Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [180]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 66129-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- Arginase-1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated Arginase-1 antibody (Cat. #66129-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, pig, rat, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 5D6D12
- Vial size
- 20ul, 150ul
Submitted references Lnc-CHRM4-2:1 Inhibits M2 Polarization and Efferocytosis of Macrophages by Downregulating MerTK and SLC2A1 in Rheumatoid Arthritis.
Gomphus floccosus (Schw.) Sing. extract attenuates alcoholic liver disease by suppressing macrophage glycolysis and M1 polarization.
A pH/ROS dual-responsive metal-polyphenol-antibiotic nano-assembly for combating persistent infection by overcoming biofilm and cell membrane barriers.
Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell-Mediated Repair Traumatic Brain Injury.
Dihydroartemisinin-Loaded ZIF-8 Nanoparticles Elicit Chemo-Immunotherapy against Malignant Pleural Effusion via Inhibition of OCT4/M-CSF Signaling Pathway.
Ion interference induced by Ca-Mn nanoplatform enhances ferroptosis and promotes immune response for osteosarcoma treatment.
Vaccination of mice with Trichinella spiralis serine proteinase enhanced gut epithelial barrier and elicited a high protective immunity.
Mesenchymal Stem Cell-Derived Apoptotic Micro-Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis.
Mechanically Preconditioned Biomimetic Gradient Scaffold for Tendon-to-Bone Regeneration in a Rabbit Rotator Cuff Tear Model.
ZG16 represses tumor progression and M2 polarization of tumor-associated macrophages in hepatocellular carcinoma by promoting ubiquitination and degradation of SNX9 via binding to ITCH.
Repurposing dronedarone induces ferroptosis through GPX4 inactivation and degradation in pancreatic cancer.
Integrative network toxicology and single-cell transcriptomics reveal TP53 as a key mediator of PCBs-induced microglial dysfunction in diabetic retinopathy.
AICAR improves depression-like behaviors and is associated with hippocampal AMPK activation and modulation of neurogenesis and neuroinflammation in a microbiota disruption model.
The PTBP1-EZH2-DOCK2 axis promotes M1 microglial polarization and exacerbates neuronal apoptosis following spinal cord injury.
Immunomodulatory mesoporous bioactive glass/interleukin-4 nanocomplex promotes bone regeneration.
Daucosterol ameliorates acute inflammation and fibrosis following myocardial infarction via regulation of the ZBTB16 protein.
Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug-Releasing Capability for the Programmable Repair of Spinal Cord Injury.
Study on the role and mechanism of the IL-10-IRF-8 signaling pathway in bone marrow mesenchymal stem cell therapy for pain in CCD rats.
Taurine-loaded covalent organic frameworks for alleviating post-radiation bone regeneration disorder.
TWEAK exacerbates allergic conjunctivitis via PKM2-dependent NF-κB activation and macrophage M1 polarization.
DCC-2036 induces repolarization of TAMs to M1 type and enhances CD8(+) T cell immunity in TNBC.
Framework nucleic acid-based hydrogel for sequential immune regulation and endogenous TGF-β1 capture in wound healing.
Kakkalide promotes spinal cord injury repair by regulating microglial M2 polarization via mitophagy.
Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds.
CAR-M2 immunotherapy resolves renal fibrosis via revascularization and apoptosis of profibrotic Cxcr2(+) endothelial cells.
eNAMPT/Ac-STAT3/DIRAS2 Axis Promotes Development and Cancer Stemness in Triple-Negative Breast Cancer by Enhancing Cytokine Crosstalk Between Tumor-Associated Macrophages and Cancer Cells.
Tumor-associated macrophages drive heterogenetic CD10(High) cancer stem cells to implement tumor-associated neutrophils reprogramming in oral squamous cell carcinoma.
Single-cell transcriptomic analysis reveals the association of Ccl6+Ccr2+Arg1+ macrophages with renal interstitial fibrosis in AKI.
TGF-β-Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization.
Modified Sijunzi Decoction Inhibits Pancreatic Cancer Progression and Improves Immune Suppression: Network Pharmacology and Experimental Validation.
ZnO NPs Attenuate LPS-Induced Inflammation in RAW264.7 Macrophages by Inhibiting NF-κB and JAK1-STAT1/STAT3 Pathways and Reducing ROS.
Anti atherosclerosis effect and mechanism of a novel curcumin analogue CACN136: regulating macrophage M1/M2 polarization and lipid metabolism.
GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.
Extracellular vesicles derived from irradiated oral squamous cell carcinoma cells inhibits M2 macrophage polarization by the miR-198-5p/MYD88 axis.
Exogenous M2 Macrophage-Loaded Scaffolds Promote Early Periodontal Regeneration by Improving Osteogenic Differentiation, Cell Homing, and Angiogenesis.
Phlorizin Alleviates Depression-like Behaviors via Gut Microbiota Reprogramming-Induced Methionine to Inhibit Neuroinflammation in Mice Hippocampus.
FPR2 Agonism Attenuates Restenosis by Mitigating Neointimal Hyperplasia via ELOVL6.
Co-assembled polypeptides-adsorbing bridge molecules to enhance macrophage efferocytosis for the resolution of periodontitis inflammation.
INHBA, transcriptionally activated by SPI1, facilitates gastric cancer progression by inducing macrophage recruitment and M2 polarization via activating the TGF-β signaling to increase CCL2.
Orally Deliverable Iron-Ceria Nanotablets for Treatment of Inflammatory Bowel Disease.
Excessive MYC Orchestrates Macrophages induced Chromatin Remodeling to Sustain Micropapillary-Patterned Malignancy in Lung Adenocarcinoma.
Genetically Programmed Single-Component Protein Hydrogel for Spinal Cord Injury Repair.
Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model.
P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin-Dependent Mitophagy After Spinal Cord Injury.
Activation of GPER1 alleviates white matter injury by promoting microglia M2 polarization through EGFR/Stat3 pathway in intracerebral hemorrhage mice.
Enhanced inhibition of neuronal ferroptosis and regulation of microglial polarization with multifunctional traditional Chinese medicine active ingredients-based selenium nanoparticles for treating spinal cord injury.
K(+)-H(+) coupling strategy for immune regulation and bone defect repair.
Myeloid-specific deficiency of group VIA calcium-independent phospholipase A2 preconditions myeloid cells for injury resolution after acetaminophen exposure.
Exploring the Unique Extracellular Matrix Composition of Acomys as a Potential Key to Resisting Fibrosis.
Construction of cartilaginous organoids based on cartilage extracellular matrix microcarriers to promote articular cartilage regeneration through immune regulation.
Immune-modulated adhesive hydrogel for enhancing osteochondral graft adhesion and cartilage repair.
Activation of Hippocampal ACE2 Prevents the Dysbiosis-induced Depression-like Behavior in Mice by Enhanced Neurogenesis and Neuroprotection via Mas Receptor.
Exogenous arginine differentially regulates inflammatory cytokine and inducible nitric oxide synthase expression in macrophages.
Ultrasound-Triggered Nanogel Boosts Chemotherapy and Immunomodulation in Colorectal Cancer.
Danhong injection modulates microglial polarization and neuroinflammation via the JUNB/NF-κB pathway in ischemic stroke.
Gut commensal bacteria Parabacteroides goldsteinii-derived outer membrane vesicles suppress skin inflammation in psoriasis.
KAT3B-mediated succinylation of DERL3 suppresses osteogenic differentiation by promoting M1/M2 macrophage polarization.
Electroacupuncture normalized tumor vasculature by downregulating glyoxalase-1 to polarize tumor-associated macrophage to M1 phenotype in triple-negative breast cancer.
Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury.
ITIH5-mediated fibroblast/macrophage crosstalk exacerbates cardiac remodelling after myocardial infarction.
Anti-Neuroinflammatory Eremophilane Sesquiterpenoids from Marine-Derived Fungus Phoma sp. DXH009.
Inflammatory memory-activated biomimetic nanovesicles regulate neutrophil plasticity and metabolic reprogramming for rapid diabetic wound healing via targeting miR-193a-5p/TLR4/JNK/P38 MAPK pathways.
Inhibition of Macrophage Activation by Minocycline Attenuates CCI-Induced Neuropathic Pain.
Farrerol confers neuroprotection in spinal cord injury by regulating macrophages/microglia polarization through the JAK2/STAT3 pathway.
4'-hydroxychalcone nanofiber hydrogel dressing promotes diabetic chronic wound healing by regulating macrophage polarization via the TLR/IL-17/TNF signaling pathway.
ASFV activates STAT3 to induce proviral M2 macrophage polarization.
Transglutaminase-2 Promotes Microglial Synaptic Phagocytosis and Ameliorates Epileptic Seizures by Inhibiting ABCA1 Ubiquitination.
A Novel TLR4 Inhibitor DB03476 Rescued Renal Inflammation in Acute Kidney Injury Model.
Sirtuin 3 promotes osteogenic differentiation of bone marrow mesenchymal stem cells by regulating macrophage polarization under high glucose.
tsRNA-10105-enriched migrasomes mediate hepatocellular carcinoma immunosuppressive microenvironment by inducing M2 Macrophage polarization.
Baicalein attenuates metabolic dysfunction-associated steatohepatitis by regulating macrophage ferroptosis through nuclear factor (erythroid-derived 2)-like 2 pathway.
Black phosphorus nanosheets promote neuronal differentiation of neural stem cells through adhesion and pinocytosis for spinal cord injury repair.
Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3-Regulated HIF1A/HMOX1 Signaling Pathway.
Astrocytic ET-1 System Determines Microglia Phenotype Following Spinal Cord Injury.
Mechanistic Study of Jaceosidin in Regulating Secondary Inflammation After Spinal Cord Injury in Mouse by Inhibiting PKM2 Activity.
Piezo1 promotes colitis progression by modulating the Nrf2/NF-κB/NLRP3 signaling pathway.
Multiomics integration analysis identifies tumor cell-derived MIF as a therapeutic target and potentiates anti-PD-1 therapy in osteosarcoma.
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Inhibition of glutaminase 1 reduces M1 macrophage polarization to protect against monocrotaline-induced pulmonary arterial hypertension.
A Smart MMP-9-responsive Hydrogel Releasing M2 Macrophage-derived Exosomes for Diabetic Wound Healing.
Mannose-Glycated Metal-Phenolic Microcapsules Orchestrate Phenotype Switch of Macrophages for Boosting Tumor Immunotherapy.
Fermented Cordyceps Powder alleviates silica-induced inflammation and fibrosis by inhibiting M1 macrophage polarization via the HMGB1-TLR4-NF-κB pathway.
Genetically Modified Hepatocytes Targeting Bilirubin and Ammonia Metabolism for the Construction of Bioartificial Liver System.
Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.
FoxO1-Overexpressed Small Extracellular Vesicles Derived from hPDLSCs Promote Periodontal Tissue Regeneration by Reducing Mitochondrial Dysfunction to Regulate Osteogenesis and Inflammation.
