- HPA003595 - Atlas Antibodies ARG1 antibody

Submitted references Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity.

Yang J, Gonon AT, Sjöquist PO, Lundberg JO, Pernow J
Proceedings of the National Academy of Sciences of the United States of America 2013 Sep 10;110(37):15049-54

Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production.

Gonon AT, Jung C, Katz A, Westerblad H, Shemyakin A, Sjöquist PO, Lundberg JO, Pernow J
PloS one 2012;7(7):e42038

Arginase Inhibition Improves Endothelial Function in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus

Shemyakin A, Kovamees O, Rafnsson A, Bohm F, Svenarud P, Settergren M, Jung C, Pernow J
Circulation 2012 December;126(25):2943-2950

Arginase inhibition restores in vivo coronary microvascular function in type 2 diabetic rats

Gronros J, Jung C, Lundberg J, Cerrato R, Ostenson C, Pernow J
AJP: Heart and Circulatory Physiology 2011 March;300(4)

Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms.

Yan BC, Gong C, Song J, Krausz T, Tretiakova M, Hyjek E, Al-Ahmadie H, Alves V, Xiao SY, Anders RA, Hart JA
The American journal of surgical pathology 2010 Aug;34(8):1147-54

A quantitative proteomic approach for identification of potential biomarkers in hepatocellular carcinoma.

Chaerkady R, Harsha HC, Nalli A, Gucek M, Vivekanandan P, Akhtar J, Cole RN, Simmers J, Schulick RD, Singh S, Torbenson M, Pandey A, Thuluvath PJ
Journal of proteome research 2008 Oct;7(10):4289-98

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Enhanced validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Independent antibody validation
Main image
Experimental details: Western blot analysis using Anti-ARG1 antibody HPA003595 (A) shows similar pattern to independent antibody HPA024006 (B).
Antibody #2 product nr: HPA024006
Antibody provider: Atlas Antibodies

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Enhanced validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human liver and kidney tissues using HPA003595 antibody. Corresponding ARG1 RNA-seq data are presented for the same tissues.
Sample type: HUMAN
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human liver shows strong cytoplasmic and nuclear positivity in hepatocytes.
Sample type: HUMAN

Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human bone marrow shows strong cytoplasmic and nuclear positivity in a subset of hematopoietic cells.
Sample type: HUMAN

Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human hepatocellular carcinoma shows moderate cytoplasmic and nuclear positivity in tumor cells.
Sample type: HUMAN

Supportive validation

Submitted by: Atlas Antibodies (provider)
Main image
Experimental details: Immunohistochemical staining of human kidney shows no positivity in cells in tubules as expected.
Sample type: HUMAN

HPA003595

Antibody data