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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [864]
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- Validations
- Western blot [3]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
- Other assay [56]
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- Product number
- 61-7300 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- ZO-1 Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Other
- Description
- 61-7300 has been successfully used in Western blot, Immunoprecipitation, Immunofluorescence, ELISA and Immunohistochemistry.
- Concentration
- 0.25 mg/mL
Submitted references A rodent thyroid-liver chip to capture thyroid toxicity on organ function level.
Altered Differentiation and Inflammation Profiles Contribute to Enhanced Innate Responses in Severe COPD Epithelium to Rhinovirus Infection.
Intravenous transplantation of amnion-derived mesenchymal stem cells promotes functional recovery and alleviates intestinal dysfunction after spinal cord injury.
Collagen triple helix repeat containing-1 promotes functional recovery of sweat glands by inducing adjacent microvascular network reconstruction in vivo.
Evaluation of Caco-2 and human intestinal epithelial cells as in vitro models of colonic and small intestinal integrity.
CDCP1 regulates retinal pigmented epithelial barrier integrity for the development of experimental autoimmune uveitis.
SARS-CoV-2 spike S1 subunit protein-mediated increase of beta-secretase 1 (BACE1) impairs human brain vessel cells.
Spermine protects intestinal barrier integrity through ras-related C3 botulinum toxin substrate 1/phospholipase C-γ1 signaling pathway in piglets.
Glycine represses endoplasmic reticulum stress-related apoptosis and improves intestinal barrier by activating mammalian target of rapamycin complex 1 signaling.
Addition of Chk1 inhibitor and BMP4 cooperatively promotes retinal tissue formation in self-organizing human pluripotent stem cell differentiation culture.
Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells.
Endothelial Unc5B controls blood-brain barrier integrity.
Dl-3-n-butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance.
Blocking C3d(+)/GFAP(+) A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke.
Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood-brain barrier integrity.
Immortalized human choroid plexus endothelial cells enable an advanced endothelial-epithelial two-cell type in vitro model of the choroid plexus.
DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction.
Murine in utero exposure to simulated complex urban air pollution disturbs offspring gut maturation and microbiota during intestinal suckling-to-weaning transition in a sex-dependent manner.
CU06-1004 enhances vascular integrity and improves cardiac remodeling by suppressing edema and inflammation in myocardial ischemia-reperfusion injury.
ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro.
Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium.
Engineered human blood-brain barrier microfluidic model for vascular permeability analyses.
A Novel In Vitro Membrane Permeability Methodology Using Three-dimensional Caco-2 Tubules in a Microphysiological System Which Better Mimics In Vivo Physiological Conditions.
Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity.
High-throughput formation and image-based analysis of basal-in mammary organoids in 384-well plates.
Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice.
T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model.
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu.
Blood-brain barrier dysfunction in L-ornithine induced acute pancreatitis in rats and the direct effect of L-ornithine on cultured brain endothelial cells.
Rifaximin enhances the L‑carnitine‑mediated preventive effects on skeletal muscle atrophy in cirrhotic rats by modulating the gut‑liver‑muscle axis.
Mucin O-glycan-microbiota axis orchestrates gut homeostasis in a diarrheal pig model.
Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice.
A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds.
Diosmin Alleviates Venous Injury and Muscle Damage in a Mouse Model of Iliac Vein Stenosis.
Fractalkine Is Linked to the Necrosome Pathway in Acute Pulmonary Inflammation.
The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress.
Lycium barbarum Polysaccharide Ameliorates Heat-Stress-Induced Impairment of Primary Sertoli Cells and the Blood-Testis Barrier in Rat via Androgen Receptor and Akt Phosphorylation.
The blood-brain barrier studied in vitro across species.
Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C.
Characterization of Leptin Receptor(+) Stromal Cells in Lymph Node.
Recombinant Annexin A2 Administration Improves Neurological Outcomes After Traumatic Brain Injury in Mice.
Early-Life Intervention Using Exogenous Fecal Microbiota Alleviates Gut Injury and Reduce Inflammation Caused by Weaning Stress in Piglets.
Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis.
Voiding defects in acute radiation cystitis driven by urothelial barrier defect through loss of E-cadherin, ZO-1 and Uroplakin III.
Zonula occludens 2 and Cell-Cell Contacts Are Required for Normal Nuclear Shape in Epithelia.
FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells.
Extracorporeal Shock Wave Enhances the Cisplatin Efficacy by Improving Tissue Infiltration and Cellular Uptake in an Upper Urinary Tract Cancer Animal and Human-Derived Organoid Model.
Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception.
Altered Mucus Barrier Integrity and Increased Susceptibility to Colitis in Mice upon Loss of Telocyte Bone Morphogenetic Protein Signalling.
Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.
The expression, localisation and interactome of pigeon CRY2.
Metallothionein 2 activation by pravastatin reinforces epithelial integrity and ameliorates radiation-induced enteropathy.
Single-Cell Transcriptomics Analysis of Human Small Antral Follicles.
Expression of E-Cadherin in Epithelial Cancer Cells Increases Cell Motility and Directionality through the Localization of ZO-1 during Collective Cell Migration.
Small extracellular vesicles ameliorate peripheral neuropathy and enhance chemotherapy of oxaliplatin on ovarian cancer.
Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels.
Automating Human Induced Pluripotent Stem Cell Culture and Differentiation of iPSC-Derived Retinal Pigment Epithelium for Personalized Drug Testing.
Expression pattern and prognostic impact of glycoprotein non-metastatic B (GPNMB) in triple-negative breast cancer.
Cerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals.
A defined subset of clonal retinal stem cell spheres is biased to RPE differentiation.
The Role of Processed Aloe vera Gel in Intestinal Tight Junction: An In Vivo and In Vitro Study.
Cordycepin confers long-term neuroprotection via inhibiting neutrophil infiltration and neuroinflammation after traumatic brain injury.
MAGI-1 PDZ2 Domain Blockade Averts Adenovirus Infection via Enhanced Proteolysis of the Apical Coxsackievirus and Adenovirus Receptor.
Apical CLC-2 in retinal pigment epithelium is crucial for survival of the outer retina.
Clarithromycin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage via Suppressing Periostin-Related Pathways in Mice.
Planar cell polarity induces local microtubule bundling for coordinated ciliary beating.
The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia.
NLRP3 inhibition attenuates early brain injury and delayed cerebral vasospasm after subarachnoid hemorrhage.
Alveolar epithelial glycocalyx shedding aggravates the epithelial barrier and disrupts epithelial tight junctions in acute respiratory distress syndrome.
ATPIF1 maintains normal mitochondrial structure which is impaired by CCM3 deficiency in endothelial cells.
Structural disruption of the blood-brain barrier in repetitive primary blast injury.
Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial-mesenchymal transition by targeting HOXC6.
Dynamic conversion of cell sorting patterns in aggregates of embryonic stem cells with differential adhesive affinity.
Quercetin Alleviates Oxidative Damage by Activating Nuclear Factor Erythroid 2-Related Factor 2 Signaling in Porcine Enterocytes.
Citrus limon Peel Powder Reduces Intestinal Barrier Defects and Inflammation in a Colitic Murine Experimental Model.
Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE.
Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing.
ILC1 drive intestinal epithelial and matrix remodelling.
The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα.
Epithelial-Specific TLR4 Knockout Challenges Current Evidence of TLR4 Homeostatic Control of Gut Permeability.
KRT8 (keratin 8) attenuates necrotic cell death by facilitating mitochondrial fission-mediated mitophagy through interaction with PLEC (plectin).
Silencing of lncRNA XIST impairs angiogenesis and exacerbates cerebral vascular injury after ischemic stroke.
Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrity.
Nano-scale architecture of blood-brain barrier tight-junctions.
NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood-brain barrier integrity in murine stroke.
The laminin-binding integrins regulate nuclear factor κB-dependent epithelial cell polarity and inflammation.
Unravelling the Role of PAX2 Mutation in Human Focal Segmental Glomerulosclerosis.
Long noncoding RNA ERLR mediates epithelial-mesenchymal transition of retinal pigment epithelial cells and promotes experimental proliferative vitreoretinopathy.
Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function.
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.
Permissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease.
Genomic diversity contributes to the neuroinvasiveness of the Yellow fever French neurotropic vaccine.
Transport of Dietary Anti-Inflammatory Peptide, γ-Glutamyl Valine (γ-EV), across the Intestinal Caco-2 Monolayer.
Transverse aortic constriction induces gut barrier alterations, microbiota remodeling and systemic inflammation.
Molecular mechanism mediating enteric bacterial translocation after severe burn: the role of cystic fibrosis transmembrane conductance regulator.
Expression of R345W-Fibulin-3 Induces Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells.
Optimisation of a Novel Bio-Substrate as a Treatment for Atrophic Age-Related Macular Degeneration.
Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development.
Cisplatin-Induced Stria Vascularis Damage Is Associated with Inflammation and Fibrosis.
Metformin Protects ARPE-19 Cells from Glyoxal-Induced Oxidative Stress.
Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability.
Testisin/Prss21 deficiency causes increased vascular permeability and a hemorrhagic phenotype during luteal angiogenesis.
In vivo and ex vivo assessment of bladder hyper-permeability and using molecular targeted magnetic resonance imaging to detect claudin-2 in a mouse model for interstitial cystitis.
Isolation of Mouse Cerebral Microvasculature for Molecular and Single-Cell Analysis.
DL-3n-Butylphthalide Improves Blood-Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion.
Specific Frequency Electroacupuncture Stimulation Transiently Enhances the Permeability of the Blood-Brain Barrier and Induces Tight Junction Changes.
Reduced Post-ischemic Brain Injury in Transient Receptor Potential Vanilloid 4 Knockout Mice.
Connexin36 localization along axon initial segments in the mammalian CNS.
Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke.
Endothelial Cell Orientation and Polarity Are Controlled by Shear Stress and VEGF Through Distinct Signaling Pathways.
Astragalus mongholicus Bunge and Panax Notoginseng Formula (A&P) Combined With Bifidobacterium Contribute a Renoprotective Effect in Chronic Kidney Disease Through Inhibiting Macrophage Inflammatory Response in Kidney and Intestine.
Stachyose Improves the Effects of Berberine on Glucose Metabolism by Regulating Intestinal Microbiota and Short-Chain Fatty Acids in Spontaneous Type 2 Diabetic KKAy Mice.
Retinal Distribution and Extracellular Activity of Granzyme B: A Serine Protease That Degrades Retinal Pigment Epithelial Tight Junctions and Extracellular Matrix Proteins.
A Method for Developing Novel 3D Cornea-on-a-Chip Using Primary Murine Corneal Epithelial and Endothelial Cells.
Impaired Airway Epithelial Barrier Integrity in Response to Stenotrophomonas maltophilia Proteases, Novel Insights Using Cystic Fibrosis Bronchial Epithelial Cell Secretomics.
Resveratrol Modulates the Gut Microbiota and Inflammation to Protect Against Diabetic Nephropathy in Mice.
AhR activation defends gut barrier integrity against damage occurring in obesity.
Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction.
Novel developmental bases for the evolution of hypobranchial muscles in vertebrates.
The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis.
Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2.
Tanycyte ablation in the arcuate nucleus and median eminence increases obesity susceptibility by increasing body fat content in male mice.
Experimental design of a culture approach for corneal endothelial cells of New Zealand white rabbit.
Effect of ultra‑wide‑band electromagnetic pulses on blood‑brain barrier permeability in rats.
RAB6 GTPase regulates mammary secretory function by controlling the activation of STAT5.
Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing.
Increased intestinal permeability and gut dysbiosis in the R6/2 mouse model of Huntington's disease.
Behavioral and neurophysiological taste responses to sweet and salt are diminished in a model of subclinical intestinal inflammation.
Non-Human Primate Blood-Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model.
Heterozygous Loss of Yap1 in Mice Causes Progressive Cataracts.
MiR-22-3p inhibits fibrotic cataract through inactivation of HDAC6 and increase of α-tubulin acetylation.
Hypertonic saline improves brain edema resulting from traumatic brain injury by suppressing the NF-κB/IL-1β signaling pathway and AQP4.
Quantitative analysis and virulence phenotypes of atypical enteropathogenic Escherichia coli (EPEC) acquired from diarrheal stool samples from a Midwest US hospital.
Correlations between α-Linolenic Acid-Improved Multitissue Homeostasis and Gut Microbiota in Mice Fed a High-Fat Diet.
Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer's disease.
Modulation of NLRP3 Inflammasome Attenuated Inflammatory Response Associated to Diarrhea-Predominant Irritable Bowel Syndrome.
Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells.
Cell-Type-Specific Complement Profiling in the ABCA4(-/-) Mouse Model of Stargardt Disease.
Exosome/microvesicle content is altered in leucine-rich repeat kinase 2 mutant induced pluripotent stem cell-derived neural cells.
A Semiautomated, Phenotypic, In Vitro Scratch Assay for Assessing Retinal Pigment Epithelial Cell Wound Healing.
Luteolin prevents irinotecan-induced intestinal mucositis in mice through antioxidant and anti-inflammatory properties.
Preliminary Assessment of the Mucosal Toxicity of Tea Tree (Melaleuca alternifolia) and Rosemary (Rosmarinus officinalis) Essential Oils on Novel Porcine Uterus Models.
Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies.
Transcriptomic profiles reveal differences in zinc metabolism, inflammation, and tight junction proteins in duodenum from cholesterol gallstone subjects.
Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease.
Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke.
Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision.
YAP Mediates Hair Cell Regeneration in Balance Organs of Chickens, But LATS Kinases Suppress Its Activity in Mice.
Transporter-Mediated Mitochondrial GSH Depletion Leading to Mitochondrial Dysfunction and Rescue with αB Crystallin Peptide in RPE Cells.
TGF-β1 relieves epithelial-mesenchymal transition reduction in hypospadias induced by DEHP in rats.
Engineering the mode of morphogenetic signal presentation to promote branching from salivary gland spheroids in 3D hydrogels.
Enhancement of aberrantly modified integrin‑mediated cell motility in multicellular tumor spheroids.
Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease.
Brain tight junction protein expression in sepsis in an autopsy series.
RBFOX1 Regulates the Permeability of the Blood-Tumor Barrier via the LINC00673/MAFF Pathway.
Development of a human in vitro blood-brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance.
Challenging human somatic testicular cell reassembly by protein kinase inhibition -setting up a functional in vitro test system.
Bile Acid Sequestrant, Sevelamer Ameliorates Hepatic Fibrosis with Reduced Overload of Endogenous Lipopolysaccharide in Experimental Nonalcoholic Steatohepatitis.
Transcriptome-Wide Analysis of CXCR5 Deficient Retinal Pigment Epithelial (RPE) Cells Reveals Molecular Signatures of RPE Homeostasis.
Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation.
Significant Changes in Trans-Epithelial Barrier Proteins of Adenoid Tissue with Atopic Status in Children.
Snail induces epithelial cell extrusion by regulating RhoA contractile signalling and cell-matrix adhesion.
In-Depth Study of Transmembrane Mucins in Association with Intestinal Barrier Dysfunction During the Course of T Cell Transfer and DSS-Induced Colitis.
Placental gene editing via trophectoderm-specific Tat-Cre/loxP recombination.
Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis.
MCH Neurons Regulate Permeability of the Median Eminence Barrier.
Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation.
Intestinal Enteroid Culture for Human Astroviruses.
Regulatory Effect of Lactobacillus brevis Bmb6 on Gut Barrier Functions in Experimental Colitis.
IL-1β strengthens the physical barrier in gingival epithelial cells.
Topical Delivery of Curcumin by Choline-Calix[4]arene-Based Nanohydrogel Improves Its Therapeutic Effect on a Psoriasis Mouse Model.
Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation.
Mechano-modulatory synthetic niches for liver organoid derivation.
Differential expression of cell-cell junction proteins in the testis, epididymis, and ductus deferens of domestic turkeys (Meleagris gallopavo) with white and yellow semen.
Expression of Neurotrophic Factors, Tight Junction Proteins, and Cytokines According to the Irritable Bowel Syndrome Subtype and Sex.
The tight junction protein TJP1 regulates the feeding-modulated hepatic circadian clock.
Epithelial-specific isoforms of protein 4.1R promote adherens junction assembly in maturing epithelia.
Jedi-1 deficiency increases sensory neuron excitability through a non-cell autonomous mechanism.
The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction.
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.
An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes.
Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers.
Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation.
Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis.
Vascular Tumor Recapitulated in Endothelial Cells from hiPSCs Engineered to Express the SERPINE1-FOSB Translocation.
Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NFκB activation.
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion.
Systemic Inflammation by Collagen-Induced Arthritis Affects the Progression of Age-Related Macular Degeneration Differently in Two Mouse Models of the Disease.
Mechanisms of stretch-mediated skin expansion at single-cell resolution.
Lnc00462717 regulates the permeability of the blood-brain tumor barrier through interaction with PTBP1 to inhibit the miR-186-5p/Occludin signaling pathway.
Sigma-1 receptor activation-induced glycolytic ATP production and endothelial barrier enhancement.
HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis.
Human iPSC Modeling Reveals Mutation-Specific Responses to Gene Therapy in a Genotypically Diverse Dominant Maculopathy.
Neutrophil Extracellular Traps Impair Intestinal Barrier Function during Experimental Colitis.
Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier.
The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples.
The spleen mediates chronic sleep restriction-mediated enhancement of LPS-induced neuroinflammation, cognitive deficits, and anxiety-like behavior.
Maltodextrin-induced intestinal injury in a neonatal mouse model.
Axl Deficiency Promotes the Neuroinvasion of Japanese Encephalitis Virus by Enhancing IL-1α Production from Pyroptotic Macrophages.
Transition of podosomes into zipper-like structures in macrophage-derived multinucleated giant cells.
Eugenol attenuates inflammatory response and enhances barrier function during lipopolysaccharide-induced inflammation in the porcine intestinal epithelial cells.
Pioglitazone Attenuates Experimental Colitis-Associated Hyperalgesia through Improving the Intestinal Barrier Dysfunction.
Role of monocarboxylate transporters in regulating metabolic homeostasis in the outer retina: Insight gained from cell-specific Bsg deletion.
Prevention of excessive exercise-induced adverse effects in rats with Bacillus subtilis BSB3.
Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity.
KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke.
Expression of Tight Junction Proteins According to Functional Dyspepsia Subtype and Sex.
Use of EpiAlveolar Lung Model to Predict Fibrotic Potential of Multiwalled Carbon Nanotubes.
Isolation and initial propagation of guinea pig adenovirus (GPAdV) in Cavia porcellus cell lines.
Occludin knockdown is not sufficient to induce transepithelial macromolecule passage.
Arresting proliferation improves the cell identity of corneal endothelial cells in the New Zealand rabbit.
Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish.
Transfusion of Resting Platelets Reduces Brain Hemorrhage After Intracerebral Hemorrhage and tPA-Induced Hemorrhage After Cerebral Ischemia.
Influence of a Hyperglycemic Microenvironment on a Diabetic Versus Healthy Rat Vascular Endothelium Reveals Distinguishable Mechanistic and Phenotypic Responses.
Sexual Dimorphism in Immune Development and in Response to Nutritional Intervention in Neonatal Piglets.
Hypertonic saline downregulates endothelial cell-derived VEGF expression and reduces blood-brain barrier permeability induced by cerebral ischaemia via the VEGFR2/eNOS pathway.
Syncytiotrophoblast of Placentae from Women with Zika Virus Infection Has Altered Tight Junction Protein Expression and Increased Paracellular Permeability.
Attenuated Amiloride-Sensitive Current and Augmented Calcium-Activated Chloride Current in Marsh Rice Rat (Oryzomys palustris) Airways.
Pepsin Triggers Neutrophil Migration Across Acid Damaged Lung Epithelium.
Expression of a CARD Slows the Retinal Degeneration of a Geographic Atrophy Mouse Model.
Claudin-12 is not required for blood-brain barrier tight junction function.
CRISPR-Cas9-mediated therapeutic editing of Rpe65 ameliorates the disease phenotypes in a mouse model of Leber congenital amaurosis.
The microstructure of laminin-111 compensates for dystroglycan loss in mammary epithelial cells in downstream expression of milk proteins.
Tunicamycin-induced photoreceptor atrophy precedes degeneration of retinal capillaries with minimal effects on retinal ganglion and pigment epithelium cells.
Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke.
Effects of Claudin-1 on the Action of Clostridium perfringens Enterotoxin in Caco-2 Cells.
Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity.
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures.
Changes in brain kynurenine levels via gut microbiota and gut-barrier disruption induced by chronic ethanol exposure in mice.
Characterization of the polarized endothelial secretome.
In vitro and in vivo effects of a mycotoxin, deoxynivalenol, and a trace metal, cadmium, alone or in a mixture on the intestinal barrier.
A Simulated Microgravity Environment Causes a Sustained Defect in Epithelial Barrier Function.
High-fat diet-mediated dysbiosis exacerbates NSAID-induced small intestinal damage through the induction of interleukin-17A.
A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes.
Tracking adiponectin biodistribution via fluorescence molecular tomography indicates increased vascular permeability after streptozotocin-induced diabetes.
HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice.
Targeting the HIV-infected brain to improve ischemic stroke outcome.
Vascular regeneration in adult mouse cochlea stimulated by VEGF-A(165) and driven by NG2-derived cells ex vivo.
Polarized AAVR expression determines infectivity by AAV gene therapy vectors.
Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration.
A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor.
gH625-liposomes as tool for pituitary adenylate cyclase-activating polypeptide brain delivery.
Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture.
Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: An in vitro study.
Effect of Manitoba-Grown Red-Osier Dogwood Extracts on Recovering Caco-2 Cells from H(2)O(2)-Induced Oxidative Damage.
The Y227N mutation affects bestrophin-1 protein stability and impairs sperm function in a mouse model of Best vitelliform macular dystrophy.
Pretreatment with probiotic Enterococcus faecium NCIMB 11181 ameliorates necrotic enteritis-induced intestinal barrier injury in broiler chickens.
mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model.
Derivation of Mouse Haploid Trophoblast Stem Cells.
Human Brain Endothelial CXCR2 is Inflammation-Inducible and Mediates CXCL5- and CXCL8-Triggered Paraendothelial Barrier Breakdown.
Ferulic acid protects against heat stress-induced intestinal epithelial barrier dysfunction in IEC-6 cells via the PI3K/Akt-mediated Nrf2/HO-1 signaling pathway.
Protease-activated receptor-1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy.
p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects.
Decreased ω-6:ω-3 PUFA ratio attenuates ethanol-induced alterations in intestinal homeostasis, microbiota, and liver injury.
Massive centriole production can occur in the absence of deuterosomes in multiciliated cells.
Sperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia.
The Use of High-Throughput Transcriptomics to Identify Pathways with Therapeutic Significance in Podocytes.
Phenotypic characteristics of human bone marrow-derived endothelial progenitor cells in vitro support cell effectiveness for repair of the blood-spinal cord barrier in ALS.
E-cadherin is downregulated in benign prostatic hyperplasia and required for tight junction formation and permeability barrier in the prostatic epithelial cell monolayer.
ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion.
Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform.
CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells.
Establishment of Primary Transgenic Human Airway Epithelial Cell Cultures to Study Respiratory Virus-Host Interactions.
Microtubules are required for the maintenance of planar cell polarity in monociliated floorplate cells.
Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria.
Glibenclamide ameliorates the disrupted blood-brain barrier in experimental intracerebral hemorrhage by inhibiting the activation of NLRP3 inflammasome.
Serine Threonine Kinase 17A Maintains the Epithelial State in Colorectal Cancer Cells.
Regulation of cilia abundance in multiciliated cells.
Determining the Replication Kinetics and Cellular Tropism of Influenza D Virus on Primary Well-Differentiated Human Airway Epithelial Cells.
The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt-Sox9 signaling.
Afadin Downregulation by Helicobacter pylori Induces Epithelial to Mesenchymal Transition in Gastric Cells.
Dynamic Formation of Microvillus Inclusions During Enterocyte Differentiation in Munc18-2-Deficient Intestinal Organoids.
Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs.
Brain Barrier Disruption and Region-Specific Neuronal Degeneration during Necrotizing Enterocolitis in Preterm Pigs.
Cyp1b1 expression impacts the angiogenic and inflammatory properties of liver sinusoidal endothelial cells.
Protective Effects of L-902,688, a Prostanoid EP4 Receptor Agonist, against Acute Blood-Brain Barrier Damage in Experimental Ischemic Stroke.
TLR2 Ligand Pam3CSK4 Regulates MMP-2/9 Expression by MAPK/NF-κB Signaling Pathways in Primary Brain Microvascular Endothelial Cells.
Retinoic acid signaling is essential for maintenance of the blood-retinal barrier.
Calprotectin protects against experimental colonic inflammation in mice.
Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles.
Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate.
Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation.
Human Defensin-5 Blocks Ethanol and Colitis-Induced Dysbiosis, Tight Junction Disruption and Inflammation in Mouse Intestine.
Effects of 17β-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse Model.
Stromal fibroblast activation protein alpha promotes gastric cancer progression via epithelial-mesenchymal transition through Wnt/ β-catenin pathway.
Nephron-specific knockin of the PIKfyve-binding-deficient Vac14(L156R) mutant results in albuminuria and mesangial expansion.
Dynein 1 supports spermatid transport and spermiation during spermatogenesis in the rat testis.
Postpartum increases in cerebral edema and inflammation in response to placental ischemia during pregnancy.
CLAMP/Spef1 regulates planar cell polarity signaling and asymmetric microtubule accumulation in the Xenopus ciliated epithelia.
Regulation of blood-testis barrier assembly in vivo by germ cells.
Neural progenitor fate decision defects, cortical hypoplasia and behavioral impairment in Celsr1-deficient mice.
Requirement of the F-actin-binding activity of l-afadin for enhancing the formation of adherens and tight junctions.
Sleep deprivation disrupts the lacrimal system and induces dry eye disease.
Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.
MicroRNA-Mediated Therapy Modulating Blood-Brain Barrier Disruption Improves Vascular Cognitive Impairment.
Delivery of CR2-fH Using AAV Vector Therapy as Treatment Strategy in the Mouse Model of Choroidal Neovascularization.
The atypical mitogen-activated protein kinase ERK3 is essential for establishment of epithelial architecture.
Immunohistochemistry in Investigative and Toxicologic Pathology.
HDAC inhibitors, trichostatin A and valproic acid, increase E‑cadherin and vimentin expression but inhibit migration and invasion of cholangiocarcinoma cells.
0.005% Preservative-Free Latanoprost Induces Dry Eye-Like Ocular Surface Damage via Promotion of Inflammation in Mice.
Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases.
Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport.
Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway.
FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction.
Dacomitinib-induced diarrhea: Targeting chloride secretion with crofelemer.
Enteropathogenic E. coli effectors EspF and Map independently disrupt tight junctions through distinct mechanisms involving transcriptional and post-transcriptional regulation.
Human Primary Cell-Based Organotypic Microtissues for Modeling Small Intestinal Drug Absorption.
Light action spectrum on oxidative stress and mitochondrial damage in A2E-loaded retinal pigment epithelium cells.
Reassembly of adult human testicular cells: can testis cord-like structures be created in vitro?
Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation.
PyMT-1099, a versatile murine cell model for EMT in breast cancer.
Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules.
β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability.
Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis.
Bis-Retinoid A2E Induces an Increase of Basic Fibroblast Growth Factor via Inhibition of Extracellular Signal-Regulated Kinases 1/2 Pathway in Retinal Pigment Epithelium Cells and Facilitates Phagocytosis.
Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells.
Protective barrier properties of Rhinosectan(®) spray (containing xyloglucan) on an organotypic 3D airway tissue model (MucilAir): results of an in vitro study.
Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration.
Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite.
Netrin-1 Ameliorates Blood-Brain Barrier Impairment Secondary to Ischemic Stroke via the Activation of PI3K Pathway.
Puerarin transport across rat nasal epithelial cells and the influence of compatibility with peoniflorin and menthol.
Human salivary peptide histatin-1 stimulates epithelial and endothelial cell adhesion and barrier function.
Epithelial expression and function of trypsin-3 in irritable bowel syndrome.
Blood-spinal cord barrier breakdown and pericyte deficiency in peripheral neuropathy.
Cell-specific diversity in the expression and organization of cytoplasmic plaque proteins of apical junctions.
Stem Cell Derived Retinal Pigment Epithelium: The Role of Pigmentation as Maturation Marker and Gene Expression Profile Comparison with Human Endogenous Retinal Pigment Epithelium.
Genome editing reveals a role for OCT4 in human embryogenesis.
Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.
miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis.
Olaquindox disrupts tight junction integrity and cytoskeleton architecture in mouse Sertoli cells.
Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro.
FK506 suppresses hypoxia‑induced inflammation and protects tight junction function via the CaN‑NFATc1 signaling pathway in retinal microvascular epithelial cells.
Context-dependent compensation among phosphatidylserine-recognition receptors.
Cell-cell adhesion accounts for the different orientation of columnar and hepatocytic cell divisions.
Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations.
FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development.
Lamin Cleavage: A Reliable Marker for Studying Staurosporine-Induced Apoptosis in Corneal Tissue.
Direct and efficient transfection of mouse neural stem cells and mature neurons by in vivo mRNA electroporation.
Targeting the tight junction protein, zonula occludens-1, with the connexin43 mimetic peptide, αCT1, reduces VEGF-dependent RPE pathophysiology.
Inflammatory demyelination induces ependymal modifications concomitant to activation of adult (SVZ) stem cell proliferation.
VIP Family Members Prevent Outer Blood Retinal Barrier Damage in a Model of Diabetic Macular Edema.
Aging-dependent expression of synapse-related proteins in the mouse brain.
Variants of β-casofensin, a bioactive milk peptide, differently modulate the intestinal barrier: In vivo and ex vivo studies in rats.
Plastic roles of pericytes in the blood-retinal barrier.
Establishment, maintenance and functional integrity of the blood-testis barrier in organotypic cultures of fresh and frozen/thawed prepubertal mouse testes.
Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway.
Culture media-based selection of endothelial cells, pericytes, and perivascular-resident macrophage-like melanocytes from the young mouse vestibular system.
Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier.
Knockdown of long non-coding RNA XIST increases blood-tumor barrier permeability and inhibits glioma angiogenesis by targeting miR-137.
Protective Effect of Met12, a Small Peptide Inhibitor of Fas, on the Retinal Pigment Epithelium and Photoreceptor After Sodium Iodate Injury.
Ghrelin ameliorates blood-brain barrier disruption during systemic hypoxia.
Par3 in chick lens placode development.
Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration.
Pten facilitates epiblast epithelial polarization and proamniotic lumen formation in early mouse embryos.
TRPV4 Regulates Tight Junctions and Affects Differentiation in a Cell Culture Model of the Corneal Epithelium.
Effects of MMP12 on cell motility and inflammation during corneal epithelial repair.
Leptospira interrogans causes quantitative and morphological disturbances in adherens junctions and other biological groups of proteins in human endothelial cells.
Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links.
Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment.
Defective CFTR leads to aberrant β-catenin activation and kidney fibrosis.
Mitosis can drive cell cannibalism through entosis.
Urban fine particulate matter exposure causes male reproductive injury through destroying blood-testis barrier (BTB) integrity.
Proliferation-independent regulation of organ size by Fgf/Notch signaling.
ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens.
Deep nuclear invaginations are linked to cytoskeletal filaments - integrated bioimaging of epithelial cells in 3D culture.
Regulation of the blood-testis barrier by a local axis in the testis: role of laminin α2 in the basement membrane.
Low-Dose Lipopolysaccharide Causes Biliary Injury by Blood Biliary Barrier Impairment in a Rat Hepatic Ischemia/Reperfusion Model.
Autophagy and KRT8/keratin 8 protect degeneration of retinal pigment epithelium under oxidative stress.
Development of an in vitro co-culture model to mimic the human intestine in healthy and diseased state.
Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia.
Matrix metalloproteinase-2 and -9 contribute to functional integrity and noise‑induced damage to the blood-labyrinth-barrier.
Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes.
Descemet's Membrane Supports Corneal Endothelial Cell Regeneration in Rabbits.
Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury.
A responsive human triple-culture model of the air-blood barrier: incorporation of different macrophage phenotypes.
ERK signalling modulates epigenome to drive epithelial to mesenchymal transition.
Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1.
Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease.
Glioma-associated oncogene homolog 1 promotes epithelial-mesenchymal transition in human renal tubular epithelial cell.
Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier.
Differentiation/Purification Protocol for Retinal Pigment Epithelium from Mouse Induced Pluripotent Stem Cells as a Research Tool.
Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition.
Selection of a Relevant In Vitro Blood-Brain Barrier Model to Investigate Pro-Metastatic Features of Human Breast Cancer Cell Lines.
The role of the intestinal microvasculature in inflammatory bowel disease: studies with a modified Caco-2 model including endothelial cells resembling the intestinal barrier in vitro.
A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening.
VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation.
Loss of ZFP36 expression in colorectal cancer correlates to wnt/ ß-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of ZEB1, SOX9 and MACC1.
Yes-associated protein impacts adherens junction assembly through regulating actin cytoskeleton organization.
Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability.
Dual effects of a high-protein diet on DSS-treated mice during colitis resolution phase.
The impact of autophagy on the development of senescence in primary tubular epithelial cells.
The role of pericytic laminin in blood brain barrier integrity maintenance.
Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II.
Loss of Neurokinin-1 Receptor Alters Ocular Surface Homeostasis and Promotes an Early Development of Herpes Stromal Keratitis.
Functional roles of MMP14 and MMP15 in early postnatal mammary gland development.
Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial-to-mesenchymal transition (EMT) in bladder cancer.
Interleukin 1alpha-induced disruption of the Sertoli cell cytoskeleton affects gap junctional communication.
Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway.
Planar Cell Polarity (PCP) Protein Vangl2 Regulates Ectoplasmic Specialization Dynamics via Its Effects on Actin Microfilaments in the Testes of Male Rats.
Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.
The blood-tendon barrier: identification and characterisation of a novel tissue barrier in tendon blood vessels.
The blood-tendon barrier: identification and characterisation of a novel tissue barrier in tendon blood vessels.
PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins.
MicroRNA-107 prevents amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1.
Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier.
Retinal Pigment Epithelium Atrophy 1 (rpea1): A New Mouse Model With Retinal Detachment Caused by a Disruption of Protein Kinase C, θ.
Increased expression of dermatopontin and its implications for testicular dysfunction in mice.
PCP Signaling between Migrating Neurons and their Planar-Polarized Neuroepithelial Environment Controls Filopodial Dynamics and Directional Migration.
Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation.
Specific deletion of AMP-activated protein kinase (α1AMPK) in mouse Sertoli cells modifies germ cell quality.
Acetylated bacterial cellulose coated with urinary bladder matrix as a substrate for retinal pigment epithelium.
293 cells express both epithelial as well as mesenchymal cell adhesion molecules.
MicroRNA-150 regulates blood-brain barrier permeability via Tie-2 after permanent middle cerebral artery occlusion in rats.
Maternal Obesity in the Mouse Compromises the Blood-Brain Barrier in the Arcuate Nucleus of Offspring.
Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells.
Alix-mediated assembly of the actomyosin-tight junction polarity complex preserves epithelial polarity and epithelial barrier.
Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland.
Adropin reduces paracellular permeability of rat brain endothelial cells exposed to ischemia-like conditions.
A novel in vitro platform for the study of SN38-induced mucosal damage and the development of Toll-like receptor 4-targeted therapeutic options.
Reduced insulin secretion function is associated with pancreatic islet redistribution of cell adhesion molecules (CAMS) in diabetic mice after prolonged high-fat diet.
Rescue of perfluorooctanesulfonate (PFOS)-mediated Sertoli cell injury by overexpression of gap junction protein connexin 43.
C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms.
Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier.
Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice.
The levels of epithelial anchor proteins β-catenin and zona occludens-1 are altered by E7 of human papillomaviruses 5 and 8.
A comparative study of epidermal tight junction proteins in a dog model of atopic dermatitis.
Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection.
Gonadotropin suppression in men leads to a reduction in claudin-11 at the Sertoli cell tight junction.
Connexin 43 reboots meiosis and reseals blood-testis barrier following toxicant-mediated aspermatogenesis and barrier disruption.
Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer.
Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo.
Hematopoietic Stem Cells Transplantation Can Normalize Thyroid Function in a Cystinosis Mouse Model.
Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening.
Generation and functional characterization of epithelial cells with stable expression of SLC26A9 Cl- channels.
A Method for the Isolation and Culture of Adult Rat Retinal Pigment Epithelial (RPE) Cells to Study Retinal Diseases.
A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions.
Methodologies for analysis of patterning in the mouse RPE sheet.
A Triple Culture Model of the Blood-Brain Barrier Using Porcine Brain Endothelial cells, Astrocytes and Pericytes.
Lipopolysaccharide-induced middle ear inflammation disrupts the cochlear intra-strial fluid-blood barrier through down-regulation of tight junction proteins.
Actin-bundling protein plastin 3 is a regulator of ectoplasmic specialization dynamics during spermatogenesis in the rat testis.
Development of a Bronchial Wall Model: Triple Culture on a Decellularized Porcine Trachea.
ETB receptor-mediated MMP-9 activation induces vasogenic edema via ZO-1 protein degradation following status epilepticus.
The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.
Characterization of the equine blood-testis barrier during tubular development in normal and cryptorchid stallions.
Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin.
Liver-Tumor Hybrid Organoids for Modeling Tumor Growth and Drug Response In Vitro.
HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model.
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.
Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization.
A Rotating Bioreactor for Scalable Culture and Differentiation of Respiratory Epithelium.
Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis.
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.
Injury to the blood-testis barrier after low-dose-rate chronic radiation exposure in mice.
Slc15a1 is involved in the transport of synthetic F5-peptide into the seminiferous epithelium in adult rat testes.
Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer's disease.
Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways.
Short communication: Glucagon-like peptide-2 and coccidiosis alter tight junction gene expression in the gastrointestinal tract of dairy calves.
Brain barrier properties and cerebral blood flow in neonatal mice exposed to cerebral hypoxia-ischemia.
Alterations of intercellular junctions in peritoneal mesothelial cells from patients undergoing dialysis: effect of retinoic Acid.
Musashi-1 maintains blood-testis barrier structure during spermatogenesis and regulates stress granule formation upon heat stress.
MTH1 expression is required for effective transformation by oncogenic HRAS.
Neural crest specification by inhibition of the ROCK/Myosin II pathway.
Biophysical characterization of interactions between the C-termini of peripheral nerve claudins and the PDZ₁ domain of zonula occludens.
Vessel maturation schedule determines vulnerability to neuronal injuries of prematurity.
Design and validation of a clinical-scale bioreactor for long-term isolated lung culture.
TRPV4 regulates the integrity of the blood-cerebrospinal fluid barrier and modulates transepithelial protein transport.
Bacterial induction of Snail1 contributes to blood-brain barrier disruption.
Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.
Dexamethasone potentiates in vitro blood-brain barrier recovery after primary blast injury by glucocorticoid receptor-mediated upregulation of ZO-1 tight junction protein.
TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways.
Barrier Function of the Repaired Skin Is Disrupted Following Arrest of Dicer in Keratinocytes.
MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell-cell junctions in epithelial cells.
Roundabout 4 regulates blood-tumor barrier permeability through the modulation of ZO-1, Occludin, and Claudin-5 expression.
EGF regulates claudin-2 and -4 expression through Src and STAT3 in MDCK cells.
Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.
Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery.
An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation.
Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling.
EB1 regulates tubulin and actin cytoskeletal networks at the sertoli cell blood-testis barrier in male rats: an in vitro study.
Generation of highly enriched populations of optic vesicle-like retinal cells from human pluripotent stem cells.
Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin.
Effects of low-level laser irradiation on proliferation and functional protein expression in human RPE cells.
Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke.
Identification of CCL2, RARRES2 and EFNB2 as host cell factors that influence the multistep replication of respiratory syncytial virus.
Abnormalities in Expression of Structural, Barrier and Differentiation Related Proteins, and Chondroitin Sulfate in Feline and Human Interstitial Cystitis.
Transfection of brain capillary endothelial cells in primary culture with defined blood-brain barrier properties.
Expression of tight junction proteins and transporters for xenobiotic metabolism at the blood-CSF barrier during development in the nonhuman primate (P. hamadryas).
The long noncoding RNA TUG1 regulates blood-tumor barrier permeability by targeting miR-144.
JNK-dependent gene regulatory circuitry governs mesenchymal fate.
Paclitaxel-induced lung injury and its amelioration by parecoxib sodium.
Increasing fat content from 20 to 45 wt% in a complex diet induces lower endotoxemia in parallel with an increased number of intestinal goblet cells in mice.