Myeloid Deletion of Cdc42 Protects Liver From Hepatic Ischemia-Reperfusion Injury via Inhibiting Macrophage-Mediated Inflammation in Mice.
Protective effects of berbamine against arginase-1 deficiency-induced injury in human brain microvascular endothelial cells.
Inhibition of PTEN promotes osteointegration of titanium implants in type 2 diabetes by enhancing anti-inflammation and osteogenic capacity of adipose-derived stem cells.
Propionate-producing engineered probiotics ameliorated murine ulcerative colitis by restoring anti-inflammatory macrophage via the GPR43/HDAC1/IL-10 axis.
3D printing of interferon γ-preconditioned NSC-derived exosomes/collagen/chitosan biological scaffolds for neurological recovery after TBI.
Ocotillol-Type Pseudoginsenoside-F11 Alleviates Lipopolysaccharide-Induced Acute Kidney Injury through Regulation of Macrophage Function by Suppressing the NF-κB/NLRP3/IL-1β Signaling Pathway.
A Hirsutella sinensis Alcohol Extract Exerts Bidirectional Immunoregulatory Effects by Regulating Macrophage Polarization.
YIGSR, A Laminin-Derived Peptide, Dictates a Concentration-Dependent Impact on Macrophage Phenotype Response.
Leukocyte infiltration and cross-talk with cardiomyocytes exploit intracellular stress pathways in dilated cardiomyopathy of idiopathic origin.
Crystalline silica-induced endoplasmic reticulum stress promotes the pathogenesis of silicosis by augmenting proinflammatory interstitial pulmonary macrophages.
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
TREM1 promotes neuroinflammation after traumatic brain injury in rats: Possible involvement of ERK/cPLA2 signalling pathway.
Gastrodin Regulates PI3K/AKT-Sirt3 Signaling Pathway and Proinflammatory Mediators in Activated Microglia.
Effect of CTLA-4 Inhibition on Inflammation and Apoptosis After Spinal Cord Injury.
Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction.
Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.
Photothermal and Photocatalytic Glycol Chitosan and Polydopamine-Grafted Oxygen Vacancy Bismuth Oxyiodide (BiO(1-x) I) Nanoparticles for the Diagnosis and Targeted Therapy of Diabetic Wounds.
The Effect of Salvianolic Acid A on Tumor-Associated Macrophage Polarization and Its Mechanisms in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Human amniotic MSCs-mediated anti-inflammation of CD206(hi)IL-10(hi) macrophages alleviates isoproterenol-induced ventricular remodeling in mice.
Astragaloside IV alleviates macrophage senescence and d-galactose-induced bone loss in mice through STING/NF-κB pathway.
Laminin-derived peptide, IKVAV, modulates macrophage phenotype through integrin mediation.
Multifunctional Biodegradable Conductive Hydrogel Regulating Microenvironment for Stem Cell Therapy Enhances the Nerve Tissue Repair.
Prednisone combined with Dihydroartemisinin attenuates systemic lupus erythematosus by regulating M1/M2 balance through the MAPK signaling pathway.
Increase in GPIHBP1 expression in advanced stage colorectal cancer indicates poor immune surveillance.
Exosome/antimicrobial peptide laden hydrogel wound dressings promote scarless wound healing through miR-21-5p-mediated multiple functions.
Injectable, Electroconductive, Free Radical Scavenging Silk Fibroin/Black Phosphorus/Glycyrrhizic Acid Nanocomposite Hydrogel for Enhancing Spinal Cord Repair.
Silencing SPP1 in M2 macrophages inhibits the progression of castration-resistant prostate cancer via the MMP9/TGFβ1 axis.
miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1.
Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1.
Extract of Astragali Radix and Solanum nigrum Linne regulates microglia and macrophage polarization and inhibits the growth and infiltration of C6 glioblastoma.
Extracellular vesicles derived from monomeric α-synuclein-treated microglia ameliorate neuroinflammation by delivery of miRNAs targeting PRAK.
Moluodan promotes DSS-induced intestinal inflammation involving the reprogram of macrophage function and polarization.
Bromodomain containing 4 inhibition combats gastric precancerous lesions via modulating macrophage polarization.
Sirt3-Mediated Opa1 Deacetylation Protects Against Sepsis-Induced Acute Lung Injury by Inhibiting Alveolar Macrophage Pro-Inflammatory Polarization.
S100A9 Induces Macrophage M2 Polarization and Immunomodulatory Role in the Lesion Site After Spinal Cord Injury in Rats.
Apilarnil exerts neuroprotective effects and alleviates motor dysfunction by rebalancing M1/M2 microglia polarization, regulating miR-155 and miR-124 expression in a rotenone-induced Parkinson's disease rat model.
Azithromycin regulates Mettl3-mediated NF-κB pathway to enhance M2 polarization of RAW264.7 macrophages and attenuate LPS-triggered cytotoxicity of MLE-12 alveolar cells.
Combined untargeted metabolomics and network pharmacology approaches to reveal the therapeutic role of withanolide B in psoriasis.
Renalase mediates macrophage-to-fibroblast crosstalk to attenuate pressure overload-induced pathological myocardial fibrosis.
Investigation of anti-depression effects and potential mechanisms of the ethyl acetate extract of Cynomorium songaricum Rupr. through the integration of in vivo experiments, LC-MS/MS chemical analysis, and a systems biology approach.
BMP7 Attenuates Neuroinflammation after Spinal Cord Injury by Suppressing the Microglia Activation and Inducing Microglial Polarization Via the STAT3 Pathway.
Salidroside ameliorated the pulmonary inflammation induced by cigarette smoke via mitigating M1 macrophage polarization by JNK/c-Jun.
CD73 inhibits titanium particle-associated aseptic loosening by alternating activation of macrophages.
A multifunctional polydopamine/genipin/alendronate nanoparticle licences fibrin hydrogels osteoinductive and immunomodulatory potencies for repairing bone defects.
Critical contributions of protein cargos to the functions of macrophage-derived extracellular vesicles.
Gd-EOB MRI for HCC subtype differentiation in a western population according to the 5(th) edition of the World Health Organization classification.
Autophagy suppression facilitates macrophage M2 polarization via increased instability of NF-κB pathway in hepatocellular carcinoma.
Low-dose adropin stimulates inflammasome activation of macrophage via mitochondrial ROS involved in colorectal cancer progression.
PROMOTING MITOCHONDRIAL DYNAMIC EQUILIBRIUM ATTENUATES SEPSIS-INDUCED ACUTE LUNG INJURY BY INHIBITING PROINFLAMMATORY POLARIZATION OF ALVEOLAR MACROPHAGES.
IGF2BP3 drives gallbladder cancer progression by m6A-modified CLDN4 and inducing macrophage immunosuppressive polarization.
Dauricine regulates prostate cancer progression by inhibiting PI3K/AKT-dependent M2 polarization of macrophages.
The metabolite butyrate produced by gut microbiota inhibits cachexia-associated skeletal muscle atrophy by regulating intestinal barrier function and macrophage polarization.
Ultrasound-Induced Gold Nanoparticle United with Acoustic Reprogramming of Macrophages for Enhanced Cancer Therapy.
TMEM16F may be a new therapeutic target for Alzheimer's disease.
Garlic-derived exosomes carrying miR-396e shapes macrophage metabolic reprograming to mitigate the inflammatory response in obese adipose tissue.
Tongxinluo promotes endothelium-dependent arteriogenesis to attenuate diabetic peripheral arterial disease.
Lacticaseibacillus casei CNRZ1874 supplementation promotes M1 alveolar macrophage activation and attenuates Mycoplasma pneumoniae pneumonia.
Targeting of Annexin A1 in Tumor-associated Macrophages as a therapeutic strategy for hepatocellular carcinoma.
Selenium-Doped Mesoporous Bioactive Glass Regulates Macrophage Metabolism and Polarization by Scavenging ROS and Promotes Bone Regeneration In Vivo.
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.
Arthritic Microenvironment Actuated Nanomotors for Active Rheumatoid Arthritis Therapy.
FNDC5/Irisin Inhibits the Inflammatory Response and Mediates the Aerobic Exercise-Induced Improvement of Liver Injury after Myocardial Infarction.
Deferoxamine prevents poststroke memory impairment in female diabetic rats: potential links to hemorrhagic transformation and ferroptosis.
CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-κB pathway.
Neurovascular dysfunction associated with erectile dysfunction persists after long-term recovery from simulations of weightlessness and deep space irradiation.
The effects of astragaloside IV on gut microbiota and serum metabolism in a mice model of intracerebral hemorrhage.
Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization.
TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation.
CCL6 promotes M2 polarization and inhibits macrophage autophagy by activating PI3-kinase/Akt signalling pathway during skin wound healing.
Menstrual blood-derived endometrial stem cells alleviate neuroinflammation by modulating M1/M2 polarization in cell and rat Parkinson's disease models.
Exosomes Derived From M2 Microglia Cells Attenuates Neuronal Impairment and Mitochondrial Dysfunction in Alzheimer's Disease Through the PINK1/Parkin Pathway.
Exploration of the potential mechanism of Pushen capsule in the treatment of vascular dementia based on network pharmacology and experimental verification.
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats.
Neuroglobin alleviates the neurotoxicity of sevoflurane to fetal rats by inhibiting neuroinflammation and affecting microglial polarization.
Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway.
microRNA-155-3p delivered by M2 macrophages-derived exosomes enhances the progression of medulloblastoma through regulation of WDR82.
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
ALA-PDT regulates macrophage M1 polarization via ERK/MAPK-NLRP3 pathway to promote the early inflammatory response.
Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism.
Macrophage depletion blocks congenital SARM1-dependent neuropathy.
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Rosuvastatin Nanomicelles Target Neuroinflammation and Improve Neurological Deficit in a Mouse Model of Intracerebral Hemorrhage.
Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization.
The Cholinergic Anti-Inflammatory Pathway Attenuates the Development of Atherosclerosis in Apoe(-/-) Mice through Modulating Macrophage Functions.
Reactive astrocytes induced by 2-chloroethanol modulate microglia polarization through IL-1β, TNF-α, and iNOS upregulation.
The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization.
Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis.
Injectable Gelatin Hydrogel Suppresses Inflammation and Enhances Functional Recovery in a Mouse Model of Intracerebral Hemorrhage.
Neuroprotective Effect of Ketone Metabolism on Inhibiting Inflammatory Response by Regulating Macrophage Polarization After Acute Cervical Spinal Cord Injury in Rats.
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Intravenously Infusing the Secretome of Adipose-Derived Mesenchymal Stem Cells Ameliorates Neuroinflammation and Neurological Functioning After Traumatic Brain Injury.
Lipoxin A4 Regulates Lipopolysaccharide-Induced BV2 Microglial Activation and Differentiation via the Notch Signaling Pathway.
Effects of exposure of adult mice to multi-walled carbon nanotubes on the liver lipid metabolism of their offspring.
Involvement of JNK signaling in IL4-induced M2 macrophage polarization.
