-educated macrophages protect cancer cells from complement-dependent cytotoxicity by up-regulation of CD59.
Macrophage polarization in periodontal ligament stem cells enhanced periodontal regeneration.
Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion.
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy.
Berberine attenuates arthritis in adjuvant-induced arthritic rats associated with regulating polarization of macrophages through AMPK/NF-кB pathway.
Toxoplasma ROP16(I/III) ameliorated inflammatory bowel diseases via inducing M2 phenotype of macrophages.
Tandem Mass Tag Proteomic Analysis of in Vitro and in Vivo Models of Cutaneous Leishmaniasis Reveals Parasite-Specific and Nonspecific Modulation of Proteins in the Host.
Metformin enhances gefitinib efficacy by interfering with interactions between tumor-associated macrophages and head and neck squamous cell carcinoma cells.
Interleukin-1 receptor associated kinase (IRAK)-M -mediated type 2 microglia polarization ameliorates the severity of experimental autoimmune encephalomyelitis (EAE).
Comparative Proteomic Analysis of Murine Cutaneous Lesions Induced by Leishmania amazonensis or Leishmania major.
Targeted Delivery of miRNA 155 to Tumor Associated Macrophages for Tumor Immunotherapy.
Aryl Hydrocarbon Receptor Regulates Apoptosis and Inflammation in a Murine Model of Experimental Autoimmune Uveitis.
Effective Amelioration of Liver Fibrosis Through Lentiviral Vector Carrying Toxoplasma gondii gra15(II) in Murine Model.
The Role of Alpha-Lipoic Acid in the Pathomechanism of Acute Ischemic Stroke.
Rapamycin and FTY720 Alleviate Atherosclerosis by Cross Talk of Macrophage Polarization and Autophagy.
Targeting MAPK Pathways by Naringenin Modulates Microglia M1/M2 Polarization in Lipopolysaccharide-Stimulated Cultures.
Clemastine Alleviates Depressive-Like Behavior Through Reversing the Imbalance of Microglia-Related Pro-inflammatory State in Mouse Hippocampus.
S100A8/A9 induces microglia activation and promotes the apoptosis of oligodendrocyte precursor cells by activating the NF-κB signaling pathway.
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
ER-localized protein-Herpud1 is a new mediator of IL-4-induced macrophage polarization and migration.
Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells.
Interleukin-33 Protects Ischemic Brain Injury by Regulating Specific Microglial Activities.
Treadmill Exercise Exerts Neuroprotection and Regulates Microglial Polarization and Oxidative Stress in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer's Disease.
GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages.
Matrine promotes NT3 expression in CNS cells in experimental autoimmune encephalomyelitis.
Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model.
Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion.
Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis.
A(H1N1) vaccination recruits T lymphocytes to the choroid plexus for the promotion of hippocampal neurogenesis and working memory in pregnant mice.
Neonatal BCG vaccination of mice improves neurogenesis and behavior in early life.
Effects of IL-4 on pulmonary fibrosis and the accumulation and phenotype of macrophage subpopulations following thoracic irradiation.
M2 Polarization of Monocytes-Macrophages Is a Hallmark of Indian Post Kala-Azar Dermal Leishmaniasis.
Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors.
Ethanol supports macrophage recruitment and reinforces invasion and migration of Lewis lung carcinoma.
Hu J, Xu Y, Zhou D, Chen K, Jiang J, Lin M, Chen W, Wu J, Jiang H, Zhu M, Zhang B, Xu K, Wei P
Biomaterials research 2026;30:0309
Biomaterials research 2026;30:0309
After Traumatic Brain Injury, EPHA4 Enhances Endoplasmic Reticulum Stress to Promote M1 Microglial Polarization Through the MAPK Signaling Pathway.
Tan Y, Xia J, Liu M, Deng S, Wu H, Qian C
Mediators of inflammation 2026;2026:5595023
Mediators of inflammation 2026;2026:5595023
The mechanism of Vicenin-2 in ameliorating skin photoaging: involvement of m6A-modified macrophage polarization.
Zhou Y, Shuai W, Peng X, Li R, Chen M, Tan B, Mu Y, Duan X
Frontiers in pharmacology 2026;17:1778993
Frontiers in pharmacology 2026;17:1778993
RP-182 alleviated obstruction-induced renal fibrosis by reprogramming CD206(+) macrophages.
Cao H, Chen X, Jin R, Yang Y, Tao Y, Li P, Wu Y, Chen G, Zhao J, Wen J, Zhao Y, Wei L, Wei Z, Lu D, Chen Y, Liu D, Zhou H, Cheng J
Frontiers in pharmacology 2026;17:1739457
Frontiers in pharmacology 2026;17:1739457
GCDCA promotes hepatocellular carcinoma progression through S1PR2/PI3K/AKT-mediated polarization of M2-type macrophages.
Xue M, Yu W, Zhang K, Chen Y, Zhang L, Zhang H, Lu S, Tao M, Yan H, Wei L, Lv G, Gao L, Zhang L
Frontiers in immunology 2026;17:1640450
Frontiers in immunology 2026;17:1640450
CCL5 promotes angiotensin II-induced cardiac remodeling through regulation of platelet-driven M2 macrophage polarization.
Lv S, Zhou M, Li T, Zeng Z, Yan Z, Hou Y, Yang L, Zhang F, Zhao W, Zhou Y, Yang M
Theranostics 2026;16(2):689-711
Theranostics 2026;16(2):689-711
A near-infrared regulated programmable multi-mode periosteum scaffold for sequential healing of infected bone defects.
Yin Y, Cai Y, Dang P, Zeng W, Wang L, Yan X, Luo Z, Liu W, Zhu Y, Chen L, Zhang C
Bioactive materials 2026 Sep;63:56-72
Bioactive materials 2026 Sep;63:56-72
PRSS23 functions downstream of ZEB1 to promote esophageal squamous cell carcinoma progression by driving M2 polarization of tumor associated macrophages.
Chen W, Chen C, Hu Z, Li F, Peng Y, Zhang M
Molecular and cellular biochemistry 2026 May;481(5):2175-2192
Molecular and cellular biochemistry 2026 May;481(5):2175-2192
Study on the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula by inhibiting M2 macrophage polarization and regulating TGF - β/SMAD signaling pathway.
Hong L, Sun Y, Hou H, Zhang J, Shi W, Yang Y, Fan X, Zhu J
Journal of ethnopharmacology 2026 May 23;363:121465
Journal of ethnopharmacology 2026 May 23;363:121465
Yinhuo Decoction attenuates depression-like behaviors and promotes M2 microglia polarization by regulating PI3K/Akt/NF-κB signaling pathway in a murine model of menopausal depression.
Zhang Y, Lei X, Xue A, Zhao D, Ai H, Zhou Y, Wang W, Zhang N, Geng F, Xu H
Journal of ethnopharmacology 2026 May 23;363:121365
Journal of ethnopharmacology 2026 May 23;363:121365
M2 macrophage-mediated tigecycline nanoparticles for combating CRKP pneumonia via antibacterial and immunomodulatory therapy.
Cheng W, Wu L, Liao Y, Zhang T, Han X, Tai Z, Zhu Q, Chen Z, Tian J, Ding N, Wang Z
Journal of controlled release : official journal of the Controlled Release Society 2026 May 10;393:114810
Journal of controlled release : official journal of the Controlled Release Society 2026 May 10;393:114810
Taohong Siwu decoction and its components regulate the M1/M2 polarization of macrophages to alleviate inflammatory injury in sepsis via the RAGE.
Han X, Pang M, Hu C, Li Y, Xu T, Xu H, Ye H, Xie L, Shen A, Liu B, Zhang G, Zhou Y
Journal of ethnopharmacology 2026 May 10;362:121366
Journal of ethnopharmacology 2026 May 10;362:121366
Macrophage AMPK activated by oxidative stress drives profibrotic crosstalk with tubular cells to accelerate renal fibrosis after ischemic and reperfusion injury.
Tao Y, Zhang M, Chen L, Jia H, Yang Y, Wu Y, Li P, Wen Z, Zhang X, Chen X, Chen X, Li X, Zhou H
Redox biology 2026 Mar;90:104002
Redox biology 2026 Mar;90:104002
Engineering multifunctional microspheres for sequential regulation of osteoimmune microenvironment and bone remodeling balance to promote regeneration of osteoporotic bone defects.
Luo Z, Ma J, Yang Y, Zhang H, Du Y, Dai J, Wang Y, Zhang W, Ma X, Lai Y
Journal of orthopaedic translation 2026 Mar;57:101054
Journal of orthopaedic translation 2026 Mar;57:101054
Dynamic ROS-responsive hyperbranched polymer-based neuroprotective drug delivery system for pathogenesis-adaptive sequential therapy of cerebral ischemic stroke.
Ma X, Zhang X, Wang Y, Xu Y, Liu L, Li W, Ren X, He Z
Biomaterials 2026 Mar;326:123683
Biomaterials 2026 Mar;326:123683
Modulation of immune cell differentiation by Prunella vulgaris L. essential oil in pulmonary sarcoidosis treatment.
Mao Z, Yang X, Liu Y, Huan Y, Gao Y, Zhang J, Lin X, Tian S, Song Y, Miao M
Fitoterapia 2026 Mar;189:107049
Fitoterapia 2026 Mar;189:107049
Early Radial Extracorporeal Shockwave Stimulation on Proximal Tibial Circular Osteotomy Site Enhanced Heterotopic Skin Wound Healing via Small Extracellular Vesicles.
Xie X, Bi S, Su B, Zhou R, Li X, Yan Z, Zhou X, Wang F, Yu T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(16):e17257
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(16):e17257
Red Blood Cell-Derived Exosomes Deliver Complement C5 to Exacerbate Neuroinflammation and Neuronal Injury after Intracerebral Hemorrhage.
Chen Q, Min J, Lu X, Gao Z, Xiong Y
Inflammation 2026 Mar 5;49(1)
Inflammation 2026 Mar 5;49(1)
Glycogen Hydrogel Loaded with Schistosoma japonicas Peptide SJMHE1 Improves Skin Wound Healing.
Yang Y, Wang S, Jiang Y, Huo L, Zhu W, Zhang X, Zhang Y, Wang X
Biomolecules 2026 Mar 5;16(3)
Biomolecules 2026 Mar 5;16(3)
ZXDB Drives Macrophage Inflammatory Programming in Sepsis-Induced Acute Kidney Injury by Recruiting EIF4A3 to Enhance ACACA Translation.
Wu H, Gang W, Wang L, Sun J, Li S, Guo Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71657
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71657
Vericiguat Attenuates Post-Myocardial Infarction Inflammation Associated With Macrophage Polarization and Regulation of the Survivin/Caspase-6 Pathway.
Zhao Y, Li H, Wu Z, Yin Y, Wang H, Zhang L, Zhang Y, Jiang B, Jiang T, Li H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71635
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71635
Cordycepin alleviates ischaemic brain injury by suppressing microglia-induced neuroinflammation via regulating the Notch1 signalling pathway.
Li X, Zhan GF, Zhang X, Zhao YL, Mao M, Xia Q
British journal of pharmacology 2026 Mar 30;
British journal of pharmacology 2026 Mar 30;
Cancer cell-derived sialylated IgG interacting with Siglec-7/9/10 is a potential immunotherapeutic target in pancreatic cancer.
Zhang S, Cui M, Huang X, Feng X, Xiao R, Liu Q, Bai J, Han X, Liu X, Xu W, Huang J, Liao Q, Zhao Y, Qiu X
Cell reports. Medicine 2026 Mar 17;7(3):102660
Cell reports. Medicine 2026 Mar 17;7(3):102660
Tanshinone IIA-pretreated mesenchymal stem cells alleviate neuroinflammation in 3×Tg-AD mice via the TREM2/PI3K/Akt pathway.
Wu J, Ge Y, Zhang L, Huang J, Huang N, Luo Y
Stem cell research & therapy 2026 Mar 17;17(1)
Stem cell research & therapy 2026 Mar 17;17(1)
ROS-Responsive Prodrug Containing Dihydroartemisinin and Cinnamaldehyde for the Potential Treatment of Nonalcoholic Steatohepatitis.
Hao R, Sun Y, Wang C, Wang Y, Li L, Sun H, Chen L
ACS applied materials & interfaces 2026 Mar 11;18(9):13384-13397
ACS applied materials & interfaces 2026 Mar 11;18(9):13384-13397
ROS-responsive hydrogels functionalized with Cu/Zn MOF targeting oxidative stress mitigation and inflammation modulation to promote spinal cord injury repair.
Ma Y, Liu Y, Xie T, Zhao Y, Liu S, Ju C, Li H, Wang Y, Luo R, Wang X, Huang D, Yan L, Zhu L, Hu H
Materials today. Bio 2026 Jun;38:103106
Materials today. Bio 2026 Jun;38:103106
Exosomal lncRNA OTUD6B-AS1 as a pathogenic nanocarrier promotes inflammatory macrophage polarization in endometritis via a targetable ceRNA circuit.
Yang J, Chen Y, Wang K, Mi L, Chen Y, Li X, Yin G, Jiang K
Materials today. Bio 2026 Jun;38:103027
Materials today. Bio 2026 Jun;38:103027
Chaotrope-guided protein microneedles with high drug-loading capacity, ultrafast dissolution, and high mechanical strength.
Zeng K, Xie Y, Zhang Y, Dong Y, Cheng H, Xiong D, Li Y, Lou F, Hu Z, Shi Y, Wang Z, Ye L
Acta biomaterialia 2026 Jun;216:156-171
Acta biomaterialia 2026 Jun;216:156-171
Integrated whole transcriptome sequencing, network pharmacology and in vivo validation reveal that Compound Wufengcao Liquid promotes pressure injury healing via PPARγ-mediated macrophage polarization.
Deng R, Qian J, Bu Q, Cao T, Liu Y, Gao M, Huang Z
Fitoterapia 2026 Jun;191:107260
Fitoterapia 2026 Jun;191:107260
TREM2 activation suppresses central sensitisation by promoting autophagy in a chronic migraine model with recurrent nitroglycerin stimulation in mice.
Hu S, Liu X, Zhang L, Zhong S, Liang Z, Zeng W, Yi L, Zeng Z, Chen B, Wang R
British journal of pharmacology 2026 Jun;183(11):2803-2819
British journal of pharmacology 2026 Jun;183(11):2803-2819
Collagen-oxidized hyaluronic acid injectable self-healing hydrogel enabling sequential platelet-rich plasma release for microenvironment modulation in diabetic wound repair.
Tan B, Chen L, Feng T, Swamiappan S, Zhang X, Lai Z, Yang Y, Chen S, Peng X, Zhou H
Biomaterials advances 2026 Jun;183:214777
Biomaterials advances 2026 Jun;183:214777
Engineered mesenchymal stem cell-derived extracellular vesicles attenuate acute glaucoma-induced neuroinflammation by reprogramming microglial polarization.
Luo A, Yu H, Duan T, Li M, Zheng R, He S, Huang J
International immunopharmacology 2026 Jun 15;179:116658
International immunopharmacology 2026 Jun 15;179:116658
Kaiyujiangzhuo formula alleviates glycolipid metabolic disorders by improving arginine metabolism and inhibiting the ERK-mediated PPARγ-Ser273 phosphorylation.
Shi Y, Zhang Z, Lin H, Wang S, Wang D, Wu H, Qi H, Wang Y, Liu Q, Zhang Y, Xiong H, Ren J, Li X, Wang Z
Journal of ethnopharmacology 2026 Jun 12;364:121508
Journal of ethnopharmacology 2026 Jun 12;364:121508
Phyllanthin Targets GBP5 to Suppress Macrophage M1 Polarization and Alleviate DSS-Induced Colitis in a Murine Model.
Yin L, Geng Z, Zhang K, Zhang Y, Niu M, Huang J, Li Q, Li J, Hu H, Hu J, Li J
Journal of ethnopharmacology 2026 Jun 12;364:121499
Journal of ethnopharmacology 2026 Jun 12;364:121499
Unraveling the therapeutic mechanisms of Polygonum cuspidatum in pulmonary fibrosis: Modulation of M2 macrophage polarization and glycolysis pathways.
Gao Y, Ng CYJ, Ni K, Hu Q, Shi X, Si T, Zhang X, Yang J, Yang J, Xu T
Journal of ethnopharmacology 2026 Jun 12;364:121461
Journal of ethnopharmacology 2026 Jun 12;364:121461
Cu(2+)-chelated epigallocatechin gallate nanoparticle-functionalized hydrogel promotes osteogenesis by inhibiting ferroptosis.
Li C, Li J, Chen S, Xia J, Song J, Hu T, Cui Z, Gu G, Chen F, Mei Z, Ding Y, Xie D, Wu X, Shao J, Du Y, Zheng L, Hu C, Xi Y
Journal of controlled release : official journal of the Controlled Release Society 2026 Jun 10;394:114840
Journal of controlled release : official journal of the Controlled Release Society 2026 Jun 10;394:114840
Inhibition of endothelial ALOX12 mitigates cerebral ischemia-reperfusion injury by suppressing 12-HETE.
Wang T, Zhang J, Lu G, Han D, Mi T, Ma X, Wang L, He Z, Niu J
Free radical biology & medicine 2026 Jul;250:134-152
Free radical biology & medicine 2026 Jul;250:134-152
Scutebarbatine A inhibits M2 macrophage polarization via blocking PI3K/AKT signaling to impair cell stemness, metastasis, and angiogenesis in non-small cell lung cancer.
Zhang Y, He C, Yang X, Gu M
Gene 2026 Jul 5;997:150118
Gene 2026 Jul 5;997:150118
Methyl 3-chloroasterric acid exerted anti-neuroinflammatory and antidepressant effects through the downregulation of P2Y1R.
Zhang Y, Sun M, Zhang Z, Jia Y, Xiao H, Xu X, Pan X, Li Z
International immunopharmacology 2026 Jul 15;181:116689
International immunopharmacology 2026 Jul 15;181:116689
The role of the IL-33/ST2/MAPK signalling pathway in macrophage polarisation and endometrial fibrosis.
Li G, Xu F, Luo S, Jin Y, Yuan L, Yang X, Xuan T, Liu D
International immunopharmacology 2026 Jul 1;180:116743
International immunopharmacology 2026 Jul 1;180:116743
Diallyl Trisulfide Suppresses Tumor-Associated Macrophage M2-Like Polarization and Recruitment and Improves the Tumor Microenvironment Through Blocking CCL5/STAT3 Signaling Pathway Against Lung Cancer.
Xie C, Yin J, Zhu J
Phytotherapy research : PTR 2026 Jan;40(1):318-333
Phytotherapy research : PTR 2026 Jan;40(1):318-333
Targeting aldose reductase in pulmonary fibrosis: Blocking de novo fatty acid synthesis halts pro-fibrotic M2 polarization.
Li J, Zhang Q, Zhao P, Mei X, Shi Y, Shao W, Yu X
International journal of biological macromolecules 2026 Jan;337(Pt 2):149590
International journal of biological macromolecules 2026 Jan;337(Pt 2):149590
Adipose-derived stem cells (ADSCs)-derived DKK1 promotes cutaneous wound healing by inducing M2 macrophage polarization via PI3K/AKT and JNK activation.
Liu D, Liu N, Liu X, Liu Y, Zhang H, Zhou Z, Zheng J, Tian Y
Biochimica et biophysica acta. Molecular cell research 2026 Jan;1873(1):120077
Biochimica et biophysica acta. Molecular cell research 2026 Jan;1873(1):120077
Impaired nitrogenous waste clearance promotes hepatocellular carcinoma.
Han X, Shen J, Yan J, Tacke R, Dai W, Mao Q, Queen Daguplo H, Liu S, Islam A, Liu T, Koch MC, Lin RZ, Li H, Anthony T, Xie P, Zhang L, Gao S, Simon MC, Chen X, Yang J, Su X, Zong WX
Science advances 2026 Jan 9;12(2):eaec0766
Science advances 2026 Jan 9;12(2):eaec0766
Integrating single cell- and spatial- resolved transcriptomics unravels the inter-tumor heterogeneity and immunosuppressive landscape in HBV- and Clonorchis sinensis-associated hepatocellular carcinoma.
Chen J, Lu W, Lou Y, Liu J, Liao X, Bai Y, Cheng G, Zhu G, Feng J, Liu J, Liu Z, Jia L, Zhou J, Peng T, Lu GD, Wang J
Molecular cancer 2026 Jan 5;25(1):3
Molecular cancer 2026 Jan 5;25(1):3
Ptbp2 Alleviates Neuroinflammation and Blood-brain Barrier Disruption via Modulating Microglial Polarization in Ischemic Stroke.
Xu W, Li L, Zhou M, Zhang C, Zhang X
Molecular neurobiology 2026 Jan 30;63(1):408
Molecular neurobiology 2026 Jan 30;63(1):408
Anti-tumor effect of flavonoids isolated from Bidens Pilosa L. by regulating the activity of myeloid-derived suppressor cells within the tumor microenvironment in mice.
Tao Y, Du M, Zhu M, Sun W, Zeng G, Xiong J, Li J, Yang Z, Fan B, Zhang R, Zeng G
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120635
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120635
Rewiring brain structural and functional disconnection with acupuncture in rat model of vascular cognitive impairment and dementia.
Wang L, Zhao JP, Cao Y, Ma SM, Yang JW, Su XT, Huang J, Wang QY, Liu CZ
Biological research 2026 Jan 19;59(1):10
Biological research 2026 Jan 19;59(1):10
Caveolin-2 Knockdown Alleviated Sepsis-induced Acute Lung Injury Via Promoting Macrophage M2 Polarization and Inhibiting Apoptosis by Hippo Signaling Pathway.
Xue X, Gao F, Chen J, Wang M, Wu X, Liao H, Sun Z, Nie S
Inflammation 2026 Jan 19;49(1):66
Inflammation 2026 Jan 19;49(1):66
E3 ubiquitin ligase trim36 targets ddx3x for degradation to reprogram macrophage polarization and ameliorate tubal factor infertility in rats.
Shao L, Wang N, Yan Y, Zhao C, Tan Y, Wu Q, Tan Q, Huang Y, Liu L
Cell biology and toxicology 2026 Jan 19;42(1):23
Cell biology and toxicology 2026 Jan 19;42(1):23
Functional remodeling of iNKT cells by sulfatide-reactive type II NKT cells reprograms alveolar macrophages to alleviate lung ischemia-reperfusion injury.
Li Q, Yin J, Lin Q, Xu Y, He J, Shi X, Huang S, Wang Y, Huang Y, Ding X, Yu H, Nie H
Communications biology 2026 Jan 17;9(1)
Communications biology 2026 Jan 17;9(1)
Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation.
Wang Z, Zhang Z, Xin R, Ma M, Sun Z, Li Z, Zhang C, Liu L, Wu Z, Zhang Y, Chen Y
Inflammation 2026 Jan 16;49(1):49
Inflammation 2026 Jan 16;49(1):49
Acupuncture as a modulator of microglial polarization and pyroptosis in depression: evidence from a chronic unpredictable mild stress rat model.
Wu X, You Z, Zhang T, Zeng J, Li M, Yan S, Li J, Li P, Shen J, Liu S, Aslam MS, Li J, Ning L, Fang H, Li Y, Yao D, Hao C, Meng X
Metabolic brain disease 2026 Jan 16;41(1):20
Metabolic brain disease 2026 Jan 16;41(1):20
Mechanistic insights into the effects of Norisoboldine on intestinal immunity and neuroinflammation in a mouse model of slow transit constipation with depression.
Wu B, Wu J, Bai X, Zhou Q, Wang X
Journal of ethnopharmacology 2026 Jan 10;354:120479
Journal of ethnopharmacology 2026 Jan 10;354:120479
CXCL9- preconditioned BMSCs attenuate rat post-traumatic osteoarthritis by modulating synovial macrophage polarization via the TLR2/TGF-β2 signaling pathway.
Li H, Wang T, Li F, Xie Z, Luo H, Zhang K, Li Y, Dong W, Wu J, Zhang J, Zhang F, Peng W
International immunopharmacology 2026 Jan 1;168(Pt 2):115936
International immunopharmacology 2026 Jan 1;168(Pt 2):115936
Dissecting macrophage heterogeneity in ulcerative colitis: Single-cell analysis and functional validation of S100A4 as a therapeutic target.
Li Y, Wang Y, Chen S, Liu L
International immunopharmacology 2026 Jan 1;168(Pt 1):115819
International immunopharmacology 2026 Jan 1;168(Pt 1):115819
STING deficiency alleviates ischemia-reperfusion injury via JAK2/STAT3-mediated macrophage polarization and autophagy.
Zhang Y, Jing Y, Liao H, Ding K, Zhang L, Liao S, Kadier T, Chen R, Meng Q
International immunopharmacology 2026 Jan 1;168(Pt 1):115784
International immunopharmacology 2026 Jan 1;168(Pt 1):115784
Developmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition.
Tao M, Wang L, Chen C, Tang M, Wang Y, Zhang J, Zhao X, Feng Q, Chen J, Yan W, Lin R, Fu Y
Journal of advanced research 2026 Feb;80:593-608
Journal of advanced research 2026 Feb;80:593-608
Ascorbate elastomer-coated ePTFE grafts inhibit neointimal hyperplasia and enhance vascular healing.
Yu L, Newton ER, Gillis DC, Cooley BC, Sun K, Dandurand BR, Siletzky R, Tsihlis ND, Kibbe MR
Bioactive materials 2026 Feb;56:726-742
Bioactive materials 2026 Feb;56:726-742
Transcutaneous Auricular Vagus Nerve Stimulation Ameliorates Heart Failure with Preserved Ejection Fraction Through Regulating Macrophage Polarization Mediated by Alpha7nAChR.
Huo JY, Hou C, Jia F, Xue C, Li XL, Yang L, Jiang WY, Zhang X
Cardiovascular drugs and therapy 2026 Feb;40(1):127-140
Cardiovascular drugs and therapy 2026 Feb;40(1):127-140
Targeted inflammatory microenvironment remodeling and NIR-II photothermal therapy for abdominal aortic aneurysm.
Liu Y, Qiu P, Hao H, Ding A, Wu Z, Lei J, Peng Z, Pu H, Zeng C, Guo H, Wu X, Lu H, Qin J, Wang R, Liu H, Ye K, Lu X
Materials today. Bio 2026 Feb;36:102770
Materials today. Bio 2026 Feb;36:102770
Pressure-sensitive composite bandages with high toughness, self-healability and strong tissues adhesion for rapid bone fixation and accelerated osteogenesis via immunomodulation and neovascularization.
Lei P, Wang S, Chen K, Wang L, Shen Y, Zhong H, Chen S, Su X, Zhao Y, Wang H, Li L
Materials today. Bio 2026 Feb;36:102730
Materials today. Bio 2026 Feb;36:102730
4D-printed Fe3O4-PLLA scaffolds modulate osteoimmune microenvironment for oral bone repair.
Song W, Huang W, Du Z, Xiao C, Qu J, Xu W, Liu X
Materials today. Bio 2026 Feb;36:102691
Materials today. Bio 2026 Feb;36:102691
Omentin-1 promotes diabetic wound healing by regulating macrophage efferocytosis and M2 polarization.
Huang Y, Ding X, Dong Z, Ding Y, Chen Y, Zou H, Chen J, Yang P, Chen T, Ma Z, Tan Q
International journal of biological macromolecules 2026 Feb;347:150757
International journal of biological macromolecules 2026 Feb;347:150757
Self-adaptive covalent coating for vascular stents: Coordinated coagulation-inflammation regulation to support re-endothelialization for atherosclerosis control.
Wang Y, Zhu Q, Chen Z, Wang X, Ma B, Wang Y, Xiao Y, Luo R, Zhang W, Wang Y, Fu G
Biomaterials 2026 Feb;325:123600
Biomaterials 2026 Feb;325:123600
Lycium barbarum Polysaccharide Alleviates Renal Damage in Mouse Sepsis by Regulating M1/M2 Macrophage Polarization.
Zhang Y, Lu X, Yang H, Zhao Y, Liu S
Food science & nutrition 2026 Feb;14(2):e71561
Food science & nutrition 2026 Feb;14(2):e71561
Reducing Neuroinflammation via Inhibition of Fibrinogen Deposition and Microglial Activation as an Underlying Mechanism of Paning I Decoction in Ameliorating Parkinson's Disease Symptoms.
Chen YJ, Chen JW, Xie MR, Wang RZ, Wan YL, Zeng J, Zhong BW, Zhou SQ, Liu F
Immunity, inflammation and disease 2026 Feb;14(2):e70310
Immunity, inflammation and disease 2026 Feb;14(2):e70310
Inhalation of mesenchymal stromal cell-derived extracellular vesicles activates macrophage polarization through the miR-22-3p/NLRP3/IL-1β pathway, ameliorating lung ischemia - reperfusion injury.
Wang T, Wu G, Gao P, Zhuang F, Wang Z, Zhou Z, Li C, Wu J, Zhao D
Stem cell research & therapy 2026 Feb 9;17(1)
Stem cell research & therapy 2026 Feb 9;17(1)
ICAM2 loss drives 5-fluorouracil resistance via TGF-β/Smad/SP1/PTN-dependent apoptosis evasion and macrophage remodeling in gastric cancer.
Tang XC, Chen ZJ, Chen CY, Qiu J, Huang JT, Tan RC, Li WY, Chen H, Yang ZL
World journal of gastroenterology 2026 Feb 7;32(5):115301
World journal of gastroenterology 2026 Feb 7;32(5):115301
Treadmill running modulates infrapatellar fat pad remodeling in osteoarthritic rats in an intensity-dependent manner.
Chen Z, Li G, Deng H, Hu Z, Wang Q, He Z
BMC sports science, medicine & rehabilitation 2026 Feb 5;18(1)
BMC sports science, medicine & rehabilitation 2026 Feb 5;18(1)
TRPV1 manipulating polarization of M1/M2 macrophages to promote skeletal muscle regeneration.
Liu J, Li N, Jing S, Wu F, An G, Wang L, Li J, Cao X, Sun J
Skeletal muscle 2026 Feb 3;16(1)
Skeletal muscle 2026 Feb 3;16(1)
Succinate Mediates Immune-Angiogenic Response by Activating Macrophage M2 Polarization in Oxygen-Induced Retinopathy.
Shen T, Lin R, Zheng T, Yu J, Cai W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71545
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71545
Integration of Bulk and Single-Cell Transcriptomics Reveals Prognostic and Immunological Roles of MTHFD2 in Clear Cell Renal Cell Carcinoma.
Zhou Y, Zheng X, Ye P, Yang H
International journal of molecular sciences 2026 Feb 20;27(4)
International journal of molecular sciences 2026 Feb 20;27(4)
Phosphoglycerate dehydrogenase-mediated serine reprogramming aggravates macrophage hyperinflammation in murine Pseudomonas aeruginosa pneumonia.
Chen R, Zeng R, Shi M, Zhang G, Wang F, Yang Q, Jiang Y, Zhang Y, Li Y, Qu J
Nature communications 2026 Feb 20;17(1)
Nature communications 2026 Feb 20;17(1)
AIF-1 Drives Corneal Neovascularization by Promoting Inflammatory Macrophage Activation via the MAPK and PI3K/AKT/mTOR Signaling Pathways.
Li Q, Bao Q, Wei C, Xie Y, Zhao S, Yan H, Wu F, Li W, Liu X, Gao H
Investigative ophthalmology & visual science 2026 Feb 2;67(2):22
Investigative ophthalmology & visual science 2026 Feb 2;67(2):22
The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation.
Zhang H, Fu J, Guo Y, Liu S, Mei X, Zeng X, Ren W
Cell chemical biology 2026 Feb 19;33(2):169-182.e5
Cell chemical biology 2026 Feb 19;33(2):169-182.e5
Ultraviolet-induced Glycyrrhiza polysaccharide hydrogels with different mechanical strength for wound management.
Wang Z, Luo M, Ni L, Li Y, Liu D, Zhu H, Xia B, Liu Y, Liu Q, Yang B
Carbohydrate polymers 2026 Feb 15;374:124712
Carbohydrate polymers 2026 Feb 15;374:124712
Luteolin-Loaded TGN/RAP12 Dual-Peptide Functionalized Nanoparticles: Synergistic Enhancement of BBB Penetration and Microglia Targeting in Alzheimer's Disease.
Liu S, Xing Y, Na Y, Wu H, Liu C, Wang Z, Zhang N, Wu X, Geng F
Molecules (Basel, Switzerland) 2026 Feb 15;31(4)
Molecules (Basel, Switzerland) 2026 Feb 15;31(4)
Houttuynia cordata Polysaccharide Alleviates Hepatic Ischemia-Reperfusion Injury by Regulating Macrophage Polarization via Inhibiting the TLR4/NF-κB Signaling Pathway.
Yu B, He D, Chen Z, Zhou Y, Zhou J, Wang T, Qiu Q, Chen Z, Ma X, Zhu J, Zheng S, Qiu T
Biomedicines 2026 Feb 14;14(2)
Biomedicines 2026 Feb 14;14(2)
An immunomodulatory hydrogel featuring antibacterial and ROS-scavenging functions for enhanced burn wound healing.
Zhao XS, Zhang LP, Wang G, Yang QY, Cheng XJ, Wu CY, Wu D, Dong CB, Yang YT, Wang YF, Cai XJ, Zhu NW
Journal of nanobiotechnology 2026 Feb 13;24(1)
Journal of nanobiotechnology 2026 Feb 13;24(1)
Jianpi-huayu Decotion regulates TREM1/DAP12 pathway to improve the immunosuppressive tumor microenvironment and enhance the anti-hepatocellular carcinoma effect of PD-1 inhibitors.
Yao R, Zhang Y, Yu W, Chen X, Shi H, Luo R, Fang C, Zhao X, Zhu X, Lai Y, Xiao S, Chen Y, Zhang J, Zhong C
Journal of ethnopharmacology 2026 Feb 10;356:120846
Journal of ethnopharmacology 2026 Feb 10;356:120846
Hypoxia-preconditioned cardiomyocyte-derived extracellular vesicles alleviate myocardial ischemic injury by reprogramming macrophage polarization via the Fgl2/NF-κB pathway.
Zhang Z, Shen H, Zhang S, Zhou J, Zhang M, Wang Y, Zheng Y, Chang Y, Liang X, Hu X, Gao W
International immunopharmacology 2026 Feb 1;170:116077
International immunopharmacology 2026 Feb 1;170:116077
Sensory neuron TRPV1-mediated macrophage polarization and immune response regulate dental implant osseointegration.
Jiang Y, Wang B
Tissue & cell 2026 Apr;99:103243
Tissue & cell 2026 Apr;99:103243
Bacteria-responsive DNAgel system for targeted delivery of photothermally enhanced MXene/MoS(2) in the treatment of pyogenic osteomyelitis.
Jiang Y, Siow L, Xing K, Lin M, Cao Z, Liu Y, Gong J, Zhou S, Gu T, Feng B, Lan R, Gao Y, Yang Y, Zhang C, Lin S, Zhu Z, Leong DT, Yu M
Bioactive materials 2026 Apr;58:123-138
Bioactive materials 2026 Apr;58:123-138
Mesoporous bioactive glass hybrid nanoparticles accelerate tendon-bone healing via synergistic angiogenesis and immunomodulation.
Chen Y, Yao H, Li C, Zhou Y, Ren J, Liu R, Wei J, Hao L
Materials today. Bio 2026 Apr;37:103004
Materials today. Bio 2026 Apr;37:103004
MicroRNA-493-5p engineered exosomes delivered via piezoelectric microneedles for epigenetic modulation of macrophages in diabetic wound healing.