Control of cell-cell forces and collective cell dynamics by the intercellular adhesome.
Increased gut permeability and bacterial translocation after chronic chlorpyrifos exposure in rats.
Berberine protects against neuronal damage via suppression of glia-mediated inflammation in traumatic brain injury.
Loss of EP2 receptor subtype in colonic cells compromise epithelial barrier integrity by altering claudin-4.
Autonomous stimulation of cancer cell plasticity by the human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells.
The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress.
Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina.
Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion.
A neurovascular blood-brain barrier in vitro model.
In-depth characterisation of Retinal Pigment Epithelium (RPE) cells derived from human induced pluripotent stem cells (hiPSC).
Bleeding propensity of cavernous malformations: impact of tight junction alterations on the occurrence of overt hematoma.
Myosin Vb mediated plasma membrane homeostasis regulates peridermal cell size and maintains tissue homeostasis in the zebrafish epidermis.
FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis.
The angiopoietin1-Akt pathway regulates barrier function of the cultured spinal cord microvascular endothelial cells through Eps8.
Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst.
A PKA-ezrin-Cx43 signaling complex controls gap junction communication and thereby trophoblast cell fusion.
The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells.
Long-term ketamine abuse induces cystitis in rats by impairing the bladder epithelial barrier.
The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions.
Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice.
The RAB5-GEF function of RIN1 regulates multiple steps during Listeria monocytogenes infection.
The gut microbiota influences blood-brain barrier permeability in mice.
rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9.
Fascin 1 is an actin filament-bundling protein that regulates ectoplasmic specialization dynamics in the rat testis.
Electrical synaptic transmission in developing zebrafish: properties and molecular composition of gap junctions at a central auditory synapse.
Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition.
Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer.
Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.
A plasminogen activator inhibitor type 1 mutant retards diabetic nephropathy in db/db mice by protecting podocytes.
LIM-homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF-B signaling.
Lipopolysaccharide precipitates hepatic encephalopathy and increases blood-brain barrier permeability in mice with acute liver failure.
Chorioamnionitis-induced fetal gut injury is mediated by direct gut exposure of inflammatory mediators or by lung inflammation.
Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins.
Inhibition of PKC-θ preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy.
Anillin regulates cell-cell junction integrity by organizing junctional accumulation of Rho-GTP and actomyosin.
IL-1β and TGF-β weaken the placental barrier through destruction of tight junctions: an in vivo and in vitro study.
E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition.
Perfluorooctanesulfonate (PFOS) perturbs male rat Sertoli cell blood-testis barrier function by affecting F-actin organization via p-FAK-Tyr(407): an in vitro study.
β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier.
Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets.
Intraluminal acid activates esophageal nodose C fibers after mast cell activation.
Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens.
Amelioration of hypoxia and LPS-induced intestinal epithelial barrier dysfunction by emodin through the suppression of the NF-κB and HIF-1α signaling pathways.
PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.
Estrogen receptor alpha deficiency protects against development of cognitive impairment in murine lupus.
ZO proteins redundantly regulate the transcription factor DbpA/ZONAB.
Radial intercalation is regulated by the Par complex and the microtubule-stabilizing protein CLAMP/Spef1.
Pasture v. standard dairy cream in high-fat diet-fed mice: improved metabolic outcomes and stronger intestinal barrier.
Effect of retinoic acid on the tight junctions of the retinal pigment epithelium-choroid complex of guinea pigs with lens-induced myopia in vivo.
Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke.
Novel human renal proximal tubular cell line for the production of complex proteins.
Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea.
Clostridium difficile toxins facilitate bacterial colonization by modulating the fence and gate function of colonic epithelium.
Rai14 (retinoic acid induced protein 14) is involved in regulating f-actin dynamics at the ectoplasmic specialization in the rat testis*.
The transcription factors Tbx18 and Wt1 control the epicardial epithelial-mesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cells.
Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8).
The development of nasal polyp disease involves early nasal mucosal inflammation and remodelling.
The reversible increase in tight junction permeability induced by capsaicin is mediated via cofilin-actin cytoskeletal dynamics and decreased level of occludin.
The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells.
The role of CDX2 in Caco-2 cell differentiation.
Perivascular macrophage-like melanocyte responsiveness to acoustic trauma--a salient feature of strial barrier associated hearing loss.
Retinoic acid promotes Sertoli cell differentiation and antagonises activin-induced proliferation.
E-cadherin supports steady-state Rho signaling at the epithelial zonula adherens.
Prevention of rt-PA induced blood-brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice.
A new human primary epithelial cell culture model to study conjunctival inflammation.
Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain.
Functional principal component analysis reveals discriminating categories of retinal pigment epithelial morphology in mice.
A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth.
An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice.
Palladin is a regulator of actin filament bundles at the ectoplasmic specialization in adult rat testes.
Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state.
Rab25 regulates integrin expression in polarized colonic epithelial cells.
Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice.
PAR2-induced inflammatory responses in human kidney tubular epithelial cells.
Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium.[corrected].
Electromagnetic-pulse-induced activation of p38 MAPK pathway and disruption of blood-retinal barrier.
Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF.
LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation.
Breast cancer resistance protein (Bcrp) and the testis--an unexpected turn of events.
Ameliorative effect of PACAP and VIP against increased permeability in a model of outer blood retinal barrier dysfunction.
c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution.
Zona occludens-2 protects against podocyte dysfunction induced by ADR in mice.
Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies.
Expression of claudins -2 and -4 and cingulin is coordinated with the start of stratification and differentiation in corneal epithelial cells: retinoic acid reversibly disrupts epithelial barrier.
Application of a new wall-less plate technology to complex multistep cell-based investigations using suspension cells.
Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells.
Epicardial function of canonical Wnt-, Hedgehog-, Fgfr1/2-, and Pdgfra-signalling.
Cryo-immunoelectron microscopy of adherent cells improved by the use of electrospun cell culture substrates.
Isolation and culture of endothelial cells, pericytes and perivascular resident macrophage-like melanocytes from the young mouse ear.
Regulation of Toll-like receptors in the choroid plexus in the immature brain after systemic inflammatory stimuli.
Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways.
Endothelial cell, pericyte, and perivascular resident macrophage-type melanocyte interactions regulate cochlear intrastrial fluid-blood barrier permeability.
Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes.
HIV-1 Tat C modulates expression of miRNA-101 to suppress VE-cadherin in human brain microvascular endothelial cells.
Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis.
NC1 domain of collagen α3(IV) derived from the basement membrane regulates Sertoli cell blood-testis barrier dynamics.
Using 32-cell stage Xenopus embryos to probe PCP signaling.
Analysis of the RPE sheet in the rd10 retinal degeneration model.
The T box transcription factor TBX2 promotes epithelial-mesenchymal transition and invasion of normal and malignant breast epithelial cells.
Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases.
Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity.
Py2T murine breast cancer cells, a versatile model of TGFβ-induced EMT in vitro and in vivo.
Identification of new binding partners of the chemosensory signaling protein Gγ13 expressed in taste and olfactory sensory cells.
Notch signaling promotes the corneal epithelium wound healing.
ZO-1 regulates Erk, Smad1/5/8, Smad2, and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells.
Role of tight junction proteins in gastroesophageal reflux disease.
Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration.
Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells.
Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis.
Epiprofin/Sp6 regulates Wnt-BMP signaling and the establishment of cellular junctions during the bell stage of tooth development.
Filamin A is a regulator of blood-testis barrier assembly during postnatal development in the rat testis.
Regulation of the blood-testis barrier by coxsackievirus and adenovirus receptor.
Lentiviral transduction of rat Sertoli cells as a means to modify gene expression.
BMP4 sufficiency to induce choroid plexus epithelial fate from embryonic stem cell-derived neuroepithelial progenitors.
Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.
Differential effects of flavonoids on barrier integrity in human intestinal Caco-2 cells.
Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys.
Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells.
Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid-blood barrier.
Overexpression of the gap junction protein Cx43 as found in diabetic foot ulcers can retard fibroblast migration.
Cx43 associates with Na(v)1.5 in the cardiomyocyte perinexus.
Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat.
Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk.
Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells.
ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium.
Bioartificial Renal Epithelial Cell System (BRECS): A Compact, Cryopreservable Extracorporeal Renal Replacement Device.
AST-120 ameliorates epithelial-to-mesenchymal transition and interstitial fibrosis in the kidneys of chronic kidney disease rats.
Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b.
Multi-cellular rosettes in the mouse visceral endoderm facilitate the ordered migration of anterior visceral endoderm cells.
Good Caco-2 cell culture practices.
Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT).
Tbx18 function in epicardial development.
Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells.
Interferon-gamma signals via an ERK1/2-ARF6 pathway to promote bacterial internalization by gut epithelia.
ETV5 transcription factor is overexpressed in ovarian cancer and regulates cell adhesion in ovarian cancer cells.
Isolation and properties of an in vitro human outer blood-retinal barrier model.
Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor.
Indoxyl sulfate induces epithelial-to-mesenchymal transition in rat kidneys and human proximal tubular cells.
Tight junctions in brain barriers during central nervous system inflammation.
Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke.
Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis.
Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis.
Hepatocyte nuclear factor 4 alpha is associated with mesenchymal-epithelial transition in developing kidneys of C57BL/6 mice.
Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1.
Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function.
Comparison of tight junction protein expression in the ciliary epithelia of mouse, rabbit, cat and human eyes.
Cell growing density affects the structural and functional properties of Caco-2 differentiated monolayer.
Drug transporters and blood--testis barrier function.
Synthetic gelatinases inhibitor attenuates electromagnetic pulse-induced blood-brain barrier disruption by inhibiting gelatinases-mediated ZO-1 degradation in rats.
The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy.
Nodal dependent differential localisation of dishevelled-2 demarcates regions of differing cell behaviour in the visceral endoderm.
ZO-1 determines adherens and gap junction localization at intercalated disks.
Activated Met signalling in the developing mouse heart leads to cardiac disease.
Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage.
14-3-3σ and p63 play opposing roles in epidermal tumorigenesis.
A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination.
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.
Interleukin-1alpha is a regulator of the blood-testis barrier.
IKK1 control of epidermal differentiation is modulated by notch signaling.
Invasive behavior of ulcerative colitis-associated carcinoma is related to reduced expression of CD44 extracellular domain: comparison with sporadic colon carcinoma.
Roles of pre-treatment time and junctional proteins in Caco-2 cell microparticle uptake.
Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo.
Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth.
Effects of long-term progesterone on developmental and functional aspects of porcine uterine epithelia and vasculature: progesterone alone does not support development of uterine glands comparable to that of pregnancy.
Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo.
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis.
Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization.
Responsiveness to PI3K and MEK inhibitors in breast cancer. Use of a 3D culture system to study pathways related to hormone independence in mice.
Mono-(2-ethylhexyl) phthalate-induced disruption of junctional complexes in the seminiferous epithelium of the rodent testis is mediated by MMP2.
Assessing the role of claudins in maintaining the integrity of epididymal tight junctions using novel human epididymal cell lines.
Chlamydia pneumoniae infection in polarized epithelial cell lines.
Epithelial-mesenchymal transition in rhesus monkey embryonic stem cell colonies: the role of culturing conditions.
Gonadotropins regulate rat testicular tight junctions in vivo.
Learning to predict relapse in invasive ductal carcinomas based on the subcellular localization of junctional proteins.
The role of protein kinase C in the opening of blood-brain barrier induced by electromagnetic pulse.
Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching.
The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens.
Arecoline induced disruption of expression and localization of the tight junctional protein ZO-1 is dependent on the HER 2 expression in human endometrial Ishikawa cells.
A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development.
Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells.
Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination.
14-3-3sigma controls corneal epithelial cell proliferation and differentiation through the Notch signaling pathway.
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures.
Macrophages increase microparticle uptake by enterocyte-like Caco-2 cell monolayers.
Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1.
Impairment of intestinal barrier and secretory function as well as egg excretion during intestinal schistosomiasis occur independently of mouse mast cell protease-1.
Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement.
Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain.
A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells.
Impaired transcription factor interplay in addition to advanced glycation end products suppress podocalyxin expression in high glucose-treated human podocytes.
Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis.
The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation.
Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility.
Missense mutations in a retinal pigment epithelium protein, bestrophin-1, cause retinitis pigmentosa.
Disruption of the blood-testis barrier integrity by bisphenol A in vitro: is this a suitable model for studying blood-testis barrier dynamics?
Tight junctions in Hailey-Hailey and Darier's diseases.
The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression.
A novel role for SED1 (MFG-E8) in maintaining the integrity of the epididymal epithelium.
Directed evolution of adeno-associated virus to an infectious respiratory virus.
Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis.
Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction.
Intestinal cytoskeleton degradation precedes tight junction loss following hemorrhagic shock.
Dietary glutamine and oral antibiotics each improve indexes of gut barrier function in rat short bowel syndrome.
Sertoli cell Dicer is essential for spermatogenesis in mice.
Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier.
Expression of tight-junction proteins in the inflamed and clinically uninvolved skin in patients with venous leg ulcers.
Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium.
Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent of ERalpha.
A cell polarity protein aPKClambda is required for eye lens formation and growth.
Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium.
Increased intraocular insulin-like growth factor-I triggers blood-retinal barrier breakdown.
TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury.
Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome.
Rapid reversal of human intestinal ischemia-reperfusion induced damage by shedding of injured enterocytes and reepithelialisation.
Different expression of occludin and ZO-1 in primary and metastatic liver tumors.
Ablation of Cx47 in transgenic mice leads to the loss of MUPP1, ZONAB and multiple connexins at oligodendrocyte-astrocyte gap junctions.
Localization studies of rare missense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) facilitate interpretation of genotype-phenotype relationships.
Postshock intervention with high-lipid enteral nutrition reduces inflammation and tissue damage.
Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke.
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina.
Cellular differentiation in three-dimensional lung cell cultures.
Functional and developmental analysis of the blood-brain barrier in zebrafish.
Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse.
Basolateral entry and release of New and Old World arenaviruses from human airway epithelia.
Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse.
Expression and localisation of apical junctional complex proteins in lens epithelial cells.
Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression.
Localization of claudin-5 and ZO-1 in rat spleen sinus endothelial cells.
Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria.
Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node.
Rapid identification of differentiation markers from whole epithelial cells by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry and statistical analysis.
mRNA expression analysis and the molecular basis of neonatal testis defects in Dmrt1 mutant mice.
Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development.
PINCH-1 promotes tubular epithelial-to-mesenchymal transition by interacting with integrin-linked kinase.
Pathophysiological role of the activation of p38 mitogen-activated protein kinases in poorly differentiated gastric cancer.
Astrovirus increases epithelial barrier permeability independently of viral replication.
Angiopoietin modulation of vascular endothelial growth factor: Effects on retinal endothelial cell permeability.
Localization of ZO-1 in the nucleolus of corneal fibroblasts.
The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation.
Abnormal development of urogenital organs in Dlgh1-deficient mice.
Paracellular permeability restricts airway epithelial responses to selectively allow activation by mediators at the basolateral surface.
ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architecture.
Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis.
Differences in claudin synthesis in primary cultures of acinar cells from rat salivary gland are correlated with the specific three-dimensional organization of the cells.
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy.
Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm.
Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1.
Immunolocalization of tight junction proteins in blood vessels in human germinal matrix and cortex.
Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage.
Establishment of a human in vitro model of the outer blood-retinal barrier.
A large-scale proteomic analysis of human embryonic stem cells.
Spatial relationships of connexin36, connexin57 and zonula occludens-1 in the outer plexiform layer of mouse retina.
Gap junction adhesion is necessary for radial migration in the neocortex.
Derivation and characterization of lentoid bodies and retinal pigment epithelial cells from monkey embryonic stem cells in vitro.
Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins.
Epithelial barrier characteristics and expression of cell adhesion molecules in proximal tubule-derived cell lines commonly used for in vitro toxicity studies.
Characterization of epithelial cell shedding from human small intestine.
Glomerular sclerosis in kidneys with congenital nephrotic syndrome (NPHS1).
Differentiation of adult rat bone marrow stem cells into epithelial progenitor cells in culture.
Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells.
Isolation and characterization of kidney-derived stem cells.
Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins.
Adult sertoli cells are not terminally differentiated in the Djungarian hamster: effect of FSH on proliferation and junction protein organization.
The Coxsackievirus and Adenovirus Receptor: a new adhesion protein in cochlear development.
Endothelia of term human placentae display diminished expression of tight junction proteins during preeclampsia.
Association of connexin36 and zonula occludens-1 with zonula occludens-2 and the transcription factor zonula occludens-1-associated nucleic acid-binding protein at neuronal gap junctions in rodent retina.
CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS.
Establishment and characterization of primary and subsequent subcultures of normal mouse urothelial cells.
Rare incorporation of bone marrow-derived cells into kidney after folic acid-induced injury.
Epithelial barrier function in vivo is sustained despite gaps in epithelial layers.
Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins.
The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex.
Enteropathogenic E. coli disrupts tight junction barrier function and structure in vivo.
Disruption of Sertoli-germ cell adhesion function in the seminiferous epithelium of the rat testis can be limited to adherens junctions without affecting the blood-testis barrier integrity: an in vivo study using an androgen suppression model.
Drebrin, an actin-binding, cell-type characteristic protein: induction and localization in epithelial skin tumors and cultured keratinocytes.
The short apical membrane half-life of rescued {Delta}F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of {Delta}F508-CFTR in polarized human airway epithelial cells.
Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina.
Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells.
Ultrastructural and immunohistochemical characterization of the bovine epiblast.
sPAR-3, a splicing variant of PAR-3, shows cellular localization and an expression pattern different from that of PAR-3 during enterocyte polarization.
Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells.
Amphiregulin causes functional downregulation of adherens junctions in psoriasis.
Epithelial-mesenchymal transition in colonies of rhesus monkey embryonic stem cells: a model for processes involved in gastrulation.
Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier.
Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain.
Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion.
Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner.
Lactobacillus acidophilus protects tight junctions from aspirin damage in HT-29 cells.
Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro.
Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression.
Isoforms of the polarity protein par6 have distinct functions.
Association of connexin36 with zonula occludens-1 in HeLa cells, betaTC-3 cells, pancreas, and adrenal gland.
The rotavirus surface protein VP8 modulates the gate and fence function of tight junctions in epithelial cells.
Activin A and follicle-stimulating hormone control tight junctions in avian granulosa cells by regulating occludin expression.
Endothelia of Schlemm's canal and trabecular meshwork: distinct molecular, functional, and anatomic features.
A novel four transmembrane spanning protein, CLP24. A hypoxically regulated cell junction protein.
Characterization of the tight junction protein ZO-2 localized at the nucleus of epithelial cells.
Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment.
Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells.
Identification of PKCzetaII: an endogenous inhibitor of cell polarity.
Oxidative stress affects the junctional integrity of retinal pigment epithelial cells.
Oxidative stress affects the junctional integrity of retinal pigment epithelial cells.
Mechanism of recruiting Sec6/8 (exocyst) complex to the apical junctional complex during polarization of epithelial cells.
Expression and function of tight junctions in the crypt epithelium of human palatine tonsils.
Histone deacetylase inhibitors up-regulate the expression of tight junction proteins.
Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium.
Tight junction-associated proteins (occludin, ZO-1, claudin-1, claudin-4) in squamous cell carcinoma and Bowen's disease.
Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1.
The specific fates of tight junction proteins in apoptotic epithelial cells.
Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells.
Role of claudin interactions in airway tight junctional permeability.
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells.
Role of catenins in the development of gap junctions in rat cardiomyocytes.
The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.
Nectin-dependent localization of ZO-1 at puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 area of adult mouse hippocampus.
Age-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1).
Age-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1).
Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.
Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins.
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms.
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms.
Immunohistological distribution of the tight junction components ZO-1 and occludin in regenerating human epidermis.
Immunohistological distribution of the tight junction components ZO-1 and occludin in regenerating human epidermis.
Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in the Caco-2 cell monolayer.
2,3-butanedione monoxime (BDM), a potent inhibitor of actin-myosin interaction, induces ion and fluid transport in MDCK monolayers.
2,3-butanedione monoxime (BDM), a potent inhibitor of actin-myosin interaction, induces ion and fluid transport in MDCK monolayers.
Applications of epithelial cell culture in studies of drug transport.
Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells.
Diabetes-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1) expression.
Diabetes-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1) expression.
Hepatocyte polarity and the peroxisomal compartment: a comparative study.
E-Cadherin and tight junctions between epithelial cells of different animal species.
Tight junctions are sensitive to peptides eliminated in the urine.
Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways.
JEAP, a novel component of tight junctions in exocrine cells.
Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin.
cAMP-dependent protein kinase and proliferation differ in normal and polycystic kidney epithelia.
Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions.
Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes.
Long-term natural culture of cochlear sensory epithelia of guinea pigs.
Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells.
Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression.
Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression.
Integrity of epithelium and endothelium in organ-cultured human corneas.
Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.
Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.
The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction.
Saccharomyces boulardii preserves the barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli-infected T84 cells.
Molecular physiology and pathophysiology of tight junctions III. Tight junction regulation by intracellular messengers: differences in response within and between epithelia.
Potential biological role of transforming growth factor-beta1 in human congenital kidney malformations.
Potential biological role of transforming growth factor-beta1 in human congenital kidney malformations.
Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology.
Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology.
Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells.
Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells.
Tight junction proteins ZO-1, ZO-2, and occludin along isolated renal tubules.
A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation.
Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas.
Relationship between Na(+),K(+)-ATPase and cell attachment.
Relationship between Na(+),K(+)-ATPase and cell attachment.
Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin.
Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin.
ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin.
ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin.
Occludin confers adhesiveness when expressed in fibroblasts.
Occludin confers adhesiveness when expressed in fibroblasts.
Manganese and other trace elements in urban snow near an expressway.
The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.
The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.
The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.
Two classes of tight junctions are revealed by ZO-1 isoforms.
Two classes of tight junctions are revealed by ZO-1 isoforms.
Karwelat D, Kühnlenz J, Steger-Hartmann T, Bars R, Tinwell H, Marx U, Bauer S, Born O, Raschke M
ALTEX 2023;40(1):83-102
ALTEX 2023;40(1):83-102
Altered Differentiation and Inflammation Profiles Contribute to Enhanced Innate Responses in Severe COPD Epithelium to Rhinovirus Infection.
Guo-Parke H, Linden D, Mousnier A, Scott IC, Killick H, Borthwick LA, Fisher AJ, Weldon S, Taggart CC, Kidney JC
Frontiers in medicine 2022;9:741989
Frontiers in medicine 2022;9:741989
Intravenous transplantation of amnion-derived mesenchymal stem cells promotes functional recovery and alleviates intestinal dysfunction after spinal cord injury.
Takamiya S, Kawabori M, Yamazaki K, Yamaguchi S, Tanimori A, Yamamoto K, Ohnishi S, Seki T, Konno K, Tha KK, Hashimoto D, Watanabe M, Houkin K, Fujimura M
PloS one 2022;17(7):e0270606
PloS one 2022;17(7):e0270606
Collagen triple helix repeat containing-1 promotes functional recovery of sweat glands by inducing adjacent microvascular network reconstruction in vivo.
Yuan X, Duan X, Li Z, Yao B, Enhejirigala, Song W, Kong Y, Wang Y, Zhang F, Liang L, Zhu S, Zhang M, Zhang C, Huang S, Fu X
Burns & trauma 2022;10:tkac035
Burns & trauma 2022;10:tkac035
Evaluation of Caco-2 and human intestinal epithelial cells as in vitro models of colonic and small intestinal integrity.
Lopez-Escalera S, Wellejus A
Biochemistry and biophysics reports 2022 Sep;31:101314
Biochemistry and biophysics reports 2022 Sep;31:101314
CDCP1 regulates retinal pigmented epithelial barrier integrity for the development of experimental autoimmune uveitis.
Zhang L, Borjini N, Lun Y, Parab S, Asonye G, Singh R, Bell BA, Bonilha VL, Ivanov A, Fox DA, Caspi RR, Lin F
JCI insight 2022 Sep 22;7(18)
JCI insight 2022 Sep 22;7(18)
SARS-CoV-2 spike S1 subunit protein-mediated increase of beta-secretase 1 (BACE1) impairs human brain vessel cells.
Choi JY, Park JH, Jo C, Kim KC, Koh YH
Biochemical and biophysical research communications 2022 Oct 20;626:66-71
Biochemical and biophysical research communications 2022 Oct 20;626:66-71
Spermine protects intestinal barrier integrity through ras-related C3 botulinum toxin substrate 1/phospholipase C-γ1 signaling pathway in piglets.
Liu G, Xu X, Wu C, Jia G, Zhao H, Chen X, Tian G, Cai J, Wang J
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Mar;8(1):135-143
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Mar;8(1):135-143
Glycine represses endoplasmic reticulum stress-related apoptosis and improves intestinal barrier by activating mammalian target of rapamycin complex 1 signaling.
Yang Y, Fan X, Ji Y, Li J, Dai Z, Wu Z
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Mar;8(1):1-9
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Mar;8(1):1-9
Addition of Chk1 inhibitor and BMP4 cooperatively promotes retinal tissue formation in self-organizing human pluripotent stem cell differentiation culture.
Yamasaki S, Kuwahara A, Kishino A, Kimura T, Takahashi M, Mandai M
Regenerative therapy 2022 Mar;19:24-34
Regenerative therapy 2022 Mar;19:24-34
Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells.
Klingler S, Hsu KS, Hua G, Martin ML, Adileh M, Baslan T, Zhang Z, Paty PB, Fuks Z, Brown AM, Kolesnick R
JCI insight 2022 Mar 8;7(5)
JCI insight 2022 Mar 8;7(5)
Endothelial Unc5B controls blood-brain barrier integrity.
Boyé K, Geraldo LH, Furtado J, Pibouin-Fragner L, Poulet M, Kim D, Nelson B, Xu Y, Jacob L, Maissa N, Agalliu D, Claesson-Welsh L, Ackerman SL, Eichmann A
Nature communications 2022 Mar 4;13(1):1169
Nature communications 2022 Mar 4;13(1):1169
Dl-3-n-butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance.
Song K, Zeng X, Xie X, Zhu R, Liang J, Chen G, Huang L
Stroke and vascular neurology 2022 Jun;7(3):222-236
Stroke and vascular neurology 2022 Jun;7(3):222-236
Blocking C3d(+)/GFAP(+) A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke.
Zhang Q, Liu C, Shi R, Zhou S, Shan H, Deng L, Chen T, Guo Y, Zhang Z, Yang GY, Wang Y, Tang Y
Aging and disease 2022 Jun;13(3):943-959
Aging and disease 2022 Jun;13(3):943-959
Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood-brain barrier integrity.
Liu L, Yang C, Lavayen BP, Tishko RJ, Larochelle J, Candelario-Jalil E
Journal of neuroinflammation 2022 Jun 27;19(1):168
Journal of neuroinflammation 2022 Jun 27;19(1):168
Immortalized human choroid plexus endothelial cells enable an advanced endothelial-epithelial two-cell type in vitro model of the choroid plexus.
Muranyi W, Schwerk C, Herold R, Stump-Guthier C, Lampe M, Fallier-Becker P, Weiß C, Sticht C, Ishikawa H, Schroten H
iScience 2022 Jun 17;25(6):104383
iScience 2022 Jun 17;25(6):104383
DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction.
Chou HC, Cheng CM, Yang CH, Lin TY, Liu YW, Tan TH, Chen YR
Journal of biomedical science 2022 Jun 15;29(1):40
Journal of biomedical science 2022 Jun 15;29(1):40
Murine in utero exposure to simulated complex urban air pollution disturbs offspring gut maturation and microbiota during intestinal suckling-to-weaning transition in a sex-dependent manner.
Guilloteau E, Coll P, Lu Z, Djouina M, Cazaunau M, Waxin C, Bergé A, Caboche S, Gratien A, Al Marj E, Hot D, Dubuquoy L, Launay D, Vignal C, Lanone S, Body-Malapel M
Particle and fibre toxicology 2022 Jun 15;19(1):41
Particle and fibre toxicology 2022 Jun 15;19(1):41
CU06-1004 enhances vascular integrity and improves cardiac remodeling by suppressing edema and inflammation in myocardial ischemia-reperfusion injury.
Zhang H, Kim H, Park BW, Noh M, Kim Y, Park J, Park JH, Kim JJ, Sim WS, Ban K, Park HJ, Kwon YG
Experimental & molecular medicine 2022 Jan;54(1):23-34
Experimental & molecular medicine 2022 Jan;54(1):23-34
ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro.
Marchetti L, Francisco D, Soldati S, Haghayegh Jahromi N, Barcos S, Gruber I, Pareja JR, Thiriot A, von Andrian U, Deutsch U, Lyck R, Bruggmann R, Engelhardt B
European journal of immunology 2022 Jan;52(1):161-177
European journal of immunology 2022 Jan;52(1):161-177
Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium.
Gagliardi TB, Goldstein ME, Song D, Gray KM, Jung JW, Ignacio MA, Stroka KM, Duncan GA, Scull MA
PLoS pathogens 2022 Jan;18(1):e1010159
PLoS pathogens 2022 Jan;18(1):e1010159
Engineered human blood-brain barrier microfluidic model for vascular permeability analyses.
Hajal C, Offeddu GS, Shin Y, Zhang S, Morozova O, Hickman D, Knutson CG, Kamm RD
Nature protocols 2022 Jan;17(1):95-128
Nature protocols 2022 Jan;17(1):95-128
A Novel In Vitro Membrane Permeability Methodology Using Three-dimensional Caco-2 Tubules in a Microphysiological System Which Better Mimics In Vivo Physiological Conditions.
Hagiwara Y, Kumagai H, Ouwerkerk N, Gijzen L, Annida R, Bokkers M, van Vught R, Yoshinari K, Katakawa Y, Motonaga K, Tajiri T
Journal of pharmaceutical sciences 2022 Jan;111(1):214-224
Journal of pharmaceutical sciences 2022 Jan;111(1):214-224
Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity.
Wong SL, Awatade NT, Astore MA, Allan KM, Carnell MJ, Slapetova I, Chen PC, Capraro A, Fawcett LK, Whan RM, Griffith R, Ooi CY, Kuyucak S, Jaffe A, Waters SA
iScience 2022 Jan 21;25(1):103710
iScience 2022 Jan 21;25(1):103710
High-throughput formation and image-based analysis of basal-in mammary organoids in 384-well plates.
Lee S, Chang J, Kang SM, Parigoris E, Lee JH, Huh YS, Takayama S
Scientific reports 2022 Jan 10;12(1):317
Scientific reports 2022 Jan 10;12(1):317
Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice.
Yu R, Kim NS, Li Y, Jeong JY, Park SJ, Zhou B, Oh WJ
Translational stroke research 2022 Feb;13(1):142-159
Translational stroke research 2022 Feb;13(1):142-159
T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model.
El-Hindi K, Brachtendorf S, Hartel JC, Oertel S, Birod K, Merz N, Trautmann S, Thomas D, Weigert A, Schäufele TJ, Scholich K, Schiffmann S, Ulshöfer T, Utermöhlen O, Grösch S
International journal of molecular sciences 2022 Feb 7;23(3)
International journal of molecular sciences 2022 Feb 7;23(3)
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu.
Williams LM, Fujimoto T, Weaver RR, Logsdon AF, Evitts KM, Young JE, Banks WA, Erickson MA
Fluids and barriers of the CNS 2022 Feb 5;19(1):10
Fluids and barriers of the CNS 2022 Feb 5;19(1):10
Blood-brain barrier dysfunction in L-ornithine induced acute pancreatitis in rats and the direct effect of L-ornithine on cultured brain endothelial cells.
Walter FR, Harazin A, Tóth AE, Veszelka S, Santa-Maria AR, Barna L, Kincses A, Biczó G, Balla Z, Kui B, Maléth J, Cervenak L, Tubak V, Kittel Á, Rakonczay Z Jr, Deli MA
Fluids and barriers of the CNS 2022 Feb 17;19(1):16
Fluids and barriers of the CNS 2022 Feb 17;19(1):16
Rifaximin enhances the L‑carnitine‑mediated preventive effects on skeletal muscle atrophy in cirrhotic rats by modulating the gut‑liver‑muscle axis.
Murata K, Kaji K, Nishimura N, Enomoto M, Fujimoto Y, Takeda S, Tsuji Y, Fujinaga Y, Takaya H, Kawaratani H, Namisaki T, Akahane T, Yoshiji H
International journal of molecular medicine 2022 Aug;50(2)
International journal of molecular medicine 2022 Aug;50(2)
Mucin O-glycan-microbiota axis orchestrates gut homeostasis in a diarrheal pig model.
Xia B, Zhong R, Wu W, Luo C, Meng Q, Gao Q, Zhao Y, Chen L, Zhang S, Zhao X, Zhang H
Microbiome 2022 Aug 31;10(1):139
Microbiome 2022 Aug 31;10(1):139
Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice.
Azuma K, Koumura T, Iwamoto R, Matsuoka M, Terauchi R, Yasuda S, Shiraya T, Watanabe S, Aihara M, Imai H, Ueta T
The Journal of biological chemistry 2022 Apr;298(4):101824
The Journal of biological chemistry 2022 Apr;298(4):101824
A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds.
Yuan Y, Leiby KL, Greaney AM, Raredon MSB, Qian H, Schupp JC, Engler AJ, Baevova P, Adams TS, Kural MH, Wang J, Obata T, Yoder MC, Kaminski N, Niklason LE
Frontiers in bioengineering and biotechnology 2021;9:760309
Frontiers in bioengineering and biotechnology 2021;9:760309
Diosmin Alleviates Venous Injury and Muscle Damage in a Mouse Model of Iliac Vein Stenosis.
Guo Z, Du X, Zhang Y, Su C, Ran F, Lu Q
Frontiers in cardiovascular medicine 2021;8:785554
Frontiers in cardiovascular medicine 2021;8:785554
Fractalkine Is Linked to the Necrosome Pathway in Acute Pulmonary Inflammation.
Ngamsri KC, Gamper-Tsigaras J, Reutershan J, Konrad FM
Frontiers in medicine 2021;8:591790
Frontiers in medicine 2021;8:591790
The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress.
Dorion MF, Mulumba M, Kasai S, Itoh K, Lubell WD, Ong H
Oxidative medicine and cellular longevity 2021;2021:6691402
Oxidative medicine and cellular longevity 2021;2021:6691402
Lycium barbarum Polysaccharide Ameliorates Heat-Stress-Induced Impairment of Primary Sertoli Cells and the Blood-Testis Barrier in Rat via Androgen Receptor and Akt Phosphorylation.
Hu S, Liu D, Liu S, Li C, Guo J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5574202
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5574202
The blood-brain barrier studied in vitro across species.
Thomsen MS, Humle N, Hede E, Moos T, Burkhart A, Thomsen LB
PloS one 2021;16(3):e0236770
PloS one 2021;16(3):e0236770
Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C.
Van Hoecke L, Van Cauwenberghe C, Dominko K, Van Imschoot G, Van Wonterghem E, Castelein J, Xie J, Claeys W, Vandendriessche C, Kremer A, Borghgraef P, De Rycke R, Hecimovic S, Vandenbroucke RE
Frontiers in cellular neuroscience 2021;15:757482
Frontiers in cellular neuroscience 2021;15:757482
Characterization of Leptin Receptor(+) Stromal Cells in Lymph Node.
Jiang L, Yilmaz M, Uehara M, Cavazzoni CB, Kasinath V, Zhao J, Naini SM, Li X, Banouni N, Fiorina P, Shin SR, Tullius SG, Bromberg JS, Sage PT, Abdi R
Frontiers in immunology 2021;12:730438
Frontiers in immunology 2021;12:730438
Recombinant Annexin A2 Administration Improves Neurological Outcomes After Traumatic Brain Injury in Mice.
Cheng C, Wang X, Jiang Y, Li Y, Liao Z, Li W, Yu Z, Whalen MJ, Lok J, Dumont AS, Liu N, Wang X
Frontiers in pharmacology 2021;12:708469
Frontiers in pharmacology 2021;12:708469
Early-Life Intervention Using Exogenous Fecal Microbiota Alleviates Gut Injury and Reduce Inflammation Caused by Weaning Stress in Piglets.
Ma X, Zhang Y, Xu T, Qian M, Yang Z, Zhan X, Han X
Frontiers in microbiology 2021;12:671683
Frontiers in microbiology 2021;12:671683
Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis.
Dong X, Lei Y, Yu Z, Wang T, Liu Y, Han G, Zhang X, Li Y, Song Y, Xu H, Du M, Yin H, Wang X, Yan H
Theranostics 2021;11(11):5107-5126
Theranostics 2021;11(11):5107-5126
Voiding defects in acute radiation cystitis driven by urothelial barrier defect through loss of E-cadherin, ZO-1 and Uroplakin III.
Zwaans BMM, Carabulea AL, Bartolone SN, Ward EP, Chancellor MB, Lamb LE
Scientific reports 2021 Sep 29;11(1):19277
Scientific reports 2021 Sep 29;11(1):19277
Zonula occludens 2 and Cell-Cell Contacts Are Required for Normal Nuclear Shape in Epithelia.
Hernández-Guzmán C, Gallego-Gutiérrez H, Chávez-Munguía B, Martín-Tapia D, González-Mariscal L
Cells 2021 Sep 28;10(10)
Cells 2021 Sep 28;10(10)
FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells.
Kamasaki T, Miyazaki Y, Ishikawa S, Hoshiba K, Kuromiya K, Tanimura N, Mori Y, Tsutsumi M, Nemoto T, Uehara R, Suetsugu S, Itoh T, Fujita Y
iScience 2021 Sep 24;24(9):102994
iScience 2021 Sep 24;24(9):102994
Extracorporeal Shock Wave Enhances the Cisplatin Efficacy by Improving Tissue Infiltration and Cellular Uptake in an Upper Urinary Tract Cancer Animal and Human-Derived Organoid Model.
Luo HL, Liu HY, Chang YL, Su YL, Huang CC, Lin XJ, Chuang YC
Cancers 2021 Sep 11;13(18)
Cancers 2021 Sep 11;13(18)
Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception.
Dalghi MG, Ruiz WG, Clayton DR, Montalbetti N, Daugherty SL, Beckel JM, Carattino MD, Apodaca G
JCI insight 2021 Oct 8;6(19)
JCI insight 2021 Oct 8;6(19)
Altered Mucus Barrier Integrity and Increased Susceptibility to Colitis in Mice upon Loss of Telocyte Bone Morphogenetic Protein Signalling.
Reyes Nicolás V, Allaire JM, Alfonso AB, Pupo Gómez D, Pomerleau V, Giroux V, Boudreau F, Perreault N
Cells 2021 Oct 29;10(11)
Cells 2021 Oct 29;10(11)
Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.
Junqueira Alves C, Dariolli R, Haydak J, Kang S, Hannah T, Wiener RJ, DeFronzo S, Tejero R, Gusella GL, Ramakrishnan A, Alves Dias R, Wojcinski A, Kesari S, Shen L, Sobie EA, Rodrigues Furtado de Mendonça JP, Azeloglu EU, Zou H, Friedel RH
Nature communications 2021 Oct 14;12(1):6019
Nature communications 2021 Oct 14;12(1):6019
The expression, localisation and interactome of pigeon CRY2.
Balay SD, Hochstoeger T, Vilceanu A, Malkemper EP, Snider W, Dürnberger G, Mechtler K, Schuechner S, Ogris E, Nordmann GC, Ushakova L, Nimpf S, Keays DA
Scientific reports 2021 Oct 13;11(1):20293
Scientific reports 2021 Oct 13;11(1):20293
Metallothionein 2 activation by pravastatin reinforces epithelial integrity and ameliorates radiation-induced enteropathy.
Kwak SY, Jang WI, Park S, Cho SS, Lee SB, Kim MJ, Park S, Shim S, Jang H
EBioMedicine 2021 Nov;73:103641
EBioMedicine 2021 Nov;73:103641
Single-Cell Transcriptomics Analysis of Human Small Antral Follicles.
Fan X, Moustakas I, Bialecka M, Del Valle JS, Overeem AW, Louwe LA, Pilgram GSK, van der Westerlaken LAJ, Mei H, Chuva de Sousa Lopes SM
International journal of molecular sciences 2021 Nov 4;22(21)
International journal of molecular sciences 2021 Nov 4;22(21)
Expression of E-Cadherin in Epithelial Cancer Cells Increases Cell Motility and Directionality through the Localization of ZO-1 during Collective Cell Migration.