Chu J, Zang J, Zhang L, Qu Z, Li H, Yang C, Sun J, Gai L, Sun X, Xu D
Journal of immunology research 2026;2026(1):e1718207
Journal of immunology research 2026;2026(1):e1718207
Gomphus floccosus (Schw.) Sing. extract attenuates alcoholic liver disease by suppressing macrophage glycolysis and M1 polarization.
Ruan T, Li X, Li M, Wang S, Shen L, Liu C, Peng Y, Tao Y
Frontiers in immunology 2026;17:1772592
Frontiers in immunology 2026;17:1772592
A pH/ROS dual-responsive metal-polyphenol-antibiotic nano-assembly for combating persistent infection by overcoming biofilm and cell membrane barriers.
Du J, Zhang Q, Wang Z, Jin Y, Gao F, Kong Y, Bianco A, Ge S, Ma B
Biomaterials 2026 Oct;333:124168
Biomaterials 2026 Oct;333:124168
Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell-Mediated Repair Traumatic Brain Injury.
Zhou P, Wu Q, Wu Y, Huang R, Li W, Niu H, Sun H, Liu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(27):e24326
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(27):e24326
Dihydroartemisinin-Loaded ZIF-8 Nanoparticles Elicit Chemo-Immunotherapy against Malignant Pleural Effusion via Inhibition of OCT4/M-CSF Signaling Pathway.
You H, Li LG, Xiao CY, Wang X, Kong C, Leng F, Bai XF, Han N, Li TF, Wang MF
Molecular pharmaceutics 2026 May 4;23(5):3131-3145
Molecular pharmaceutics 2026 May 4;23(5):3131-3145
Ion interference induced by Ca-Mn nanoplatform enhances ferroptosis and promotes immune response for osteosarcoma treatment.
Zhang M, Wang Q, Li C, Chen M, Wang C, Wang Z, Xia T, Yi C, Shi S
Journal of advanced research 2026 Mar;81:823-836
Journal of advanced research 2026 Mar;81:823-836
Vaccination of mice with Trichinella spiralis serine proteinase enhanced gut epithelial barrier and elicited a high protective immunity.
Wu JY, Zhang XZ, Zhang R, Zhang Y, Liu RD, Zhang X, Long SR, Wang ZQ, Cui J
PLoS neglected tropical diseases 2026 Mar;20(3):e0014161
PLoS neglected tropical diseases 2026 Mar;20(3):e0014161
Mesenchymal Stem Cell-Derived Apoptotic Micro-Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis.
Liu H, Ouyang Y, Wang B, Zhang X, Guan Y, He R, Cui Y, Wang J, Yao Q, Tan Y, Peng X, Xiong X, Wang S, Li D, Cheng H, Su T, Fu X, Zhao J, Yu M, Wang Y, Peng J, Wang Y
Advanced healthcare materials 2026 Mar;15(10):e04087
Advanced healthcare materials 2026 Mar;15(10):e04087
Mechanically Preconditioned Biomimetic Gradient Scaffold for Tendon-to-Bone Regeneration in a Rabbit Rotator Cuff Tear Model.
Chen Y, Li Y, Aili D, Li J, Zhang C, Zhao C, Liu Q
The American journal of sports medicine 2026 Mar 5;:3635465261428684
The American journal of sports medicine 2026 Mar 5;:3635465261428684
ZG16 represses tumor progression and M2 polarization of tumor-associated macrophages in hepatocellular carcinoma by promoting ubiquitination and degradation of SNX9 via binding to ITCH.
Meng H, Wang Z, Wang L, Fang X, Li H, Ma W, Ding Y, Nan M, Meng Y, Li L, Li Y, Chen K, Zhang M
Hepatology international 2026 Mar 4;
Hepatology international 2026 Mar 4;
Repurposing dronedarone induces ferroptosis through GPX4 inactivation and degradation in pancreatic cancer.
Gu Y, Wang Y, Liu G, Cui R, Ma C, Wang J, Gao X, Zhao Y, Li Y
Journal of experimental & clinical cancer research : CR 2026 Mar 14;45(1)
Journal of experimental & clinical cancer research : CR 2026 Mar 14;45(1)
Integrative network toxicology and single-cell transcriptomics reveal TP53 as a key mediator of PCBs-induced microglial dysfunction in diabetic retinopathy.
Zhou M, Huang X, Wang L, Zhou Y, Chen Z, Wang L
Ecotoxicology and environmental safety 2026 Mar 1;312:119946
Ecotoxicology and environmental safety 2026 Mar 1;312:119946
AICAR improves depression-like behaviors and is associated with hippocampal AMPK activation and modulation of neurogenesis and neuroinflammation in a microbiota disruption model.
Takahashi K, Kurokawa K, Kawaguchi R, Takeda H, Tsuji M
Neurochemistry international 2026 Jun;196:106152
Neurochemistry international 2026 Jun;196:106152
The PTBP1-EZH2-DOCK2 axis promotes M1 microglial polarization and exacerbates neuronal apoptosis following spinal cord injury.
Sha C, Pan F, Liu X, Wang Z, Dai H, Huang K
Journal of orthopaedic translation 2026 Jan;56:101016
Journal of orthopaedic translation 2026 Jan;56:101016
Immunomodulatory mesoporous bioactive glass/interleukin-4 nanocomplex promotes bone regeneration.
Wang N, Chen Y, Cai Y, Liao L, Wang J, Wei J
International journal of biological macromolecules 2026 Jan;339(Pt 1):149869
International journal of biological macromolecules 2026 Jan;339(Pt 1):149869
Daucosterol ameliorates acute inflammation and fibrosis following myocardial infarction via regulation of the ZBTB16 protein.
Sheng S, Wu P, Wu C, Su H, Guo Z, Wang R, Li J, Duan Y, Zhang S, Ma L
British journal of pharmacology 2026 Jan;183(2):313-332
British journal of pharmacology 2026 Jan;183(2):313-332
Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug-Releasing Capability for the Programmable Repair of Spinal Cord Injury.
Wei Z, Huang S, Zhang W, Wen J, Zhou X, He W, Yang X, Wang H, Zhai G, Shi B, Jin L, Wang D, Feng S, Ye L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(6):e10976
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(6):e10976
Study on the role and mechanism of the IL-10-IRF-8 signaling pathway in bone marrow mesenchymal stem cell therapy for pain in CCD rats.
Yang Y, Wang M, Guo S, Feng Y, Zhang Y, Yue S
Molecular pain 2026 Jan-Dec;22:17448069261432034
Molecular pain 2026 Jan-Dec;22:17448069261432034
Taurine-loaded covalent organic frameworks for alleviating post-radiation bone regeneration disorder.
Chen H, Yang X, Ruan H, Wang X, Zheng M, Zeng G, He Y
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114492
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114492
TWEAK exacerbates allergic conjunctivitis via PKM2-dependent NF-κB activation and macrophage M1 polarization.
Yang Y, Zhang Y, Fu J, Yin X
Cellular signalling 2026 Feb;138:112264
Cellular signalling 2026 Feb;138:112264
DCC-2036 induces repolarization of TAMs to M1 type and enhances CD8(+) T cell immunity in TNBC.
Liang Y, Zeng Q, Xiao M, Li P, He R, Chen Z, Liu J, Cao J, Li J, Yin L, Zhong J, Chen X, Feng J, He J, Chen X, Zu X, Shen Y
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 4;34(2):985-1008
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 4;34(2):985-1008
Framework nucleic acid-based hydrogel for sequential immune regulation and endogenous TGF-β1 capture in wound healing.
Yin W, Yang Y, Yue Z, Wang R, Bai L, Lin Y, Chen X, Cai X
Biomaterials 2026 Apr;327:123780
Biomaterials 2026 Apr;327:123780
Kakkalide promotes spinal cord injury repair by regulating microglial M2 polarization via mitophagy.
You T, Dai B, Ding X, He Z, Peng J, Tao S, Ye L, Song T, Fan Z, Chen N
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157985
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157985
Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds.
Lu L, Xiong Y, Liao J, Zhou J, Wang G, Qin Y, Zhang S, Zhao Y, Zhong X, Wang M, Zha K, Al-Smadi F, Liu G, Zhao Y, Mi B
Cell reports. Medicine 2026 Apr 21;7(4):102714
Cell reports. Medicine 2026 Apr 21;7(4):102714
CAR-M2 immunotherapy resolves renal fibrosis via revascularization and apoptosis of profibrotic Cxcr2(+) endothelial cells.
Zhao W, Zhou X, Zhao X, Tian H, Su Y, Zhao S, Liu M, Zhang Q, Chen L, Li X, Liu D, Li J, Li L, Wang Y, Li X, Yan J, Chen W, Liu B, Zhu C, Zeng W
Cell reports. Medicine 2026 Apr 21;7(4):102698
Cell reports. Medicine 2026 Apr 21;7(4):102698
eNAMPT/Ac-STAT3/DIRAS2 Axis Promotes Development and Cancer Stemness in Triple-Negative Breast Cancer by Enhancing Cytokine Crosstalk Between Tumor-Associated Macrophages and Cancer Cells.
Zhang L, Wang L, Xu Z, Zhang X, Guan S, Liu Z, Gu S, Zhao L, Bai W, Li T, Zhao X
International journal of biological sciences 2025;21(5):2027-2047
International journal of biological sciences 2025;21(5):2027-2047
Tumor-associated macrophages drive heterogenetic CD10(High) cancer stem cells to implement tumor-associated neutrophils reprogramming in oral squamous cell carcinoma.
You Y, Du Z, Tian Z, Li S, Yu F, Xiao M, He Y, Wang Y
International journal of biological sciences 2025;21(3):1110-1126
International journal of biological sciences 2025;21(3):1110-1126
Single-cell transcriptomic analysis reveals the association of Ccl6+Ccr2+Arg1+ macrophages with renal interstitial fibrosis in AKI.
Zheng X, Wang J, Chen W, Xu Q, Xu T, Chen L
PloS one 2025;20(9):e0332026
PloS one 2025;20(9):e0332026
TGF-β-Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization.
Ma W, Ma Y, Bai Y, Guo C, Zhang Q, Su X
Open medicine (Warsaw, Poland) 2025;20(1):20251279
Open medicine (Warsaw, Poland) 2025;20(1):20251279
Modified Sijunzi Decoction Inhibits Pancreatic Cancer Progression and Improves Immune Suppression: Network Pharmacology and Experimental Validation.
Zhang Y, Ruan L, Li X, Si W, Yang P, Ba H, Chen Z
Drug design, development and therapy 2025;19:8949-8966
Drug design, development and therapy 2025;19:8949-8966
ZnO NPs Attenuate LPS-Induced Inflammation in RAW264.7 Macrophages by Inhibiting NF-κB and JAK1-STAT1/STAT3 Pathways and Reducing ROS.