Chen T, Ouyang L, Mi B, Sheng Y, Al-Smadi F, Xu H, Wu Y, Zhang X, Zhou K, Wu A, Wang X, Liu G, Zhang W
Materials today. Bio 2026 Apr;37:102931
Materials today. Bio 2026 Apr;37:102931
Dual-responsive PDA-HP hydrogel enables mitochondria-targeted mild photothermal therapy for spinal cord repair.
Li Y, Hu J, Ran B, Zhong H, Zhong N, Zhong Y, Fu X, Liu X, Wu G, Zhong Q, Li J
Materials today. Bio 2026 Apr;37:102783
Materials today. Bio 2026 Apr;37:102783
Expanded screening and analysis of Photorhabdus virulence cassette (PVC) signal peptides reveals an anti-phagocytotic effector.
Wang Y, Bai X, Nachmias N, Zhang Y, Feng X, Levy A, Jiang F
International journal of biological macromolecules 2026 Apr;354:151308
International journal of biological macromolecules 2026 Apr;354:151308
ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.
Tai C, Ling C, Yang Y, Mo N, Yao C, Lv S, Zhang B, Wang H, Chen C
CNS neuroscience & therapeutics 2026 Apr;32(4):e70879
CNS neuroscience & therapeutics 2026 Apr;32(4):e70879
The Dual Role of Gastrodin in Spinal Cord Injury: Microglial Phenotype Switching and Neuronal Survival via PI3K/AKT Activation.
Feng J, Gao S, Hu Y, Sheng W
CNS neuroscience & therapeutics 2026 Apr;32(4):e70811
CNS neuroscience & therapeutics 2026 Apr;32(4):e70811
Wine-Processed Cornus officinalis Ameliorates Osteoarthritis via Modulating M1/M2 Macrophage Polarization.
Fu Y, Zhao M, Huang X, Ren Y, Wang W
Journal of cellular and molecular medicine 2026 Apr;30(7):e71113
Journal of cellular and molecular medicine 2026 Apr;30(7):e71113
RUVBL2 Regulates Microglia Metabolic Reprogramming to Mediate Stress Granules Aggregation Exacerbating Postoperative Delirium in Aged Mild Cognitive Impairment Rats.
Zhang L, Wang Z, Yang C, Wang X, Liu X, Zhang H, Liu H, Liao H, Chen J, Wang H
Aging cell 2026 Apr;25(4):e70458
Aging cell 2026 Apr;25(4):e70458
Parthenolide ameliorates inflammation in sepsis via covalently targeting Trim33 and inhibiting NF-κB pathway.
He X, Wang C, Zhang R, Wang Y, Zhang Y, Yang T, Zhang J, Rao S, Tang H, Peng X, Wang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157862
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157862
Zinc-Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing.
Sun R, Wei X, Song Z, Luo J, Ye J, Zhang Y, Zhu L, Gao J, Zhang H, Zhu H, Wang X, Xu K
Advanced healthcare materials 2026 Apr;15(15):e05663
Advanced healthcare materials 2026 Apr;15(15):e05663
Hierarchical Targeting of TREM2(+) Myeloid Cells via Acid-Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone-Metastatic TNBC.
Chen F, Xue Y, Ma X, Chen L, Shao Z, Sun H, Mou H, Wang F, Li Z, Shen Y, Ye Z, Yu X, Wang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 7;:e17369
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 7;:e17369
Longitudinal Single-Cell RNA-seq Profiling of Lung Cell Phenotypes, Signaling, and Cross-talk During Fibrosis Resolution.
Speth J, Wong VT, Guzman SD, Liu Y, Walker NM, Zemans RL, Blackwell TS, Aguilar CA, Peters-Golden M, Fortier SM
bioRxiv : the preprint server for biology 2026 Apr 7;
bioRxiv : the preprint server for biology 2026 Apr 7;
Ubiquitously expressed prefoldin-like chaperone (UXT) regulates putrescine metabolism and promotes colorectal cancer progression.
Chen M, Huang S, Gong L, Wu X, Li Y, Wu H
Human cell 2026 Apr 3;39(4)
Human cell 2026 Apr 3;39(4)
Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1-Mediated M1 Macrophage Polarization in Sarcoidosis.
Liu M, Han Y, Xie B, Zhu L, Xu W, Han Y, Liao Y, Gao S, Jiang D, Geng J, Li Z, Hu Y, Dai H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 3;:e20635
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 3;:e20635
Shionone Alleviates Sepsis-Induced Acute Lung Injury by Regulating Macrophage Polarization Through the HMGB1/NF-κB Pathway.
Wu Q, Xi G, Lin Y, Zhao J, Song Y, Jiang H, Zhang B
Frontiers in bioscience (Landmark edition) 2026 Apr 22;31(4):49062
Frontiers in bioscience (Landmark edition) 2026 Apr 22;31(4):49062
Xuming tongmai decoction modulates astrocyte polarization and mitophagy via the PINK1/Parkin pathway in a rat model of acute ischemic stroke.
Ran L, Lan X, Zeng Z, Yu X, Yang R, Tang J
Brain research 2026 Apr 15;1877-1878:150203
Brain research 2026 Apr 15;1877-1878:150203
Ginsenoside Rg3 synergizes with near-infrared photothermal therapy to suppress prostate cancer progression by inhibiting RAS signaling and enhancing ARL11-mediated macrophage reprogramming.
Zhang H, Chang Y, Fu Q, Jin T, Zhang S, Zhang M
International immunopharmacology 2026 Apr 15;175:116417
International immunopharmacology 2026 Apr 15;175:116417
Platelet factors 4 produces an antidepressant effect in mice via inhibition of neuroinflammation.
Li YH, Zhan JQ, Zhao Y, Ouyang ZY, Luo LQ, Wei B, Yang YJ
Journal of advanced research 2026 Apr 15;
Journal of advanced research 2026 Apr 15;
Targeting Smad3 Phosphorylation Attenuates Anastomotic Intimal Hyperplasia and Perigraft Fibrosis in Decellularized Tissue-Engineered Vascular Grafts.
Lu P, Wang T, Liao S, He Z, Cheng S, Wang T, Cheng Z, An Y, Zhou S, Wang M, Zhang Q, Shu C
Biomaterials research 2025;29:0241
Biomaterials research 2025;29:0241
Ginsenoside Rh2-Pretreated Mesenchymal Stem Cell Exosomes Ameliorate Collagen-Induced Arthritis via N6-Methyladenosine Methylation.
Zhou Z, Wu S, Li Y, Shao P, Jiang J
Biomaterials research 2025;29:0220
Biomaterials research 2025;29:0220
WTAP Maintains Alternative Activation of Macrophages by Promoting IDH1-Mediated α-ketoglutarate Production.
Xu Q, Zhang J, Zou Y, Chen L, Sun F, Luo X, Wang T, Li Y, Zhang S, Xiong F, Yu Q, Yang P, Gong Q, Liu SW, Wang CY
International journal of biological sciences 2025;21(12):5428-5443
International journal of biological sciences 2025;21(12):5428-5443
Orphan Class A GPCRs Signature Predicts Prognosis and Immune Microenvironment in Gastric Cancer: GPR176 Drives Tumor Progression Through Wnt Signaling and Macrophage Polarization.
Lin J, Ke L, Cheng S, Lu W, Hu Y, He X, Luo T, Liu Y, Xu C, Qi J
Mediators of inflammation 2025;2025:7977933
Mediators of inflammation 2025;2025:7977933
Electroacupuncture Improves Ovarian Function in Rats With Tripterygium Glycoside-Induced Diminished Ovarian Reserve by Promoting the Polarization of M2 Macrophages and Inhibiting Inflammatory Responses.
Luo J, Qin Y, Zhu Y, Yin Y, Shen M
Mediators of inflammation 2025;2025:1694470
Mediators of inflammation 2025;2025:1694470
Parthenolide regulates microglial and astrocyte function in primary cultures from ALS mice and has neuroprotective effects on primary motor neurons.
Thau-Habermann N, Gschwendtberger T, Bodemer C, Petri S
PloS one 2025;20(3):e0319866
PloS one 2025;20(3):e0319866
Heme Oxygenase-1 Modulates Macrophage Polarization Through Endothelial Exosomal miR-184-3p and Reduces Sepsis-Induce Lung Injury.
Chen W, Zhang Y, Chen J, Dong S, Wu X, Wu Y, Du Z, Yang Y, Gong L, Yu J
International journal of nanomedicine 2025;20:5039-5057
International journal of nanomedicine 2025;20:5039-5057
Lung Tissue Extracellular Vesicles-Mediated Delivery of miR-128-3p as a Novel Mechanism of Acute Lung Inflammation.
Deng W, Zhu X, Li H, Hu P, Qian K, Liu F
International journal of nanomedicine 2025;20:4831-4848
International journal of nanomedicine 2025;20:4831-4848
Quercetin-Loaded Nanoparticle-Modified Decellularized Tissue-Engineered Vascular Graft Regulates Macrophage Polarization and Promotes In Vivo Graft Remodeling.
Wang T, He Z, Lu P, Liao S, Cheng S, Wang T, An Y, Cheng Z, Shu C
International journal of nanomedicine 2025;20:2761-2778
International journal of nanomedicine 2025;20:2761-2778
Tenascin-C Facilitates Microglial Polarization via TLR4/MyD88/NF-κB Pathway Following Subarachnoid Hemorrhage.
Hu ZQ, Ma R, Sun JQ, Peng M, Yuan J, Lai N, Liu J, Xia D
Journal of inflammation research 2025;18:3555-3570
Journal of inflammation research 2025;18:3555-3570
A stage specific NETs-related signature in alcoholic steatohepatitis: from molecular subtyping to therapeutic vulnerabilities.
Gao W, Lin Z, Bao Y, Liu M, Ma G, Chen X, Yu S, Zeng Y
Frontiers in immunology 2025;16:1711388
Frontiers in immunology 2025;16:1711388
MCP-1/CCR2 axis regulates M2 macrophage polarization and immunosuppression in mycobacterium tuberculosis.
Zhao G, Guo C, Li X, Tan L, Chen X, Tian F, Zhang L, Wang X, Cui J
Frontiers in immunology 2025;16:1698369
Frontiers in immunology 2025;16:1698369
Bone marrow mesenchymal stem cells alleviate smoke inhalation injury by regulating alveolar macrophage polarization via the CD200-CD200R pathway.
Ding Z, Zhuang Y, Zhao Y, Shi J, Guo X, Fan H, Lv Q
Frontiers in immunology 2025;16:1645460
Frontiers in immunology 2025;16:1645460
Machine learning identifies PYGM as a macrophage polarization-linked metabolic biomarker in rectal cancer prognosis.
Xu C, Zhang S, Sun B, Yu Z, Liu H
Frontiers in immunology 2025;16:1639303
Frontiers in immunology 2025;16:1639303
Integrative analysis of single-cell and microarray data reveals SPI1-centered macrophage regulatory signatures in ulcerative colitis.
Yu Y, Yu C, Dai S, Liu Y, Hu L, Lu W
Frontiers in genetics 2025;16:1617834
Frontiers in genetics 2025;16:1617834
miR-223 alleviates DSS-induced colitis by prompting macrophage M2 polarization through PPAR-γ/FOXO1 signaling.
Zhang J, Wang L, Shen Y, Qian X, Wang Z, Wang C
Frontiers in immunology 2025;16:1598781
Frontiers in immunology 2025;16:1598781
Hsa_circ_0058495-mediated IGF2BP2 ubiquitination and m6A modification of MEKK1 promote the progression of PDAC.
Lv S, Zhang J, Peng X, Liu H, Chu T, Liu Z, Duan K, Guo J, Wang J, Liu Y, Wei F
Theranostics 2025;15(18):9922-9943
Theranostics 2025;15(18):9922-9943
Lysyl Oxidase-Like 1 (LOXL1) Up-Regulation in Chondrocytes Promotes M1 Macrophage Activation in Osteoarthritis via NF-κB and STAT3 Signaling.
Jiang Y, Wang S, Zhu W, Liu X, Yang Y, Huo L, Ye J, Ma Y, Zhou Y, Yang Z, Mao J, Wang X
ImmunoTargets and therapy 2025;14:259-278
ImmunoTargets and therapy 2025;14:259-278
The Effects of M2 Macrophages-Derived Exosomes on Urethral Fibrosis and Stricture in Scar Formation.
Ren X, Wang Z, Wang J, Li X, Wei H, Liu C, Liu S, Zhu Y, Feng C, Yin Y, Tian Y, Wu M, Zeng X
ImmunoTargets and therapy 2025;14:151-173
ImmunoTargets and therapy 2025;14:151-173
Decoding HuH-7: a comprehensive genetic and molecular portrait of a widely used hepatocellular carcinoma model.
Luis DD, Liehr T, Kankel S, Weise A, Pentzold C, Buhl EM, Hardt KS, Keller DT, Schröder-Lange SK, Weiskirchen R
Frontiers in cell and developmental biology 2025;13:1648639
Frontiers in cell and developmental biology 2025;13:1648639
The role of astrocyte-derived extracellular vesicles in cellular microenvironment remodeling after spinal cord injury: A study based on quantitative proteomics analysis.
Zhu Z, Xu Y, Wang K, Xu X, Song Y, Zhao B, Ding W, Liu J, Song Z
Experimental neurology 2025 Sep;391:115321
Experimental neurology 2025 Sep;391:115321
Regulation of macrophage phenotypes via NF-κB/NLRP3 and HIF1α/p53 pathways by fuco-galactoglucan from Agrocybe aegerita.
Li X, Shui M, Zhang X, Tang H, Guo H, Gu F, Xu H, Han B, Kou Y
International journal of biological macromolecules 2025 Sep;322(Pt 2):146559
International journal of biological macromolecules 2025 Sep;322(Pt 2):146559
Mycobacterium tuberculosis impairs protective cytokine production via transcription factor MafB manipulation.
Saiga H, Ueno M, Tamura T, Tsujimura Y, Asaka MN, Tsukamoto Y, Mukai T, Hamada M, Takahashi S, Tanaka T, Kaisho T, Takahashi Y, Hoshino K, Ato M
PLoS pathogens 2025 Sep;21(9):e1013476
PLoS pathogens 2025 Sep;21(9):e1013476
Effects of SADS-CoV accessory proteins NS3a, NS7a, and NS7b on viral pathogenicity: A multi-omics investigation.
Yan X, Zhang X, Zhou L, Zhao X, Li Q, Lan T, Fu J, Ma J
iMetaOmics 2025 Sep;2(3):e70015
iMetaOmics 2025 Sep;2(3):e70015
Piezoelectric-IL-4 programmed regulation of immuno-microenvironment-induced mesenchymal stem cell recruitment and differentiation for bone regeneration.
Zhang J, Wang W, Wang M, Hai H, Li K, Wang L, Lei M, Cui L, Liu H, Guo J, Liu C
Ultrasonics sonochemistry 2025 Sep;120:107431
Ultrasonics sonochemistry 2025 Sep;120:107431
A Myelin Debris Cleaner for Spinal Cord Injury Recovery: Polycaprolactone / Cell Membrane Assembled Scaffolds.
Zhou Y, Xu T, Zhou Y, Chen N, Wu Z, Yang Z, Yang C, Chen X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e03269
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e03269
Multidimensional Engineering of Extracellular Vesicles for Targeted Delivery and Microglial Reprograming in Spinal Cord Injury Repair.
Xiong W, Liu M, Wang J, Liu J, Zheng M, Chan P, Zhu Q, Li C, Kong G, Tang C, Fan J
ACS nano 2025 Sep 9;19(35):31551-31571
ACS nano 2025 Sep 9;19(35):31551-31571
Inhibition of Dectin-1 alleviates inflammation in early diabetic retinopathy by regulating microglia phenotype.
Sang W, Zhang X, Hu Q, Jiang B, Guan J, Huang Z, Sun L, Sun D
Gene 2025 Sep 5;963:149572
Gene 2025 Sep 5;963:149572
METTL14 knockdown augmented the polarization of M2-like macrophages to promote acute myeloid leukemia progression.
Wang M, Xie Z, Tan Y, Zhou Y, Wang S, Zhang P, Li J
Human cell 2025 Sep 30;38(6):168
Human cell 2025 Sep 30;38(6):168
Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling.
Guo M, Yuan Z, Jin X, Li X, Deng Y, Zhou S, Niu R, Bae J, Park JB, Shi B, Yin J
Nature communications 2025 Sep 30;16(1):8642
Nature communications 2025 Sep 30;16(1):8642
Rhodiola tangutica (maxim.) S. H. Fu protects blood-retinal barrier in hypoxia-induced retinal injury rats by down-regulating HIF-1α/eNOS/NO pathway.
Li N, Luo Y, Liu X, Tan D, Li Z
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120325
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120325
Breviscapine regulates lipid metabolism of microglia via the ADORA1/PPARα/ACOX1 pathway to promote spinal cord injury recovery.
Shi F, Wang S, Wu C, Wen H, Zhou W
International immunopharmacology 2025 Sep 23;162:115145
International immunopharmacology 2025 Sep 23;162:115145
Vitamin D against diabetic adipose tissue inflammation through SHP-1/STAT3 pathway.
Wei X, Wang Y, Liu W, Zhang D, Zhou C, Jiang Z, Li W, Li X, Miao Y
International immunopharmacology 2025 Sep 23;162:115131
International immunopharmacology 2025 Sep 23;162:115131
Artesunate suppresses ocular inflammation in endotoxin-induced uveitis through inhibiting the NF-κB signaling pathway and M1 macrophage polarization.
Liu L, Hao X, Lu B, Li X, Xie L
European journal of pharmacology 2025 Sep 15;1003:177947
European journal of pharmacology 2025 Sep 15;1003:177947
Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice.
Liu Y, Han X, Su Y, Zhou Y, Xu M, Xu J, Ma Z, Gu X, Xia T
Neural regeneration research 2025 Sep 1;20(9):2727-2736
Neural regeneration research 2025 Sep 1;20(9):2727-2736
Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.
Zhang M, Liu S, Wu Z, Wang C, Zhang H, Yang J, Guo C, Dai M, Wang X, Ren W
Science China. Life sciences 2025 Oct;68(10):3037-3050
Science China. Life sciences 2025 Oct;68(10):3037-3050
Catalyst-modulated hydrogel dynamics for decoupling viscoelasticity and directing macrophage fate for diabetic wound healing.
Mai Y, Wang H, Lu J, Shi S, Cai Y, Zhang W, Xie S, Huang R, Ji S, Qu X
Bioactive materials 2025 Oct;52:878-895
Bioactive materials 2025 Oct;52:878-895
One-step strategy for fabricating icariin-encapsulated biomimetic Scaffold: Orchestrating immune, angiogenic, and osteogenic cascade for enhanced bone regeneration.
Zhao F, Chen F, Song T, Tian L, Guo H, Li D, Yang J, Zhang K, Xiao Y, Zhang X
Bioactive materials 2025 Oct;52:271-286
Bioactive materials 2025 Oct;52:271-286
On-Demand ER Stress Modulation in Tumor Cells and TAMs via an Adaptively Transformable Nanoplatform Enhances Photodynamic Immunotherapy.
Zhao B, Chen X, Xu S, Xing Y, Shao J, Xiao Y, Qi J, Qian H, Huang D, Chen W, Zhong Y
Advanced materials (Deerfield Beach, Fla.) 2025 Oct;37(42):e07299
Advanced materials (Deerfield Beach, Fla.) 2025 Oct;37(42):e07299
Dual stimulus-responsive dECM cryogel sequentially regulate bone microenvironment for one-step surgical therapy of chronic osteomyelitis.
Liu H, Liu S, Liao L, Liao H, Pan W, Hu J
Materials today. Bio 2025 Oct;34:102243
Materials today. Bio 2025 Oct;34:102243
A multifunctional self-assembled hydrogel with bactericidal activity and macrophage metabolic reprogramming for diabetic bone defect repair.
Wang L, Wu Z, Chen X, Bai J, Li W, Ge G, Zhang W, Li W, Qin Y, Zhao G, Wang Y, Pan G, Xu Y, Geng D
Materials today. Bio 2025 Oct;34:102162
Materials today. Bio 2025 Oct;34:102162
Chiral gold nanoparticles manipulate osteoimmune microenvironment via macrophage autophagy for bone regeneration.
Wang J, Gao N, Wei J, Liao L
Materials today. Bio 2025 Oct;34:102131
Materials today. Bio 2025 Oct;34:102131
Translating m6A-Glycolysis Discovery into Therapy: GOQD-Based Multifunctional Bioactive Scaffolds Rejuvenates Bone Repair in Senescence.
Wang Z, Deng T, Chang H, Li Y, Zhang Y, Jiao X, Gan Y
Small (Weinheim an der Bergstrasse, Germany) 2025 Oct;21(43):e07315
Small (Weinheim an der Bergstrasse, Germany) 2025 Oct;21(43):e07315
From Molecular Docking to Rat Models: Butyrate From a High-Fiber Diet Inhibits HDAC1 and NLRP3 Inflammasome to Alleviate Oxidative Stress and Inflammation After Spinal Cord Injury.
Ganggang K, Cheng G, Gang L, Wenwu Z, Di Z, Yan L, Baoshu X, Yiqin W
Journal of neurochemistry 2025 Oct;169(10):e70250
Journal of neurochemistry 2025 Oct;169(10):e70250
miR-21-5p Alleviates Retinal Ischemia-Reperfusion Injury by Inhibiting M1 Polarization of Microglia via Suppression of STAT3 Signaling.
Qin L, Liao J, Tan C, Liu C, Shi W, Chen D
Biomedicines 2025 Oct 9;13(10)
Biomedicines 2025 Oct 9;13(10)
Dental pulp stem cells promote the recovery of spinal cord injury by regulating microglia polarization via JAK2/STAT3 signaling pathway.
Yang T, Tang S, Feng W, Li Z, Liu X, Cheng C, Wei F, Ding G
International immunopharmacology 2025 Oct 30;164:115395
International immunopharmacology 2025 Oct 30;164:115395
MYCN-mediated pyroptosis and inflammation in the molecular mechanism of MicroRNA-202-3P promote functional recovery in spinal cord injury.
Fang J, Huang K, Zhang G, Shi B, Bi H, Shuai L
International immunopharmacology 2025 Oct 30;164:115349
International immunopharmacology 2025 Oct 30;164:115349
Synergistic potential of Berberine and Wogonin improved adipose inflammation and insulin resistance associated with obesity through HIF-α axis.
Zhou Z, Wang M, Zhang X, Xu Y, Li P, Zheng Z, Yang H
Chinese medicine 2025 Oct 3;20(1):155
Chinese medicine 2025 Oct 3;20(1):155
Amelioration of renal injury by Qihuang Jianpi Zishen Granules in lupus mice is correlated with AMPK/ULK1-dependent modulation of macrophage polarisation.
Qian A, Hu K, Zhu Y, Cheng Y, Li M, Huang C
Lupus science & medicine 2025 Oct 29;12(2)
Lupus science & medicine 2025 Oct 29;12(2)
Mesenchymal stem cell extracellular vesicles ameliorate radiation-caused dry mouth via modulating immune balance and cell metabolism.
Jaiswal J, Zhao Q, Shahsavari A, Ibrahim MJ, Chang E, Zhang Y, Yu V, Zheng R, Wewel E, Chen T, Baetge CL, Deveau MA, Liu F
Stem cell research & therapy 2025 Oct 24;16(1):579
Stem cell research & therapy 2025 Oct 24;16(1):579
M2-exo promote orthodontic bone remodeling via the MeCP2-TCF20-HDAC1 axis.
Chen M, Li Y, Yang Z, Chen M, Li J, Bao G, Ma L, Hu J
Stem cell research & therapy 2025 Oct 15;16(1):569
Stem cell research & therapy 2025 Oct 15;16(1):569
A cell-free TLR5(high) MSC membrane nanoparticle therapy for Crohn's disease: Targeted immunomodulation via the flagellin/TLR5 axis.
Xie Y, Li Y, Xu C, Zhang W, Jiang Y, Wang L, Tang Y, Sun Q, Yang H, Mai X, Shen P, Wang B
Journal of controlled release : official journal of the Controlled Release Society 2025 Oct 10;386:114121
Journal of controlled release : official journal of the Controlled Release Society 2025 Oct 10;386:114121
Fe-MOF loaded with capmatinib to reverse immunosuppressive microenvironment and inhibit tumor metastasis after radiofrequency ablation.
Zhao J, Lei L, Zeng C, Zhou X, Ding J, Dai W, Jiang A, Zou S, Jin Q, Tang Z
Journal of nanobiotechnology 2025 Oct 10;23(1):648
Journal of nanobiotechnology 2025 Oct 10;23(1):648
TFAP4/DLGAP5 promotes tumor progression and macrophage M2 polarization in prostate cancer by activating the JAK2/STAT3 signaling.
Li S, Dong Q, Ren W, Sun Y, Wang Z, Pan L
Experimental cell research 2025 Oct 1;452(2):114753
Experimental cell research 2025 Oct 1;452(2):114753
Effects of Sapropterin against Non-Alcoholic Fatty Liver Disease in mice.
Jiang J, Hu Z, Li L
Immunological investigations 2025 Nov;54(8):1542-1560
Immunological investigations 2025 Nov;54(8):1542-1560
Characterization of Periplaneta americana glycoproteins' structures and their potential to treat immunological liver fibrosis.
Li K, Yang X, Chen Z, He R, Wan J, Yang Y, Shi G, Xiao P
International journal of biological macromolecules 2025 Nov;329(Pt 2):147900
International journal of biological macromolecules 2025 Nov;329(Pt 2):147900
Innovative DNA tetrahedron inspired by ancient mortise-and-tenon technique offers new immunotherapy strategy for metastatic breast cancer.
Zhang N, Qian L, Xu C, Duan F, Ma Y, Zhou L, Zhang Y, Ma Y, Lin Q, Lu K
Biomaterials 2025 Nov;322:123390
Biomaterials 2025 Nov;322:123390
Galectin-9 promotes colon cancer development by polarizing macrophages toward the M2 phenotype.
Zhang J, Xu Y, Han X, Gao Y, Wei Z, Sun X
Cancer genetics 2025 Nov;298-299:141-150
Cancer genetics 2025 Nov;298-299:141-150
Interleukin-10 Modified Human Mesenchymal Stromal Cells Markedly Alleviated Periodontitis by Inducing Macrophage M2 Polarisation.
Heinayati A, Jiang X, Gao T, Wang L, Wang B, Qin H
Journal of cellular and molecular medicine 2025 Nov;29(21):e70934
Journal of cellular and molecular medicine 2025 Nov;29(21):e70934
TAS4464, a neddylation inhibitor, mitigates Staphylococcus aureus-induced periprosthetic joint infection by modulating immunosuppressive cell functions.
Peng KT, Chen JL, Hsieh YC, Hsiao CY, Yang CC, Liu JF, Lee CW, Chiang YC, Chang PJ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Nov;192:118622
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Nov;192:118622
AMPK upregulates SOCS1 to promote TFEB nuclear transfer, enhances autophagy, inhibits macrophage M1 polarization and relieves acute lung injury.
Nie W, Gong C, Liu Y, Yang J, Dai Q, Liao Y, Li F
Molecular immunology 2025 Nov;187:240-253
Molecular immunology 2025 Nov;187:240-253
eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR-Mediated Metabolic Rewiring.
Mittal S, Nenwani M, Pulikkal Kadamberi I, Kumar S, Animasahun O, George J, Tsaih SW, Gupta P, Singh M, Geethadevi A, Dey C, Meurs N, Shankaran A, Chaluvally Raghavan P, Nagrath D, Pradeep S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e06307
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e06307
RRBP1 Inhibition Reduces Microglial M1 Polarization and Inflammation-Mediated Neuronal Loss and Oxidative Stress by Regulating ERK Pathway in Alzheimer's Disease.
Li Y, Fan H, Han X, Ni M, Hou X, Xia H, Shi Y, Zhang L, Sun J
Molecular neurobiology 2025 Nov 6;63(1):5
Molecular neurobiology 2025 Nov 6;63(1):5
A mitochondria-targeted nanomedicine for myocardial ischemia/reperfusion injury with synergistic antioxidant and anti-inflammatory properties.
Li C, Zhang Z, Luo C, Lan W, Liu C, Liu W, Xiang H, Yang J, Tang Y, Wang X
Journal of nanobiotechnology 2025 Nov 5;23(1):705
Journal of nanobiotechnology 2025 Nov 5;23(1):705
Rg1-preconditioned adipose-derived mesenchymal stromal cells alleviate colitis via exosome-mediated Inhibition of macrophage glycolysis through RAS signaling.
Fang Y, Chen Y, Yu X, Zhang J, Zhu W, Mou C, Wang D, Chen A, Zhang R, Liu Q, Li T, Jiang B
Stem cell research & therapy 2025 Nov 28;17(1):68
Stem cell research & therapy 2025 Nov 28;17(1):68
The Leupaxin/HDAC6/EGR2 axis facilitates breast cancer progression by enhancing macrophage M2 polarization.
He S, Wang Q, He J, Chen Z, Xiao Y
Cell biology and toxicology 2025 Nov 25;41(1):154
Cell biology and toxicology 2025 Nov 25;41(1):154
Urolithin B promotes the functional recovery of spinal cord injury by alleviating neuroinflammation via the inhibition of NLRP3 signaling pathway.
Su Y, Wang H, Yang W, Zhang S, Liu F, Han K, Guan F, Ma S, Cui Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157331
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157331
M2 macrophages and tumor cells engage in a metabolic feedback loop to drive HCC progression.
Nong Y, Chen X, Zhang B, Lin Z, Wuriniletu, Du C, Liu Q
Scientific reports 2025 Nov 24;15(1):41701
Scientific reports 2025 Nov 24;15(1):41701
The miR-125a-5p/IRF4 Axis Mediates Sodium Arsenite-Induced M2 Macrophage Polarization.
Yu Y, Yao F, Tong S, Li M, Liao Q, Wang F, Xi S
Biomolecules 2025 Nov 20;15(11)
Biomolecules 2025 Nov 20;15(11)
Gallic Acid Alleviates Cerebral Ischemia-reperfusion Injury in Mice by Mediating Microglial Polarization Through the NLRP3/mTOR Axis.
Hua W, Xu H, Chen R, Zhang H, Zhang Y, Zhang X, Zhang Y, Liu J, Zhang L, Yang P
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Nov 10;20(1):101
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Nov 10;20(1):101
Application of Dental Pulp Stem Cell-Derived Intracellular Vesicles for Diabetic Wound Healing.
Pang P, Liu Y, Song H, Ye Z, Zhou H, Zhang R, Kumeria T, She W, Xu C, Mei PL, He Y, Ye Q
Diabetes 2025 Nov 1;74(11):2060-2074
Diabetes 2025 Nov 1;74(11):2060-2074
Ultrasound-triggered injectable piezoelectric nanocomposite hyaluronic acid-based hydrogel for modulating inflammation and chondrogenesis in osteoarthritis treatment.
Lin J, Li S, Peng Y, Qiu C, Yang M, Guo J, Yu B, Chen Y
Carbohydrate polymers 2025 Nov 1;367:123909
Carbohydrate polymers 2025 Nov 1;367:123909
Hydroxysafflor yellow A attenuates the blood-brain barrier dysfunction and neuroinflammation through anti-inflammatory microglial polarization after intracerebral hemorrhage.
Zheng F, Guo X, Yan Q, Zhou Y, Hu E, Zhu H, Cheng M, Yu Z, Hu M, Ding R, Li H, Zhang W, Tang T, Wang Y, Li T, Deng C
Neuropharmacology 2025 Nov 1;278:110576
Neuropharmacology 2025 Nov 1;278:110576
Th22 cells promote the transition from homeostatic to reactive microglia in diabetic encephalopathy.
Yu SX, Yu HD, Wang YF, Yao TF, Lv SZ, Wang YC, Li JQ, Liu WQ, Ding JY, Liu XZ, Zuo ZF, Liu WP
Acta diabetologica 2025 May;62(5):633-650
Acta diabetologica 2025 May;62(5):633-650
Succinate Activates Uncoupling Protein 2 to Suppress Neuroinflammation and Confer Protection Following Intracerebral Hemorrhage.
Wang Y, Huang C, Wang X, Cheng R, Li X, Wang J, Zhang L, Li F, Wang H, Li X, Li Y, Xia Y, Cheng J, Pan X, Jia J, Xiao GD
Antioxidants & redox signaling 2025 May;42(13-15):687-710
Antioxidants & redox signaling 2025 May;42(13-15):687-710
Dectin-1 participates in neuroinflammation and dopaminergic neurodegeneration through synergistic signaling crosstalk with TLR4.
Xue F, Zhang M, Zhao RY, Wang XW, Gu Y, Yang Y, Chen WF
Brain, behavior, and immunity 2025 May;126:260-273
Brain, behavior, and immunity 2025 May;126:260-273
Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization.
Qiu H, Liu J, You J, Zhou O, Hao C, Shu Y, Ma D, Zou W, Zhang L, Liu E, Luo Z, Ren L, Geng G, Zou L, Peng D, Fu Z
Genes & diseases 2025 May;12(3):101244
Genes & diseases 2025 May;12(3):101244
Enhancing Tendon Regeneration: Investigating the Impact of Topography on the Secretome of Adipose-Derived Stem Cells.
Long Q, Liu C, Zheng H, Wang M, Liu H, Liu Y, Cao Z, Sun Y, Mo Q, Backman LJ, Zhu J, Hu L, Huang J, Zhang W, Chen J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(18):e2417447
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(18):e2417447
GTS-21 alleviates sepsis-induced atrial fibrillation susceptibility by modulating macrophage polarization and Neuregulin-1 secretion.
Zhou J, Wu K, Ma Y, Zhu J, Zhou Y, Zhang Z, Li F, Zeng G, Li S, Tan S, Zhang Y, Wan C, Tu T, Lin Q, Liu Q
International immunopharmacology 2025 May 8;154:114561
International immunopharmacology 2025 May 8;154:114561
Comparison of the Immunomodulatory Roles of Porcine Milk-Derived Extracellular Vesicles from Different Stages of Lactation.
Wang H, Wang Y, Ling M, Wang S, Luo J, Sun J, Xi Q, Chen T, Zhang Y
Journal of agricultural and food chemistry 2025 May 21;73(20):12247-12260
Journal of agricultural and food chemistry 2025 May 21;73(20):12247-12260
Toxoplasma calcium-dependent protein kinases 3 mediates M1 macrophage polarization by targeting host Arginase-1.
An R, Liu F, Dai N, Li F, Liu X, Cai H, Chen L, Du J
Parasites & vectors 2025 May 20;18(1):181
Parasites & vectors 2025 May 20;18(1):181
Herkinorin ameliorates neuronal damage in a pentylenetetrazol-induced epilepsy rat model through altering microglial and astrocytic activation by inhibiting PARP1 and NF-κB.
Liu Y, Zhao W, Lv X, Wu G, Zhou X, Tian H, Qv X, Sun H, He Y, Zhang Y, Wang C, Tian J
International immunopharmacology 2025 May 16;155:114588
International immunopharmacology 2025 May 16;155:114588
IL-27 accelerates diabetic wound healing by modulating macrophage polarization.
Tao L, Wu S, Wang Q, Xi Z, Zou Y, Cao M, Liang K, Xu W, Hu Q, Ge Y, Yin Z, Ju Z, Liu Z
International immunopharmacology 2025 May 16;155:114575
International immunopharmacology 2025 May 16;155:114575
Astragaloside IV prevents liver fibrosis by blocking glycolysis-mediated macrophage M1 polarization.
