Antibody data

Product number
678801 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#678801, RRID:AB_2566050
Product name
Purified anti-Arginase I
Antibody type
Monoclonal
Antigen
Full length recombinant human ARG1 protein produced in HEK293T cells.
Description
ARG1 (Arginase 1), is a marker for the M2 anti-inflammatory macrophage subset that hydrolyzes l-arginine into urea and ornithine, and plays an important role in wound healing, antiviral immune responses, and atherosclerosis. The inherited deficiency of this enzyme results in argininemia, which is an autosomal recessive disorder characterized by hyperammonemia. Recent studies show that intracellular pathogens induce the expression of ARG1 in mouse macrophages through the Toll-like receptor (TLR) pathway. The deletion of this enzyme in macrophages favors host survival. Other studies indicate that ARG1 also plays a role in T cell responses and selective antagonists of ARG1 might prove beneficial in fighting diseases in which T-cell responses are inappropriately suppressed.
Reactivity
Human, Mouse
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
O94E6/ARG1
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
ARG1 protein structure - 678801 shown in red.