Antibody data
- Antibody Data
- Antigen structure
- References [77]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
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- Product number
- 66129-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- Arginase-1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated Arginase-1 antibody (Cat. #66129-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, pig, rat, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 5D6D12
- Vial size
- 20ul, 150ul
Submitted references Myeloid Deletion of Cdc42 Protects Liver From Hepatic Ischemia-Reperfusion Injury via Inhibiting Macrophage-Mediated Inflammation in Mice.
Inhibition of PTEN promotes osteointegration of titanium implants in type 2 diabetes by enhancing anti-inflammation and osteogenic capacity of adipose-derived stem cells.
Crystalline silica-induced endoplasmic reticulum stress promotes the pathogenesis of silicosis by augmenting proinflammatory interstitial pulmonary macrophages.
Gastrodin Regulates PI3K/AKT-Sirt3 Signaling Pathway and Proinflammatory Mediators in Activated Microglia.
Effect of CTLA-4 Inhibition on Inflammation and Apoptosis After Spinal Cord Injury.
Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction.
Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.
Photothermal and Photocatalytic Glycol Chitosan and Polydopamine-Grafted Oxygen Vacancy Bismuth Oxyiodide (BiO(1-x) I) Nanoparticles for the Diagnosis and Targeted Therapy of Diabetic Wounds.
The Effect of Salvianolic Acid A on Tumor-Associated Macrophage Polarization and Its Mechanisms in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Human amniotic MSCs-mediated anti-inflammation of CD206(hi)IL-10(hi) macrophages alleviates isoproterenol-induced ventricular remodeling in mice.
Astragaloside IV alleviates macrophage senescence and d-galactose-induced bone loss in mice through STING/NF-κB pathway.
Laminin-derived peptide, IKVAV, modulates macrophage phenotype through integrin mediation.
Multifunctional Biodegradable Conductive Hydrogel Regulating Microenvironment for Stem Cell Therapy Enhances the Nerve Tissue Repair.
Prednisone combined with Dihydroartemisinin attenuates systemic lupus erythematosus by regulating M1/M2 balance through the MAPK signaling pathway.
Exosome/antimicrobial peptide laden hydrogel wound dressings promote scarless wound healing through miR-21-5p-mediated multiple functions.
Injectable, Electroconductive, Free Radical Scavenging Silk Fibroin/Black Phosphorus/Glycyrrhizic Acid Nanocomposite Hydrogel for Enhancing Spinal Cord Repair.
Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1.
Extract of Astragali Radix and Solanum nigrum Linne regulates microglia and macrophage polarization and inhibits the growth and infiltration of C6 glioblastoma.
Extracellular vesicles derived from monomeric α-synuclein-treated microglia ameliorate neuroinflammation by delivery of miRNAs targeting PRAK.
Moluodan promotes DSS-induced intestinal inflammation involving the reprogram of macrophage function and polarization.
S100A9 Induces Macrophage M2 Polarization and Immunomodulatory Role in the Lesion Site After Spinal Cord Injury in Rats.
Azithromycin regulates Mettl3-mediated NF-κB pathway to enhance M2 polarization of RAW264.7 macrophages and attenuate LPS-triggered cytotoxicity of MLE-12 alveolar cells.
Combined untargeted metabolomics and network pharmacology approaches to reveal the therapeutic role of withanolide B in psoriasis.
Investigation of anti-depression effects and potential mechanisms of the ethyl acetate extract of Cynomorium songaricum Rupr. through the integration of in vivo experiments, LC-MS/MS chemical analysis, and a systems biology approach.
BMP7 Attenuates Neuroinflammation after Spinal Cord Injury by Suppressing the Microglia Activation and Inducing Microglial Polarization Via the STAT3 Pathway.
Salidroside ameliorated the pulmonary inflammation induced by cigarette smoke via mitigating M1 macrophage polarization by JNK/c-Jun.
CD73 inhibits titanium particle-associated aseptic loosening by alternating activation of macrophages.
A multifunctional polydopamine/genipin/alendronate nanoparticle licences fibrin hydrogels osteoinductive and immunomodulatory potencies for repairing bone defects.
Critical contributions of protein cargos to the functions of macrophage-derived extracellular vesicles.
Gd-EOB MRI for HCC subtype differentiation in a western population according to the 5(th) edition of the World Health Organization classification.
Autophagy suppression facilitates macrophage M2 polarization via increased instability of NF-κB pathway in hepatocellular carcinoma.
Low-dose adropin stimulates inflammasome activation of macrophage via mitochondrial ROS involved in colorectal cancer progression.
Ultrasound-Induced Gold Nanoparticle United with Acoustic Reprogramming of Macrophages for Enhanced Cancer Therapy.