Hu Y, Kuang M, Song H, Tan Y, Zhou F, Pei G, Jiao L
European journal of pharmacology 2025 May 15;995:177353
European journal of pharmacology 2025 May 15;995:177353
Anemarrhena asphodeloides Bunge and Phellodendri Chinensis Cortex inhibits the PTGS2/EP2/cAMP/Epac1 signaling pathway to reduce microglial M1 polarization, thereby blocking chronic stress-induced depression-like behavior.
Zhao DP, Xue A, Yuan K, Zuo K, Li Y, Bian ZH, Xu HD, Cheng SM, Yang M, Zhao HM, Ma X, Lei X, Zhang N
Journal of ethnopharmacology 2025 May 12;347:119792
Journal of ethnopharmacology 2025 May 12;347:119792
Baicalin prevents experimental autoimmune uveitis by promoting macrophage polarization balance through inhibiting the HIF-1α signaling pathway.
Liu B, Peng Y, Wang C, Wei H, Xu S, Liu Y, Yin X, Bi H, Guo D
Scientific reports 2025 May 12;15(1):16424
Scientific reports 2025 May 12;15(1):16424
CKIP-1 inhibits M2 macrophage polarization to suppress the progression of gastric cancer by inactivating JAK/STAT3 signaling.
Xu X, Xu Z, Cai Y, Chen X, Huang C
Cell biochemistry and biophysics 2025 Mar;83(1):1289-1298
Cell biochemistry and biophysics 2025 Mar;83(1):1289-1298
DANCR knockdown alleviates neuroinflammation and functional recovery after spinal cord injury via regulating the ACTN4 / STAT3 axis.
Xia B, Yu C, Liu J, Lin J, Lyu J, Wang X, Zhu L
Archives of biochemistry and biophysics 2025 Mar;765:110293
Archives of biochemistry and biophysics 2025 Mar;765:110293
ISRIB facilitates post-spinal cord injury recovery through attenuation of neuronal apoptosis and modulation of neuroinflammation.
Li Q, Zhang C, Qi E, Wu M, Sun H, Zhang T, Jiang Y, Li H, Jiang R, Li C, Zhao H, Zhou H, Feng S
Journal of orthopaedic translation 2025 Mar;51:119-131
Journal of orthopaedic translation 2025 Mar;51:119-131
Suppression of Sepsis Cytokine Storm by Escherichia Coli Cell Wall-Derived Carbon Dots.
Li Y, Huang X, Qiao Q, Li Y, Han X, Chen C, Chen Y, Guo S, Zhang Y, Gao W, Liu H, Sun T
Advanced materials (Deerfield Beach, Fla.) 2025 Mar;37(12):e2414237
Advanced materials (Deerfield Beach, Fla.) 2025 Mar;37(12):e2414237
Early intervention with pericyte Fli-1 post-TBI attenuates hippocampal BBB disruption and subsequent neuroinflammation with neurological deficits.
Li J, Du M, Dong G, Hu D, Zhang H, Yu Z, Lu Y, Yang Y
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167671
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167671
Screening effective-component compatibility from Jinshui Chenfei formula for silicosis treatment by serum-pharmacochemistry and feedback system control.
Liu X, Zhao P, Wang L, Wu J, He W, Wei Y, Chen H, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156419
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156419
Exploring the active components and potential mechanisms of Zhimu-Huangbai herb-pair in the treatment of depression.
Lei X, Zhao D, Chen T, Li Q, Xue A, Hu Z, Jia F, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156365
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156365
Adropin-Driven Browning: Targeting M2 Macrophages to Combat PCOS.
Zhang S, Li J, Lv X, Pan G, Liu Q, Zheng L, Xu L
International immunopharmacology 2025 Mar 6;149:114273
International immunopharmacology 2025 Mar 6;149:114273
Indole-3-Propionic Acid Attenuates Neuroinflammation and Cognitive Deficits by Inhibiting the RAGE-JAK2-STAT3 Signaling Pathway.
Hao Z, Ji R, Su Y, Wang H, Yang W, Zhang S, Liu Y, Ma S, Guan F, Cui Y
Journal of agricultural and food chemistry 2025 Mar 5;73(9):5208-5222
Journal of agricultural and food chemistry 2025 Mar 5;73(9):5208-5222
Luteolin modulates liver macrophage subtype polarization and play protective role in sepsis induced acute hepatic injury.
Deng L, Yu Q, Kuang G, Wang L, Fan J, Ye L
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Mar 28;74(1):59
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Mar 28;74(1):59
Mechanism of action of Danlou tablets affecting MAFLD via KEAP1-mediated oxeiptosis.
Zhu J, Song N, Wang J, Wang Q, Cao Y, Zhang M, Sun X, Jia L
Journal of ethnopharmacology 2025 Mar 26;344:119521
Journal of ethnopharmacology 2025 Mar 26;344:119521
Berberine Exerts Neuroprotective Effects in Alzheimer's Disease by Switching Microglia M1/M2 Polarization Through PI3K-AKT Signaling.
Hu Y, Zhang P, Wang X
Physiological research 2025 Mar 24;74(1):129-140
Physiological research 2025 Mar 24;74(1):129-140
Intranasal delivery of engineered extracellular vesicles promotes neurofunctional recovery in traumatic brain injury.
Li P, Sun S, Zhu X, Liu X, Yin R, Chen Y, Chang J, Ye L, Gao J, Zhao X, Xu H, Wang Y, Zuo W, Sun Z, Wang S, Zhang X, Wei J, Zhao RC, Han Q
Journal of nanobiotechnology 2025 Mar 21;23(1):229
Journal of nanobiotechnology 2025 Mar 21;23(1):229
Activated NETosis of bone marrow neutrophils up-regulates macrophage osteoclastogenesis via cGAS-STING/AKT2 pathway to promote osteoporosis.
Guo Y, Zhou H, Wang Y, Gu Y
Experimental cell research 2025 Mar 15;446(2):114477
Experimental cell research 2025 Mar 15;446(2):114477
Corilagin enhances wound healing by modulating the macrophage phenotype in diabetic mice.
Li Y, Yu S, Zeng J, Zhou S, Cui X, Zhou J, Zhang P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 15;39(5):e70439
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 15;39(5):e70439
LXRα agonists ameliorates acute rejection after liver transplantation via ABCA1/MAPK and PI3K/AKT/mTOR signaling axis in macrophages.
Qin X, Hu D, Li Q, Zhang S, Qin Z, Wang L, Liao R, Wu Z, Liu Y
Molecular medicine (Cambridge, Mass.) 2025 Mar 14;31(1):99
Molecular medicine (Cambridge, Mass.) 2025 Mar 14;31(1):99
Brown adipose tissue transplantation ameliorates hindlimb ischemic damage in diabetic mice.
Lu T, Liu A, Li C, Li Y, Yang B, Liu Q, Jiang H
Scientific reports 2025 Mar 14;15(1):8820
Scientific reports 2025 Mar 14;15(1):8820
GHSR gene knockout alleviates the liver pathological response in Echinococcus granulosus infection by reducing parasite survival.
Zhu J, Zhou T, Chen G, Gao H, Chen X, Tuohetali A, Song Y, Pang D, Aimulajiang K
Veterinary research 2025 Mar 11;56(1):55
Veterinary research 2025 Mar 11;56(1):55
Static Topographical Cue Combined with Dynamic Fluid Stimulation Enhances the Macrophage Extracellular Vesicle Yield and Therapeutic Potential for Bone Defects.
Huang H, Xiao L, Fang L, Lei M, Liu Z, Gao S, Lei Q, Lei J, Wei R, Lei Y, Xue L, Geng Z, Cai L, Yan F
ACS nano 2025 Mar 11;19(9):8667-8691
ACS nano 2025 Mar 11;19(9):8667-8691
Folate-targeted nanoparticles for glutamine metabolism inhibition enhance anti-tumor immunity and suppress tumor growth in ovarian cancer.
Chen S, Jiang Y, Zheng J, Li P, Liu M, Zhu Y, Zhu S, Chang S
Journal of controlled release : official journal of the Controlled Release Society 2025 Mar 10;379:89-104
Journal of controlled release : official journal of the Controlled Release Society 2025 Mar 10;379:89-104
LCN2 Regulates Microglia Polarization Through the p38MAPK-PGC-1α-PPARγ Pathway to Alleviate Traumatic Brain Injury.
Du H, Lai J, Lin B, Pan J, Zhou Y, Feng Y
Cell biochemistry and biophysics 2025 Jun;83(2):2301-2311
Cell biochemistry and biophysics 2025 Jun;83(2):2301-2311
Myelination Trajectory and Microglial Dynamics Following Repeated Sevoflurane Exposure in Developing Brain.
Che J, Wu Y, Dong J, Jiang X, Yang L, Chen Y, Zhang J
Glia 2025 Jun;73(6):1221-1240
Glia 2025 Jun;73(6):1221-1240
Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Through the Promotion of Type 2 Macrophage Polarization.
Zhu X, Wang Y, Sun Z, Cheng W, Chen K, Gao X, Meng J, Li S, Zheng W, Wang Y, Yin X, Zhou X
Stem cells and development 2025 Jun;34(11-12):258-270
Stem cells and development 2025 Jun;34(11-12):258-270
Injectable bioresponsive bone adhesive hydrogels inhibit NLRP3 inflammasome on demand to accelerate diabetic fracture healing.
Xing X, Gong Z, Chen C, Lin Y, Liu P, Xiao T, Yu H, Li Y, Lin Y, Tan G, Ning C, Wu Z, Wang L, Zhou L
Biomaterials 2025 Jun;317:123059
Biomaterials 2025 Jun;317:123059
miR-301a-5p regulated IKKβ/NF-κB axis and macrophage polarization to accelerate skin wound healing.
Li Y, Fu Z, Deng C, Qian J, Wang Z, Lu Y, Zhang S, Liu G, Wen J, Chen Y, Jiang J, Liu X, Zheng X, Shen X, Su W, Yang M, Tang J, Wang Y, Meng B, Yang X
International journal of biological macromolecules 2025 Jun;311(Pt 4):143995
International journal of biological macromolecules 2025 Jun;311(Pt 4):143995
Gallic acid promotes M2 macrophage polarization through mitochondrial oxidative phosphorylation in periodontitis.
Zhang R, Yang W, Li K, Zhang X, Liu J, Ai L
Archives of oral biology 2025 Jun;174:106237
Archives of oral biology 2025 Jun;174:106237
TGF-β1 induces autophagy and mediates the effect on macrophages differentiation in primary liver cancer.
Liu C, Li M, Liu L, Xu Q, Zheng L, Wu C, Ren J, Zhang T, Wang H, Lin Z
International immunopharmacology 2025 Jun 5;157:114799
International immunopharmacology 2025 Jun 5;157:114799
Malvidin Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Modulating JAK2/STAT3 Signaling to Inhibit Macrophage M1 Polarization and Oxidative Stress.
Mao X, Liu X, Wei C, Tang H, Yin F, Zhang Z, Yu K, Liu H, Wang C, Le A
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13488-13501
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13488-13501
N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia/macrophage via the AMPK-PGC1α-PPARγ pathway to promote recovery in mice with spinal cord injury.
Ying W, Weng W, Wang P, Pan C, Qiu J, Huang Q, Zhan G, Chen X
Journal of neuroinflammation 2025 Jun 27;22(1):167
Journal of neuroinflammation 2025 Jun 27;22(1):167
GDF15 suppresses abdominal aortic aneurysm by upregulating AREG expression to adjust macrophage polarization.
Wu W, Tang W, Liang W, Li Q, Qi X, Gao R, Zhou P, Chen G, Xiong J, Gu X, Ding P, Yu M, Yang C, Wen S
International immunopharmacology 2025 Jun 26;159:114899
International immunopharmacology 2025 Jun 26;159:114899
ISCU-p53 axis orchestrates macrophage polarization to dictate immunotherapy response in esophageal squamous cell carcinoma.
Luo J, Zhang X, Liang Z, Zhuang W, Jiang M, Ma M, Peng S, Huang S, Qiao G, Chen Q
Cell death & disease 2025 Jun 20;16(1):462
Cell death & disease 2025 Jun 20;16(1):462
Human Amniotic Fluid-Derived Exosomes Alleviate Neuropathic Pain by Inducing an Anti-Inflammatory Transition in Microglia.
Li Q, Dai H, Zhang S, Li P, Peng L, Chen Y, Guo Q, Yang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70664
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70664
Tailored "Three-stage booster" nano-extinguisher for synergistic treatment of severe acute pancreatitis by rectifying mitochondrial dysfunction and inhibiting pancreatic autodigestion.
Yan J, Liu H, Xu Y, Sun X, Meng X, Wei S, Li Z, Jin X, Liu J, Wang X, Cui P, He Z
Acta biomaterialia 2025 Jun 15;200:569-590
Acta biomaterialia 2025 Jun 15;200:569-590
Sirt5-mediated polarization and metabolic reprogramming of macrophage sustain brain function following ischemic stroke.
Zhang L, Lv T, Hou P, Jin Y, Jia F
Brain research 2025 Jun 15;1857:149613
Brain research 2025 Jun 15;1857:149613
Fate reversal: Exosome-driven macrophage rejuvenation and bacterial-responsive drug release for infection immunotherapy in diabetes.
Zou J, Cui W, Deng N, Li C, Yang W, Ye X, Yao F, Zhang T, Xiao J, Ma C, Wu L, Dong D, Chen J, Guo C, Liu A, Wu H
Journal of controlled release : official journal of the Controlled Release Society 2025 Jun 10;382:113730
Journal of controlled release : official journal of the Controlled Release Society 2025 Jun 10;382:113730
Secretome enriched with small extracellular vesicles derived from human gingiva-derived mesenchymal stem cells enhances rat tongue muscle regeneration.
Zhang Q, He P, Shi S, Xu Q, Granquist EJ, Winkelstein BA, Shanti RM, Le AD
Journal of nanobiotechnology 2025 Jun 10;23(1):434
Journal of nanobiotechnology 2025 Jun 10;23(1):434
GDF11 Regulates M1 and M2 Polarization of BV2 Microglial Cells via p38 MAPK Signaling Pathway.
Zhao X, Qin R, Li G, Lv G, Zhao D, Kong L, Qi M, Li P
Molecular neurobiology 2025 Jul;62(7):9290-9305
Molecular neurobiology 2025 Jul;62(7):9290-9305
Immune-modulated adhesive hydrogel for enhancing osteochondral graft adhesion and cartilage repair.
Zhou J, Ji X, Xue Y, Yang W, Zhong G, Zhou Z, Chen X, Lei Z, Lu T, Zhang Y, Liu J, Ma L
Bioactive materials 2025 Jul;49:23-38
Bioactive materials 2025 Jul;49:23-38
Methacrylated sericin/methacrylated hyaluronic acid composite microneedles with exosomes for diabetic wound healing.
Xu X, Shen Y, Wu J, Hong F, Xia H, Chen X, Lin G, Liu L, Xu RA
International journal of biological macromolecules 2025 Jul;318(Pt 1):144957
International journal of biological macromolecules 2025 Jul;318(Pt 1):144957
Bacillus paralicheniformis-mediated gut microbiota promotes M2 macrophage polarization by inhibiting P38 MAPK signaling to alleviate necrotizing enterocolitis and apoptosis in mice.
Yang S, Pan H, Wang T, Zhou X, Fan L, Xiao H, Zhou Z, Xiao Y, Shi D
Microbiological research 2025 Jul;296:128136
Microbiological research 2025 Jul;296:128136
Optimally Aligned Nerve Scaffolds with Sustained Astaxanthin Release Improve the Inflammatory Microenvironment through Mitophagy Activation.
Jin X, Liu S, Fang J, Chen F, Xu B, Nan L, Zhao S, Wu Z, Guan Z, Tao K, Liu J
Small (Weinheim an der Bergstrasse, Germany) 2025 Jul;21(26):e2502939
Small (Weinheim an der Bergstrasse, Germany) 2025 Jul;21(26):e2502939
p16INK4a downregulation alleviates temporomandibular joint osteoarthritis combined with type 2 diabetes by driving M2 polarization.
Cai J, Zhang L, Du Q, Wang M, Ma X, Chen Y, Wang Y, Yuan H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jul;188:118172
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jul;188:118172
DPSCs modulate synovial macrophage polarization and efferocytosis via PINK1/Parkin-dependent mitophagy.
Ma J, Wang X, Sun D, Chen J, Zhou L, Zou K, Ni X, Jin H, Lin J
Stem cell research & therapy 2025 Jul 9;16(1):356
Stem cell research & therapy 2025 Jul 9;16(1):356
Macrophage EP4 Deficiency Drives Atherosclerosis Progression via CD36-Mediated Lipid Uptake and M1 Polarization.
Tang X, Chen Q, Guo M, Wen Y, Jia C, Bu Y, Wang T, Zhang Y, Tang W
Cells 2025 Jul 4;14(13)
Cells 2025 Jul 4;14(13)
Rhein Inhibits Microglia-Mediated Neuroinflammation and Neuronal Damage of Alzheimer's Disease via Regulating the Glutamine-Aspartate-Arginine-NO Metabolic Pathway.
Chi B, Zhang Z, Zhang Z, Zhang H, Tian M, Wang Y, Gao X
International journal of molecular sciences 2025 Jul 3;26(13)
International journal of molecular sciences 2025 Jul 3;26(13)
Salvianolic Acid B Attenuates Liver Fibrosis via Suppression of Glycolysis-Dependent m1 Macrophage Polarization.
Song H, Li ZW, Xu W, Tan Y, Kuang M, Pei G, Wang ZQ
Current issues in molecular biology 2025 Jul 29;47(8)
Current issues in molecular biology 2025 Jul 29;47(8)
Targeted Inhibition of Aldose Reductase by Isoliquiritigenin Suppresses Fatty Acid Synthesis to Inhibit Macrophage M2 Polarization and Alleviate Pulmonary Fibrosis.
Mei X, Zhang Q, Shao W, Zheng J, Zhao P, Li J
Journal of agricultural and food chemistry 2025 Jul 23;73(29):18252-18267
Journal of agricultural and food chemistry 2025 Jul 23;73(29):18252-18267
Pan-cancer human brain metastases atlas at single-cell resolution.
Xing X, Zhong J, Biermann J, Duan H, Zhang X, Shi Y, Gao Y, He K, Zhai D, Luo F, Lai Y, Xiao F, Wang W, Wang M, Xu J, Liu H, Tang J, Chu L, Chen T, D'Souza EK, Caprio L, Ebel L, Biswas D, Cottarelli A, Mou Y, Izar B, Zhang N, Bai F
Cancer cell 2025 Jul 14;43(7):1242-1260.e9
Cancer cell 2025 Jul 14;43(7):1242-1260.e9
S100a4(+) alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism.
Huang H, Yang Y, Zhang Q, Yang Y, Xiong Z, Mao S, Song T, Wang Y, Liu Z, Bu H, Zhang L, Zhang L
eLife 2025 Jul 14;13
eLife 2025 Jul 14;13
MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization.
Zhang J, Zhan Y, Deng Z, Chen S, Yang R, Zhang Y, Fu H, Huang Q, Wu J, Gu Y, Xie J
Respiratory research 2025 Jul 10;26(1):238
Respiratory research 2025 Jul 10;26(1):238
Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzheimer's disease by activating the Wnt/β-catenin signaling.
Zhu L, Zhou T, Wu L, Zhu X, Chen L, Zhang M, Zhou J, Wang F
Scientific reports 2025 Jul 10;15(1):24968
Scientific reports 2025 Jul 10;15(1):24968
ROS Responsive Cerium Oxide Biomimetic Nanoparticles Alleviates Calcium Oxalate Crystals Induced Kidney Injury via Suppressing Oxidative Stress and M1 Macrophage Polarization.
He Y, Peng E, Ba X, Wu J, Deng W, Huang Q, Tong Y, Shang H, Zhong Z, Liu X, Zhang Y, Ye T, Yang X, Wang K, Xie Y, Jiang K, Xia D, Chen Z, Tang K
Small (Weinheim an der Bergstrasse, Germany) 2025 Jan;21(3):e2405417
Small (Weinheim an der Bergstrasse, Germany) 2025 Jan;21(3):e2405417
Inhibition of PKM2 by shikonin impedes TGF-β1 expression by repressing histone lactylation to alleviate renal fibrosis.
Xiang T, Wang X, Huang S, Zhou K, Fei S, Zhou B, Yue K, Li Q, Xue S, Dai Y, Zhang J, Ni H, Sun C, Huang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156324
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156324
Pimpinellin mitigates DSS-induced ulcerative colitis in mice by reducing inflammation and regulating gut microbiota.
Lv B, Hou L, Zhang H, Hao C, Song Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156308
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156308
Ginsenoside RK3 inhibits glioblastoma by modulating macrophage M2 polarization via the PPARG/CCL2 axis.
Zhang H, Hu J, Zhao X, Zheng B, Han Y, Luo G, Dou D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156271
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156271
Matrix Metalloproteinase-Responsive Controlled Release of Self-Assembly Nanoparticles Accelerates Heart Valve Regeneration In Situ by Orchestrating Immunomodulation.
Chen X, Wu Y, Song P, Feng L, Zhou Y, Shi J, Dong N, Qiao W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2403351
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2403351
Viscoelastic Hydrogel Modulates Phenotype of Macrophage-Derived Multinucleated Cells and Macrophage Differentiation in Foreign Body Reactions.
Fang JY, Yang Z, Hu W, Hoang BX, Han B
Journal of biomedical materials research. Part A 2025 Jan;113(1):e37814
Journal of biomedical materials research. Part A 2025 Jan;113(1):e37814
Zuojin Wan Suppresses the Progression of Colorectal Cancer by Inhibiting M2 Tumor-Associated Macrophages Through JAK2/STAT3 Signaling Pathway and In Vivo and In Vitro.
Nong F, Xing S, Cheng W, Deng S
Integrative cancer therapies 2025 Jan-Dec;24:15347354251375951
Integrative cancer therapies 2025 Jan-Dec;24:15347354251375951
Inhibition of macrophage polarization and pyroptosis in collagen-induced arthritis through MSC-exo and ginsenoside Rh2.
Zhou Z, Wu S, Li Y, Shao P, Jiang J
Arthritis research & therapy 2025 Jan 9;27(1):6
Arthritis research & therapy 2025 Jan 9;27(1):6
A Disintegrin and Metalloproteinase 17 Disrupts Bovine Macrophage MER Proto-Oncogene Tyrosine Kinase Integrity to Impede Apoptotic Cell Clearance and Promote Inflammation in Clinical Mastitis.
Wang J, Li M, Zhao B, Chang R, Wu W, Zhang H, Usman M, Loor JJ, Xu C
Journal of agricultural and food chemistry 2025 Jan 8;73(1):549-561
Journal of agricultural and food chemistry 2025 Jan 8;73(1):549-561
SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia.
Xu Z, Zhu M, Xie H, Zhu J, Zheng H, Liu X, Zhang Y, Liu J
Scientific reports 2025 Jan 8;15(1):1283
Scientific reports 2025 Jan 8;15(1):1283
ANGPTL4 induces Kupffer cell M2 polarization to mitigate acute rejection in liver transplantation.
Huang W, Jiang L, Jiang Y, Li S, Liu W, Zong K, Peng D, Wu Z, Huang Z
Scientific reports 2025 Jan 6;15(1):986
Scientific reports 2025 Jan 6;15(1):986
Natural phenol carbamates: Selective BuChE/FAAH dual inhibitors show neuroprotection in an Alzheimer's disease mouse model.
Rong K, Li Z, Wu X, Gao S, Zhao J, Yang J, Jiang X, Zhang J, Tang W
European journal of medicinal chemistry 2025 Jan 5;281:117003
European journal of medicinal chemistry 2025 Jan 5;281:117003
Lemon-derived nanoparticle-functionalized hydrogels regulate macrophage reprogramming to promote diabetic wound healing.
Jin E, Yang Y, Cong S, Chen D, Chen R, Zhang J, Hu Y, Chen W
Journal of nanobiotechnology 2025 Jan 31;23(1):68
Journal of nanobiotechnology 2025 Jan 31;23(1):68
Total alkaloids in Fritillaria cirrhosa D. Don alleviate OVA-induced allergic asthma by inhibiting M2 macrophage polarization.
Wang Y, Peng M, Yang X, Tu L, Liu J, Yang Y, Li R, Tang X, Hu Y, Zhang G, Zhao Q, Lu Q
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118935
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118935
Multi-platform analysis revealed the substance basis and mechanism of Wei-Tong-Xin in ameliorating ENS dysfunction for dyspepsia treatment.
Zhang X, Wang S, Xie J, Wang J, Gu Y, Wu B, Zhang Y, Yan T, Jia Y
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118875
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118875
Nitric Oxide-Releasing Mesoporous Hollow Cerium Oxide Nanozyme-Based Hydrogel Synergizes with Neural Stem Cell for Spinal Cord Injury Repair.
Liu D, Niu R, Wang S, Shao L, Yang X, Liu X, Ma X, Zhu Z, Zhang J, Shi B, Ni H, Du X
ACS nano 2025 Jan 21;19(2):2591-2614
ACS nano 2025 Jan 21;19(2):2591-2614
Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression.
Ye Z, Yi J, Jiang X, Shi W, Xu H, Cao H, Qin L, Liu L, Wang T, Ma Z, Jiao Z
Journal of experimental & clinical cancer research : CR 2025 Jan 2;44(1):2
Journal of experimental & clinical cancer research : CR 2025 Jan 2;44(1):2
Zinc-induced photocrosslinked konjac glucomannan/glycyrrhizic acid hydrogel promotes skin wound healing in diabetic mice through immune regulation.
Li J, Wu D, Su Z, Guo J, Cui L, Su H, Chen Y, Yu B
Carbohydrate polymers 2025 Jan 15;348(Pt A):122780
Carbohydrate polymers 2025 Jan 15;348(Pt A):122780
Luteolin modulates macrophage phenotypic switching via the AMPK-PPARγ pathway to alleviate ulcerative colitis in mice.
Yang S, Duan H, Zeng J, Yan Z, Niu T, Ma X, Zhang Y, Hu J, Zhang L, Zhao X
Journal of ethnopharmacology 2025 Jan 13;339:119157
Journal of ethnopharmacology 2025 Jan 13;339:119157
Hepatoma cell-derived exosomal SNORD52 mediates M2 macrophage polarization by activating the JAK2/STAT6 pathway.
Zhang Y, Li B, Gu W, Fan L, Wang X, Xu M, Zhu M, Jin C
Discover oncology 2025 Jan 13;16(1):36
Discover oncology 2025 Jan 13;16(1):36
Dentin tubules as a long-term sustained release carrier to accelerate bone repair by loading FTY720.
Xie J, Huang H, Xu S, Zhou K, Chen X, Fang J, Zhao F
Journal of controlled release : official journal of the Controlled Release Society 2025 Jan 10;377:446-457
Journal of controlled release : official journal of the Controlled Release Society 2025 Jan 10;377:446-457
A reactive oxygen species-responsive hydrogel loaded with Apelin-13 promotes the repair of spinal cord injury by regulating macrophage M1/M2 polarization and neuroinflammation.
Li Z, Zhao Q, Zhou J, Li Y, Zheng Y, Chen L
Journal of nanobiotechnology 2025 Jan 10;23(1):12
Journal of nanobiotechnology 2025 Jan 10;23(1):12
Hyperactivity of the IL-33-ILC2s-IL-13-M-MDSCs axis promotes cervical cancer progression.
Wang B, Zhu Y, Zhang Y, Ru Z, Chen L, Zhang M, Wu Y, Ding J, Chen Z
International immunopharmacology 2025 Jan 10;144:113693
International immunopharmacology 2025 Jan 10;144:113693
N 6-Methyladenosine Demethylase FTO Controls Macrophage Homeostasis in Diabetic Vasculopathy.
Feng S, Zhang Q, Liu Q, Huang C, Zhang H, Wang F, Zhu Y, Jian Q, Chen X, Jiang Q, Yan B
Diabetes 2025 Jan 1;74(1):82-95
Diabetes 2025 Jan 1;74(1):82-95
Macrophage metabolic reprogramming ameliorates diabetes-induced microvascular dysfunction.
Zhang QY, Zhang HY, Feng SG, Yao MD, Ding JJ, Li XM, Ye R, Liu Q, Yao J, Yan B
Redox biology 2025 Feb;79:103449
Redox biology 2025 Feb;79:103449
β-Catenin mediated TAM phenotype promotes pancreatic cancer metastasis via the OSM/STAT3/LOXL2 axis.
Zhang Y, Zhu X, Chen L, Gao T, Chen G, Zhu J, Wang G, Zuo D
Neoplasia (New York, N.Y.) 2025 Feb;60:101096
Neoplasia (New York, N.Y.) 2025 Feb;60:101096
RBPJ Knockdown Promotes M2 Macrophage Polarization Through Mitochondrial ROS-mediated Notch1-Jagged1-Hes1 Signaling Pathway in Uveitis.
Qu R, Peng Y, Xu S, Zhou M, Yin X, Liu B, Bi H, Guo D
Inflammation 2025 Feb;48(1):133-150
Inflammation 2025 Feb;48(1):133-150
Intra-cisterna-magna bevacizumab injection (ICM-BI) reproduces pathological alterations of cerebral small vessel diseases.
Kang X, Su X, Li T, Wang S, Huang H, Liu Y, Li C, Deng X, Hu M, Lu T, Wei L, Cai W, Lu Z
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2025 Feb;45(2):244-258
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2025 Feb;45(2):244-258
Astragaloside IV Alleviates Acute Hepatic Injury by Regulating Macrophage Polarization and Pyroptosis via Activation of the AMPK/SIRT1 Signaling Pathway.
Kuang G, Zhao Y, Wang L, Wen T, Liu P, Ma B, Peng Q, Xu F, Ye L, Fan J
Phytotherapy research : PTR 2025 Feb;39(2):733-746
Phytotherapy research : PTR 2025 Feb;39(2):733-746
Nasal mucosal mesenchymal stem cells promote repair of sciatic nerve injury in rats by modulating the inflammatory microenvironment.
Tang Y, Li Y, Yang W, Tao Z, Shi W, Yu M, Xu B, Lu X
Neuroscience letters 2025 Feb 6;848:138112
Neuroscience letters 2025 Feb 6;848:138112
Citrulline Plus Arginine Induces an Angiogenic Response and Increases Permeability in Retinal Endothelial Cells via Nitric Oxide Production.
Warden C, Zubieta D, Brantley MA Jr
International journal of molecular sciences 2025 Feb 27;26(5)
International journal of molecular sciences 2025 Feb 27;26(5)
Dapagliflozin alleviated seizures and cognition impairment in pilocarpine induced status epilepticus via suppressing microglia-mediated neuroinflammation and oxidative stress.
Liu Y, Yu Y, Chen C, Wu X, Zheng Q, Zhang X, Ye L, Zhang C, Feng Z
International immunopharmacology 2025 Feb 20;148:114117
International immunopharmacology 2025 Feb 20;148:114117
MiR-186-5p carried by M2 macrophage-derived exosomes downregulates TRPP2 expression in airway smooth muscle to alleviate asthma progression.
Wang Z, Ren Y, Li Y, Zhang Y, Bai S, Hou W, Zhang W, Yao Y, Zhao H, Wang M, Luo Y, Pang G, Du J
International immunopharmacology 2025 Feb 20;148:114107
International immunopharmacology 2025 Feb 20;148:114107
Circular RNA APP contributes to Alzheimer's disease pathogenesis by modulating microglial polarization via miR-1906/CLIC1 axis.
Wu DP, Wei YS, Hou LX, Du YX, Yan QQ, Liu LL, Zhao YD, Yan RY, Yu C, Zhong ZG, Huang JL
Alzheimer's research & therapy 2025 Feb 14;17(1):44
Alzheimer's research & therapy 2025 Feb 14;17(1):44
Eu-Doped TiO(2) Coatings via One-Step In Situ Preparation Enhance Macrophage Polarization and Osseointegration of Implants.
Zhang B, Qu H, Zhang Z, Wang X, Dou Z, Li X, Cao R, Zhang K, Zhang J, Zhang Q
ACS applied materials & interfaces 2025 Feb 12;17(6):8886-8900
ACS applied materials & interfaces 2025 Feb 12;17(6):8886-8900
Intelligent sequential degradation hydrogels by releasing bimetal-phenolic for enhanced diabetic wound healing.
Zhang Y, Tang Z, Chen L, Yang M, Zeng Y, Bai X, Zhang B, Zhou J, Zhang W, Tang S
Journal of controlled release : official journal of the Controlled Release Society 2025 Feb 10;378:961-981
Journal of controlled release : official journal of the Controlled Release Society 2025 Feb 10;378:961-981
Indirubin regulates M1/M2 polarization and inhibits ferroptosis in dextran sulfate sodium induced colitis and in cultured THP-1 cells.
Huang YX, Zhang JR, Fu SH, Liu Z, Zhong HJ, Zhong QY, Luo YD, Hu YJ, Zhu HP, Wen B, Chen S
Pharmaceutical biology 2025 Dec;63(1):698-715
Pharmaceutical biology 2025 Dec;63(1):698-715
Nano MgO loaded thermosensitive HPCH@HA hydrogel accelerates in situ bone repair through osteoimmunomodulation while enhancing angiogenesis and osteogenesis.
Ni F, Chang L, Peng Y, Li D, Wu D, Li K, Zhang X, Jiang X, Shao Z, Chen Y, Wang H
Bioactive materials 2025 Dec;54:248-272
Bioactive materials 2025 Dec;54:248-272
Exosome-mediated perturbation of the immune-bone metabolism axis: a mechanistic investigation into bone loss in a simulated microgravity environment.
Yang F, Chen C, Yang C, Chen R, Liu Z, Wen L, Xiao H, Zhou L, Geng B, Xia Y
Artificial cells, nanomedicine, and biotechnology 2025 Dec;53(1):494-513
Artificial cells, nanomedicine, and biotechnology 2025 Dec;53(1):494-513
Genetic Ablation of miR-146a Induces Abdominal Aortic Aneurysm Formation by Intensifying Inflammatory M1-Like Macrophages Polarization and Vascular Smooth Muscle Cell Phenotypic Switching.
Zhong L, Sun Y, Chen G, Wang J, Yang Z, Lu W, Xiao X, Song H, Xiong J, Lin B, Wang K, Yang S, Bin J, Jiang X
Arteriosclerosis, thrombosis, and vascular biology 2025 Dec;45(12):2210-2225
Arteriosclerosis, thrombosis, and vascular biology 2025 Dec;45(12):2210-2225
PUFAs-enriched oil bodies as natural anti-osteoarthritis drug delivery platforms.
Shen L, Li J, Zhang X, Wu Q, Qi H, Lou C, Chen Z, Wu L, Chen X, Qiu F, Chen M, Li X, Wang Z, Zhu Y, He D, Ji J, Shu G
Materials today. Bio 2025 Dec;35:102606
Materials today. Bio 2025 Dec;35:102606
Whitlockite-loaded silk fibroin/polyvinyl alcohol hydrogel composited with porous tantalum scaffold enhances bone regeneration and immunomodulation via the TGF-β/NRROS signaling pathway.
Ge B, Jiao H, Xu J, Wu D, Xie Q, Zheng G, Cao F, Yin G, Zhao D, Li J
Materials today. Bio 2025 Dec;35:102532
Materials today. Bio 2025 Dec;35:102532
Silicified strontium-curcumin chelated nanospheres mitigate inflammatory vicious cycles to accelerate diabetic wound healing.
Zhao Z, Ding Y, Gao G, Zhang Y, Zhang Z, Zhou M, Yuan Y
Materials today. Bio 2025 Dec;35:102407
Materials today. Bio 2025 Dec;35:102407
A dual-drug sequential delivery hydrogel for programmatic microglia/macrophage polarization and function recovery in spinal cord injury.