Tang H, Zhang L, Deng C, Li Y, Ren G, Sun Z, Chang L, Xu M, Xiao D, Zhang H
Journal of inflammation research 2025;18:14075-14096
Journal of inflammation research 2025;18:14075-14096
Anti atherosclerosis effect and mechanism of a novel curcumin analogue CACN136: regulating macrophage M1/M2 polarization and lipid metabolism.
Zhao Q, Zhong Y, Li Z, Tang J, Pi C, Zheng W, Shi P, Zuo Y, Jiang J, Yang Y, Chu S, Wei Y, Zhao L
Frontiers in pharmacology 2025;16:1632647
Frontiers in pharmacology 2025;16:1632647
GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.
Cheng Y, Zheng G, Huang H, Ni J, Zhao Y, Sun Y, Chang Y, Liu S, He F, Li D, Guo Y, Miao Y, Xu M, Wang D, Zhang Y, Hua Y, Yang S, Fan G, Ma C
Theranostics 2025;15(10):4345-4367
Theranostics 2025;15(10):4345-4367
Extracellular vesicles derived from irradiated oral squamous cell carcinoma cells inhibits M2 macrophage polarization by the miR-198-5p/MYD88 axis.
Du X, Duan M, Zhang Y, Li R
International journal of radiation biology 2025;101(11):1117-1128
International journal of radiation biology 2025;101(11):1117-1128
Exogenous M2 Macrophage-Loaded Scaffolds Promote Early Periodontal Regeneration by Improving Osteogenic Differentiation, Cell Homing, and Angiogenesis.
Liao Z, Liang L, Fang H, Cui Y, Liang C, Huang G, Dai Z, Song Z, Yang H, Huang J
Advanced healthcare materials 2025 Sep;14(25):e2501428
Advanced healthcare materials 2025 Sep;14(25):e2501428
Phlorizin Alleviates Depression-like Behaviors via Gut Microbiota Reprogramming-Induced Methionine to Inhibit Neuroinflammation in Mice Hippocampus.
Li L, Chen J, Zhang X, Zhang X, Fu Y, Jiang H, Yin T, Zhang Y, Li X, Hu M, Lu Y
Pharmaceuticals (Basel, Switzerland) 2025 Sep 17;18(9)
Pharmaceuticals (Basel, Switzerland) 2025 Sep 17;18(9)
FPR2 Agonism Attenuates Restenosis by Mitigating Neointimal Hyperplasia via ELOVL6.
Zhang Q, Zha Y, Wang X, Zhao P, Woodman OL, Zhou M, Chen Y, Zhou X, Qin CX
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e71020
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e71020
Co-assembled polypeptides-adsorbing bridge molecules to enhance macrophage efferocytosis for the resolution of periodontitis inflammation.
Li B, Liang F, Gao Z, Zhou X, Zheng D, Zhang X, Sun M, Yan X, Li W, Wang Y, Lu X, Wu L, Sun X, Zhang H, Xu J, Wang Q
Acta biomaterialia 2025 Oct 1;205:601-615
Acta biomaterialia 2025 Oct 1;205:601-615
INHBA, transcriptionally activated by SPI1, facilitates gastric cancer progression by inducing macrophage recruitment and M2 polarization via activating the TGF-β signaling to increase CCL2.
Zhang F, Zhou C, Wang X, Liu Y, Hou Y, Niu L
Pathology, research and practice 2025 May;269:155920
Pathology, research and practice 2025 May;269:155920
Orally Deliverable Iron-Ceria Nanotablets for Treatment of Inflammatory Bowel Disease.
Baik S, Kim H, Lee Y, Kang T, Shin K, Song C, Park OK, Kang B, Lee N, Kim D, Choi SH, Kim SH, Soh M, Hyeon T, Kim CK
Advanced healthcare materials 2025 Mar;14(8):e2401994
Advanced healthcare materials 2025 Mar;14(8):e2401994
Excessive MYC Orchestrates Macrophages induced Chromatin Remodeling to Sustain Micropapillary-Patterned Malignancy in Lung Adenocarcinoma.
Song X, Pan Z, Zhang Y, Yang W, Zhang T, Wang H, Chen Y, Yu X, Ding H, Li R, Ge P, Xu L, Dong G, Jiang F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2403851
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2403851
Genetically Programmed Single-Component Protein Hydrogel for Spinal Cord Injury Repair.
Wei Y, Zhou X, Li Z, Liu Q, Ding H, Zhou Y, Yin RF, Zheng L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2405054
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2405054
Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model.
Ding X, Chen C, Zhao H, Dai B, Ye L, Song T, Huang S, Wang J, You T
Neural regeneration research 2025 Mar 1;20(3):858-872
Neural regeneration research 2025 Mar 1;20(3):858-872
P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin-Dependent Mitophagy After Spinal Cord Injury.
Lin J, Sun Y, Huang H, Yu C, Kuang W, Wang Y, Zhu L
Molecular neurobiology 2025 Jun;62(6):7054-7074
Molecular neurobiology 2025 Jun;62(6):7054-7074
Activation of GPER1 alleviates white matter injury by promoting microglia M2 polarization through EGFR/Stat3 pathway in intracerebral hemorrhage mice.
Zhang X, Mao J, Li H, Zhang C, Ge H, Zhong J
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jun;34(6):108315
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jun;34(6):108315
Enhanced inhibition of neuronal ferroptosis and regulation of microglial polarization with multifunctional traditional Chinese medicine active ingredients-based selenium nanoparticles for treating spinal cord injury.
Mai L, Liu J, Wu H, Wang H, Lin Z, Rao S, Sun W, Tan A, Lin Y, Chen B
Materials today. Bio 2025 Jun;32:101758
Materials today. Bio 2025 Jun;32:101758
K(+)-H(+) coupling strategy for immune regulation and bone defect repair.
Hu L, Yang K, Chen Y, Wang H, Fu Z, Jiang L, Xu J, Tian H, Zhu Y, Dai Z, Li Y, Chen X, Lin X, Chen P, Gu C, Fan S
Materials today. Bio 2025 Jun;32:101744
Materials today. Bio 2025 Jun;32:101744
Myeloid-specific deficiency of group VIA calcium-independent phospholipase A2 preconditions myeloid cells for injury resolution after acetaminophen exposure.
Xu F, Jansakun C, Li G, Biswas U, Poschet G, Staffer S, Tuma-Kellner S, Nakchbandi I, Merle U, Chamulitrat W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jun;187:118146
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jun;187:118146
Exploring the Unique Extracellular Matrix Composition of Acomys as a Potential Key to Resisting Fibrosis.
Dill MN, Turner Z, Kapuscinska PW, Heiden K, Basso KB, Simmons CS, Moore E
ACS biomaterials science & engineering 2025 Jun 9;11(6):3616-3633
ACS biomaterials science & engineering 2025 Jun 9;11(6):3616-3633
Construction of cartilaginous organoids based on cartilage extracellular matrix microcarriers to promote articular cartilage regeneration through immune regulation.
Jiang H, Liu W, Chen J, Tian Y, Jia Z, Wu Y, Guan Y, Chen L, Xu W, Meng H, Xiong Y, Ye J, Huang C, He R, Wang S, Ding Y, Fan W, Yang Y, Peng J, Wang A
Journal of orthopaedic translation 2025 Jul;53:82-98
Journal of orthopaedic translation 2025 Jul;53:82-98
Immune-modulated adhesive hydrogel for enhancing osteochondral graft adhesion and cartilage repair.
Zhou J, Ji X, Xue Y, Yang W, Zhong G, Zhou Z, Chen X, Lei Z, Lu T, Zhang Y, Liu J, Ma L
Bioactive materials 2025 Jul;49:23-38
Bioactive materials 2025 Jul;49:23-38
Activation of Hippocampal ACE2 Prevents the Dysbiosis-induced Depression-like Behavior in Mice by Enhanced Neurogenesis and Neuroprotection via Mas Receptor.
Takahashi K, Nakagawasai O, Kurokawa K, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jul 18;20(1):71
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jul 18;20(1):71
Exogenous arginine differentially regulates inflammatory cytokine and inducible nitric oxide synthase expression in macrophages.
Stayer K, Pathan S, Biswas A, Li H, Zhu Y, Lam FW, Marini J, Thevananther S
ImmunoHorizons 2025 Jul 14;9(8)
ImmunoHorizons 2025 Jul 14;9(8)
Ultrasound-Triggered Nanogel Boosts Chemotherapy and Immunomodulation in Colorectal Cancer.
Cui R, Zhou J, Yang W, Chen Y, Chen L, Tan L, Zhang F, Liu G, Yu J
ACS applied materials & interfaces 2025 Jan 8;17(1):211-221
ACS applied materials & interfaces 2025 Jan 8;17(1):211-221
Danhong injection modulates microglial polarization and neuroinflammation via the JUNB/NF-κB pathway in ischemic stroke.
Xie M, Huang H, Lu Y, Chen L, Wang S, Xian M
Journal of ethnopharmacology 2025 Jan 31;340:119247
Journal of ethnopharmacology 2025 Jan 31;340:119247
Gut commensal bacteria Parabacteroides goldsteinii-derived outer membrane vesicles suppress skin inflammation in psoriasis.
Su D, Li M, Xie Y, Xu Z, Lv G, Jiu Y, Lin J, Chang CJ, Chen H, Cheng F
Journal of controlled release : official journal of the Controlled Release Society 2025 Jan 10;377:127-145
Journal of controlled release : official journal of the Controlled Release Society 2025 Jan 10;377:127-145
KAT3B-mediated succinylation of DERL3 suppresses osteogenic differentiation by promoting M1/M2 macrophage polarization.
Yu B, Qiao Y, Sun X, Yin Y
Biochemical pharmacology 2025 Feb;232:116724
Biochemical pharmacology 2025 Feb;232:116724
Electroacupuncture normalized tumor vasculature by downregulating glyoxalase-1 to polarize tumor-associated macrophage to M1 phenotype in triple-negative breast cancer.
Qi X, Lian Y, Fan Z, Wang H, Jiang H, He M, Li L, Huang J, Wan Y
International immunopharmacology 2025 Feb 6;147:113988
International immunopharmacology 2025 Feb 6;147:113988
Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury.
Chen X, Wang B, Al Mamun A, Du K, Wang S, Hu Q, Chen X, Lu Y, Du A, Wu Y, Shao J, Wang S, Jiang C, Zhou K, Hu S, Xiao J
Journal of nanobiotechnology 2025 Feb 28;23(1):152
Journal of nanobiotechnology 2025 Feb 28;23(1):152
ITIH5-mediated fibroblast/macrophage crosstalk exacerbates cardiac remodelling after myocardial infarction.
Wu Y, Meng L, Zhan S, Li M, Huang J, Chen X, Chen L, Gao X, Chen H, Chen H, Zhong Y, Xu L, Xu Y
Journal of translational medicine 2025 Feb 24;23(1):224
Journal of translational medicine 2025 Feb 24;23(1):224
Anti-Neuroinflammatory Eremophilane Sesquiterpenoids from Marine-Derived Fungus Phoma sp. DXH009.