IGF2BP3 drives gallbladder cancer progression by m6A-modified CLDN4 and inducing macrophage immunosuppressive polarization.
Dauricine regulates prostate cancer progression by inhibiting PI3K/AKT-dependent M2 polarization of macrophages.
The metabolite butyrate produced by gut microbiota inhibits cachexia-associated skeletal muscle atrophy by regulating intestinal barrier function and macrophage polarization.
Garlic-derived exosomes carrying miR-396e shapes macrophage metabolic reprograming to mitigate the inflammatory response in obese adipose tissue.
Tongxinluo promotes endothelium-dependent arteriogenesis to attenuate diabetic peripheral arterial disease.
Lacticaseibacillus casei CNRZ1874 supplementation promotes M1 alveolar macrophage activation and attenuates Mycoplasma pneumoniae pneumonia.
Targeting of Annexin A1 in Tumor-associated Macrophages as a therapeutic strategy for hepatocellular carcinoma.
Selenium-Doped Mesoporous Bioactive Glass Regulates Macrophage Metabolism and Polarization by Scavenging ROS and Promotes Bone Regeneration In Vivo.
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.
Arthritic Microenvironment Actuated Nanomotors for Active Rheumatoid Arthritis Therapy.
FNDC5/Irisin Inhibits the Inflammatory Response and Mediates the Aerobic Exercise-Induced Improvement of Liver Injury after Myocardial Infarction.
Deferoxamine prevents poststroke memory impairment in female diabetic rats: potential links to hemorrhagic transformation and ferroptosis.
CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-κB pathway.
Neurovascular dysfunction associated with erectile dysfunction persists after long-term recovery from simulations of weightlessness and deep space irradiation.
The effects of astragaloside IV on gut microbiota and serum metabolism in a mice model of intracerebral hemorrhage.
Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization.
TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation.
CCL6 promotes M2 polarization and inhibits macrophage autophagy by activating PI3-kinase/Akt signalling pathway during skin wound healing.
Menstrual blood-derived endometrial stem cells alleviate neuroinflammation by modulating M1/M2 polarization in cell and rat Parkinson's disease models.
Exosomes Derived From M2 Microglia Cells Attenuates Neuronal Impairment and Mitochondrial Dysfunction in Alzheimer's Disease Through the PINK1/Parkin Pathway.
Exploration of the potential mechanism of Pushen capsule in the treatment of vascular dementia based on network pharmacology and experimental verification.
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats.
Neuroglobin alleviates the neurotoxicity of sevoflurane to fetal rats by inhibiting neuroinflammation and affecting microglial polarization.
Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway.
microRNA-155-3p delivered by M2 macrophages-derived exosomes enhances the progression of medulloblastoma through regulation of WDR82.
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
ALA-PDT regulates macrophage M1 polarization via ERK/MAPK-NLRP3 pathway to promote the early inflammatory response.
Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism.
Macrophage depletion blocks congenital SARM1-dependent neuropathy.
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Rosuvastatin Nanomicelles Target Neuroinflammation and Improve Neurological Deficit in a Mouse Model of Intracerebral Hemorrhage.
Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization.
The Cholinergic Anti-Inflammatory Pathway Attenuates the Development of Atherosclerosis in Apoe(-/-) Mice through Modulating Macrophage Functions.
Reactive astrocytes induced by 2-chloroethanol modulate microglia polarization through IL-1β, TNF-α, and iNOS upregulation.
The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization.
Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis.
Injectable Gelatin Hydrogel Suppresses Inflammation and Enhances Functional Recovery in a Mouse Model of Intracerebral Hemorrhage.
Neuroprotective Effect of Ketone Metabolism on Inhibiting Inflammatory Response by Regulating Macrophage Polarization After Acute Cervical Spinal Cord Injury in Rats.
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Intravenously Infusing the Secretome of Adipose-Derived Mesenchymal Stem Cells Ameliorates Neuroinflammation and Neurological Functioning After Traumatic Brain Injury.
Lipoxin A4 Regulates Lipopolysaccharide-Induced BV2 Microglial Activation and Differentiation via the Notch Signaling Pathway.
Effects of exposure of adult mice to multi-walled carbon nanotubes on the liver lipid metabolism of their offspring.
Involvement of JNK signaling in IL4-induced M2 macrophage polarization.
He J, Tang MY, Liu LX, Kong CX, Chen W, Wang L, Zhi SB, Sun HW, Huang YC, Chen GY, Xin HB, Deng KY
Cellular and molecular gastroenterology and hepatology 2024;17(6):965-981
Cellular and molecular gastroenterology and hepatology 2024;17(6):965-981
Inhibition of PTEN promotes osteointegration of titanium implants in type 2 diabetes by enhancing anti-inflammation and osteogenic capacity of adipose-derived stem cells.