Li Y, Liang Y, He C, Yao R, Jian K, Shi L
Materials today. Bio 2025 Dec;35:102365
Materials today. Bio 2025 Dec;35:102365
Deoxycholic Acid and Lipoteichoic Acid cooperatively drive macrophage M2/M1 polarization via TGR5/STAT3 and TLR2/NF-κB to fuel HCC progression in obesity.
Wu J, Zheng W, Ding XZ, Jin QP, Ding MX
Metabolism open 2025 Dec;28:100420
Metabolism open 2025 Dec;28:100420
MicroRNA-3473b regulates corticosterone-induced microglial polarization and inflammation through TREM2.
Shi J, Ma C, Liu Y, Yang C, Wu J, Wang X
Journal of pharmacological sciences 2025 Dec;159(4):209-218
Journal of pharmacological sciences 2025 Dec;159(4):209-218
Injury-induced Clusterin(+) cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages.
Fan L, Tang Q, Wang Y, Sun H, Li G, Yang Y, Zhu H, Liu Z, Wang H, Wang H, Jing Q, Antos CL, Xiao H, Guan R, Pei G, Ginhoux F, Zhou Z, Zeng A
Cell stem cell 2025 Dec 4;32(12):1849-1868.e15
Cell stem cell 2025 Dec 4;32(12):1849-1868.e15
Microglia-specific interleukin-4 delivery by engineered extracellular vesicles restores inner blood-retinal barrier in diabetic retinopathy via GAS6-MERTK pathway.
Fan Y, Ge P, Wang X, Xu J, Wang J, Li H, Gu Q, Xie H, Lin Y, Lu Y, Wang C, Xie P, Hu Z
Journal of nanobiotechnology 2025 Dec 29;24(1):101
Journal of nanobiotechnology 2025 Dec 29;24(1):101
MSC administration resolves experimental acute gout increasing specialized pro-resolving mediators synthesis through a super-induction of prostaglandin E(2).
Bermejo-Álvarez I, Vázquez C, Irigaray-Moreno A, Quevedo-Romero I, Mediero A, Herrero-Beaumont G, Largo R
Stem cell research & therapy 2025 Dec 25;17(1):53
Stem cell research & therapy 2025 Dec 25;17(1):53
Enhanced therapeutic efficacy of repeated bone marrow-derived MSC administration in a murine model of pulmonary fibrosis.
Zhou Z, Ding J, Han S, Duan Y, Chao J, Huang J
Stem cell research & therapy 2025 Dec 23;17(1):48
Stem cell research & therapy 2025 Dec 23;17(1):48
Ectomesenchymal Stem Cell Transplantation Induces Microglial Polarization and Anti-inflammatory IL-10 Secretion via NF-κB and MAPK Pathways to Mitigate Brain Injury Post-cerebral Hemorrhage.
Li Y, Yang W, Tang Y, Du S, Ye Y, Xu B, Shi W, Zhao X, Lu X
Neurochemical research 2025 Dec 20;51(1):20
Neurochemical research 2025 Dec 20;51(1):20
Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling.
Ning P, Wu J, Long Q, Zheng Y, Gan J, Hu X, Song S, Li X, Jiang M, Ye H, Yu W, He Y, Zheng Y, Gao Z
Inflammation 2025 Dec 20;49(1):11
Inflammation 2025 Dec 20;49(1):11
Genistein ameliorates non-alcoholic fatty liver disease in mice by modulating gut microbiota and hepatic macrophage polarization.
Fang S, Han H, Wang R, Li S, Yang R, Mehmood S, Jia Q
Scientific reports 2025 Dec 18;15(1):44085
Scientific reports 2025 Dec 18;15(1):44085
Astragaloside IV improves cognitive impairment in diabetes by inhibiting calpain-1/NLRP3 mediated microglial activation.
Wang X, Jiang H, Wang H, Zhao C, Ba X
International immunopharmacology 2025 Dec 10;167:115682
International immunopharmacology 2025 Dec 10;167:115682
Calcineurin/NFAT1/Smad2 signaling regulates microglial autophagy that contributes to neuroinflammation and cognitive deficit in mice with sepsis-associated encephalopathy.
Ding R, Hu N, Zhang X, Jiang F, Feng Y, Li Z, Tang S, Li W, Shi H, Si Y
Free radical biology & medicine 2025 Dec 1;240:15-28
Free radical biology & medicine 2025 Dec 1;240:15-28
Xuebijing inhibits alveolar macrophage M1 polarization by regulating ROS-mediated NLRP3 inflammasome signaling.
Chen X, Zhang F, Zhou Z, Jiang D, Wen L
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):789-800
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):789-800
Sequential simulation of regeneration-specific microenvironments using scaffolds loaded with nanoplatelet vesicles enhances bone regeneration.
Li W, Shen Q, Tong T, Tian H, Lian X, Wang H, Yang K, Dai Z, Li Y, Chen X, Wang Q, Yang D, Wang F, Hao F, Wang L
Bioactive materials 2025 Aug;50:475-493
Bioactive materials 2025 Aug;50:475-493
Irisin Alleviates Autoimmune Uveitis Through Promoting Retinal Microglial M1 to M2 Phenotypic Polarization Mediated by HIF-1α Pathway.
Wang M, Huang X, Shu J, Li H, Yang T, Li N, Yang P
Inflammation 2025 Aug;48(4):1716-1727
Inflammation 2025 Aug;48(4):1716-1727
Triamcinolone Acetonide Protects Against Light-Induced Retinal Degeneration by Activating Anti-Inflammatory STAT6/Arg1 Signaling in Microglia.
Tang X, Liu W, Liang J, Zhu X, Ge X, Fang D, Ling L, Yuan F, Zeng K, Chen Q, Zhang G, Gong L, Zhang S
Inflammation 2025 Aug;48(4):1557-1574
Inflammation 2025 Aug;48(4):1557-1574
Rescuing inflammatory microenvironment induced senescence via MgO immune mediated asymmetric short fibers for accelerating diabetic wound repair.
Chen Y, Liu Q, Guan J, Zheng C, Shi S, Zheng W, Guan J, Mao Y
Materials today. Bio 2025 Aug;33:102079
Materials today. Bio 2025 Aug;33:102079
Polyphenol-based self-assembled nanoparticles treating uveitis by inflammation-oxidative stress suppression.
Chen H, Yang Q, Li M, Ren M, Liu S, An G, Ren Y, Liu P, Du L, Sun X, Jin X
Materials today. Bio 2025 Aug;33:102052
Materials today. Bio 2025 Aug;33:102052
Electroacupuncture Improves Microglial Polarization Induced-Inflammation by Regulating the TGF-β/Smad-3 Signaling Pathway in Ischemic Stroke Mice.
Yang G, Zhang L, Yuan Y, Mazhar M, Zhang D, Liu Y, Chen G, Fan X
CNS neuroscience & therapeutics 2025 Aug;31(8):e70567
CNS neuroscience & therapeutics 2025 Aug;31(8):e70567
Black phosphorus nanosheets promote neuronal differentiation of neural stem cells through adhesion and pinocytosis for spinal cord injury repair.
Chen L, Shi L, Wei T, Liu H, Wang Z, Wang H, Li N, Feng S
Acta biomaterialia 2025 Aug;202:529-544
Acta biomaterialia 2025 Aug;202:529-544
SAA1 deletion ameliorates cardiac injury after myocardial infarction by promoting macrophage transformation to reparative subtype.
Xu Y, Zhang K, Sun C, Zhang Q, Li B, Yuan Y, Wang J, Zhang J, Chang Y, Wang S, Li J
Molecular immunology 2025 Aug;184:1-12
Molecular immunology 2025 Aug;184:1-12
Layered double hydroxide-delivered si-NEAT1 inhibits breast cancer immune evasion and malignant progression by modulating the miR-141-3p/PD-L1 axis.
Xiao Y, Ran R, Zhu C, Ji Y, Shi J, Ye R, Geng C, Li R, Tang G, Wang W, Yang Q, Chen C
Bioorganic chemistry 2025 Aug;163:108742
Bioorganic chemistry 2025 Aug;163:108742
Improved prebiotic-based "shield" equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota.
Wang Y, Su X, Liu Y, Hu L, Kang L, Xu C, Sun Z, Sun C, Guo H, Shen S
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4225-4247
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4225-4247
Exosomal miR-218 secreted from endothelial progenitor cells mitigates acute lung injury in sepsis mice by inhibiting HMGA1 in alveolar macrophages.
Liang G, Zeng M, Wang Q, Wang W, Liu J, Gao M, He Z
Stem cell research & therapy 2025 Aug 6;16(1):431
Stem cell research & therapy 2025 Aug 6;16(1):431
Identification of the role of ARG1 in the fibrotic process of benign airway stenosis using bioinformatics analysis.
Chen Y, Xu C, Shi D, Yang C, Tong S, Qin Y, Zhang W, Li X, Tian S, Dong Y, Shi H, Bai C
Journal of thoracic disease 2025 Aug 31;17(8):5639-5653
Journal of thoracic disease 2025 Aug 31;17(8):5639-5653
Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice.
Lu S, Cao J, Song Z, Gong F, Yang P, Ge J, He Y, Han Z, Hou G, Zhang Z, Yang Y, Teng Y, Zhang Z, Zou J, Cheng L, Yang H
Nature communications 2025 Aug 30;16(1):8127
Nature communications 2025 Aug 30;16(1):8127
Preventive and therapeutic effects of Tanshinone IIA on spinal cord injury without radiographic abnormality by regulating microglial phenotype polarization.
Xu L, Ma Y, Jiang G, Cao Z, Song J, Gao Y, Wang G, Fan J, Yang Y, Yu X
International immunopharmacology 2025 Aug 28;161:115086
International immunopharmacology 2025 Aug 28;161:115086
Lovastatin alleviates DSS-induced colitis by modulating macrophage polarization via the PPARγ-NF-κB pathway.
Zhu Q, Zeng C, Peng W, Chen H, Huang H, Zhou Y, Huang C, Zhao C
International immunopharmacology 2025 Aug 28;161:115068
International immunopharmacology 2025 Aug 28;161:115068
Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer.
Yang H, Zhang X, Zhang S, Yang Y, Chen Y, Jiang Y, Lu Q, Liu L, Lao M, Du W, Sun K, He L, Shi J, Liu X, Song J, Lu N, Huang J, Huang J, Zhou R, Lu X, Liang T, Bai X
Nature communications 2025 Aug 22;16(1):7827
Nature communications 2025 Aug 22;16(1):7827
USP18 promotes ferroptosis in lipopolysaccharide-induced human kidney organoids by stabilizing STING1.
Yang H, Zhao L, Kong W, Liu S, Zhou Q, Lang X, Lan L, Wang Y
Cell biology and toxicology 2025 Aug 20;41(1):126
Cell biology and toxicology 2025 Aug 20;41(1):126
Sanren decoction ameliorates ulcerative colitis by modulating gut microbiota and macrophage polarization to enhance intestinal barrier function.
Zhang S, Li B, Han X, Ruan L, Fu X, Chen Y, Wan H, Zhu X, Liu D, Yi B
Chinese medicine 2025 Aug 20;20(1):128
Chinese medicine 2025 Aug 20;20(1):128
MRO/HNRNPU/CCL5 feedback loop amplifies M2 macrophage and breast cancer cell crosstalk to drive progression.
Zeng Z, Bao X, Lei S, Tang W, Tai H, Wang L, Li D, Liu S, Chen T
Journal of translational medicine 2025 Aug 15;23(1):920
Journal of translational medicine 2025 Aug 15;23(1):920
Urea cycle dysregulation drives metabolic stress and neurodegeneration in Parkinson's disease.
Zhang S, Wan G, Qiu Y, Zhang M, Deng H, Wang Q, Hu J, Gui J, Chen D, Huang B, Ran J
NPJ Parkinson's disease 2025 Aug 11;11(1):237
NPJ Parkinson's disease 2025 Aug 11;11(1):237
Interleukin-6 enhances localized immune cell infiltration and deep vein thrombosis resolution at the distal edge.
Achyar AC, Hara T, Adinata A, Suzuki Y, Nishimori M, Hirata KI, Otake H, Emoto N
American journal of physiology. Heart and circulatory physiology 2025 Aug 1;329(2):H603-H621
American journal of physiology. Heart and circulatory physiology 2025 Aug 1;329(2):H603-H621
Functional anti-inflammatory mesoporous silica nanoplatform for Synergistic and Targeted abdominal aortic aneurysm treatment.
Wu Z, Wu X, Meng X, Lei J, Zeng C, Pu H, Liu Y, Xu Z, Wu X, Huang S, Qin J, Liu J, Lu X, Li B
Journal of colloid and interface science 2025 Apr;683(Pt 1):1040-1054
Journal of colloid and interface science 2025 Apr;683(Pt 1):1040-1054
Dexmedetomidine Improves Long-term Neurological Outcomes by Promoting Oligodendrocyte Genesis and Myelination in Neonatal Rats Following Hypoxic-ischemic Brain Injury.
Xue H, Ding Z, Chen X, Yang X, Jia Y, Zhao P, Wu Z
Molecular neurobiology 2025 Apr;62(4):4866-4880
Molecular neurobiology 2025 Apr;62(4):4866-4880
Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways.
Wu N, Zhao Y, Xiao M, Liu H, Chen H, Liu B, Wang X, Fan X
Inflammation 2025 Apr;48(2):950-962
Inflammation 2025 Apr;48(2):950-962
MYCN/MNX1 Axis Drives NSCLC Progression by Inducing Macrophage M2 Polarization and CD8(+) T Cell Apoptosis via the Wnt/β-Catenin Pathway.
Cao C, Lai H, Shi Y
Journal of biochemical and molecular toxicology 2025 Apr;39(4):e70251
Journal of biochemical and molecular toxicology 2025 Apr;39(4):e70251
Implantation of MSC spheroid-derived 3D decellularized ECM enriched with the MSC secretome ameliorates traumatic brain injury and promotes brain repair.
Chen GH, Sia KC, Liu SW, Kao YC, Yang PC, Ho CH, Huang SC, Lee PY, Liang MZ, Chen L, Huang CC
Biomaterials 2025 Apr;315:122941
Biomaterials 2025 Apr;315:122941
Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair.
Wang P, Chen Z, Li P, Al Mamun A, Ning S, Zhang J, Tang C, Sun T, Xiao J, Wei X, Wu F
Materials today. Bio 2025 Apr;31:101518
Materials today. Bio 2025 Apr;31:101518
Exosome-loaded tannic acid-thioctic acid hydrogel enhances wound healing in coagulation disorders.
Tu Y, Zheng W, Ding Z, Xiang J, Yang Q, Liu Y, Cao J, Shen Y, Tang Z, Lin S, Fan L, Xu Y, Chen B
Materials today. Bio 2025 Apr;31:101496
Materials today. Bio 2025 Apr;31:101496
An injectable responsive exosome-releasing hydrogel based on sodium alginate restores motor and bladder function by alleviating the injury microenvironment and facilitating distal nerve repair.
Lin Y, Guo Q, Liu Q, Wang W, Lv A, Zhang L, Li L, Gao J, Huang F
International journal of biological macromolecules 2025 Apr;304(Pt 1):140819
International journal of biological macromolecules 2025 Apr;304(Pt 1):140819
Strontium-based quaternary ammonium salt chitosan particles for ultrafast hemostasis of open fracture.
Ji M, Yuan Z, Zhu Y, Han F, Zhao C, Yu X, Chen Z, Huang Y, Jiang H, Shi L, Ye C, Wan F, Tao R, Zhou Z
International journal of biological macromolecules 2025 Apr;304(Pt 1):140752
International journal of biological macromolecules 2025 Apr;304(Pt 1):140752
Itaconate promotes mitophagy to inhibit neuronal ferroptosis after subarachnoid hemorrhage.
Wang G, Li Z, Han W, Tian Q, Liu C, Jiang S, Xiang X, Zhao X, Wang L, Liao J, Li M
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):991-1004
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):991-1004
Exploring the anti-inflammatory effects of Radix Curcumae essential oil in pulmonary sarcoidosis via the TLR4/MyD88/NF-κB pathway.
Mao Z, Lin X, Hu Y, Liu Y, Yu S, Zhou T, Zhang J, Yang X, Tian S, Miao M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156496
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156496
CpG-Based Nanovaccines Enhance Ovarian Cancer Immune Response by Gbp2-Mediated Remodeling of Tumor-Associated Macrophages.
Xiong J, Huang J, Xu H, Wu Q, Zhao J, Chen Y, Fan G, Guan H, Xiao R, He Z, Wu S, Ouyang W, Wang S, Zhang L, Xia P, Zhang W, Wu M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412881
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412881
SMARCC1 promotes M2 macrophage polarization and reduces ferroptosis in lung cancer by activating FLOT1 transcription.
Tao Y, Ji H, Hu W, Jiang G, Yang F, Peng X, Zhang X, Yin Y, Yuan Z, Chen D
Journal of molecular medicine (Berlin, Germany) 2025 Apr;103(4):453-467
Journal of molecular medicine (Berlin, Germany) 2025 Apr;103(4):453-467
S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling.
Cai W, Wu A, Lin Z, Cao W, Pathak JL, Jaspers RT, Li R, Li X, Zheng K, Lin Y, Zhou N, Zhang X, Zhu Y, Zhang Q
Molecular medicine (Cambridge, Mass.) 2025 Apr 7;31(1):128
Molecular medicine (Cambridge, Mass.) 2025 Apr 7;31(1):128
Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mousmodel of Alzheimer's disease.
Chen H, Li N, Liu N, Zhu H, Ma C, Ye Y, Shi X, Luo G, Dong X, Tan T, Wei X, Yin H
Alzheimer's research & therapy 2025 Apr 5;17(1):72
Alzheimer's research & therapy 2025 Apr 5;17(1):72
Prdx5 regulates macrophage polarization by modulating the TLR4/NF-κB pathway to promote apoptosis in chronic prostatitis.
Wu W, Meng T, Wang Y, Chen J, Liang C
International immunopharmacology 2025 Apr 4;151:114332
International immunopharmacology 2025 Apr 4;151:114332
Hybrid membranes-mediated biomimetic-nanoparticle carrying miR-665 for effective tumor treatment by remodeling tumor microenvironment.
Zhang B, Zhang C, Chen C, Hong R, Shen Y, Yao C, Sun J, Zhang Y
International journal of pharmaceutics 2025 Apr 30;675:125479
International journal of pharmaceutics 2025 Apr 30;675:125479
Deficiency of IL-7R attenuates abdominal aortic aneurysms in mice by inhibiting macrophage polarization towards M1 phenotype through the NF-κB pathway.
Xu S, Han X, Yu Y, Qu C, Yang B, Shen B, Liu X
Molecular medicine (Cambridge, Mass.) 2025 Apr 16;31(1):138
Molecular medicine (Cambridge, Mass.) 2025 Apr 16;31(1):138
Parabacteroides distasonis promotes CXCL9 secretion of tumor-associated macrophages and enhances CD8(+)T cell activity to trigger anti-tumor immunity against anti-PD-1 treatment in non-small cell lung cancer mice.
Fan Z, Yi Z, Li S, He J
BMC biotechnology 2025 Apr 16;25(1):30
BMC biotechnology 2025 Apr 16;25(1):30
Nicotinamide mononucleotide supplementation ameliorates testicular damage induced by ischemia-reperfusion through reshaping macrophage and neutrophil inflammatory properties.
Mou H, Zhang X, Ren F, Deng Y, Chi A, Zhan G, Li D, Sun Q, You W, Ge Y, Zhang M, Ju Z
International immunopharmacology 2025 Apr 16;152:114407
International immunopharmacology 2025 Apr 16;152:114407
Inhibition of Rho GEFs attenuates pulmonary fibrosis through suppressing myofibroblast activation and reprogramming profibrotic macrophages.
Luo C, Huang C, Zhu Y, Zhou Y, Qiao Y, Shi C, Gao Y, Guo Y, Wei L
Cell death & disease 2025 Apr 11;16(1):278
Cell death & disease 2025 Apr 11;16(1):278
Tannic acid‑cerium nanoenzymes serve as broad-spectrum antioxidants to alleviate acute kidney injury by modulating macrophage polarization, mitophagy and endoplasmic reticulum stress.
Fu H, Wang Y, Huang B, Liang Z, Li Y, Cao Z, Wu J, Zhao Y
Journal of controlled release : official journal of the Controlled Release Society 2025 Apr 10;380:892-909
Journal of controlled release : official journal of the Controlled Release Society 2025 Apr 10;380:892-909
Lack of ALCAT1 enhances the protective effects of aerobic exercise on kidney in HFpEF mice.
Zhang L, Feng L, Zhao Y, Geng Y, Liu R, Ma Y, Bo W, Xi Y, Tian Z
Life sciences 2025 Apr 1;366-367:123500
Life sciences 2025 Apr 1;366-367:123500
Baicalin ameliorates neuroinflammation by targeting TLR4/MD2 complex on microglia via PI3K/AKT/NF-κB signaling pathway.
Lu Y, Zhou R, Zhu R, Wu X, Liu J, Ma Y, Zhang X, Zhang Y, Yang L, Li Y, Zhang Y, Yan Y, Zhang Q
Neuropharmacology 2025 Apr 1;267:110296
Neuropharmacology 2025 Apr 1;267:110296
Bifunctional TRPV1 Targeted Magnetothermal Switch to Attenuate Osteoarthritis Progression.
Lv Z, Wang P, Li W, Xie Y, Sun W, Jin X, Jiang R, Fei Y, Liu Y, Shi T, Guo H, Sun Z, Lin J, Wang X, Tan G, Wu Y, Bao N, Shi D
Research (Washington, D.C.) 2024;7:0316
Research (Washington, D.C.) 2024;7:0316
Galactomannan inhibits Trichinella spiralis invasion of intestinal epithelium cells and enhances antibody-dependent cellular cytotoxicity related killing of larvae by driving macrophage polarization.
Zhang R, Zhang Y, Yan SW, Cheng YK, Zheng WW, Long SR, Wang ZQ, Cui J
Parasite (Paris, France) 2024;31:6
Parasite (Paris, France) 2024;31:6
Transglutaminase 2 inhibition ameliorates cardiac fibrosis in myocardial infarction by inducing M2 macrophage polarization in vitro and in vivo.
Maimaitijiang A, Huang Q, Wu Y, Sun S, Chen Q
CytoJournal 2024;21:58
CytoJournal 2024;21:58
Mechanistic study of celastrol-mediated inhibition of proinflammatory activation of macrophages in IgA nephropathy via down-regulating ECM1.
Zhao J, Liu H, Chen Q, Xia M, Wan L, Yu W, Liu C, Hao X, Tang C, Chen G, Liu Y, Yuan F, Liu H
International journal of biological sciences 2024;20(14):5731-5746
International journal of biological sciences 2024;20(14):5731-5746
FoxO1-Overexpressed Small Extracellular Vesicles Derived from hPDLSCs Promote Periodontal Tissue Regeneration by Reducing Mitochondrial Dysfunction to Regulate Osteogenesis and Inflammation.
Niu Q, Lin C, Yang S, Rong S, Wei J, Zhao T, Peng Y, Cheng Z, Xie Y, Wang Y
International journal of nanomedicine 2024;19:8751-8768
International journal of nanomedicine 2024;19:8751-8768
Administration of Liposomal-Based Pde3b Gene Therapy Protects Mice Against Collagen-Induced Rheumatoid Arthritis via Modulating Macrophage Polarization.
Chen L, Zhou Q, Fang X, Xu Q, Zou Y, Zhang J
International journal of nanomedicine 2024;19:4411-4427
International journal of nanomedicine 2024;19:4411-4427
HucMSC-Exo Induced N2 Polarization of Neutrophils: Implications for Angiogenesis and Tissue Restoration in Wound Healing.
Yang J, Xie Y, Xia Z, Ji S, Yang X, Yue D, Liu Y, Yang R, Fan Y
International journal of nanomedicine 2024;19:3555-3575
International journal of nanomedicine 2024;19:3555-3575
Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and Polarization.
Ding X, Zhang X, Cao J, Chen S, Chen Y, Yuan K, Chen B, Yang G, Li S, Yang J, Wang G, Tacke F, Lan T
Cellular and molecular gastroenterology and hepatology 2024;18(6):101406
Cellular and molecular gastroenterology and hepatology 2024;18(6):101406
Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation.
Li Y, Dong X, He W, Quan H, Chen K, Cen C, Wei W
Obesity facts 2024;17(1):24-36
Obesity facts 2024;17(1):24-36
New Insights into Roles of IL-7R Gene as a Therapeutic Target Following Intracerebral Hemorrhage.
Cui J, Wang H, Liu S, Zhao Y
Journal of inflammation research 2024;17:399-415
Journal of inflammation research 2024;17:399-415
Pretreated MSCs with IronQ Transplantation Attenuate Microglia Neuroinflammation via the cGAS-STING Signaling Pathway.
Yang G, Kantapan J, Mazhar M, Hu Q, Bai X, Zou Y, Wang H, Yang S, Wang L, Dechsupa N
Journal of inflammation research 2024;17:1643-1658
Journal of inflammation research 2024;17:1643-1658
Inhibition of the MyD88 signaling pathway could upregulates Ghrelin expression to synergistically regulate hepatic Echinococcus multilocularis-infected progression.
Zhu J, Zhou T, Chen G, Wu Y, Chen X, Song Y, Tuohetali A, Gao H, Pang D, Wen H, Aimulajiang K
Frontiers in immunology 2024;15:1512180
Frontiers in immunology 2024;15:1512180
Corilagin alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation via the Olfr2 signaling pathway in vitro and in vivo.
Mao J, Chen Y, Zong Q, Liu C, Xie J, Wang Y, Fisher D, Hien NTT, Pronyuk K, Musabaev E, Li Y, Zhao L, Dang Y
Frontiers in immunology 2024;15:1364161
Frontiers in immunology 2024;15:1364161
Quercetin ameliorates ulcerative colitis by restoring the balance of M2/M1 and repairing the intestinal barrier via downregulating cGAS‒STING pathway.
Gao F, Zhu F, Shuai B, Wu M, Wei C, Yuan Y, Gui Y, Tian Y, Fan H, Wu H
Frontiers in pharmacology 2024;15:1351538
Frontiers in pharmacology 2024;15:1351538
Deciphering m(6)A methylation in monocyte-mediated cardiac fibrosis and monocyte-hitchhiked erythrocyte microvesicle biohybrid therapy.
Li J, Wei L, Hu K, He Y, Gong G, Liu Q, Zhang Y, Zhou K, Guo J, Hua Y, Tang J, Li Y
Theranostics 2024;14(9):3486-3508
Theranostics 2024;14(9):3486-3508
Multifunctionally disordered TiO(2) nanoneedles prevent periprosthetic infection and enhance osteointegration by killing bacteria and modulating the osteoimmune microenvironment.
Chen Y, Zhou L, Guan M, Jin S, Tan P, Fu X, Zhou Z
Theranostics 2024;14(15):6016-6035
Theranostics 2024;14(15):6016-6035
Methyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis.
Chen L, Zhang M, Yang X, Wang Y, Huang T, Li X, Ban Y, Li Q, Yang Q, Zhang Y, Zheng Y, Wang D, Wang X, Shi X, Zhang M, Sun Y, Wu J
Theranostics 2024;14(11):4256-4277
Theranostics 2024;14(11):4256-4277
Genetically engineered electrospinning contributes to spinal cord injury repair by regulating the immune microenvironment.
Sun Y, Wu J, Zhou L, Wang W, Wang H, Sun S, Xu Y, Zhang L, Jiang X, Zhu G, Xi K, Gu Y, Chen L
Frontiers in bioengineering and biotechnology 2024;12:1415527
Frontiers in bioengineering and biotechnology 2024;12:1415527
Propionate-producing engineered probiotics ameliorated murine ulcerative colitis by restoring anti-inflammatory macrophage via the GPR43/HDAC1/IL-10 axis.
Kang G, Wang X, Gao M, Wang L, Feng Z, Meng S, Wu J, Zhu Z, Gao X, Cao X, Huang H
Bioengineering & translational medicine 2024 Sep;9(5):e10682
Bioengineering & translational medicine 2024 Sep;9(5):e10682
Spatiotemporal evolutionary process of osteosarcoma immune microenvironment remodeling and C1QBP-driven drug resistance deciphered through single-cell multi-dimensional analysis.
Wu X, Tang N, Zhao Q, Xiong J
Bioengineering & translational medicine 2024 Sep;9(5):e10654
Bioengineering & translational medicine 2024 Sep;9(5):e10654
Reprogramming exosomes for immunity-remodeled photodynamic therapy against non-small cell lung cancer.
Guo J, Zhao W, Xiao X, Liu S, Liu L, Zhang L, Li L, Li Z, Li Z, Xu M, Peng Q, Wang J, Wei Y, Jiang N
Bioactive materials 2024 Sep;39:206-223
Bioactive materials 2024 Sep;39:206-223
Infection‑associated bile acid disturbance contributes to macrophage activation in patients with cirrhosis.
Su Y, Zhou Q, Wu Q, Ding Y, Jiang M, Zhang X, Wang J, Wang X, Ge C
Molecular medicine reports 2024 Sep;30(3)
Molecular medicine reports 2024 Sep;30(3)
Melatonin reverses EGFR-TKI therapeutic resistance by modulating crosstalk between circadian-related gene signature and immune infiltration patterns in patients with COVID-19 and lung adenocarcinoma.
Dai Z, Lin B, Cao Y, Wang L, Liao K, Guo L, Zhang J
Computers in biology and medicine 2024 Sep;180:108937
Computers in biology and medicine 2024 Sep;180:108937
oHSV2-mGM repolarizes TAMs and cooperates with αPD1 to reprogram the immune microenvironment of residual cancer after radiofrequency ablation.
Zhu L, Huang J, Zhang S, Cai Q, Guo X, Liu B, Chen L, Zheng C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117060
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117060
Metabolic Control During Macrophage Polarization by a Citrate-Functionalized Scaffold for Maintaining Bone Homeostasis.
Wu X, Xia Y, Dai H, Hong C, Zhao Y, Wei W, Zheng D
Advanced healthcare materials 2024 Sep;13(22):e2400770
Advanced healthcare materials 2024 Sep;13(22):e2400770
Nobiletin alleviates macrophage M2 polarization by activating AMPK-mTOR-mediated autophagy in pulmonary fibrosis mice.
Cheng Y, Mei X, Shao W, Zheng J, Yin X, Zhang Q, Li J, Zhao P
International immunopharmacology 2024 Sep 30;139:112792
International immunopharmacology 2024 Sep 30;139:112792
The expansion of MDSCs induced by exosomal PD-L1 promotes the progression of gastric cancer.
Li H, Chen X, Zheng S, Han B, Zhang X, Zheng X, Lu Y, Sun Q, Hu X, Wu J
Journal of translational medicine 2024 Sep 3;22(1):821
Journal of translational medicine 2024 Sep 3;22(1):821
Prophylactic Effects of Betaine on Depression and Anxiety Behaviors in Mice with Dextran Sulfate Sodium-Induced Colitis.
Liu W, Zhong X, Yi Y, Xie L, Zhou W, Cao W, Chen L
Journal of agricultural and food chemistry 2024 Sep 25;72(38):21041-21051
Journal of agricultural and food chemistry 2024 Sep 25;72(38):21041-21051
Macrophage membrane-camouflaged biomimetic nanoparticles for rheumatoid arthritis treatment via modulating macrophage polarization.
Zhou R, Xue S, Cheng Y, Chen Y, Wang Y, Xing J, Liu H, Xu Y, Lin Y, Pei Z, Wei X, Ding J, Li S, Wang K, Yao F, Zhao Y, Ding C, Hu W
Journal of nanobiotechnology 2024 Sep 19;22(1):578
Journal of nanobiotechnology 2024 Sep 19;22(1):578
Ocotillol-Type Pseudoginsenoside-F11 Alleviates Lipopolysaccharide-Induced Acute Kidney Injury through Regulation of Macrophage Function by Suppressing the NF-κB/NLRP3/IL-1β Signaling Pathway.
Wang Y, Zhang J, Yang Z, Li C, Zhang C, Sun S, Jiao Z, Che G, Gao H, Liu J, Li J
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20496-20512
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20496-20512
Mitigating Viral Impact on the Radiation Response of the Lung.
Groves AM, Paris ND, Johnston CJ, Hernady E, Finkelstein J, Lawrence P, Marples B
Radiation research 2024 Sep 1;202(3):552-564
Radiation research 2024 Sep 1;202(3):552-564
Developmental PFOS exposure alters lung inflammation and barrier integrity in juvenile mice.
Lucas JH, Wang Q, Meehan-Atrash J, Pang C, Rahman I
Toxicological sciences : an official journal of the Society of Toxicology 2024 Sep 1;201(1):48-60
Toxicological sciences : an official journal of the Society of Toxicology 2024 Sep 1;201(1):48-60
Mesenchymal Stem Cells Regulate Microglial Polarization via Inhibition of the HMGB1/TLR4 Signaling Pathway in Diabetic Retinopathy.
Tong J, Yao G, Chen Y, Xie H, Zheng X, Sun L, Huang Z, Xie Z
Inflammation 2024 Oct;47(5):1728-1743
Inflammation 2024 Oct;47(5):1728-1743
Suppressed testicular macrophage M1 polarization by HDAC5 enforces insensitivity to LPS-elicited blood-testis barrier damage.
Li H, Hu YF, Wang XR, Ouyang KW, Wang H, Wang KW, Chang W, Zhang J, Yuan Z, Xiong YW, Zhu HL, Yang L, Wang H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Oct;192:114940
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Oct;192:114940
Akkermansia muciniphila ameliorates colonic injury in mice with DSS-induced acute colitis by blocking macrophage pro-inflammatory phenotype switching via the HDAC5/DAB2 axis.
Miao Y, Wang M, Sun H, Zhang Y, Zhou W, Yang W, Duan L, Niu L, Li Z, Chen J, Li Y, Fan A, Xie Q, Wei S, Bai H, Wang C, Chen Q, Wang X, Li Y, Liu J, Han Y, Fan D, Hong L
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119751
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119751
Oncolytic Peptide-Nanoplatform Drives Oncoimmune Response and Reverses Adenosine-Induced Immunosuppressive Tumor Microenvironment.
Wu Y, Lin JY, Zhou YD, Liu HJ, Lu SX, Zhang XK, Guan YY, Nagle DG, Zhang WD, Chen HZ, Luan X
Advanced healthcare materials 2024 Oct;13(26):e2303445
Advanced healthcare materials 2024 Oct;13(26):e2303445
MerTK(+) macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation.
Wu N, Li J, Li L, Yang L, Dong L, Shen C, Sha S, Fu Y, Dong E, Zheng F, Tan Z, Tao J
Science advances 2024 Oct 4;10(40):eado8366
Science advances 2024 Oct 4;10(40):eado8366
Bioactivity-Oriented Separation of "Pepper Alkaloids" from Piper sintenense Hatusima with Potential Antigouty Arthritis Activity.
Yao Z, Li T, Jin M, Fang S, Wang J, Zheng J, Pan K, Zhang J, Zhao G, Yin Z, Huang Y
Journal of agricultural and food chemistry 2024 Oct 30;72(43):23979-23990
Journal of agricultural and food chemistry 2024 Oct 30;72(43):23979-23990
Ouabain Ameliorates Alzheimer's Disease-Associated Neuropathology and Cognitive Impairment in FAD(4T) Mice.