Yang G, Qin M, Chen M, Shi Y, Liu S, Rao Y, Huang L, Fu Y
Marine drugs 2025 Feb 20;23(3)
Marine drugs 2025 Feb 20;23(3)
Inflammatory memory-activated biomimetic nanovesicles regulate neutrophil plasticity and metabolic reprogramming for rapid diabetic wound healing via targeting miR-193a-5p/TLR4/JNK/P38 MAPK pathways.
Fan Y, Yang J, Xie Y, Yang X, Zhu H, Liu Y, Xia Z, Ji S, Yang R
Journal of nanobiotechnology 2025 Feb 17;23(1):115
Journal of nanobiotechnology 2025 Feb 17;23(1):115
Inhibition of Macrophage Activation by Minocycline Attenuates CCI-Induced Neuropathic Pain.
Ji YZ, Lin ZH, Liao CX, Wang Q, Chen FY, Su WF, Zhao YY, Chen G, Wei ZY
Inflammation 2025 Dec;48(6):3912-3926
Inflammation 2025 Dec;48(6):3912-3926
Farrerol confers neuroprotection in spinal cord injury by regulating macrophages/microglia polarization through the JAK2/STAT3 pathway.
Chen Y, Ren L, Xia J, Li B, Yang Y, Li J, Tao L, Song X, Lü H, Hu J
Experimental neurology 2025 Dec;394:115448
Experimental neurology 2025 Dec;394:115448
4'-hydroxychalcone nanofiber hydrogel dressing promotes diabetic chronic wound healing by regulating macrophage polarization via the TLR/IL-17/TNF signaling pathway.
Li HY, Li MY, Cui CX, Yu HM, Sun Y, Yang JJ, Li YR, Li YQ, Liu TM
Materials today. Bio 2025 Dec;35:102474
Materials today. Bio 2025 Dec;35:102474
ASFV activates STAT3 to induce proviral M2 macrophage polarization.
Chen Y, Chen H, Zhang W, Lv P, Wang Z, Liao H, Wei K, He Q, Cui M
Veterinary microbiology 2025 Dec;311:110733
Veterinary microbiology 2025 Dec;311:110733
Transglutaminase-2 Promotes Microglial Synaptic Phagocytosis and Ameliorates Epileptic Seizures by Inhibiting ABCA1 Ubiquitination.
Zhou Z, Wang X, Yang J, Qin J, Feng B, Qin Q, Tian J, Luo Z, Yang X, Huang H, Xu X, Li J, Xu Z, Yu C, Zhang H
CNS neuroscience & therapeutics 2025 Dec;31(12):e70725
CNS neuroscience & therapeutics 2025 Dec;31(12):e70725
A Novel TLR4 Inhibitor DB03476 Rescued Renal Inflammation in Acute Kidney Injury Model.
Zhang YF, Ma YX, Wei SJ, Yang B, Ji YH, Qi ZX, Shi XY, Zhang LL, Fan XZ, Yang XJ
International journal of molecular sciences 2025 Dec 31;27(1)
International journal of molecular sciences 2025 Dec 31;27(1)
Sirtuin 3 promotes osteogenic differentiation of bone marrow mesenchymal stem cells by regulating macrophage polarization under high glucose.
Lin L, Ren Y, Wang X, Liang H, Yao Q
Scientific reports 2025 Dec 25;16(1):3515
Scientific reports 2025 Dec 25;16(1):3515
tsRNA-10105-enriched migrasomes mediate hepatocellular carcinoma immunosuppressive microenvironment by inducing M2 Macrophage polarization.
Pan L, Zhou R, Wen Z, Lin Y, Cai H, Lin C, Xu X, Ruan L, Zeng Y, Zhang H, Zhou Y, Hu X
Experimental cell research 2025 Dec 1;453(2):114729
Experimental cell research 2025 Dec 1;453(2):114729
Baicalein attenuates metabolic dysfunction-associated steatohepatitis by regulating macrophage ferroptosis through nuclear factor (erythroid-derived 2)-like 2 pathway.
Wang Y, Zhao Y, Zhao W, Chen H, Cao Z, Li H, Tang Y, Zhu X, Yao P
Free radical biology & medicine 2025 Dec 1;240:238-252
Free radical biology & medicine 2025 Dec 1;240:238-252
Black phosphorus nanosheets promote neuronal differentiation of neural stem cells through adhesion and pinocytosis for spinal cord injury repair.
Chen L, Shi L, Wei T, Liu H, Wang Z, Wang H, Li N, Feng S
Acta biomaterialia 2025 Aug;202:529-544
Acta biomaterialia 2025 Aug;202:529-544
Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3-Regulated HIF1A/HMOX1 Signaling Pathway.
Liang Z, Liu J, Gou Y, Wang H, Li Z, Cao Y, Zhang H, Bai R, Zhang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e08220
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e08220
Astrocytic ET-1 System Determines Microglia Phenotype Following Spinal Cord Injury.
He B, Xu S, Li M, Li H, Li S, Niu L, Song H, Cai R, Zhou Y, Cao Z, Wang Y, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e07215
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e07215
Mechanistic Study of Jaceosidin in Regulating Secondary Inflammation After Spinal Cord Injury in Mouse by Inhibiting PKM2 Activity.
Dai B, Fan Z, Chen R, Weng X, Fang R
Neuromolecular medicine 2025 Aug 6;27(1):57
Neuromolecular medicine 2025 Aug 6;27(1):57
Piezo1 promotes colitis progression by modulating the Nrf2/NF-κB/NLRP3 signaling pathway.
Zhou P, Zeng L, Ma K, Li B, Zhang Y, Zhong Z, Wan Y, Tao K, Zhang P
Biochemical pharmacology 2025 Aug 29;242(Pt 1):117293
Biochemical pharmacology 2025 Aug 29;242(Pt 1):117293
Multiomics integration analysis identifies tumor cell-derived MIF as a therapeutic target and potentiates anti-PD-1 therapy in osteosarcoma.
Chen W, Liao Y, Yao H, Zou Y, Fang J, Zhang J, Guo Z, Tu J, Chen J, Huo Z, Wen L, Xie X
Journal for immunotherapy of cancer 2025 Aug 22;13(8)
Journal for immunotherapy of cancer 2025 Aug 22;13(8)
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Fang M, Lu L, Lou J, Ou J, Yu Q, Tao X, Zhu J, Lin Z
Molecular neurobiology 2025 Apr;62(4):4743-4768
Molecular neurobiology 2025 Apr;62(4):4743-4768
Inhibition of glutaminase 1 reduces M1 macrophage polarization to protect against monocrotaline-induced pulmonary arterial hypertension.
Chen X, Li L, Deng Y, Liao J, Meng H, Liang L, Hu J, Xie D, Liang G
Immunology letters 2025 Apr;272:106974
Immunology letters 2025 Apr;272:106974
A Smart MMP-9-responsive Hydrogel Releasing M2 Macrophage-derived Exosomes for Diabetic Wound Healing.
Meng H, Su J, Shen Q, Hu W, Li P, Guo K, Liu X, Ma K, Zhong W, Chen S, Ma L, Hao Y, Chen J, Jiang Y, Li L, Fu X, Zhang C
Advanced healthcare materials 2025 Apr;14(10):e2404966
Advanced healthcare materials 2025 Apr;14(10):e2404966
Mannose-Glycated Metal-Phenolic Microcapsules Orchestrate Phenotype Switch of Macrophages for Boosting Tumor Immunotherapy.
Tan X, Sheng R, Li W, Tao Y, Liu Z, Yang N, Hashmi SS, Feng F, Liu F, Ge L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2415565
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2415565
Fermented Cordyceps Powder alleviates silica-induced inflammation and fibrosis by inhibiting M1 macrophage polarization via the HMGB1-TLR4-NF-κB pathway.
Pu S, Meng X, Shi Y, Huang N, Zhang C, Pang A, Shao H, Jia Q
Journal of ethnopharmacology 2025 Apr 9;345:119631
Journal of ethnopharmacology 2025 Apr 9;345:119631
Genetically Modified Hepatocytes Targeting Bilirubin and Ammonia Metabolism for the Construction of Bioartificial Liver System.
Wang K, Zhu Y, Li M, Yang Y, Zuo D, Sheng J, Zhang X, Wang W, Zhou P, Feng M
Biomaterials research 2024;28:0043
Biomaterials research 2024;28:0043
Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.
Hu Y, Li Y, Xiong H, Zhang Y, Wang F, Zhuo W, Zeng Z, Zhao Y, Wang H, Hu P, Han S, Huang Y, Lv G, Zhao G
International journal of biological sciences 2024;20(11):4341-4363
International journal of biological sciences 2024;20(11):4341-4363
FoxO1-Overexpressed Small Extracellular Vesicles Derived from hPDLSCs Promote Periodontal Tissue Regeneration by Reducing Mitochondrial Dysfunction to Regulate Osteogenesis and Inflammation.
Niu Q, Lin C, Yang S, Rong S, Wei J, Zhao T, Peng Y, Cheng Z, Xie Y, Wang Y
International journal of nanomedicine 2024;19:8751-8768
International journal of nanomedicine 2024;19:8751-8768
Myeloid Deletion of Cdc42 Protects Liver From Hepatic Ischemia-Reperfusion Injury via Inhibiting Macrophage-Mediated Inflammation in Mice.
He J, Tang MY, Liu LX, Kong CX, Chen W, Wang L, Zhi SB, Sun HW, Huang YC, Chen GY, Xin HB, Deng KY
Cellular and molecular gastroenterology and hepatology 2024;17(6):965-981
Cellular and molecular gastroenterology and hepatology 2024;17(6):965-981
Protective effects of berbamine against arginase-1 deficiency-induced injury in human brain microvascular endothelial cells.
Wei X, Li W, Chen Z, Chen J, Chen Y, Cai J, Lin H
Frontiers in pharmacology 2024;15:1497973
Frontiers in pharmacology 2024;15:1497973
Inhibition of PTEN promotes osteointegration of titanium implants in type 2 diabetes by enhancing anti-inflammation and osteogenic capacity of adipose-derived stem cells.
Zhang G, Song S, Chen Z, Liu X, Zheng J, Wang Y, Chen X, Song Y
Frontiers in bioengineering and biotechnology 2024;12:1358802
Frontiers in bioengineering and biotechnology 2024;12:1358802
Propionate-producing engineered probiotics ameliorated murine ulcerative colitis by restoring anti-inflammatory macrophage via the GPR43/HDAC1/IL-10 axis.
Kang G, Wang X, Gao M, Wang L, Feng Z, Meng S, Wu J, Zhu Z, Gao X, Cao X, Huang H
Bioengineering & translational medicine 2024 Sep;9(5):e10682
Bioengineering & translational medicine 2024 Sep;9(5):e10682
3D printing of interferon γ-preconditioned NSC-derived exosomes/collagen/chitosan biological scaffolds for neurological recovery after TBI.