Zhang G, Song S, Chen Z, Liu X, Zheng J, Wang Y, Chen X, Song Y
Frontiers in bioengineering and biotechnology 2024;12:1358802
Frontiers in bioengineering and biotechnology 2024;12:1358802
Crystalline silica-induced endoplasmic reticulum stress promotes the pathogenesis of silicosis by augmenting proinflammatory interstitial pulmonary macrophages.
Yuan H, He Y, Zhang Y, Min H, Chen J, Li C
The Science of the total environment 2024 Oct 10;946:174299
The Science of the total environment 2024 Oct 10;946:174299
Gastrodin Regulates PI3K/AKT-Sirt3 Signaling Pathway and Proinflammatory Mediators in Activated Microglia.
Zuo HJ, Wang PX, Ren XQ, Shi HL, Shi JS, Guo T, Wan C, Li JJ
Molecular neurobiology 2024 May;61(5):2728-2744
Molecular neurobiology 2024 May;61(5):2728-2744
Effect of CTLA-4 Inhibition on Inflammation and Apoptosis After Spinal Cord Injury.
Mao W, Jiang F, Zhu C, Liu J, Lu Z, Qian Y, Xiao J
Neurochemical research 2024 May;49(5):1359-1372
Neurochemical research 2024 May;49(5):1359-1372
Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction.
Takahashi K, Tsuji M, Nakagawasai O, Katsuyama S, Miyagawa K, Kurokawa K, Mochida-Saito A, Takeda H, Tadano T
Neurochemistry international 2024 May;175:105723
Neurochemistry international 2024 May;175:105723
Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.
Chen X, Wang B, Zhou Y, Wu X, Du A, Al Mamun A, Xu Y, Wang S, Jiang C, Xie L, Zhou K, Hu S, Xiao J
Advanced healthcare materials 2024 May;13(12):e2303462
Advanced healthcare materials 2024 May;13(12):e2303462
Photothermal and Photocatalytic Glycol Chitosan and Polydopamine-Grafted Oxygen Vacancy Bismuth Oxyiodide (BiO(1-x) I) Nanoparticles for the Diagnosis and Targeted Therapy of Diabetic Wounds.
Kong J, Ma S, Chu R, Liu J, Yu H, Mao M, Ge X, Sun Y, Wang Y
Advanced materials (Deerfield Beach, Fla.) 2024 Mar;36(11):e2307695
Advanced materials (Deerfield Beach, Fla.) 2024 Mar;36(11):e2307695
The Effect of Salvianolic Acid A on Tumor-Associated Macrophage Polarization and Its Mechanisms in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Tang C, Jiang ST, Li CX, Jia XF, Yang WL
Molecules (Basel, Switzerland) 2024 Mar 26;29(7)
Molecules (Basel, Switzerland) 2024 Mar 26;29(7)
Human amniotic MSCs-mediated anti-inflammation of CD206(hi)IL-10(hi) macrophages alleviates isoproterenol-induced ventricular remodeling in mice.
Huang QM, Long YL, Wang JN, Wu J, Tang WL, Wang XY, Zhang ZH, Zhuo YQ, Guan XH, Deng KY, Xin HB
International immunopharmacology 2024 Mar 10;129:111660
International immunopharmacology 2024 Mar 10;129:111660
Astragaloside IV alleviates macrophage senescence and d-galactose-induced bone loss in mice through STING/NF-κB pathway.
Li M, Niu Y, Tian L, Zhang T, Zhou S, Wang L, Sun J, Wumiti T, Chen Z, Zhou Q, Ma Y, Guo Y
International immunopharmacology 2024 Mar 10;129:111588
International immunopharmacology 2024 Mar 10;129:111588
Laminin-derived peptide, IKVAV, modulates macrophage phenotype through integrin mediation.
Jha A, Moore E
Matrix biology plus 2024 Jun;22:100143
Matrix biology plus 2024 Jun;22:100143
Multifunctional Biodegradable Conductive Hydrogel Regulating Microenvironment for Stem Cell Therapy Enhances the Nerve Tissue Repair.
Xu C, Wu P, Yang K, Mu C, Li B, Li X, Wang Z, Liu Z, Wang X, Luo Z
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(23):e2309793
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(23):e2309793
Prednisone combined with Dihydroartemisinin attenuates systemic lupus erythematosus by regulating M1/M2 balance through the MAPK signaling pathway.