Wang D, Liu J, Zhu Q, Wei X, Zhang X, Chen Q, Zhao Y, Tang H, Xu W
Nutrients 2024 Oct 20;16(20)
Nutrients 2024 Oct 20;16(20)
Neutrophil N1 polarization induced by cardiomyocyte-derived extracellular vesicle miR-9-5p aggravates myocardial ischemia/reperfusion injury.
Zhang Y, Li X, Dai Y, Han Y, Wei X, Wei G, Chen W, Kong S, He Y, Liu H, Ma N, Bin J, Tan N, He P, Liu Y
Journal of nanobiotechnology 2024 Oct 16;22(1):632
Journal of nanobiotechnology 2024 Oct 16;22(1):632
Intermittent fasting attenuates cognitive dysfunction and systemic disease activity in mice with neuropsychiatric systemic lupus erythematosus.
Feng Y, Qin J, Wang P, Lai Y, Tang L, Zhang X, Ren H, Yang M, Huang Q
Life sciences 2024 Oct 15;355:122999
Life sciences 2024 Oct 15;355:122999
Developmental perfluorooctane sulfonic acid exposure exacerbates house dust mite induced allergic responses in adult mice.
Lucas JH, Wang Q, Pang C, Rahman I
The Science of the total environment 2024 Oct 10;946:173768
The Science of the total environment 2024 Oct 10;946:173768
A Novel Trichinella spiralis Galectin Strengthens the Macrophage ADCC Killing of Larvae via Driving M1 Polarization.
Weng M, Zhang R, Zhang Z, Wu J, Zheng W, Lu Q, Long S, Liu R, Wang Z, Cui J
International journal of molecular sciences 2024 Oct 10;25(20)
International journal of molecular sciences 2024 Oct 10;25(20)
A Janus Microsphere Delivery System Orchestrates Immunomodulation and Osteoinduction by Fine-tuning Release Profiles.
Shi Y, Gu J, Zhang C, Mi R, Ke Z, Xie M, Jin W, Shao C, He Y, Shi J, Xie Z
Small (Weinheim an der Bergstrasse, Germany) 2024 Nov;20(46):e2403835
Small (Weinheim an der Bergstrasse, Germany) 2024 Nov;20(46):e2403835
Mesenchymal stem cells improve depressive disorder via inhibiting the inflammatory polarization of microglia.
Wang Q, Xu Y, Zhu S, Jiang L, Yao L, Yu X, Zhang Y, Jia S, Hong M, Zheng J
Journal of psychiatric research 2024 Nov;179:105-116
Journal of psychiatric research 2024 Nov;179:105-116
Implantation of biomimetic polydopamine nanocomposite scaffold promotes optic nerve regeneration through modulating inhibitory microenvironment.
Pan T, Huang Y, Wei J, Lai C, Chen Y, Nan K, Wu W
Journal of nanobiotechnology 2024 Nov 7;22(1):683
Journal of nanobiotechnology 2024 Nov 7;22(1):683
Pancreatic cancer cell-derived migrasomes promote cancer progression by fostering an immunosuppressive tumor microenvironment.
Zhang R, Peng J, Zhang Y, Zheng K, Chen Y, Liu L, Li T, Liu J, Li Y, Yang S, Wang M, Cui M, Zhang X, Gao J, Kleeff J, Liao Q, Liu Q
Cancer letters 2024 Nov 28;605:217289
Cancer letters 2024 Nov 28;605:217289
Taprenepag restores maternal-fetal interface homeostasis for the treatment of neurodevelopmental disorders.
Wang K, Zhang S, Wang Y, Wu X, Wen L, Meng T, Jin X, Li S, Hong Y, Ke J, Xu Y, Yuan H, Hu F
Journal of neuroinflammation 2024 Nov 28;21(1):307
Journal of neuroinflammation 2024 Nov 28;21(1):307
HMGB1 Modulates Macrophage Metabolism and Polarization in Ulcerative Colitis by Inhibiting Cpt1a Expression.
Wang F, Luo L, Wu Z, Wan L, Li F, Wen Z
Frontiers in bioscience (Landmark edition) 2024 Nov 19;29(11):387
Frontiers in bioscience (Landmark edition) 2024 Nov 19;29(11):387
miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization.
Zhou Y, Yuan Y, Yao X, Wang L, Yao L, Tang D, Chen F, Li J
Biology direct 2024 Nov 18;19(1):117
Biology direct 2024 Nov 18;19(1):117
NVP-BHG712 alleviates ovariectomy-induced osteoporosis by modulating osteoclastogenesis.
Liu X, Liu S, Sun H, Zhang J, Li M, Shi Y, Wang G, Chen W, Cao Y, Lu G, Ning Y, Zhao Y
European journal of pharmacology 2024 Nov 15;983:177000
European journal of pharmacology 2024 Nov 15;983:177000
Hippocampal cannabinoid type 2 receptor alleviates chronic neuropathic pain-induced cognitive impairment via microglial DUSP6 pathway in rats.
Xu L, Zhu A, Xu S, Zhao J, Song S, Zhu H, Huang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70152
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70152
Manganese-mediated potentiation of antitumor immune responses by enhancing KLRG1(+) Macrophage function.
Ge L, Guo H, Zhou W, Shi W, Yue J, Wu Y
International immunopharmacology 2024 Nov 15;141:112951
International immunopharmacology 2024 Nov 15;141:112951
PLGA microspheres carrying EMSCs-CM for the effective treatment of murine ulcerative colitis.
Yang W, Zhang X, Wang Z, Zheng X, Wu W, Chen Q
International immunopharmacology 2024 Nov 15;141:112883
International immunopharmacology 2024 Nov 15;141:112883
Exosome-derived circ-001422 promotes tumor-associated macrophage M2 polarization to accelerate the progression of glioma.
Cao W, Zeng Z, Sun J, Chen Y, Kuang F, Luo S, Lan J, Lei S
Communications biology 2024 Nov 13;7(1):1504
Communications biology 2024 Nov 13;7(1):1504
Primate-specific 82-kDa choline acetyltransferase attenuates progression of Alzheimer's disease-like pathology in the APP(NL-G-F) knock-in mouse model.
AlQot HE, Rylett RJ
Scientific reports 2024 Nov 11;14(1):27614
Scientific reports 2024 Nov 11;14(1):27614
Ruxolitinib improves the inflammatory microenvironment, restores glutamate homeostasis, and promotes functional recovery after spinal cord injury.
Cao J, Yu X, Liu J, Fu J, Wang B, Wu C, Zhang S, Chen H, Wang Z, Xu Y, Sui T, Chang J, Cao X
Neural regeneration research 2024 Nov 1;19(11):2499-2512
Neural regeneration research 2024 Nov 1;19(11):2499-2512
Regulatory T cell-derived exosome mediated macrophages polarization for osteogenic differentiation in fracture repair.
Wu T, Wang L, Jian C, Gao C, Liu Y, Fu Z, Shi C
Journal of controlled release : official journal of the Controlled Release Society 2024 May;369:266-282
Journal of controlled release : official journal of the Controlled Release Society 2024 May;369:266-282
Macrophage M2 polarization promotes pulpal inflammation resolution during orthodontic tooth movement.
Li J, Ren H, Zhang Z, Zhang J, Wei F
Journal of cellular and molecular medicine 2024 May;28(9):e18350
Journal of cellular and molecular medicine 2024 May;28(9):e18350
Analysis of the effects of M2 macrophage-derived PDE4C on the prognosis, metastasis and immunotherapy benefit of osteosarcoma.
Pan F, Pan R, Hu R, Zhang H, Lei S, Zhang L, Zhou C, Zeng Z, Tian X, Xie Q
Journal of cellular and molecular medicine 2024 May;28(10):e18395
Journal of cellular and molecular medicine 2024 May;28(10):e18395
MG53/GMs/HA-Dex neural scaffold promotes the functional recovery of spinal cord injury by alleviating neuroinflammation.
Li X, Ji R, Duan L, Hao Z, Su Y, Wang H, Guan F, Ma S
International journal of biological macromolecules 2024 May;267(Pt 2):131520
International journal of biological macromolecules 2024 May;267(Pt 2):131520
Fam96a is essential for the host control of Toxoplasma gondii infection by fine-tuning macrophage polarization via an iron-dependent mechanism.
Liu Z, Wang H, Zhang Z, Ma Y, Jing Q, Zhang S, Han J, Chen J, Xiang Y, Kou Y, Wei Y, Wang L, Wang Y
PLoS neglected tropical diseases 2024 May;18(5):e0012163
PLoS neglected tropical diseases 2024 May;18(5):e0012163
Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation.
Zhang Y, Jiang H, Dong M, Min J, He X, Tan Y, Liu F, Chen M, Chen X, Yin Q, Zheng L, Shao Y, Li X, Chen H
Cell reports 2024 May 28;43(5):114180
Cell reports 2024 May 28;43(5):114180
Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity.
Wang L, Li C, Zhan H, Li S, Zeng K, Xu C, Zou Y, Xie Y, Zhan Z, Yin S, Zeng Y, Chen X, Lv G, Han Z, Zhou D, Zhou D, Yang Y, Zhou A
Cell reports. Medicine 2024 May 21;5(5):101533
Cell reports. Medicine 2024 May 21;5(5):101533
Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway.
Che J, Wang H, Dong J, Wu Y, Zhang H, Fu L, Zhang J
CNS neuroscience & therapeutics 2024 Mar;30(3):e14454
CNS neuroscience & therapeutics 2024 Mar;30(3):e14454
Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis by inhibiting the Wnt/β-catenin pathway.
Xiang W, Yin G, Liu H, Wei J, Yu X, Xie Y, Zhang L, XueTang, Jiang W, Lu N
International journal of biological macromolecules 2024 Mar;261(Pt 1):129670
International journal of biological macromolecules 2024 Mar;261(Pt 1):129670
A multifunctional composite nanoparticle with antibacterial activities, anti-inflammatory, and angiogenesis for diabetic wound healing.
Li X, Qu S, Ouyang Q, Qin F, Guo J, Qin M, Zhang J
International journal of biological macromolecules 2024 Mar;260(Pt 2):129531
International journal of biological macromolecules 2024 Mar;260(Pt 2):129531
Extracellular vesicle mediated targeting delivery of growth differentiation factor-15 improves myocardial repair by reprogramming macrophages post myocardial injury.
Xiao T, Wei J, Cai D, Wang Y, Cui Z, Chen Q, Gu Q, Zou A, Mao L, Chi B, Ji Y, Wang Q, Sun L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116224
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116224
Lentinan inhibits cell invasion via M2 polarization of tumor-associated macrophages and Wnt/β-catenin signaling in non-small cell lung cancer.
Yang Y, Cheng Y, Mu Y, Tang X, Mu X
Chemical biology & drug design 2024 Mar;103(3):e14507
Chemical biology & drug design 2024 Mar;103(3):e14507
Tibial cortex transverse transport promotes ischemic diabetic foot ulcer healing via enhanced angiogenesis and inflammation modulation in a novel rat model.
Qin W, Liu K, Su H, Hou J, Yang S, Pan K, Yang S, Liu J, Zhou P, Lin Z, Zhen P, Mo Y, Fan B, Li Z, Kuang X, Nie X, Hua Q
European journal of medical research 2024 Mar 6;29(1):155
European journal of medical research 2024 Mar 6;29(1):155
Peroxiredoxin 3 has a crucial role in the macrophage polarization by regulating mitochondrial homeostasis.
Huang W, Wang L, Huang Z, Sun Z, Zheng B
Respiratory research 2024 Mar 2;25(1):110
Respiratory research 2024 Mar 2;25(1):110
Protective effect of Tao Hong Si Wu Decoction against inflammatory injury caused by intestinal flora disorders in an ischemic stroke mouse model.
Zhang L, Xue S, Fei C, Yu C, Li J, Li Y, Wang N, Chu F, Pan L, Duan X, Peng D
BMC complementary medicine and therapies 2024 Mar 18;24(1):124
BMC complementary medicine and therapies 2024 Mar 18;24(1):124
SAP130 released by ferroptosis tubular epithelial cells promotes macrophage polarization via Mincle signaling in sepsis acute kidney injury.
Zhang J, Jiang J, Wang B, Wang Y, Qian Y, Suo J, Li Y, Peng Z
International immunopharmacology 2024 Mar 10;129:111564
International immunopharmacology 2024 Mar 10;129:111564
The Anti-Atherosclerotic Effects of Buyang Huanwu Decoction through M1 and M2 Macrophage Polarization in an ApoE Knockout Mouse Model.
Ji M, Mao L, Wei Y, Zhu B, Zhai Y, Zhou X, Tao W, Wang W, Wu H
Journal of physiological investigation 2024 Mar 1;67(2):79-87
Journal of physiological investigation 2024 Mar 1;67(2):79-87
Wogonin alleviates sepsis-induced acute lung injury by modulating macrophage polarization through the SIRT1-FOXO1 pathways.
Ge J, Yang H, Yu N, Lin S, Zeng Y
Tissue & cell 2024 Jun;88:102400
Tissue & cell 2024 Jun;88:102400
Collagen sponge scaffolds loaded with Trichostatin A pretreated BMSCs-derived exosomes regulate macrophage polarization to promote skin wound healing.
Wang T, Xue Y, Zhang W, Zheng Z, Peng X, Zhou Y
International journal of biological macromolecules 2024 Jun;269(Pt 2):131948
International journal of biological macromolecules 2024 Jun;269(Pt 2):131948
Dual-crosslinking gelatin-hyaluronic acid methacrylate based biomimetic PDAC desmoplastic niche enhances tumor-associated macrophages recruitment and M2-like polarization.
Wu D, Gong T, Sun Z, Yao X, Wang D, Chen Q, Guo Q, Li X, Guo Y, Lu Y
International journal of biological macromolecules 2024 Jun;269(Pt 1):131826
International journal of biological macromolecules 2024 Jun;269(Pt 1):131826
CircRNA CDR1as affects functional repair after spinal cord injury and regulates fibrosis through the SMAD pathway.
Wang W, Liu C, He D, Shi G, Song P, Zhang B, Li T, Wei J, Jiang Y, Ma L
Pharmacological research 2024 Jun;204:107189
Pharmacological research 2024 Jun;204:107189
Relieving Macrophage Dysfunction by Inhibiting SREBP2 Activity: A Hypoxic Mesenchymal Stem Cells-Derived Exosomes Loaded Multifunctional Hydrogel for Accelerated Diabetic Wound Healing.
Shi Y, Wang S, Wang K, Yang R, Liu D, Liao H, Qi Y, Qiu K, Hu Y, Wen H, Xu K
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(25):e2309276
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(25):e2309276
Functional Oxidized Hyaluronic Acid Cross-Linked Decellularized Heart Valves for Improved Immunomodulation, Anti-Calcification, and Recellularization.
Wu Y, Chen X, Song P, Li R, Zhou Y, Wang Q, Shi J, Qiao W, Dong N
Advanced healthcare materials 2024 Jun;13(16):e2303737
Advanced healthcare materials 2024 Jun;13(16):e2303737
Exosomes from adipose-derived stem cells regulate macrophage polarization and accelerate diabetic wound healing via the circ-Rps5/miR-124-3p axis.
Yin D, Shen G
Immunity, inflammation and disease 2024 Jun;12(6):e1274
Immunity, inflammation and disease 2024 Jun;12(6):e1274
Targeted Repair of Spinal Cord Injury Based on miRNA-124-3p-Loaded Mesoporous Silica Camouflaged by Stem Cell Membrane Modified with Rabies Virus Glycoprotein.
Fan X, Shi L, Yang Z, Li Y, Zhang C, Bai B, Chen L, Yilihamu EE, Qi Z, Li W, Xiao P, Liu M, Qiu J, Yang F, Ran N, Shang Y, Liu J, Zhang T, Kong X, Liu H, Zhou H, Feng S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(21):e2309305
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(21):e2309305
Chishao - Fuzi herbal pair restore the macrophage M1/M2 balance in acute-on-chronic liver failure.
Tan N, Jian G, Peng J, Tian X, Chen B
Journal of ethnopharmacology 2024 Jun 28;328:118010
Journal of ethnopharmacology 2024 Jun 28;328:118010
Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression.
Cheng J, Yuan L, Yu S, Gu B, Luo Q, Wang X, Zhao Y, Gai C, Li T, Liu W, Wang Z, Liu D, Ho RCM, Ho CSH
Behavioural brain research 2024 Jun 25;468:115028
Behavioural brain research 2024 Jun 25;468:115028
Potential Involvement of M1 Macrophage and VLA4/VCAM-1 Pathway in the Valvular Damage Due to Rheumatic Heart Disease.
Xian S, Li Y, Bai L, Tang S, Meng Z, Wen H, Huang F, Zeng Z
Frontiers in bioscience (Landmark edition) 2024 Jun 18;29(6):219
Frontiers in bioscience (Landmark edition) 2024 Jun 18;29(6):219
Wogonoside alleviates microglia-mediated neuroinflammation via TLR4/MyD88/NF-κB signaling axis after spinal cord injury.
Zhu R, Zhang Y, He W, Sun Y, Zhao X, Yan Y, Zhang Q
European journal of pharmacology 2024 Jun 15;973:176566
European journal of pharmacology 2024 Jun 15;973:176566
Involvement of P2X7R-mediated microglia polarization and neuroinflammation in the response to electroacupuncture on post-stroke memory impairment.
Lin B, Wang M, Chen X, Chai L, Ni J, Huang J
Brain research bulletin 2024 Jun 15;212:110967
Brain research bulletin 2024 Jun 15;212:110967
Distinct roles of TREM2 in central nervous system cancers and peripheral cancers.
Zhong J, Xing X, Gao Y, Pei L, Lu C, Sun H, Lai Y, Du K, Xiao F, Yang Y, Wang X, Shi Y, Bai F, Zhang N
Cancer cell 2024 Jun 10;42(6):968-984.e9
Cancer cell 2024 Jun 10;42(6):968-984.e9
A novel p55PIK signaling peptide inhibitor alleviates neuroinflammation via the STAT3/NF-kB signaling pathway in experimental stroke.
Liu Y, Leng C, Li Y, Zhou M, Ye X, Li C, Xia X, Sun B, Shu X, Liu W
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2024 Jul;33(7):107736
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2024 Jul;33(7):107736
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization.
Yang Y, Zhao C, Yang Z, Du C, Chang Z, Wen X, Zhang X, Liu Y, Hu L, Gao Z
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):875-886
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):875-886
Neuroimmune modulating and energy supporting nanozyme-mimic scaffold synergistically promotes axon regeneration after spinal cord injury.
Zheng G, Yu W, Xu Z, Yang C, Wang Y, Yue Z, Xiao Q, Zhang W, Wu X, Zang F, Wang J, Wang L, Yuan WE, Hu B, Chen H
Journal of nanobiotechnology 2024 Jul 5;22(1):399
Journal of nanobiotechnology 2024 Jul 5;22(1):399
Effect of luteolin on glioblastoma's immune microenvironment and tumor growth suppression.
Zong S, Li X, Zhang G, Hu J, Li H, Guo Z, Zhao X, Chen J, Wang Y, Jing Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155611
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155611
Ze-Qi-Tang formula inhibits MDSCs glycolysis through the down-regulation of p21/Hif1α/Glut1 signal in psoriatic-like mice.
Zhu Y, Chen X, Zou Y, Su L, Yan X, Zhu X, Hou Y, Liu M, Jiang W, Zou C, Chen X, Xu Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155544
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155544
Ru(II)-Photoactive Agents for Targeting ER Stress and Immunogenic Cell Death.
Denison M, Ullrich A, Herroon MK, Mecca S, Turro C, Podgorski I, Gibson H, Kodanko JJ
bioRxiv : the preprint server for biology 2024 Jul 22;
bioRxiv : the preprint server for biology 2024 Jul 22;
Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats.
Yan Q, Liu H, Sun S, Yang Y, Fan D, Yang Y, Zhao Y, Song Z, Chen Y, Zhu R, Zhang Z
Journal of nanobiotechnology 2024 Jul 18;22(1):423
Journal of nanobiotechnology 2024 Jul 18;22(1):423
MSCs-exosomes can promote macrophage M2 polarization via exosomal miR-21-5p through Mesenteric injection: a promising way to attenuate murine colitis.
Qian W, Wu E, Chen H, Yao J, Wang J, Zhou Y, Bai Y, Wang S, Shen C, Li Y, Zhang Y
Journal of Crohn's & colitis 2024 Jul 13;
Journal of Crohn's & colitis 2024 Jul 13;
Inhibition of TREM-1 alleviates neuroinflammation by modulating microglial polarization via SYK/p38MAPK signaling pathway after traumatic brain injury.
Zhao T, Zhou Y, Zhang D, Han D, Ma J, Li S, Li T, Hu S, Li Z
Brain research 2024 Jul 1;1834:148907
Brain research 2024 Jul 1;1834:148907
Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor‑associated macrophages.
Gao X, Long R, Qin M, Zhu W, Wei L, Dong P, Chen J, Luo J, Feng J
International journal of molecular medicine 2024 Jan;53(1)
International journal of molecular medicine 2024 Jan;53(1)
MCPIP1 alleviates depressive‑like behaviors in mice by inhibiting the TLR4/TRAF6/NF‑κB pathway to suppress neuroinflammation.
An Q, Xia J, Pu F, Shi S
Molecular medicine reports 2024 Jan;29(1)
Molecular medicine reports 2024 Jan;29(1)
Exosomes secreted by ST3GAL5(high) cancer cells promote peritoneal dissemination by establishing a premetastatic microenvironment.
Horie M, Takagane K, Itoh G, Kuriyama S, Yanagihara K, Yashiro M, Umakoshi M, Goto A, Arita J, Tanaka M
Molecular oncology 2024 Jan;18(1):21-43
Molecular oncology 2024 Jan;18(1):21-43
Inhibition of cGAS-STING pathway by stress granules after activation of M2 macrophages by human mesenchymal stem cells against drug induced liver injury.
Wang Y, She S, Li W, Zhu J, Li X, Yang F, Dai K
Molecular immunology 2024 Jan;165:42-54
Molecular immunology 2024 Jan;165:42-54
Bushen Antai recipe alleviates embryo absorption by enhancing immune tolerance and angiogenesis at the maternal-fetal interface via mobilizing MDSCs in abortion-prone mice.
Liu Z, Geng Y, Huang Y, Hu R, Li F, Ding J, Ma W, Dong H, Song K, Xu X, Wu X, Song Y, Zhang M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155164
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155164
Diosgenin alters LPS-induced macrophage polarization by activating PPARγ/NF-κB signaling pathway.
Xiang X, Xin X, Hou Y, Deng Y, Liu X, Yu W
International immunopharmacology 2024 Jan 5;126:111270
International immunopharmacology 2024 Jan 5;126:111270
Adipose-derived stem cell exosomes promote tumor characterization and immunosuppressive microenvironment in breast cancer.
Zhu Q, Cao Y, Yuan J, Hu Y
Cancer immunology, immunotherapy : CII 2024 Jan 31;73(2):39
Cancer immunology, immunotherapy : CII 2024 Jan 31;73(2):39
Maimendong decoction regulates M2 macrophage polarization to suppress pulmonary fibrosis via PI3K/Akt/FOXO3a signalling pathway-mediated fibroblast activation.
Shuangshuang H, Mengmeng S, Lan Z, Fang Z, Yu L
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117308
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117308
κ-Opioid receptor activation attenuates osteoarthritis synovitis by regulating macrophage polarization through the NF-κB pathway.
Shi Y, Tao H, Li X, Zhang L, Li C, Sun W, Chu M, Chen K, Zhu P, Wang Q, Gu C, Wang L, Yang X, Hao Y
Acta biochimica et biophysica Sinica 2024 Jan 25;56(1):82-95
Acta biochimica et biophysica Sinica 2024 Jan 25;56(1):82-95
Rosmarinic acid against cognitive impairment via RACK1/HIF-1α regulated microglial polarization in sepsis-surviving mice.
Liu DY, Wu Y, Feng ZQ, Yu Y, Cai HW, Liao SP, Zeng T, Zhu L, Wang X, Wan LH
Chemico-biological interactions 2024 Jan 25;388:110830
Chemico-biological interactions 2024 Jan 25;388:110830
METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner.
Cao F, Chen G, Xu Y, Wang X, Tang X, Zhang W, Song X, Yang X, Zeng W, Xie J
Cell death & disease 2024 Jan 13;15(1):43
Cell death & disease 2024 Jan 13;15(1):43
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
Qin DE, Liang W, Yu Y, Whelan EC, Yuan X, Wang ZL, Wu XW, Cao ZR, Hua SY, Yin L, Shi L, Liang T
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116906
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116906
TREM2 regulates BV2 microglia activation and influences corticosterone-induced neuroinflammation in depressive disorders.
Shi J, Wang X, Kang C, Liu J, Ma C, Yang L, Hu J, Zhao N
Brain research 2024 Jan 1;1822:148664
Brain research 2024 Jan 1;1822:148664
VSIG4 ameliorates intestinal inflammation through inhibiting macrophages NLRP3 inflammasome and pyroptosis.
Liao Y, Deng C, Wang X
Tissue & cell 2024 Feb;86:102285
Tissue & cell 2024 Feb;86:102285
Liver-Derived Ketogenesis via Overexpressing HMGCS2 Promotes the Recovery of Spinal Cord Injury.
Sun X, Zhang B, Sun K, Li F, Hu D, Chen J, Kong F, Xie Y
Advanced biology 2024 Feb;8(2):e2300481
Advanced biology 2024 Feb;8(2):e2300481
C-C Motif Chemokine 2 Regulates Macrophage Polarization and Contributes to Myocardial Infarction Healing.
Chen L, Pan D, Zhang Y, Zhang E, Ma L
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2024 Feb;44(2):68-79
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2024 Feb;44(2):68-79
Targeted transplantation of engineered mitochondrial compound promotes functional recovery after spinal cord injury by enhancing macrophage phagocytosis.
Xu J, Shi C, Yuan F, Ding Y, Xie Y, Liu Y, Zhu F, Lu H, Duan C, Hu J, Jiang L
Bioactive materials 2024 Feb;32:427-444
Bioactive materials 2024 Feb;32:427-444
Edaravone dexborneol alleviates cerebral ischemia-reperfusion injury through NF-κB/NLRP3 signal pathway.
Shen G, Lou C, Li Q, Zhao B, Luo Y, Wu F, Jiao D, Fang M, Geng Y
Anatomical record (Hoboken, N.J. : 2007) 2024 Feb;307(2):372-384
Anatomical record (Hoboken, N.J. : 2007) 2024 Feb;307(2):372-384
MKP-1 regulates the inflammatory activation of microglia against Alzheimer's disease.
Li J, Wang L, Zeng Q, He J, Tang Q, Wang K, He G
CNS neuroscience & therapeutics 2024 Feb;30(2):e14409
CNS neuroscience & therapeutics 2024 Feb;30(2):e14409
Multi-Omics Profiling Identifies Microglial Annexin A2 as a Key Mediator of NF-κB Pro-inflammatory Signaling in Ischemic Reperfusion Injury.
Tian X, Yang W, Jiang W, Zhang Z, Liu J, Tu H
Molecular & cellular proteomics : MCP 2024 Feb;23(2):100723
Molecular & cellular proteomics : MCP 2024 Feb;23(2):100723
Dual siRNA-Loaded Cell Membrane Functionalized Matrix Facilitates Bone Regeneration with Angiogenesis and Neurogenesis.
Qiao F, Zou Y, Bie B, Lv Y
Small (Weinheim an der Bergstrasse, Germany) 2024 Feb;20(8):e2307062
Small (Weinheim an der Bergstrasse, Germany) 2024 Feb;20(8):e2307062
Troxerutin dampened hypothalamic neuroinflammation via microglial IL-22/IL-22R1/IRF3 activation in dihydrotestosterone-induced polycystic ovary syndrome rats.
Gao Z, Tan H, Song X, Zhuang T, Kong R, Wang Y, Yan X, Yao R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155280
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155280
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Peng D, Huang Z, Yang H, Luo Y, Wu Z
Immunity, inflammation and disease 2024 Feb;12(2):e1189
Immunity, inflammation and disease 2024 Feb;12(2):e1189
Multipathway Regulation for Targeted Atherosclerosis Therapy Using Anti-miR-33-Loaded DNA Origami.
Ma Y, Wang Q, Du S, Luo J, Sun X, Jia B, Ge J, Dong J, Jiang S, Li Z
ACS nano 2024 Feb 6;
ACS nano 2024 Feb 6;
Endothelial Mitochondria Transfer to Melanoma Induces M2-Type Macrophage Polarization and Promotes Tumor Growth by the Nrf2/HO-1-Mediated Pathway.
Kuo FC, Tsai HY, Cheng BL, Tsai KJ, Chen PC, Huang YB, Liu CJ, Wu DC, Wu MC, Huang B, Lin MW
International journal of molecular sciences 2024 Feb 3;25(3)
International journal of molecular sciences 2024 Feb 3;25(3)
FAM76B regulates PI3K/Akt/NF-κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA.
Wang J, Zhao X, Wang Q, Zheng X, Simayi D, Zhao J, Yang P, Mao Q, Xia H
Cellular and molecular life sciences : CMLS 2024 Feb 29;81(1):107
Cellular and molecular life sciences : CMLS 2024 Feb 29;81(1):107
Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis.
Luckett T, Abudula M, Ireland L, Glenn M, Bellomo G, Stafferton R, Halloran C, Ghaneh P, Jones R, Schmid MC, Mielgo A
Cancer research 2024 Feb 15;84(4):527-544
Cancer research 2024 Feb 15;84(4):527-544
SLC15A3 is transcriptionally regulated by HIF1α and p65 to worsen neuroinflammation in experimental ischemic stroke.
Yu S, Yang J, Zhang R, Guo Q, Wang L
Molecular neurobiology 2024 Dec;61(12):10302-10317
Molecular neurobiology 2024 Dec;61(12):10302-10317
Novel injectable adhesive hydrogel loaded with exosomes for holistic repair of hemophilic articular cartilage defect.
Yang Q, Liu G, Chen G, Chen G, Chen K, Fan L, Tu Y, Chen J, Shi Z, Chen C, Liu S, Deng G, Deng X, Sun C, Li X, Yang S, Zheng S, Chen B
Bioactive materials 2024 Dec;42:85-111
Bioactive materials 2024 Dec;42:85-111
Microglial EPOR Contribute to Sevoflurane-induced Developmental Fine Motor Deficits Through Synaptic Pruning in Mice.
He D, Shi X, Liang L, Zhao Y, Ma S, Cao S, Liu B, Gao Z, Zhang X, Fan Z, Kuang F, Zhang H
Neuroscience bulletin 2024 Dec;40(12):1858-1874
Neuroscience bulletin 2024 Dec;40(12):1858-1874
Intervention of Tanshinone IIA on the PGK1-PDHK1 Pathway to Reprogram Macrophage Phenotype After Myocardial Infarction.
Gao S, Yang Z, Li D, Wang B, Zheng X, Li C, Fan G
Cardiovascular drugs and therapy 2024 Dec;38(6):1359-1373
Cardiovascular drugs and therapy 2024 Dec;38(6):1359-1373
Integrated-omics profiling unveils the disparities of host defense to ECM scaffolds during wound healing in aged individuals.
Chen SD, Chu CY, Wang CB, Yang Y, Xu ZY, Qu YL, Man Y
Biomaterials 2024 Dec;311:122685
Biomaterials 2024 Dec;311:122685
TBK1 is involved in M-CSF-induced macrophage polarization through mediating the IRF5/IRF4 axis.
Li Y, Ji L, Liu C, Li J, Wen D, Li Z, Yu L, Guo M, Zhang S, Duan W, Yi L, Bi Y, Bu H, Li C, Liu Y
The FEBS journal 2024 Dec;291(23):5214-5235
The FEBS journal 2024 Dec;291(23):5214-5235
An advanced chitosan based sponges dressing system with antioxidative, immunoregulation, angiogenesis and neurogenesis for promoting diabetic wound healing.
Fan X, Su Z, Zhang W, Huang H, He C, Wu Z, Zhang P
Materials today. Bio 2024 Dec;29:101361
Materials today. Bio 2024 Dec;29:101361
Biodegradable exosome-engineered hydrogels for the prevention of peritoneal adhesions via anti-oxidation and anti-inflammation.
Wang W, Ren Y, Yu Q, Jiang L, Yu C, Yue Z, Wang Y, Lu J, Che P, Li J, Sun H
Materials today. Bio 2024 Dec;29:101312
Materials today. Bio 2024 Dec;29:101312
Injectable hyaluronate-based hydrogel with a dynamic/covalent dual-crosslinked architecture for bone tissue engineering: Enhancing osteogenesis and immune regulation.
Guo K, Li G, Yu Q, Yang Y, Liu H, Zhao Y, Huang Y, Zhang H, Li W
International journal of biological macromolecules 2024 Dec;282(Pt 5):137249
International journal of biological macromolecules 2024 Dec;282(Pt 5):137249
Indole-3-Carboxaldehyde Inhibits Inflammatory Response and Lipid Accumulation in Macrophages Through the miR-1271-5p/HDAC9 Pathway.
Luo W, Meng J, Yu XH, Zhang ZZ, Wang G, He J
Journal of cellular and molecular medicine 2024 Dec;28(24):e70263
Journal of cellular and molecular medicine 2024 Dec;28(24):e70263
EVA1B facilitates esophageal squamous carcinoma progression and recruitment of immunosuppressive myeloid-derived suppressor cells in the tumor microenvironment.
Xia T, Zhang Y, Peng H, Jia X, Yang D, Wei L, Li T, Yao W
Pharmacological research 2024 Dec;210:107521
Pharmacological research 2024 Dec;210:107521
The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.
Zhao Y, Zheng G, Yang S, Liu S, Wu Y, Miao Y, Liang Z, Hua Y, Zhang J, Shi J, Li D, Cheng Y, Zhang Y, Chen Y, Fan G, Ma C
British journal of pharmacology 2024 Dec;181(23):4822-4844
British journal of pharmacology 2024 Dec;181(23):4822-4844
Swimming upregulates APOL3 through regulating macrophage polarization to inhibit glycolysis and the development of melanoma.
Lyu Z, Mahenderan A, Radhakrishnan AKGK, Chin YS, Yin C
3 Biotech 2024 Dec;14(12):307
3 Biotech 2024 Dec;14(12):307
Cardiac Urea Cycle Activation by Time-Restricted Feeding Protects Against Pressure Overload-Induced Heart Failure.
Tan Y, Li M, Li H, Guo Y, Zhang B, Wu G, Li J, Zhang Q, Sun Y, Gao F, Yi W, Zhang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2407677
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2407677
Salidroside alleviates ferroptosis in FAC-induced Age-related macular degeneration models by activating Nrf2/SLC7A11/GPX4 axis.
Zhu M, Yu J
International immunopharmacology 2024 Dec 5;142(Pt A):113041
International immunopharmacology 2024 Dec 5;142(Pt A):113041
Long-term hypothermia amplified neuroprotection by antagonizing intracranial pressure rebound after severe traumatic brain injury in rats.
Sun X, Xu S, Wang J, Li X, Sun H, Zhao W
Neuroreport 2024 Dec 4;35(17):1107-1116
Neuroreport 2024 Dec 4;35(17):1107-1116
Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1(+) Macrophages for Infectious Bone Defect Regeneration.
Wu H, Chen C, Li J, Yu D, Wu X, Huang H, Tang Z, Wu Q, Yan S, Wang N, Wang M, Wei F, Yu Y, Wang D, Shi M, Yue X, Cao P, Zheng Z, Li X, Guo B, Shi L, Guo Z
ACS nano 2024 Dec 31;18(52):35575-35594
ACS nano 2024 Dec 31;18(52):35575-35594
Tet2 modulates M2 macrophage polarization via mRNA 5-methylcytosine in allergic rhinitis.