Park SY, Jang H, Kim SY, Kim D, Park Y, Kee SH
Bioengineering (Basel, Switzerland) 2021 May 11;8(5)
Bioengineering (Basel, Switzerland) 2021 May 11;8(5)
Small extracellular vesicles ameliorate peripheral neuropathy and enhance chemotherapy of oxaliplatin on ovarian cancer.
Zhang Y, Li C, Qin Y, Cepparulo P, Millman M, Chopp M, Kemper A, Szalad A, Lu X, Wang L, Zhang ZG
Journal of extracellular vesicles 2021 Mar;10(5):e12073
Journal of extracellular vesicles 2021 Mar;10(5):e12073
Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels.
Huang X, Oshima T, Tomita T, Fukui H, Miwa H
Biology 2021 Mar 9;10(3)
Biology 2021 Mar 9;10(3)
Automating Human Induced Pluripotent Stem Cell Culture and Differentiation of iPSC-Derived Retinal Pigment Epithelium for Personalized Drug Testing.
Truong V, Viken K, Geng Z, Barkan S, Johnson B, Ebeling MC, Montezuma SR, Ferrington DA, Dutton JR
SLAS technology 2021 Jun;26(3):287-299
SLAS technology 2021 Jun;26(3):287-299
Expression pattern and prognostic impact of glycoprotein non-metastatic B (GPNMB) in triple-negative breast cancer.
Huang YH, Chu PY, Chen JL, Huang CT, Huang CC, Tsai YF, Wang YL, Lien PJ, Tseng LM, Liu CY
Scientific reports 2021 Jun 9;11(1):12171
Scientific reports 2021 Jun 9;11(1):12171
Cerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals.
Kozma M, Mészáros Á, Nyúl-Tóth Á, Molnár K, Costea L, Hernádi Z, Fazakas C, Farkas AE, Wilhelm I, Krizbai IA
International journal of molecular sciences 2021 Jun 6;22(11)
International journal of molecular sciences 2021 Jun 6;22(11)
A defined subset of clonal retinal stem cell spheres is biased to RPE differentiation.
Baakdhah TW, Coles B, van der Kooy D
iScience 2021 Jun 25;24(6):102574
iScience 2021 Jun 25;24(6):102574
The Role of Processed Aloe vera Gel in Intestinal Tight Junction: An In Vivo and In Vitro Study.
Le Phan TH, Park SY, Jung HJ, Kim MW, Cho E, Shim KS, Shin E, Yoon JH, Maeng HJ, Kang JH, Oh SH
International journal of molecular sciences 2021 Jun 17;22(12)
International journal of molecular sciences 2021 Jun 17;22(12)
Cordycepin confers long-term neuroprotection via inhibiting neutrophil infiltration and neuroinflammation after traumatic brain injury.
Wei P, Wang K, Luo C, Huang Y, Misilimu D, Wen H, Jin P, Li C, Gong Y, Gao Y
Journal of neuroinflammation 2021 Jun 15;18(1):137
Journal of neuroinflammation 2021 Jun 15;18(1):137
MAGI-1 PDZ2 Domain Blockade Averts Adenovirus Infection via Enhanced Proteolysis of the Apical Coxsackievirus and Adenovirus Receptor.
Alghamri MS, Sharma P, Williamson TL, Readler JM, Yan R, Rider SD Jr, Hostetler HA, Cool DR, Kolawole AO, Excoffon KJDA
Journal of virology 2021 Jun 10;95(13):e0004621
Journal of virology 2021 Jun 10;95(13):e0004621
Apical CLC-2 in retinal pigment epithelium is crucial for survival of the outer retina.
Hanke-Gogokhia C, Lehmann GL, Benedicto I, de la Fuente-Ortega E, Arshavsky VY, Schreiner R, Rodriguez-Boulan E
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jul;35(7):e21689
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jul;35(7):e21689
Clarithromycin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage via Suppressing Periostin-Related Pathways in Mice.
Kanamaru H, Kawakita F, Nishikawa H, Nakano F, Asada R, Suzuki H
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Jul;18(3):1880-1890
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Jul;18(3):1880-1890
Planar cell polarity induces local microtubule bundling for coordinated ciliary beating.
Nakayama S, Yano T, Namba T, Konishi S, Takagishi M, Herawati E, Nishida T, Imoto Y, Ishihara S, Takahashi M, Furuta K, Oiwa K, Tamura A, Tsukita S
The Journal of cell biology 2021 Jul 5;220(7)
The Journal of cell biology 2021 Jul 5;220(7)
The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia.
Kozawa K, Sekai M, Ohba K, Ito S, Sako H, Maruyama T, Kakeno M, Shirai T, Kuromiya K, Kamasaki T, Kohashi K, Tanaka S, Ishikawa S, Sato N, Asano S, Suzuki H, Tanimura N, Mukai Y, Gotoh N, Tanino M, Tanaka S, Natsuga K, Soga T, Nakamura T, Yabuta Y, Saitou M, Ito T, Matsuura K, Tsunoda M, Kikumori T, Iida T, Mizutani Y, Miyai Y, Kaibuchi K, Enomoto A, Fujita Y
Current biology : CB 2021 Jul 26;31(14):3086-3097.e7
Current biology : CB 2021 Jul 26;31(14):3086-3097.e7
NLRP3 inhibition attenuates early brain injury and delayed cerebral vasospasm after subarachnoid hemorrhage.
Dodd WS, Noda I, Martinez M, Hosaka K, Hoh BL
Journal of neuroinflammation 2021 Jul 20;18(1):163
Journal of neuroinflammation 2021 Jul 20;18(1):163
Alveolar epithelial glycocalyx shedding aggravates the epithelial barrier and disrupts epithelial tight junctions in acute respiratory distress syndrome.
Li J, Qi Z, Li D, Huang X, Qi B, Feng J, Qu J, Wang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111026
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111026
ATPIF1 maintains normal mitochondrial structure which is impaired by CCM3 deficiency in endothelial cells.
Wang K, Chen H, Zhou Z, Zhang H, Zhou HJ, Min W
Cell & bioscience 2021 Jan 9;11(1):11
Cell & bioscience 2021 Jan 9;11(1):11
Structural disruption of the blood-brain barrier in repetitive primary blast injury.
Uzunalli G, Herr S, Dieterly AM, Shi R, Lyle LT
Fluids and barriers of the CNS 2021 Jan 7;18(1):2
Fluids and barriers of the CNS 2021 Jan 7;18(1):2
Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial-mesenchymal transition by targeting HOXC6.
Li D, Zhang J, Liu Z, Gong Y, Zheng Z
Stem cell research & therapy 2021 Jan 7;12(1):24
Stem cell research & therapy 2021 Jan 7;12(1):24
Dynamic conversion of cell sorting patterns in aggregates of embryonic stem cells with differential adhesive affinity.
Tse JD, Moore R, Meng Y, Tao W, Smith ER, Xu XX
BMC developmental biology 2021 Jan 6;21(1):2
BMC developmental biology 2021 Jan 6;21(1):2
Quercetin Alleviates Oxidative Damage by Activating Nuclear Factor Erythroid 2-Related Factor 2 Signaling in Porcine Enterocytes.
Jia H, Zhang Y, Si X, Jin Y, Jiang D, Dai Z, Wu Z
Nutrients 2021 Jan 26;13(2)
Nutrients 2021 Jan 26;13(2)
Citrus limon Peel Powder Reduces Intestinal Barrier Defects and Inflammation in a Colitic Murine Experimental Model.
Tinh NTT, Sitolo GC, Yamamoto Y, Suzuki T
Foods (Basel, Switzerland) 2021 Jan 25;10(2)
Foods (Basel, Switzerland) 2021 Jan 25;10(2)
Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE.
Viheriälä T, Sorvari J, Ihalainen TO, Mörö A, Grönroos P, Schlie-Wolter S, Chichkov B, Skottman H, Nymark S, Ilmarinen T
Scientific reports 2021 Jan 13;11(1):933
Scientific reports 2021 Jan 13;11(1):933
Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing.
Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K
Nature biomedical engineering 2021 Feb;5(2):169-178
Nature biomedical engineering 2021 Feb;5(2):169-178
ILC1 drive intestinal epithelial and matrix remodelling.
Jowett GM, Norman MDA, Yu TTL, Rosell Arévalo P, Hoogland D, Lust ST, Read E, Hamrud E, Walters NJ, Niazi U, Chung MWH, Marciano D, Omer OS, Zabinski T, Danovi D, Lord GM, Hilborn J, Evans ND, Dreiss CA, Bozec L, Oommen OP, Lorenz CD, da Silva RMP, Neves JF, Gentleman E
Nature materials 2021 Feb;20(2):250-259
Nature materials 2021 Feb;20(2):250-259
The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα.
Bai H, Zhou R, Barravecchia M, Norman R, Friedman A, Yu D, Lin X, Young JL, Dean DA
JCI insight 2021 Feb 22;6(4)
JCI insight 2021 Feb 22;6(4)
Epithelial-Specific TLR4 Knockout Challenges Current Evidence of TLR4 Homeostatic Control of Gut Permeability.
Crame EE, Bowen JM, Secombe KR, Coller JK, François M, Leifert W, Wardill HR
Inflammatory intestinal diseases 2021 Dec;6(4):199-209
Inflammatory intestinal diseases 2021 Dec;6(4):199-209
KRT8 (keratin 8) attenuates necrotic cell death by facilitating mitochondrial fission-mediated mitophagy through interaction with PLEC (plectin).
Baek A, Son S, Baek YM, Kim DE
Autophagy 2021 Dec;17(12):3939-3956
Autophagy 2021 Dec;17(12):3939-3956
Silencing of lncRNA XIST impairs angiogenesis and exacerbates cerebral vascular injury after ischemic stroke.
Wang C, Dong J, Sun J, Huang S, Wu F, Zhang X, Pang D, Fu Y, Li L
Molecular therapy. Nucleic acids 2021 Dec 3;26:148-160
Molecular therapy. Nucleic acids 2021 Dec 3;26:148-160
Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrity.
Fujimoto Y, Kaji K, Nishimura N, Enomoto M, Murata K, Takeda S, Takaya H, Kawaratani H, Moriya K, Namisaki T, Akahane T, Yoshiji H
World journal of gastroenterology 2021 Dec 28;27(48):8323-8342
World journal of gastroenterology 2021 Dec 28;27(48):8323-8342
Nano-scale architecture of blood-brain barrier tight-junctions.
Sasson E, Anzi S, Bell B, Yakovian O, Zorsky M, Deutsch U, Engelhardt B, Sherman E, Vatine G, Dzikowski R, Ben-Zvi A
eLife 2021 Dec 24;10
eLife 2021 Dec 24;10
NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood-brain barrier integrity in murine stroke.
Bellut M, Papp L, Bieber M, Kraft P, Stoll G, Schuhmann MK
Cell death & disease 2021 Dec 20;13(1):20
Cell death & disease 2021 Dec 20;13(1):20
The laminin-binding integrins regulate nuclear factor κB-dependent epithelial cell polarity and inflammation.
Yazlovitskaya EM, Plosa E, Bock F, Viquez OM, Mernaugh G, Gewin LS, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Blackwell TS, Pozzi A, Zent R
Journal of cell science 2021 Dec 15;134(24)
Journal of cell science 2021 Dec 15;134(24)
Unravelling the Role of PAX2 Mutation in Human Focal Segmental Glomerulosclerosis.
Longaretti L, Trionfini P, Brizi V, Xinaris C, Mele C, Breno M, Romano E, Giampietro R, Remuzzi G, Benigni A, Tomasoni S
Biomedicines 2021 Dec 1;9(12)
Biomedicines 2021 Dec 1;9(12)
Long noncoding RNA ERLR mediates epithelial-mesenchymal transition of retinal pigment epithelial cells and promotes experimental proliferative vitreoretinopathy.
Yang S, Li H, Yao H, Zhang Y, Bao H, Wu L, Zhang C, Li M, Feng L, Zhang J, Zheng Z, Xu G, Wang F
Cell death and differentiation 2021 Aug;28(8):2351-2366
Cell death and differentiation 2021 Aug;28(8):2351-2366
Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function.
Yamamuro T, Nakamura S, Yamano Y, Endo T, Yanagawa K, Tokumura A, Matsumura T, Kobayashi K, Mori H, Enokidani Y, Yoshida G, Imoto H, Kawabata T, Hamasaki M, Kuma A, Kuribayashi S, Takezawa K, Okada Y, Ozawa M, Fukuhara S, Shinohara T, Ikawa M, Yoshimori T
PLoS genetics 2021 Aug;17(8):e1009688
PLoS genetics 2021 Aug;17(8):e1009688
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.
Eze UC, Bhaduri A, Haeussler M, Nowakowski TJ, Kriegstein AR
Nature neuroscience 2021 Apr;24(4):584-594
Nature neuroscience 2021 Apr;24(4):584-594
Permissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease.
Chen B, Wang P, Liang X, Jiang C, Ge Y, Dworkin LD, Gong R
Cell death & disease 2021 Apr 30;12(5):432
Cell death & disease 2021 Apr 30;12(5):432
Genomic diversity contributes to the neuroinvasiveness of the Yellow fever French neurotropic vaccine.
Bakoa F, Préhaud C, Beauclair G, Chazal M, Mantel N, Lafon M, Jouvenet N
NPJ vaccines 2021 Apr 26;6(1):64
NPJ vaccines 2021 Apr 26;6(1):64
Transport of Dietary Anti-Inflammatory Peptide, γ-Glutamyl Valine (γ-EV), across the Intestinal Caco-2 Monolayer.
Guha S, Alvarez S, Majumder K
Nutrients 2021 Apr 24;13(5)
Nutrients 2021 Apr 24;13(5)
Transverse aortic constriction induces gut barrier alterations, microbiota remodeling and systemic inflammation.
Boccella N, Paolillo R, Coretti L, D'Apice S, Lama A, Giugliano G, Schiattarella GG, Cuomo M, d'Aquino I, Cavaliere G, Paciello O, Mollica MP, Mattace Raso G, Esposito G, Lembo F, Perrino C
Scientific reports 2021 Apr 1;11(1):7404
Scientific reports 2021 Apr 1;11(1):7404
Molecular mechanism mediating enteric bacterial translocation after severe burn: the role of cystic fibrosis transmembrane conductance regulator.
Liu X, Chen Y, You B, Peng Y, Chen Y, Yang Z, Zhang Y, Chen J
Burns & trauma 2020;9:tkaa042
Burns & trauma 2020;9:tkaa042
Expression of R345W-Fibulin-3 Induces Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells.
Zhou M, Weber SR, Zhao Y, Chen H, Barber AJ, Grillo SL, Wills CA, Wang HG, Hulleman JD, Sundstrom JM
Frontiers in cell and developmental biology 2020;8:469
Frontiers in cell and developmental biology 2020;8:469
Optimisation of a Novel Bio-Substrate as a Treatment for Atrophic Age-Related Macular Degeneration.
McCormick R, Pearce I, Kaye S, Haneef A
Frontiers in bioengineering and biotechnology 2020;8:456
Frontiers in bioengineering and biotechnology 2020;8:456
Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development.
Panicker N, Coutman M, Lawlor-O'Neill C, Kahl RGS, Roselli S, Verrills NM
Frontiers in cell and developmental biology 2020;8:358
Frontiers in cell and developmental biology 2020;8:358
Cisplatin-Induced Stria Vascularis Damage Is Associated with Inflammation and Fibrosis.
Zhang N, Cai J, Xu L, Wang H, Liu W
Neural plasticity 2020;2020:8851525
Neural plasticity 2020;2020:8851525
Metformin Protects ARPE-19 Cells from Glyoxal-Induced Oxidative Stress.
Qu S, Zhang C, Liu D, Wu J, Tian H, Lu L, Xu GT, Liu F, Zhang J
Oxidative medicine and cellular longevity 2020;2020:1740943
Oxidative medicine and cellular longevity 2020;2020:1740943
Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability.
Cobo-Calvo A, Ruiz A, Richard C, Blondel S, Cavagna S, Strazielle N, Ghersi-Egea JF, Giraudon P, Marignier R
PloS one 2020;15(9):e0238301
PloS one 2020;15(9):e0238301
Testisin/Prss21 deficiency causes increased vascular permeability and a hemorrhagic phenotype during luteal angiogenesis.
Peroutka RJ, Buzza MS, Mukhopadhyay S, Johnson TA, Driesbaugh KH, Antalis TM
PloS one 2020;15(6):e0234407
PloS one 2020;15(6):e0234407
In vivo and ex vivo assessment of bladder hyper-permeability and using molecular targeted magnetic resonance imaging to detect claudin-2 in a mouse model for interstitial cystitis.
Smith N, Saunders D, Lerner M, Zalles M, Mamedova N, Cheong D, Mohammadi E, Yuan T, Luo Y, Hurst RE, Greenwood-Van Meerveld B, Towner RA
PloS one 2020;15(10):e0239282
PloS one 2020;15(10):e0239282
Isolation of Mouse Cerebral Microvasculature for Molecular and Single-Cell Analysis.
Paraiso HC, Wang X, Kuo PC, Furnas D, Scofield BA, Chang FL, Yen JH, Yu IC
Frontiers in cellular neuroscience 2020;14:84
Frontiers in cellular neuroscience 2020;14:84
DL-3n-Butylphthalide Improves Blood-Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion.
Mamtilahun M, Wei Z, Qin C, Wang Y, Tang Y, Shen FX, Tian HL, Zhang Z, Yang GY
Frontiers in cellular neuroscience 2020;14:610714
Frontiers in cellular neuroscience 2020;14:610714
Specific Frequency Electroacupuncture Stimulation Transiently Enhances the Permeability of the Blood-Brain Barrier and Induces Tight Junction Changes.
Zhang S, Gong P, Zhang J, Mao X, Zhao Y, Wang H, Gan L, Lin X
Frontiers in neuroscience 2020;14:582324
Frontiers in neuroscience 2020;14:582324
Reduced Post-ischemic Brain Injury in Transient Receptor Potential Vanilloid 4 Knockout Mice.
Tanaka K, Matsumoto S, Yamada T, Yamasaki R, Suzuki M, Kido MA, Kira JI
Frontiers in neuroscience 2020;14:453
Frontiers in neuroscience 2020;14:453
Connexin36 localization along axon initial segments in the mammalian CNS.
Thomas D, Senecal JM, Lynn BD, Traub RD, Nagy JI
International journal of physiology, pathophysiology and pharmacology 2020;12(6):153-165
International journal of physiology, pathophysiology and pharmacology 2020;12(6):153-165
Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke.
Yang C, Yang Y, DeMars KM, Rosenberg GA, Candelario-Jalil E
Frontiers in neurology 2020;11:887
Frontiers in neurology 2020;11:887
Endothelial Cell Orientation and Polarity Are Controlled by Shear Stress and VEGF Through Distinct Signaling Pathways.
Vion AC, Perovic T, Petit C, Hollfinger I, Bartels-Klein E, Frampton E, Gordon E, Claesson-Welsh L, Gerhardt H
Frontiers in physiology 2020;11:623769
Frontiers in physiology 2020;11:623769
Astragalus mongholicus Bunge and Panax Notoginseng Formula (A&P) Combined With Bifidobacterium Contribute a Renoprotective Effect in Chronic Kidney Disease Through Inhibiting Macrophage Inflammatory Response in Kidney and Intestine.
Rui-Zhi T, Hui D, Jian-Chun L, Xia Z, Xiao-Jia W, Dan W, Jun-Ming F, Li W
Frontiers in physiology 2020;11:583668
Frontiers in physiology 2020;11:583668
Stachyose Improves the Effects of Berberine on Glucose Metabolism by Regulating Intestinal Microbiota and Short-Chain Fatty Acids in Spontaneous Type 2 Diabetic KKAy Mice.
Cao H, Li C, Lei L, Wang X, Liu S, Liu Q, Huan Y, Sun S, Shen Z
Frontiers in pharmacology 2020;11:578943
Frontiers in pharmacology 2020;11:578943
Retinal Distribution and Extracellular Activity of Granzyme B: A Serine Protease That Degrades Retinal Pigment Epithelial Tight Junctions and Extracellular Matrix Proteins.
Matsubara JA, Tian Y, Cui JZ, Zeglinski MR, Hiroyasu S, Turner CT, Granville DJ
Frontiers in immunology 2020;11:574
Frontiers in immunology 2020;11:574
A Method for Developing Novel 3D Cornea-on-a-Chip Using Primary Murine Corneal Epithelial and Endothelial Cells.
Bai J, Fu H, Bazinet L, Birsner AE, D'Amato RJ
Frontiers in pharmacology 2020;11:453
Frontiers in pharmacology 2020;11:453
Impaired Airway Epithelial Barrier Integrity in Response to Stenotrophomonas maltophilia Proteases, Novel Insights Using Cystic Fibrosis Bronchial Epithelial Cell Secretomics.
Molloy K, Cagney G, Dillon ET, Wynne K, Greene CM, McElvaney NG
Frontiers in immunology 2020;11:198
Frontiers in immunology 2020;11:198
Resveratrol Modulates the Gut Microbiota and Inflammation to Protect Against Diabetic Nephropathy in Mice.
Cai TT, Ye XL, Li RR, Chen H, Wang YY, Yong HJ, Pan ML, Lu W, Tang Y, Miao H, Snijders AM, Mao JH, Liu XY, Lu YB, Ding DF
Frontiers in pharmacology 2020;11:1249
Frontiers in pharmacology 2020;11:1249
AhR activation defends gut barrier integrity against damage occurring in obesity.
Postal BG, Ghezzal S, Aguanno D, André S, Garbin K, Genser L, Brot-Laroche E, Poitou C, Soula H, Leturque A, Clément K, Carrière V
Molecular metabolism 2020 Sep;39:101007
Molecular metabolism 2020 Sep;39:101007
Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction.
Jiang J, Huang K, Xu S, Garcia JGN, Wang C, Cai H
Redox biology 2020 Sep;36:101638
Redox biology 2020 Sep;36:101638
Novel developmental bases for the evolution of hypobranchial muscles in vertebrates.
Kusakabe R, Higuchi S, Tanaka M, Kadota M, Nishimura O, Kuratani S
BMC biology 2020 Sep 9;18(1):120
BMC biology 2020 Sep 9;18(1):120
The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis.
Dowdell AS, Cartwright IM, Goldberg MS, Kostelecky R, Ross T, Welch N, Glover LE, Colgan SP
Molecular biology of the cell 2020 Sep 15;31(20):2249-2258
Molecular biology of the cell 2020 Sep 15;31(20):2249-2258
Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2.
Busnadiego I, Fernbach S, Pohl MO, Karakus U, Huber M, Trkola A, Stertz S, Hale BG
mBio 2020 Sep 10;11(5)
mBio 2020 Sep 10;11(5)
Tanycyte ablation in the arcuate nucleus and median eminence increases obesity susceptibility by increasing body fat content in male mice.
Yoo S, Cha D, Kim S, Jiang L, Cooke P, Adebesin M, Wolfe A, Riddle R, Aja S, Blackshaw S
Glia 2020 Oct;68(10):1987-2000
Glia 2020 Oct;68(10):1987-2000
Experimental design of a culture approach for corneal endothelial cells of New Zealand white rabbit.
Montalvo-Parra MD, Vidal-Paredes IA, Calzada-Rodríguez CE, Cárdenas-Rodríguez IT, Torres-Guerrero GF, Gómez-Elizondo D, López-Martínez M, Zavala J, Valdez-García JE
Heliyon 2020 Oct;6(10):e05178
Heliyon 2020 Oct;6(10):e05178
Effect of ultra‑wide‑band electromagnetic pulses on blood‑brain barrier permeability in rats.
Gao P, Chen Q, Hu J, Lin Y, Lin J, Guo Q, Yue H, Zhou Y, Zeng L, Li J, Ding G, Guo G
Molecular medicine reports 2020 Oct;22(4):2775-2782
Molecular medicine reports 2020 Oct;22(4):2775-2782
RAB6 GTPase regulates mammary secretory function by controlling the activation of STAT5.
Cayre S, Faraldo MM, Bardin S, Miserey-Lenkei S, Deugnier MA, Goud B
Development (Cambridge, England) 2020 Oct 8;147(19)
Development (Cambridge, England) 2020 Oct 8;147(19)
Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing.
Zhou X, Brown BA, Siegel AP, El Masry MS, Zeng X, Song W, Das A, Khandelwal P, Clark A, Singh K, Guda PR, Gorain M, Timsina L, Xuan Y, Jacobson SC, Novotny MV, Roy S, Agarwal M, Lee RJ, Sen CK, Clemmer DE, Ghatak S
ACS nano 2020 Oct 27;14(10):12732-12748
ACS nano 2020 Oct 27;14(10):12732-12748
Increased intestinal permeability and gut dysbiosis in the R6/2 mouse model of Huntington's disease.
Stan TL, Soylu-Kucharz R, Burleigh S, Prykhodko O, Cao L, Franke N, Sjögren M, Haikal C, Hållenius F, Björkqvist M
Scientific reports 2020 Oct 26;10(1):18270
Scientific reports 2020 Oct 26;10(1):18270
Behavioral and neurophysiological taste responses to sweet and salt are diminished in a model of subclinical intestinal inflammation.
Pittman DW, Dong G, Brantly AM, He L, Nelson TS, Kogan S, Powell J, McCluskey LP
Scientific reports 2020 Oct 19;10(1):17611
Scientific reports 2020 Oct 19;10(1):17611
Non-Human Primate Blood-Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model.
Chaves C, Do TM, Cegarra C, Roudières V, Tolou S, Thill G, Rocher C, Didier M, Lesuisse D
Pharmaceutics 2020 Oct 14;12(10)
Pharmaceutics 2020 Oct 14;12(10)
Heterozygous Loss of Yap1 in Mice Causes Progressive Cataracts.
Lu Q, Zhang Y, Kasetti RB, Gaddipati S, Cvm NK, Borchman D, Li Q
Investigative ophthalmology & visual science 2020 Oct 1;61(12):21
Investigative ophthalmology & visual science 2020 Oct 1;61(12):21
MiR-22-3p inhibits fibrotic cataract through inactivation of HDAC6 and increase of α-tubulin acetylation.
Wang X, Wang L, Sun Y, Chen B, Xiong L, Chen J, Huang M, Wu J, Tan X, Zheng Y, Huang S, Liu Y
Cell proliferation 2020 Nov;53(11):e12911
Cell proliferation 2020 Nov;53(11):e12911
Hypertonic saline improves brain edema resulting from traumatic brain injury by suppressing the NF-κB/IL-1β signaling pathway and AQP4.
Zhang H, Liu J, Liu Y, Su C, Fan G, Lu W, Feng L
Experimental and therapeutic medicine 2020 Nov;20(5):71
Experimental and therapeutic medicine 2020 Nov;20(5):71
Quantitative analysis and virulence phenotypes of atypical enteropathogenic Escherichia coli (EPEC) acquired from diarrheal stool samples from a Midwest US hospital.
Carlino MJ, Kralicek SE, Santiago SA, Sitaraman LM, Harrington AT, Hecht GA
Gut microbes 2020 Nov 9;12(1):1-21
Gut microbes 2020 Nov 9;12(1):1-21
Correlations between α-Linolenic Acid-Improved Multitissue Homeostasis and Gut Microbiota in Mice Fed a High-Fat Diet.
Gao X, Chang S, Liu S, Peng L, Xie J, Dong W, Tian Y, Sheng J
mSystems 2020 Nov 3;5(6)
mSystems 2020 Nov 3;5(6)
Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer's disease.
Shi H, Koronyo Y, Fuchs DT, Sheyn J, Wawrowsky K, Lahiri S, Black KL, Koronyo-Hamaoui M
Acta neuropathologica communications 2020 Nov 23;8(1):202
Acta neuropathologica communications 2020 Nov 23;8(1):202
Modulation of NLRP3 Inflammasome Attenuated Inflammatory Response Associated to Diarrhea-Predominant Irritable Bowel Syndrome.
Scuderi SA, Casili G, Lanza M, Filippone A, Paterniti I, Esposito E, Campolo M
Biomedicines 2020 Nov 20;8(11)
Biomedicines 2020 Nov 20;8(11)
Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells.
Ristori E, Cicaloni V, Salvini L, Tinti L, Tinti C, Simons M, Corti F, Donnini S, Ziche M
Cells 2020 Nov 19;9(11)
Cells 2020 Nov 19;9(11)
Cell-Type-Specific Complement Profiling in the ABCA4(-/-) Mouse Model of Stargardt Disease.
Jabri Y, Biber J, Diaz-Lezama N, Grosche A, Pauly D
International journal of molecular sciences 2020 Nov 11;21(22)
International journal of molecular sciences 2020 Nov 11;21(22)
Exosome/microvesicle content is altered in leucine-rich repeat kinase 2 mutant induced pluripotent stem cell-derived neural cells.
Candelario KM, Balaj L, Zheng T, Skog J, Scheffler B, Breakefield X, Schüle B, Steindler DA
The Journal of comparative neurology 2020 May;528(7):1203-1215
The Journal of comparative neurology 2020 May;528(7):1203-1215
A Semiautomated, Phenotypic, In Vitro Scratch Assay for Assessing Retinal Pigment Epithelial Cell Wound Healing.
Storm T, Wilson I, Campbell R, Bolinches-Amorós A, Russell AJ, Davies SG, Barnard AR, MacLaren RE
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2020 May;36(4):257-266
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2020 May;36(4):257-266
Luteolin prevents irinotecan-induced intestinal mucositis in mice through antioxidant and anti-inflammatory properties.
Boeing T, de Souza P, Speca S, Somensi LB, Mariano LNB, Cury BJ, Ferreira Dos Anjos M, Quintão NLM, Dubuqoy L, Desreumax P, da Silva LM, de Andrade SF
British journal of pharmacology 2020 May;177(10):2393-2408
British journal of pharmacology 2020 May;177(10):2393-2408
Preliminary Assessment of the Mucosal Toxicity of Tea Tree (Melaleuca alternifolia) and Rosemary (Rosmarinus officinalis) Essential Oils on Novel Porcine Uterus Models.
Bertocchi M, Rigillo A, Elmi A, Ventrella D, Aniballi C, G Scorpio D, Scozzoli M, Bettini G, Forni M, Bacci ML
International journal of molecular sciences 2020 May 9;21(9)
International journal of molecular sciences 2020 May 9;21(9)
Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies.
Christians A, Weiss AC, Martens H, Klopf MG, Hennies I, Haffner D, Kispert A, Weber RG
Human molecular genetics 2020 May 8;29(7):1192-1204
Human molecular genetics 2020 May 8;29(7):1192-1204
Transcriptomic profiles reveal differences in zinc metabolism, inflammation, and tight junction proteins in duodenum from cholesterol gallstone subjects.
Riveras E, Azocar L, Moyano TC, Ocares M, Molina H, Romero D, Roa JC, Valbuena JR, Gutiérrez RA, Miquel JF
Scientific reports 2020 May 4;10(1):7448
Scientific reports 2020 May 4;10(1):7448
Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease.
Price GW, Chadjichristos CE, Kavvadas P, Tang SCW, Yiu WH, Green CR, Potter JA, Siamantouras E, Squires PE, Hills CE
Cell communication and signaling : CCS 2020 May 25;18(1):79
Cell communication and signaling : CCS 2020 May 25;18(1):79
Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke.
Kang L, Yu H, Yang X, Zhu Y, Bai X, Wang R, Cao Y, Xu H, Luo H, Lu L, Shi MJ, Tian Y, Fan W, Zhao BQ
Nature communications 2020 May 19;11(1):2488
Nature communications 2020 May 19;11(1):2488
Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision.
Salido EM, Ramamurthy V
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 May 13;40(20):4059-4072
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 May 13;40(20):4059-4072
YAP Mediates Hair Cell Regeneration in Balance Organs of Chickens, But LATS Kinases Suppress Its Activity in Mice.
Rudolf MA, Andreeva A, Kozlowski MM, Kim CE, Moskowitz BA, Anaya-Rocha A, Kelley MW, Corwin JT
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 May 13;40(20):3915-3932
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 May 13;40(20):3915-3932
Transporter-Mediated Mitochondrial GSH Depletion Leading to Mitochondrial Dysfunction and Rescue with αB Crystallin Peptide in RPE Cells.
Sreekumar PG, Wang M, Spee C, Sadda SR, Kannan R
Antioxidants (Basel, Switzerland) 2020 May 12;9(5)
Antioxidants (Basel, Switzerland) 2020 May 12;9(5)
TGF-β1 relieves epithelial-mesenchymal transition reduction in hypospadias induced by DEHP in rats.
Zhou Y, Huang F, Liu Y, Li D, Zhou Y, Shen L, Long C, Liu X, Wei G
Pediatric research 2020 Mar;87(4):639-646
Pediatric research 2020 Mar;87(4):639-646
Engineering the mode of morphogenetic signal presentation to promote branching from salivary gland spheroids in 3D hydrogels.
Samuel RZ, Lei P, Nam K, Baker OJ, Andreadis ST
Acta biomaterialia 2020 Mar 15;105:121-130
Acta biomaterialia 2020 Mar 15;105:121-130
Enhancement of aberrantly modified integrin‑mediated cell motility in multicellular tumor spheroids.
Kim B, Im NR, Yang TD, Kim J, Jung KY, Kim TH, Baek SK
International journal of oncology 2020 Jun;56(6):1490-1498
International journal of oncology 2020 Jun;56(6):1490-1498
Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease.
Giacomelli E, Meraviglia V, Campostrini G, Cochrane A, Cao X, van Helden RWJ, Krotenberg Garcia A, Mircea M, Kostidis S, Davis RP, van Meer BJ, Jost CR, Koster AJ, Mei H, Míguez DG, Mulder AA, Ledesma-Terrón M, Pompilio G, Sala L, Salvatori DCF, Slieker RC, Sommariva E, de Vries AAF, Giera M, Semrau S, Tertoolen LGJ, Orlova VV, Bellin M, Mummery CL
Cell stem cell 2020 Jun 4;26(6):862-879.e11
Cell stem cell 2020 Jun 4;26(6):862-879.e11
Brain tight junction protein expression in sepsis in an autopsy series.
Erikson K, Tuominen H, Vakkala M, Liisanantti JH, Karttunen T, Syrjälä H, Ala-Kokko TI
Critical care (London, England) 2020 Jun 29;24(1):385
Critical care (London, England) 2020 Jun 29;24(1):385
RBFOX1 Regulates the Permeability of the Blood-Tumor Barrier via the LINC00673/MAFF Pathway.
Shen S, Yang C, Liu X, Zheng J, Liu Y, Liu L, Ma J, Ma T, An P, Lin Y, Cai H, Wang D, Li Z, Zhao L, Xue Y
Molecular therapy oncolytics 2020 Jun 26;17:138-152
Molecular therapy oncolytics 2020 Jun 26;17:138-152
Development of a human in vitro blood-brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance.
Deligne C, Hachani J, Duban-Deweer S, Meignan S, Leblond P, Carcaboso AM, Sano Y, Shimizu F, Kanda T, Gosselet F, Dehouck MP, Mysiorek C
Fluids and barriers of the CNS 2020 Jun 2;17(1):37
Fluids and barriers of the CNS 2020 Jun 2;17(1):37
Challenging human somatic testicular cell reassembly by protein kinase inhibition -setting up a functional in vitro test system.
Mincheva M, Wistuba J, Brenker C, Schlatt S
Scientific reports 2020 Jun 2;10(1):8935
Scientific reports 2020 Jun 2;10(1):8935
Bile Acid Sequestrant, Sevelamer Ameliorates Hepatic Fibrosis with Reduced Overload of Endogenous Lipopolysaccharide in Experimental Nonalcoholic Steatohepatitis.
Tsuji Y, Kaji K, Kitade M, Kaya D, Kitagawa K, Ozutsumi T, Fujinaga Y, Takaya H, Kawaratani H, Namisaki T, Moriya K, Akahane T, Yoshiji H
Microorganisms 2020 Jun 19;8(6)
Microorganisms 2020 Jun 19;8(6)
Transcriptome-Wide Analysis of CXCR5 Deficient Retinal Pigment Epithelial (RPE) Cells Reveals Molecular Signatures of RPE Homeostasis.
Saddala MS, Lennikov A, Mukwaya A, Huang H
Biomedicines 2020 Jun 1;8(6)
Biomedicines 2020 Jun 1;8(6)
Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation.
Iwaki A, Moriwaki K, Sobajima T, Taniguchi M, Yoshimura SI, Kunii M, Kanda S, Kamada Y, Miyoshi E, Harada A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jul;34(7):9450-9465
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jul;34(7):9450-9465
Significant Changes in Trans-Epithelial Barrier Proteins of Adenoid Tissue with Atopic Status in Children.
Yılmaz Ö, Şimşek Y, İnan S, Buga Ö, Eskiizmir G, Pınar E, Kanık E, Yüksel H
Turkish thoracic journal 2020 Jul;21(4):242-247
Turkish thoracic journal 2020 Jul;21(4):242-247
Snail induces epithelial cell extrusion by regulating RhoA contractile signalling and cell-matrix adhesion.
Wee K, Hediyeh-Zadeh S, Duszyc K, Verma S, N Nanavati B, Khare S, Varma A, Daly RJ, Yap AS, Davis MJ, Budnar S
Journal of cell science 2020 Jul 6;133(13)
Journal of cell science 2020 Jul 6;133(13)
In-Depth Study of Transmembrane Mucins in Association with Intestinal Barrier Dysfunction During the Course of T Cell Transfer and DSS-Induced Colitis.
Breugelmans T, Van Spaendonk H, De Man JG, De Schepper HU, Jauregui-Amezaga A, Macken E, Lindén SK, Pintelon I, Timmermans JP, De Winter BY, Smet A
Journal of Crohn's & colitis 2020 Jul 30;14(7):974-994
Journal of Crohn's & colitis 2020 Jul 30;14(7):974-994
Placental gene editing via trophectoderm-specific Tat-Cre/loxP recombination.
Ozguldez HO, Fan R, Bedzhov I
Development (Cambridge, England) 2020 Jul 3;147(13)
Development (Cambridge, England) 2020 Jul 3;147(13)
Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis.
Dong X, Kwan KM
Molecular brain 2020 Jul 23;13(1):104
Molecular brain 2020 Jul 23;13(1):104
MCH Neurons Regulate Permeability of the Median Eminence Barrier.
Jiang H, Gallet S, Klemm P, Scholl P, Folz-Donahue K, Altmüller J, Alber J, Heilinger C, Kukat C, Loyens A, Müller-Fielitz H, Sundaram S, Schwaninger M, Prevot V, Brüning JC
Neuron 2020 Jul 22;107(2):306-319.e9
Neuron 2020 Jul 22;107(2):306-319.e9
Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation.
Alladin A, Chaible L, Garcia Del Valle L, Sabine R, Loeschinger M, Wachsmuth M, Hériché JK, Tischer C, Jechlinger M
eLife 2020 Jul 21;9
eLife 2020 Jul 21;9
Intestinal Enteroid Culture for Human Astroviruses.
Owusu IA, Mirabelli C, Kolawole AO
Bio-protocol 2020 Jul 20;10(14):e3687
Bio-protocol 2020 Jul 20;10(14):e3687
Regulatory Effect of Lactobacillus brevis Bmb6 on Gut Barrier Functions in Experimental Colitis.
Shin MY, Yong CC, Oh S
Foods (Basel, Switzerland) 2020 Jul 2;9(7)
Foods (Basel, Switzerland) 2020 Jul 2;9(7)
IL-1β strengthens the physical barrier in gingival epithelial cells.
Stolte KN, Pelz C, Yapto CV, Raguse JD, Dommisch H, Danker K
Tissue barriers 2020 Jul 2;8(3):1804249
Tissue barriers 2020 Jul 2;8(3):1804249
Topical Delivery of Curcumin by Choline-Calix[4]arene-Based Nanohydrogel Improves Its Therapeutic Effect on a Psoriasis Mouse Model.
Filippone A, Consoli GML, Granata G, Casili G, Lanza M, Ardizzone A, Cuzzocrea S, Esposito E, Paterniti I
International journal of molecular sciences 2020 Jul 17;21(14)
International journal of molecular sciences 2020 Jul 17;21(14)
Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation.
Kristensen M, Kucharz K, Felipe Alves Fernandes E, Strømgaard K, Schallburg Nielsen M, Cederberg Helms HC, Bach A, Ulrikkaholm Tofte-Hansen M, Irene Aldana Garcia B, Lauritzen M, Brodin B
Pharmaceutics 2020 Jul 14;12(7)
Pharmaceutics 2020 Jul 14;12(7)
Mechano-modulatory synthetic niches for liver organoid derivation.