Chen Y, Tao T, Liang Z, Chen X, Xu Y, Zhang T, Zhou D
Molecular immunology 2024 Jun;170:144-155
Molecular immunology 2024 Jun;170:144-155
Exosome/antimicrobial peptide laden hydrogel wound dressings promote scarless wound healing through miR-21-5p-mediated multiple functions.
Yang Y, Zhang J, Wu S, Deng Y, Wang S, Xie L, Li X, Yang L
Biomaterials 2024 Jul;308:122558
Biomaterials 2024 Jul;308:122558
Injectable, Electroconductive, Free Radical Scavenging Silk Fibroin/Black Phosphorus/Glycyrrhizic Acid Nanocomposite Hydrogel for Enhancing Spinal Cord Repair.
Zhang B, Wang W, Gao P, Li X, Chen L, Lin Z, Chen H, Liang W, Kong Z, Lin D, Wu X, Zhang T
Advanced healthcare materials 2024 Jul;13(18):e2304300
Advanced healthcare materials 2024 Jul;13(18):e2304300
Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1.
Wang R, Liang Z, Xue X, Mei H, Ji L, Wang B, Chen W, Gao C, Yuan S, Wu T, Qi H, Hu S, Yi L, Song Y, Liao R, Chen B
Journal of cellular and molecular medicine 2024 Jan;28(1):e18007
Journal of cellular and molecular medicine 2024 Jan;28(1):e18007
Extract of Astragali Radix and Solanum nigrum Linne regulates microglia and macrophage polarization and inhibits the growth and infiltration of C6 glioblastoma.
Shen M, Liu S, Wei Q, Zhang X, Wen S, Qiu R, Li Y, Fan H
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117067
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117067
Extracellular vesicles derived from monomeric α-synuclein-treated microglia ameliorate neuroinflammation by delivery of miRNAs targeting PRAK.
Li N, Huang Y, Wu Y, Wang Q, Ji P
Neuroscience letters 2024 Jan 1;818:137562
Neuroscience letters 2024 Jan 1;818:137562
Moluodan promotes DSS-induced intestinal inflammation involving the reprogram of macrophage function and polarization.
Zhao M, Qiao C, Cui Z, Zhang W, Yang S, Zhu C, Du F, Ning T, Xie S, Liu S, Li P, Xu J, Zhu S
Journal of ethnopharmacology 2024 Feb 10;320:117393
Journal of ethnopharmacology 2024 Feb 10;320:117393
S100A9 Induces Macrophage M2 Polarization and Immunomodulatory Role in the Lesion Site After Spinal Cord Injury in Rats.
Lv J, Wang Z, Wang B, Deng C, Wang W, Sun L
Molecular neurobiology 2024 Aug;61(8):5525-5540
Molecular neurobiology 2024 Aug;61(8):5525-5540
Azithromycin regulates Mettl3-mediated NF-κB pathway to enhance M2 polarization of RAW264.7 macrophages and attenuate LPS-triggered cytotoxicity of MLE-12 alveolar cells.
Xu S, Xing J, Zheng L, Su H, Zou Y, Niu Y, Di H
International immunopharmacology 2024 Aug 20;137:112426
International immunopharmacology 2024 Aug 20;137:112426
Combined untargeted metabolomics and network pharmacology approaches to reveal the therapeutic role of withanolide B in psoriasis.
Li T, Gao S, Wei Y, Wu G, Feng Y, Wang Y, Jiang X, Kuang H, Han W
Journal of pharmaceutical and biomedical analysis 2024 Aug 1;245:116163
Journal of pharmaceutical and biomedical analysis 2024 Aug 1;245:116163
Investigation of anti-depression effects and potential mechanisms of the ethyl acetate extract of Cynomorium songaricum Rupr. through the integration of in vivo experiments, LC-MS/MS chemical analysis, and a systems biology approach.
Zhang X, Li L, Chen J, Hu M, Zhang Y, Zhang X, Lu Y
Frontiers in pharmacology 2023;14:1239197
Frontiers in pharmacology 2023;14:1239197
BMP7 Attenuates Neuroinflammation after Spinal Cord Injury by Suppressing the Microglia Activation and Inducing Microglial Polarization Via the STAT3 Pathway.
Wei X, Huang C, Chen K, Liu S, Wang M, Yang L, Wang Y
Neurochemical research 2023 Sep;48(9):2687-2700
Neurochemical research 2023 Sep;48(9):2687-2700
Salidroside ameliorated the pulmonary inflammation induced by cigarette smoke via mitigating M1 macrophage polarization by JNK/c-Jun.