Fan W, Liu P, Tan L, Lv H, Zhou H, Tao Z, Xu Y
International immunopharmacology 2024 Dec 25;143(Pt 3):113495
International immunopharmacology 2024 Dec 25;143(Pt 3):113495
Sulforaphane potentiates the efficacy of chemoradiotherapy in glioblastoma by selectively targeting thioredoxin reductase 1.
Ge Y, Ge Z, Tian F, Tai X, Chen D, Sun S, Shi Z, Yin J, Wei G, Li D, Wang L, Xu W, Tong M, Liu F, Zhao L, Qian X, Ge X
Cancer letters 2024 Dec 24;611:217429
Cancer letters 2024 Dec 24;611:217429
NIR-II Imaging for Tracking the Spatiotemporal Immune Microenvironment in Atherosclerotic Plaques.
Shen L, Chen M, Su Y, Bi Y, Shu G, Chen W, Lu C, Zhao Z, Lv L, Zou J, Chen X, Ji J
ACS nano 2024 Dec 17;18(50):34171-34185
ACS nano 2024 Dec 17;18(50):34171-34185
Exosomes from human bone marrow MSCs alleviate PD-1/PD-L1 inhibitor-induced myocardial injury in melanoma mice by regulating macrophage polarization and pyroptosis.
Zhou B, Qin Q, Fang Y, Liu X, Zhang M, Wang S, Zhong L, Guo R
Life sciences 2024 Dec 1;358:123108
Life sciences 2024 Dec 1;358:123108
Autophagy-mediated activation of the AIM2 inflammasome enhances M1 polarization of microglia and exacerbates retinal neovascularization.
Liu X, Zhou Q, Meng J, Zuo H, Li R, Zhang R, Lu H, Zhang Z, Li H, Zeng S, Tian M, Wang H, Hu K, Li N, Mao L, Hou S
MedComm 2024 Aug;5(8):e668
MedComm 2024 Aug;5(8):e668
Fucoidan improving spinal cord injury recovery: Modulating microenvironment and promoting remyelination.
Shu H, Zhang X, Pu Y, Zhang Y, Huang S, Ma J, Cao L, Zhou X
CNS neuroscience & therapeutics 2024 Aug;30(8):e14903
CNS neuroscience & therapeutics 2024 Aug;30(8):e14903
A2 reactive astrocyte-derived exosomes alleviate cerebral ischemia-reperfusion injury by delivering miR-628.
Wang Y, Li H, Sun H, Xu C, Sun H, Wei W, Song J, Jia F, Zhong D, Li G
Journal of cellular and molecular medicine 2024 Aug;28(16):e70004
Journal of cellular and molecular medicine 2024 Aug;28(16):e70004
A gelatin methacryloyl (GelMA) treated with gallic acid and coated with specially designed nanoparticles derived from ginseng enhances the healing of wounds in diabetic rats.
Yu YL, Zheng JC, Duan P, Cheng YN, Zhang H, Zheng L, Yu ZR, Xu JM, Hu HX, Pan ZY
International journal of biological macromolecules 2024 Aug;274(Pt 1):133372
International journal of biological macromolecules 2024 Aug;274(Pt 1):133372
A ROS-responsive and scavenging hydrogel for postoperative abdominal adhesion prevention.
Zhang T, Huang Y, Gong Y, Shi X, Xiao D, Ren L, Dai X, Zeng Z, Zhao C
Acta biomaterialia 2024 Aug;184:98-113
Acta biomaterialia 2024 Aug;184:98-113
Inhibition of cGAS attenuates neonatal hypoxic-ischemic encephalopathy via regulating microglia polarization and pyroptosis.
Shen H, Lu H, Mao L, Song L
Translational pediatrics 2024 Aug 31;13(8):1378-1394
Translational pediatrics 2024 Aug 31;13(8):1378-1394
Pterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3/Nrf1-mediated microglial activation.
Chen Y, He W, Qiu J, Luo Y, Jiang C, Zhao F, Wei H, Meng J, Long T, Zhang X, Yang L, Xu Q, Wang J, Zhang C
Cellular & molecular biology letters 2024 Aug 28;29(1):114
Cellular & molecular biology letters 2024 Aug 28;29(1):114
Neural epidermal growth factor-like 1 protein (Nell-1) alleviates periodontal tissue destruction in periodontitis by regulating the ratio of M2/M1 macrophage phenotypes.
Ni C, Liao W, Nie H, Ge R, Liu R, Zou X, Yuan Z, Yan F
International immunopharmacology 2024 Aug 20;137:112522
International immunopharmacology 2024 Aug 20;137:112522
Psoralen protects neurons and alleviates neuroinflammation by regulating microglial M1/M2 polarization via inhibition of the Fyn-PKCδ pathway.
Guo Y, Xu S, Pan X, Xin W, Cao W, Ma W, Li L, Shen Q, Li Z
International immunopharmacology 2024 Aug 20;137:112493
International immunopharmacology 2024 Aug 20;137:112493
Adipose-derived stem cell exosomes loaded with icariin attenuated M1 polarization of macrophages via inhibiting the TLR4/Myd88/NF-κB signaling pathway.
Yan Q, Song C, Liu H, Li Y, Ma J, Zhao Y, Song Z, Chen Y, Zhu R, Zhang Z
International immunopharmacology 2024 Aug 20;137:112448
International immunopharmacology 2024 Aug 20;137:112448
Inhibiting PRMT1 protects against CoNV by regulating macrophages through the FGF2/PI3K/Akt pathway.
Gao Y, Mao J, Zhang R, Deng Q, Wang Y, Pan Y, Liudi S, Wang Y, Fan X, Yang Y, Wan S
European journal of pharmacology 2024 Aug 15;977:176673
European journal of pharmacology 2024 Aug 15;977:176673
CCR5 antagonist maraviroc alleviates doxorubicin-induced neuroinflammation and neurobehavioral deficiency by regulating NF-κB/NLRP3 signaling in a breast cancer mouse model.
Wu Y, Che J, Dong J, Zhang X, Deng Y, Chen W, Zhang J
Neuropharmacology 2024 Aug 15;254:109981
Neuropharmacology 2024 Aug 15;254:109981
Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia/Macrophage M1 Polarization and JAK2/STAT3 Signaling Pathway.
Ji R, Hao Z, Wang H, Su Y, Yang W, Li X, Duan L, Guan F, Ma S
Journal of agricultural and food chemistry 2024 Aug 14;72(32):17964-17976
Journal of agricultural and food chemistry 2024 Aug 14;72(32):17964-17976
Integrative analysis of network pharmacology and proteomics reveal the protective effect of Xiaoqinglong Decotion on neutrophilic asthma.
Liao G, Yan Q, Zhang M, Zhang X, Yang J, Huang H, Liu X, Jiang Y, Gong J, Zhan S, Li D, Huang X
Journal of ethnopharmacology 2024 Aug 10;330:118102
Journal of ethnopharmacology 2024 Aug 10;330:118102
H3K18 lactylation-mediated VCAM1 expression promotes gastric cancer progression and metastasis via AKT-mTOR-CXCL1 axis.
Zhao Y, Jiang J, Zhou P, Deng K, Liu Z, Yang M, Yang X, Li J, Li R, Xia J
Biochemical pharmacology 2024 Apr;222:116120
Biochemical pharmacology 2024 Apr;222:116120
Tumor necrosis factor α-induced protein 8-like-2 controls microglia phenotype via metabolic reprogramming in BV2 microglial cells and responses to neuropathic pain.
Li Y, Yin C, Jiang J, Yang H, Zhang F, Xing Y, Wang W, Lu C
The international journal of biochemistry & cell biology 2024 Apr;169:106541
The international journal of biochemistry & cell biology 2024 Apr;169:106541
Calorie restriction mimetic, resveratrol, attenuates hepatic ischemia and reperfusion injury through enhancing efferocytosis of macrophages via AMPK/STAT3/S1PR1 pathway.
Yao X, Liu Y, Mao M, Yang L, Zhan Q, Xiao J
The Journal of nutritional biochemistry 2024 Apr;126:109587
The Journal of nutritional biochemistry 2024 Apr;126:109587
Dehydroandrographolide facilitates M2 macrophage polarization by downregulating DUSP3 to inhibit sepsis-associated acute kidney injury.
Shao Y, Yu W, Cai H
Immunity, inflammation and disease 2024 Apr;12(4):e1249
Immunity, inflammation and disease 2024 Apr;12(4):e1249
Integration of network pharmacology and serum medicinal chemistry to investigate the pharmacological mechanisms of QiZhuYangGan Decoction in the treatment of hepatic fibrosis.
Deng JW, Yuan S, Shi LP, Chen X, Liu J, Chen ZW, Tan KY, Yang Q, Cao WF
Journal of ethnopharmacology 2024 Apr 6;323:117730
Journal of ethnopharmacology 2024 Apr 6;323:117730
Pyxinol Fatty Acid Ester Derivatives J16 against AKI by Selectively Promoting M1 Transition to M2c Macrophages.
Wang Y, Li C, Chen J, Cui X, Wang B, Wang Y, Wang D, Liu J, Li J
Journal of agricultural and food chemistry 2024 Apr 3;72(13):7074-7088
Journal of agricultural and food chemistry 2024 Apr 3;72(13):7074-7088
Electroacupuncture promotes macrophage/microglial M2 polarization and suppresses inflammatory pain through AMPK.
Nan FB, Gu YX, Wang JL, Chen SD
Neuroreport 2024 Apr 3;35(6):343-351
Neuroreport 2024 Apr 3;35(6):343-351
Bioactive fiber-reinforced hydrogel to tailor cell microenvironment for structural and functional regeneration of myotendinous junction.
Sun Y, Sheng R, Cao Z, Liu C, Li J, Zhang P, Du Y, Mo Q, Yao Q, Chen J, Zhang W
Science advances 2024 Apr 26;10(17):eadm7164
Science advances 2024 Apr 26;10(17):eadm7164
Mas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice.
Deng X, Ren J, Chen K, Zhang J, Zhang Q, Zeng J, Li T, Tang Q, Lin J, Zhu J
Journal of neuroinflammation 2024 Apr 24;21(1):106
Journal of neuroinflammation 2024 Apr 24;21(1):106
Chrysin Inhibits TAMs-Mediated Autophagy Activation via CDK1/ULK1 Pathway and Reverses TAMs-Mediated Growth-Promoting Effects in Non-Small Cell Lung Cancer.
Tang X, Luo X, Wang X, Zhang Y, Xie J, Niu X, Lu X, Deng X, Xu Z, Wu F
Pharmaceuticals (Basel, Switzerland) 2024 Apr 17;17(4)
Pharmaceuticals (Basel, Switzerland) 2024 Apr 17;17(4)
Intratumor microbiome-derived butyrate promotes lung cancer metastasis.
Ma Y, Chen H, Li H, Zheng M, Zuo X, Wang W, Wang S, Lu Y, Wang J, Li Y, Wang J, Qiu M
Cell reports. Medicine 2024 Apr 16;5(4):101488
Cell reports. Medicine 2024 Apr 16;5(4):101488
Adhesive hydrogel releases protocatechualdehyde-Fe(3+) complex to promote three healing stages for accelerated therapy of oral ulcers.
Wang Y, Pan Z, Cui J, Zhang X, Li D, Sun H, Yang B, Li Y
Acta biomaterialia 2024 Apr 1;178:68-82
Acta biomaterialia 2024 Apr 1;178:68-82
P-Glycoprotein Exacerbates Brain Injury Following Experimental Cerebral Ischemia by Promoting Proinflammatory Microglia Activation.
Chen Y, Fei X, Liu G, Li X, Huang L, Yang LZ, Li Y, Xu B, Fang W
Oxidative medicine and cellular longevity 2023;2023:6916819
Oxidative medicine and cellular longevity 2023;2023:6916819
Periventricular Microglia Polarization and Morphological Changes Accompany NLRP3 Inflammasome-Mediated Neuroinflammation after Hypoxic-Ischemic White Matter Damage in Premature Rats.
Yang L, Zhang Y, Yu X, Li D, Liu N, Xue X, Fu J
Journal of immunology research 2023;2023:5149306
Journal of immunology research 2023;2023:5149306
Identifying Macrophage-Related Genes in Ulcerative Colitis Using Weighted Coexpression Network Analysis and Machine Learning.
Hong S, Wang H, Chan S, Zhang J, Chen B, Ma X, Chen X
Mediators of inflammation 2023;2023:4373840
Mediators of inflammation 2023;2023:4373840
Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation.
Wang S, Tian Z, Lu Y, Huang Z, Fan Y, Li B, Zheng H, Wu X, Wang M, Zhao J, Xie J
International journal of biological sciences 2023;19(5):1597-1615
International journal of biological sciences 2023;19(5):1597-1615
α-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated Receptor γ Simultaneously.
Wu YJ, Zhang SS, Yin Q, Lei M, Wang QH, Chen WG, Luo TT, Zhou P, Ji CL
Drug design, development and therapy 2023;17:563-577
Drug design, development and therapy 2023;17:563-577
Integrated Analysis of Non-Coding RNA and mRNA Expression Profiles in Exosomes from Lung Tissue with Sepsis-Induced Acute Lung Injury.
Deng W, Lu Y, Hu P, Zhang Q, Li S, Yang D, Zhao N, Qian K, Liu F
Journal of inflammation research 2023;16:3879-3895
Journal of inflammation research 2023;16:3879-3895
Spinal cannabinoid receptor 2 activation alleviates neuropathic pain by regulating microglia and suppressing P2X7 receptor.
Zhou Y, Xu Y, Yang J, Yu Z, Wang W, Yuan M, Wang Y, Bai Q, Li Z
Frontiers in molecular neuroscience 2023;16:1061220
Frontiers in molecular neuroscience 2023;16:1061220
Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.
Yu C, Zhu Q, Ma C, Luo C, Nie L, Cai H, Wang Q, Wang F, Ren H, Yan H, Xu K, Zhou L, Zhang C, Lu G, Lu Z, Zhu Y, Liu S
Frontiers in immunology 2023;14:1289795
Frontiers in immunology 2023;14:1289795
Jianpi Yangzheng Xiaozheng decoction alleviates gastric cancer progression via suppressing exosomal PD-L1.
Chen Y, Liu J, Chen Y, Zhang R, Tao J, Chen X, Wang H, Sun Q, Wu J, Liu S
Frontiers in pharmacology 2023;14:1159829
Frontiers in pharmacology 2023;14:1159829
Human umbilical cord mesenchymal stem cell-derived exosomes promote murine skin wound healing by neutrophil and macrophage modulations revealed by single-cell RNA sequencing.
Liu Y, Zhang M, Liao Y, Chen H, Su D, Tao Y, Li J, Luo K, Wu L, Zhang X, Yang R
Frontiers in immunology 2023;14:1142088
Frontiers in immunology 2023;14:1142088
Modulation of gut microbiota alleviates cerebral ischemia/reperfusion injury in rats by inhibiting M1 polarization of microglia.
Li HJ, Li DQ, Zhang YL, Ding XF, Gao HT, Zhu Y, Liu J, Zhang LX, Chen J, Chen G, Yu Y
Frontiers in pharmacology 2023;14:1123387
Frontiers in pharmacology 2023;14:1123387
Lycium barbarum polysaccharide alleviates dextran sodium sulfate-induced inflammatory bowel disease by regulating M1/M2 macrophage polarization via the STAT1 and STAT6 pathways.
Wang J, Gao H, Xie Y, Wang P, Li Y, Zhao J, Wang C, Ma X, Wang Y, Mao Q, Xia H
Frontiers in pharmacology 2023;14:1044576
Frontiers in pharmacology 2023;14:1044576
TSAb Modulates Microglia M1 Polarization via Activation of the TSHR-Mediated NF-κB Signaling Pathway.
Liu Y, Yang H, Wu X, Kuang Y, Ban B, Liang Z, Li L, Huang Z, Lu D, Qin Y, Liang X, Luo Z
Neuroendocrinology 2023;113(4):470-478
Neuroendocrinology 2023;113(4):470-478
Ferroptosis-dependent breast cancer cell-derived exosomes inhibit migration and invasion of breast cancer cells by suppressing M2 macrophage polarization.
Yi C, Wu S, Duan Q, Liu L, Li L, Luo Y, Wang A
PeerJ 2023;11:e15060
PeerJ 2023;11:e15060
Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction.
Ge L, Wang K, Lin H, Tao E, Xia W, Wang F, Mao C, Feng Y
Frontiers in bioengineering and biotechnology 2023;11:1129538
Frontiers in bioengineering and biotechnology 2023;11:1129538
Aβ Induces Neuroinflammation and Microglial M1 Polarization via cGAS-STING-IFITM3 Signaling Pathway in BV-2 Cells.
Wu Z, Tang W, Ibrahim FEEM, Chen X, Yan H, Tao C, Wang Z, Guo Y, Fu Y, Wang Q, Ge Y
Neurochemical research 2023 Sep;48(9):2881-2894
Neurochemical research 2023 Sep;48(9):2881-2894
BMP7 Attenuates Neuroinflammation after Spinal Cord Injury by Suppressing the Microglia Activation and Inducing Microglial Polarization Via the STAT3 Pathway.
Wei X, Huang C, Chen K, Liu S, Wang M, Yang L, Wang Y
Neurochemical research 2023 Sep;48(9):2687-2700
Neurochemical research 2023 Sep;48(9):2687-2700
Electroacupuncture alleviates postoperative pain through inhibiting neuroinflammation via stimulator of interferon genes/type-1 interferon pathway.
Ding YY, Xu F, Wang YF, Han LL, Huang SQ, Zhao S, Ma LL, Zhang TH, Zhao WJ, Chen XD
Journal of integrative medicine 2023 Sep;21(5):496-508
Journal of integrative medicine 2023 Sep;21(5):496-508
Mechanical stiffness promotes skin fibrosis through Piezo1-mediated arginine and proline metabolism.
He J, Fang B, Shan S, Li Q
Cell death discovery 2023 Sep 26;9(1):354
Cell death discovery 2023 Sep 26;9(1):354
Resveratrol alleviates DSS-induced IBD in mice by regulating the intestinal microbiota-macrophage-arginine metabolism axis.
Xu X, Ocansey DKW, Pei B, Zhang Y, Wang N, Wang Z, Mao F
European journal of medical research 2023 Sep 2;28(1):319
European journal of medical research 2023 Sep 2;28(1):319
Trichinella spiralis dipeptidyl peptidase 1 suppressed macrophage cytotoxicity by promoting M2 polarization via the STAT6/PPARγ pathway.
Yan SW, Zhang R, Guo X, Wang BN, Long SR, Liu RD, Wang ZQ, Cui J
Veterinary research 2023 Sep 13;54(1):77
Veterinary research 2023 Sep 13;54(1):77
Yangqing Chenfei formula alleviates crystalline silica induced pulmonary inflammation and fibrosis by suppressing macrophage polarization.
Xinrong T, Runsu H, Xinguang L, Peng Z, Yange T, Jiansheng LI
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Oct;43(6):1126-1139
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Oct;43(6):1126-1139
Targeting upregulation of the immunosuppressive activity of MDSCs with indirubin as a novel strategy to alleviate psoriasis.
Hou Y, Zhang H, Zhu Y, He X, Li W, Su L, Liu M, Chen X, Shen F, Chen X, Jiang W, Zou C, Xu Z
International immunopharmacology 2023 Oct;123:110710
International immunopharmacology 2023 Oct;123:110710
Geniposide ameliorates atherosclerosis by regulating macrophage polarization via perivascular adipocyte-derived CXCL14.
He P, Wang H, Cheng S, Hu F, Zhang L, Chen W, Xu Y, Zhang Y, Gu Y, Li Z, Jin Y, Liu X, Jia Y
Journal of ethnopharmacology 2023 Oct 5;314:116532
Journal of ethnopharmacology 2023 Oct 5;314:116532
Lactobacillus casei combined with Lactobacillus reuteri alleviate pancreatic cancer by inhibiting TLR4 to promote macrophage M1 polarization and regulate gut microbial homeostasis.
Zhu Z, Yi B, Tang Z, Chen X, Li M, Xu T, Zhao Z, Tang C
BMC cancer 2023 Oct 30;23(1):1044
BMC cancer 2023 Oct 30;23(1):1044
Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization.
Yan L, Hou C, Liu J, Wang Y, Zeng C, Yu J, Zhou T, Zhou Q, Duan S, Xiong W
Science China. Life sciences 2023 Nov;66(11):2571-2586
Science China. Life sciences 2023 Nov;66(11):2571-2586
Macrophage Sult2b1 promotes pathological neovascularization in age-related macular degeneration.
Wang Y, Liu Y, Wang Y, Wu Y, Chen Z, Wang F, Wan X, Wang F, Sun X
Life science alliance 2023 Nov;6(11)
Life science alliance 2023 Nov;6(11)
Macrophage RAGE deficiency prevents myocardial fibrosis by repressing autophagy-mediated macrophage alternative activation.
He J, Wei L, Tan S, Liang B, Liu J, Lu L, Wang T, Wang J, Huang Y, Chen Z, Li H, Zhang L, Zhou Z, Cao Y, Ye X, Yang Z, Xian S, Wang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23259
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23259
Berberine ameliorates collagen-induced arthritis in mice by restoring macrophage polarization via AMPK/mTORC1 pathway switching glycolytic reprogramming.
Cheng JW, Yu Y, Zong SY, Cai WW, Wang Y, Song YN, Xian H, Wei F
International immunopharmacology 2023 Nov;124(Pt B):111024
International immunopharmacology 2023 Nov;124(Pt B):111024
Peroxisome proliferator-activated receptor gamma agonist pioglitazone alleviates hemorrhage-induced thalamic pain and neuroinflammation.
Li D, He L, Yuan C, Ai Y, Yang JJ
International immunopharmacology 2023 Nov;124(Pt B):110991
International immunopharmacology 2023 Nov;124(Pt B):110991
ASIC1a-CMPK2-mediated M1 macrophage polarization exacerbates chondrocyte senescence in osteoarthritis through IL-18.
Dong L, Zhao Y, Sun C, Ou Yang Z, Chen F, Hu W, Zhang H, Wang Y, Zhu R, Cheng Y, Chen Y, Li S, Wang K, Ding C, Zhou R, Hu W
International immunopharmacology 2023 Nov;124(Pt A):110878
International immunopharmacology 2023 Nov;124(Pt A):110878
Chromofungin, a chromogranin A-derived peptide, protects against sepsis-induced acute lung injury by inhibiting LBP/TLR4-dependent inflammatory signaling.
Zhou W, Kang S, Wang F, Qin Y, Liu J, Xiao X, Chen X, Zhang D
European journal of pharmacology 2023 Nov 5;958:176043
European journal of pharmacology 2023 Nov 5;958:176043
Nuclear receptor corepressor 1 deficiency exacerbates asthma by modulating macrophage polarization.
Hou C, Yan L, Sun K, Zhou T, Zou Y, Xiong W, Duan SZ
Cell death discovery 2023 Nov 29;9(1):429
Cell death discovery 2023 Nov 29;9(1):429
Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization.
Zhu Y, Liu Y, Ma Y, Chen L, Huang H, Huang S, Zhang H, He Y, Tan C, He Y, Qiang L
Cell reports 2023 Nov 28;42(11):113430
Cell reports 2023 Nov 28;42(11):113430
FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression.
Hu WM, Li M, Ning JZ, Tang YQ, Song TB, Li LZ, Zou F, Cheng F, Yu WM
Journal of experimental & clinical cancer research : CR 2023 Nov 2;42(1):290
Journal of experimental & clinical cancer research : CR 2023 Nov 2;42(1):290
Electroacupuncture regulates microglial polarization via inhibiting NF-κB/COX2 pathway following traumatic brain injury.
Zhang XH, Cui H, Zheng SM, Lu Y, Yuan HW, Zhang L, Wang HH, Du RS
Brain research 2023 Nov 1;1818:148516
Brain research 2023 Nov 1;1818:148516
Ursolic acid promotes microglial polarization toward the M2 phenotype via PPARγ regulation of MMP2 transcription.
Wang Y, Qiu L, Deng S, Liu F, He Z, Li M, Wang Y
Neurotoxicology 2023 May;96:81-91
Neurotoxicology 2023 May;96:81-91
Activation of glucagon-like peptide-1 receptor in microglia exerts protective effects against sepsis-induced encephalopathy via attenuating endoplasmic reticulum stress-associated inflammation and apoptosis in a mouse model of sepsis.
Yi H, Duan Y, Song R, Zhou Y, Cui Y, Liu C, Mao Z, Hu J, Zhou F
Experimental neurology 2023 May;363:114348
Experimental neurology 2023 May;363:114348
Silk Fibroin and Sericin Differentially Potentiate the Paracrine and Regenerative Functions of Stem Cells Through Multiomics Analysis.
Zhang Y, Sheng R, Chen J, Wang H, Zhu Y, Cao Z, Zhao X, Wang Z, Liu C, Chen Z, Zhang P, Kuang B, Zheng H, Shen C, Yao Q, Zhang W
Advanced materials (Deerfield Beach, Fla.) 2023 May;35(20):e2210517
Advanced materials (Deerfield Beach, Fla.) 2023 May;35(20):e2210517
Baicalein ameliorates Alzheimer's disease via orchestration of CX3CR1/NF-κB pathway in a triple transgenic mouse model.
Xie XM, Hao JJ, Shi JZ, Zhou YF, Liu PF, Wang F, Zheng XM, Yu XY, Wang CC, Yan Y, Du GH, Song JK, He YY, Pang XB
International immunopharmacology 2023 May;118:109994
International immunopharmacology 2023 May;118:109994
Host genetic background regulates the capacity for anti-tumor antibody-dependent phagocytosis.
Glassbrook JE, Hackett JB, Muñiz MC, Bross M, Dyson G, Movahhedin N, Ullrich A, Gibson HM
bioRxiv : the preprint server for biology 2023 May 9;
bioRxiv : the preprint server for biology 2023 May 9;
Mollugin ameliorates murine allergic airway inflammation by inhibiting Th2 response and M2 macrophage activation.
Li X, Hou R, Ding H, Gao X, Wei Z, Qi T, Fang L
European journal of pharmacology 2023 May 5;946:175630
European journal of pharmacology 2023 May 5;946:175630
Danggui-Shaoyao-San Promotes Amyloid-β Clearance through Regulating Microglia Polarization via Trem2 in BV2 Cells.
Chen G, Han M, Chen Y, Lei Y, Li M, Wang L, Wang C, Hu Y, Niu J, Yang C, Mo Y, Wang Q, Yang L, Chang X
Journal of integrative neuroscience 2023 May 15;22(3):72
Journal of integrative neuroscience 2023 May 15;22(3):72
Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization.
Shu N, Zhang Z, Wang X, Li R, Li W, Liu X, Zhang Q, Jiang Z, Tao L, Zhang L, Hou S
Investigative ophthalmology & visual science 2023 May 1;64(5):21
Investigative ophthalmology & visual science 2023 May 1;64(5):21
γ-Glutamylcysteine rescues mice from TNBS-driven inflammatory bowel disease through regulating macrophages polarization.
Zhou J, Yan X, Bi X, Lu S, Liu X, Yang C, Shi Y, Luo L, Yin Z
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Mar;72(3):603-621
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Mar;72(3):603-621
Three-dimensional cellular visualization in mouse apical periodontitis using combined whole-mount staining and optical tissue clearing.
Tazawa K, Sasaki H
Journal of oral biosciences 2023 Mar;65(1):132-135
Journal of oral biosciences 2023 Mar;65(1):132-135
Lnc-17Rik promotes the immunosuppressive function of Myeloid-Derived suppressive cells in esophageal cancer.
Wen J, Xuan B, Gao Y, Liu Y, Wang L, He L, Meng X, Zhou T, Tao Y, Guo K, Wang Y
Cellular immunology 2023 Mar;385:104676
Cellular immunology 2023 Mar;385:104676
Realizing Highly Efficient Sonodynamic Bactericidal Capability through the Phonon-Electron Coupling Effect Using Two-Dimensional Catalytic Planar Defects.
Mao C, Jin W, Xiang Y, Zhu Y, Wu J, Liu X, Wu S, Zheng Y, Cheung KMC, Yeung KWK
Advanced materials (Deerfield Beach, Fla.) 2023 Mar;35(9):e2208681
Advanced materials (Deerfield Beach, Fla.) 2023 Mar;35(9):e2208681
miR-449a ameliorates acute rejection after liver transplantation via targeting procollagen-lysine1,2-oxoglutarate5-dioxygenase 1 in macrophages.
Cao ZR, Zheng WX, Jiang YX, Chai H, Gong JH, Zhao MJ, Yan P, Liu YY, Liu XY, Huang ZT, Yang H, Peng DD, Zong KZ, Wu ZJ
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Mar;23(3):336-352
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Mar;23(3):336-352
Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis.
Gou Y, Wang H, Wang T, Wang H, Wang B, Jiao N, Yu Y, Cao Y, Wang H, Zhang Z
Immunology 2023 Mar;168(3):389-402
Immunology 2023 Mar;168(3):389-402
Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.
He D, Fu S, Ye B, Wang H, He Y, Li Z, Li J, Gao X, Liu D
Journal of neuroinflammation 2023 Mar 29;20(1):86
Journal of neuroinflammation 2023 Mar 29;20(1):86
Porcine Reproductive and Respiratory Syndrome Virus Modulates the Switch of Macrophage Polarization from M1 to M2 by Upregulating MoDC-Released sCD83.
Gong X, Ma T, Zhang Q, Wang Y, Song C, Lai M, Zhang C, Fang X, Chen X
Viruses 2023 Mar 17;15(3)
Viruses 2023 Mar 17;15(3)
Fecal microbiota transplantation and short-chain fatty acids protected against cognitive dysfunction in a rat model of chronic cerebral hypoperfusion.
Su SH, Chen M, Wu YF, Lin Q, Wang DP, Sun J, Hai J
CNS neuroscience & therapeutics 2023 Jun;29 Suppl 1(Suppl 1):98-114
CNS neuroscience & therapeutics 2023 Jun;29 Suppl 1(Suppl 1):98-114
MAGL regulates synovial macrophage polarization vis inhibition of mitophagy in osteoarthritic pain.
Gu C, Chen M, Li X, Geng D, Wang C
Molecular medicine reports 2023 Jun;27(6)
Molecular medicine reports 2023 Jun;27(6)
Reversing inflammatory microenvironment by a single intra-articular injection of multi-stimulus responsive lipogel to relieve rheumatoid arthritis and promote joint repair.
Tao J, Yang P, Gao M, Zhang F, Wu Y, Jiang Y, Ning Y, Li Z, Ai F
Materials today. Bio 2023 Jun;20:100622
Materials today. Bio 2023 Jun;20:100622
Influence of the irradiated pulmonary microenvironment on macrophage and T cell dynamics.
Groves AM, Misra R, Clair G, Hernady E, Olson H, Orton D, Finkelstein J, Marples B, Johnston CJ
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2023 Jun;183:109543
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2023 Jun;183:109543
Celastrol-loaded biomimetic nanodrug ameliorates APAP-induced liver injury through modulating macrophage polarization.
Zheng J, Yang N, Wan Y, Cheng W, Zhang G, Yu S, Yang B, Liu X, Chen X, Ding X, Wu L, Yu X
Journal of molecular medicine (Berlin, Germany) 2023 Jun;101(6):699-716
Journal of molecular medicine (Berlin, Germany) 2023 Jun;101(6):699-716
Material Stiffness in Cooperation with Macrophage Paracrine Signals Determines the Tenogenic Differentiation of Mesenchymal Stem Cells.
Sheng R, Liu J, Zhang W, Luo Y, Chen Z, Chi J, Mo Q, Wang M, Sun Y, Liu C, Zhang Y, Zhu Y, Kuang B, Yan C, Liu H, Backman LJ, Chen J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(17):e2206814
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(17):e2206814
Endothelial progenitor cell-derived exosomes promote anti-inflammatory macrophages via SOCS3/JAK2/STAT3 axis and improve the outcome of spinal cord injury.
Yuan F, Peng W, Yang Y, Xu J, Liu Y, Xie Y, Huang T, Shi C, Ding Y, Li C, Qin T, Xie S, Zhu F, Lu H, Huang J, Hu J
Journal of neuroinflammation 2023 Jun 30;20(1):156
Journal of neuroinflammation 2023 Jun 30;20(1):156
Repetitive Low-Level Blast Exposure via Akt/NF-κB Signaling Pathway Mediates the M1 Polarization of Mouse Alveolar Macrophage MH-S Cells.
Geng C, Wang X, Chen J, Sun N, Wang Y, Li Z, Han L, Hou S, Fan H, Li N, Gong Y
International journal of molecular sciences 2023 Jun 25;24(13)
International journal of molecular sciences 2023 Jun 25;24(13)
Klotho enhances bone regenerative function of hPDLSCs via modulating immunoregulatory function and cell autophagy.
Niu Q, Chen H, Ou Q, Yang S, Peng Y, Xie Y, Yu L, Cheng Z, Cao Y, Wang Y
Journal of orthopaedic surgery and research 2023 Jun 2;18(1):400
Journal of orthopaedic surgery and research 2023 Jun 2;18(1):400
Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle.
Nasir NJM, Heemskerk H, Jenkins J, Hamadee NH, Bunte R, Tucker-Kellogg L
eLife 2023 Jun 2;12
eLife 2023 Jun 2;12
Hybrid Cell Membrane-Functionalized Matrixes for Modulating Inflammatory Microenvironment and Improving Bone Defect Repair.
Qiao F, Lv Y
Advanced healthcare materials 2023 Jul;12(19):e2203047
Advanced healthcare materials 2023 Jul;12(19):e2203047
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
Liu P, Zhou Y, Shi J, Wang F, Yang X, Zheng X, Wang Y, He Y, Xie X, Pang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154801
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154801
SGLT2 inhibitor dapagliflozin alleviates intramyocardial hemorrhage and adverse ventricular remodeling via suppressing hepcidin in myocardial ischemia-reperfusion injury.
Chen R, Zhang Y, Zhang H, Zhou H, Tong W, Wu Y, Ma M, Chen Y
European journal of pharmacology 2023 Jul 5;950:175729
European journal of pharmacology 2023 Jul 5;950:175729
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation.
Sun W, Wang Q, Zhang R, Zhang N
Food & function 2023 Jul 31;14(15):7247-7269
Food & function 2023 Jul 31;14(15):7247-7269
Selenium-Doped Mesoporous Bioactive Glass Regulates Macrophage Metabolism and Polarization by Scavenging ROS and Promotes Bone Regeneration In Vivo.
Chen D, Liang Z, Su Z, Huang J, Pi Y, Ouyang Y, Luo T, Guo L
ACS applied materials & interfaces 2023 Jul 26;15(29):34378-34396
ACS applied materials & interfaces 2023 Jul 26;15(29):34378-34396
Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats.
Liu J, Cao C, Jin Y, Wang Y, Ma X, Li J, Guo S, Yang J, Niu J, Liang X
iScience 2023 Jul 21;26(7):107022
iScience 2023 Jul 21;26(7):107022
Adenosine kinase promotes post-infarction cardiac repair by epigenetically maintaining reparative macrophage phenotype.
Zhang M, Wang C, Wang R, Xu J, Wang Z, Yan J, Cai Y, Li L, Huo Y, Dong S
Journal of molecular and cellular cardiology 2023 Jan;174:88-100
Journal of molecular and cellular cardiology 2023 Jan;174:88-100
Dehydrocorydaline alleviates sleep deprivation-induced persistent postoperative pain in adolescent mice through inhibiting microglial P2Y(12) receptor expression in the spinal cord.