Chen C, Chang ZH, Yao B, Liu XY, Zhang XW, Liang J, Wang JJ, Bao SQ, Chen MM, Zhu P, Li XH
Bioactive materials 2024 Sep;39:375-391
Bioactive materials 2024 Sep;39:375-391
Ocotillol-Type Pseudoginsenoside-F11 Alleviates Lipopolysaccharide-Induced Acute Kidney Injury through Regulation of Macrophage Function by Suppressing the NF-κB/NLRP3/IL-1β Signaling Pathway.
Wang Y, Zhang J, Yang Z, Li C, Zhang C, Sun S, Jiao Z, Che G, Gao H, Liu J, Li J
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20496-20512
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20496-20512
A Hirsutella sinensis Alcohol Extract Exerts Bidirectional Immunoregulatory Effects by Regulating Macrophage Polarization.
Wang X, Li Q, Han D, Xie F, Wang J, Li Y, Cheng C, Chu Y, Liu X, Dong Q, Yu Y, Luo Z, Guo J, Zhang Z, Wang Y
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20432-20443
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20432-20443
YIGSR, A Laminin-Derived Peptide, Dictates a Concentration-Dependent Impact on Macrophage Phenotype Response.
Jha A, Moore E
Cellular and molecular bioengineering 2024 Oct;17(5):423-440
Cellular and molecular bioengineering 2024 Oct;17(5):423-440
Leukocyte infiltration and cross-talk with cardiomyocytes exploit intracellular stress pathways in dilated cardiomyopathy of idiopathic origin.
Talukdar D, Haldar AK, Kumar S, Dastidar R, Basu A, Roy A, Sarkar S, Dey S, Sikder K
Molecular biology reports 2024 Oct 24;51(1):1090
Molecular biology reports 2024 Oct 24;51(1):1090
Crystalline silica-induced endoplasmic reticulum stress promotes the pathogenesis of silicosis by augmenting proinflammatory interstitial pulmonary macrophages.
Yuan H, He Y, Zhang Y, Min H, Chen J, Li C
The Science of the total environment 2024 Oct 10;946:174299
The Science of the total environment 2024 Oct 10;946:174299
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
Fang M, Yu Q, Ou J, Lou J, Zhu J, Lin Z
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
TREM1 promotes neuroinflammation after traumatic brain injury in rats: Possible involvement of ERK/cPLA2 signalling pathway.
Zhang C, Jiang F, Liu S, Ni H, Feng Z, Huang M, Lu Y, Qian Y, Shao J, Rui Q
Neuroscience 2024 Nov 22;561:74-86
Neuroscience 2024 Nov 22;561:74-86
Gastrodin Regulates PI3K/AKT-Sirt3 Signaling Pathway and Proinflammatory Mediators in Activated Microglia.
Zuo HJ, Wang PX, Ren XQ, Shi HL, Shi JS, Guo T, Wan C, Li JJ
Molecular neurobiology 2024 May;61(5):2728-2744
Molecular neurobiology 2024 May;61(5):2728-2744
Effect of CTLA-4 Inhibition on Inflammation and Apoptosis After Spinal Cord Injury.
Mao W, Jiang F, Zhu C, Liu J, Lu Z, Qian Y, Xiao J
Neurochemical research 2024 May;49(5):1359-1372
Neurochemical research 2024 May;49(5):1359-1372
Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction.
Takahashi K, Tsuji M, Nakagawasai O, Katsuyama S, Miyagawa K, Kurokawa K, Mochida-Saito A, Takeda H, Tadano T
Neurochemistry international 2024 May;175:105723
Neurochemistry international 2024 May;175:105723
Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.
Chen X, Wang B, Zhou Y, Wu X, Du A, Al Mamun A, Xu Y, Wang S, Jiang C, Xie L, Zhou K, Hu S, Xiao J
Advanced healthcare materials 2024 May;13(12):e2303462
Advanced healthcare materials 2024 May;13(12):e2303462
Photothermal and Photocatalytic Glycol Chitosan and Polydopamine-Grafted Oxygen Vacancy Bismuth Oxyiodide (BiO(1-x) I) Nanoparticles for the Diagnosis and Targeted Therapy of Diabetic Wounds.
Kong J, Ma S, Chu R, Liu J, Yu H, Mao M, Ge X, Sun Y, Wang Y
Advanced materials (Deerfield Beach, Fla.) 2024 Mar;36(11):e2307695
Advanced materials (Deerfield Beach, Fla.) 2024 Mar;36(11):e2307695
The Effect of Salvianolic Acid A on Tumor-Associated Macrophage Polarization and Its Mechanisms in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Tang C, Jiang ST, Li CX, Jia XF, Yang WL
Molecules (Basel, Switzerland) 2024 Mar 26;29(7)
Molecules (Basel, Switzerland) 2024 Mar 26;29(7)
Human amniotic MSCs-mediated anti-inflammation of CD206(hi)IL-10(hi) macrophages alleviates isoproterenol-induced ventricular remodeling in mice.
Huang QM, Long YL, Wang JN, Wu J, Tang WL, Wang XY, Zhang ZH, Zhuo YQ, Guan XH, Deng KY, Xin HB
International immunopharmacology 2024 Mar 10;129:111660
International immunopharmacology 2024 Mar 10;129:111660
Astragaloside IV alleviates macrophage senescence and d-galactose-induced bone loss in mice through STING/NF-κB pathway.
Li M, Niu Y, Tian L, Zhang T, Zhou S, Wang L, Sun J, Wumiti T, Chen Z, Zhou Q, Ma Y, Guo Y
International immunopharmacology 2024 Mar 10;129:111588
International immunopharmacology 2024 Mar 10;129:111588
Laminin-derived peptide, IKVAV, modulates macrophage phenotype through integrin mediation.
Jha A, Moore E
Matrix biology plus 2024 Jun;22:100143
Matrix biology plus 2024 Jun;22:100143
Multifunctional Biodegradable Conductive Hydrogel Regulating Microenvironment for Stem Cell Therapy Enhances the Nerve Tissue Repair.
Xu C, Wu P, Yang K, Mu C, Li B, Li X, Wang Z, Liu Z, Wang X, Luo Z
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(23):e2309793
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(23):e2309793
Prednisone combined with Dihydroartemisinin attenuates systemic lupus erythematosus by regulating M1/M2 balance through the MAPK signaling pathway.
Chen Y, Tao T, Liang Z, Chen X, Xu Y, Zhang T, Zhou D
Molecular immunology 2024 Jun;170:144-155
Molecular immunology 2024 Jun;170:144-155
Increase in GPIHBP1 expression in advanced stage colorectal cancer indicates poor immune surveillance.
Gao M, Liao L, Lin Z, Hu X, Jia L, Gong W, Jia X
Translational cancer research 2024 Jun 30;13(6):2691-2703
Translational cancer research 2024 Jun 30;13(6):2691-2703
Exosome/antimicrobial peptide laden hydrogel wound dressings promote scarless wound healing through miR-21-5p-mediated multiple functions.
Yang Y, Zhang J, Wu S, Deng Y, Wang S, Xie L, Li X, Yang L
Biomaterials 2024 Jul;308:122558
Biomaterials 2024 Jul;308:122558
Injectable, Electroconductive, Free Radical Scavenging Silk Fibroin/Black Phosphorus/Glycyrrhizic Acid Nanocomposite Hydrogel for Enhancing Spinal Cord Repair.
Zhang B, Wang W, Gao P, Li X, Chen L, Lin Z, Chen H, Liang W, Kong Z, Lin D, Wu X, Zhang T
Advanced healthcare materials 2024 Jul;13(18):e2304300
Advanced healthcare materials 2024 Jul;13(18):e2304300
Silencing SPP1 in M2 macrophages inhibits the progression of castration-resistant prostate cancer via the MMP9/TGFβ1 axis.
Chen S, Deng B, Zhao F, You H, Liu Y, Xie L, Song G, Zhou Z, Huang G, Shen W
Translational andrology and urology 2024 Jul 31;13(7):1239-1255
Translational andrology and urology 2024 Jul 31;13(7):1239-1255
miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1.
Ou Z, Cheng Y, Ma H, Chen K, Lin Q, Chen J, Guo R, Huang Z, Cheng Q, Alaeiilkhchi N, Zhu Q, Huang Z, Jiang H
Journal of translational medicine 2024 Jul 15;22(1):659
Journal of translational medicine 2024 Jul 15;22(1):659
Microglial FoxO3a deficiency ameliorates ferroptosis-induced brain injury of intracerebral haemorrhage via regulating autophagy and heme oxygenase-1.
Wang R, Liang Z, Xue X, Mei H, Ji L, Wang B, Chen W, Gao C, Yuan S, Wu T, Qi H, Hu S, Yi L, Song Y, Liao R, Chen B
Journal of cellular and molecular medicine 2024 Jan;28(1):e18007
Journal of cellular and molecular medicine 2024 Jan;28(1):e18007
Extract of Astragali Radix and Solanum nigrum Linne regulates microglia and macrophage polarization and inhibits the growth and infiltration of C6 glioblastoma.
Shen M, Liu S, Wei Q, Zhang X, Wen S, Qiu R, Li Y, Fan H
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117067
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117067
Extracellular vesicles derived from monomeric α-synuclein-treated microglia ameliorate neuroinflammation by delivery of miRNAs targeting PRAK.
Li N, Huang Y, Wu Y, Wang Q, Ji P
Neuroscience letters 2024 Jan 1;818:137562
Neuroscience letters 2024 Jan 1;818:137562
Moluodan promotes DSS-induced intestinal inflammation involving the reprogram of macrophage function and polarization.
Zhao M, Qiao C, Cui Z, Zhang W, Yang S, Zhu C, Du F, Ning T, Xie S, Liu S, Li P, Xu J, Zhu S
Journal of ethnopharmacology 2024 Feb 10;320:117393
Journal of ethnopharmacology 2024 Feb 10;320:117393
Bromodomain containing 4 inhibition combats gastric precancerous lesions via modulating macrophage polarization.
Zhu L, Cai Q, Li G, Zou X
Tissue & cell 2024 Dec;91:102580
Tissue & cell 2024 Dec;91:102580
Sirt3-Mediated Opa1 Deacetylation Protects Against Sepsis-Induced Acute Lung Injury by Inhibiting Alveolar Macrophage Pro-Inflammatory Polarization.
Sun M, Li Y, Xu G, Zhu J, Lu R, An S, Zeng Z, Deng Z, Cheng R, Zhang Q, Yao Y, Wu J, Zhang Y, Hu H, Chen Z, Huang Q, Wu J
Antioxidants & redox signaling 2024 Dec;41(16-18):1014-1030
Antioxidants & redox signaling 2024 Dec;41(16-18):1014-1030
S100A9 Induces Macrophage M2 Polarization and Immunomodulatory Role in the Lesion Site After Spinal Cord Injury in Rats.