Sorrentino G, Rezakhani S, Yildiz E, Nuciforo S, Heim MH, Lutolf MP, Schoonjans K
Nature communications 2020 Jul 10;11(1):3416
Nature communications 2020 Jul 10;11(1):3416
Differential expression of cell-cell junction proteins in the testis, epididymis, and ductus deferens of domestic turkeys (Meleagris gallopavo) with white and yellow semen.
Pardyak L, Kaminska A, Brzoskwinia M, Hejmej A, Kotula-Balak M, Jankowski J, Ciereszko A, Bilinska B
Poultry science 2020 Jan;99(1):555-566
Poultry science 2020 Jan;99(1):555-566
Expression of Neurotrophic Factors, Tight Junction Proteins, and Cytokines According to the Irritable Bowel Syndrome Subtype and Sex.
Lee JY, Kim N, Park JH, Nam RH, Lee SM, Song CH, Kim G, Na HY, Choi YJ, Kim JJ, Lee DH
Journal of neurogastroenterology and motility 2020 Jan 30;26(1):106-116
Journal of neurogastroenterology and motility 2020 Jan 30;26(1):106-116
The tight junction protein TJP1 regulates the feeding-modulated hepatic circadian clock.
Liu Y, Zhang Y, Li T, Han J, Wang Y
Nature communications 2020 Jan 30;11(1):589
Nature communications 2020 Jan 30;11(1):589
Epithelial-specific isoforms of protein 4.1R promote adherens junction assembly in maturing epithelia.
Huang SC, Liang JY, Vu LV, Yu FH, Ou AC, Ou JP, Zhang HS, Burnett KM, Benz EJ Jr
The Journal of biological chemistry 2020 Jan 3;295(1):191-211
The Journal of biological chemistry 2020 Jan 3;295(1):191-211
Jedi-1 deficiency increases sensory neuron excitability through a non-cell autonomous mechanism.
Trevisan AJ, Bauer MB, Brindley RL, Currie KPM, Carter BD
Scientific reports 2020 Jan 28;10(1):1300
Scientific reports 2020 Jan 28;10(1):1300
The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction.
Sayoc-Becerra A, Krishnan M, Fan S, Jimenez J, Hernandez R, Gibson K, Preciado R, Butt G, McCole DF
Inflammatory bowel diseases 2020 Feb 11;26(3):407-422
Inflammatory bowel diseases 2020 Feb 11;26(3):407-422
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.
Salahudeen AA, Choi SS, Rustagi A, Zhu J, van Unen V, de la O SM, Flynn RA, Margalef-Català M, Santos AJM, Ju J, Batish A, Usui T, Zheng GXY, Edwards CE, Wagar LE, Luca V, Anchang B, Nagendran M, Nguyen K, Hart DJ, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Harbury PB, Glenn JS, Garcia KC, Davis MM, Baric RS, Sabatti C, Amieva MR, Blish CA, Desai TJ, Kuo CJ
Nature 2020 Dec;588(7839):670-675
Nature 2020 Dec;588(7839):670-675
An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes.
Gijzen L, Marescotti D, Raineri E, Nicolas A, Lanz HL, Guerrera D, van Vught R, Joore J, Vulto P, Peitsch MC, Hoeng J, Lo Sasso G, Kurek D
SLAS technology 2020 Dec;25(6):585-597
SLAS technology 2020 Dec;25(6):585-597
Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers.
Cray P, Sheahan BJ, Cortes JE, Dekaney CM
Scientific reports 2020 Dec 8;10(1):21486
Scientific reports 2020 Dec 8;10(1):21486
Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation.
Cui J, Shipley FB, Shannon ML, Alturkistani O, Dani N, Webb MD, Sugden AU, Andermann ML, Lehtinen MK
Developmental cell 2020 Dec 7;55(5):617-628.e6
Developmental cell 2020 Dec 7;55(5):617-628.e6
Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis.
Ram AK, Vairappan B, Srinivas BH
World journal of gastroenterology 2020 Dec 7;26(45):7131-7152
World journal of gastroenterology 2020 Dec 7;26(45):7131-7152
Vascular Tumor Recapitulated in Endothelial Cells from hiPSCs Engineered to Express the SERPINE1-FOSB Translocation.
van IJzendoorn DGP, Salvatori DCF, Cao X, van den Hil F, Briaire-de Bruijn IH, de Jong D, Mei H, Mummery CL, Szuhai K, Bovée JVMG, Orlova VV
Cell reports. Medicine 2020 Dec 22;1(9):100153
Cell reports. Medicine 2020 Dec 22;1(9):100153
Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NFκB activation.
Lennikov A, Mukwaya A, Fan L, Saddala MS, De Falco S, Huang H
Experimental cell research 2020 Dec 15;397(2):112347
Experimental cell research 2020 Dec 15;397(2):112347
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion.
Zhang X, Wu J, Liu Q, Li X, Li S, Chen J, Hong Z, Wu X, Zhao Y, Ren J
Cell death & disease 2020 Dec 11;11(12):1050
Cell death & disease 2020 Dec 11;11(12):1050
Systemic Inflammation by Collagen-Induced Arthritis Affects the Progression of Age-Related Macular Degeneration Differently in Two Mouse Models of the Disease.
Schnabolk G, Obert E, Banda NK, Rohrer B
Investigative ophthalmology & visual science 2020 Dec 1;61(14):11
Investigative ophthalmology & visual science 2020 Dec 1;61(14):11
Mechanisms of stretch-mediated skin expansion at single-cell resolution.
Aragona M, Sifrim A, Malfait M, Song Y, Van Herck J, Dekoninck S, Gargouri S, Lapouge G, Swedlund B, Dubois C, Baatsen P, Vints K, Han S, Tissir F, Voet T, Simons BD, Blanpain C
Nature 2020 Aug;584(7820):268-273
Nature 2020 Aug;584(7820):268-273
Lnc00462717 regulates the permeability of the blood-brain tumor barrier through interaction with PTBP1 to inhibit the miR-186-5p/Occludin signaling pathway.
Zhang C, Zhang X, Wang J, Di F, Xue Y, Lin X, Zhang Y, Zhang H, Zhang Z, Gu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Aug;34(8):9941-9958
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Aug;34(8):9941-9958
Sigma-1 receptor activation-induced glycolytic ATP production and endothelial barrier enhancement.
Motawe ZY, Farsaei F, Abdelmaboud SS, Cuevas J, Breslin JW
Microcirculation (New York, N.Y. : 1994) 2020 Aug;27(6):e12620
Microcirculation (New York, N.Y. : 1994) 2020 Aug;27(6):e12620
HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis.
Devraj G, Guérit S, Seele J, Spitzer D, Macas J, Khel MI, Heidemann R, Braczynski AK, Ballhorn W, Günther S, Ogunshola OO, Mittelbronn M, Ködel U, Monoranu CM, Plate KH, Hammerschmidt S, Nau R, Devraj K, Kempf VAJ
Acta neuropathologica 2020 Aug;140(2):183-208
Acta neuropathologica 2020 Aug;140(2):183-208
Human iPSC Modeling Reveals Mutation-Specific Responses to Gene Therapy in a Genotypically Diverse Dominant Maculopathy.
Sinha D, Steyer B, Shahi PK, Mueller KP, Valiauga R, Edwards KL, Bacig C, Steltzer SS, Srinivasan S, Abdeen A, Cory E, Periyasamy V, Siahpirani AF, Stone EM, Tucker BA, Roy S, Pattnaik BR, Saha K, Gamm DM
American journal of human genetics 2020 Aug 6;107(2):278-292
American journal of human genetics 2020 Aug 6;107(2):278-292
Neutrophil Extracellular Traps Impair Intestinal Barrier Function during Experimental Colitis.
Lin EY, Lai HJ, Cheng YK, Leong KQ, Cheng LC, Chou YC, Peng YC, Hsu YH, Chiang HS
Biomedicines 2020 Aug 5;8(8)
Biomedicines 2020 Aug 5;8(8)
Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier.
Clé M, Desmetz C, Barthelemy J, Martin MF, Constant O, Maarifi G, Foulongne V, Bolloré K, Glasson Y, De Bock F, Blaquiere M, Dehouck L, Pirot N, Tuaillon E, Nisole S, Najioullah F, Van de Perre P, Cabié A, Marchi N, Gosselet F, Simonin Y, Salinas S
mBio 2020 Aug 4;11(4)
mBio 2020 Aug 4;11(4)
The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples.
Duarte Lobo D, Nobre RJ, Oliveira Miranda C, Pereira D, Castelhano J, Sereno J, Koeppen A, Castelo-Branco M, Pereira de Almeida L
Acta neuropathologica communications 2020 Aug 31;8(1):152
Acta neuropathologica communications 2020 Aug 31;8(1):152
The spleen mediates chronic sleep restriction-mediated enhancement of LPS-induced neuroinflammation, cognitive deficits, and anxiety-like behavior.
Xu D, Zhang Y, Xie B, Yao H, Yuan Y, Yuan S, Zhang J
Aging 2020 Aug 3;12(15):15446-15461
Aging 2020 Aug 3;12(15):15446-15461
Maltodextrin-induced intestinal injury in a neonatal mouse model.
Singh P, Sanchez-Fernandez LL, Ramiro-Cortijo D, Ochoa-Allemant P, Perides G, Liu Y, Medina-Morales E, Yakah W, Freedman SD, Martin CR
Disease models & mechanisms 2020 Aug 27;13(8)
Disease models & mechanisms 2020 Aug 27;13(8)
Axl Deficiency Promotes the Neuroinvasion of Japanese Encephalitis Virus by Enhancing IL-1α Production from Pyroptotic Macrophages.
Wang ZY, Zhen ZD, Fan DY, Qin CF, Han DS, Zhou HN, Wang PG, An J
Journal of virology 2020 Aug 17;94(17)
Journal of virology 2020 Aug 17;94(17)
Transition of podosomes into zipper-like structures in macrophage-derived multinucleated giant cells.
Balabiyev A, Podolnikova NP, Mursalimov A, Lowry D, Newbern JM, Roberson RW, Ugarova TP
Molecular biology of the cell 2020 Aug 15;31(18):2002-2020
Molecular biology of the cell 2020 Aug 15;31(18):2002-2020
Eugenol attenuates inflammatory response and enhances barrier function during lipopolysaccharide-induced inflammation in the porcine intestinal epithelial cells.
Hui Q, Ammeter E, Liu S, Yang R, Lu P, Lahaye L, Yang C
Journal of animal science 2020 Aug 1;98(8)
Journal of animal science 2020 Aug 1;98(8)
Pioglitazone Attenuates Experimental Colitis-Associated Hyperalgesia through Improving the Intestinal Barrier Dysfunction.
Huang Y, Wang C, Tian X, Mao Y, Hou B, Sun Y, Gu X, Ma Z
Inflammation 2020 Apr;43(2):568-578
Inflammation 2020 Apr;43(2):568-578
Role of monocarboxylate transporters in regulating metabolic homeostasis in the outer retina: Insight gained from cell-specific Bsg deletion.
Han JYS, Kinoshita J, Bisetto S, Bell BA, Nowak RA, Peachey NS, Philp NJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5401-5419
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5401-5419
Prevention of excessive exercise-induced adverse effects in rats with Bacillus subtilis BSB3.
Ducray HAG, Globa L, Pustovyy O, Roberts MD, Rudisill M, Vodyanoy V, Sorokulova I
Journal of applied microbiology 2020 Apr;128(4):1163-1178
Journal of applied microbiology 2020 Apr;128(4):1163-1178
Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity.
Sasaki K, Kojitani N, Hirose H, Yoshihama Y, Suzuki H, Shimada M, Takayanagi A, Yamashita A, Nakaya MA, Hirano H, Takahashi H, Ohno S
Cell reports 2020 Apr 7;31(1):107407
Cell reports 2020 Apr 7;31(1):107407
KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke.
Zhang X, Wang L, Han Z, Dong J, Pang D, Fu Y, Li L
Journal of neuroinflammation 2020 Apr 7;17(1):107
Journal of neuroinflammation 2020 Apr 7;17(1):107
Expression of Tight Junction Proteins According to Functional Dyspepsia Subtype and Sex.
Lee JY, Kim N, Choi YJ, Park JH, Ashktorab H, Smoot DT, Lee DH
Journal of neurogastroenterology and motility 2020 Apr 30;26(2):248-258
Journal of neurogastroenterology and motility 2020 Apr 30;26(2):248-258
Use of EpiAlveolar Lung Model to Predict Fibrotic Potential of Multiwalled Carbon Nanotubes.
Barosova H, Maione AG, Septiadi D, Sharma M, Haeni L, Balog S, O'Connell O, Jackson GR, Brown D, Clippinger AJ, Hayden P, Petri-Fink A, Stone V, Rothen-Rutishauser B
ACS nano 2020 Apr 28;14(4):3941-3956
ACS nano 2020 Apr 28;14(4):3941-3956
Isolation and initial propagation of guinea pig adenovirus (GPAdV) in Cavia porcellus cell lines.
Kajon AE, Li X, Gonzalez G, Core S, Hofmann-Sieber H, Leng S
F1000Research 2019;8:1597
F1000Research 2019;8:1597
Occludin knockdown is not sufficient to induce transepithelial macromolecule passage.
Richter JF, Hildner M, Schmauder R, Turner JR, Schumann M, Reiche J
Tissue barriers 2019;7(2):1612661
Tissue barriers 2019;7(2):1612661
Arresting proliferation improves the cell identity of corneal endothelial cells in the New Zealand rabbit.
Rodríguez-Barrientos CA, Trevino V, Zavala J, Montalvo-Parra MD, Guerrero-Ramírez GI, Aguirre-Gamboa R, Valdez-García JE
Molecular vision 2019;25:745-755
Molecular vision 2019;25:745-755
Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish.
Maerz LD, Burkhalter MD, Schilpp C, Wittekindt OH, Frick M, Philipp M
Communications biology 2019;2:31
Communications biology 2019;2:31
Transfusion of Resting Platelets Reduces Brain Hemorrhage After Intracerebral Hemorrhage and tPA-Induced Hemorrhage After Cerebral Ischemia.
Luo H, Wei L, Lu L, Kang L, Cao Y, Yang X, Bai X, Fan W, Zhao BQ
Frontiers in neuroscience 2019;13:338
Frontiers in neuroscience 2019;13:338
Influence of a Hyperglycemic Microenvironment on a Diabetic Versus Healthy Rat Vascular Endothelium Reveals Distinguishable Mechanistic and Phenotypic Responses.
Haspula D, Vallejos AK, Moore TM, Tomar N, Dash RK, Hoffmann BR
Frontiers in physiology 2019;10:558
Frontiers in physiology 2019;10:558
Sexual Dimorphism in Immune Development and in Response to Nutritional Intervention in Neonatal Piglets.
Christoforidou Z, Mora Ortiz M, Poveda C, Abbas M, Walton G, Bailey M, Lewis MC
Frontiers in immunology 2019;10:2705
Frontiers in immunology 2019;10:2705
Hypertonic saline downregulates endothelial cell-derived VEGF expression and reduces blood-brain barrier permeability induced by cerebral ischaemia via the VEGFR2/eNOS pathway.
Wang Q, Deng Y, Huang L, Zeng W, Chen S, Lv B, Jiang W, Han Y, Ding H, Wen M, Zeng H
International journal of molecular medicine 2019 Sep;44(3):1078-1090
International journal of molecular medicine 2019 Sep;44(3):1078-1090
Syncytiotrophoblast of Placentae from Women with Zika Virus Infection Has Altered Tight Junction Protein Expression and Increased Paracellular Permeability.
Miranda J, Martín-Tapia D, Valdespino-Vázquez Y, Alarcón L, Espejel-Nuñez A, Guzmán-Huerta M, Muñoz-Medina JE, Shibayama M, Chávez-Munguía B, Estrada-Gutiérrez G, Lievano S, Ludert JE, González-Mariscal L
Cells 2019 Sep 29;8(10)
Cells 2019 Sep 29;8(10)
Attenuated Amiloride-Sensitive Current and Augmented Calcium-Activated Chloride Current in Marsh Rice Rat (Oryzomys palustris) Airways.
Kuan SP, Liao YJ, Davis KM, Messer JG, Zubcevic J, Aguirre JI, Reznikov LR
iScience 2019 Sep 27;19:737-748
iScience 2019 Sep 27;19:737-748
Pepsin Triggers Neutrophil Migration Across Acid Damaged Lung Epithelium.
Hurley BP, Jugo RH, Snow RF, Samuels TL, Yonker LM, Mou H, Johnston N, Rosen R
Scientific reports 2019 Sep 24;9(1):13778
Scientific reports 2019 Sep 24;9(1):13778
Expression of a CARD Slows the Retinal Degeneration of a Geographic Atrophy Mouse Model.
Young BM, Jones K, Massengill MT, Walsh E, Li H, Lewin AS, Ildefonso CJ
Molecular therapy. Methods & clinical development 2019 Sep 13;14:113-125
Molecular therapy. Methods & clinical development 2019 Sep 13;14:113-125
Claudin-12 is not required for blood-brain barrier tight junction function.
Castro Dias M, Coisne C, Baden P, Enzmann G, Garrett L, Becker L, Hölter SM, German Mouse Clinic Consortium, Hrabě de Angelis M, Deutsch U, Engelhardt B
Fluids and barriers of the CNS 2019 Sep 12;16(1):30
Fluids and barriers of the CNS 2019 Sep 12;16(1):30
CRISPR-Cas9-mediated therapeutic editing of Rpe65 ameliorates the disease phenotypes in a mouse model of Leber congenital amaurosis.
Jo DH, Song DW, Cho CS, Kim UG, Lee KJ, Lee K, Park SW, Kim D, Kim JH, Kim JS, Kim S, Kim JH, Lee JM
Science advances 2019 Oct;5(10):eaax1210
Science advances 2019 Oct;5(10):eaax1210
The microstructure of laminin-111 compensates for dystroglycan loss in mammary epithelial cells in downstream expression of milk proteins.
Kent AJ, Mayer N, Inman JL, Hochman-Mendez C, Bissell MJ, Robertson C
Biomaterials 2019 Oct;218:119337
Biomaterials 2019 Oct;218:119337
Tunicamycin-induced photoreceptor atrophy precedes degeneration of retinal capillaries with minimal effects on retinal ganglion and pigment epithelium cells.
Wang S, Liu Y, Tan JW, Hu T, Zhang HF, Sorenson CM, Smith JA, Sheibani N
Experimental eye research 2019 Oct;187:107756
Experimental eye research 2019 Oct;187:107756
Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke.
Wen SW, Shim R, Ho L, Wanrooy BJ, Srikhanta YN, Prame Kumar K, Nicholls AJ, Shen SJ, Sepehrizadeh T, de Veer M, Srikanth VK, Ma H, Phan TG, Lyras D, Wong CHY
Aging cell 2019 Oct;18(5):e12980
Aging cell 2019 Oct;18(5):e12980
Effects of Claudin-1 on the Action of Clostridium perfringens Enterotoxin in Caco-2 Cells.
Mehdizadeh Gohari I, Li J, Navarro M, Uzal F, McClane B
Toxins 2019 Oct 9;11(10)
Toxins 2019 Oct 9;11(10)
Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity.
Otani T, Nguyen TP, Tokuda S, Sugihara K, Sugawara T, Furuse K, Miura T, Ebnet K, Furuse M
The Journal of cell biology 2019 Oct 7;218(10):3372-3396
The Journal of cell biology 2019 Oct 7;218(10):3372-3396
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures.
Li R, Zhong C, Yu Y, Liu H, Sakurai M, Yu L, Min Z, Shi L, Wei Y, Takahashi Y, Liao HK, Qiao J, Deng H, Nuñez-Delicado E, Rodriguez Esteban C, Wu J, Izpisua Belmonte JC
Cell 2019 Oct 17;179(3):687-702.e18
Cell 2019 Oct 17;179(3):687-702.e18
Changes in brain kynurenine levels via gut microbiota and gut-barrier disruption induced by chronic ethanol exposure in mice.
Giménez-Gómez P, Pérez-Hernández M, O'Shea E, Caso JR, Martín-Hernandez D, Cervera LA, Centelles MLG, Gutiérrez-Lopez MD, Colado MI
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12900-12914
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12900-12914
Characterization of the polarized endothelial secretome.
Wei H, Sundararaman A, Dickson E, Rennie-Campbell L, Cross E, Heesom KJ, Mellor H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12277-12287
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12277-12287
In vitro and in vivo effects of a mycotoxin, deoxynivalenol, and a trace metal, cadmium, alone or in a mixture on the intestinal barrier.
Luo S, Terciolo C, Bracarense APFL, Payros D, Pinton P, Oswald IP
Environment international 2019 Nov;132:105082
Environment international 2019 Nov;132:105082
A Simulated Microgravity Environment Causes a Sustained Defect in Epithelial Barrier Function.
Alvarez R, Stork CA, Sayoc-Becerra A, Marchelletta RR, Prisk GK, McCole DF
Scientific reports 2019 Nov 26;9(1):17531
Scientific reports 2019 Nov 26;9(1):17531
High-fat diet-mediated dysbiosis exacerbates NSAID-induced small intestinal damage through the induction of interleukin-17A.
Sugimura N, Otani K, Watanabe T, Nakatsu G, Shimada S, Fujimoto K, Nadatani Y, Hosomi S, Tanaka F, Kamata N, Taira K, Nagami Y, Tanigawa T, Uematsu S, Fujiwara Y
Scientific reports 2019 Nov 14;9(1):16796
Scientific reports 2019 Nov 14;9(1):16796
A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes.
Madigan VJ, Tyson TO, Yuziuk JA, Pillai M, Moller-Tank S, Asokan A
Journal of virology 2019 Nov 1;93(21)
Journal of virology 2019 Nov 1;93(21)
Tracking adiponectin biodistribution via fluorescence molecular tomography indicates increased vascular permeability after streptozotocin-induced diabetes.
Yoon N, Dadson K, Dang T, Chu T, Noskovicova N, Hinz B, Raignault A, Thorin E, Kim S, Jeon JS, Jonkman J, McKee TD, Grant J, Peterson JD, Kelly SP, Sweeney G
American journal of physiology. Endocrinology and metabolism 2019 Nov 1;317(5):E760-E772
American journal of physiology. Endocrinology and metabolism 2019 Nov 1;317(5):E760-E772
HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice.
Zhao Q, Zhang F, Yu Z, Guo S, Liu N, Jiang Y, Lo EH, Xu Y, Wang X
Journal of neuroinflammation 2019 May 17;16(1):103
Journal of neuroinflammation 2019 May 17;16(1):103
Targeting the HIV-infected brain to improve ischemic stroke outcome.
Bertrand L, Méroth F, Tournebize M, Leda AR, Sun E, Toborek M
Nature communications 2019 May 1;10(1):2009
Nature communications 2019 May 1;10(1):2009
Vascular regeneration in adult mouse cochlea stimulated by VEGF-A(165) and driven by NG2-derived cells ex vivo.
Wang X, Zhang J, Li G, Sai N, Han J, Hou Z, Kachelmeier A, Shi X
Hearing research 2019 Jun;377:179-188
Hearing research 2019 Jun;377:179-188
Polarized AAVR expression determines infectivity by AAV gene therapy vectors.
Hamilton BA, Li X, Pezzulo AA, Abou Alaiwa MH, Zabner J
Gene therapy 2019 Jun;26(6):240-249
Gene therapy 2019 Jun;26(6):240-249
Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration.
Rosales MAB, Shu DY, Iacovelli J, Saint-Geniez M
Life science alliance 2019 Jun;2(3)
Life science alliance 2019 Jun;2(3)
A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor.
Florian S, Iwamoto Y, Coughlin M, Weissleder R, Mitchison TJ
Proceedings of the National Academy of Sciences of the United States of America 2019 Jun 4;116(23):11444-11453
Proceedings of the National Academy of Sciences of the United States of America 2019 Jun 4;116(23):11444-11453
gH625-liposomes as tool for pituitary adenylate cyclase-activating polypeptide brain delivery.
Iachetta G, Falanga A, Molino Y, Masse M, Jabès F, Mechioukhi Y, Laforgia V, Khrestchatisky M, Galdiero S, Valiante S
Scientific reports 2019 Jun 24;9(1):9183
Scientific reports 2019 Jun 24;9(1):9183
Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture.
Love HD, Ao M, Jorgensen S, Swearingen L, Ferrell N, Evans R, Gewin L, Harris RC, Zent R, Roy S, Fissell WH
Tissue engineering. Part A 2019 Jul;25(13-14):1013-1022
Tissue engineering. Part A 2019 Jul;25(13-14):1013-1022
Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: An in vitro study.
Li LX, Wu SW, Yan M, Lian QQ, Ge RS, Cheng CY
Asian journal of andrology 2019 Jul-Aug;21(4):365-375
Asian journal of andrology 2019 Jul-Aug;21(4):365-375
Effect of Manitoba-Grown Red-Osier Dogwood Extracts on Recovering Caco-2 Cells from H(2)O(2)-Induced Oxidative Damage.
Yang R, Hui Q, Jiang Q, Liu S, Zhang H, Wu J, Lin F, O K, Yang C
Antioxidants (Basel, Switzerland) 2019 Jul 28;8(8)
Antioxidants (Basel, Switzerland) 2019 Jul 28;8(8)
The Y227N mutation affects bestrophin-1 protein stability and impairs sperm function in a mouse model of Best vitelliform macular dystrophy.
Milenkovic A, Schmied D, Tanimoto N, Seeliger MW, Sparrow JR, Weber BHF
Biology open 2019 Jul 2;8(7)
Biology open 2019 Jul 2;8(7)
Pretreatment with probiotic Enterococcus faecium NCIMB 11181 ameliorates necrotic enteritis-induced intestinal barrier injury in broiler chickens.
Wu Y, Zhen W, Geng Y, Wang Z, Guo Y
Scientific reports 2019 Jul 16;9(1):10256
Scientific reports 2019 Jul 16;9(1):10256
mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model.
Yan M, Li L, Mao B, Li H, Li SYT, Mruk D, Silvestrini B, Lian Q, Ge R, Cheng CY
American journal of physiology. Endocrinology and metabolism 2019 Jul 1;317(1):E121-E138
American journal of physiology. Endocrinology and metabolism 2019 Jul 1;317(1):E121-E138
Derivation of Mouse Haploid Trophoblast Stem Cells.
Cui T, Jiang L, Li T, Teng F, Feng G, Wang X, He Z, Guo L, Xu K, Mao Y, Wang L, Yuan X, Wang L, Li W, Zhou Q
Cell reports 2019 Jan 8;26(2):407-414.e5
Cell reports 2019 Jan 8;26(2):407-414.e5
Human Brain Endothelial CXCR2 is Inflammation-Inducible and Mediates CXCL5- and CXCL8-Triggered Paraendothelial Barrier Breakdown.
Haarmann A, Schuhmann MK, Silwedel C, Monoranu CM, Stoll G, Buttmann M
International journal of molecular sciences 2019 Jan 30;20(3)
International journal of molecular sciences 2019 Jan 30;20(3)
Ferulic acid protects against heat stress-induced intestinal epithelial barrier dysfunction in IEC-6 cells via the PI3K/Akt-mediated Nrf2/HO-1 signaling pathway.
He S, Guo Y, Zhao J, Xu X, Song J, Wang N, Liu Q
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2019 Jan 1;35(1):112-121
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2019 Jan 1;35(1):112-121
Protease-activated receptor-1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy.
Waasdorp M, de Rooij DM, Florquin S, Duitman J, Spek CA
Journal of cellular and molecular medicine 2019 Feb;23(2):1268-1279
Journal of cellular and molecular medicine 2019 Feb;23(2):1268-1279
p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects.
Little JN, Dwyer ND
Human molecular genetics 2019 Feb 1;28(3):434-447
Human molecular genetics 2019 Feb 1;28(3):434-447
Decreased ω-6:ω-3 PUFA ratio attenuates ethanol-induced alterations in intestinal homeostasis, microbiota, and liver injury.
Warner DR, Warner JB, Hardesty JE, Song YL, King TN, Kang JX, Chen CY, Xie S, Yuan F, Prodhan MAI, Ma X, Zhang X, Rouchka EC, Maddipati KR, Whitlock J, Li EC, Wang GP, McClain CJ, Kirpich IA
Journal of lipid research 2019 Dec;60(12):2034-2049
Journal of lipid research 2019 Dec;60(12):2034-2049
Massive centriole production can occur in the absence of deuterosomes in multiciliated cells.
Mercey O, Levine MS, LoMastro GM, Rostaing P, Brotslaw E, Gomez V, Kumar A, Spassky N, Mitchell BJ, Meunier A, Holland AJ
Nature cell biology 2019 Dec;21(12):1544-1552
Nature cell biology 2019 Dec;21(12):1544-1552
Sperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia.
Tapia R, Perez-Yepez EA, Carlino MJ, Karandikar UC, Kralicek SE, Estes MK, Hecht GA
Gastroenterology 2019 Dec;157(6):1544-1555.e3
Gastroenterology 2019 Dec;157(6):1544-1555.e3
The Use of High-Throughput Transcriptomics to Identify Pathways with Therapeutic Significance in Podocytes.
Solanki AK, Srivastava P, Rahman B, Lipschutz JH, Nihalani D, Arif E
International journal of molecular sciences 2019 Dec 31;21(1)
International journal of molecular sciences 2019 Dec 31;21(1)
Phenotypic characteristics of human bone marrow-derived endothelial progenitor cells in vitro support cell effectiveness for repair of the blood-spinal cord barrier in ALS.
Garbuzova-Davis S, Ehrhart J, Mustafa H, Llauget A, Boccio KJ, Sanberg PR, Appel SH, Borlongan CV
Brain research 2019 Dec 1;1724:146428
Brain research 2019 Dec 1;1724:146428
E-cadherin is downregulated in benign prostatic hyperplasia and required for tight junction formation and permeability barrier in the prostatic epithelial cell monolayer.
Li F, Pascal LE, Stolz DB, Wang K, Zhou Y, Chen W, Xu Y, Chen Y, Dhir R, Parwani AV, Nelson JB, DeFranco DB, Yoshimura N, Balasubramani GK, Gingrich JR, Maranchie JK, Jacobs BL, Davies BJ, Hrebinko RL, Bigley JD, McBride D, Guo P, He D, Wang Z
The Prostate 2019 Aug;79(11):1226-1237
The Prostate 2019 Aug;79(11):1226-1237
ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion.
Wilson MR, Reske JJ, Holladay J, Wilber GE, Rhodes M, Koeman J, Adams M, Johnson B, Su RW, Joshi NR, Patterson AL, Shen H, Leach RE, Teixeira JM, Fazleabas AT, Chandler RL
Nature communications 2019 Aug 7;10(1):3554
Nature communications 2019 Aug 7;10(1):3554
Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform.
Achberger K, Probst C, Haderspeck J, Bolz S, Rogal J, Chuchuy J, Nikolova M, Cora V, Antkowiak L, Haq W, Shen N, Schenke-Layland K, Ueffing M, Liebau S, Loskill P
eLife 2019 Aug 27;8
eLife 2019 Aug 27;8
CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells.
Hsu KS, Otsu W, Li Y, Wang HC, Chen S, Tsang SH, Chuang JZ, Sung CH
Scientific reports 2019 Aug 22;9(1):12247
Scientific reports 2019 Aug 22;9(1):12247
Establishment of Primary Transgenic Human Airway Epithelial Cell Cultures to Study Respiratory Virus-Host Interactions.
Jonsdottir HR, Marti S, Geerts D, Rodriguez R, Thiel V, Dijkman R
Viruses 2019 Aug 13;11(8)
Viruses 2019 Aug 13;11(8)
Microtubules are required for the maintenance of planar cell polarity in monociliated floorplate cells.
Mathewson AW, Berman DG, Moens CB
Developmental biology 2019 Aug 1;452(1):21-33
Developmental biology 2019 Aug 1;452(1):21-33
Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria.
Zhou L, Chen X, Lu M, Wu Q, Yuan Q, Hu C, Miao J, Zhang Y, Li H, Hou FF, Nie J, Liu Y
Kidney international 2019 Apr;95(4):830-845
Kidney international 2019 Apr;95(4):830-845
Glibenclamide ameliorates the disrupted blood-brain barrier in experimental intracerebral hemorrhage by inhibiting the activation of NLRP3 inflammasome.
Xu F, Shen G, Su Z, He Z, Yuan L
Brain and behavior 2019 Apr;9(4):e01254
Brain and behavior 2019 Apr;9(4):e01254
Serine Threonine Kinase 17A Maintains the Epithelial State in Colorectal Cancer Cells.
Short SP, Thompson JJ, Bilotta AJ, Chen X, Revetta FL, Washington MK, Williams CS
Molecular cancer research : MCR 2019 Apr;17(4):882-894
Molecular cancer research : MCR 2019 Apr;17(4):882-894
Regulation of cilia abundance in multiciliated cells.
Nanjundappa R, Kong D, Shim K, Stearns T, Brody SL, Loncarek J, Mahjoub MR
eLife 2019 Apr 26;8
eLife 2019 Apr 26;8
Determining the Replication Kinetics and Cellular Tropism of Influenza D Virus on Primary Well-Differentiated Human Airway Epithelial Cells.
Holwerda M, Kelly J, Laloli L, Stürmer I, Portmann J, Stalder H, Dijkman R
Viruses 2019 Apr 24;11(4)
Viruses 2019 Apr 24;11(4)
The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt-Sox9 signaling.
Cohen J, Raviv S, Adir O, Padmanabhan K, Soffer A, Luxenburg C
The Journal of cell biology 2019 Apr 1;218(4):1390-1406
The Journal of cell biology 2019 Apr 1;218(4):1390-1406
Afadin Downregulation by Helicobacter pylori Induces Epithelial to Mesenchymal Transition in Gastric Cells.
Marques MS, Melo J, Cavadas B, Mendes N, Pereira L, Carneiro F, Figueiredo C, Leite M
Frontiers in microbiology 2018;9:2712
Frontiers in microbiology 2018;9:2712
Dynamic Formation of Microvillus Inclusions During Enterocyte Differentiation in Munc18-2-Deficient Intestinal Organoids.
Mosa MH, Nicolle O, Maschalidi S, Sepulveda FE, Bidaud-Meynard A, Menche C, Michels BE, Michaux G, de Saint Basile G, Farin HF
Cellular and molecular gastroenterology and hepatology 2018;6(4):477-493.e1
Cellular and molecular gastroenterology and hepatology 2018;6(4):477-493.e1
Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs.
Chen H, Lu R, Zhang YG, Sun J
Tissue barriers 2018;6(4):1-13
Tissue barriers 2018;6(4):1-13
Brain Barrier Disruption and Region-Specific Neuronal Degeneration during Necrotizing Enterocolitis in Preterm Pigs.
Brunse A, Abbaspour A, Sangild PT
Developmental neuroscience 2018;40(3):198-208
Developmental neuroscience 2018;40(3):198-208
Cyp1b1 expression impacts the angiogenic and inflammatory properties of liver sinusoidal endothelial cells.
Falero-Perez J, Song YS, Zhao Y, Teixeira L, Sorenson CM, Sheibani N
PloS one 2018;13(10):e0206756
PloS one 2018;13(10):e0206756
Protective Effects of L-902,688, a Prostanoid EP4 Receptor Agonist, against Acute Blood-Brain Barrier Damage in Experimental Ischemic Stroke.
DeMars KM, McCrea AO, Siwarski DM, Sanz BD, Yang C, Candelario-Jalil E
Frontiers in neuroscience 2018;12:89
Frontiers in neuroscience 2018;12:89
TLR2 Ligand Pam3CSK4 Regulates MMP-2/9 Expression by MAPK/NF-κB Signaling Pathways in Primary Brain Microvascular Endothelial Cells.
Zhu H, Dai R, Zhou Y, Fu H, Meng Q
Neurochemical research 2018 Oct;43(10):1897-1904
Neurochemical research 2018 Oct;43(10):1897-1904
Retinoic acid signaling is essential for maintenance of the blood-retinal barrier.
Pollock LM, Xie J, Bell BA, Anand-Apte B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5674-5684
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5674-5684
Calprotectin protects against experimental colonic inflammation in mice.
Aranda CJ, Ocón B, Arredondo-Amador M, Suárez MD, Zarzuelo A, Chazin WJ, Martínez-Augustin O, Sánchez de Medina F
British journal of pharmacology 2018 Oct;175(19):3797-3812
British journal of pharmacology 2018 Oct;175(19):3797-3812
Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles.
Dong B, Vold S, Olvera-Jaramillo C, Chang H
Development (Cambridge, England) 2018 Oct 8;145(19)
Development (Cambridge, England) 2018 Oct 8;145(19)
Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate.
Hashi K, Imai C, Yahara K, Tahmina K, Hayashi T, Azuma T, Miyabe-Nishiwaki T, Sato H, Matsuoka M, Niimi S, Okamoto M, Hatakeyama M
Scientific reports 2018 Oct 29;8(1):15981
Scientific reports 2018 Oct 29;8(1):15981
Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation.
Mehta SR, Tom CM, Wang Y, Bresee C, Rushton D, Mathkar PP, Tang J, Mattis VB
Cell reports 2018 Oct 23;25(4):1081-1096.e6
Cell reports 2018 Oct 23;25(4):1081-1096.e6
Human Defensin-5 Blocks Ethanol and Colitis-Induced Dysbiosis, Tight Junction Disruption and Inflammation in Mouse Intestine.
Shukla PK, Meena AS, Rao V, Rao RG, Balazs L, Rao R
Scientific reports 2018 Nov 2;8(1):16241
Scientific reports 2018 Nov 2;8(1):16241
Effects of 17β-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse Model.
Song CH, Kim N, Sohn SH, Lee SM, Nam RH, Na HY, Lee DH, Surh YJ
Gut and liver 2018 Nov 15;12(6):682-693
Gut and liver 2018 Nov 15;12(6):682-693
Stromal fibroblast activation protein alpha promotes gastric cancer progression via epithelial-mesenchymal transition through Wnt/ β-catenin pathway.
Liu J, Huang C, Peng C, Xu F, Li Y, Yutaka Y, Xiong B, Yang X
BMC cancer 2018 Nov 12;18(1):1099
BMC cancer 2018 Nov 12;18(1):1099
Nephron-specific knockin of the PIKfyve-binding-deficient Vac14(L156R) mutant results in albuminuria and mesangial expansion.
Michgehl U, Skryabin BV, Bayraktar S, Vollenbröker B, Ciarimboli G, Heitplatz B, Van Marck V, Gröne HJ, Pavenstädt H, Weide T
American journal of physiology. Renal physiology 2018 Nov 1;315(5):F1307-F1319
American journal of physiology. Renal physiology 2018 Nov 1;315(5):F1307-F1319
Dynein 1 supports spermatid transport and spermiation during spermatogenesis in the rat testis.
Wen Q, Tang EI, Lui WY, Lee WM, Wong CKC, Silvestrini B, Cheng CY
American journal of physiology. Endocrinology and metabolism 2018 Nov 1;315(5):E924-E948
American journal of physiology. Endocrinology and metabolism 2018 Nov 1;315(5):E924-E948
Postpartum increases in cerebral edema and inflammation in response to placental ischemia during pregnancy.
Clayton AM, Shao Q, Paauw ND, Giambrone AB, Granger JP, Warrington JP
Brain, behavior, and immunity 2018 May;70:376-389
Brain, behavior, and immunity 2018 May;70:376-389
CLAMP/Spef1 regulates planar cell polarity signaling and asymmetric microtubule accumulation in the Xenopus ciliated epithelia.
Kim SK, Zhang S, Werner ME, Brotslaw EJ, Mitchell JW, Altabbaa MM, Mitchell BJ
The Journal of cell biology 2018 May 7;217(5):1633-1641
The Journal of cell biology 2018 May 7;217(5):1633-1641
Regulation of blood-testis barrier assembly in vivo by germ cells.
Li XY, Zhang Y, Wang XX, Jin C, Wang YQ, Sun TC, Li J, Tang JX, Batool A, Deng SL, Chen SR, Cheng CY, Liu YX
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Mar;32(3):1653-1664
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Mar;32(3):1653-1664
Neural progenitor fate decision defects, cortical hypoplasia and behavioral impairment in Celsr1-deficient mice.
Boucherie C, Boutin C, Jossin Y, Schakman O, Goffinet AM, Ris L, Gailly P, Tissir F
Molecular psychiatry 2018 Mar;23(3):723-734
Molecular psychiatry 2018 Mar;23(3):723-734
Requirement of the F-actin-binding activity of l-afadin for enhancing the formation of adherens and tight junctions.