Feng H, Zhang D, Yin Y, Kang J, Zheng R
Phytotherapy research : PTR 2023 Sep;37(9):4251-4264
Phytotherapy research : PTR 2023 Sep;37(9):4251-4264
CD73 inhibits titanium particle-associated aseptic loosening by alternating activation of macrophages.
Sun Z, Kang J, Yang S, Zhang Y, Huang N, Zhang X, Du G, Jiang J, Ning B
International immunopharmacology 2023 Sep;122:110561
International immunopharmacology 2023 Sep;122:110561
A multifunctional polydopamine/genipin/alendronate nanoparticle licences fibrin hydrogels osteoinductive and immunomodulatory potencies for repairing bone defects.
Shi W, Gao Y, Wu Y, Sun J, Xu B, Lu X, Wang Q
International journal of biological macromolecules 2023 Sep 30;249:126072
International journal of biological macromolecules 2023 Sep 30;249:126072
Critical contributions of protein cargos to the functions of macrophage-derived extracellular vesicles.
Liu B, Nguyen PL, Yu H, Li X, Wang H, Price J, Niu M, Guda C, Cheng X, Sun X, Moreau R, Ramer-Tait A, Naldrett MJ, Alvarez S, Yu J
Journal of nanobiotechnology 2023 Sep 28;21(1):352
Journal of nanobiotechnology 2023 Sep 28;21(1):352
Gd-EOB MRI for HCC subtype differentiation in a western population according to the 5(th) edition of the World Health Organization classification.
Auer TA, Halskov S, Fehrenbach U, Nevermann NF, Pelzer U, Mohr R, Hamm B, Schöning W, Horst D, Ihlow J, Geisel D
European radiology 2023 Oct;33(10):6902-6915
European radiology 2023 Oct;33(10):6902-6915
Autophagy suppression facilitates macrophage M2 polarization via increased instability of NF-κB pathway in hepatocellular carcinoma.
Gao Z, Li XG, Feng SR, Chen JF, Song K, Shi YH, Tang Z, Liu WR, Zhang X, Huang A, Luo XM, Zeng HY, Gao Q, Shi GM, Ke AW, Zhou J, Fan J, Fu XT, Ding ZB
International immunopharmacology 2023 Oct;123:110685
International immunopharmacology 2023 Oct;123:110685
Low-dose adropin stimulates inflammasome activation of macrophage via mitochondrial ROS involved in colorectal cancer progression.
Jia L, Liao L, Jiang Y, Hu X, Lu G, Xiao W, Gong W, Jia X
BMC cancer 2023 Oct 30;23(1):1042
BMC cancer 2023 Oct 30;23(1):1042
Ultrasound-Induced Gold Nanoparticle United with Acoustic Reprogramming of Macrophages for Enhanced Cancer Therapy.
Tang Q, Zhang F, Luo L, Duan Y, Zhu T, Ni Y, Wang Y, Qi H, Jiang S, Zhou J, Ma X, Zhang Y
ACS applied materials & interfaces 2023 Oct 25;
ACS applied materials & interfaces 2023 Oct 25;
IGF2BP3 drives gallbladder cancer progression by m6A-modified CLDN4 and inducing macrophage immunosuppressive polarization.
Qin J, Cui Z, Zhou J, Zhang B, Lu R, Ding Y, Hu H, Cai J
Translational oncology 2023 Nov;37:101764
Translational oncology 2023 Nov;37:101764
Dauricine regulates prostate cancer progression by inhibiting PI3K/AKT-dependent M2 polarization of macrophages.
Li M, Che N, Liu X, Xuan Y, Jin Y
Biochemical pharmacology 2023 Nov;217:115838
Biochemical pharmacology 2023 Nov;217:115838
The metabolite butyrate produced by gut microbiota inhibits cachexia-associated skeletal muscle atrophy by regulating intestinal barrier function and macrophage polarization.
Liu H, Xi Q, Tan S, Qu Y, Meng Q, Zhang Y, Cheng Y, Wu G
International immunopharmacology 2023 Nov;124(Pt B):111001
International immunopharmacology 2023 Nov;124(Pt B):111001
Garlic-derived exosomes carrying miR-396e shapes macrophage metabolic reprograming to mitigate the inflammatory response in obese adipose tissue.
Bian Y, Li W, Jiang X, Yin F, Yin L, Zhang Y, Guo H, Liu J
The Journal of nutritional biochemistry 2023 Mar;113:109249
The Journal of nutritional biochemistry 2023 Mar;113:109249
Tongxinluo promotes endothelium-dependent arteriogenesis to attenuate diabetic peripheral arterial disease.