Lv J, Wang Z, Wang B, Deng C, Wang W, Sun L
Molecular neurobiology 2024 Aug;61(8):5525-5540
Molecular neurobiology 2024 Aug;61(8):5525-5540
Apilarnil exerts neuroprotective effects and alleviates motor dysfunction by rebalancing M1/M2 microglia polarization, regulating miR-155 and miR-124 expression in a rotenone-induced Parkinson's disease rat model.
Salama RM, Darwish SF, Yehia R, Eissa N, Elmongy NF, Abd-Elgalil MM, Schaalan MF, El Wakeel SA
International immunopharmacology 2024 Aug 20;137:112536
International immunopharmacology 2024 Aug 20;137:112536
Azithromycin regulates Mettl3-mediated NF-κB pathway to enhance M2 polarization of RAW264.7 macrophages and attenuate LPS-triggered cytotoxicity of MLE-12 alveolar cells.
Xu S, Xing J, Zheng L, Su H, Zou Y, Niu Y, Di H
International immunopharmacology 2024 Aug 20;137:112426
International immunopharmacology 2024 Aug 20;137:112426
Combined untargeted metabolomics and network pharmacology approaches to reveal the therapeutic role of withanolide B in psoriasis.
Li T, Gao S, Wei Y, Wu G, Feng Y, Wang Y, Jiang X, Kuang H, Han W
Journal of pharmaceutical and biomedical analysis 2024 Aug 1;245:116163
Journal of pharmaceutical and biomedical analysis 2024 Aug 1;245:116163
Renalase mediates macrophage-to-fibroblast crosstalk to attenuate pressure overload-induced pathological myocardial fibrosis.
Fu R, You N, Li R, Zhao X, Li Y, Li X, Jiang W
Journal of hypertension 2024 Apr 1;42(4):629-643
Journal of hypertension 2024 Apr 1;42(4):629-643
Investigation of anti-depression effects and potential mechanisms of the ethyl acetate extract of Cynomorium songaricum Rupr. through the integration of in vivo experiments, LC-MS/MS chemical analysis, and a systems biology approach.
Zhang X, Li L, Chen J, Hu M, Zhang Y, Zhang X, Lu Y
Frontiers in pharmacology 2023;14:1239197
Frontiers in pharmacology 2023;14:1239197
BMP7 Attenuates Neuroinflammation after Spinal Cord Injury by Suppressing the Microglia Activation and Inducing Microglial Polarization Via the STAT3 Pathway.
Wei X, Huang C, Chen K, Liu S, Wang M, Yang L, Wang Y
Neurochemical research 2023 Sep;48(9):2687-2700
Neurochemical research 2023 Sep;48(9):2687-2700
Salidroside ameliorated the pulmonary inflammation induced by cigarette smoke via mitigating M1 macrophage polarization by JNK/c-Jun.
Feng H, Zhang D, Yin Y, Kang J, Zheng R
Phytotherapy research : PTR 2023 Sep;37(9):4251-4264
Phytotherapy research : PTR 2023 Sep;37(9):4251-4264
CD73 inhibits titanium particle-associated aseptic loosening by alternating activation of macrophages.
Sun Z, Kang J, Yang S, Zhang Y, Huang N, Zhang X, Du G, Jiang J, Ning B
International immunopharmacology 2023 Sep;122:110561
International immunopharmacology 2023 Sep;122:110561
A multifunctional polydopamine/genipin/alendronate nanoparticle licences fibrin hydrogels osteoinductive and immunomodulatory potencies for repairing bone defects.
Shi W, Gao Y, Wu Y, Sun J, Xu B, Lu X, Wang Q
International journal of biological macromolecules 2023 Sep 30;249:126072
International journal of biological macromolecules 2023 Sep 30;249:126072
Critical contributions of protein cargos to the functions of macrophage-derived extracellular vesicles.
Liu B, Nguyen PL, Yu H, Li X, Wang H, Price J, Niu M, Guda C, Cheng X, Sun X, Moreau R, Ramer-Tait A, Naldrett MJ, Alvarez S, Yu J
Journal of nanobiotechnology 2023 Sep 28;21(1):352
Journal of nanobiotechnology 2023 Sep 28;21(1):352
Gd-EOB MRI for HCC subtype differentiation in a western population according to the 5(th) edition of the World Health Organization classification.
Auer TA, Halskov S, Fehrenbach U, Nevermann NF, Pelzer U, Mohr R, Hamm B, Schöning W, Horst D, Ihlow J, Geisel D
European radiology 2023 Oct;33(10):6902-6915
European radiology 2023 Oct;33(10):6902-6915
Autophagy suppression facilitates macrophage M2 polarization via increased instability of NF-κB pathway in hepatocellular carcinoma.
Gao Z, Li XG, Feng SR, Chen JF, Song K, Shi YH, Tang Z, Liu WR, Zhang X, Huang A, Luo XM, Zeng HY, Gao Q, Shi GM, Ke AW, Zhou J, Fan J, Fu XT, Ding ZB
International immunopharmacology 2023 Oct;123:110685
International immunopharmacology 2023 Oct;123:110685
Low-dose adropin stimulates inflammasome activation of macrophage via mitochondrial ROS involved in colorectal cancer progression.
Jia L, Liao L, Jiang Y, Hu X, Lu G, Xiao W, Gong W, Jia X
BMC cancer 2023 Oct 30;23(1):1042
BMC cancer 2023 Oct 30;23(1):1042
PROMOTING MITOCHONDRIAL DYNAMIC EQUILIBRIUM ATTENUATES SEPSIS-INDUCED ACUTE LUNG INJURY BY INHIBITING PROINFLAMMATORY POLARIZATION OF ALVEOLAR MACROPHAGES.
Sun M, Zeng Z, Xu G, An S, Deng Z, Cheng R, Yao Y, Wu J, Hu H, Huang Q, Wu J
Shock (Augusta, Ga.) 2023 Oct 1;60(4):603-612
Shock (Augusta, Ga.) 2023 Oct 1;60(4):603-612
IGF2BP3 drives gallbladder cancer progression by m6A-modified CLDN4 and inducing macrophage immunosuppressive polarization.
Qin J, Cui Z, Zhou J, Zhang B, Lu R, Ding Y, Hu H, Cai J
Translational oncology 2023 Nov;37:101764
Translational oncology 2023 Nov;37:101764
Dauricine regulates prostate cancer progression by inhibiting PI3K/AKT-dependent M2 polarization of macrophages.
Li M, Che N, Liu X, Xuan Y, Jin Y
Biochemical pharmacology 2023 Nov;217:115838
Biochemical pharmacology 2023 Nov;217:115838
The metabolite butyrate produced by gut microbiota inhibits cachexia-associated skeletal muscle atrophy by regulating intestinal barrier function and macrophage polarization.
Liu H, Xi Q, Tan S, Qu Y, Meng Q, Zhang Y, Cheng Y, Wu G
International immunopharmacology 2023 Nov;124(Pt B):111001
International immunopharmacology 2023 Nov;124(Pt B):111001
Ultrasound-Induced Gold Nanoparticle United with Acoustic Reprogramming of Macrophages for Enhanced Cancer Therapy.
Tang Q, Zhang F, Luo L, Duan Y, Zhu T, Ni Y, Wang Y, Qi H, Jiang S, Zhou J, Ma X, Zhang Y
ACS applied materials & interfaces 2023 Nov 8;15(44):50926-50939
ACS applied materials & interfaces 2023 Nov 8;15(44):50926-50939
TMEM16F may be a new therapeutic target for Alzheimer's disease.
Cui ZQ, Hu XY, Yang T, Guan JW, Gu Y, Li HY, Zhang HY, Xiao QH, Sun XH
Neural regeneration research 2023 Mar;18(3):643-651
Neural regeneration research 2023 Mar;18(3):643-651
Garlic-derived exosomes carrying miR-396e shapes macrophage metabolic reprograming to mitigate the inflammatory response in obese adipose tissue.
Bian Y, Li W, Jiang X, Yin F, Yin L, Zhang Y, Guo H, Liu J
The Journal of nutritional biochemistry 2023 Mar;113:109249
The Journal of nutritional biochemistry 2023 Mar;113:109249
Tongxinluo promotes endothelium-dependent arteriogenesis to attenuate diabetic peripheral arterial disease.
Gu JJ, Hou YL, Yan YH, Li J, Wei YR, Ma K, Wang XQ, Zhang JH, Wang DD, Li CR, Li DQ, Sun LL, Gao HL
World journal of diabetes 2023 Mar 15;14(3):234-254
World journal of diabetes 2023 Mar 15;14(3):234-254
Lacticaseibacillus casei CNRZ1874 supplementation promotes M1 alveolar macrophage activation and attenuates Mycoplasma pneumoniae pneumonia.
Zhang N, Zeng W, Du T, Wei H, Tian W, Meng Y, He G, Lei A, Zhu C
Journal of applied microbiology 2023 Mar 1;134(3)
Journal of applied microbiology 2023 Mar 1;134(3)
Targeting of Annexin A1 in Tumor-associated Macrophages as a therapeutic strategy for hepatocellular carcinoma.
Song Z, Wang X, Liu X, Luo Y, Qiu J, Yin A, Liu Y, Yi H, Xiao Z, Li A
Biochemical pharmacology 2023 Jul;213:115612
Biochemical pharmacology 2023 Jul;213:115612
Selenium-Doped Mesoporous Bioactive Glass Regulates Macrophage Metabolism and Polarization by Scavenging ROS and Promotes Bone Regeneration In Vivo.
Chen D, Liang Z, Su Z, Huang J, Pi Y, Ouyang Y, Luo T, Guo L
ACS applied materials & interfaces 2023 Jul 26;15(29):34378-34396
ACS applied materials & interfaces 2023 Jul 26;15(29):34378-34396
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.
Southwell N, Primiano G, Nadkarni V, Attarwala N, Beattie E, Miller D, Alam S, Liparulo I, Shurubor YI, Valentino ML, Carelli V, Servidei S, Gross SS, Manfredi G, Chen Q, D'Aurelio M
EMBO molecular medicine 2023 Jul 10;15(7):e16951
EMBO molecular medicine 2023 Jul 10;15(7):e16951
Arthritic Microenvironment Actuated Nanomotors for Active Rheumatoid Arthritis Therapy.
Xu C, Jiang Y, Wang H, Zhang Y, Ye Y, Qin H, Gao J, Dan Q, Du L, Liu L, Peng F, Li Y, Tu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(4):e2204881
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(4):e2204881
FNDC5/Irisin Inhibits the Inflammatory Response and Mediates the Aerobic Exercise-Induced Improvement of Liver Injury after Myocardial Infarction.
Wang T, Yu M, Li H, Qin S, Ren W, Ma Y, Bo W, Xi Y, Cai M, Tian Z
International journal of molecular sciences 2023 Feb 19;24(4)
International journal of molecular sciences 2023 Feb 19;24(4)
Deferoxamine prevents poststroke memory impairment in female diabetic rats: potential links to hemorrhagic transformation and ferroptosis.