Sakakibara S, Maruo T, Miyata M, Mizutani K, Takai Y
Genes to cells : devoted to molecular & cellular mechanisms 2018 Mar;23(3):185-199
Genes to cells : devoted to molecular & cellular mechanisms 2018 Mar;23(3):185-199
Sleep deprivation disrupts the lacrimal system and induces dry eye disease.
Li S, Ning K, Zhou J, Guo Y, Zhang H, Zhu Y, Zhang L, Jia C, Chen Y, Sol Reinach P, Liu Z, Li W
Experimental & molecular medicine 2018 Mar 2;50(3):e451
Experimental & molecular medicine 2018 Mar 2;50(3):e451
Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.
Poppe D, Doerr J, Schneider M, Wilkens R, Steinbeck JA, Ladewig J, Tam A, Paschon DE, Gregory PD, Reik A, Müller CE, Koch P, Brüstle O
Stem cells translational medicine 2018 Jun;7(6):477-486
Stem cells translational medicine 2018 Jun;7(6):477-486
MicroRNA-Mediated Therapy Modulating Blood-Brain Barrier Disruption Improves Vascular Cognitive Impairment.
Toyama K, Spin JM, Deng AC, Huang TT, Wei K, Wagenhäuser MU, Yoshino T, Nguyen H, Mulorz J, Kundu S, Raaz U, Adam M, Schellinger IN, Jagger A, Tsao PS
Arteriosclerosis, thrombosis, and vascular biology 2018 Jun;38(6):1392-1406
Arteriosclerosis, thrombosis, and vascular biology 2018 Jun;38(6):1392-1406
Delivery of CR2-fH Using AAV Vector Therapy as Treatment Strategy in the Mouse Model of Choroidal Neovascularization.
Schnabolk G, Parsons N, Obert E, Annamalai B, Nasarre C, Tomlinson S, Lewin AS, Rohrer B
Molecular therapy. Methods & clinical development 2018 Jun 15;9:1-11
Molecular therapy. Methods & clinical development 2018 Jun 15;9:1-11
The atypical mitogen-activated protein kinase ERK3 is essential for establishment of epithelial architecture.
Takahashi C, Miyatake K, Kusakabe M, Nishida E
The Journal of biological chemistry 2018 Jun 1;293(22):8342-8361
The Journal of biological chemistry 2018 Jun 1;293(22):8342-8361
Immunohistochemistry in Investigative and Toxicologic Pathology.
Janardhan KS, Jensen H, Clayton NP, Herbert RA
Toxicologic pathology 2018 Jul;46(5):488-510
Toxicologic pathology 2018 Jul;46(5):488-510
HDAC inhibitors, trichostatin A and valproic acid, increase E‑cadherin and vimentin expression but inhibit migration and invasion of cholangiocarcinoma cells.
Wang JH, Lee EJ, Ji M, Park SM
Oncology reports 2018 Jul;40(1):346-354
Oncology reports 2018 Jul;40(1):346-354
0.005% Preservative-Free Latanoprost Induces Dry Eye-Like Ocular Surface Damage via Promotion of Inflammation in Mice.
Yang Y, Huang C, Lin X, Wu Y, Ouyang W, Tang L, Ye S, Wang Y, Li W, Zhang X, Liu Z
Investigative ophthalmology & visual science 2018 Jul 2;59(8):3375-3384
Investigative ophthalmology & visual science 2018 Jul 2;59(8):3375-3384
Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases.
Gril B, Paranjape AN, Woditschka S, Hua E, Dolan EL, Hanson J, Wu X, Kloc W, Izycka-Swieszewska E, Duchnowska R, Pęksa R, Biernat W, Jassem J, Nayyar N, Brastianos PK, Hall OM, Peer CJ, Figg WD, Pauly GT, Robinson C, Difilippantonio S, Bialecki E, Metellus P, Schneider JP, Steeg PS
Nature communications 2018 Jul 13;9(1):2705
Nature communications 2018 Jul 13;9(1):2705
Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport.
Muroyama A, Terwilliger M, Dong B, Suh H, Lechler T
Molecular biology of the cell 2018 Jul 1;29(13):1533-1541
Molecular biology of the cell 2018 Jul 1;29(13):1533-1541
Ectodysplasin A regulates epithelial barrier function through sonic hedgehog signalling pathway.
Li S, Zhou J, Zhang L, Li J, Yu J, Ning K, Qu Y, He H, Chen Y, Reinach PS, Liu CY, Liu Z, Li W
Journal of cellular and molecular medicine 2018 Jan;22(1):230-240
Journal of cellular and molecular medicine 2018 Jan;22(1):230-240
FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction.
Zhou SY, Gillilland M 3rd, Wu X, Leelasinjaroen P, Zhang G, Zhou H, Ye B, Lu Y, Owyang C
The Journal of clinical investigation 2018 Jan 2;128(1):267-280
The Journal of clinical investigation 2018 Jan 2;128(1):267-280
Dacomitinib-induced diarrhea: Targeting chloride secretion with crofelemer.
Van Sebille YZA, Gibson RJ, Wardill HR, Ball IA, Keefe DMK, Bowen JM
International journal of cancer 2018 Jan 15;142(2):369-380
International journal of cancer 2018 Jan 15;142(2):369-380
Enteropathogenic E. coli effectors EspF and Map independently disrupt tight junctions through distinct mechanisms involving transcriptional and post-transcriptional regulation.
Singh AP, Sharma S, Pagarware K, Siraji RA, Ansari I, Mandal A, Walling P, Aijaz S
Scientific reports 2018 Feb 27;8(1):3719
Scientific reports 2018 Feb 27;8(1):3719
Human Primary Cell-Based Organotypic Microtissues for Modeling Small Intestinal Drug Absorption.
Ayehunie S, Landry T, Stevens Z, Armento A, Hayden P, Klausner M
Pharmaceutical research 2018 Feb 23;35(4):72
Pharmaceutical research 2018 Feb 23;35(4):72
Light action spectrum on oxidative stress and mitochondrial damage in A2E-loaded retinal pigment epithelium cells.
Marie M, Bigot K, Angebault C, Barrau C, Gondouin P, Pagan D, Fouquet S, Villette T, Sahel JA, Lenaers G, Picaud S
Cell death & disease 2018 Feb 19;9(3):287
Cell death & disease 2018 Feb 19;9(3):287
Reassembly of adult human testicular cells: can testis cord-like structures be created in vitro?
Mincheva M, Sandhowe-Klaverkamp R, Wistuba J, Redmann K, Stukenborg JB, Kliesch S, Schlatt S
Molecular human reproduction 2018 Feb 1;24(2):55-63
Molecular human reproduction 2018 Feb 1;24(2):55-63
Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation.
Zhao M, Xiong X, Ren K, Xu B, Cheng M, Sahu C, Wu K, Nie Y, Huang Z, Blumberg RS, Han X, Ruan HB
EMBO molecular medicine 2018 Aug;10(8)
EMBO molecular medicine 2018 Aug;10(8)
PyMT-1099, a versatile murine cell model for EMT in breast cancer.
Saxena M, Kalathur RKR, Neutzner M, Christofori G
Scientific reports 2018 Aug 14;8(1):12123
Scientific reports 2018 Aug 14;8(1):12123
Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules.
Vormann MK, Gijzen L, Hutter S, Boot L, Nicolas A, van den Heuvel A, Vriend J, Ng CP, Nieskens TTG, van Duinen V, de Wagenaar B, Masereeuw R, Suter-Dick L, Trietsch SJ, Wilmer M, Joore J, Vulto P, Lanz HL
The AAPS journal 2018 Aug 14;20(5):90
The AAPS journal 2018 Aug 14;20(5):90
β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability.
Izawa Y, Gu YH, Osada T, Kanazawa M, Hawkins BT, Koziol JA, Papayannopoulou T, Spatz M, Del Zoppo GJ
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2018 Apr;38(4):641-658
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2018 Apr;38(4):641-658
Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis.
Benhamouche-Trouillet S, O'Loughlin E, Liu CH, Polacheck W, Fitamant J, McKee M, El-Bardeesy N, Chen CS, McClatchey AI
Development (Cambridge, England) 2018 Apr 30;145(9)
Development (Cambridge, England) 2018 Apr 30;145(9)
Bis-Retinoid A2E Induces an Increase of Basic Fibroblast Growth Factor via Inhibition of Extracellular Signal-Regulated Kinases 1/2 Pathway in Retinal Pigment Epithelium Cells and Facilitates Phagocytosis.
Balmer D, Bapst-Wicht L, Pyakurel A, Emery M, Nanchen N, Bochet CG, Roduit R
Frontiers in aging neuroscience 2017;9:43
Frontiers in aging neuroscience 2017;9:43
Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells.
Samuel W, Jaworski C, Postnikova OA, Kutty RK, Duncan T, Tan LX, Poliakov E, Lakkaraju A, Redmond TM
Molecular vision 2017;23:60-89
Molecular vision 2017;23:60-89
Protective barrier properties of Rhinosectan(®) spray (containing xyloglucan) on an organotypic 3D airway tissue model (MucilAir): results of an in vitro study.
De Servi B, Ranzini F, Piqué N
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2017;13:37
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2017;13:37
Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration.
Geng Z, Walsh PJ, Truong V, Hill C, Ebeling M, Kapphahn RJ, Montezuma SR, Yuan C, Roehrich H, Ferrington DA, Dutton JR
PloS one 2017;12(3):e0173575
PloS one 2017;12(3):e0173575
Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite.
Jaworska K, Huc T, Samborowska E, Dobrowolski L, Bielinska K, Gawlak M, Ufnal M
PloS one 2017;12(12):e0189310
PloS one 2017;12(12):e0189310
Netrin-1 Ameliorates Blood-Brain Barrier Impairment Secondary to Ischemic Stroke via the Activation of PI3K Pathway.
Yu J, Li C, Ding Q, Que J, Liu K, Wang H, Liao S
Frontiers in neuroscience 2017;11:700
Frontiers in neuroscience 2017;11:700
Puerarin transport across rat nasal epithelial cells and the influence of compatibility with peoniflorin and menthol.
Zhang L, Du SY, Lu Y, Liu C, Wu HC, Tian ZH, Wang M, Yang C
Drug design, development and therapy 2017;11:2581-2593
Drug design, development and therapy 2017;11:2581-2593
Human salivary peptide histatin-1 stimulates epithelial and endothelial cell adhesion and barrier function.
van Dijk IA, Ferrando ML, van der Wijk AE, Hoebe RA, Nazmi K, de Jonge WJ, Krawczyk PM, Bolscher JGM, Veerman ECI, Stap J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Sep;31(9):3922-3933
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Sep;31(9):3922-3933
Epithelial expression and function of trypsin-3 in irritable bowel syndrome.
Rolland-Fourcade C, Denadai-Souza A, Cirillo C, Lopez C, Jaramillo JO, Desormeaux C, Cenac N, Motta JP, Larauche M, Taché Y, Vanden Berghe P, Neunlist M, Coron E, Kirzin S, Portier G, Bonnet D, Alric L, Vanner S, Deraison C, Vergnolle N
Gut 2017 Oct;66(10):1767-1778
Gut 2017 Oct;66(10):1767-1778
Blood-spinal cord barrier breakdown and pericyte deficiency in peripheral neuropathy.
Sauer RS, Kirchner J, Yang S, Hu L, Leinders M, Sommer C, Brack A, Rittner HL
Annals of the New York Academy of Sciences 2017 Oct;1405(1):71-88
Annals of the New York Academy of Sciences 2017 Oct;1405(1):71-88
Cell-specific diversity in the expression and organization of cytoplasmic plaque proteins of apical junctions.
Vasileva E, Sluysmans S, Bochaton-Piallat ML, Citi S
Annals of the New York Academy of Sciences 2017 Oct;1405(1):160-176
Annals of the New York Academy of Sciences 2017 Oct;1405(1):160-176
Stem Cell Derived Retinal Pigment Epithelium: The Role of Pigmentation as Maturation Marker and Gene Expression Profile Comparison with Human Endogenous Retinal Pigment Epithelium.
Bennis A, Jacobs JG, Catsburg LAE, Ten Brink JB, Koster C, Schlingemann RO, van Meurs J, Gorgels TGMF, Moerland PD, Heine VM, Bergen AA
Stem cell reviews and reports 2017 Oct;13(5):659-669
Stem cell reviews and reports 2017 Oct;13(5):659-669
Genome editing reveals a role for OCT4 in human embryogenesis.
Fogarty NME, McCarthy A, Snijders KE, Powell BE, Kubikova N, Blakeley P, Lea R, Elder K, Wamaitha SE, Kim D, Maciulyte V, Kleinjung J, Kim JS, Wells D, Vallier L, Bertero A, Turner JMA, Niakan KK
Nature 2017 Oct 5;550(7674):67-73
Nature 2017 Oct 5;550(7674):67-73
Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.
Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na CL, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Ochs M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, Wambach J, Whitsett JA, Cole FS, Morrisey EE, Guttentag SH, Beers MF, Kotton DN
Cell stem cell 2017 Oct 5;21(4):472-488.e10
Cell stem cell 2017 Oct 5;21(4):472-488.e10
miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis.
Diepenbruck M, Tiede S, Saxena M, Ivanek R, Kalathur RKR, Lüönd F, Meyer-Schaller N, Christofori G
Nature communications 2017 Oct 27;8(1):1168
Nature communications 2017 Oct 27;8(1):1168
Olaquindox disrupts tight junction integrity and cytoskeleton architecture in mouse Sertoli cells.
Wu D, Huang CJ, Jiao XF, Ding ZM, Zhang JY, Chen F, Wang YS, Li X, Huo LJ
Oncotarget 2017 Oct 24;8(51):88630-88644
Oncotarget 2017 Oct 24;8(51):88630-88644
Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro.
Hassell BA, Goyal G, Lee E, Sontheimer-Phelps A, Levy O, Chen CS, Ingber DE
Cell reports 2017 Oct 10;21(2):508-516
Cell reports 2017 Oct 10;21(2):508-516
FK506 suppresses hypoxia‑induced inflammation and protects tight junction function via the CaN‑NFATc1 signaling pathway in retinal microvascular epithelial cells.
Hu Y, Yang B, Xu Y, Jiang L, Tsui CK, Liang X
Molecular medicine reports 2017 Nov;16(5):6974-6980
Molecular medicine reports 2017 Nov;16(5):6974-6980
Context-dependent compensation among phosphatidylserine-recognition receptors.
Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS
Scientific reports 2017 Nov 7;7(1):14623
Scientific reports 2017 Nov 7;7(1):14623
Cell-cell adhesion accounts for the different orientation of columnar and hepatocytic cell divisions.
Lázaro-Diéguez F, Müsch A
The Journal of cell biology 2017 Nov 6;216(11):3847-3859
The Journal of cell biology 2017 Nov 6;216(11):3847-3859
Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations.
Lopez-Ramirez MA, Fonseca G, Zeineddine HA, Girard R, Moore T, Pham A, Cao Y, Shenkar R, de Kreuk BJ, Lagarrigue F, Lawler J, Glass CK, Awad IA, Ginsberg MH
The Journal of experimental medicine 2017 Nov 6;214(11):3331-3346
The Journal of experimental medicine 2017 Nov 6;214(11):3331-3346
FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development.
Sahu SK, Tiwari N, Pataskar A, Zhuang Y, Borisova M, Diken M, Strand S, Beli P, Tiwari VK
Nature communications 2017 Nov 15;8(1):1523
Nature communications 2017 Nov 15;8(1):1523
Lamin Cleavage: A Reliable Marker for Studying Staurosporine-Induced Apoptosis in Corneal Tissue.
Mahajan S, Thieme D, Czugala M, Kruse FE, Fuchsluger TA
Investigative ophthalmology & visual science 2017 Nov 1;58(13):5802-5809
Investigative ophthalmology & visual science 2017 Nov 1;58(13):5802-5809
Direct and efficient transfection of mouse neural stem cells and mature neurons by in vivo mRNA electroporation.
Bugeon S, de Chevigny A, Boutin C, Coré N, Wild S, Bosio A, Cremer H, Beclin C
Development (Cambridge, England) 2017 Nov 1;144(21):3968-3977
Development (Cambridge, England) 2017 Nov 1;144(21):3968-3977
Targeting the tight junction protein, zonula occludens-1, with the connexin43 mimetic peptide, αCT1, reduces VEGF-dependent RPE pathophysiology.
Obert E, Strauss R, Brandon C, Grek C, Ghatnekar G, Gourdie R, Rohrer B
Journal of molecular medicine (Berlin, Germany) 2017 May;95(5):535-552
Journal of molecular medicine (Berlin, Germany) 2017 May;95(5):535-552
Inflammatory demyelination induces ependymal modifications concomitant to activation of adult (SVZ) stem cell proliferation.
Pourabdolhossein F, Gil-Perotín S, Garcia-Belda P, Dauphin A, Mozafari S, Tepavcevic V, Manuel Garcia Verdugo J, Baron-Van Evercooren A
Glia 2017 May;65(5):756-772
Glia 2017 May;65(5):756-772
VIP Family Members Prevent Outer Blood Retinal Barrier Damage in a Model of Diabetic Macular Edema.
Maugeri G, D'Amico AG, Gagliano C, Saccone S, Federico C, Cavallaro S, D'Agata V
Journal of cellular physiology 2017 May;232(5):1079-1085
Journal of cellular physiology 2017 May;232(5):1079-1085
Aging-dependent expression of synapse-related proteins in the mouse brain.
Shiotani H, Maruo T, Sakakibara S, Miyata M, Mandai K, Mochizuki H, Takai Y
Genes to cells : devoted to molecular & cellular mechanisms 2017 May;22(5):472-484
Genes to cells : devoted to molecular & cellular mechanisms 2017 May;22(5):472-484
Variants of β-casofensin, a bioactive milk peptide, differently modulate the intestinal barrier: In vivo and ex vivo studies in rats.
Bruno J, Nicolas A, Pesenti S, Schwarz J, Simon JL, Léonil J, Plaisancié P
Journal of dairy science 2017 May;100(5):3360-3372
Journal of dairy science 2017 May;100(5):3360-3372
Plastic roles of pericytes in the blood-retinal barrier.
Park DY, Lee J, Kim J, Kim K, Hong S, Han S, Kubota Y, Augustin HG, Ding L, Kim JW, Kim H, He Y, Adams RH, Koh GY
Nature communications 2017 May 16;8:15296
Nature communications 2017 May 16;8:15296
Establishment, maintenance and functional integrity of the blood-testis barrier in organotypic cultures of fresh and frozen/thawed prepubertal mouse testes.
Rondanino C, Maouche A, Dumont L, Oblette A, Rives N
Molecular human reproduction 2017 May 1;23(5):304-320
Molecular human reproduction 2017 May 1;23(5):304-320
Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway.
Sivagurunathan S, Palanisamy K, Arunachalam JP, Chidambaram S
Molecular and cellular biochemistry 2017 Mar;427(1-2):145-156
Molecular and cellular biochemistry 2017 Mar;427(1-2):145-156
Culture media-based selection of endothelial cells, pericytes, and perivascular-resident macrophage-like melanocytes from the young mouse vestibular system.
Zhang J, Chen S, Cai J, Hou Z, Wang X, Kachelmeier A, Shi X
Hearing research 2017 Mar;345:10-22
Hearing research 2017 Mar;345:10-22
Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier.
Thomsen MS, Birkelund S, Burkhart A, Stensballe A, Moos T
Journal of neurochemistry 2017 Mar;140(5):741-754
Journal of neurochemistry 2017 Mar;140(5):741-754
Knockdown of long non-coding RNA XIST increases blood-tumor barrier permeability and inhibits glioma angiogenesis by targeting miR-137.
Yu H, Xue Y, Wang P, Liu X, Ma J, Zheng J, Li Z, Li Z, Cai H, Liu Y
Oncogenesis 2017 Mar 13;6(3):e303
Oncogenesis 2017 Mar 13;6(3):e303
Protective Effect of Met12, a Small Peptide Inhibitor of Fas, on the Retinal Pigment Epithelium and Photoreceptor After Sodium Iodate Injury.
Xiao J, Yao J, Jia L, Lin C, Zacks DN
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1801-1810
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1801-1810
Ghrelin ameliorates blood-brain barrier disruption during systemic hypoxia.
Mohaddes G, Abdolalizadeh J, Babri S, Hossienzadeh F
Experimental physiology 2017 Mar 1;102(3):376-382
Experimental physiology 2017 Mar 1;102(3):376-382
Par3 in chick lens placode development.
Melo MO, Moraes Borges R, Yan CYI
Genesis (New York, N.Y. : 2000) 2017 Jun;55(6)
Genesis (New York, N.Y. : 2000) 2017 Jun;55(6)
Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration.
Zaritsky A, Tseng YY, Rabadán MA, Krishna S, Overholtzer M, Danuser G, Hall A
The Journal of cell biology 2017 Jun 5;216(6):1543-1556
The Journal of cell biology 2017 Jun 5;216(6):1543-1556
Pten facilitates epiblast epithelial polarization and proamniotic lumen formation in early mouse embryos.
Meng Y, Cai KQ, Moore R, Tao W, Tse JD, Smith ER, Xu XX
Developmental dynamics : an official publication of the American Association of Anatomists 2017 Jul;246(7):517-530
Developmental dynamics : an official publication of the American Association of Anatomists 2017 Jul;246(7):517-530
TRPV4 Regulates Tight Junctions and Affects Differentiation in a Cell Culture Model of the Corneal Epithelium.
Martínez-Rendón J, Sánchez-Guzmán E, Rueda A, González J, Gulias-Cañizo R, Aquino-Jarquín G, Castro-Muñozledo F, García-Villegas R
Journal of cellular physiology 2017 Jul;232(7):1794-1807
Journal of cellular physiology 2017 Jul;232(7):1794-1807
Effects of MMP12 on cell motility and inflammation during corneal epithelial repair.
Wolf M, Maltseva I, Clay SM, Pan P, Gajjala A, Chan MF
Experimental eye research 2017 Jul;160:11-20
Experimental eye research 2017 Jul;160:11-20
Leptospira interrogans causes quantitative and morphological disturbances in adherens junctions and other biological groups of proteins in human endothelial cells.
Sato H, Coburn J
PLoS neglected tropical diseases 2017 Jul;11(7):e0005830
PLoS neglected tropical diseases 2017 Jul;11(7):e0005830
Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1-fibronectin links.
González-Tarragó V, Elosegui-Artola A, Bazellières E, Oria R, Pérez-González C, Roca-Cusachs P
Molecular biology of the cell 2017 Jul 7;28(14):1847-1852
Molecular biology of the cell 2017 Jul 7;28(14):1847-1852
Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment.
Lewis MC, Merrifield CA, Berger B, Cloarec O, Duncker S, Mercenier A, Nicholson JK, Holmes E, Bailey M
Scientific reports 2017 Jul 13;7(1):5310
Scientific reports 2017 Jul 13;7(1):5310
Defective CFTR leads to aberrant β-catenin activation and kidney fibrosis.
Zhang JT, Wang Y, Chen JJ, Zhang XH, Dong JD, Tsang LL, Huang XR, Cai Z, Lan HY, Jiang XH, Chan HC
Scientific reports 2017 Jul 12;7(1):5233
Scientific reports 2017 Jul 12;7(1):5233
Mitosis can drive cell cannibalism through entosis.
Durgan J, Tseng YY, Hamann JC, Domart MC, Collinson L, Hall A, Overholtzer M, Florey O
eLife 2017 Jul 11;6
eLife 2017 Jul 11;6
Urban fine particulate matter exposure causes male reproductive injury through destroying blood-testis barrier (BTB) integrity.
Cao XN, Shen LJ, Wu SD, Yan C, Zhou Y, Xiong G, Wang YC, Liu Y, Liu B, Tang XL, Guo M, Liu DY, Long CL, Sun M, He DW, Lin T, Wei GH
Toxicology letters 2017 Jan 15;266:1-12
Toxicology letters 2017 Jan 15;266:1-12
Proliferation-independent regulation of organ size by Fgf/Notch signaling.
Kozlovskaja-Gumbrienė A, Yi R, Alexander R, Aman A, Jiskra R, Nagelberg D, Knaut H, McClain M, Piotrowski T
eLife 2017 Jan 13;6
eLife 2017 Jan 13;6
ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens.
Priya R, Liang X, Teo JL, Duszyc K, Yap AS, Gomez GA
Molecular biology of the cell 2017 Jan 1;28(1):12-20
Molecular biology of the cell 2017 Jan 1;28(1):12-20
Deep nuclear invaginations are linked to cytoskeletal filaments - integrated bioimaging of epithelial cells in 3D culture.
Jorgens DM, Inman JL, Wojcik M, Robertson C, Palsdottir H, Tsai WT, Huang H, Bruni-Cardoso A, López CS, Bissell MJ, Xu K, Auer M
Journal of cell science 2017 Jan 1;130(1):177-189
Journal of cell science 2017 Jan 1;130(1):177-189
Regulation of the blood-testis barrier by a local axis in the testis: role of laminin α2 in the basement membrane.
Gao Y, Mruk D, Chen H, Lui WY, Lee WM, Cheng CY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Feb;31(2):584-597
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Feb;31(2):584-597
Low-Dose Lipopolysaccharide Causes Biliary Injury by Blood Biliary Barrier Impairment in a Rat Hepatic Ischemia/Reperfusion Model.
Reiling J, Bridle KR, Gijbels M, Schaap FG, Jaskowski L, Santrampurwala N, Britton LJ, Campbell CM, Olde Damink SW, Crawford DH, Dejong CH, Fawcett J
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2017 Feb;23(2):194-206
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2017 Feb;23(2):194-206
Autophagy and KRT8/keratin 8 protect degeneration of retinal pigment epithelium under oxidative stress.
Baek A, Yoon S, Kim J, Baek YM, Park H, Lim D, Chung H, Kim DE
Autophagy 2017 Feb;13(2):248-263
Autophagy 2017 Feb;13(2):248-263
Development of an in vitro co-culture model to mimic the human intestine in healthy and diseased state.
Kämpfer AAM, Urbán P, Gioria S, Kanase N, Stone V, Kinsner-Ovaskainen A
Toxicology in vitro : an international journal published in association with BIBRA 2017 Dec;45(Pt 1):31-43
Toxicology in vitro : an international journal published in association with BIBRA 2017 Dec;45(Pt 1):31-43
Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia.
Ly H, Verma N, Wu F, Liu M, Saatman KE, Nelson PT, Slevin JT, Goldstein LB, Biessels GJ, Despa F
Annals of neurology 2017 Aug;82(2):208-222
Annals of neurology 2017 Aug;82(2):208-222
Matrix metalloproteinase-2 and -9 contribute to functional integrity and noise‑induced damage to the blood-labyrinth-barrier.
Wu J, Han W, Chen X, Guo W, Liu K, Wang R, Zhang J, Sai N
Molecular medicine reports 2017 Aug;16(2):1731-1738
Molecular medicine reports 2017 Aug;16(2):1731-1738
Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes.
Trietsch SJ, Naumovska E, Kurek D, Setyawati MC, Vormann MK, Wilschut KJ, Lanz HL, Nicolas A, Ng CP, Joore J, Kustermann S, Roth A, Hankemeier T, Moisan A, Vulto P
Nature communications 2017 Aug 15;8(1):262
Nature communications 2017 Aug 15;8(1):262
Descemet's Membrane Supports Corneal Endothelial Cell Regeneration in Rabbits.
Chen J, Li Z, Zhang L, Ou S, Wang Y, He X, Zou D, Jia C, Hu Q, Yang S, Li X, Li J, Wang J, Sun H, Chen Y, Zhu YT, Tseng SCG, Liu Z, Li W
Scientific reports 2017 Aug 1;7(1):6983
Scientific reports 2017 Aug 1;7(1):6983
Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury.
Chehaibi K, le Maire L, Bradoni S, Escola JC, Blanco-Vaca F, Slimane MN
Translational research : the journal of laboratory and clinical medicine 2017 Apr;182:27-48
Translational research : the journal of laboratory and clinical medicine 2017 Apr;182:27-48
A responsive human triple-culture model of the air-blood barrier: incorporation of different macrophage phenotypes.
Kasper JY, Hermanns MI, Unger RE, Kirkpatrick CJ
Journal of tissue engineering and regenerative medicine 2017 Apr;11(4):1285-1297
Journal of tissue engineering and regenerative medicine 2017 Apr;11(4):1285-1297
ERK signalling modulates epigenome to drive epithelial to mesenchymal transition.
Navandar M, Garding A, Sahu SK, Pataskar A, Schick S, Tiwari VK
Oncotarget 2017 Apr 25;8(17):29269-29281
Oncotarget 2017 Apr 25;8(17):29269-29281
Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1.
Yanagida K, Liu CH, Faraco G, Galvani S, Smith HK, Burg N, Anrather J, Sanchez T, Iadecola C, Hla T
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 25;114(17):4531-4536
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 25;114(17):4531-4536
Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease.
Lenis TL, Sarfare S, Jiang Z, Lloyd MB, Bok D, Radu RA
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 11;114(15):3987-3992
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 11;114(15):3987-3992
Glioma-associated oncogene homolog 1 promotes epithelial-mesenchymal transition in human renal tubular epithelial cell.
Ding H, Xu Y, Gao D, Wang L
American journal of translational research 2016;8(2):662-9
American journal of translational research 2016;8(2):662-9
Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier.
Kuehn A, Kletting S, de Souza Carvalho-Wodarz C, Repnik U, Griffiths G, Fischer U, Meese E, Huwer H, Wirth D, May T, Schneider-Daum N, Lehr CM
ALTEX 2016;33(3):251-60
ALTEX 2016;33(3):251-60
Differentiation/Purification Protocol for Retinal Pigment Epithelium from Mouse Induced Pluripotent Stem Cells as a Research Tool.
Iwasaki Y, Sugita S, Mandai M, Yonemura S, Onishi A, Ito S, Mochizuki M, Ohno-Matsui K, Takahashi M
PloS one 2016;11(7):e0158282
PloS one 2016;11(7):e0158282
Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition.
Alluri H, Wilson RL, Anasooya Shaji C, Wiggins-Dohlvik K, Patel S, Liu Y, Peng X, Beeram MR, Davis ML, Huang JH, Tharakan B
PloS one 2016;11(5):e0154427
PloS one 2016;11(5):e0154427
Selection of a Relevant In Vitro Blood-Brain Barrier Model to Investigate Pro-Metastatic Features of Human Breast Cancer Cell Lines.
Drolez A, Vandenhaute E, Julien S, Gosselet F, Burchell J, Cecchelli R, Delannoy P, Dehouck MP, Mysiorek C
PloS one 2016;11(3):e0151155
PloS one 2016;11(3):e0151155
The role of the intestinal microvasculature in inflammatory bowel disease: studies with a modified Caco-2 model including endothelial cells resembling the intestinal barrier in vitro.
Kasper JY, Hermanns MI, Cavelius C, Kraegeloh A, Jung T, Danzebrink R, Unger RE, Kirkpatrick CJ
International journal of nanomedicine 2016;11:6353-6364
International journal of nanomedicine 2016;11:6353-6364
A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening.
Skardal A, Devarasetty M, Forsythe S, Atala A, Soker S
Biotechnology and bioengineering 2016 Sep;113(9):2020-32
Biotechnology and bioengineering 2016 Sep;113(9):2020-32
VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation.
Brinkmann BF, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, Nakayama M, Weide T, Gerke V, Ebnet K
Molecular biology of the cell 2016 Sep 15;27(18):2811-21
Molecular biology of the cell 2016 Sep 15;27(18):2811-21
Loss of ZFP36 expression in colorectal cancer correlates to wnt/ ß-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of ZEB1, SOX9 and MACC1.
Montorsi L, Guizzetti F, Alecci C, Caporali A, Martello A, Atene CG, Parenti S, Pizzini S, Zanovello P, Bortoluzzi S, Ferrari S, Grande A, Zanocco-Marani T
Oncotarget 2016 Sep 13;7(37):59144-59157
Oncotarget 2016 Sep 13;7(37):59144-59157
Yes-associated protein impacts adherens junction assembly through regulating actin cytoskeleton organization.
Bai H, Zhu Q, Surcel A, Luo T, Ren Y, Guan B, Liu Y, Wu N, Joseph NE, Wang TL, Zhang N, Pan D, Alpini G, Robinson DN, Anders RA
American journal of physiology. Gastrointestinal and liver physiology 2016 Sep 1;311(3):G396-411
American journal of physiology. Gastrointestinal and liver physiology 2016 Sep 1;311(3):G396-411
Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability.
Wilkinson EL, Sidaway JE, Cross MJ
Biology open 2016 Oct 15;5(10):1362-1370
Biology open 2016 Oct 15;5(10):1362-1370
Dual effects of a high-protein diet on DSS-treated mice during colitis resolution phase.
Lan A, Blais A, Coelho D, Capron J, Maarouf M, Benamouzig R, Lancha AH Jr, Walker F, Tomé D, Blachier F
American journal of physiology. Gastrointestinal and liver physiology 2016 Oct 1;311(4):G624-G633
American journal of physiology. Gastrointestinal and liver physiology 2016 Oct 1;311(4):G624-G633
The impact of autophagy on the development of senescence in primary tubular epithelial cells.
Baisantry A, Bhayana S, Wrede C, Hegermann J, Haller H, Melk A, Schmitt R
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2973-2979
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2973-2979
The role of pericytic laminin in blood brain barrier integrity maintenance.
Gautam J, Zhang X, Yao Y
Scientific reports 2016 Nov 3;6:36450
Scientific reports 2016 Nov 3;6:36450
Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II.
Priya R, Wee K, Budnar S, Gomez GA, Yap AS, Michael M
Cell cycle (Georgetown, Tex.) 2016 Nov 16;15(22):3033-3041
Cell cycle (Georgetown, Tex.) 2016 Nov 16;15(22):3033-3041
Loss of Neurokinin-1 Receptor Alters Ocular Surface Homeostasis and Promotes an Early Development of Herpes Stromal Keratitis.
Gaddipati S, Rao P, Jerome AD, Burugula BB, Gerard NP, Suvas S
Journal of immunology (Baltimore, Md. : 1950) 2016 Nov 15;197(10):4021-4033
Journal of immunology (Baltimore, Md. : 1950) 2016 Nov 15;197(10):4021-4033
Functional roles of MMP14 and MMP15 in early postnatal mammary gland development.
Feinberg TY, Rowe RG, Saunders TL, Weiss SJ
Development (Cambridge, England) 2016 Nov 1;143(21):3956-3968
Development (Cambridge, England) 2016 Nov 1;143(21):3956-3968
Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial-to-mesenchymal transition (EMT) in bladder cancer.
Islam SS, Mokhtari RB, Noman AS, Uddin M, Rahman MZ, Azadi MA, Zlotta A, van der Kwast T, Yeger H, Farhat WA
Molecular carcinogenesis 2016 May;55(5):537-51
Molecular carcinogenesis 2016 May;55(5):537-51
Interleukin 1alpha-induced disruption of the Sertoli cell cytoskeleton affects gap junctional communication.
Chojnacka K, Bilinska B, Mruk DD
Cellular signalling 2016 May;28(5):469-480
Cellular signalling 2016 May;28(5):469-480
Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway.
Kai T, Tsukamoto Y, Hijiya N, Tokunaga A, Nakada C, Uchida T, Daa T, Iha H, Takahashi M, Nomura T, Sato F, Mimata H, Ikawa M, Seto M, Matsuura K, Moriyama M
The Journal of pathology 2016 May;239(1):97-108
The Journal of pathology 2016 May;239(1):97-108
Planar Cell Polarity (PCP) Protein Vangl2 Regulates Ectoplasmic Specialization Dynamics via Its Effects on Actin Microfilaments in the Testes of Male Rats.
Chen H, Mruk DD, Lee WM, Cheng CY
Endocrinology 2016 May;157(5):2140-59
Endocrinology 2016 May;157(5):2140-59
Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.
Maeta K, Edamatsu H, Nishihara K, Ikutomo J, Bilasy SE, Kataoka T
eNeuro 2016 May-Jun;3(3)
eNeuro 2016 May-Jun;3(3)
The blood-tendon barrier: identification and characterisation of a novel tissue barrier in tendon blood vessels.
Lehner C, Gehwolf R, Ek JC, Korntner S, Bauer H, Bauer HC, Traweger A, Tempfer H
European cells & materials 2016 May 26;31:296-311
European cells & materials 2016 May 26;31:296-311
The blood-tendon barrier: identification and characterisation of a novel tissue barrier in tendon blood vessels.
Lehner C, Gehwolf R, Ek JC, Korntner S, Bauer H, Bauer HC, Traweger A, Tempfer H
European cells & materials 2016 May 26;31:296-311
European cells & materials 2016 May 26;31:296-311
PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins.
Guerrera D, Shah J, Vasileva E, Sluysmans S, Méan I, Jond L, Poser I, Mann M, Hyman AA, Citi S
The Journal of biological chemistry 2016 May 20;291(21):11016-29
The Journal of biological chemistry 2016 May 20;291(21):11016-29
MicroRNA-107 prevents amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1.
Liu W, Cai H, Lin M, Zhu L, Gao L, Zhong R, Bi S, Xue Y, Shang X
Experimental cell research 2016 May 1;343(2):248-257
Experimental cell research 2016 May 1;343(2):248-257
Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier.
Yang S, Krug SM, Heitmann J, Hu L, Reinhold AK, Sauer S, Bosten J, Sommer C, Fromm M, Brack A, Rittner HL
Biomaterials 2016 Mar;82:20-33
Biomaterials 2016 Mar;82:20-33
Retinal Pigment Epithelium Atrophy 1 (rpea1): A New Mouse Model With Retinal Detachment Caused by a Disruption of Protein Kinase C, θ.
Ji X, Liu Y, Hurd R, Wang J, Fitzmaurice B, Nishina PM, Chang B
Investigative ophthalmology & visual science 2016 Mar;57(3):877-88
Investigative ophthalmology & visual science 2016 Mar;57(3):877-88
Increased expression of dermatopontin and its implications for testicular dysfunction in mice.
Cai J, Liu W, Hao J, Chen M, Li G
Molecular medicine reports 2016 Mar;13(3):2431-8
Molecular medicine reports 2016 Mar;13(3):2431-8
PCP Signaling between Migrating Neurons and their Planar-Polarized Neuroepithelial Environment Controls Filopodial Dynamics and Directional Migration.
Davey CF, Mathewson AW, Moens CB
PLoS genetics 2016 Mar;12(3):e1005934
PLoS genetics 2016 Mar;12(3):e1005934
Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation.
Shukla PK, Chaudhry KK, Mir H, Gangwar R, Yadav N, Manda B, Meena AS, Rao R
BMC cancer 2016 Mar 7;16:189
BMC cancer 2016 Mar 7;16:189
Specific deletion of AMP-activated protein kinase (α1AMPK) in mouse Sertoli cells modifies germ cell quality.
Bertoldo MJ, Guibert E, Faure M, Guillou F, Ramé C, Nadal-Desbarats L, Foretz M, Viollet B, Dupont J, Froment P
Molecular and cellular endocrinology 2016 Mar 5;423:96-112
Molecular and cellular endocrinology 2016 Mar 5;423:96-112
Acetylated bacterial cellulose coated with urinary bladder matrix as a substrate for retinal pigment epithelium.
Gonçalves S, Rodrigues IP, Padrão J, Silva JP, Sencadas V, Lanceros-Mendez S, Girão H, Gama FM, Dourado F, Rodrigues LR
Colloids and surfaces. B, Biointerfaces 2016 Mar 1;139:1-9
Colloids and surfaces. B, Biointerfaces 2016 Mar 1;139:1-9
293 cells express both epithelial as well as mesenchymal cell adhesion molecules.
Inada M, Izawa G, Kobayashi W, Ozawa M
International journal of molecular medicine 2016 Jun;37(6):1521-7
International journal of molecular medicine 2016 Jun;37(6):1521-7
MicroRNA-150 regulates blood-brain barrier permeability via Tie-2 after permanent middle cerebral artery occlusion in rats.
Fang Z, He QW, Li Q, Chen XL, Baral S, Jin HJ, Zhu YY, Li M, Xia YP, Mao L, Hu B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Jun;30(6):2097-107
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Jun;30(6):2097-107
Maternal Obesity in the Mouse Compromises the Blood-Brain Barrier in the Arcuate Nucleus of Offspring.
Kim DW, Glendining KA, Grattan DR, Jasoni CL
Endocrinology 2016 Jun;157(6):2229-42
Endocrinology 2016 Jun;157(6):2229-42
Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells.
Gao Y, Lui WY, Lee WM, Cheng CY
Scientific reports 2016 Jun 30;6:28589
Scientific reports 2016 Jun 30;6:28589
Alix-mediated assembly of the actomyosin-tight junction polarity complex preserves epithelial polarity and epithelial barrier.