Gu JJ, Hou YL, Yan YH, Li J, Wei YR, Ma K, Wang XQ, Zhang JH, Wang DD, Li CR, Li DQ, Sun LL, Gao HL
World journal of diabetes 2023 Mar 15;14(3):234-254
World journal of diabetes 2023 Mar 15;14(3):234-254
Lacticaseibacillus casei CNRZ1874 supplementation promotes M1 alveolar macrophage activation and attenuates Mycoplasma pneumoniae pneumonia.
Zhang N, Zeng W, Du T, Wei H, Tian W, Meng Y, He G, Lei A, Zhu C
Journal of applied microbiology 2023 Mar 1;134(3)
Journal of applied microbiology 2023 Mar 1;134(3)
Targeting of Annexin A1 in Tumor-associated Macrophages as a therapeutic strategy for hepatocellular carcinoma.
Song Z, Wang X, Liu X, Luo Y, Qiu J, Yin A, Liu Y, Yi H, Xiao Z, Li A
Biochemical pharmacology 2023 Jul;213:115612
Biochemical pharmacology 2023 Jul;213:115612
Selenium-Doped Mesoporous Bioactive Glass Regulates Macrophage Metabolism and Polarization by Scavenging ROS and Promotes Bone Regeneration In Vivo.
Chen D, Liang Z, Su Z, Huang J, Pi Y, Ouyang Y, Luo T, Guo L
ACS applied materials & interfaces 2023 Jul 26;15(29):34378-34396
ACS applied materials & interfaces 2023 Jul 26;15(29):34378-34396
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.
Southwell N, Primiano G, Nadkarni V, Attarwala N, Beattie E, Miller D, Alam S, Liparulo I, Shurubor YI, Valentino ML, Carelli V, Servidei S, Gross SS, Manfredi G, Chen Q, D'Aurelio M
EMBO molecular medicine 2023 Jul 10;15(7):e16951
EMBO molecular medicine 2023 Jul 10;15(7):e16951
Arthritic Microenvironment Actuated Nanomotors for Active Rheumatoid Arthritis Therapy.
Xu C, Jiang Y, Wang H, Zhang Y, Ye Y, Qin H, Gao J, Dan Q, Du L, Liu L, Peng F, Li Y, Tu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(4):e2204881
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(4):e2204881
FNDC5/Irisin Inhibits the Inflammatory Response and Mediates the Aerobic Exercise-Induced Improvement of Liver Injury after Myocardial Infarction.
Wang T, Yu M, Li H, Qin S, Ren W, Ma Y, Bo W, Xi Y, Cai M, Tian Z
International journal of molecular sciences 2023 Feb 19;24(4)
International journal of molecular sciences 2023 Feb 19;24(4)
Deferoxamine prevents poststroke memory impairment in female diabetic rats: potential links to hemorrhagic transformation and ferroptosis.
Li W, Abdul Y, Chandran R, Jamil S, Ward RA, Abdelsaid M, Dong G, Fagan SC, Ergul A
American journal of physiology. Heart and circulatory physiology 2023 Feb 1;324(2):H212-H225
American journal of physiology. Heart and circulatory physiology 2023 Feb 1;324(2):H212-H225
CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-κB pathway.
Liu C, Yao K, Tian Q, Guo Y, Wang G, He P, Wang J, Wang J, Zhang Z, Li M
Redox biology 2023 Dec;68:102960
Redox biology 2023 Dec;68:102960
Neurovascular dysfunction associated with erectile dysfunction persists after long-term recovery from simulations of weightlessness and deep space irradiation.
Andrade MR, Azeez TA, Montgomery MM, Caldwell JT, Park H, Kwok AT, Borg AM, Narayanan SA, Willey JS, Delp MD, La Favor JD
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23246
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23246
The effects of astragaloside IV on gut microbiota and serum metabolism in a mice model of intracerebral hemorrhage.
Li Z, Hu E, Zheng F, Wang S, Zhang W, Luo J, Tang T, Huang Q, Wang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155086
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155086
Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization.
Shen T, Lin R, Hu C, Yu D, Ren C, Li T, Zhu M, Wan Z, Su T, Wu Y, Cai W, Yu J
Journal of neuroinflammation 2023 Dec 21;20(1):308
Journal of neuroinflammation 2023 Dec 21;20(1):308
TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation.
Wu Y, Zhan S, Chen L, Sun M, Li M, Mou X, Zhang Z, Xu L, Xu Y
Journal of translational medicine 2023 Aug 14;21(1):544
Journal of translational medicine 2023 Aug 14;21(1):544
CCL6 promotes M2 polarization and inhibits macrophage autophagy by activating PI3-kinase/Akt signalling pathway during skin wound healing.