Yang H, Zhang Y, Duan Q, Ni K, Jiao Y, Zhu J, Sun J, Zhang W, Ma Z
Molecular pain 2023 Jan-Dec;19:17448069231216234
Molecular pain 2023 Jan-Dec;19:17448069231216234
Wutou decoction attenuates the synovial inflammation of collagen-induced arthritis rats via regulating macrophage M1/M2 type polarization.
Lin W, Shen P, Huang Y, Han L, Ba X, Huang Y, Yan J, Li T, Xu L, Qin K, Chen Z, Tu S
Journal of ethnopharmacology 2023 Jan 30;301:115802
Journal of ethnopharmacology 2023 Jan 30;301:115802
Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis.
Yang N, Li M, Wu L, Song Y, Yu S, Wan Y, Cheng W, Yang B, Mou X, Yu H, Zheng J, Li X, Yu X
Journal of nanobiotechnology 2023 Jan 13;21(1):13
Journal of nanobiotechnology 2023 Jan 13;21(1):13
Castor1 overexpression regulates microglia M1/M2 polarization via inhibiting mTOR pathway.
Hu H, Lu X, Huang L, He Y, Liu X, Wang Y, Duan C
Metabolic brain disease 2023 Feb;38(2):699-708
Metabolic brain disease 2023 Feb;38(2):699-708
Porous composite hydrogels with improved MSC survival for robust epithelial sealing around implants and M2 macrophage polarization.
Li Y, Zhang J, Wang C, Jiang Z, Lai K, Wang Y, Yang G
Acta biomaterialia 2023 Feb;157:108-123
Acta biomaterialia 2023 Feb;157:108-123
Matrix metalloproteinase-21 promotes metastasis via increasing the recruitment and M2 polarization of macrophages in HCC.
Zhou J, Liu L, Hu X, Feng R, Zhao N, Zhang L, Hu W, Zhang J, Huang S, Liu L, Li W, Shan Y, Jin J
Cancer science 2023 Feb;114(2):423-435
Cancer science 2023 Feb;114(2):423-435
T cell-mediated targeted delivery of tadalafil regulates immunosuppression and polyamine metabolism to overcome immune checkpoint blockade resistance in hepatocellular carcinoma.
Wang X, Zhang Q, Zhou J, Xiao Z, Liu J, Deng S, Hong X, Huang W, Cai M, Guo Y, Huang J, Wang Y, Lin L, Zhu K
Journal for immunotherapy of cancer 2023 Feb;11(2)
Journal for immunotherapy of cancer 2023 Feb;11(2)
A novel transgenic mouse model expressing primate-specific nuclear choline acetyltransferase: insights into potential cholinergic vulnerability.
AlQot HE, Rylett RJ
Scientific reports 2023 Feb 21;13(1):3037
Scientific reports 2023 Feb 21;13(1):3037
Betulinic Acid Inhibits the Stemness of Gastric Cancer Cells by Regulating the GRP78-TGF-β1 Signaling Pathway and Macrophage Polarization.
Chen JL, Tai YS, Tsai HY, Hsieh CY, Chen CL, Liu CJ, Wu DC, Huang YB, Lin MW
Molecules (Basel, Switzerland) 2023 Feb 11;28(4)
Molecules (Basel, Switzerland) 2023 Feb 11;28(4)
Quercetin improves cerebral ischemia/reperfusion injury by promoting microglia/macrophages M2 polarization via regulating PI3K/Akt/NF-κB signaling pathway.
Li L, Jiang W, Yu B, Liang H, Mao S, Hu X, Feng Y, Xu J, Chu L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115653
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115653
Multi-omics analysis reveals the mechanism of action of ophiopogonin D against pulmonary fibrosis.
Bao S, Chen T, Chen J, Zhang J, Zhang G, Hui Y, Li J, Yan S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155078
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155078
MiR-223-3p attenuates M1 macrophage polarization via suppressing the Notch signaling pathway and NLRP3-mediated pyroptosis in experimental autoimmune uveitis.
Qu R, Peng Y, Zhou M, Xu S, Yin X, Qiu Y, Liu B, Gao Y, Bi H, Guo D
European journal of pharmacology 2023 Dec 5;960:176139
European journal of pharmacology 2023 Dec 5;960:176139
Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization.
Shen T, Lin R, Hu C, Yu D, Ren C, Li T, Zhu M, Wan Z, Su T, Wu Y, Cai W, Yu J
Journal of neuroinflammation 2023 Dec 21;20(1):308
Journal of neuroinflammation 2023 Dec 21;20(1):308
GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway.
Bao H, Peng Z, Cheng X, Jian C, Li X, Shi Y, Zhu W, Hu Y, Jiang M, Song J, Fang F, Chen J, Shu X
Journal of experimental & clinical cancer research : CR 2023 Dec 18;42(1):344
Journal of experimental & clinical cancer research : CR 2023 Dec 18;42(1):344
Neuron-Derived Exosomes Promote the Recovery of Spinal Cord Injury by Modulating Nerve Cells in the Cellular Microenvironment of the Lesion Area.
Xu Y, Zhu ZH, Xu X, Sun HT, Zheng HM, Zhang JL, Wang HH, Fang JW, Liu YZ, Huang LL, Song ZW, Liu JB
Molecular neurobiology 2023 Aug;60(8):4502-4516
Molecular neurobiology 2023 Aug;60(8):4502-4516
Synergistic effects of lipopolysaccharide and rotenone on dopamine neuronal damage in rats.
He JY, Li DD, Wen Q, Qin TY, Long H, Zhang SB, Zhang F
CNS neuroscience & therapeutics 2023 Aug;29(8):2281-2291
CNS neuroscience & therapeutics 2023 Aug;29(8):2281-2291
The ALOX5 inhibitor Zileuton regulates tumor-associated macrophage M2 polarization by JAK/STAT and inhibits pancreatic cancer invasion and metastasis.
Hu WM, Liu SQ, Zhu KF, Li W, Yang ZJ, Yang Q, Zhu ZC, Chang J
International immunopharmacology 2023 Aug;121:110505
International immunopharmacology 2023 Aug;121:110505
Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.
Tian J, Zhang L, La X, Fan X, Li A, Wu C, An Y, Yan S, Dong X, Wu H, Li Z
Cellular signalling 2023 Aug;108:110719
Cellular signalling 2023 Aug;108:110719
Arginase 1 and L-arginine coordinate fetal lung development and the initiation of labor in mice.
Yu Y, Liu Y, Sui X, Sui Y, Wang Z, Mendelson CR, Gao L
EMBO reports 2023 Aug 3;24(8):e56352
EMBO reports 2023 Aug 3;24(8):e56352
Exploring the mechanism of luteolin by regulating microglia polarization based on network pharmacology and in vitro experiments.
Wang T, Yin Y, Jiang X, Ruan Y, Xu J, Hu X, Li T, Chu L, Li L
Scientific reports 2023 Aug 23;13(1):13767
Scientific reports 2023 Aug 23;13(1):13767
p53 inhibits the Urea cycle and represses polyamine biosynthesis in glioma cell lines.
Zhao Y, Chen Y, Wei L, Ran J, Wang K, Zhu S, Liu Q
Metabolic brain disease 2023 Apr;38(4):1143-1153
Metabolic brain disease 2023 Apr;38(4):1143-1153
Functional characterization of interleukin 4 and retinoic acid signaling crosstalk during alternative macrophage activation.
Pinos I, Yu J, Pilli N, Kane MA, Amengual J
Biochimica et biophysica acta. Molecular and cell biology of lipids 2023 Apr;1868(4):159291
Biochimica et biophysica acta. Molecular and cell biology of lipids 2023 Apr;1868(4):159291
Spliceosomal GTPase Eftud2 regulates microglial activation and polarization.
Yang GC, Shi Y, Fan CN, Li Y, Yuan MQ, Pei J, Wu Y, Wu HT
Neural regeneration research 2023 Apr;18(4):856-862
Neural regeneration research 2023 Apr;18(4):856-862
Vagus nerve stimulation is a potential treatment for ischemic stroke.
Liu YL, Wang SR, Ma JX, Yu LH, Jia GW
Neural regeneration research 2023 Apr;18(4):825-831
Neural regeneration research 2023 Apr;18(4):825-831
Human placental extract regulates polarization of macrophages via IRGM/NLRP3 in allergic rhinitis.
Wo B, Du C, Yang Y, Qi H, Liang Z, He C, Yao F, Li X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114363
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114363
Wei-Tong-Xin exerts anti-inflammatory effects through TLR4-mediated macrophages M1/M2 polarization and affects GLP-1 secretion.
Zhang X, Yang X, Zhang S, Wang J, Wang M, Ma T, Wan M, Lv X, Yan T, Jia Y
The Journal of pharmacy and pharmacology 2023 Apr 7;75(4):574-584
The Journal of pharmacy and pharmacology 2023 Apr 7;75(4):574-584
Berberine mitigates intracerebral hemorrhage-induced neuroinflammation in a gut microbiota-dependent manner in mice.
Liu J, Chen H, Yu T, Fu X, Qian C, Feng X
Aging 2023 Apr 7;15(7):2705-2720
Aging 2023 Apr 7;15(7):2705-2720
Analysis and verification of the circRNA regulatory network RNO_CIRCpedia_ 4214/RNO-miR-667-5p/Msr1 axis as a potential ceRNA promoting macrophage M2-like polarization in spinal cord injury.
Cao J, Pan C, Zhang J, Chen Q, Li T, He D, Cheng X
BMC genomics 2023 Apr 5;24(1):181
BMC genomics 2023 Apr 5;24(1):181
Hypoxic ASCs-derived Exosomes Attenuate Colitis by Regulating Macrophage Polarization via miR-216a-5p/HMGB1 Axis.
Qian W, Huang L, Xu Y, Lu W, Wen W, Guo Z, Zhu W, Li Y
Inflammatory bowel diseases 2023 Apr 3;29(4):602-619
Inflammatory bowel diseases 2023 Apr 3;29(4):602-619
Regulatory Effects of Three-Dimensional Cultured Lipopolysaccharide-Pretreated Periodontal Ligament Stem Cell-Derived Secretome on Macrophages.
Su Y, Ai S, Shen Y, Cheng W, Xu C, Sui L, Zhao Y
International journal of molecular sciences 2023 Apr 10;24(8)
International journal of molecular sciences 2023 Apr 10;24(8)
SGLT2i alleviates epicardial adipose tissue inflammation by modulating ketone body-glyceraldehyde-3-phosphate dehydrogenase malonylation pathway.
Li L, Hua C, Liu X, Wang Y, Zhao L, Zhang Y, Wang L, Su P, Yang MF, Xie B
Journal of cardiovascular medicine (Hagerstown, Md.) 2023 Apr 1;24(4):232-243
Journal of cardiovascular medicine (Hagerstown, Md.) 2023 Apr 1;24(4):232-243
Macrophage Extracellular Traps Exacerbate Secondary Spinal Cord Injury by Modulating Macrophage/Microglia Polarization via LL37/P2X7R/NF-κB Signaling Pathway.
Zhang C, Guo D, Qiao H, Li J, Li J, Yang Y, Chang S, Li F, Wang D, Li H, He X, Wang F
Oxidative medicine and cellular longevity 2022;2022:9197940
Oxidative medicine and cellular longevity 2022;2022:9197940
In Vitro Immunomodulatory Effects of Inonotus obliquus Extracts on Resting M0 Macrophages and LPS-Induced M1 Macrophages.
Shen D, Feng Y, Zhang X, Liu J, Gong L, Liao H, Li R
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8251344
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8251344
Astragali Radix-Coptis Rhizoma Herb Pair Attenuates Atherosclerosis in ApoE-/- Mice by Regulating the M1/M2 and Th1/Th2 Immune Balance and Activating the STAT6 Signaling Pathway.
Li Z, Ma D, Wang Y, Wu S, Wang L, Jiang Y, Zhang Y, Li X
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7421265
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7421265
Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury.
Liu WZ, Ma ZJ, Kang JH, Lin AX, Wang ZH, Chen HW, Guo XD, He XG, Kang XW
Mediators of inflammation 2022;2022:2579003
Mediators of inflammation 2022;2022:2579003
Mesenchymal Stem Cells Improve Cognitive Impairment and Reduce Aβ Deposition via Promoting AQP4 Polarity and Relieving Neuroinflammation in Rats With Chronic Hypertension-Induced Cerebral Small-Vessel Disease.
Liu XL, Ouyang FB, Hu LT, Sun P, Yang J, Sun YJ, Liao MS, Lan LF, Pei Z, Fan YH
Frontiers in aging neuroscience 2022;14:883503
Frontiers in aging neuroscience 2022;14:883503
Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NF-κB/NLRP3 signaling pathway.
Li L, Deng S, Liu M, Yang M, Li J, Liu T, Zhang T, Zhao Y, He M, Wu D, Xu Y
Frontiers in pharmacology 2022;13:956402
Frontiers in pharmacology 2022;13:956402
Evaluation of an ImmunoPET Tracer for IL-12 in a Preclinical Model of Inflammatory Immune Responses.
Viola NT, Glassbrook JE, Kalluri JR, Hackett JB, Wicker MN, Sternberg J, Gibson HM
Frontiers in immunology 2022;13:870110
Frontiers in immunology 2022;13:870110
TRIM21 aggravates cardiac injury after myocardial infarction by promoting M1 macrophage polarization.
Li Z, Liu X, Zhang X, Zhang W, Gong M, Qin X, Luo J, Fang Y, Liu B, Wei Y
Frontiers in immunology 2022;13:1053171
Frontiers in immunology 2022;13:1053171
A multifunctional drug consisting of tetracycline conjugated with odanacatib for efficient periodontitis therapy.
Li D, Zhang W, Ye W, Liu Y, Li Y, Wang Y, Shi B, Zheng X, An Y, Ma Z, Hu K, Zhou H, Xue Y
Frontiers in pharmacology 2022;13:1046451
Frontiers in pharmacology 2022;13:1046451
Identification and validation of a 17-gene signature to improve the survival prediction of gliomas.
Tong S, Xia M, Xu Y, Sun Q, Ye L, Cai J, Ye Z, Tian D
Frontiers in immunology 2022;13:1000396
Frontiers in immunology 2022;13:1000396
Identification of the novel prognostic biomarker, MLLT11, reveals its relationship with immune checkpoint markers in glioma.
Chen L, Xiong Z, Zhao H, Teng C, Liu H, Huang Q, Wanggou S, Li X
Frontiers in oncology 2022;12:889351
Frontiers in oncology 2022;12:889351
Prognostic Value and Biological Function of Galectins in Malignant Glioma.
Zhu H, Liu D, Cheng L, Liu J, Wang G, Li H, Zhang Y, Mi H, Zhang S, Shu K, Yu X
Frontiers in oncology 2022;12:834307
Frontiers in oncology 2022;12:834307
CXCR3 antagonist AMG487 ameliorates experimental autoimmune prostatitis by diminishing Th1 cell differentiation and inhibiting macrophage M1 phenotypic activation.
Hua X, Zhang J, Ge S, Liu H, Du H, Niu Q, Chen X, Yang C, Zhang L, Liang C
The Prostate 2022 Sep;82(13):1223-1236
The Prostate 2022 Sep;82(13):1223-1236
Inhibition of Mer exacerbates early brain injury by regulating microglia/macrophage phenotype after subarachnoid hemorrhage in mice.
Tan X, Zheng Y, Zeng H, Peng Y, Yu X, Cao S
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2022 Sep;31(9):106659
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2022 Sep;31(9):106659
Vagus nerve stimulation promotes the M1-to-M2 transition via inhibition of TLR4/NF-κB in microglial to rescue the reperfusion injury.
Zhang L, Zhang X, Liu Y, Wang S, Jia G
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2022 Sep;31(9):106596
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2022 Sep;31(9):106596
Protective effects of budesonide on LPS-induced podocyte injury by modulating macrophage M1/M2 polarization: Evidence from in vitro and in silico studies.
Zhang X, Wang G, Shen D, Feng Y, Zhang Y, Zhang C, Li Y, Liao H
Experimental and therapeutic medicine 2022 Sep;24(3):589
Experimental and therapeutic medicine 2022 Sep;24(3):589
Mechanical stress protects against chondrocyte pyroptosis through lipoxin A(4) via synovial macrophage M2 subtype polarization in an osteoarthritis model.
Shen P, Jia S, Wang Y, Zhou X, Zhang D, Jin Z, Wang Z, Liu D, Bai L, Yang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113361
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113361
Structural damage to the rat eye following long-term simulated weightlessness.
Li S, Song Q, Wu B, Kan G, Wang F, Yang J, Zhu S
Experimental eye research 2022 Oct;223:109200
Experimental eye research 2022 Oct;223:109200
Maresin 1 enhances osteogenic potential of mesenchymal stem cells by modulating macrophage peroxisome proliferator-activated receptor-γ-mediated inflammation resolution.
Yao D, Zou Y, Lv Y
Biomaterials advances 2022 Oct;141:213116
Biomaterials advances 2022 Oct;141:213116
Injectable and reactive oxygen species-scavenging gelatin hydrogel promotes neural repair in experimental traumatic brain injury.
Zhang D, Chang R, Ren Y, He Y, Guo S, Guan F, Yao M
International journal of biological macromolecules 2022 Oct 31;219:844-863
International journal of biological macromolecules 2022 Oct 31;219:844-863
Peimine ameliorates pulmonary fibrosis via the inhibition of M2-type macrophage polarization through the suppression of P38/Akt/STAT6 signals.
Cai ZH, Tian YG, Li JZ, Zhao P, Li JS, Mei X, Bai YP
Bioscience reports 2022 Oct 28;42(10)
Bioscience reports 2022 Oct 28;42(10)
OIT3 mediates macrophage polarization and facilitates hepatocellular carcinoma progression.
Yang S, Zhang J, Xu Y, Wang J, Zhao H, Lei J, Zhou Y, Chen Y, Wu L, Zhou M, Zheng L, Ji X, Li Y
Cancer immunology, immunotherapy : CII 2022 Nov;71(11):2677-2689
Cancer immunology, immunotherapy : CII 2022 Nov;71(11):2677-2689
Schisandra chinensis Lignans Exert Antidepressant Effects by Promoting BV2 Microglia Polarization toward the M2 Phenotype through the Activation of the Cannabinoid Receptor Type-2-Signal Transducer and Activator of Transcription 6 Pathway.
Wang J, Zhang G, Yang Y, Zhang X, Shi K, Zhang X, Yan T, Jia Y
Journal of agricultural and food chemistry 2022 Nov 9;70(44):14157-14169
Journal of agricultural and food chemistry 2022 Nov 9;70(44):14157-14169
The Clostridium Metabolite P-Cresol Sulfate Relieves Inflammation of Primary Biliary Cholangitis by Regulating Kupffer Cells.
Fu HY, Xu JM, Ai X, Dang FT, Tan X, Yu HY, Feng J, Yang WX, Ma HT, Tu RF, Gupta AK, Manandhar LK, Bao WM, Tang YM
Cells 2022 Nov 26;11(23)
Cells 2022 Nov 26;11(23)
Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury.
Zhao R, Wang L, Wang T, Xian P, Wang H, Long Q
Journal of controlled release : official journal of the Controlled Release Society 2022 May;345:214-230
Journal of controlled release : official journal of the Controlled Release Society 2022 May;345:214-230
Urea transporter B downregulates polyamines levels in melanoma B16 cells via p53 activation.
Li J, Sun Y, Yan R, Wu X, Zou H, Meng Y
Biochimica et biophysica acta. Molecular cell research 2022 May;1869(5):119236
Biochimica et biophysica acta. Molecular cell research 2022 May;1869(5):119236
Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.
Head PE, Myung S, Chen Y, Schneller JL, Wang C, Duncan N, Hoffman P, Chang D, Gebremariam A, Gucek M, Manoli I, Venditti CP
Science translational medicine 2022 May 25;14(646):eabn4772
Science translational medicine 2022 May 25;14(646):eabn4772
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Kang H, Dong Y, Peng R, Liu H, Guo Q, Song K, Zhu M, Yu K, Wu W, Li F
Biochemical pharmacology 2022 Mar;197:114932
Biochemical pharmacology 2022 Mar;197:114932
Endothelial Shp2 deficiency controls alternative activation of macrophage preventing radiation-induced lung injury through notch signaling.
Liu P, Li Y, Li M, Zhou H, Zhang H, Zhang Y, Xu J, Xu Y, Zhang J, Xia B, Cheng H, Ke Y, Zhang X
iScience 2022 Mar 18;25(3):103867
iScience 2022 Mar 18;25(3):103867
Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages.
Gao T, Huang F, Wang W, Xie Y, Wang B
Cellular & molecular biology letters 2022 Mar 17;27(1):27
Cellular & molecular biology letters 2022 Mar 17;27(1):27
Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization.
Wang G, Li X, Li N, Wang X, He S, Li W, Fan W, Li R, Liu J, Hou S
Redox biology 2022 Jun;52:102297
Redox biology 2022 Jun;52:102297
Effects of ALA-PDT on the macrophages in wound healing and its related mechanisms in vivo and in vitro.
Li L, Yang Y, Yang Z, Zheng M, Luo G, He W, Yin R
Photodiagnosis and photodynamic therapy 2022 Jun;38:102816
Photodiagnosis and photodynamic therapy 2022 Jun;38:102816
Rutin Inhibits Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation by Inducing Autophagy and Modulating PI3K/ATK Signaling.
Li B, Ji Y, Yi C, Wang X, Liu C, Wang C, Lu X, Xu X, Wang X
Molecules (Basel, Switzerland) 2022 Jun 29;27(13)
Molecules (Basel, Switzerland) 2022 Jun 29;27(13)
Implantation of a nerve protector embedded with human GMSC-derived Schwann-like cells accelerates regeneration of crush-injured rat sciatic nerves.
Zhang Q, Burrell JC, Zeng J, Motiwala FI, Shi S, Cullen DK, Le AD
Stem cell research & therapy 2022 Jun 20;13(1):263
Stem cell research & therapy 2022 Jun 20;13(1):263
Progranulin deficiency promotes persistent neuroinflammation and causes regional pathology in the hippocampus following traumatic brain injury.
Zheng X, Mi T, Wang R, Zhang Z, Li W, Zhao J, Yang P, Xia H, Mao Q
Glia 2022 Jul;70(7):1317-1336
Glia 2022 Jul;70(7):1317-1336
Epithelial‑derived exosomes promote M2 macrophage polarization via Notch2/SOCS1 during mechanical ventilation.
Wang Y, Xie W, Feng Y, Xu Z, He Y, Xiong Y, Chen L, Li X, Liu J, Liu G, Wu Q
International journal of molecular medicine 2022 Jul;50(1)
International journal of molecular medicine 2022 Jul;50(1)
Wharton's jelly mesenchymal stem cell-derived small extracellular vesicles as natural nanoparticles to attenuate cartilage injury via microRNA regulation.
Chen P, Tang S, Gao H, Zhang H, Chen C, Fang Z, Peng G, Weng H, Chen A, Zhang C, Qiu Z, Li S, Chen J, Chen L, Chen X
International journal of pharmaceutics 2022 Jul 25;623:121952
International journal of pharmaceutics 2022 Jul 25;623:121952
Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response.
Yang W, Tao K, Zhang P, Chen X, Sun X, Li R
Biochemical pharmacology 2022 Jan;195:114863
Biochemical pharmacology 2022 Jan;195:114863
Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment.
Wang L, Zhang D, Ren Y, Guo S, Li J, Ma S, Yao M, Guan F
Materials today. Bio 2022 Jan;13:100201
Materials today. Bio 2022 Jan;13:100201
Biomimetic manganese-eumelanin nanocomposites for combined hyperthermia-immunotherapy against prostate cancer.
Liu Y, Shang W, Liu H, Hui H, Wu J, Zhang W, Gao P, Guo K, Guo Y, Tian J
Journal of nanobiotechnology 2022 Jan 24;20(1):48
Journal of nanobiotechnology 2022 Jan 24;20(1):48
C1q inhibits differentiation of oligodendrocyte progenitor cells via Wnt/β-catenin signaling activation in a cuprizone-induced mouse model of multiple sclerosis.
Gao Z, Zhang C, Feng Z, Liu Z, Yang Y, Yang K, Chen L, Yao R
Experimental neurology 2022 Feb;348:113947
Experimental neurology 2022 Feb;348:113947
One-Step Synthesis of Multifunctional Chitosan Hydrogel for Full-Thickness Wound Closure and Healing.
Guo S, Yao M, Zhang D, He Y, Chang R, Ren Y, Guan F
Advanced healthcare materials 2022 Feb;11(4):e2101808
Advanced healthcare materials 2022 Feb;11(4):e2101808
miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression.
Ma C, He D, Tian P, Wang Y, He Y, Wu Q, Jia Z, Zhang X, Zhang P, Ying H, Jin ZB, Hu G
Proceedings of the National Academy of Sciences of the United States of America 2022 Feb 8;119(6)
Proceedings of the National Academy of Sciences of the United States of America 2022 Feb 8;119(6)
Myoglobin promotes macrophage polarization to M1 type and pyroptosis via the RIG-I/Caspase1/GSDMD signaling pathway in CS-AKI.
Li N, Chen J, Geng C, Wang X, Wang Y, Sun N, Wang P, Han L, Li Z, Fan H, Hou S, Gong Y
Cell death discovery 2022 Feb 28;8(1):90
Cell death discovery 2022 Feb 28;8(1):90
Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway.
Liang L, Liu L, Zhou W, Yang C, Mai G, Li H, Chen Y
Clinical science (London, England : 1979) 2022 Feb 25;136(4):291-307
Clinical science (London, England : 1979) 2022 Feb 25;136(4):291-307
Caffeine treatment started before injury reduces hypoxic-ischemic white-matter damage in neonatal rats by regulating phenotypic microglia polarization.
Yang L, Yu X, Zhang Y, Liu N, Xue X, Fu J
Pediatric research 2022 Dec;92(6):1543-1554
Pediatric research 2022 Dec;92(6):1543-1554
Exosomes derived from bone marrow mesenchymal stem cells inhibit neuroinflammation after traumatic brain injury.
Wen L, Wang YD, Shen DF, Zheng PD, Tu MD, You WD, Zhu YR, Wang H, Feng JF, Yang XF
Neural regeneration research 2022 Dec;17(12):2717-2724
Neural regeneration research 2022 Dec;17(12):2717-2724
GABA regulates IL-1β production in macrophages.
Fu J, Han Z, Wu Z, Xia Y, Yang G, Yin Y, Ren W
Cell reports 2022 Dec 6;41(10):111770
Cell reports 2022 Dec 6;41(10):111770
An SPM-Enriched Marine Oil Supplement Shifted Microglia Polarization toward M2, Ameliorating Retinal Degeneration in rd10 Mice.
Olivares-González L, Velasco S, Gallego I, Esteban-Medina M, Puras G, Loucera C, Martínez-Romero A, Peña-Chilet M, Pedraz JL, Rodrigo R
Antioxidants (Basel, Switzerland) 2022 Dec 30;12(1)
Antioxidants (Basel, Switzerland) 2022 Dec 30;12(1)
Overexpressed DDX3x promotes abdominal aortic aneurysm formation and activates AKT in ApoE knockout mice.
Zhou Y, Chai H, Hu Y, Liu R, Jiang H, Fan R, Chen W, Chen X, Huang F
Biochemical and biophysical research communications 2022 Dec 17;634:138-144
Biochemical and biophysical research communications 2022 Dec 17;634:138-144
Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes.
Cui L, Wang Y, Ren L, Li Z, Jiang Y, Wang C, Liu X, Ren Y, Hu X
Parasites & vectors 2022 Dec 13;15(1):464
Parasites & vectors 2022 Dec 13;15(1):464
Notoginsenoside R1-loaded mesoporous silica nanoparticles targeting the site of injury through inflammatory cells improves heart repair after myocardial infarction.
Li H, Zhu J, Xu YW, Mou FF, Shan XL, Wang QL, Liu BN, Ning K, Liu JJ, Wang YC, Mi JX, Wei X, Shao SJ, Cui GH, Lu R, Guo HD
Redox biology 2022 Aug;54:102384
Redox biology 2022 Aug;54:102384
A cell-free difunctional demineralized bone matrix scaffold enhances the recruitment and osteogenesis of mesenchymal stem cells by promoting inflammation resolution.
Yao D, Lv Y
Biomaterials advances 2022 Aug;139:213036
Biomaterials advances 2022 Aug;139:213036
MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization.
Zhang Y, Le X, Zheng S, Zhang K, He J, Liu M, Tu C, Rao W, Du H, Ouyang Y, Li C, Wu D
Stem cell research & therapy 2022 Apr 27;13(1):171
Stem cell research & therapy 2022 Apr 27;13(1):171
Urea as a By-Product of Ammonia Metabolism Can Be a Potential Serum Biomarker of Hepatocellular Carcinoma.
Bai C, Wang H, Dong D, Li T, Yu Z, Guo J, Zhou W, Li D, Yan R, Wang L, Wang Z, Li Y, Ren L
Frontiers in cell and developmental biology 2021;9:650748
Frontiers in cell and developmental biology 2021;9:650748
lncRNA Gm16410 Mediates PM(2).(5)-Induced Macrophage Activation via PI3K/AKT Pathway.
Xu J, Xu H, Ma K, Wang Y, Niu B, Zhang L, Li F
Frontiers in cell and developmental biology 2021;9:618045
Frontiers in cell and developmental biology 2021;9:618045
MCC950 Ameliorates Acute Liver Injury Through Modulating Macrophage Polarization and Myeloid-Derived Suppressor Cells Function.
Yan W, Shen Y, Huang J, Lu L, Zhang Q
Frontiers in medicine 2021;8:752223
Frontiers in medicine 2021;8:752223
Inhibition of Sphingosine-1-Phosphate Receptor 2 Prevents Thoracic Aortic Dissection and Rupture.
Pan G, Liao M, Dai Y, Li Y, Yan X, Mai W, Liu J, Liao Y, Qiu Z, Zhou Z
Frontiers in cardiovascular medicine 2021;8:748486
Frontiers in cardiovascular medicine 2021;8:748486
PAK1 Silencing Attenuated Proinflammatory Macrophage Activation and Foam Cell Formation by Increasing PPARγ Expression.
Cheng WL, Zhang Q, Li B, Cao JL, Jiao L, Chao SP, Lu Z, Zhao F
Oxidative medicine and cellular longevity 2021;2021:6957900
Oxidative medicine and cellular longevity 2021;2021:6957900
Sodium Lactate Accelerates M2 Macrophage Polarization and Improves Cardiac Function after Myocardial Infarction in Mice.
Zhang J, Huang F, Chen L, Li G, Lei W, Zhao J, Liao Y, Li Y, Li C, Chen M
Cardiovascular therapeutics 2021;2021:5530541
Cardiovascular therapeutics 2021;2021:5530541
The Effect of miR-520b on Macrophage Polarization and T Cell Immunity by Targeting PTEN in Breast Cancer.
Zhu Q, Yuan J, He Y, Hu Y
Journal of oncology 2021;2021:5170496
Journal of oncology 2021;2021:5170496
Metformin Alleviates Neuroinflammation Following Intracerebral Hemorrhage in Mice by Regulating Microglia/Macrophage Phenotype in a Gut Microbiota-Dependent Manner.
Yu X, Fu X, Wu X, Tang W, Xu L, Hu L, Xu C, Zhou H, Zhou G, Li J, Cao S, Liu J, Yan F, Wang L, Liu F, Chen G
Frontiers in cellular neuroscience 2021;15:789471
Frontiers in cellular neuroscience 2021;15:789471
A Novel Hydrogen Sulfide Donor Reduces Pilocarpine-Induced Status Epilepticus and Regulates Microglial Inflammatory Profile.
Liu Z, Zhu Z, He Y, Kang Q, Li F, Zhang W, He Y, Lin Y, Huang B, Mo M, Xu P, Zhu X
Frontiers in cellular neuroscience 2021;15:780447
Frontiers in cellular neuroscience 2021;15:780447
The Impact of β-1,4-Galactosyltransferase V on Microglial Function.
Wang X, Shi N, Hui M, Jin H, Gao S, Zhou Q, Zhang L, Yan M, Shen H
Frontiers in cellular neuroscience 2021;15:723308
Frontiers in cellular neuroscience 2021;15:723308
Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice.
Yang XB, Zu HB, Zhao YF, Yao K
Frontiers in aging neuroscience 2021;13:766410
Frontiers in aging neuroscience 2021;13:766410
β2-Adrenergic Receptor Enhances the Alternatively Activated Macrophages and Promotes Biliary Injuries Caused by Helminth Infection.
Koda S, Zhang B, Zhou QY, Xu N, Li J, Liu JX, Liu M, Lv ZY, Wang JL, Shi Y, Gao S, Yu Q, Li XY, Xu YH, Chen JX, Tekengne BOT, Adzika GK, Tang RX, Sun H, Zheng KY, Yan C
Frontiers in immunology 2021;12:754208
Frontiers in immunology 2021;12:754208
Loss of Diacylglycerol Kinase α Enhances Macrophage Responsiveness.
Manigat LC, Granade ME, Taori S, Miller CA, Vass LR, Zhong XP, Harris TE, Purow BW
Frontiers in immunology 2021;12:722469
Frontiers in immunology 2021;12:722469
PD-L1 Improves Motor Function and Alleviates Neuropathic Pain in Male Mice After Spinal Cord Injury by Inhibiting MAPK Pathway.
Kong F, Sun K, Zhu J, Li F, Lin F, Sun X, Luo X, Ren C, Lu L, Zhao S, Sun J, Wang Y, Shi J
Frontiers in immunology 2021;12:670646
Frontiers in immunology 2021;12:670646
Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation.
Horiuchi H, Parajuli B, Komiya H, Ogawa Y, Jin S, Takahashi K, Azuma YT, Tanaka F, Suzumura A, Takeuchi H
Frontiers in immunology 2021;12:615898
Frontiers in immunology 2021;12:615898
Suppressing Sart1 to modulate macrophage polarization by siRNA-loaded liposomes: a promising therapeutic strategy for pulmonary fibrosis.
Pan T, Zhou Q, Miao K, Zhang L, Wu G, Yu J, Xu Y, Xiong W, Li Y, Wang Y
Theranostics 2021;11(3):1192-1206
Theranostics 2021;11(3):1192-1206
Pseudomonas aeruginosa PcrV Enhances the Nitric Oxide-Mediated Tumoricidal Activity of Tumor-Associated Macrophages via a TLR4/PI3K/AKT/mTOR-Glycolysis-Nitric Oxide Circuit.
Yu H, Bai Y, Qiu J, He X, Xiong J, Dai Q, Wang X, Li Y, Sheng H, Xin R, Jiang L, Li Q, Li D, Zhang H, Zhang L, Chen Q, Peng J, Hu X, Zhang K
Frontiers in oncology 2021;11:736882
Frontiers in oncology 2021;11:736882
Colon-Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora.
Liu H, Cai Z, Wang F, Hong L, Deng L, Zhong J, Wang Z, Cui W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Sep;8(18):e2101619
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Sep;8(18):e2101619
Abdominal paracentesis drainage attenuates intestinal mucosal barrier damage through macrophage polarization in severe acute pancreatitis.
Yuan X, Luo C, Wu J, Li W, Guo X, Li S, Wang B, Sun H, Tang L
Experimental biology and medicine (Maywood, N.J.) 2021 Sep;246(18):2029-2038
Experimental biology and medicine (Maywood, N.J.) 2021 Sep;246(18):2029-2038
Matrix stiffness regulates bone repair by modulating 12-lipoxygenase-mediated early inflammation.