Campos Y, Qiu X, Gomero E, Wakefield R, Horner L, Brutkowski W, Han YG, Solecki D, Frase S, Bongiovanni A, d'Azzo A
Nature communications 2016 Jun 23;7:11876
Nature communications 2016 Jun 23;7:11876
Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland.
Baker L, BeGora M, Au Yeung F, Feigin ME, Rosenberg AZ, Lowe SW, Kislinger T, Muthuswamy SK
Journal of cell science 2016 Jun 15;129(12):2307-15
Journal of cell science 2016 Jun 15;129(12):2307-15
Adropin reduces paracellular permeability of rat brain endothelial cells exposed to ischemia-like conditions.
Yang C, DeMars KM, Hawkins KE, Candelario-Jalil E
Peptides 2016 Jul;81:29-37
Peptides 2016 Jul;81:29-37
A novel in vitro platform for the study of SN38-induced mucosal damage and the development of Toll-like receptor 4-targeted therapeutic options.
Wardill HR, Gibson RJ, Van Sebille YZ, Secombe KR, Logan RM, Bowen JM
Experimental biology and medicine (Maywood, N.J.) 2016 Jul;241(13):1386-94
Experimental biology and medicine (Maywood, N.J.) 2016 Jul;241(13):1386-94
Reduced insulin secretion function is associated with pancreatic islet redistribution of cell adhesion molecules (CAMS) in diabetic mice after prolonged high-fat diet.
Falcão VT, Maschio DA, de Fontes CC, Oliveira RB, Santos-Silva JC, Almeida AC, Vanzela EC, Cartaxo MT, Carvalho CP, Collares-Buzato CB
Histochemistry and cell biology 2016 Jul;146(1):13-31
Histochemistry and cell biology 2016 Jul;146(1):13-31
Rescue of perfluorooctanesulfonate (PFOS)-mediated Sertoli cell injury by overexpression of gap junction protein connexin 43.
Li N, Mruk DD, Chen H, Wong CK, Lee WM, Cheng CY
Scientific reports 2016 Jul 20;6:29667
Scientific reports 2016 Jul 20;6:29667
C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms.
Priego N, Arechederra M, Sequera C, Bragado P, Vázquez-Carballo A, Gutiérrez-Uzquiza Á, Martín-Granado V, Ventura JJ, Kazanietz MG, Guerrero C, Porras A
Oncotarget 2016 Jul 19;7(29):45060-45078
Oncotarget 2016 Jul 19;7(29):45060-45078
Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier.
Lazarevic I, Engelhardt B
Fluids and barriers of the CNS 2016 Jan 29;13:2
Fluids and barriers of the CNS 2016 Jan 29;13:2
Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice.
Liu Y, Su X, Hao J, Chen M, Liu W, Liao X, Li G
International journal of molecular sciences 2016 Jan 13;17(1)
International journal of molecular sciences 2016 Jan 13;17(1)
The levels of epithelial anchor proteins β-catenin and zona occludens-1 are altered by E7 of human papillomaviruses 5 and 8.
Heuser S, Hufbauer M, Marx B, Tok A, Majewski S, Pfister H, Akgül B
The Journal of general virology 2016 Feb;97(2):463-472
The Journal of general virology 2016 Feb;97(2):463-472
A comparative study of epidermal tight junction proteins in a dog model of atopic dermatitis.
Kim HJ, Cronin M, Ahrens K, Papastavros V, Santoro D, Marsella R
Veterinary dermatology 2016 Feb;27(1):40-e11
Veterinary dermatology 2016 Feb;27(1):40-e11
Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection.
Nair VR, Franco LH, Zacharia VM, Khan HS, Stamm CE, You W, Marciano DK, Yagita H, Levine B, Shiloh MU
Cell reports 2016 Aug 2;16(5):1253-1258
Cell reports 2016 Aug 2;16(5):1253-1258
Gonadotropin suppression in men leads to a reduction in claudin-11 at the Sertoli cell tight junction.
McCabe MJ, Tarulli GA, Laven-Law G, Matthiesson KL, Meachem SJ, McLachlan RI, Dinger ME, Stanton PG
Human reproduction (Oxford, England) 2016 Apr;31(4):875-86
Human reproduction (Oxford, England) 2016 Apr;31(4):875-86
Connexin 43 reboots meiosis and reseals blood-testis barrier following toxicant-mediated aspermatogenesis and barrier disruption.
Li N, Mruk DD, Mok KW, Li MW, Wong CK, Lee WM, Han D, Silvestrini B, Cheng CY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Apr;30(4):1436-52
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Apr;30(4):1436-52
Tight junction defects are seen in the buccal mucosa of patients receiving standard dose chemotherapy for cancer.
Wardill HR, Logan RM, Bowen JM, Van Sebille YZ, Gibson RJ
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2016 Apr;24(4):1779-88
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2016 Apr;24(4):1779-88
Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo.
Gebala V, Collins R, Geudens I, Phng LK, Gerhardt H
Nature cell biology 2016 Apr;18(4):443-50
Nature cell biology 2016 Apr;18(4):443-50
Hematopoietic Stem Cells Transplantation Can Normalize Thyroid Function in a Cystinosis Mouse Model.
Gaide Chevronnay HP, Janssens V, Van Der Smissen P, Rocca CJ, Liao XH, Refetoff S, Pierreux CE, Cherqui S, Courtoy PJ
Endocrinology 2016 Apr;157(4):1363-71
Endocrinology 2016 Apr;157(4):1363-71
Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening.
Klinkert K, Rocancourt M, Houdusse A, Echard A
Nature communications 2016 Apr 4;7:11166
Nature communications 2016 Apr 4;7:11166
Generation and functional characterization of epithelial cells with stable expression of SLC26A9 Cl- channels.
Salomon JJ, Spahn S, Wang X, Füllekrug J, Bertrand CA, Mall MA
American journal of physiology. Lung cellular and molecular physiology 2016 Apr 1;310(7):L593-602
American journal of physiology. Lung cellular and molecular physiology 2016 Apr 1;310(7):L593-602
A Method for the Isolation and Culture of Adult Rat Retinal Pigment Epithelial (RPE) Cells to Study Retinal Diseases.
Heller JP, Kwok JC, Vecino E, Martin KR, Fawcett JW
Frontiers in cellular neuroscience 2015;9:449
Frontiers in cellular neuroscience 2015;9:449
A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions.
Sreekanthreddy P, Gromnicova R, Davies H, Phillips J, Romero IA, Male D
F1000Research 2015;4:1279
F1000Research 2015;4:1279
Methodologies for analysis of patterning in the mouse RPE sheet.
Boatright JH, Dalal N, Chrenek MA, Gardner C, Ziesel A, Jiang Y, Grossniklaus HE, Nickerson JM
Molecular vision 2015;21:40-60
Molecular vision 2015;21:40-60
A Triple Culture Model of the Blood-Brain Barrier Using Porcine Brain Endothelial cells, Astrocytes and Pericytes.
Thomsen LB, Burkhart A, Moos T
PloS one 2015;10(8):e0134765
PloS one 2015;10(8):e0134765
Lipopolysaccharide-induced middle ear inflammation disrupts the cochlear intra-strial fluid-blood barrier through down-regulation of tight junction proteins.
Zhang J, Chen S, Hou Z, Cai J, Dong M, Shi X
PloS one 2015;10(3):e0122572
PloS one 2015;10(3):e0122572
Actin-bundling protein plastin 3 is a regulator of ectoplasmic specialization dynamics during spermatogenesis in the rat testis.
Li N, Mruk DD, Wong CK, Lee WM, Han D, Cheng CY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Sep;29(9):3788-805
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Sep;29(9):3788-805
Development of a Bronchial Wall Model: Triple Culture on a Decellularized Porcine Trachea.
Melo E, Kasper JY, Unger RE, Farré R, Kirkpatrick CJ
Tissue engineering. Part C, Methods 2015 Sep;21(9):909-21
Tissue engineering. Part C, Methods 2015 Sep;21(9):909-21
ETB receptor-mediated MMP-9 activation induces vasogenic edema via ZO-1 protein degradation following status epilepticus.
Kim JY, Ko AR, Hyun HW, Kang TC
Neuroscience 2015 Sep 24;304:355-67
Neuroscience 2015 Sep 24;304:355-67
The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.
Pearson HB, McGlinn E, Phesse TJ, Schlüter H, Srikumar A, Gödde NJ, Woelwer CB, Ryan A, Phillips WA, Ernst M, Kaur P, Humbert P
Molecular cancer 2015 Sep 17;14:169
Molecular cancer 2015 Sep 17;14:169
Characterization of the equine blood-testis barrier during tubular development in normal and cryptorchid stallions.
Rode K, Sieme H, Richterich P, Brehm R
Theriogenology 2015 Sep 15;84(5):763-72
Theriogenology 2015 Sep 15;84(5):763-72
Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin.
Singh B, Bogatcheva G, Starchenko A, Sinnaeve J, Lapierre LA, Williams JA, Goldenring JR, Coffey RJ
Journal of cell science 2015 Sep 15;128(18):3444-55
Journal of cell science 2015 Sep 15;128(18):3444-55
Liver-Tumor Hybrid Organoids for Modeling Tumor Growth and Drug Response In Vitro.
Skardal A, Devarasetty M, Rodman C, Atala A, Soker S
Annals of biomedical engineering 2015 Oct;43(10):2361-73
Annals of biomedical engineering 2015 Oct;43(10):2361-73
HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model.
Suárez-Causado A, Caballero-Díaz D, Bertrán E, Roncero C, Addante A, García-Álvaro M, Fernández M, Herrera B, Porras A, Fabregat I, Sánchez A
Biochimica et biophysica acta 2015 Oct;1853(10 Pt A):2453-63
Biochimica et biophysica acta 2015 Oct;1853(10 Pt A):2453-63
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.
Priya R, Gomez GA, Budnar S, Verma S, Cox HL, Hamilton NA, Yap AS
Nature cell biology 2015 Oct;17(10):1282-93
Nature cell biology 2015 Oct;17(10):1282-93
Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization.
Bizet AA, Becker-Heck A, Ryan R, Weber K, Filhol E, Krug P, Halbritter J, Delous M, Lasbennes MC, Linghu B, Oakeley EJ, Zarhrate M, Nitschké P, Garfa-Traore M, Serluca F, Yang F, Bouwmeester T, Pinson L, Cassuto E, Dubot P, Elshakhs NAS, Sahel JA, Salomon R, Drummond IA, Gubler MC, Antignac C, Chibout S, Szustakowski JD, Hildebrandt F, Lorentzen E, Sailer AW, Benmerah A, Saint-Mezard P, Saunier S
Nature communications 2015 Oct 21;6:8666
Nature communications 2015 Oct 21;6:8666
A Rotating Bioreactor for Scalable Culture and Differentiation of Respiratory Epithelium.
Raredon MS, Ghaedi M, Calle EA, Niklason LE
Cell medicine 2015 Oct 1;7(3):109-21
Cell medicine 2015 Oct 1;7(3):109-21
Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis.
Sivaraj KK, Li R, Albarran-Juarez J, Wang S, Tischner D, Grimm M, Swiercz JM, Offermanns S, Wettschureck N
Cardiovascular research 2015 Oct 1;108(1):171-80
Cardiovascular research 2015 Oct 1;108(1):171-80
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.
Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, Nostro C, Wang R, Muthuswamy LB, Crawford HC, Arrowsmith C, Kalloger SE, Renouf DJ, Connor AA, Cleary S, Schaeffer DF, Roehrl M, Tsao MS, Gallinger S, Keller G, Muthuswamy SK
Nature medicine 2015 Nov;21(11):1364-71
Nature medicine 2015 Nov;21(11):1364-71
Injury to the blood-testis barrier after low-dose-rate chronic radiation exposure in mice.
Son Y, Heo K, Bae MJ, Lee CG, Cho WS, Kim SD, Yang K, Shin IS, Lee MY, Kim JS
Radiation protection dosimetry 2015 Nov;167(1-3):316-20
Radiation protection dosimetry 2015 Nov;167(1-3):316-20
Slc15a1 is involved in the transport of synthetic F5-peptide into the seminiferous epithelium in adult rat testes.
Su L, Zhang Y, Cheng YC, Lee WM, Ye K, Hu D
Scientific reports 2015 Nov 5;5:16271
Scientific reports 2015 Nov 5;5:16271
Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer's disease.
Bergen AA, Kaing S, ten Brink JB, Netherlands Brain Bank, Gorgels TG, Janssen SF
BMC genomics 2015 Nov 16;16:956
BMC genomics 2015 Nov 16;16:956
Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways.
Martínez-Revollar G, Garay E, Martin-Tapia D, Nava P, Huerta M, Lopez-Bayghen E, Meraz-Cruz N, Segovia J, González-Mariscal L
Experimental cell research 2015 Nov 15;339(1):67-80
Experimental cell research 2015 Nov 15;339(1):67-80
Short communication: Glucagon-like peptide-2 and coccidiosis alter tight junction gene expression in the gastrointestinal tract of dairy calves.
Walker MP, Evock-Clover CM, Elsasser TH, Connor EE
Journal of dairy science 2015 May;98(5):3432-7
Journal of dairy science 2015 May;98(5):3432-7
Brain barrier properties and cerebral blood flow in neonatal mice exposed to cerebral hypoxia-ischemia.
Ek CJ, D'Angelo B, Baburamani AA, Lehner C, Leverin AL, Smith PL, Nilsson H, Svedin P, Hagberg H, Mallard C
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2015 May;35(5):818-27
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2015 May;35(5):818-27
Alterations of intercellular junctions in peritoneal mesothelial cells from patients undergoing dialysis: effect of retinoic Acid.
Retana C, Sanchez E, Perez-Lopez A, Cruz A, Lagunas J, Cruz C, Vital S, Reyes JL
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2015 May-Jun;35(3):275-87
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2015 May-Jun;35(3):275-87
Musashi-1 maintains blood-testis barrier structure during spermatogenesis and regulates stress granule formation upon heat stress.
ErLin S, WenJie W, LiNing W, BingXin L, MingDe L, Yan S, RuiFa H
Molecular biology of the cell 2015 May 15;26(10):1947-56
Molecular biology of the cell 2015 May 15;26(10):1947-56
MTH1 expression is required for effective transformation by oncogenic HRAS.
Giribaldi MG, Munoz A, Halvorsen K, Patel A, Rai P
Oncotarget 2015 May 10;6(13):11519-29
Oncotarget 2015 May 10;6(13):11519-29
Neural crest specification by inhibition of the ROCK/Myosin II pathway.
Kim K, Ossipova O, Sokol SY
Stem cells (Dayton, Ohio) 2015 Mar;33(3):674-85
Stem cells (Dayton, Ohio) 2015 Mar;33(3):674-85
Biophysical characterization of interactions between the C-termini of peripheral nerve claudins and the PDZ₁ domain of zonula occludens.
Wu J, Peng D, Zhang Y, Lu Z, Voehler M, Sanders CR, Li J
Biochemical and biophysical research communications 2015 Mar 27;459(1):87-93
Biochemical and biophysical research communications 2015 Mar 27;459(1):87-93
Vessel maturation schedule determines vulnerability to neuronal injuries of prematurity.
Licht T, Dor-Wollman T, Ben-Zvi A, Rothe G, Keshet E
The Journal of clinical investigation 2015 Mar 2;125(3):1319-28
The Journal of clinical investigation 2015 Mar 2;125(3):1319-28
Design and validation of a clinical-scale bioreactor for long-term isolated lung culture.
Charest JM, Okamoto T, Kitano K, Yasuda A, Gilpin SE, Mathisen DJ, Ott HC
Biomaterials 2015 Jun;52:79-87
Biomaterials 2015 Jun;52:79-87
TRPV4 regulates the integrity of the blood-cerebrospinal fluid barrier and modulates transepithelial protein transport.
Narita K, Sasamoto S, Koizumi S, Okazaki S, Nakamura H, Inoue T, Takeda S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Jun;29(6):2247-59
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Jun;29(6):2247-59
Bacterial induction of Snail1 contributes to blood-brain barrier disruption.
Kim BJ, Hancock BM, Bermudez A, Del Cid N, Reyes E, van Sorge NM, Lauth X, Smurthwaite CA, Hilton BJ, Stotland A, Banerjee A, Buchanan J, Wolkowicz R, Traver D, Doran KS
The Journal of clinical investigation 2015 Jun;125(6):2473-83
The Journal of clinical investigation 2015 Jun;125(6):2473-83
Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.
Chang CJ, Lin CS, Lu CC, Martel J, Ko YF, Ojcius DM, Tseng SF, Wu TR, Chen YY, Young JD, Lai HC
Nature communications 2015 Jun 23;6:7489
Nature communications 2015 Jun 23;6:7489
Dexamethasone potentiates in vitro blood-brain barrier recovery after primary blast injury by glucocorticoid receptor-mediated upregulation of ZO-1 tight junction protein.
Hue CD, Cho FS, Cao S, Dale Bass CR, Meaney DF, Morrison B 3rd
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2015 Jul;35(7):1191-8
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2015 Jul;35(7):1191-8
TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways.
Freeman JJ, Feng Y, Demehri FR, Dempsey PJ, Teitelbaum DH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Jul;29(7):2943-58
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Jul;29(7):2943-58
Barrier Function of the Repaired Skin Is Disrupted Following Arrest of Dicer in Keratinocytes.
Ghatak S, Chan YC, Khanna S, Banerjee J, Weist J, Roy S, Sen CK
Molecular therapy : the journal of the American Society of Gene Therapy 2015 Jul;23(7):1201-1210
Molecular therapy : the journal of the American Society of Gene Therapy 2015 Jul;23(7):1201-1210
MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell-cell junctions in epithelial cells.
Breznau EB, Semack AC, Higashi T, Miller AL
Molecular biology of the cell 2015 Jul 1;26(13):2439-55
Molecular biology of the cell 2015 Jul 1;26(13):2439-55
Roundabout 4 regulates blood-tumor barrier permeability through the modulation of ZO-1, Occludin, and Claudin-5 expression.
Cai H, Liu W, Xue Y, Shang X, Liu J, Li Z, Wang P, Liu L, Hu Y, Liu Y
Journal of neuropathology and experimental neurology 2015 Jan;74(1):25-37
Journal of neuropathology and experimental neurology 2015 Jan;74(1):25-37
EGF regulates claudin-2 and -4 expression through Src and STAT3 in MDCK cells.
García-Hernández V, Flores-Maldonado C, Rincon-Heredia R, Verdejo-Torres O, Bonilla-Delgado J, Meneses-Morales I, Gariglio P, Contreras RG
Journal of cellular physiology 2015 Jan;230(1):105-15
Journal of cellular physiology 2015 Jan;230(1):105-15
Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.
Park DS, Cerrone M, Morley G, Vasquez C, Fowler S, Liu N, Bernstein SA, Liu FY, Zhang J, Rogers CS, Priori SG, Chinitz LA, Fishman GI
The Journal of clinical investigation 2015 Jan;125(1):403-12
The Journal of clinical investigation 2015 Jan;125(1):403-12
Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery.
Casselbrant A, Elias E, Fändriks L, Wallenius V
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2015 Jan-Feb;11(1):45-53
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2015 Jan-Feb;11(1):45-53
An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation.
Suzuki T, Kono T, Bochimoto H, Hira Y, Watanabe T, Furukawa H
Scientific reports 2015 Jan 8;5:7668
Scientific reports 2015 Jan 8;5:7668
Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling.
Kapodistria K, Tsilibary EP, Politis P, Moustardas P, Charonis A, Kitsiou P
Molecular and cellular endocrinology 2015 Jan 15;400:112-28
Molecular and cellular endocrinology 2015 Jan 15;400:112-28
EB1 regulates tubulin and actin cytoskeletal networks at the sertoli cell blood-testis barrier in male rats: an in vitro study.
Tang EI, Mok KW, Lee WM, Cheng CY
Endocrinology 2015 Feb;156(2):680-93
Endocrinology 2015 Feb;156(2):680-93
Generation of highly enriched populations of optic vesicle-like retinal cells from human pluripotent stem cells.
Ohlemacher SK, Iglesias CL, Sridhar A, Gamm DM, Meyer JS
Current protocols in stem cell biology 2015 Feb 2;32:1H.8.1-1H.8.20
Current protocols in stem cell biology 2015 Feb 2;32:1H.8.1-1H.8.20
Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin.
Zhao YY, Zhao LN, Wang P, Miao YS, Liu YH, Wang ZH, Ma J, Li Z, Li ZQ, Xue YX
Journal of neuroscience research 2015 Dec;93(12):1891-902
Journal of neuroscience research 2015 Dec;93(12):1891-902
Effects of low-level laser irradiation on proliferation and functional protein expression in human RPE cells.
Dang Y, Wu W, Xu Y, Mu Y, Xu K, Wu H, Zhu Y, Zhang C
Lasers in medical science 2015 Dec;30(9):2295-302
Lasers in medical science 2015 Dec;30(9):2295-302
Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke.
Frankowski JC, DeMars KM, Ahmad AS, Hawkins KE, Yang C, Leclerc JL, Doré S, Candelario-Jalil E
Scientific reports 2015 Dec 9;5:17956
Scientific reports 2015 Dec 9;5:17956
Identification of CCL2, RARRES2 and EFNB2 as host cell factors that influence the multistep replication of respiratory syncytial virus.
Shirato K, Ujike M, Kawase M, Matsuyama S
Virus research 2015 Dec 2;210:213-26
Virus research 2015 Dec 2;210:213-26
Abnormalities in Expression of Structural, Barrier and Differentiation Related Proteins, and Chondroitin Sulfate in Feline and Human Interstitial Cystitis.
Hauser PJ, VanGordon SB, Seavey J, Sofinowski TM, Ramadan M, Abdullah S, Buffington CA, Hurst RE
The Journal of urology 2015 Aug;194(2):571-7
The Journal of urology 2015 Aug;194(2):571-7
Transfection of brain capillary endothelial cells in primary culture with defined blood-brain barrier properties.
Burkhart A, Thomsen LB, Thomsen MS, Lichota J, Fazakas C, Krizbai I, Moos T
Fluids and barriers of the CNS 2015 Aug 7;12:19
Fluids and barriers of the CNS 2015 Aug 7;12:19
Expression of tight junction proteins and transporters for xenobiotic metabolism at the blood-CSF barrier during development in the nonhuman primate (P. hamadryas).
Ek CJ, D'Angelo B, Lehner C, Nathanielsz P, Li C, Mallard C
Reproductive toxicology (Elmsford, N.Y.) 2015 Aug 15;56:32-44
Reproductive toxicology (Elmsford, N.Y.) 2015 Aug 15;56:32-44
The long noncoding RNA TUG1 regulates blood-tumor barrier permeability by targeting miR-144.
Cai H, Xue Y, Wang P, Wang Z, Li Z, Hu Y, Li Z, Shang X, Liu Y
Oncotarget 2015 Aug 14;6(23):19759-79
Oncotarget 2015 Aug 14;6(23):19759-79
JNK-dependent gene regulatory circuitry governs mesenchymal fate.
Sahu SK, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, Ortega F, Schmarowski N, Berninger B, Nitsch R, Schmidt M, Tiwari VK
The EMBO journal 2015 Aug 13;34(16):2162-81
The EMBO journal 2015 Aug 13;34(16):2162-81
Paclitaxel-induced lung injury and its amelioration by parecoxib sodium.
Liu WJ, Zhong ZJ, Cao LH, Li HT, Zhang TH, Lin WQ
Scientific reports 2015 Aug 10;5:12977
Scientific reports 2015 Aug 10;5:12977
Increasing fat content from 20 to 45 wt% in a complex diet induces lower endotoxemia in parallel with an increased number of intestinal goblet cells in mice.
Benoit B, Laugerette F, Plaisancié P, Géloën A, Bodennec J, Estienne M, Pineau G, Bernalier-Donadille A, Vidal H, Michalski MC
Nutrition research (New York, N.Y.) 2015 Apr;35(4):346-56
Nutrition research (New York, N.Y.) 2015 Apr;35(4):346-56
Control of cell-cell forces and collective cell dynamics by the intercellular adhesome.
Bazellières E, Conte V, Elosegui-Artola A, Serra-Picamal X, Bintanel-Morcillo M, Roca-Cusachs P, Muñoz JJ, Sales-Pardo M, Guimerà R, Trepat X
Nature cell biology 2015 Apr;17(4):409-20
Nature cell biology 2015 Apr;17(4):409-20
Increased gut permeability and bacterial translocation after chronic chlorpyrifos exposure in rats.
Joly Condette C, Khorsi-Cauet H, Morlière P, Zabijak L, Reygner J, Bach V, Gay-Quéheillard J
PloS one 2014;9(7):e102217
PloS one 2014;9(7):e102217
Berberine protects against neuronal damage via suppression of glia-mediated inflammation in traumatic brain injury.
Chen CC, Hung TH, Lee CY, Wang LF, Wu CH, Ke CH, Chen SF
PloS one 2014;9(12):e115694
PloS one 2014;9(12):e115694
Loss of EP2 receptor subtype in colonic cells compromise epithelial barrier integrity by altering claudin-4.
Lejeune M, Moreau F, Chadee K
PloS one 2014;9(11):e113270
PloS one 2014;9(11):e113270
Autonomous stimulation of cancer cell plasticity by the human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells.
Cai X, Dai Z, Reeves RS, Caballero-Benitez A, Duran KL, Delrow JJ, Porter PL, Spies T, Groh V
PloS one 2014;9(10):e108942
PloS one 2014;9(10):e108942
The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress.
Chang YC, Chang WC, Hung KH, Yang DM, Cheng YH, Liao YW, Woung LC, Tsai CY, Hsu CC, Lin TC, Liu JH, Chiou SH, Peng CH, Chen SJ
Frontiers in aging neuroscience 2014;6:191
Frontiers in aging neuroscience 2014;6:191
Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina.
de Andrade GB, Kunzelman L, Merrill MM, Fuerst PG
Molecular vision 2014;20:1422-33
Molecular vision 2014;20:1422-33
Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion.
Qiao X, Roth I, Féraille E, Hasler U
Cell cycle (Georgetown, Tex.) 2014;13(19):3059-75
Cell cycle (Georgetown, Tex.) 2014;13(19):3059-75
A neurovascular blood-brain barrier in vitro model.
Zehendner CM, White R, Hedrich J, Luhmann HJ
Methods in molecular biology (Clifton, N.J.) 2014;1135:403-13
Methods in molecular biology (Clifton, N.J.) 2014;1135:403-13
In-depth characterisation of Retinal Pigment Epithelium (RPE) cells derived from human induced pluripotent stem cells (hiPSC).
Brandl C, Zimmermann SJ, Milenkovic VM, Rosendahl SM, Grassmann F, Milenkovic A, Hehr U, Federlin M, Wetzel CH, Helbig H, Weber BH
Neuromolecular medicine 2014 Sep;16(3):551-64
Neuromolecular medicine 2014 Sep;16(3):551-64
Bleeding propensity of cavernous malformations: impact of tight junction alterations on the occurrence of overt hematoma.
Jakimovski D, Schneider H, Frei K, Kennes LN, Bertalanffy H
Journal of neurosurgery 2014 Sep;121(3):613-20
Journal of neurosurgery 2014 Sep;121(3):613-20
Myosin Vb mediated plasma membrane homeostasis regulates peridermal cell size and maintains tissue homeostasis in the zebrafish epidermis.
Sonal, Sidhaye J, Phatak M, Banerjee S, Mulay A, Deshpande O, Bhide S, Jacob T, Gehring I, Nuesslein-Volhard C, Sonawane M
PLoS genetics 2014 Sep;10(9):e1004614
PLoS genetics 2014 Sep;10(9):e1004614
FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis.
Petridou NI, Skourides PA
Nature communications 2014 Oct 24;5:5240
Nature communications 2014 Oct 24;5:5240
The angiopoietin1-Akt pathway regulates barrier function of the cultured spinal cord microvascular endothelial cells through Eps8.
Liu X, Zhou X, Yuan W
Experimental cell research 2014 Oct 15;328(1):118-131
Experimental cell research 2014 Oct 15;328(1):118-131
Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst.
Kono K, Tamashiro DA, Alarcon VB
Developmental biology 2014 Oct 1;394(1):142-55
Developmental biology 2014 Oct 1;394(1):142-55
A PKA-ezrin-Cx43 signaling complex controls gap junction communication and thereby trophoblast cell fusion.
Pidoux G, Gerbaud P, Dompierre J, Lygren B, Solstad T, Evain-Brion D, Taskén K
Journal of cell science 2014 Oct 1;127(Pt 19):4172-85
Journal of cell science 2014 Oct 1;127(Pt 19):4172-85
The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells.
Xia Y, Sancho-Martinez I, Nivet E, Rodriguez Esteban C, Campistol JM, Izpisua Belmonte JC
Nature protocols 2014 Nov;9(11):2693-704
Nature protocols 2014 Nov;9(11):2693-704
Long-term ketamine abuse induces cystitis in rats by impairing the bladder epithelial barrier.
Gu D, Huang J, Yin Y, Shan Z, Zheng S, Wu P
Molecular biology reports 2014 Nov;41(11):7313-22
Molecular biology reports 2014 Nov;41(11):7313-22
The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions.
Steiner E, Enzmann GU, Lyck R, Lin S, Rüegg MA, Kröger S, Engelhardt B
Cell and tissue research 2014 Nov;358(2):465-79
Cell and tissue research 2014 Nov;358(2):465-79
Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice.
Yoshida T, Iwata T, Takai Y, Birchmeier W, Yamato M, Okano T
Genes to cells : devoted to molecular & cellular mechanisms 2014 Nov;19(11):842-52
Genes to cells : devoted to molecular & cellular mechanisms 2014 Nov;19(11):842-52
The RAB5-GEF function of RIN1 regulates multiple steps during Listeria monocytogenes infection.
Balaji K, French CT, Miller JF, Colicelli J
Traffic (Copenhagen, Denmark) 2014 Nov;15(11):1206-18
Traffic (Copenhagen, Denmark) 2014 Nov;15(11):1206-18
The gut microbiota influences blood-brain barrier permeability in mice.
Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Tóth M, Korecka A, Bakocevic N, Ng LG, Kundu P, Gulyás B, Halldin C, Hultenby K, Nilsson H, Hebert H, Volpe BT, Diamond B, Pettersson S
Science translational medicine 2014 Nov 19;6(263):263ra158
Science translational medicine 2014 Nov 19;6(263):263ra158
rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9.
Mok KW, Mruk DD, Cheng CY
Journal of cell science 2014 Nov 15;127(Pt 22):4870-82
Journal of cell science 2014 Nov 15;127(Pt 22):4870-82
Fascin 1 is an actin filament-bundling protein that regulates ectoplasmic specialization dynamics in the rat testis.
Gungor-Ordueri NE, Celik-Ozenci C, Cheng CY
American journal of physiology. Endocrinology and metabolism 2014 Nov 1;307(9):E738-53
American journal of physiology. Endocrinology and metabolism 2014 Nov 1;307(9):E738-53
Electrical synaptic transmission in developing zebrafish: properties and molecular composition of gap junctions at a central auditory synapse.
Yao C, Vanderpool KG, Delfiner M, Eddy V, Lucaci AG, Soto-Riveros C, Yasumura T, Rash JE, Pereda AE
Journal of neurophysiology 2014 Nov 1;112(9):2102-13
Journal of neurophysiology 2014 Nov 1;112(9):2102-13
Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition.
Xiao W, Feng Y, Holst JJ, Hartmann B, Yang H, Teitelbaum DH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 May;28(5):2073-87
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 May;28(5):2073-87
Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer.
Li C, Ma H, Wang Y, Cao Z, Graves-Deal R, Powell AE, Starchenko A, Ayers GD, Washington MK, Kamath V, Desai K, Gerdes MJ, Solnica-Krezel L, Coffey RJ
The Journal of clinical investigation 2014 May;124(5):2172-87
The Journal of clinical investigation 2014 May;124(5):2172-87
Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.
Ikari A, Tonegawa C, Sanada A, Kimura T, Sakai H, Hayashi H, Hasegawa H, Yamaguchi M, Yamazaki Y, Endo S, Matsunaga T, Sugatani J
The Journal of biological chemistry 2014 May 9;289(19):13112-23
The Journal of biological chemistry 2014 May 9;289(19):13112-23
A plasminogen activator inhibitor type 1 mutant retards diabetic nephropathy in db/db mice by protecting podocytes.
Zhang J, Gu C, Lawrence DA, Cheung AK, Huang Y
Experimental physiology 2014 May 1;99(5):802-15
Experimental physiology 2014 May 1;99(5):802-15
LIM-homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF-B signaling.
Kuzmanov A, Hopfer U, Marti P, Meyer-Schaller N, Yilmaz M, Christofori G
Molecular oncology 2014 Mar;8(2):401-16
Molecular oncology 2014 Mar;8(2):401-16
Lipopolysaccharide precipitates hepatic encephalopathy and increases blood-brain barrier permeability in mice with acute liver failure.
Chastre A, Bélanger M, Nguyen BN, Butterworth RF
Liver international : official journal of the International Association for the Study of the Liver 2014 Mar;34(3):353-61
Liver international : official journal of the International Association for the Study of the Liver 2014 Mar;34(3):353-61
Chorioamnionitis-induced fetal gut injury is mediated by direct gut exposure of inflammatory mediators or by lung inflammation.
Wolfs TG, Kramer BW, Thuijls G, Kemp MW, Saito M, Willems MG, Senthamarai-Kannan P, Newnham JP, Jobe AH, Kallapur SG
American journal of physiology. Gastrointestinal and liver physiology 2014 Mar 1;306(5):G382-93
American journal of physiology. Gastrointestinal and liver physiology 2014 Mar 1;306(5):G382-93
Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins.
Xiao X, Mruk DD, Tang EI, Wong CK, Lee WM, John CM, Turek PJ, Silvestrini B, Cheng CY
Human reproduction (Oxford, England) 2014 Jun;29(6):1279-91
Human reproduction (Oxford, England) 2014 Jun;29(6):1279-91
Inhibition of PKC-θ preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy.
Li Z, Abdullah CS, Jin ZQ
British journal of pharmacology 2014 Jun;171(11):2913-24
British journal of pharmacology 2014 Jun;171(11):2913-24
Anillin regulates cell-cell junction integrity by organizing junctional accumulation of Rho-GTP and actomyosin.
Reyes CC, Jin M, Breznau EB, Espino R, Delgado-Gonzalo R, Goryachev AB, Miller AL
Current biology : CB 2014 Jun 2;24(11):1263-70
Current biology : CB 2014 Jun 2;24(11):1263-70
IL-1β and TGF-β weaken the placental barrier through destruction of tight junctions: an in vivo and in vitro study.
Tossetta G, Paolinelli F, Avellini C, Salvolini E, Ciarmela P, Lorenzi T, Emanuelli M, Toti P, Giuliante R, Gesuita R, Crescimanno C, Voltolini C, Di Primio R, Petraglia F, Castellucci M, Marzioni D
Placenta 2014 Jul;35(7):509-16
Placenta 2014 Jul;35(7):509-16
E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition.
Chen A, Beetham H, Black MA, Priya R, Telford BJ, Guest J, Wiggins GA, Godwin TD, Yap AS, Guilford PJ
BMC cancer 2014 Jul 30;14:552
BMC cancer 2014 Jul 30;14:552
Perfluorooctanesulfonate (PFOS) perturbs male rat Sertoli cell blood-testis barrier function by affecting F-actin organization via p-FAK-Tyr(407): an in vitro study.
Wan HT, Mruk DD, Wong CK, Cheng CY
Endocrinology 2014 Jan;155(1):249-62
Endocrinology 2014 Jan;155(1):249-62
β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier.
Gorina R, Lyck R, Vestweber D, Engelhardt B
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 1;192(1):324-37
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 1;192(1):324-37
Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets.
Balko JM, Giltnane JM, Wang K, Schwarz LJ, Young CD, Cook RS, Owens P, Sanders ME, Kuba MG, Sánchez V, Kurupi R, Moore PD, Pinto JA, Doimi FD, Gómez H, Horiuchi D, Goga A, Lehmann BD, Bauer JA, Pietenpol JA, Ross JS, Palmer GA, Yelensky R, Cronin M, Miller VA, Stephens PJ, Arteaga CL
Cancer discovery 2014 Feb;4(2):232-45
Cancer discovery 2014 Feb;4(2):232-45
Intraluminal acid activates esophageal nodose C fibers after mast cell activation.
Zhang S, Liu Z, Heldsinger A, Owyang C, Yu S
American journal of physiology. Gastrointestinal and liver physiology 2014 Feb;306(3):G200-7
American journal of physiology. Gastrointestinal and liver physiology 2014 Feb;306(3):G200-7
Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens.
Caldwell BJ, Lucas C, Kee AJ, Gaus K, Gunning PW, Hardeman EC, Yap AS, Gomez GA
Cytoskeleton (Hoboken, N.J.) 2014 Dec;71(12):663-76
Cytoskeleton (Hoboken, N.J.) 2014 Dec;71(12):663-76
Amelioration of hypoxia and LPS-induced intestinal epithelial barrier dysfunction by emodin through the suppression of the NF-κB and HIF-1α signaling pathways.
Lei Q, Qiang F, Chao D, Di W, Guoqian Z, Bo Y, Lina Y
International journal of molecular medicine 2014 Dec;34(6):1629-39
International journal of molecular medicine 2014 Dec;34(6):1629-39
PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.
Wu CY, Carpenter ES, Takeuchi KK, Halbrook CJ, Peverley LV, Bien H, Hall JC, DelGiorno KE, Pal D, Song Y, Shi C, Lin RZ, Crawford HC
Gastroenterology 2014 Dec;147(6):1405-16.e7
Gastroenterology 2014 Dec;147(6):1405-16.e7
Estrogen receptor alpha deficiency protects against development of cognitive impairment in murine lupus.
Cunningham MA, Wirth JR, Freeman LR, Boger HA, Granholm AC, Gilkeson GS
Journal of neuroinflammation 2014 Dec 16;11:171
Journal of neuroinflammation 2014 Dec 16;11:171
ZO proteins redundantly regulate the transcription factor DbpA/ZONAB.
Spadaro D, Tapia R, Jond L, Sudol M, Fanning AS, Citi S
The Journal of biological chemistry 2014 Aug 8;289(32):22500-11
The Journal of biological chemistry 2014 Aug 8;289(32):22500-11
Radial intercalation is regulated by the Par complex and the microtubule-stabilizing protein CLAMP/Spef1.
Werner ME, Mitchell JW, Putzbach W, Bacon E, Kim SK, Mitchell BJ
The Journal of cell biology 2014 Aug 4;206(3):367-76
The Journal of cell biology 2014 Aug 4;206(3):367-76
Pasture v. standard dairy cream in high-fat diet-fed mice: improved metabolic outcomes and stronger intestinal barrier.
Benoit B, Plaisancié P, Géloën A, Estienne M, Debard C, Meugnier E, Loizon E, Daira P, Bodennec J, Cousin O, Vidal H, Laugerette F, Michalski MC
The British journal of nutrition 2014 Aug 28;112(4):520-35
The British journal of nutrition 2014 Aug 28;112(4):520-35
Effect of retinoic acid on the tight junctions of the retinal pigment epithelium-choroid complex of guinea pigs with lens-induced myopia in vivo.
Wang S, Liu S, Mao J, Wen D
International journal of molecular medicine 2014 Apr;33(4):825-32
International journal of molecular medicine 2014 Apr;33(4):825-32
Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke.
Hawkins KE, DeMars KM, Singh J, Yang C, Cho HS, Frankowski JC, Doré S, Candelario-Jalil E
Journal of neurochemistry 2014 Apr;129(1):130-42
Journal of neurochemistry 2014 Apr;129(1):130-42
Novel human renal proximal tubular cell line for the production of complex proteins.
Fliedl L, Manhart G, Kast F, Katinger H, Kunert R, Grillari J, Wieser M, Grillari-Voglauer R
Journal of biotechnology 2014 Apr 20;176:29-39
Journal of biotechnology 2014 Apr 20;176:29-39
Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea.
Kawakami-Schulz SV, Verdoni AM, Sattler SG, Jessen E, Kao WW, Ikeda A, Ikeda S
Physiological genomics 2014 Apr 15;46(8):277-89
Physiological genomics 2014 Apr 15;46(8):277-89
Clostridium difficile toxins facilitate bacterial colonization by modulating the fence and gate function of colonic epithelium.