Feng X, Ji Y, Zhang C, Jin T, Li J, Guo J
Experimental dermatology 2023 Apr;32(4):403-412
Experimental dermatology 2023 Apr;32(4):403-412
Menstrual blood-derived endometrial stem cells alleviate neuroinflammation by modulating M1/M2 polarization in cell and rat Parkinson's disease models.
Li H, Wei J, Zhang Z, Li J, Ma Y, Zhang P, Lin J
Stem cell research & therapy 2023 Apr 13;14(1):85
Stem cell research & therapy 2023 Apr 13;14(1):85
Exosomes Derived From M2 Microglia Cells Attenuates Neuronal Impairment and Mitochondrial Dysfunction in Alzheimer's Disease Through the PINK1/Parkin Pathway.
Li N, Shu J, Yang X, Wei W, Yan A
Frontiers in cellular neuroscience 2022;16:874102
Frontiers in cellular neuroscience 2022;16:874102
Exploration of the potential mechanism of Pushen capsule in the treatment of vascular dementia based on network pharmacology and experimental verification.
Liu Y, Li S, Liu D, Wei H, Wang X, Yan F
Journal of ethnopharmacology 2022 Nov 15;298:115632
Journal of ethnopharmacology 2022 Nov 15;298:115632
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Kou L, Chi X, Sun Y, Han C, Wan F, Hu J, Yin S, Wu J, Li Y, Zhou Q, Zou W, Xiong N, Huang J, Xia Y, Wang T
Journal of neuroinflammation 2022 Jun 6;19(1):133
Journal of neuroinflammation 2022 Jun 6;19(1):133
Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats.
Liu Q, Zhou S, Wang X, Gu C, Guo Q, Li X, Zhang C, Zhang N, Zhang L, Huang F
Journal of neuroinflammation 2022 Jun 20;19(1):160
Journal of neuroinflammation 2022 Jun 20;19(1):160
Neuroglobin alleviates the neurotoxicity of sevoflurane to fetal rats by inhibiting neuroinflammation and affecting microglial polarization.
Zhang Y, Gao Y, Yang F, Wu X, Tang Z, Liu H
Brain research bulletin 2022 Jun 1;183:142-152
Brain research bulletin 2022 Jun 1;183:142-152
Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway.
Li J, Liu H, Wang X, Xia Y, Huang J, Wang T, Lin Z, Xiong N
NPJ Parkinson's disease 2022 Jul 8;8(1):90
NPJ Parkinson's disease 2022 Jul 8;8(1):90
microRNA-155-3p delivered by M2 macrophages-derived exosomes enhances the progression of medulloblastoma through regulation of WDR82.
Song L, Luan B, Xu Q, Shi R, Wang X
Journal of translational medicine 2022 Jan 4;20(1):13
Journal of translational medicine 2022 Jan 4;20(1):13
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
Ni L, Xiao J, Zhang D, Shao Z, Huang C, Wang S, Wu Y, Tian N, Sun L, Wu A, Zhou Y, Wang X, Zhang X
Cell death & disease 2022 Feb 10;13(2):140
Cell death & disease 2022 Feb 10;13(2):140
ALA-PDT regulates macrophage M1 polarization via ERK/MAPK-NLRP3 pathway to promote the early inflammatory response.
Wang L, Zhang W, Cen R, Yue C, Xiao T, Deng Y, Li L, Sun K, Lei X
Lasers in surgery and medicine 2022 Dec;54(10):1309-1320
Lasers in surgery and medicine 2022 Dec;54(10):1309-1320
Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism.
Li L, Xu W, Luo Y, Lao C, Tong X, Du J, Huang B, Li D, Chen J, Ye H, Cong F, Guo X, Li J
Carbohydrate polymers 2022 Dec 1;297:120032
Carbohydrate polymers 2022 Dec 1;297:120032
Macrophage depletion blocks congenital SARM1-dependent neuropathy.
Dingwall CB, Strickland A, Yum SW, Yim AK, Zhu J, Wang PL, Yamada Y, Schmidt RE, Sasaki Y, Bloom AJ, DiAntonio A, Milbrandt J
The Journal of clinical investigation 2022 Dec 1;132(23)
The Journal of clinical investigation 2022 Dec 1;132(23)
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Ni L, Lin Z, Hu S, Shi Y, Jiang Z, Zhao J, Zhou Y, Wu Y, Tian N, Sun L, Wu A, Pan Z, Zhang X, Wang X
Biochemical pharmacology 2022 Apr;198:114935
Biochemical pharmacology 2022 Apr;198:114935
Rosuvastatin Nanomicelles Target Neuroinflammation and Improve Neurological Deficit in a Mouse Model of Intracerebral Hemorrhage.