Li W, Abdul Y, Chandran R, Jamil S, Ward RA, Abdelsaid M, Dong G, Fagan SC, Ergul A
American journal of physiology. Heart and circulatory physiology 2023 Feb 1;324(2):H212-H225
American journal of physiology. Heart and circulatory physiology 2023 Feb 1;324(2):H212-H225
CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-κB pathway.
Liu C, Yao K, Tian Q, Guo Y, Wang G, He P, Wang J, Wang J, Zhang Z, Li M
Redox biology 2023 Dec;68:102960
Redox biology 2023 Dec;68:102960
Neurovascular dysfunction associated with erectile dysfunction persists after long-term recovery from simulations of weightlessness and deep space irradiation.
Andrade MR, Azeez TA, Montgomery MM, Caldwell JT, Park H, Kwok AT, Borg AM, Narayanan SA, Willey JS, Delp MD, La Favor JD
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23246
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23246
The effects of astragaloside IV on gut microbiota and serum metabolism in a mice model of intracerebral hemorrhage.
Li Z, Hu E, Zheng F, Wang S, Zhang W, Luo J, Tang T, Huang Q, Wang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155086
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155086
Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization.
Shen T, Lin R, Hu C, Yu D, Ren C, Li T, Zhu M, Wan Z, Su T, Wu Y, Cai W, Yu J
Journal of neuroinflammation 2023 Dec 21;20(1):308
Journal of neuroinflammation 2023 Dec 21;20(1):308
TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation.
Wu Y, Zhan S, Chen L, Sun M, Li M, Mou X, Zhang Z, Xu L, Xu Y
Journal of translational medicine 2023 Aug 14;21(1):544
Journal of translational medicine 2023 Aug 14;21(1):544
CCL6 promotes M2 polarization and inhibits macrophage autophagy by activating PI3-kinase/Akt signalling pathway during skin wound healing.
Feng X, Ji Y, Zhang C, Jin T, Li J, Guo J
Experimental dermatology 2023 Apr;32(4):403-412
Experimental dermatology 2023 Apr;32(4):403-412
Menstrual blood-derived endometrial stem cells alleviate neuroinflammation by modulating M1/M2 polarization in cell and rat Parkinson's disease models.
Li H, Wei J, Zhang Z, Li J, Ma Y, Zhang P, Lin J
Stem cell research & therapy 2023 Apr 13;14(1):85
Stem cell research & therapy 2023 Apr 13;14(1):85
Exosomes Derived From M2 Microglia Cells Attenuates Neuronal Impairment and Mitochondrial Dysfunction in Alzheimer's Disease Through the PINK1/Parkin Pathway.
Li N, Shu J, Yang X, Wei W, Yan A
Frontiers in cellular neuroscience 2022;16:874102
Frontiers in cellular neuroscience 2022;16:874102
Exploration of the potential mechanism of Pushen capsule in the treatment of vascular dementia based on network pharmacology and experimental verification.
Liu Y, Li S, Liu D, Wei H, Wang X, Yan F
Journal of ethnopharmacology 2022 Nov 15;298:115632
Journal of ethnopharmacology 2022 Nov 15;298:115632
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Kou L, Chi X, Sun Y, Han C, Wan F, Hu J, Yin S, Wu J, Li Y, Zhou Q, Zou W, Xiong N, Huang J, Xia Y, Wang T
Journal of neuroinflammation 2022 Jun 6;19(1):133
Journal of neuroinflammation 2022 Jun 6;19(1):133
Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats.
Liu Q, Zhou S, Wang X, Gu C, Guo Q, Li X, Zhang C, Zhang N, Zhang L, Huang F
Journal of neuroinflammation 2022 Jun 20;19(1):160
Journal of neuroinflammation 2022 Jun 20;19(1):160
Neuroglobin alleviates the neurotoxicity of sevoflurane to fetal rats by inhibiting neuroinflammation and affecting microglial polarization.
Zhang Y, Gao Y, Yang F, Wu X, Tang Z, Liu H
Brain research bulletin 2022 Jun 1;183:142-152
Brain research bulletin 2022 Jun 1;183:142-152
Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway.
Li J, Liu H, Wang X, Xia Y, Huang J, Wang T, Lin Z, Xiong N
NPJ Parkinson's disease 2022 Jul 8;8(1):90
NPJ Parkinson's disease 2022 Jul 8;8(1):90
microRNA-155-3p delivered by M2 macrophages-derived exosomes enhances the progression of medulloblastoma through regulation of WDR82.
Song L, Luan B, Xu Q, Shi R, Wang X
Journal of translational medicine 2022 Jan 4;20(1):13
Journal of translational medicine 2022 Jan 4;20(1):13
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
Ni L, Xiao J, Zhang D, Shao Z, Huang C, Wang S, Wu Y, Tian N, Sun L, Wu A, Zhou Y, Wang X, Zhang X
Cell death & disease 2022 Feb 10;13(2):140
Cell death & disease 2022 Feb 10;13(2):140
ALA-PDT regulates macrophage M1 polarization via ERK/MAPK-NLRP3 pathway to promote the early inflammatory response.
Wang L, Zhang W, Cen R, Yue C, Xiao T, Deng Y, Li L, Sun K, Lei X
Lasers in surgery and medicine 2022 Dec;54(10):1309-1320
Lasers in surgery and medicine 2022 Dec;54(10):1309-1320
Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism.
Li L, Xu W, Luo Y, Lao C, Tong X, Du J, Huang B, Li D, Chen J, Ye H, Cong F, Guo X, Li J
Carbohydrate polymers 2022 Dec 1;297:120032
Carbohydrate polymers 2022 Dec 1;297:120032
Macrophage depletion blocks congenital SARM1-dependent neuropathy.
Dingwall CB, Strickland A, Yum SW, Yim AK, Zhu J, Wang PL, Yamada Y, Schmidt RE, Sasaki Y, Bloom AJ, DiAntonio A, Milbrandt J
The Journal of clinical investigation 2022 Dec 1;132(23)
The Journal of clinical investigation 2022 Dec 1;132(23)
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Ni L, Lin Z, Hu S, Shi Y, Jiang Z, Zhao J, Zhou Y, Wu Y, Tian N, Sun L, Wu A, Pan Z, Zhang X, Wang X
Biochemical pharmacology 2022 Apr;198:114935
Biochemical pharmacology 2022 Apr;198:114935
Rosuvastatin Nanomicelles Target Neuroinflammation and Improve Neurological Deficit in a Mouse Model of Intracerebral Hemorrhage.
Zi L, Zhou W, Xu J, Li J, Li N, Xu J, You C, Wang C, Tian M
International journal of nanomedicine 2021;16:2933-2947
International journal of nanomedicine 2021;16:2933-2947
Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization.
Yang R, Xie Y, Li Q, Ye Y, Shi Y, Zhao X, Wu C, Xu Y, Wang R, Zhang Y, Yang X, Han X, Liu S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Sep;141:111883
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Sep;141:111883
The Cholinergic Anti-Inflammatory Pathway Attenuates the Development of Atherosclerosis in Apoe(-/-) Mice through Modulating Macrophage Functions.
Qian Z, Yang H, Li H, Liu C, Yang L, Qu Z, Li X
Biomedicines 2021 Sep 3;9(9)
Biomedicines 2021 Sep 3;9(9)
Reactive astrocytes induced by 2-chloroethanol modulate microglia polarization through IL-1β, TNF-α, and iNOS upregulation.
Wang T, Sun Q, Yang J, Wang G, Zhao F, Chen Y, Jin Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112550
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112550
The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization.
Li W, Wang Y, Zhu L, Du S, Mao J, Wang Y, Wang S, Bo Q, Tu Y, Yi Q
Journal of cellular and molecular medicine 2021 Jul;25(14):6709-6720
Journal of cellular and molecular medicine 2021 Jul;25(14):6709-6720
Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis.
Abdul Y, Li W, Ward R, Abdelsaid M, Hafez S, Dong G, Jamil S, Wolf V, Johnson MH, Fagan SC, Ergul A
Translational stroke research 2021 Aug;12(4):615-630
Translational stroke research 2021 Aug;12(4):615-630
Injectable Gelatin Hydrogel Suppresses Inflammation and Enhances Functional Recovery in a Mouse Model of Intracerebral Hemorrhage.
Xu J, Duan Z, Qi X, Ou Y, Guo X, Zi L, Wei Y, Liu H, Ma L, Li H, You C, Tian M
Frontiers in bioengineering and biotechnology 2020;8:785
Frontiers in bioengineering and biotechnology 2020;8:785
Neuroprotective Effect of Ketone Metabolism on Inhibiting Inflammatory Response by Regulating Macrophage Polarization After Acute Cervical Spinal Cord Injury in Rats.
Lin J, Huang Z, Liu J, Huang Z, Liu Y, Liu Q, Yang Z, Li R, Wu X, Shi Z, Zhu Q, Wu X
Frontiers in neuroscience 2020;14:583611
Frontiers in neuroscience 2020;14:583611
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Lou F, Sun Y, Xu Z, Niu L, Wang Z, Deng S, Liu Z, Zhou H, Bai J, Yin Q, Cai X, Sun L, Wang H, Li Q, Wu Z, Chen X, Gu J, Shi YL, Tao W, Ginhoux F, Wang H
Immunity 2020 Jul 14;53(1):204-216.e10
Immunity 2020 Jul 14;53(1):204-216.e10
Intravenously Infusing the Secretome of Adipose-Derived Mesenchymal Stem Cells Ameliorates Neuroinflammation and Neurological Functioning After Traumatic Brain Injury.
Xu C, Diao YF, Wang J, Liang J, Xu HH, Zhao ML, Zheng B, Luan Z, Wang JJ, Yang XP, Wei MG, Duan JH, Wang KQ, Chen C, Chen F, Ming D, Zhang S, Sun HT, Li XH
Stem cells and development 2020 Feb 15;29(4):222-234
Stem cells and development 2020 Feb 15;29(4):222-234
Lipoxin A4 Regulates Lipopolysaccharide-Induced BV2 Microglial Activation and Differentiation via the Notch Signaling Pathway.
Wu J, Ding DH, Li QQ, Wang XY, Sun YY, Li LJ
Frontiers in cellular neuroscience 2019;13:19
Frontiers in cellular neuroscience 2019;13:19
Effects of exposure of adult mice to multi-walled carbon nanotubes on the liver lipid metabolism of their offspring.
Zhang HY, Chen RL, Shao Y, Wang HL, Liu ZG
Toxicology research 2018 Sep 1;7(5):809-816
Toxicology research 2018 Sep 1;7(5):809-816
Involvement of JNK signaling in IL4-induced M2 macrophage polarization.
Hao J, Hu Y, Li Y, Zhou Q, Lv X
Experimental cell research 2017 Aug 15;357(2):155-162
Experimental cell research 2017 Aug 15;357(2):155-162
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 66129-1-Ig(ARG1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The liver Arginase antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human liver Arginase. This antibody recognizes human antigen. The liver Arginase antibody has been validated for the following applications: ELISA, WB, IHC analysis.