Kasendra M, Barrile R, Leuzzi R, Soriani M
The Journal of infectious diseases 2014 Apr 1;209(7):1095-104
The Journal of infectious diseases 2014 Apr 1;209(7):1095-104
Rai14 (retinoic acid induced protein 14) is involved in regulating f-actin dynamics at the ectoplasmic specialization in the rat testis*.
Qian X, Mruk DD, Cheng CY
PloS one 2013;8(4):e60656
PloS one 2013;8(4):e60656
The transcription factors Tbx18 and Wt1 control the epicardial epithelial-mesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cells.
Takeichi M, Nimura K, Mori M, Nakagami H, Kaneda Y
PloS one 2013;8(2):e57829
PloS one 2013;8(2):e57829
Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8).
Tiwari N, Meyer-Schaller N, Arnold P, Antoniadis H, Pachkov M, van Nimwegen E, Christofori G
PloS one 2013;8(2):e57329
PloS one 2013;8(2):e57329
The development of nasal polyp disease involves early nasal mucosal inflammation and remodelling.
Meng J, Zhou P, Liu Y, Liu F, Yi X, Liu S, Holtappels G, Bachert C, Zhang N
PloS one 2013;8(12):e82373
PloS one 2013;8(12):e82373
The reversible increase in tight junction permeability induced by capsaicin is mediated via cofilin-actin cytoskeletal dynamics and decreased level of occludin.
Shiobara T, Usui T, Han J, Isoda H, Nagumo Y
PloS one 2013;8(11):e79954
PloS one 2013;8(11):e79954
The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells.
Sugimoto K, Ichikawa-Tomikawa N, Satohisa S, Akashi Y, Kanai R, Saito T, Sawada N, Chiba H
PloS one 2013;8(10):e75106
PloS one 2013;8(10):e75106
The role of CDX2 in Caco-2 cell differentiation.
Natoli M, Christensen J, El-Gebali S, Felsani A, Anderle P
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2013 Sep;85(1):20-5
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2013 Sep;85(1):20-5
Perivascular macrophage-like melanocyte responsiveness to acoustic trauma--a salient feature of strial barrier associated hearing loss.
Zhang F, Dai M, Neng L, Zhang JH, Zhi Z, Fridberger A, Shi X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Sep;27(9):3730-40
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Sep;27(9):3730-40
Retinoic acid promotes Sertoli cell differentiation and antagonises activin-induced proliferation.
Nicholls PK, Harrison CA, Rainczuk KE, Wayne Vogl A, Stanton PG
Molecular and cellular endocrinology 2013 Sep 5;377(1-2):33-43
Molecular and cellular endocrinology 2013 Sep 5;377(1-2):33-43
E-cadherin supports steady-state Rho signaling at the epithelial zonula adherens.
Priya R, Yap AS, Gomez GA
Differentiation; research in biological diversity 2013 Oct;86(3):133-40
Differentiation; research in biological diversity 2013 Oct;86(3):133-40
Prevention of rt-PA induced blood-brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice.
Teng F, Beray-Berthat V, Coqueran B, Lesbats C, Kuntz M, Palmier B, Garraud M, Bedfert C, Slane N, Bérézowski V, Szeremeta F, Hachani J, Scherman D, Plotkine M, Doan BT, Marchand-Leroux C, Margaill I
Experimental neurology 2013 Oct;248:416-28
Experimental neurology 2013 Oct;248:416-28
A new human primary epithelial cell culture model to study conjunctival inflammation.
García-Posadas L, Arranz-Valsero I, López-García A, Soriano-Romaní L, Diebold Y
Investigative ophthalmology & visual science 2013 Oct 29;54(10):7143-52
Investigative ophthalmology & visual science 2013 Oct 29;54(10):7143-52
Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain.
Langlet F, Mullier A, Bouret SG, Prevot V, Dehouck B
The Journal of comparative neurology 2013 Oct 15;521(15):3389-405
The Journal of comparative neurology 2013 Oct 15;521(15):3389-405
Functional principal component analysis reveals discriminating categories of retinal pigment epithelial morphology in mice.
Jiang Y, Qi X, Chrenek MA, Gardner C, Boatright JH, Grossniklaus HE, Nickerson JM
Investigative ophthalmology & visual science 2013 Nov 5;54(12):7274-83
Investigative ophthalmology & visual science 2013 Nov 5;54(12):7274-83
A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth.
Marchion DC, Bicaku E, Xiong Y, Bou Zgheib N, Al Sawah E, Stickles XB, Judson PL, Lopez AS, Cubitt CL, Gonzalez-Bosquet J, Wenham RM, Apte SM, Berglund A, Lancaster JM
Oncology reports 2013 May;29(5):2011-8
Oncology reports 2013 May;29(5):2011-8
An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice.
Pitetti JL, Calvel P, Zimmermann C, Conne B, Papaioannou MD, Aubry F, Cederroth CR, Urner F, Fumel B, Crausaz M, Docquier M, Herrera PL, Pralong F, Germond M, Guillou F, Jégou B, Nef S
Molecular endocrinology (Baltimore, Md.) 2013 May;27(5):814-27
Molecular endocrinology (Baltimore, Md.) 2013 May;27(5):814-27
Palladin is a regulator of actin filament bundles at the ectoplasmic specialization in adult rat testes.
Qian X, Mruk DD, Wong EW, Lie PP, Cheng CY
Endocrinology 2013 May;154(5):1907-20
Endocrinology 2013 May;154(5):1907-20
Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state.
Lim YY, Wright JA, Attema JL, Gregory PA, Bert AG, Smith E, Thomas D, Lopez AF, Drew PA, Khew-Goodall Y, Goodall GJ
Journal of cell science 2013 May 15;126(Pt 10):2256-66
Journal of cell science 2013 May 15;126(Pt 10):2256-66
Rab25 regulates integrin expression in polarized colonic epithelial cells.
Krishnan M, Lapierre LA, Knowles BC, Goldenring JR
Molecular biology of the cell 2013 Mar;24(6):818-31
Molecular biology of the cell 2013 Mar;24(6):818-31
Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice.
Kissoon-Singh V, Moreau F, Trusevych E, Chadee K
The American journal of pathology 2013 Mar;182(3):852-65
The American journal of pathology 2013 Mar;182(3):852-65
PAR2-induced inflammatory responses in human kidney tubular epithelial cells.
Vesey DA, Suen JY, Seow V, Lohman RJ, Liu L, Gobe GC, Johnson DW, Fairlie DP
American journal of physiology. Renal physiology 2013 Mar 15;304(6):F737-50
American journal of physiology. Renal physiology 2013 Mar 15;304(6):F737-50
Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium.[corrected].
Gao X, Vockley CM, Pauli F, Newberry KM, Xue Y, Randell SH, Reddy TE, Hogan BL
Proceedings of the National Academy of Sciences of the United States of America 2013 Jun 4;110(23):9356-61
Proceedings of the National Academy of Sciences of the United States of America 2013 Jun 4;110(23):9356-61
Electromagnetic-pulse-induced activation of p38 MAPK pathway and disruption of blood-retinal barrier.
Li HJ, Guo LM, Yang LL, Zhou YC, Zhang YJ, Guo J, Xie XJ, Guo GZ
Toxicology letters 2013 Jun 20;220(1):35-43
Toxicology letters 2013 Jun 20;220(1):35-43
Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF.
Vandenbroucke RE, Dejonckheere E, Van Hauwermeiren F, Lodens S, De Rycke R, Van Wonterghem E, Staes A, Gevaert K, López-Otin C, Libert C
EMBO molecular medicine 2013 Jul;5(7):1000-16
EMBO molecular medicine 2013 Jul;5(7):1000-16
LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation.
Xu X, Jin D, Durgan J, Hall A
Molecular and cellular biology 2013 Jul;33(14):2671-82
Molecular and cellular biology 2013 Jul;33(14):2671-82
Breast cancer resistance protein (Bcrp) and the testis--an unexpected turn of events.
Qian X, Cheng YH, Mruk DD, Cheng CY
Asian journal of andrology 2013 Jul;15(4):455-60
Asian journal of andrology 2013 Jul;15(4):455-60
Ameliorative effect of PACAP and VIP against increased permeability in a model of outer blood retinal barrier dysfunction.
Scuderi S, D'Amico AG, Castorina A, Imbesi R, Carnazza ML, D'Agata V
Peptides 2013 Jan;39:119-24
Peptides 2013 Jan;39:119-24
c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution.
Xiao X, Mruk DD, Cheng CY
American journal of physiology. Endocrinology and metabolism 2013 Jan 15;304(2):E145-59
American journal of physiology. Endocrinology and metabolism 2013 Jan 15;304(2):E145-59
Zona occludens-2 protects against podocyte dysfunction induced by ADR in mice.
Bautista-García P, Reyes JL, Martín D, Namorado MC, Chavez-Munguía B, Soria-Castro E, Huber O, González-Mariscal L
American journal of physiology. Renal physiology 2013 Jan 1;304(1):F77-87
American journal of physiology. Renal physiology 2013 Jan 1;304(1):F77-87
Organotypic brain slices: a model to study the neurovascular unit micro-environment in epilepsies.
Morin-Brureau M, De Bock F, Lerner-Natoli M
Fluids and barriers of the CNS 2013 Feb 7;10(1):11
Fluids and barriers of the CNS 2013 Feb 7;10(1):11
Expression of claudins -2 and -4 and cingulin is coordinated with the start of stratification and differentiation in corneal epithelial cells: retinoic acid reversibly disrupts epithelial barrier.
Ortiz-Melo MT, Sánchez-Guzmán E, González-Robles A, Valdés J, Gómez-Flores E, Castro-Muñozledo F
Biology open 2013 Feb 15;2(2):132-43
Biology open 2013 Feb 15;2(2):132-43
Application of a new wall-less plate technology to complex multistep cell-based investigations using suspension cells.
Quiñones GA, Moore TI, Nicholes K, Lee H, Kim S, Sun L, Jeon NL, Stephan JP
Blood 2013 Feb 14;121(7):e25-33
Blood 2013 Feb 14;121(7):e25-33
Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells.
Xia Y, Nivet E, Sancho-Martinez I, Gallegos T, Suzuki K, Okamura D, Wu MZ, Dubova I, Esteban CR, Montserrat N, Campistol JM, Izpisua Belmonte JC
Nature cell biology 2013 Dec;15(12):1507-15
Nature cell biology 2013 Dec;15(12):1507-15
Epicardial function of canonical Wnt-, Hedgehog-, Fgfr1/2-, and Pdgfra-signalling.
Rudat C, Norden J, Taketo MM, Kispert A
Cardiovascular research 2013 Dec 1;100(3):411-21
Cardiovascular research 2013 Dec 1;100(3):411-21
Cryo-immunoelectron microscopy of adherent cells improved by the use of electrospun cell culture substrates.
Schmiedinger T, Vogel GF, Eiter O, Pfaller K, Kaufmann WA, Flörl A, Gutleben K, Schönherr S, Witting B, Lechleitner TW, Ebner HL, Seppi T, Hess MW
Traffic (Copenhagen, Denmark) 2013 Aug;14(8):886-94
Traffic (Copenhagen, Denmark) 2013 Aug;14(8):886-94
Isolation and culture of endothelial cells, pericytes and perivascular resident macrophage-like melanocytes from the young mouse ear.
Neng L, Zhang W, Hassan A, Zemla M, Kachelmeier A, Fridberger A, Auer M, Shi X
Nature protocols 2013 Apr;8(4):709-20
Nature protocols 2013 Apr;8(4):709-20
Regulation of Toll-like receptors in the choroid plexus in the immature brain after systemic inflammatory stimuli.
Stridh L, Ek CJ, Wang X, Nilsson H, Mallard C
Translational stroke research 2013 Apr;4(2):220-7
Translational stroke research 2013 Apr;4(2):220-7
Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways.
Baluk P, Hogmalm A, Bry M, Alitalo K, Bry K, McDonald DM
The American journal of pathology 2013 Apr;182(4):1434-47
The American journal of pathology 2013 Apr;182(4):1434-47
Endothelial cell, pericyte, and perivascular resident macrophage-type melanocyte interactions regulate cochlear intrastrial fluid-blood barrier permeability.
Neng L, Zhang F, Kachelmeier A, Shi X
Journal of the Association for Research in Otolaryngology : JARO 2013 Apr;14(2):175-85
Journal of the Association for Research in Otolaryngology : JARO 2013 Apr;14(2):175-85
Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes.
Chan YR, Chen K, Duncan SR, Lathrop KL, Latoche JD, Logar AJ, Pociask DA, Wahlberg BJ, Ray P, Ray A, Pilewski JM, Kolls JK
The Journal of allergy and clinical immunology 2013 Apr;131(4):1117-29, 1129.e1-5
The Journal of allergy and clinical immunology 2013 Apr;131(4):1117-29, 1129.e1-5
HIV-1 Tat C modulates expression of miRNA-101 to suppress VE-cadherin in human brain microvascular endothelial cells.
Mishra R, Singh SK
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Apr 3;33(14):5992-6000
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Apr 3;33(14):5992-6000
Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis.
Qian X, Mruk DD, Wong EW, Cheng CY
American journal of physiology. Endocrinology and metabolism 2013 Apr 1;304(7):E757-69
American journal of physiology. Endocrinology and metabolism 2013 Apr 1;304(7):E757-69
NC1 domain of collagen α3(IV) derived from the basement membrane regulates Sertoli cell blood-testis barrier dynamics.
Wong EW, Cheng CY
Spermatogenesis 2013 Apr 1;3(2):e25465
Spermatogenesis 2013 Apr 1;3(2):e25465
Using 32-cell stage Xenopus embryos to probe PCP signaling.
Lee HS, Sokol SY, Moody SA, Daar IO
Methods in molecular biology (Clifton, N.J.) 2012;839:91-104
Methods in molecular biology (Clifton, N.J.) 2012;839:91-104
Analysis of the RPE sheet in the rd10 retinal degeneration model.
Chrenek MA, Dalal N, Gardner C, Grossniklaus H, Jiang Y, Boatright JH, Nickerson JM
Advances in experimental medicine and biology 2012;723:641-7
Advances in experimental medicine and biology 2012;723:641-7
The T box transcription factor TBX2 promotes epithelial-mesenchymal transition and invasion of normal and malignant breast epithelial cells.
Wang B, Lindley LE, Fernandez-Vega V, Rieger ME, Sims AH, Briegel KJ
PloS one 2012;7(7):e41355
PloS one 2012;7(7):e41355
Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases.
Mendoza-Naranjo A, Cormie P, Serrano AE, Hu R, O'Neill S, Wang CM, Thrasivoulou C, Power KT, White A, Serena T, Phillips AR, Becker DL
PloS one 2012;7(5):e37374
PloS one 2012;7(5):e37374
Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity.
Yu T, Chen X, Zhang W, Li J, Xu R, Wang TC, Ai W, Liu C
PloS one 2012;7(2):e32492
PloS one 2012;7(2):e32492
Py2T murine breast cancer cells, a versatile model of TGFβ-induced EMT in vitro and in vivo.
Waldmeier L, Meyer-Schaller N, Diepenbruck M, Christofori G
PloS one 2012;7(11):e48651
PloS one 2012;7(11):e48651
Identification of new binding partners of the chemosensory signaling protein Gγ13 expressed in taste and olfactory sensory cells.
Liu Z, Fenech C, Cadiou H, Grall S, Tili E, Laugerette F, Wiencis A, Grosmaitre X, Montmayeur JP
Frontiers in cellular neuroscience 2012;6:26
Frontiers in cellular neuroscience 2012;6:26
Notch signaling promotes the corneal epithelium wound healing.
Lu H, Lu Q, Zheng Y, Li Q
Molecular vision 2012;18:403-11
Molecular vision 2012;18:403-11
ZO-1 regulates Erk, Smad1/5/8, Smad2, and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells.
Xu J, Lim SB, Ng MY, Ali SM, Kausalya JP, Limviphuvadh V, Maurer-Stroh S, Hunziker W
Stem cells (Dayton, Ohio) 2012 Sep;30(9):1885-900
Stem cells (Dayton, Ohio) 2012 Sep;30(9):1885-900
Role of tight junction proteins in gastroesophageal reflux disease.
Mönkemüller K, Wex T, Kuester D, Fry LC, Kandulski A, Kropf S, Roessner A, Malfertheiner P
BMC gastroenterology 2012 Sep 20;12:128
BMC gastroenterology 2012 Sep 20;12:128
Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration.
Kimura TE, Merritt AJ, Lock FR, Eckert JJ, Fleming TP, Garrod DR
Developmental biology 2012 Sep 15;369(2):286-97
Developmental biology 2012 Sep 15;369(2):286-97
Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells.
Lopez-Ramirez MA, Fischer R, Torres-Badillo CC, Davies HA, Logan K, Pfizenmaier K, Male DK, Sharrack B, Romero IA
Journal of immunology (Baltimore, Md. : 1950) 2012 Sep 15;189(6):3130-9
Journal of immunology (Baltimore, Md. : 1950) 2012 Sep 15;189(6):3130-9
Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis.
Iden S, van Riel WE, Schäfer R, Song JY, Hirose T, Ohno S, Collard JG
Cancer cell 2012 Sep 11;22(3):389-403
Cancer cell 2012 Sep 11;22(3):389-403
Epiprofin/Sp6 regulates Wnt-BMP signaling and the establishment of cellular junctions during the bell stage of tooth development.
Ibarretxe G, Aurrekoetxea M, Crende O, Badiola I, Jimenez-Rojo L, Nakamura T, Yamada Y, Unda F
Cell and tissue research 2012 Oct;350(1):95-107
Cell and tissue research 2012 Oct;350(1):95-107
Filamin A is a regulator of blood-testis barrier assembly during postnatal development in the rat testis.
Su W, Mruk DD, Lie PP, Lui WY, Cheng CY
Endocrinology 2012 Oct;153(10):5023-35
Endocrinology 2012 Oct;153(10):5023-35
Regulation of the blood-testis barrier by coxsackievirus and adenovirus receptor.
Su L, Mruk DD, Cheng CY
American journal of physiology. Cell physiology 2012 Oct 15;303(8):C843-53
American journal of physiology. Cell physiology 2012 Oct 15;303(8):C843-53
Lentiviral transduction of rat Sertoli cells as a means to modify gene expression.
Nicholls PK, Stanton PG, Rainczuk KE, Qian H, Gregorevic P, Harrison CA
Spermatogenesis 2012 Oct 1;2(4):279-284
Spermatogenesis 2012 Oct 1;2(4):279-284
BMP4 sufficiency to induce choroid plexus epithelial fate from embryonic stem cell-derived neuroepithelial progenitors.
Watanabe M, Kang YJ, Davies LM, Meghpara S, Lau K, Chung CY, Kathiriya J, Hadjantonakis AK, Monuki ES
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Nov 7;32(45):15934-45
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Nov 7;32(45):15934-45
Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.
Guillemot L, Schneider Y, Brun P, Castagliuolo I, Pizzuti D, Martines D, Jond L, Bongiovanni M, Citi S
Journal of cell science 2012 Nov 1;125(Pt 21):5005-14
Journal of cell science 2012 Nov 1;125(Pt 21):5005-14
Differential effects of flavonoids on barrier integrity in human intestinal Caco-2 cells.
Noda S, Tanabe S, Suzuki T
Journal of agricultural and food chemistry 2012 May 9;60(18):4628-33
Journal of agricultural and food chemistry 2012 May 9;60(18):4628-33
Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys.
Soofi A, Levitan I, Dressler GR
Developmental biology 2012 May 1;365(1):241-50
Developmental biology 2012 May 1;365(1):241-50
Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells.
Lapierre LA, Avant KM, Caldwell CM, Oztan A, Apodaca G, Knowles BC, Roland JT, Ducharme NA, Goldenring JR
Molecular biology of the cell 2012 Jun;23(12):2302-18
Molecular biology of the cell 2012 Jun;23(12):2302-18
Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid-blood barrier.
Zhang W, Dai M, Fridberger A, Hassan A, Degagne J, Neng L, Zhang F, He W, Ren T, Trune D, Auer M, Shi X
Proceedings of the National Academy of Sciences of the United States of America 2012 Jun 26;109(26):10388-93
Proceedings of the National Academy of Sciences of the United States of America 2012 Jun 26;109(26):10388-93
Overexpression of the gap junction protein Cx43 as found in diabetic foot ulcers can retard fibroblast migration.
Mendoza-Naranjo A, Cormie P, Serrano AE, Wang CM, Thrasivoulou C, Sutcliffe JE, Gilmartin DJ, Tsui J, Serena TE, Phillips AR, Becker DL
Cell biology international 2012 Jul;36(7):661-7
Cell biology international 2012 Jul;36(7):661-7
Cx43 associates with Na(v)1.5 in the cardiomyocyte perinexus.
Rhett JM, Ongstad EL, Jourdan J, Gourdie RG
The Journal of membrane biology 2012 Jul;245(7):411-22
The Journal of membrane biology 2012 Jul;245(7):411-22
Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat.
Lie PP, Mruk DD, Mok KW, Su L, Lee WM, Cheng CY
Proceedings of the National Academy of Sciences of the United States of America 2012 Jul 31;109(31):12562-7
Proceedings of the National Academy of Sciences of the United States of America 2012 Jul 31;109(31):12562-7
Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk.
Matise LA, Palmer TD, Ashby WJ, Nashabi A, Chytil A, Aakre M, Pickup MW, Gorska AE, Zijlstra A, Moses HL
Breast cancer research : BCR 2012 Jul 2;14(4):R98
Breast cancer research : BCR 2012 Jul 2;14(4):R98
Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells.
Lécuyer H, Nassif X, Coureuil M
Infection and immunity 2012 Jan;80(1):175-86
Infection and immunity 2012 Jan;80(1):175-86
ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium.
Leung KW, Gvritishvili A, Liu Y, Tombran-Tink J
Journal of molecular neuroscience : MN 2012 Jan;46(1):122-37
Journal of molecular neuroscience : MN 2012 Jan;46(1):122-37
Bioartificial Renal Epithelial Cell System (BRECS): A Compact, Cryopreservable Extracorporeal Renal Replacement Device.
Buffington DA, Pino CJ, Chen L, Westover AJ, Hageman G, Humes HD
Cell medicine 2012 Jan;4(1):33-43
Cell medicine 2012 Jan;4(1):33-43
AST-120 ameliorates epithelial-to-mesenchymal transition and interstitial fibrosis in the kidneys of chronic kidney disease rats.
Bolati D, Shimizu H, Niwa T
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2012 Jan;22(1):176-80
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2012 Jan;22(1):176-80
Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b.
Cheung ID, Bagnat M, Ma TP, Datta A, Evason K, Moore JC, Lawson ND, Mostov KE, Moens CB, Stainier DY
Developmental biology 2012 Jan 1;361(1):68-78
Developmental biology 2012 Jan 1;361(1):68-78
Multi-cellular rosettes in the mouse visceral endoderm facilitate the ordered migration of anterior visceral endoderm cells.
Trichas G, Smith AM, White N, Wilkins V, Watanabe T, Moore A, Joyce B, Sugnaseelan J, Rodriguez TA, Kay D, Baker RE, Maini PK, Srinivas S
PLoS biology 2012 Feb;10(2):e1001256
PLoS biology 2012 Feb;10(2):e1001256
Good Caco-2 cell culture practices.
Natoli M, Leoni BD, D'Agnano I, Zucco F, Felsani A
Toxicology in vitro : an international journal published in association with BIBRA 2012 Dec;26(8):1243-6
Toxicology in vitro : an international journal published in association with BIBRA 2012 Dec;26(8):1243-6
Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT).
Grassian AR, Lin F, Barrett R, Liu Y, Jiang W, Korpal M, Astley H, Gitterman D, Henley T, Howes R, Levell J, Korn JM, Pagliarini R
The Journal of biological chemistry 2012 Dec 7;287(50):42180-94
The Journal of biological chemistry 2012 Dec 7;287(50):42180-94
Tbx18 function in epicardial development.
Greulich F, Farin HF, Schuster-Gossler K, Kispert A
Cardiovascular research 2012 Dec 1;96(3):476-83
Cardiovascular research 2012 Dec 1;96(3):476-83
Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells.
Direnzo D, Hess DA, Damsz B, Hallett JE, Marshall B, Goswami C, Liu Y, Deering T, Macdonald RJ, Konieczny SF
Gastroenterology 2012 Aug;143(2):469-80
Gastroenterology 2012 Aug;143(2):469-80
Interferon-gamma signals via an ERK1/2-ARF6 pathway to promote bacterial internalization by gut epithelia.
Smyth D, McKay CM, Gulbransen BD, Phan VC, Wang A, McKay DM
Cellular microbiology 2012 Aug;14(8):1257-70
Cellular microbiology 2012 Aug;14(8):1257-70
ETV5 transcription factor is overexpressed in ovarian cancer and regulates cell adhesion in ovarian cancer cells.
Llauradó M, Abal M, Castellví J, Cabrera S, Gil-Moreno A, Pérez-Benavente A, Colás E, Doll A, Dolcet X, Matias-Guiu X, Vazquez-Levin M, Reventós J, Ruiz A
International journal of cancer 2012 Apr 1;130(7):1532-43
International journal of cancer 2012 Apr 1;130(7):1532-43
Isolation and properties of an in vitro human outer blood-retinal barrier model.
Hamilton RD, Leach L
Methods in molecular biology (Clifton, N.J.) 2011;686:401-16
Methods in molecular biology (Clifton, N.J.) 2011;686:401-16
Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor.
Chi F, Wang L, Zheng X, Wu CH, Jong A, Sheard MA, Shi W, Huang SH
PloS one 2011;6(9):e25016
PloS one 2011;6(9):e25016
Indoxyl sulfate induces epithelial-to-mesenchymal transition in rat kidneys and human proximal tubular cells.
Bolati D, Shimizu H, Higashiyama Y, Nishijima F, Niwa T
American journal of nephrology 2011;34(4):318-23
American journal of nephrology 2011;34(4):318-23
Tight junctions in brain barriers during central nervous system inflammation.
Coisne C, Engelhardt B
Antioxidants & redox signaling 2011 Sep 1;15(5):1285-303
Antioxidants & redox signaling 2011 Sep 1;15(5):1285-303
Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke.
Tang XN, Zheng Z, Giffard RG, Yenari MA
Annals of neurology 2011 Oct;70(4):606-15
Annals of neurology 2011 Oct;70(4):606-15
Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis.
Pfeiffer F, Schäfer J, Lyck R, Makrides V, Brunner S, Schaeren-Wiemers N, Deutsch U, Engelhardt B
Acta neuropathologica 2011 Nov;122(5):601-14
Acta neuropathologica 2011 Nov;122(5):601-14
Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis.
Fredenburgh LE, Velandia MM, Ma J, Olszak T, Cernadas M, Englert JA, Chung SW, Liu X, Begay C, Padera RF, Blumberg RS, Walsh SR, Baron RM, Perrella MA
Journal of immunology (Baltimore, Md. : 1950) 2011 Nov 15;187(10):5255-67
Journal of immunology (Baltimore, Md. : 1950) 2011 Nov 15;187(10):5255-67
Hepatocyte nuclear factor 4 alpha is associated with mesenchymal-epithelial transition in developing kidneys of C57BL/6 mice.
Kanazawa T, Ichii O, Otsuka S, Namiki Y, Hashimoto Y, Kon Y
The Journal of veterinary medical science 2011 May;73(5):601-7
The Journal of veterinary medical science 2011 May;73(5):601-7
Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1.
Rhett JM, Jourdan J, Gourdie RG
Molecular biology of the cell 2011 May;22(9):1516-28
Molecular biology of the cell 2011 May;22(9):1516-28
Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function.
Gruber R, Elias PM, Crumrine D, Lin TK, Brandner JM, Hachem JP, Presland RB, Fleckman P, Janecke AR, Sandilands A, McLean WH, Fritsch PO, Mildner M, Tschachler E, Schmuth M
The American journal of pathology 2011 May;178(5):2252-63
The American journal of pathology 2011 May;178(5):2252-63
Comparison of tight junction protein expression in the ciliary epithelia of mouse, rabbit, cat and human eyes.
Karim MJ, Biswas S, Bhattacherjee P, Paterson CA
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2011 Jun;86(3):161-7
Biotechnic & histochemistry : official publication of the Biological Stain Commission 2011 Jun;86(3):161-7
Cell growing density affects the structural and functional properties of Caco-2 differentiated monolayer.
Natoli M, Leoni BD, D'Agnano I, D'Onofrio M, Brandi R, Arisi I, Zucco F, Felsani A
Journal of cellular physiology 2011 Jun;226(6):1531-43
Journal of cellular physiology 2011 Jun;226(6):1531-43
Drug transporters and blood--testis barrier function.
Su L, Mruk DD, Lee WM, Cheng CY
The Journal of endocrinology 2011 Jun;209(3):337-51
The Journal of endocrinology 2011 Jun;209(3):337-51
Synthetic gelatinases inhibitor attenuates electromagnetic pulse-induced blood-brain barrier disruption by inhibiting gelatinases-mediated ZO-1 degradation in rats.
Qiu LB, Zhou Y, Wang Q, Yang LL, Liu HQ, Xu SL, Qi YH, Ding GR, Guo GZ
Toxicology 2011 Jul 11;285(1-2):31-8
Toxicology 2011 Jul 11;285(1-2):31-8
The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy.
Xiang X, Phung Y, Feng M, Nagashima K, Zhang J, Broaddus VC, Hassan R, Fitzgerald D, Ho M
PloS one 2011 Jan 31;6(1):e14640
PloS one 2011 Jan 31;6(1):e14640
Nodal dependent differential localisation of dishevelled-2 demarcates regions of differing cell behaviour in the visceral endoderm.
Trichas G, Joyce B, Crompton LA, Wilkins V, Clements M, Tada M, Rodriguez TA, Srinivas S
PLoS biology 2011 Feb;9(2):e1001019
PLoS biology 2011 Feb;9(2):e1001019
ZO-1 determines adherens and gap junction localization at intercalated disks.
Palatinus JA, O'Quinn MP, Barker RJ, Harris BS, Jourdan J, Gourdie RG
American journal of physiology. Heart and circulatory physiology 2011 Feb;300(2):H583-94
American journal of physiology. Heart and circulatory physiology 2011 Feb;300(2):H583-94
Activated Met signalling in the developing mouse heart leads to cardiac disease.
Leo C, Sala V, Morello M, Chiribiri A, Riess I, Mancardi D, Schiaffino S, Ponzetto C, Crepaldi T
PloS one 2011 Feb 9;6(2):e14675
PloS one 2011 Feb 9;6(2):e14675
Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage.
Zehendner CM, Librizzi L, de Curtis M, Kuhlmann CR, Luhmann HJ
PloS one 2011 Feb 22;6(2):e16760
PloS one 2011 Feb 22;6(2):e16760
14-3-3σ and p63 play opposing roles in epidermal tumorigenesis.
Li Q, Sambandam SA, Lu HJ, Thomson A, Kim SH, Lu H, Xin Y, Lu Q
Carcinogenesis 2011 Dec;32(12):1782-8
Carcinogenesis 2011 Dec;32(12):1782-8
A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination.
Plageman TF Jr, Chauhan BK, Yang C, Jaudon F, Shang X, Zheng Y, Lou M, Debant A, Hildebrand JD, Lang RA
Development (Cambridge, England) 2011 Dec;138(23):5177-88
Development (Cambridge, England) 2011 Dec;138(23):5177-88
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.
Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, Terouz S, Sabbagh M, Wosik K, Bourbonnière L, Bernard M, van Horssen J, de Vries HE, Charron F, Prat A
Science (New York, N.Y.) 2011 Dec 23;334(6063):1727-31
Science (New York, N.Y.) 2011 Dec 23;334(6063):1727-31
Interleukin-1alpha is a regulator of the blood-testis barrier.
Lie PP, Cheng CY, Mruk DD
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Apr;25(4):1244-53
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Apr;25(4):1244-53
IKK1 control of epidermal differentiation is modulated by notch signaling.
Xin Y, Lu Q, Li Q
The American journal of pathology 2011 Apr;178(4):1568-77
The American journal of pathology 2011 Apr;178(4):1568-77
Invasive behavior of ulcerative colitis-associated carcinoma is related to reduced expression of CD44 extracellular domain: comparison with sporadic colon carcinoma.
Mikami T, Yoshida T, Numata Y, Kikuchi M, Araki K, Nakada N, Okayasu I
Diagnostic pathology 2011 Apr 7;6:30
Diagnostic pathology 2011 Apr 7;6:30
Roles of pre-treatment time and junctional proteins in Caco-2 cell microparticle uptake.
Moyes SM, Morris JF, Carr KE
International journal of pharmaceutics 2011 Apr 4;407(1-2):21-30
International journal of pharmaceutics 2011 Apr 4;407(1-2):21-30
Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo.
Alarcon VB
Biology of reproduction 2010 Sep;83(3):347-58
Biology of reproduction 2010 Sep;83(3):347-58
Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth.
Yoshida T, Miyoshi J, Takai Y, Thesleff I
Developmental dynamics : an official publication of the American Association of Anatomists 2010 Oct;239(10):2558-69
Developmental dynamics : an official publication of the American Association of Anatomists 2010 Oct;239(10):2558-69
Effects of long-term progesterone on developmental and functional aspects of porcine uterine epithelia and vasculature: progesterone alone does not support development of uterine glands comparable to that of pregnancy.
Bailey DW, Dunlap KA, Frank JW, Erikson DW, White BG, Bazer FW, Burghardt RC, Johnson GA
Reproduction (Cambridge, England) 2010 Oct;140(4):583-94
Reproduction (Cambridge, England) 2010 Oct;140(4):583-94
Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo.
Su L, Cheng CY, Mruk DD
The international journal of biochemistry & cell biology 2010 Nov;42(11):1864-75
The international journal of biochemistry & cell biology 2010 Nov;42(11):1864-75
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis.
Gonzalez-Suarez E, Jacob AP, Jones J, Miller R, Roudier-Meyer MP, Erwert R, Pinkas J, Branstetter D, Dougall WC
Nature 2010 Nov 4;468(7320):103-7
Nature 2010 Nov 4;468(7320):103-7
Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization.
Lam CK, Yoo T, Hiner B, Liu Z, Grutzendler J
Nature 2010 May 27;465(7297):478-82
Nature 2010 May 27;465(7297):478-82
Responsiveness to PI3K and MEK inhibitors in breast cancer. Use of a 3D culture system to study pathways related to hormone independence in mice.
Polo ML, Arnoni MV, Riggio M, Wargon V, Lanari C, Novaro V
PloS one 2010 May 26;5(5):e10786
PloS one 2010 May 26;5(5):e10786
Mono-(2-ethylhexyl) phthalate-induced disruption of junctional complexes in the seminiferous epithelium of the rodent testis is mediated by MMP2.
Yao PL, Lin YC, Richburg JH
Biology of reproduction 2010 Mar;82(3):516-27
Biology of reproduction 2010 Mar;82(3):516-27
Assessing the role of claudins in maintaining the integrity of epididymal tight junctions using novel human epididymal cell lines.
Dubé E, Dufresne J, Chan PT, Hermo L, Cyr DG
Biology of reproduction 2010 Jun;82(6):1119-28
Biology of reproduction 2010 Jun;82(6):1119-28
Chlamydia pneumoniae infection in polarized epithelial cell lines.
Törmäkangas L, Markkula E, Lounatmaa K, Puolakkainen M
Infection and immunity 2010 Jun;78(6):2714-22
Infection and immunity 2010 Jun;78(6):2714-22
Epithelial-mesenchymal transition in rhesus monkey embryonic stem cell colonies: the role of culturing conditions.
Maranca-Hüwel B, Denker HW
In vitro cellular & developmental biology. Animal 2010 Jun;46(6):516-28
In vitro cellular & developmental biology. Animal 2010 Jun;46(6):516-28
Gonadotropins regulate rat testicular tight junctions in vivo.
McCabe MJ, Tarulli GA, Meachem SJ, Robertson DM, Smooker PM, Stanton PG
Endocrinology 2010 Jun;151(6):2911-22
Endocrinology 2010 Jun;151(6):2911-22
Learning to predict relapse in invasive ductal carcinomas based on the subcellular localization of junctional proteins.
Asgarian N, Hu X, Aktary Z, Chapman KA, Lam L, Chibbar R, Mackey J, Greiner R, Pasdar M
Breast cancer research and treatment 2010 Jun;121(2):527-38
Breast cancer research and treatment 2010 Jun;121(2):527-38
The role of protein kinase C in the opening of blood-brain barrier induced by electromagnetic pulse.
Qiu LB, Ding GR, Li KC, Wang XW, Zhou Y, Zhou YC, Li YR, Guo GZ
Toxicology 2010 Jun 29;273(1-3):29-34
Toxicology 2010 Jun 29;273(1-3):29-34
Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching.
Strasser GA, Kaminker JS, Tessier-Lavigne M
Blood 2010 Jun 17;115(24):5102-10
Blood 2010 Jun 17;115(24):5102-10
The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens.
Wiley LA, Dattilo LK, Kang KB, Giovannini M, Beebe DC
Investigative ophthalmology & visual science 2010 Jul;51(7):3611-8
Investigative ophthalmology & visual science 2010 Jul;51(7):3611-8
Arecoline induced disruption of expression and localization of the tight junctional protein ZO-1 is dependent on the HER 2 expression in human endometrial Ishikawa cells.
Giri S, Poindexter KM, Sundar SN, Firestone GL
BMC cell biology 2010 Jul 6;11:53
BMC cell biology 2010 Jul 6;11:53
A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development.
Xie J, Farage E, Sugimoto M, Anand-Apte B
BMC developmental biology 2010 Jul 23;10:76
BMC developmental biology 2010 Jul 23;10:76
Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells.
Chang TL, Ito K, Ko TK, Liu Q, Salto-Tellez M, Yeoh KG, Fukamachi H, Ito Y
Gastroenterology 2010 Jan;138(1):255-65.e1-3
Gastroenterology 2010 Jan;138(1):255-65.e1-3
Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination.
Plageman TF Jr, Chung MI, Lou M, Smith AN, Hildebrand JD, Wallingford JB, Lang RA
Development (Cambridge, England) 2010 Feb;137(3):405-15
Development (Cambridge, England) 2010 Feb;137(3):405-15
14-3-3sigma controls corneal epithelial cell proliferation and differentiation through the Notch signaling pathway.
Xin Y, Lu Q, Li Q
Biochemical and biophysical research communications 2010 Feb 19;392(4):593-8
Biochemical and biophysical research communications 2010 Feb 19;392(4):593-8
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures.
Ploss A, Khetani SR, Jones CT, Syder AJ, Trehan K, Gaysinskaya VA, Mu K, Ritola K, Rice CM, Bhatia SN
Proceedings of the National Academy of Sciences of the United States of America 2010 Feb 16;107(7):3141-5
Proceedings of the National Academy of Sciences of the United States of America 2010 Feb 16;107(7):3141-5
Macrophages increase microparticle uptake by enterocyte-like Caco-2 cell monolayers.
Moyes SM, Morris JF, Carr KE
Journal of anatomy 2010 Dec;217(6):740-54
Journal of anatomy 2010 Dec;217(6):740-54
Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1.
Fang X, Neyrinck AP, Matthay MA, Lee JW
The Journal of biological chemistry 2010 Aug 20;285(34):26211-22
The Journal of biological chemistry 2010 Aug 20;285(34):26211-22
Impairment of intestinal barrier and secretory function as well as egg excretion during intestinal schistosomiasis occur independently of mouse mast cell protease-1.
Rychter JW, Van Nassauw L, Brown JK, Van Marck E, Knight PA, Miller HR, Kroese AB, Timmermans JP
Parasite immunology 2010 Apr;32(4):221-31
Parasite immunology 2010 Apr;32(4):221-31
Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement.
Bauer AT, Bürgers HF, Rabie T, Marti HH
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010 Apr;30(4):837-48
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010 Apr;30(4):837-48
Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain.
Mullier A, Bouret SG, Prevot V, Dehouck B
The Journal of comparative neurology 2010 Apr 1;518(7):943-62
The Journal of comparative neurology 2010 Apr 1;518(7):943-62
A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells.
Sonoda S, Spee C, Barron E, Ryan SJ, Kannan R, Hinton DR
Nature protocols 2009;4(5):662-73
Nature protocols 2009;4(5):662-73
Impaired transcription factor interplay in addition to advanced glycation end products suppress podocalyxin expression in high glucose-treated human podocytes.
Drossopoulou GI, Tsotakos NE, Tsilibary EC
American journal of physiology. Renal physiology 2009 Sep;297(3):F594-603
American journal of physiology. Renal physiology 2009 Sep;297(3):F594-603
Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis.