Yao D, Qiao F, Song C, Lv Y
Materials science & engineering. C, Materials for biological applications 2021 Sep;128:112359
Materials science & engineering. C, Materials for biological applications 2021 Sep;128:112359
Intracellular Sphingosine-1-Phosphate Receptor 3 Contributes to Lung Tumor Cell Proliferation.
Terlizzi M, Colarusso C, Ferraro G, Monti MC, Rosa I, Somma P, Salvi R, Pinto A, Sorrentino R
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2021 Sep 3;55(5):539-552
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2021 Sep 3;55(5):539-552
Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder.
Ma X, Qin C, Chen M, Yu HH, Chu YH, Chen TJ, Bosco DB, Wu LJ, Bu BT, Wang W, Tian DS
Journal of neuroinflammation 2021 Sep 15;18(1):201
Journal of neuroinflammation 2021 Sep 15;18(1):201
Ameliorative effects of miR-423-5p against polarization of microglial cells of the M1 phenotype by targeting a NLRP3 inflammasome signaling pathway.
Cheng J, Hao J, Jiang X, Ji J, Wu T, Chen X, Zhang F
International immunopharmacology 2021 Oct;99:108006
International immunopharmacology 2021 Oct;99:108006
Pharmacological Activation of RXR-α Promotes Hematoma Absorption via a PPAR-γ-dependent Pathway After Intracerebral Hemorrhage.
Xu C, Chen H, Zhou S, Sun C, Xia X, Peng Y, Zhuang J, Fu X, Zeng H, Zhou H, Cao Y, Yu Q, Li Y, Hu L, Zhou G, Yan F, Chen G, Li J
Neuroscience bulletin 2021 Oct;37(10):1412-1426
Neuroscience bulletin 2021 Oct;37(10):1412-1426
Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke.
Zhang L, Liu Y, Wang S, Long L, Zang Q, Ma J, Yu L, Jia G
Biochemical and biophysical research communications 2021 Nov 5;577:71-79
Biochemical and biophysical research communications 2021 Nov 5;577:71-79
The Protective Role of Yin-Yang 1 in Cardiac Injury and Remodeling After Myocardial Infarction.
Huang Y, Li L, Chen H, Liao Q, Yang X, Yang D, Xia X, Wang H, Wang WE, Chen L, Zeng C
Journal of the American Heart Association 2021 Nov 2;10(21):e021895
Journal of the American Heart Association 2021 Nov 2;10(21):e021895
Myeloid TBK1 Deficiency Induces Motor Deficits and Axon Degeneration Through Inflammatory Cell Infiltration.
Duan W, Yi L, Tian Y, Huang HP, Li Z, Bi Y, Guo M, Li Y, Liu Y, Ma Y, Song X, Liu Y, Li C
Molecular neurobiology 2021 May;58(5):2435-2446
Molecular neurobiology 2021 May;58(5):2435-2446
CSF1/CSF1R-mediated Crosstalk Between Choroidal Vascular Endothelial Cells and Macrophages Promotes Choroidal Neovascularization.
Zhou Y, Zeng J, Tu Y, Li L, Du S, Zhu L, Cang X, Lu J, Zhu M, Liu X
Investigative ophthalmology & visual science 2021 Mar 1;62(3):37
Investigative ophthalmology & visual science 2021 Mar 1;62(3):37
Loganin alleviates sepsis-induced acute lung injury by regulating macrophage polarization and inhibiting NLRP3 inflammasome activation.
Zhang J, Wang C, Wang H, Li X, Xu J, Yu K
International immunopharmacology 2021 Jun;95:107529
International immunopharmacology 2021 Jun;95:107529
A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.
Li J, Qin X, Shi J, Wang X, Li T, Xu M, Chen X, Zhao Y, Han J, Piao Y, Zhang W, Qu P, Wang L, Xiang R, Shi Y
eLife 2021 Jun 11;10
eLife 2021 Jun 11;10
Caloric restriction ameliorates high-fat diet induced cognitive deficits through attenuating neuroinflammation via the TREM2-PI3K/AKT signaling pathway.
Wang R, Zhou Z, Wang D, Zhao Q, Zhang C, Liu C, Zhao H, Yuan C, Yuan D, Wang T
Food & function 2021 Jul 21;12(14):6464-6478
Food & function 2021 Jul 21;12(14):6464-6478
Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-κB p65 mediated modulation of microglia polarization.
Fang M, Wan W, Li Q, Wan W, Long Y, Liu H, Yang X
Life sciences 2021 Jul 15;277:119567
Life sciences 2021 Jul 15;277:119567
Amniotic fluid-derived multipotent stromal cells drive diabetic wound healing through modulation of macrophages.
Subhan BS, Kwong J, Kuhn JF, Monas A, Sharma S, Rabbani PS
Journal of translational medicine 2021 Jan 6;19(1):16
Journal of translational medicine 2021 Jan 6;19(1):16
Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer.
Lu W, Yu W, He J, Liu W, Yang J, Lin X, Zhang Y, Wang X, Jiang W, Luo J, Zhang Q, Yang H, Peng S, Yi Z, Ren S, Chen J, Siwko S, Nussinov R, Cheng F, Zhang H, Liu M
EMBO molecular medicine 2021 Jan 11;13(1):e12798
EMBO molecular medicine 2021 Jan 11;13(1):e12798
Preventive and Therapeutic Spermidine Treatment Attenuates Acute Colitis in Mice.
Ma L, Ni L, Yang T, Mao P, Huang X, Luo Y, Jiang Z, Hu L, Zhao Y, Fu Z, Ni Y
Journal of agricultural and food chemistry 2021 Feb 17;69(6):1864-1876
Journal of agricultural and food chemistry 2021 Feb 17;69(6):1864-1876
Myeloid NEMO deficiency promotes tumor immunosuppression partly via MCP1-CCR2 axis.
Yuanyuan L, Yakun L, Zhongyao L, Le Y, Weisong D, Moran G, Hui B, Chunyan L
Experimental cell research 2021 Feb 15;399(2):112467
Experimental cell research 2021 Feb 15;399(2):112467
Schizandrin A ameliorates cognitive functions via modulating microglial polarisation in Alzheimer's disease mice.
Wang Q, Liu L, Guan H, Zhou Y, Li Q
Pharmaceutical biology 2021 Dec;59(1):860-867
Pharmaceutical biology 2021 Dec;59(1):860-867
Saponins from Panax japonicus attenuate cognitive impairment in ageing rats through regulating microglial polarisation and autophagy.
Pi XJ, Zhao QQ, Wang JX, Zhang XL, Yuan D, Hu SS, He YM, Zhang CC, Zhou ZY, Wang T
Pharmaceutical biology 2021 Dec;59(1):1117-1125
Pharmaceutical biology 2021 Dec;59(1):1117-1125
PLXNA2 knockdown promotes M2 microglia polarization through mTOR/STAT3 signaling to improve functional recovery in rats after cerebral ischemia/reperfusion injury.
Li S, Hua X, Zheng M, Wu J, Ma Z, Xing X, Ma J, Zhang J, Shan C, Xu J
Experimental neurology 2021 Dec;346:113854
Experimental neurology 2021 Dec;346:113854
Curcumin protects human umbilical vein endothelial cells against high oxidized low density lipoprotein-induced lipotoxicity and modulates autophagy.
Zhao L, Luo R, Yu H, Li S, Yu Q, Wang W, Cai K, Xu T, Chen R, Tian W
Iranian journal of basic medical sciences 2021 Dec;24(12):1734-1742
Iranian journal of basic medical sciences 2021 Dec;24(12):1734-1742
The glycolysis inhibitor 2-deoxyglucose ameliorates adjuvant-induced arthritis by regulating macrophage polarization in an AMPK-dependent manner.
Cai W, Cheng J, Zong S, Yu Y, Wang Y, Song Y, He R, Yuan S, Chen T, Hu M, Pan Y, Ma R, Liu H, Wei F
Molecular immunology 2021 Dec;140:186-195
Molecular immunology 2021 Dec;140:186-195
Inhibition of Dectin-1 Ameliorates Neuroinflammation by Regulating Microglia/Macrophage Phenotype After Intracerebral Hemorrhage in Mice.
Fu X, Zeng H, Zhao J, Zhou G, Zhou H, Zhuang J, Xu C, Li J, Peng Y, Cao Y, Li Y, Chen H, Wang L, Yan F, Chen G
Translational stroke research 2021 Dec;12(6):1018-1034
Translational stroke research 2021 Dec;12(6):1018-1034
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
Zhao P, Cai Z, Tian Y, Li J, Li K, Li M, Bai Y, Li J
International immunopharmacology 2021 Dec;101(Pt B):108360
International immunopharmacology 2021 Dec;101(Pt B):108360
Probiotic Bacillus cereus Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice through Improvement of the Intestinal Barrier Function, Anti-Inflammation, and Gut Microbiota Modulation.
Sheng K, Xu Y, Kong X, Wang J, Zha X, Wang Y
Journal of agricultural and food chemistry 2021 Dec 15;69(49):14810-14823
Journal of agricultural and food chemistry 2021 Dec 15;69(49):14810-14823
FNDC5 induces M2 macrophage polarization and promotes hepatocellular carcinoma cell growth by affecting the PPARγ/NF-κB/NLRP3 pathway.
Liu H, Wang M, Jin Z, Sun D, Zhu T, Liu X, Tan X, Shi G
Biochemical and biophysical research communications 2021 Dec 10;582:77-85
Biochemical and biophysical research communications 2021 Dec 10;582:77-85
LncRNA LINC01088 inhibits the function of trophoblast cells, activates the MAPK-signaling pathway and associates with recurrent pregnancy loss.
Zhao H, Li Y, Dong N, Zhang L, Chen X, Mao H, Al-Ameri SAA, Wang X, Wang Q, Du L, Wang C, Mao H
Molecular human reproduction 2021 Aug 7;27(8)
Molecular human reproduction 2021 Aug 7;27(8)
Inhibition of P2X4R attenuates white matter injury in mice after intracerebral hemorrhage by regulating microglial phenotypes.
Fu X, Zhou G, Wu X, Xu C, Zhou H, Zhuang J, Peng Y, Cao Y, Zeng H, Li Y, Li J, Gao L, Chen G, Wang L, Yan F
Journal of neuroinflammation 2021 Aug 23;18(1):184
Journal of neuroinflammation 2021 Aug 23;18(1):184
Simvastatin Enhances Muscle Regeneration Through Autophagic Defect-Mediated Inflammation and mTOR Activation in G93ASOD1 Mice.
Wang Y, Bai L, Li S, Wen Y, Liu Q, Li R, Liu Y
Molecular neurobiology 2021 Apr;58(4):1593-1606
Molecular neurobiology 2021 Apr;58(4):1593-1606
Distinct phenotypic expression levels of macrophages in neonatal lungs.
Fang SY, Chen JL, Chiu MH, Huang CC, Lin MW, Lam CF
Experimental and therapeutic medicine 2021 Apr;21(4):369
Experimental and therapeutic medicine 2021 Apr;21(4):369
M2 Macrophage-Derived Exosomal miR-590-3p Attenuates DSS-Induced Mucosal Damage and Promotes Epithelial Repair via the LATS1/YAP/ β-Catenin Signalling Axis.
Deng F, Yan J, Lu J, Luo M, Xia P, Liu S, Wang X, Zhi F, Liu D
Journal of Crohn's & colitis 2021 Apr 6;15(4):665-677
Journal of Crohn's & colitis 2021 Apr 6;15(4):665-677
Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer's Disease.
Li L, Li L, Zhang J, Huang S, Liu W, Wang Z, Liang S, Tao J, Chen L
Neural plasticity 2020;2020:8836173
Neural plasticity 2020;2020:8836173
Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson's Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo.
Feng CW, Chen NF, Chan TF, Chen WF
Parkinson's disease 2020;2020:8814236
Parkinson's disease 2020;2020:8814236
Hypothermia-Induced Ubiquitination of Voltage-Dependent Anion Channel 3 Protects BV2 Microglia Cells From Cytotoxicity Following Oxygen-Glucose Deprivation/Recovery.
Zhao S, Xiao P, Cui H, Gong P, Lin C, Chen F, Tang Z
Frontiers in molecular neuroscience 2020;13:100
Frontiers in molecular neuroscience 2020;13:100
Csf2 Attenuated Sepsis-Induced Acute Kidney Injury by Promoting Alternative Macrophage Transition.
Li Y, Zhai P, Zheng Y, Zhang J, Kellum JA, Peng Z
Frontiers in immunology 2020;11:1415
Frontiers in immunology 2020;11:1415
AhR activation attenuates calcium oxalate nephrocalcinosis by diminishing M1 macrophage polarization and promoting M2 macrophage polarization.
Yang X, Liu H, Ye T, Duan C, Lv P, Wu X, Liu J, Jiang K, Lu H, Yang H, Xia D, Peng E, Chen Z, Tang K, Ye Z
Theranostics 2020;10(26):12011-12025
Theranostics 2020;10(26):12011-12025
Sulforaphane elicts dual therapeutic effects on Renal Inflammatory Injury and crystal deposition in Calcium Oxalate Nephrocalcinosis.
Liu H, Yang X, Tang K, Ye T, Duan C, Lv P, Yan L, Wu X, Chen Z, Liu J, Deng Y, Zeng G, Xing J, Ye Z, Xu H
Theranostics 2020;10(16):7319-7334
Theranostics 2020;10(16):7319-7334
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
Zou G, Zhang X, Wang L, Li X, Xie T, Zhao J, Yan J, Wang L, Ye H, Jiao S, Xiang R, Shi Y
Theranostics 2020;10(15):6839-6853
Theranostics 2020;10(15):6839-6853
Fucoidan inhibits tooth movement by promoting restorative macrophage polarization through the STAT3 pathway.
Zhang S, Zhang H, Jin Z, Wang S, Wang Y, Zhu L, Sun W, Yan B
Journal of cellular physiology 2020 Sep;235(9):5938-5950
Journal of cellular physiology 2020 Sep;235(9):5938-5950
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
Kong H, Wang H, Zhuo Z, Li Z, Tian P, Wu J, Liu J, Chen Z, Zhang J, Luo Q
Laboratory investigation; a journal of technical methods and pathology 2020 Sep;100(9):1223-1237
Laboratory investigation; a journal of technical methods and pathology 2020 Sep;100(9):1223-1237
MG53 Protects hUC-MSCs against Inflammatory Damage and Synergistically Enhances Their Efficacy in Neuroinflammation Injured Brain through Inhibiting NLRP3/Caspase-1/IL-1β Axis.
Ma S, Wang Y, Zhou X, Li Z, Zhang Z, Wang Y, Huang T, Zhang Y, Shi J, Guan F
ACS chemical neuroscience 2020 Sep 2;11(17):2590-2601
ACS chemical neuroscience 2020 Sep 2;11(17):2590-2601
Anti-arthritis effect of berberine associated with regulating energy metabolism of macrophages through AMPK/ HIF-1α pathway.
Yu Y, Cai W, Zhou J, Lu H, Wang Y, Song Y, He R, Pei F, Wang X, Zhang R, Liu H, Wei F
International immunopharmacology 2020 Oct;87:106830
International immunopharmacology 2020 Oct;87:106830
A free-standing multilayer film as a novel delivery carrier of platelet lysates for potential wound-dressing applications.
Tang Q, Lim T, Wei XJ, Wang QY, Xu JC, Shen LY, Zhu ZZ, Zhang CQ
Biomaterials 2020 Oct;255:120138
Biomaterials 2020 Oct;255:120138
Ketogenic Diet Elicits Antitumor Properties through Inducing Oxidative Stress, Inhibiting MMP-9 Expression, and Rebalancing M1/M2 Tumor-Associated Macrophage Phenotype in a Mouse Model of Colon Cancer.
Zhang N, Liu C, Jin L, Zhang R, Wang T, Wang Q, Chen J, Yang F, Siebert HC, Zheng X
Journal of agricultural and food chemistry 2020 Oct 7;68(40):11182-11196
Journal of agricultural and food chemistry 2020 Oct 7;68(40):11182-11196
Blocking P2X7-Mediated Macrophage Polarization Overcomes Treatment Resistance in Lung Cancer.
Qin J, Zhang X, Tan B, Zhang S, Yin C, Xue Q, Zhang Z, Ren H, Chen J, Liu M, Qian M, Du B
Cancer immunology research 2020 Nov;8(11):1426-1439
Cancer immunology research 2020 Nov;8(11):1426-1439
Keratinocyte-Macrophage Crosstalk by the Nrf2/Ccl2/EGF Signaling Axis Orchestrates Tissue Repair.
Villarreal-Ponce A, Tiruneh MW, Lee J, Guerrero-Juarez CF, Kuhn J, David JA, Dammeyer K, Mc Kell R, Kwong J, Rabbani PS, Nie Q, Ceradini DJ
Cell reports 2020 Nov 24;33(8):108417
Cell reports 2020 Nov 24;33(8):108417
The effect of combining Endostar with radiotherapy on blood vessels, tumor-associated macrophages, and T cells in brain metastases of Lewis lung cancer.
Peng L, Wang Y, Fei S, Wei C, Tong F, Wu G, Ma H, Dong X
Translational lung cancer research 2020 Jun;9(3):745-760
Translational lung cancer research 2020 Jun;9(3):745-760
TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.
Wang Y, Zhang H, Chen Q, Jiao F, Shi C, Pei M, Lv J, Zhang H, Wang L, Gong Z
Cell proliferation 2020 Jun;53(6):e12829
Cell proliferation 2020 Jun;53(6):e12829
Functional changes of the liver in the absence of growth hormone (GH) action - Proteomic and metabolomic insights from a GH receptor deficient pig model.
Riedel EO, Hinrichs A, Kemter E, Dahlhoff M, Backman M, Rathkolb B, Prehn C, Adamski J, Renner S, Blutke A, de Angelis MH, Bidlingmaier M, Schopohl J, Arnold GJ, Fröhlich T, Wolf E
Molecular metabolism 2020 Jun;36:100978
Molecular metabolism 2020 Jun;36:100978
Relationship of tumour-associated macrophages with poor prognosis in Wilms' tumour.
Tian K, Wang X, Wu Y, Wu X, Du G, Liu W, Wu R
Journal of pediatric urology 2020 Jun;16(3):376.e1-376.e8
Journal of pediatric urology 2020 Jun;16(3):376.e1-376.e8
Beneficial Effects of Theta-Burst Transcranial Magnetic Stimulation on Stroke Injury via Improving Neuronal Microenvironment and Mitochondrial Integrity.
Zong X, Dong Y, Li Y, Yang L, Li Y, Yang B, Tucker L, Zhao N, Brann DW, Yan X, Hu S, Zhang Q
Translational stroke research 2020 Jun;11(3):450-467
Translational stroke research 2020 Jun;11(3):450-467
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Ma Z, Lu Y, Yang F, Li S, He X, Gao Y, Zhang G, Ren E, Wang Y, Kang X
Toxicology and applied pharmacology 2020 Jun 15;397:115014
Toxicology and applied pharmacology 2020 Jun 15;397:115014
An extracorporeal bioartificial liver embedded with 3D-layered human liver progenitor-like cells relieves acute liver failure in pigs.
Li WJ, Zhu XJ, Yuan TJ, Wang ZY, Bian ZQ, Jing HS, Shi X, Chen CY, Fu GB, Huang WJ, Shi YP, Liu Q, Zeng M, Zhang HD, Wu HP, Yu WF, Zhai B, Yan HX
Science translational medicine 2020 Jul 8;12(551)
Science translational medicine 2020 Jul 8;12(551)
SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α.
Zhang W, Dong Z, Xu M, Zhang S, Liu C, Chen S
Molecular metabolism 2020 Feb;32:85-96
Molecular metabolism 2020 Feb;32:85-96
Aminooxyacetic acid attenuates post-infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice.
Zhao P, Zhou W, Zhang Y, Li J, Zhao Y, Pan L, Shen Z, Chen W, Hui J
Journal of cellular and molecular medicine 2020 Feb;24(4):2593-2609
Journal of cellular and molecular medicine 2020 Feb;24(4):2593-2609
Analysis of Cyclooxygenase 2, Programmed Cell Death Ligand 1, and Arginase 1 Expression in Human Pituitary Adenoma.
Zhao G, Chen W, He J, Cui C, Zhao L, Zhao Y, Sun C, Nie D, Jin F, Kong L
World neurosurgery 2020 Dec;144:e660-e673
World neurosurgery 2020 Dec;144:e660-e673
Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization.
Zhang J, Rong Y, Luo C, Cui W
Aging 2020 Dec 22;12(24):25138-25152
Aging 2020 Dec 22;12(24):25138-25152
Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway.
Han X, Ma W, Zhu Y, Sun X, Liu N
Molecular and cellular endocrinology 2020 Aug 20;514:110878
Molecular and cellular endocrinology 2020 Aug 20;514:110878
An injectable recombinant human milk fat globule-epidermal growth factor 8-loaded copolymer system for spinal cord injury reduces inflammation through NF-κB and neuronal cell death.
Gong Z, Wang C, Ni L, Ying L, Shu J, Wang J, Yu C, Xia K, Cheng F, Shi K, Xu G, Yu Q, Shen J, Chen Q, Li F, Liang C
Cytotherapy 2020 Apr;22(4):193-203
Cytotherapy 2020 Apr;22(4):193-203
Alternatively activated macrophages are associated with the α2AP production that occurs with the development of dermal fibrosis : The role of alternatively activated macrophages on the development of fibrosis.
Kanno Y, Shu E, Niwa H, Kanoh H, Seishima M
Arthritis research & therapy 2020 Apr 10;22(1):76
Arthritis research & therapy 2020 Apr 10;22(1):76
Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation.
Shang W, Chen G, Li Y, Zhuo Y, Wang Y, Fang Z, Yu Y, Ren H
Journal of diabetes research 2019;2019:5641271
Journal of diabetes research 2019;2019:5641271
Suppressed androgen receptor expression promotes M2 macrophage reprogramming through the STAT3/SOCS3 pathway.
Ma W, Zhang J, Guo L, Wang Y, Lu S, Wang Z, Lu Q, Wei F
EXCLI journal 2019;18:21-29
EXCLI journal 2019;18:21-29
Myeloid-Derived Suppressor Cells and γδT17 Cells Contribute to the Development of Gastric MALT Lymphoma in H. felis-Infected Mice.
Zhao Y, Lu F, Ye J, Ji M, Pang Y, Wang Y, Wang L, Li G, Sun T, Li J, Ma D, Ji C
Frontiers in immunology 2019;10:3104
Frontiers in immunology 2019;10:3104
Role of Tim-3 in Decidual Macrophage Functional Polarization During Abnormal Pregnancy With Toxoplasma gondii Infection.
Zhang D, Ren L, Zhao M, Yang C, Liu X, Zhang H, Jiang Y, Sun X, Li T, Cui L, Hu X
Frontiers in immunology 2019;10:1550
Frontiers in immunology 2019;10:1550
Fusobacterium nucleatum Aggravates the Progression of Colitis by Regulating M1 Macrophage Polarization via AKT2 Pathway.
Liu L, Liang L, Liang H, Wang M, Lu B, Xue M, Deng J, Chen Y
Frontiers in immunology 2019;10:1324
Frontiers in immunology 2019;10:1324
Pancreatic cancer-educated macrophages protect cancer cells from complement-dependent cytotoxicity by up-regulation of CD59.
Zhang R, Liu Q, Peng J, Wang M, Gao X, Liao Q, Zhao Y
Cell death & disease 2019 Nov 4;10(11):836
Cell death & disease 2019 Nov 4;10(11):836
Macrophage polarization in periodontal ligament stem cells enhanced periodontal regeneration.
Liu J, Chen B, Bao J, Zhang Y, Lei L, Yan F
Stem cell research & therapy 2019 Nov 15;10(1):320
Stem cell research & therapy 2019 Nov 15;10(1):320
Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion.
Cao Y, Ding W, Zhang J, Gao Q, Yang H, Cao W, Wang Z, Fang L, Du R
Journal of proteome research 2019 May 3;18(5):2032-2044
Journal of proteome research 2019 May 3;18(5):2032-2044
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
Ma B, Cheng H, Mu C, Geng G, Zhao T, Luo Q, Ma K, Chang R, Liu Q, Gao R, Nie J, Xie J, Han J, Chen L, Ma G, Zhu Y, Chen Q
Nature communications 2019 Mar 4;10(1):1034
Nature communications 2019 Mar 4;10(1):1034
PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy.
Li Y, Zhou H, Li Y, Han L, Song M, Chen F, Shang G, Wang D, Wang Z, Zhang W, Zhong M
Journal of cellular and molecular medicine 2019 Jun;23(6):4179-4195
Journal of cellular and molecular medicine 2019 Jun;23(6):4179-4195
Berberine attenuates arthritis in adjuvant-induced arthritic rats associated with regulating polarization of macrophages through AMPK/NF-кB pathway.
Zhou J, Yu Y, Yang X, Wang Y, Song Y, Wang Q, Chen Z, Zong S, Fan M, Meng X, Xie C, Zhou F, Liu H, Wei F
European journal of pharmacology 2019 Jun 5;852:179-188
European journal of pharmacology 2019 Jun 5;852:179-188
Toxoplasma ROP16(I/III) ameliorated inflammatory bowel diseases via inducing M2 phenotype of macrophages.
Xu YW, Xing RX, Zhang WH, Li L, Wu Y, Hu J, Wang C, Luo QL, Shen JL, Chen X
World journal of gastroenterology 2019 Dec 7;25(45):6634-6652
World journal of gastroenterology 2019 Dec 7;25(45):6634-6652
Tandem Mass Tag Proteomic Analysis of in Vitro and in Vivo Models of Cutaneous Leishmaniasis Reveals Parasite-Specific and Nonspecific Modulation of Proteins in the Host.
Negrão F, Diedrich JK, Giorgio S, Eberlin MN, Yates JR 3rd
ACS infectious diseases 2019 Dec 13;5(12):2136-2147
ACS infectious diseases 2019 Dec 13;5(12):2136-2147
Metformin enhances gefitinib efficacy by interfering with interactions between tumor-associated macrophages and head and neck squamous cell carcinoma cells.
Yin X, Han S, Song C, Zou H, Wei Z, Xu W, Ran J, Tang C, Wang Y, Cai Y, Hu Q, Han W
Cellular oncology (Dordrecht, Netherlands) 2019 Aug;42(4):459-475
Cellular oncology (Dordrecht, Netherlands) 2019 Aug;42(4):459-475
Interleukin-1 receptor associated kinase (IRAK)-M -mediated type 2 microglia polarization ameliorates the severity of experimental autoimmune encephalomyelitis (EAE).
Liu B, Gu Y, Pei S, Peng Y, Chen J, Pham LV, Shen HY, Zhang J, Wang H
Journal of autoimmunity 2019 Aug;102:77-88
Journal of autoimmunity 2019 Aug;102:77-88
Comparative Proteomic Analysis of Murine Cutaneous Lesions Induced by Leishmania amazonensis or Leishmania major.
Negrão F, Giorgio S, Eberlin MN, Yates JR 3rd
ACS infectious diseases 2019 Aug 9;5(8):1295-1305
ACS infectious diseases 2019 Aug 9;5(8):1295-1305
Targeted Delivery of miRNA 155 to Tumor Associated Macrophages for Tumor Immunotherapy.
Zang X, Zhang X, Zhao X, Hu H, Qiao M, Deng Y, Chen D
Molecular pharmaceutics 2019 Apr 1;16(4):1714-1722
Molecular pharmaceutics 2019 Apr 1;16(4):1714-1722
Aryl Hydrocarbon Receptor Regulates Apoptosis and Inflammation in a Murine Model of Experimental Autoimmune Uveitis.
Huang Y, He J, Liang H, Hu K, Jiang S, Yang L, Mei S, Zhu X, Yu J, Kijlstra A, Yang P, Hou S
Frontiers in immunology 2018;9:1713
Frontiers in immunology 2018;9:1713
Effective Amelioration of Liver Fibrosis Through Lentiviral Vector Carrying Toxoplasma gondii gra15(II) in Murine Model.
Liu L, Jin M, Tao Q, Yu L, Du J, Wang C, Luo Q, Xing T, Xu Y, Shen J, Chu D
Frontiers in immunology 2018;9:1572
Frontiers in immunology 2018;9:1572
The Role of Alpha-Lipoic Acid in the Pathomechanism of Acute Ischemic Stroke.
Wang Q, Lv C, Sun Y, Han X, Wang S, Mao Z, Xin Y, Zhang B
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(1):42-53
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(1):42-53
Rapamycin and FTY720 Alleviate Atherosclerosis by Cross Talk of Macrophage Polarization and Autophagy.
Sun RZ, Fan Y, Liang X, Gong TT, Wang Q, Liu H, Shan ZY, Lei L
BioMed research international 2018;2018:1010248
BioMed research international 2018;2018:1010248
Targeting MAPK Pathways by Naringenin Modulates Microglia M1/M2 Polarization in Lipopolysaccharide-Stimulated Cultures.
Zhang B, Wei YZ, Wang GQ, Li DD, Shi JS, Zhang F
Frontiers in cellular neuroscience 2018;12:531
Frontiers in cellular neuroscience 2018;12:531
Clemastine Alleviates Depressive-Like Behavior Through Reversing the Imbalance of Microglia-Related Pro-inflammatory State in Mouse Hippocampus.
Su WJ, Zhang T, Jiang CL, Wang W
Frontiers in cellular neuroscience 2018;12:412
Frontiers in cellular neuroscience 2018;12:412
S100A8/A9 induces microglia activation and promotes the apoptosis of oligodendrocyte precursor cells by activating the NF-κB signaling pathway.
Wu M, Xu L, Wang Y, Zhou N, Zhen F, Zhang Y, Qu X, Fan H, Liu S, Chen Y, Yao R
Brain research bulletin 2018 Oct;143:234-245
Brain research bulletin 2018 Oct;143:234-245
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Liang M, Wang Z, Li H, Cai L, Pan J, He H, Wu Q, Tang Y, Ma J, Yang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
ER-localized protein-Herpud1 is a new mediator of IL-4-induced macrophage polarization and migration.
Li Y, Xie Y, Hao J, Liu J, Ning Y, Tang Q, Ma M, Zhou H, Guan S, Zhou Q, Lv X
Experimental cell research 2018 Jul 15;368(2):167-173
Experimental cell research 2018 Jul 15;368(2):167-173
Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells.
Yang L, Tucker D, Dong Y, Wu C, Lu Y, Li Y, Zhang J, Liu TC, Zhang Q
Experimental neurology 2018 Jan;299(Pt A):86-96
Experimental neurology 2018 Jan;299(Pt A):86-96
Interleukin-33 Protects Ischemic Brain Injury by Regulating Specific Microglial Activities.
Luo Q, Fan Y, Lin L, Wei J, Li Z, Li Y, Nakae S, Lin W, Chen Q
Neuroscience 2018 Aug 10;385:75-89
Neuroscience 2018 Aug 10;385:75-89
Treadmill Exercise Exerts Neuroprotection and Regulates Microglial Polarization and Oxidative Stress in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer's Disease.
Lu Y, Dong Y, Tucker D, Wang R, Ahmed ME, Brann D, Zhang Q
Journal of Alzheimer's disease : JAD 2017;56(4):1469-1484
Journal of Alzheimer's disease : JAD 2017;56(4):1469-1484
GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages.
Zhang L, Li Z, Ding G, La X, Yang P, Li Z
Cellular signalling 2017 Sep;37:136-148
Cellular signalling 2017 Sep;37:136-148
Matrine promotes NT3 expression in CNS cells in experimental autoimmune encephalomyelitis.
Zhang ML, Zhang XJ, Kang J, Zhang HJ, Chen XL, Liu N, Liu SQ, Ma WD, Zhang GX, Zhu L
Neuroscience letters 2017 May 10;649:100-106
Neuroscience letters 2017 May 10;649:100-106
Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model.
Bichell TJV, Wegrzynowicz M, Tipps KG, Bradley EM, Uhouse MA, Bryan M, Horning K, Fisher N, Dudek K, Halbesma T, Umashanker P, Stubbs AD, Holt HK, Kwakye GF, Tidball AM, Colbran RJ, Aschner M, Neely MD, Di Pardo A, Maglione V, Osmand A, Bowman AB
Biochimica et biophysica acta. Molecular basis of disease 2017 Jun;1863(6):1596-1604
Biochimica et biophysica acta. Molecular basis of disease 2017 Jun;1863(6):1596-1604
Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion.
Xia CY, Zhang S, Chu SF, Wang ZZ, Song XY, Zuo W, Gao Y, Yang PF, Chen NH
International immunopharmacology 2016 Oct;39:140-148
International immunopharmacology 2016 Oct;39:140-148
Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis.
Shimojima C, Takeuchi H, Jin S, Parajuli B, Hattori H, Suzumura A, Hibi H, Ueda M, Yamamoto A
Journal of immunology (Baltimore, Md. : 1950) 2016 May 15;196(10):4164-71
Journal of immunology (Baltimore, Md. : 1950) 2016 May 15;196(10):4164-71
A(H1N1) vaccination recruits T lymphocytes to the choroid plexus for the promotion of hippocampal neurogenesis and working memory in pregnant mice.
Qi F, Yang J, Xia Y, Yuan Q, Guo K, Zou J, Yao Z
Brain, behavior, and immunity 2016 Mar;53:72-83
Brain, behavior, and immunity 2016 Mar;53:72-83
Neonatal BCG vaccination of mice improves neurogenesis and behavior in early life.
Yang J, Qi F, Gu H, Zou J, Yang Y, Yuan Q, Yao Z
Brain research bulletin 2016 Jan;120:25-33
Brain research bulletin 2016 Jan;120:25-33
Effects of IL-4 on pulmonary fibrosis and the accumulation and phenotype of macrophage subpopulations following thoracic irradiation.
Groves AM, Johnston CJ, Misra RS, Williams JP, Finkelstein JN
International journal of radiation biology 2016 Dec;92(12):754-765
International journal of radiation biology 2016 Dec;92(12):754-765
M2 Polarization of Monocytes-Macrophages Is a Hallmark of Indian Post Kala-Azar Dermal Leishmaniasis.
Mukhopadhyay D, Mukherjee S, Roy S, Dalton JE, Kundu S, Sarkar A, Das NK, Kaye PM, Chatterjee M
PLoS neglected tropical diseases 2015 Oct;9(10):e0004145
PLoS neglected tropical diseases 2015 Oct;9(10):e0004145
Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors.
Iida M, Katsuno M, Nakatsuji H, Adachi H, Kondo N, Miyazaki Y, Tohnai G, Ikenaka K, Watanabe H, Yamamoto M, Kishida K, Sobue G
Human molecular genetics 2015 Jan 15;24(2):314-29
Human molecular genetics 2015 Jan 15;24(2):314-29
Ethanol supports macrophage recruitment and reinforces invasion and migration of Lewis lung carcinoma.
Yu K, Yang J, Wang F, Chen L, Lu Y, Luo J, Wang S
Alcoholism, clinical and experimental research 2014 Oct;38(10):2597-606
Alcoholism, clinical and experimental research 2014 Oct;38(10):2597-606
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human colon tissue were subjected to SDS PAGE followed by western blot with 16001-1-AP(ARG1 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The liver Arginase antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human liver Arginase. This antibody recognizes human,mouse,rat antigen. The liver Arginase antibody has been validated for the following applications: ELISA, WB, IHC, IP, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-ARG1 (IP:16001-1-AP, 3ug; Detection:16001-1-AP 1:1000) with mouse liver tissue lysate 12500ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 16001-1-AP(ARG1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 16001-1-AP(ARG1 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
