28728-1-AP

antibody from Proteintech Group

Targeting: ODC1 ODC

Provider product page for 28728-1-AP

Western blot

ELISA

Antibody data

Antibody Data
Antigen structure
References [21]
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Product number: 28728-1-AP - Provider product page
Provider: Proteintech Group
Product name: ODC1 antibody
Antibody type: Polyclonal
Description: ODC1 antibody (Cat. #28728-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human, mouse and has been validated for the following applications: WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ODC1 protein structure - 28728-1-AP shown in red.

Submitted references Tryptophan and polyamine metabolism dysregulation serves as an early marker of high-fat diet-induced glucose intolerance.

Gao J, Zhang L, Zhan S, Peng Z, Du J, Zhang Z, Xu L, Huang S, Wang X, Guo X
Journal of lipid research 2026 Feb;67(2):100980

A Combination of Xanthohumol and Ursolic Acid in the Diet Leads to Synergistic Inhibition of Prostate Cancer Progression.

Clark R, Saha A, Lavender Hackman G, Friedman CA, Gorgoglione R, Tiziani S, DiGiovanni J
Molecular carcinogenesis 2026 Apr;65(4):508-522

Uric acid-induced cardiomyocytic polyamines' insufficience: a potential mechanism mediates cardiomyocytic injury.

Lin C, Zheng Q, Yu H, Wu T, Chen L, Lin W, Pang J, Yang Y
Frontiers in endocrinology 2025;16:1504614

Oleanolic acid alleviates ulcerative colitis by remodeling Th17 cells via targeting HSP90β-ODC1 pathway-mediated polyamine synthesis.

Yuan Y, Tian Y, Zhao Z, Gui Y, Wang J, Zhu F, Xue G, Gao F, Liu Y, Fan H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157441

The heterogeneity of cellular metabolism in the tumour microenvironment of hepatocellular carcinoma with portal vein tumour thrombus.

Zhang XP, Zou WB, Li ZQ, Yu ZT, Yu SB, Lin ZY, Wu FF, Liu PJ, Hu MG, Liu R, Gao YZ
Cell proliferation 2025 Jan;58(1):e13738

Natural Product Quercetin-3-methyl ether Promotes Colorectal Cancer Cell Apoptosis by Downregulating Intracellular Polyamine Signaling.

Zeng J, Zhang Y, Fang Y, Lian J, Zhang H, Zhang S, Lin B, Ye Z, Li C, Qiu X, Liang Y
International journal of medical sciences 2024;21(5):904-913

Elevated expression of HIGD1A drives hepatocellular carcinoma progression by regulating polyamine metabolism through c-Myc-ODC1 nexus.

Zhang H, Li X, Liu Z, Lin Z, Huang K, Wang Y, Chen Y, Liao L, Wu L, Xie Z, Hou J, Zhang X, Liu H
Cancer & metabolism 2024 Feb 23;12(1):7

Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes.

Sims EK, Kulkarni A, Hull A, Woerner SE, Cabrera S, Mastrandrea LD, Hammoud B, Sarkar S, Nakayasu ES, Mastracci TL, Perkins SM, Ouyang F, Webb-Robertson BJ, Enriquez JR, Tersey SA, Evans-Molina C, Long SA, Blanchfield L, Gerner EW, Mirmira RG, DiMeglio LA
Cell reports. Medicine 2023 Nov 21;4(11):101261

Triptolide attenuates irritable bowel syndrome via inhibiting ODC1.

Zhu N, Zhu L, Zhang X, Huang C, Xiang W, Huang B
BMC gastroenterology 2023 Jun 12;23(1):202

Human Chorionic Gonadotropin-Stimulated Interleukin-4-Induced-1 (IL4I1) Promotes Human Decidualization via Aryl Hydrocarbon Receptor.

Luo JM, Zhang TT, He YY, Luo HN, Hong YQ, Yang ZM
International journal of molecular sciences 2023 Feb 5;24(4)

A search for acrolein scavengers among food components.

Uemura T, Uchida M, Nakamura M, Shimekake M, Sakamoto A, Terui Y, Higashi K, Ishii I, Kashiwagi K, Igarashi K
Amino acids 2023 Apr;55(4):509-518

p53 inhibits the Urea cycle and represses polyamine biosynthesis in glioma cell lines.

Zhao Y, Chen Y, Wei L, Ran J, Wang K, Zhu S, Liu Q
Metabolic brain disease 2023 Apr;38(4):1143-1153

CDC27-ODC1 Axis Promotes Metastasis, Accelerates Ferroptosis and Predicts Poor Prognosis in Neuroblastoma.

Qiu L, Zhou R, Luo Z, Wu J, Jiang H
Frontiers in oncology 2022;12:774458

SMARCE1 promotes neuroblastoma tumorigenesis through assisting MYCN-mediated transcriptional activation.

Hu X, Liu R, Hou J, Peng W, Wan S, Xu M, Li Y, Zhang G, Zhai X, Liang P, Cui H
Oncogene 2022 Sep;41(37):4295-4306

Compromised glycolysis contributes to foot process fusion of podocytes in diabetic kidney disease: Role of ornithine catabolism.

Luo Q, Liang W, Zhang Z, Zhu Z, Chen Z, Hu J, Yang K, Chi Q, Ding G
Metabolism: clinical and experimental 2022 Sep;134:155245

Urea transporter B downregulates polyamines levels in melanoma B16 cells via p53 activation.

Li J, Sun Y, Yan R, Wu X, Zou H, Meng Y
Biochimica et biophysica acta. Molecular cell research 2022 May;1869(5):119236

Targeting RNA editing of antizyme inhibitor 1: A potential oligonucleotide-based antisense therapy for cancer.

Tay DJT, Song Y, Peng B, Toh TB, Hooi L, Toh DK, Hong H, Tang SJ, Han J, Gan WL, Chan THM, Krishna MS, Patil KM, Maraswami M, Loh TP, Dan YY, Zhou L, Bonney GK, Chow PK, Chen G, Chow EK, Le MTN, Chen L
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Nov 3;29(11):3258-3273

Simultaneous Inhibition of Ornithine Decarboxylase 1 and Pyruvate Kinase M2 Exerts Synergistic Effects Against Hepatocellular Carcinoma Cells.

Zeng Z, Lan J, Lei S, Yang Y, He Z, Xue Y, Chen T
OncoTargets and therapy 2020;13:11697-11709

Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver.

Uemura T, Akasaka Y, Ikegaya H
Heliyon 2020 Sep;6(9):e05031

Polyamine regulation of porcine reproductive and respiratory syndrome virus infection depends on spermidine-spermine acetyltransferase 1.

Zhou Y, Hou Z, Fang L, Ke Q, Xiong Y, Fang P, Xiao S
Veterinary microbiology 2020 Nov;250:108839

Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex.

Kapfhamer D, McKenna J, Yoon CJ, Murray-Stewart T, Casero RA, Gambello MJ
Human molecular genetics 2020 Aug 11;29(14):2395-2407

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