Zi L, Zhou W, Xu J, Li J, Li N, Xu J, You C, Wang C, Tian M
International journal of nanomedicine 2021;16:2933-2947
International journal of nanomedicine 2021;16:2933-2947
Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization.
Yang R, Xie Y, Li Q, Ye Y, Shi Y, Zhao X, Wu C, Xu Y, Wang R, Zhang Y, Yang X, Han X, Liu S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Sep;141:111883
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Sep;141:111883
The Cholinergic Anti-Inflammatory Pathway Attenuates the Development of Atherosclerosis in Apoe(-/-) Mice through Modulating Macrophage Functions.
Qian Z, Yang H, Li H, Liu C, Yang L, Qu Z, Li X
Biomedicines 2021 Sep 3;9(9)
Biomedicines 2021 Sep 3;9(9)
Reactive astrocytes induced by 2-chloroethanol modulate microglia polarization through IL-1β, TNF-α, and iNOS upregulation.
Wang T, Sun Q, Yang J, Wang G, Zhao F, Chen Y, Jin Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112550
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112550
The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization.
Li W, Wang Y, Zhu L, Du S, Mao J, Wang Y, Wang S, Bo Q, Tu Y, Yi Q
Journal of cellular and molecular medicine 2021 Jul;25(14):6709-6720
Journal of cellular and molecular medicine 2021 Jul;25(14):6709-6720
Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis.
Abdul Y, Li W, Ward R, Abdelsaid M, Hafez S, Dong G, Jamil S, Wolf V, Johnson MH, Fagan SC, Ergul A
Translational stroke research 2021 Aug;12(4):615-630
Translational stroke research 2021 Aug;12(4):615-630
Injectable Gelatin Hydrogel Suppresses Inflammation and Enhances Functional Recovery in a Mouse Model of Intracerebral Hemorrhage.
Xu J, Duan Z, Qi X, Ou Y, Guo X, Zi L, Wei Y, Liu H, Ma L, Li H, You C, Tian M
Frontiers in bioengineering and biotechnology 2020;8:785
Frontiers in bioengineering and biotechnology 2020;8:785
Neuroprotective Effect of Ketone Metabolism on Inhibiting Inflammatory Response by Regulating Macrophage Polarization After Acute Cervical Spinal Cord Injury in Rats.
Lin J, Huang Z, Liu J, Huang Z, Liu Y, Liu Q, Yang Z, Li R, Wu X, Shi Z, Zhu Q, Wu X
Frontiers in neuroscience 2020;14:583611
Frontiers in neuroscience 2020;14:583611
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Lou F, Sun Y, Xu Z, Niu L, Wang Z, Deng S, Liu Z, Zhou H, Bai J, Yin Q, Cai X, Sun L, Wang H, Li Q, Wu Z, Chen X, Gu J, Shi YL, Tao W, Ginhoux F, Wang H
Immunity 2020 Jul 14;53(1):204-216.e10
Immunity 2020 Jul 14;53(1):204-216.e10
Intravenously Infusing the Secretome of Adipose-Derived Mesenchymal Stem Cells Ameliorates Neuroinflammation and Neurological Functioning After Traumatic Brain Injury.
Xu C, Diao YF, Wang J, Liang J, Xu HH, Zhao ML, Zheng B, Luan Z, Wang JJ, Yang XP, Wei MG, Duan JH, Wang KQ, Chen C, Chen F, Ming D, Zhang S, Sun HT, Li XH
Stem cells and development 2020 Feb 15;29(4):222-234
Stem cells and development 2020 Feb 15;29(4):222-234
Lipoxin A4 Regulates Lipopolysaccharide-Induced BV2 Microglial Activation and Differentiation via the Notch Signaling Pathway.
Wu J, Ding DH, Li QQ, Wang XY, Sun YY, Li LJ
Frontiers in cellular neuroscience 2019;13:19
Frontiers in cellular neuroscience 2019;13:19
Effects of exposure of adult mice to multi-walled carbon nanotubes on the liver lipid metabolism of their offspring.
Zhang HY, Chen RL, Shao Y, Wang HL, Liu ZG
Toxicology research 2018 Sep 1;7(5):809-816
Toxicology research 2018 Sep 1;7(5):809-816
Involvement of JNK signaling in IL4-induced M2 macrophage polarization.
Hao J, Hu Y, Li Y, Zhou Q, Lv X
Experimental cell research 2017 Aug 15;357(2):155-162
Experimental cell research 2017 Aug 15;357(2):155-162
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 66129-1-Ig(ARG1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The liver Arginase antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human liver Arginase. This antibody recognizes human antigen. The liver Arginase antibody has been validated for the following applications: ELISA, WB, IHC analysis.