Li Y, Tan X, Dai C, Stolz DB, Wang D, Liu Y
Journal of the American Society of Nephrology : JASN 2009 Sep;20(9):1907-18
Journal of the American Society of Nephrology : JASN 2009 Sep;20(9):1907-18
The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation.
Dammermann A, Pemble H, Mitchell BJ, McLeod I, Yates JR 3rd, Kintner C, Desai AB, Oegema K
Genes & development 2009 Sep 1;23(17):2046-59
Genes & development 2009 Sep 1;23(17):2046-59
Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility.
van Miltenburg MH, Lalai R, de Bont H, van Waaij E, Beggs H, Danen EH, van de Water B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Oct;23(10):3482-93
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Oct;23(10):3482-93
Missense mutations in a retinal pigment epithelium protein, bestrophin-1, cause retinitis pigmentosa.
Davidson AE, Millar ID, Urquhart JE, Burgess-Mullan R, Shweikh Y, Parry N, O'Sullivan J, Maher GJ, McKibbin M, Downes SM, Lotery AJ, Jacobson SG, Brown PD, Black GC, Manson FD
American journal of human genetics 2009 Nov;85(5):581-92
American journal of human genetics 2009 Nov;85(5):581-92
Disruption of the blood-testis barrier integrity by bisphenol A in vitro: is this a suitable model for studying blood-testis barrier dynamics?
Li MW, Mruk DD, Lee WM, Cheng CY
The international journal of biochemistry & cell biology 2009 Nov;41(11):2302-14
The international journal of biochemistry & cell biology 2009 Nov;41(11):2302-14
Tight junctions in Hailey-Hailey and Darier's diseases.
Raiko L, Leinonen P, Hägg PM, Peltonen J, Oikarinen A, Peltonen S
Dermatology reports 2009 Nov 16;1(1):e1
Dermatology reports 2009 Nov 16;1(1):e1
The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression.
Pinton P, Nougayrède JP, Del Rio JC, Moreno C, Marin DE, Ferrier L, Bracarense AP, Kolf-Clauw M, Oswald IP
Toxicology and applied pharmacology 2009 May 15;237(1):41-8
Toxicology and applied pharmacology 2009 May 15;237(1):41-8
A novel role for SED1 (MFG-E8) in maintaining the integrity of the epididymal epithelium.
Raymond AS, Shur BD
Journal of cell science 2009 Mar 15;122(Pt 6):849-58
Journal of cell science 2009 Mar 15;122(Pt 6):849-58
Directed evolution of adeno-associated virus to an infectious respiratory virus.
Excoffon KJ, Koerber JT, Dickey DD, Murtha M, Keshavjee S, Kaspar BK, Zabner J, Schaffer DV
Proceedings of the National Academy of Sciences of the United States of America 2009 Mar 10;106(10):3865-70
Proceedings of the National Academy of Sciences of the United States of America 2009 Mar 10;106(10):3865-70
Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis.
Mori M, Nakagami H, Koibuchi N, Miura K, Takami Y, Koriyama H, Hayashi H, Sabe H, Mochizuki N, Morishita R, Kaneda Y
Molecular biology of the cell 2009 Jul;20(13):3115-24
Molecular biology of the cell 2009 Jul;20(13):3115-24
Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction.
Jechlinger M, Podsypanina K, Varmus H
Genes & development 2009 Jul 15;23(14):1677-88
Genes & development 2009 Jul 15;23(14):1677-88
Intestinal cytoskeleton degradation precedes tight junction loss following hemorrhagic shock.
Thuijls G, de Haan JJ, Derikx JP, Daissormont I, Hadfoune M, Heineman E, Buurman WA
Shock (Augusta, Ga.) 2009 Feb;31(2):164-9
Shock (Augusta, Ga.) 2009 Feb;31(2):164-9
Dietary glutamine and oral antibiotics each improve indexes of gut barrier function in rat short bowel syndrome.
Tian J, Hao L, Chandra P, Jones DP, Willams IR, Gewirtz AT, Ziegler TR
American journal of physiology. Gastrointestinal and liver physiology 2009 Feb;296(2):G348-55
American journal of physiology. Gastrointestinal and liver physiology 2009 Feb;296(2):G348-55
Sertoli cell Dicer is essential for spermatogenesis in mice.
Papaioannou MD, Pitetti JL, Ro S, Park C, Aubry F, Schaad O, Vejnar CE, Kühne F, Descombes P, Zdobnov EM, McManus MT, Guillou F, Harfe BD, Yan W, Jégou B, Nef S
Developmental biology 2009 Feb 1;326(1):250-9
Developmental biology 2009 Feb 1;326(1):250-9
Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier.
Su L, Cheng CY, Mruk DD
The international journal of biochemistry & cell biology 2009 Dec;41(12):2578-87
The international journal of biochemistry & cell biology 2009 Dec;41(12):2578-87
Expression of tight-junction proteins in the inflamed and clinically uninvolved skin in patients with venous leg ulcers.
Zorko MS, Veranic P, Leskovec NK, Pavlović MD, Lunder T
Clinical and experimental dermatology 2009 Dec;34(8):e949-52
Clinical and experimental dermatology 2009 Dec;34(8):e949-52
Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium.
Cattin AL, Le Beyec J, Barreau F, Saint-Just S, Houllier A, Gonzalez FJ, Robine S, Pinçon-Raymond M, Cardot P, Lacasa M, Ribeiro A
Molecular and cellular biology 2009 Dec;29(23):6294-308
Molecular and cellular biology 2009 Dec;29(23):6294-308
Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent of ERalpha.
Lam L, Hu X, Aktary Z, Andrews DW, Pasdar M
Breast cancer research and treatment 2009 Dec;118(3):605-21
Breast cancer research and treatment 2009 Dec;118(3):605-21
A cell polarity protein aPKClambda is required for eye lens formation and growth.
Sugiyama Y, Akimoto K, Robinson ML, Ohno S, Quinlan RA
Developmental biology 2009 Dec 15;336(2):246-56
Developmental biology 2009 Dec 15;336(2):246-56
Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium.
Lie PP, Mruk DD, Lee WM, Cheng CY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Aug;23(8):2555-67
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Aug;23(8):2555-67
Increased intraocular insulin-like growth factor-I triggers blood-retinal barrier breakdown.
Haurigot V, Villacampa P, Ribera A, Llombart C, Bosch A, Nacher V, Ramos D, Ayuso E, Segovia JC, Bueren JA, Ruberte J, Bosch F
The Journal of biological chemistry 2009 Aug 21;284(34):22961-9
The Journal of biological chemistry 2009 Aug 21;284(34):22961-9
TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury.
Ey B, Eyking A, Gerken G, Podolsky DK, Cario E
The Journal of biological chemistry 2009 Aug 14;284(33):22332-22343
The Journal of biological chemistry 2009 Aug 14;284(33):22332-22343
Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome.
Huber TB, Hartleben B, Winkelmann K, Schneider L, Becker JU, Leitges M, Walz G, Haller H, Schiffer M
Journal of the American Society of Nephrology : JASN 2009 Apr;20(4):798-806
Journal of the American Society of Nephrology : JASN 2009 Apr;20(4):798-806
Rapid reversal of human intestinal ischemia-reperfusion induced damage by shedding of injured enterocytes and reepithelialisation.
Derikx JP, Matthijsen RA, de Bruïne AP, van Bijnen AA, Heineman E, van Dam RM, Dejong CH, Buurman WA
PloS one 2008;3(10):e3428
PloS one 2008;3(10):e3428
Different expression of occludin and ZO-1 in primary and metastatic liver tumors.
Orbán E, Szabó E, Lotz G, Kupcsulik P, Páska C, Schaff Z, Kiss A
Pathology oncology research : POR 2008 Sep;14(3):299-306
Pathology oncology research : POR 2008 Sep;14(3):299-306
Ablation of Cx47 in transgenic mice leads to the loss of MUPP1, ZONAB and multiple connexins at oligodendrocyte-astrocyte gap junctions.
Li X, Penes M, Odermatt B, Willecke K, Nagy JI
The European journal of neuroscience 2008 Oct;28(8):1503-17
The European journal of neuroscience 2008 Oct;28(8):1503-17
Localization studies of rare missense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) facilitate interpretation of genotype-phenotype relationships.
Krasnov KV, Tzetis M, Cheng J, Guggino WB, Cutting GR
Human mutation 2008 Nov;29(11):1364-72
Human mutation 2008 Nov;29(11):1364-72
Postshock intervention with high-lipid enteral nutrition reduces inflammation and tissue damage.
de Haan JJ, Lubbers T, Hadfoune M, Luyer MD, Dejong CH, Buurman WA, Greve JW
Annals of surgery 2008 Nov;248(5):842-8
Annals of surgery 2008 Nov;248(5):842-8
Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke.
Gore AV, Lampugnani MG, Dye L, Dejana E, Weinstein BM
Disease models & mechanisms 2008 Nov-Dec;1(4-5):275-81
Disease models & mechanisms 2008 Nov-Dec;1(4-5):275-81
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina.
Damiani D, Alexander JJ, O'Rourke JR, McManus M, Jadhav AP, Cepko CL, Hauswirth WW, Harfe BD, Strettoi E
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 May 7;28(19):4878-87
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 May 7;28(19):4878-87
Cellular differentiation in three-dimensional lung cell cultures.
Vertrees RA, Zwischenberger JB, Boor PJ, Popov V, McCarthy M, Solley TN, Goodwin TJ
Cancer biology & therapy 2008 Mar;7(3):404-12
Cancer biology & therapy 2008 Mar;7(3):404-12
Functional and developmental analysis of the blood-brain barrier in zebrafish.
Jeong JY, Kwon HB, Ahn JC, Kang D, Kwon SH, Park JA, Kim KW
Brain research bulletin 2008 Mar 28;75(5):619-28
Brain research bulletin 2008 Mar 28;75(5):619-28
Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse.
Benton RL, Maddie MA, Minnillo DR, Hagg T, Whittemore SR
The Journal of comparative neurology 2008 Mar 1;507(1):1031-52
The Journal of comparative neurology 2008 Mar 1;507(1):1031-52
Basolateral entry and release of New and Old World arenaviruses from human airway epithelia.
Dylla DE, Michele DE, Campbell KP, McCray PB Jr
Journal of virology 2008 Jun;82(12):6034-8
Journal of virology 2008 Jun;82(12):6034-8
Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse.
Wang H, Ding T, Brown N, Yamamoto Y, Prince LS, Reese J, Paria BC
Developmental biology 2008 Jun 1;318(1):112-25
Developmental biology 2008 Jun 1;318(1):112-25
Expression and localisation of apical junctional complex proteins in lens epithelial cells.
Sugiyama Y, Prescott AR, Tholozan FM, Ohno S, Quinlan RA
Experimental eye research 2008 Jul;87(1):64-70
Experimental eye research 2008 Jul;87(1):64-70
Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression.
Paschoud S, Citi S
Molecular membrane biology 2008 Jan;25(1):1-13
Molecular membrane biology 2008 Jan;25(1):1-13
Localization of claudin-5 and ZO-1 in rat spleen sinus endothelial cells.
Uehara K, Uehara A
Histochemistry and cell biology 2008 Jan;129(1):95-103
Histochemistry and cell biology 2008 Jan;129(1):95-103
Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria.
Li Y, Kang YS, Dai C, Kiss LP, Wen X, Liu Y
The American journal of pathology 2008 Feb;172(2):299-308
The American journal of pathology 2008 Feb;172(2):299-308
Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node.
Pfeiffer F, Kumar V, Butz S, Vestweber D, Imhof BA, Stein JV, Engelhardt B
European journal of immunology 2008 Aug;38(8):2142-55
European journal of immunology 2008 Aug;38(8):2142-55
Rapid identification of differentiation markers from whole epithelial cells by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry and statistical analysis.
Marvin-Guy LF, Duncan P, Wagnière S, Antille N, Porta N, Affolter M, Kussmann M
Rapid communications in mass spectrometry : RCM 2008 Apr;22(8):1099-108
Rapid communications in mass spectrometry : RCM 2008 Apr;22(8):1099-108
mRNA expression analysis and the molecular basis of neonatal testis defects in Dmrt1 mutant mice.
Fahrioglu U, Murphy MW, Zarkower D, Bardwell VJ
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2007;1(1):42-58
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2007;1(1):42-58
Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development.
Ursini-Siegel J, Rajput AB, Lu H, Sanguin-Gendreau V, Zuo D, Papavasiliou V, Lavoie C, Turpin J, Cianflone K, Huntsman DG, Muller WJ
Molecular and cellular biology 2007 Sep;27(18):6361-71
Molecular and cellular biology 2007 Sep;27(18):6361-71
PINCH-1 promotes tubular epithelial-to-mesenchymal transition by interacting with integrin-linked kinase.
Li Y, Dai C, Wu C, Liu Y
Journal of the American Society of Nephrology : JASN 2007 Sep;18(9):2534-43
Journal of the American Society of Nephrology : JASN 2007 Sep;18(9):2534-43
Pathophysiological role of the activation of p38 mitogen-activated protein kinases in poorly differentiated gastric cancer.
Atsumi T, Kato K, Uno K, Iijima K, Koike T, Imatani A, Ohara S, Shimosegawa T
Pathology international 2007 Oct;57(10):635-44
Pathology international 2007 Oct;57(10):635-44
Astrovirus increases epithelial barrier permeability independently of viral replication.
Moser LA, Carter M, Schultz-Cherry S
Journal of virology 2007 Nov;81(21):11937-45
Journal of virology 2007 Nov;81(21):11937-45
Angiopoietin modulation of vascular endothelial growth factor: Effects on retinal endothelial cell permeability.
Peters S, Cree IA, Alexander R, Turowski P, Ockrim Z, Patel J, Boyd SR, Joussen AM, Ziemssen F, Hykin PG, Moss SE
Cytokine 2007 Nov;40(2):144-50
Cytokine 2007 Nov;40(2):144-50
Localization of ZO-1 in the nucleolus of corneal fibroblasts.
Benezra M, Greenberg RS, Masur SK
Investigative ophthalmology & visual science 2007 May;48(5):2043-9
Investigative ophthalmology & visual science 2007 May;48(5):2043-9
The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation.
Stucke VM, Timmerman E, Vandekerckhove J, Gevaert K, Hall A
Molecular biology of the cell 2007 May;18(5):1744-55
Molecular biology of the cell 2007 May;18(5):1744-55
Abnormal development of urogenital organs in Dlgh1-deficient mice.
Iizuka-Kogo A, Ishidao T, Akiyama T, Senda T
Development (Cambridge, England) 2007 May;134(9):1799-807
Development (Cambridge, England) 2007 May;134(9):1799-807
Paracellular permeability restricts airway epithelial responses to selectively allow activation by mediators at the basolateral surface.
Humlicek AL, Manzel LJ, Chin CL, Shi L, Excoffon KJ, Winter MC, Shasby DM, Look DC
Journal of immunology (Baltimore, Md. : 1950) 2007 May 15;178(10):6395-403
Journal of immunology (Baltimore, Md. : 1950) 2007 May 15;178(10):6395-403
ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architecture.
Hernandez S, Chavez Munguia B, Gonzalez-Mariscal L
Experimental cell research 2007 May 1;313(8):1533-47
Experimental cell research 2007 May 1;313(8):1533-47
Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis.
Peltonen S, Riehokainen J, Pummi K, Peltonen J
The British journal of dermatology 2007 Mar;156(3):466-72
The British journal of dermatology 2007 Mar;156(3):466-72
Differences in claudin synthesis in primary cultures of acinar cells from rat salivary gland are correlated with the specific three-dimensional organization of the cells.
Qi B, Fujita-Yoshigaki J, Michikawa H, Satoh K, Katsumata O, Sugiya H
Cell and tissue research 2007 Jul;329(1):59-70
Cell and tissue research 2007 Jul;329(1):59-70
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy.
Rigau V, Morin M, Rousset MC, de Bock F, Lebrun A, Coubes P, Picot MC, Baldy-Moulinier M, Bockaert J, Crespel A, Lerner-Natoli M
Brain : a journal of neurology 2007 Jul;130(Pt 7):1942-56
Brain : a journal of neurology 2007 Jul;130(Pt 7):1942-56
Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm.
Kan NG, Stemmler MP, Junghans D, Kanzler B, de Vries WN, Dominis M, Kemler R
Development (Cambridge, England) 2007 Jan;134(1):31-41
Development (Cambridge, England) 2007 Jan;134(1):31-41
Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1.
Li Y, Yang J, Luo JH, Dedhar S, Liu Y
Journal of the American Society of Nephrology : JASN 2007 Feb;18(2):449-60
Journal of the American Society of Nephrology : JASN 2007 Feb;18(2):449-60
Immunolocalization of tight junction proteins in blood vessels in human germinal matrix and cortex.
Anstrom JA, Thore CR, Moody DM, Brown WR
Histochemistry and cell biology 2007 Feb;127(2):205-13
Histochemistry and cell biology 2007 Feb;127(2):205-13
Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage.
Blixt A, Landgren H, Johansson BR, Carlsson P
Developmental biology 2007 Feb 1;302(1):218-29
Developmental biology 2007 Feb 1;302(1):218-29
Establishment of a human in vitro model of the outer blood-retinal barrier.
Hamilton RD, Foss AJ, Leach L
Journal of anatomy 2007 Dec;211(6):707-16
Journal of anatomy 2007 Dec;211(6):707-16
A large-scale proteomic analysis of human embryonic stem cells.
Schulz TC, Swistowska AM, Liu Y, Swistowski A, Palmarini G, Brimble SN, Sherrer E, Robins AJ, Rao MS, Zeng X
BMC genomics 2007 Dec 27;8:478
BMC genomics 2007 Dec 27;8:478
Spatial relationships of connexin36, connexin57 and zonula occludens-1 in the outer plexiform layer of mouse retina.
Ciolofan C, Lynn BD, Wellershaus K, Willecke K, Nagy JI
Neuroscience 2007 Aug 24;148(2):473-88
Neuroscience 2007 Aug 24;148(2):473-88
Gap junction adhesion is necessary for radial migration in the neocortex.
Elias LA, Wang DD, Kriegstein AR
Nature 2007 Aug 23;448(7156):901-7
Nature 2007 Aug 23;448(7156):901-7
Derivation and characterization of lentoid bodies and retinal pigment epithelial cells from monkey embryonic stem cells in vitro.
Takahashi M, Haruta M
Methods in molecular biology (Clifton, N.J.) 2006;330:417-29
Methods in molecular biology (Clifton, N.J.) 2006;330:417-29
Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins.
Chen VC, Li X, Perreault H, Nagy JI
Journal of proteome research 2006 Sep;5(9):2123-34
Journal of proteome research 2006 Sep;5(9):2123-34
Epithelial barrier characteristics and expression of cell adhesion molecules in proximal tubule-derived cell lines commonly used for in vitro toxicity studies.
Prozialeck WC, Edwards JR, Lamar PC, Smith CS
Toxicology in vitro : an international journal published in association with BIBRA 2006 Sep;20(6):942-53
Toxicology in vitro : an international journal published in association with BIBRA 2006 Sep;20(6):942-53
Characterization of epithelial cell shedding from human small intestine.
Bullen TF, Forrest S, Campbell F, Dodson AR, Hershman MJ, Pritchard DM, Turner JR, Montrose MH, Watson AJ
Laboratory investigation; a journal of technical methods and pathology 2006 Oct;86(10):1052-63
Laboratory investigation; a journal of technical methods and pathology 2006 Oct;86(10):1052-63
Glomerular sclerosis in kidneys with congenital nephrotic syndrome (NPHS1).
Kuusniemi AM, Merenmies J, Lahdenkari AT, Holmberg C, Salmela K, Karikoski R, Rapola J, Jalanko H
Kidney international 2006 Oct;70(8):1423-31
Kidney international 2006 Oct;70(8):1423-31
Differentiation of adult rat bone marrow stem cells into epithelial progenitor cells in culture.
Shu C, Li TY, Tsang LL, Fok KL, Lo PS, Zhu JX, Ho LS, Chung YW, Chan HC
Cell biology international 2006 Oct;30(10):823-8
Cell biology international 2006 Oct;30(10):823-8
Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells.
Otani T, Ichii T, Aono S, Takeichi M
The Journal of cell biology 2006 Oct 9;175(1):135-46
The Journal of cell biology 2006 Oct 9;175(1):135-46
Isolation and characterization of kidney-derived stem cells.
Gupta S, Verfaillie C, Chmielewski D, Kren S, Eidman K, Connaire J, Heremans Y, Lund T, Blackstad M, Jiang Y, Luttun A, Rosenberg ME
Journal of the American Society of Nephrology : JASN 2006 Nov;17(11):3028-40
Journal of the American Society of Nephrology : JASN 2006 Nov;17(11):3028-40
Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins.
Usatyuk PV, Parinandi NL, Natarajan V
The Journal of biological chemistry 2006 Nov 17;281(46):35554-66
The Journal of biological chemistry 2006 Nov 17;281(46):35554-66
Adult sertoli cells are not terminally differentiated in the Djungarian hamster: effect of FSH on proliferation and junction protein organization.
Tarulli GA, Stanton PG, Lerchl A, Meachem SJ
Biology of reproduction 2006 May;74(5):798-806
Biology of reproduction 2006 May;74(5):798-806
The Coxsackievirus and Adenovirus Receptor: a new adhesion protein in cochlear development.
Excoffon KJ, Avenarius MR, Hansen MR, Kimberling WJ, Najmabadi H, Smith RJ, Zabner J
Hearing research 2006 May;215(1-2):1-9
Hearing research 2006 May;215(1-2):1-9
Endothelia of term human placentae display diminished expression of tight junction proteins during preeclampsia.
Liévano S, Alarcón L, Chávez-Munguía B, González-Mariscal L
Cell and tissue research 2006 Jun;324(3):433-48
Cell and tissue research 2006 Jun;324(3):433-48
Association of connexin36 and zonula occludens-1 with zonula occludens-2 and the transcription factor zonula occludens-1-associated nucleic acid-binding protein at neuronal gap junctions in rodent retina.
Ciolofan C, Li XB, Olson C, Kamasawa N, Gebhardt BR, Yasumura T, Morita M, Rash JE, Nagy JI
Neuroscience 2006 Jun 30;140(2):433-51
Neuroscience 2006 Jun 30;140(2):433-51
CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS.
Eugenin EA, Osiecki K, Lopez L, Goldstein H, Calderon TM, Berman JW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Jan 25;26(4):1098-106
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Jan 25;26(4):1098-106
Establishment and characterization of primary and subsequent subcultures of normal mouse urothelial cells.
Kreft ME, Hudoklin S, Sterle M
Folia biologica 2005;51(5):126-32
Folia biologica 2005;51(5):126-32
Rare incorporation of bone marrow-derived cells into kidney after folic acid-induced injury.
Szczypka MS, Westover AJ, Clouthier SG, Ferrara JL, Humes HD
Stem cells (Dayton, Ohio) 2005;23(1):44-54
Stem cells (Dayton, Ohio) 2005;23(1):44-54
Epithelial barrier function in vivo is sustained despite gaps in epithelial layers.
Watson AJ, Chu S, Sieck L, Gerasimenko O, Bullen T, Campbell F, McKenna M, Rose T, Montrose MH
Gastroenterology 2005 Sep;129(3):902-12
Gastroenterology 2005 Sep;129(3):902-12
Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins.
Jacob C, Yang PC, Darmoul D, Amadesi S, Saito T, Cottrell GS, Coelho AM, Singh P, Grady EF, Perdue M, Bunnett NW
The Journal of biological chemistry 2005 Sep 9;280(36):31936-48
The Journal of biological chemistry 2005 Sep 9;280(36):31936-48
The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex.
Mertens AE, Rygiel TP, Olivo C, van der Kammen R, Collard JG
The Journal of cell biology 2005 Sep 26;170(7):1029-37
The Journal of cell biology 2005 Sep 26;170(7):1029-37
Enteropathogenic E. coli disrupts tight junction barrier function and structure in vivo.
Shifflett DE, Clayburgh DR, Koutsouris A, Turner JR, Hecht GA
Laboratory investigation; a journal of technical methods and pathology 2005 Oct;85(10):1308-24
Laboratory investigation; a journal of technical methods and pathology 2005 Oct;85(10):1308-24
Disruption of Sertoli-germ cell adhesion function in the seminiferous epithelium of the rat testis can be limited to adherens junctions without affecting the blood-testis barrier integrity: an in vivo study using an androgen suppression model.
Xia W, Wong CH, Lee NP, Lee WM, Cheng CY
Journal of cellular physiology 2005 Oct;205(1):141-57
Journal of cellular physiology 2005 Oct;205(1):141-57
Drebrin, an actin-binding, cell-type characteristic protein: induction and localization in epithelial skin tumors and cultured keratinocytes.
Peitsch WK, Hofmann I, Bulkescher J, Hergt M, Spring H, Bleyl U, Goerdt S, Franke WW
The Journal of investigative dermatology 2005 Oct;125(4):761-74
The Journal of investigative dermatology 2005 Oct;125(4):761-74
The short apical membrane half-life of rescued {Delta}F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of {Delta}F508-CFTR in polarized human airway epithelial cells.
Swiatecka-Urban A, Brown A, Moreau-Marquis S, Renuka J, Coutermarsh B, Barnaby R, Karlson KH, Flotte TR, Fukuda M, Langford GM, Stanton BA
The Journal of biological chemistry 2005 Nov 4;280(44):36762-72
The Journal of biological chemistry 2005 Nov 4;280(44):36762-72
Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina.
Koike C, Nishida A, Akimoto K, Nakaya MA, Noda T, Ohno S, Furukawa T
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Nov 2;25(44):10290-8
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Nov 2;25(44):10290-8
Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells.
Wei CJ, Francis R, Xu X, Lo CW
The Journal of biological chemistry 2005 May 20;280(20):19925-36
The Journal of biological chemistry 2005 May 20;280(20):19925-36
Ultrastructural and immunohistochemical characterization of the bovine epiblast.
Vejlsted M, Avery B, Schmidt M, Greve T, Alexopoulos N, Maddox-Hyttel P
Biology of reproduction 2005 Mar;72(3):678-86
Biology of reproduction 2005 Mar;72(3):678-86
sPAR-3, a splicing variant of PAR-3, shows cellular localization and an expression pattern different from that of PAR-3 during enterocyte polarization.
Yoshii T, Mizuno K, Hirose T, Nakajima A, Sekihara H, Ohno S
American journal of physiology. Gastrointestinal and liver physiology 2005 Mar;288(3):G564-70
American journal of physiology. Gastrointestinal and liver physiology 2005 Mar;288(3):G564-70
Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells.
Guo X, Rao JN, Liu L, Zou T, Keledjian KM, Boneva D, Marasa BS, Wang JY
American journal of physiology. Gastrointestinal and liver physiology 2005 Jun;288(6):G1159-69
American journal of physiology. Gastrointestinal and liver physiology 2005 Jun;288(6):G1159-69
Amphiregulin causes functional downregulation of adherens junctions in psoriasis.
Chung E, Cook PW, Parkos CA, Park YK, Pittelkow MR, Coffey RJ
The Journal of investigative dermatology 2005 Jun;124(6):1134-40
The Journal of investigative dermatology 2005 Jun;124(6):1134-40
Epithelial-mesenchymal transition in colonies of rhesus monkey embryonic stem cells: a model for processes involved in gastrulation.
Behr R, Heneweer C, Viebahn C, Denker HW, Thie M
Stem cells (Dayton, Ohio) 2005 Jun-Jul;23(6):805-16
Stem cells (Dayton, Ohio) 2005 Jun-Jul;23(6):805-16
Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier.
Xu H, Dawson R, Crane IJ, Liversidge J
Investigative ophthalmology & visual science 2005 Jul;46(7):2487-94
Investigative ophthalmology & visual science 2005 Jul;46(7):2487-94
Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain.
Penes MC, Li X, Nagy JI
The European journal of neuroscience 2005 Jul;22(2):404-18
The European journal of neuroscience 2005 Jul;22(2):404-18
Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion.
Hunter AW, Barker RJ, Zhu C, Gourdie RG
Molecular biology of the cell 2005 Dec;16(12):5686-98
Molecular biology of the cell 2005 Dec;16(12):5686-98
Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner.
Singh D, Solan JL, Taffet SM, Javier R, Lampe PD
The Journal of biological chemistry 2005 Aug 26;280(34):30416-21
The Journal of biological chemistry 2005 Aug 26;280(34):30416-21
Lactobacillus acidophilus protects tight junctions from aspirin damage in HT-29 cells.
Montalto M, Maggiano N, Ricci R, Curigliano V, Santoro L, Di Nicuolo F, Vecchio FM, Gasbarrini A, Gasbarrini G
Digestion 2004;69(4):225-8
Digestion 2004;69(4):225-8
Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro.
Brown KA, Aakre ME, Gorska AE, Price JO, Eltom SE, Pietenpol JA, Moses HL
Breast cancer research : BCR 2004;6(3):R215-31
Breast cancer research : BCR 2004;6(3):R215-31
Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression.
Guillemot L, Hammar E, Kaister C, Ritz J, Caille D, Jond L, Bauer C, Meda P, Citi S
Journal of cell science 2004 Oct 15;117(Pt 22):5245-56
Journal of cell science 2004 Oct 15;117(Pt 22):5245-56
Isoforms of the polarity protein par6 have distinct functions.
Gao L, Macara IG
The Journal of biological chemistry 2004 Oct 1;279(40):41557-62
The Journal of biological chemistry 2004 Oct 1;279(40):41557-62
Association of connexin36 with zonula occludens-1 in HeLa cells, betaTC-3 cells, pancreas, and adrenal gland.
Li X, Olson C, Lu S, Nagy JI
Histochemistry and cell biology 2004 Nov;122(5):485-98
Histochemistry and cell biology 2004 Nov;122(5):485-98
The rotavirus surface protein VP8 modulates the gate and fence function of tight junctions in epithelial cells.
Nava P, López S, Arias CF, Islas S, González-Mariscal L
Journal of cell science 2004 Nov 1;117(Pt 23):5509-19
Journal of cell science 2004 Nov 1;117(Pt 23):5509-19
Activin A and follicle-stimulating hormone control tight junctions in avian granulosa cells by regulating occludin expression.
Schuster MK, Schmierer B, Shkumatava A, Kuchler K
Biology of reproduction 2004 May;70(5):1493-9
Biology of reproduction 2004 May;70(5):1493-9
Endothelia of Schlemm's canal and trabecular meshwork: distinct molecular, functional, and anatomic features.
Alvarado JA, Betanzos A, Franse-Carman L, Chen J, González-Mariscal L
American journal of physiology. Cell physiology 2004 Mar;286(3):C621-34
American journal of physiology. Cell physiology 2004 Mar;286(3):C621-34
A novel four transmembrane spanning protein, CLP24. A hypoxically regulated cell junction protein.
Kearsey J, Petit S, De Oliveira C, Schweighoffer F
European journal of biochemistry 2004 Jul;271(13):2584-92
European journal of biochemistry 2004 Jul;271(13):2584-92
Characterization of the tight junction protein ZO-2 localized at the nucleus of epithelial cells.
Jaramillo BE, Ponce A, Moreno J, Betanzos A, Huerta M, Lopez-Bayghen E, Gonzalez-Mariscal L
Experimental cell research 2004 Jul 1;297(1):247-58
Experimental cell research 2004 Jul 1;297(1):247-58
Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment.
Ivanov AI, Nusrat A, Parkos CA
Molecular biology of the cell 2004 Jan;15(1):176-88
Molecular biology of the cell 2004 Jan;15(1):176-88
Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells.
Singh AB, Harris RC
The Journal of biological chemistry 2004 Jan 30;279(5):3543-52
The Journal of biological chemistry 2004 Jan 30;279(5):3543-52
Identification of PKCzetaII: an endogenous inhibitor of cell polarity.
Parkinson SJ, Le Good JA, Whelan RD, Whitehead P, Parker PJ
The EMBO journal 2004 Jan 14;23(1):77-88
The EMBO journal 2004 Jan 14;23(1):77-88
Oxidative stress affects the junctional integrity of retinal pigment epithelial cells.
Bailey TA, Kanuga N, Romero IA, Greenwood J, Luthert PJ, Cheetham ME
Investigative ophthalmology & visual science 2004 Feb;45(2):675-84
Investigative ophthalmology & visual science 2004 Feb;45(2):675-84
Oxidative stress affects the junctional integrity of retinal pigment epithelial cells.
Bailey TA, Kanuga N, Romero IA, Greenwood J, Luthert PJ, Cheetham ME
Investigative ophthalmology & visual science 2004 Feb;45(2):675-84
Investigative ophthalmology & visual science 2004 Feb;45(2):675-84
Mechanism of recruiting Sec6/8 (exocyst) complex to the apical junctional complex during polarization of epithelial cells.
Yeaman C, Grindstaff KK, Nelson WJ
Journal of cell science 2004 Feb 1;117(Pt 4):559-70
Journal of cell science 2004 Feb 1;117(Pt 4):559-70
Expression and function of tight junctions in the crypt epithelium of human palatine tonsils.
Go M, Kojima T, Takano K, Murata M, Ichimiya S, Tsubota H, Himi T, Sawada N
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004 Dec;52(12):1627-38
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004 Dec;52(12):1627-38
Histone deacetylase inhibitors up-regulate the expression of tight junction proteins.
Bordin M, D'Atri F, Guillemot L, Citi S
Molecular cancer research : MCR 2004 Dec;2(12):692-701
Molecular cancer research : MCR 2004 Dec;2(12):692-701
Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium.
Acharya P, Beckel J, Ruiz WG, Wang E, Rojas R, Birder L, Apodaca G
American journal of physiology. Renal physiology 2004 Aug;287(2):F305-18
American journal of physiology. Renal physiology 2004 Aug;287(2):F305-18
Tight junction-associated proteins (occludin, ZO-1, claudin-1, claudin-4) in squamous cell carcinoma and Bowen's disease.
Morita K, Tsukita S, Miyachi Y
The British journal of dermatology 2004 Aug;151(2):328-34
The British journal of dermatology 2004 Aug;151(2):328-34
Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1.
Li X, Olson C, Lu S, Kamasawa N, Yasumura T, Rash JE, Nagy JI
The European journal of neuroscience 2004 Apr;19(8):2132-46
The European journal of neuroscience 2004 Apr;19(8):2132-46
The specific fates of tight junction proteins in apoptotic epithelial cells.
Bojarski C, Weiske J, Schöneberg T, Schröder W, Mankertz J, Schulzke JD, Florian P, Fromm M, Tauber R, Huber O
Journal of cell science 2004 Apr 15;117(Pt 10):2097-107
Journal of cell science 2004 Apr 15;117(Pt 10):2097-107
Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells.
Shingai T, Ikeda W, Kakunaga S, Morimoto K, Takekuni K, Itoh S, Satoh K, Takeuchi M, Imai T, Monden M, Takai Y
The Journal of biological chemistry 2003 Sep 12;278(37):35421-7
The Journal of biological chemistry 2003 Sep 12;278(37):35421-7
Role of claudin interactions in airway tight junctional permeability.
Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG
American journal of physiology. Lung cellular and molecular physiology 2003 Nov;285(5):L1166-78
American journal of physiology. Lung cellular and molecular physiology 2003 Nov;285(5):L1166-78
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells.
Anders M, Christian C, McMahon M, McCormick F, Korn WM
Cancer research 2003 May 1;63(9):2088-95
Cancer research 2003 May 1;63(9):2088-95
Role of catenins in the development of gap junctions in rat cardiomyocytes.
Wu JC, Tsai RY, Chung TH
Journal of cellular biochemistry 2003 Mar 1;88(4):823-35
Journal of cellular biochemistry 2003 Mar 1;88(4):823-35
The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.
Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y
Molecular biology of the cell 2003 Jun;14(6):2520-9
Molecular biology of the cell 2003 Jun;14(6):2520-9
Nectin-dependent localization of ZO-1 at puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 area of adult mouse hippocampus.
Inagaki M, Irie K, Deguchi-Tawarada M, Ikeda W, Ohtsuka T, Takeuchi M, Takai Y
The Journal of comparative neurology 2003 Jun 9;460(4):514-24
The Journal of comparative neurology 2003 Jun 9;460(4):514-24
Age-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1).
Mooradian AD, Haas MJ, Chehade JM
Mechanisms of ageing and development 2003 Feb;124(2):143-6
Mechanisms of ageing and development 2003 Feb;124(2):143-6
Age-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1).
Mooradian AD, Haas MJ, Chehade JM
Mechanisms of ageing and development 2003 Feb;124(2):143-6
Mechanisms of ageing and development 2003 Feb;124(2):143-6
Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.
Brown RC, Mark KS, Egleton RD, Huber JD, Burroughs AR, Davis TP
Journal of cell science 2003 Feb 15;116(Pt 4):693-700
Journal of cell science 2003 Feb 15;116(Pt 4):693-700
Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.
Brown RC, Mark KS, Egleton RD, Huber JD, Burroughs AR, Davis TP
Journal of cell science 2003 Feb 15;116(Pt 4):693-700
Journal of cell science 2003 Feb 15;116(Pt 4):693-700
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins.
Van Itallie CM, Fanning AS, Anderson JM
American journal of physiology. Renal physiology 2003 Dec;285(6):F1078-84
American journal of physiology. Renal physiology 2003 Dec;285(6):F1078-84
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms.
Bruewer M, Luegering A, Kucharzik T, Parkos CA, Madara JL, Hopkins AM, Nusrat A
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 1;171(11):6164-72
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 1;171(11):6164-72
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms.
Bruewer M, Luegering A, Kucharzik T, Parkos CA, Madara JL, Hopkins AM, Nusrat A
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 1;171(11):6164-72
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 1;171(11):6164-72
Immunohistological distribution of the tight junction components ZO-1 and occludin in regenerating human epidermis.
Malminen M, Koivukangas V, Peltonen J, Karvonen SL, Oikarinen A, Peltonen S
The British journal of dermatology 2003 Aug;149(2):255-60
The British journal of dermatology 2003 Aug;149(2):255-60
Immunohistological distribution of the tight junction components ZO-1 and occludin in regenerating human epidermis.
Malminen M, Koivukangas V, Peltonen J, Karvonen SL, Oikarinen A, Peltonen S
The British journal of dermatology 2003 Aug;149(2):255-60
The British journal of dermatology 2003 Aug;149(2):255-60
Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in the Caco-2 cell monolayer.
Basuroy S, Sheth P, Kuppuswamy D, Balasubramanian S, Ray RM, Rao RK
The Journal of biological chemistry 2003 Apr 4;278(14):11916-24
The Journal of biological chemistry 2003 Apr 4;278(14):11916-24
2,3-butanedione monoxime (BDM), a potent inhibitor of actin-myosin interaction, induces ion and fluid transport in MDCK monolayers.
Castillo AM, Reyes JL, Sánchez E, Mondragón R, Meza I
Journal of muscle research and cell motility 2002;23(3):223-34
Journal of muscle research and cell motility 2002;23(3):223-34
2,3-butanedione monoxime (BDM), a potent inhibitor of actin-myosin interaction, induces ion and fluid transport in MDCK monolayers.
Castillo AM, Reyes JL, Sánchez E, Mondragón R, Meza I
Journal of muscle research and cell motility 2002;23(3):223-34
Journal of muscle research and cell motility 2002;23(3):223-34
Applications of epithelial cell culture in studies of drug transport.
Tavelin S, Gråsjö J, Taipalensuu J, Ocklind G, Artursson P
Methods in molecular biology (Clifton, N.J.) 2002;188:233-72
Methods in molecular biology (Clifton, N.J.) 2002;188:233-72
Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells.
Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E
The Journal of cell biology 2002 Oct 28;159(2):361-72
The Journal of cell biology 2002 Oct 28;159(2):361-72
Diabetes-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1) expression.
Chehade JM, Haas MJ, Mooradian AD
Neurochemical research 2002 Mar;27(3):249-52
Neurochemical research 2002 Mar;27(3):249-52
Diabetes-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1) expression.
Chehade JM, Haas MJ, Mooradian AD
Neurochemical research 2002 Mar;27(3):249-52
Neurochemical research 2002 Mar;27(3):249-52
Hepatocyte polarity and the peroxisomal compartment: a comparative study.
Depreter M, Walker T, De Smet K, Beken S, Kerckaert I, Rogiers V, Roels F
The Histochemical journal 2002 Mar-Apr;34(3-4):139-51
The Histochemical journal 2002 Mar-Apr;34(3-4):139-51
E-Cadherin and tight junctions between epithelial cells of different animal species.
Contreras RG, Shoshani L, Flores-Maldonado C, Lázaro A, Monroy AO, Roldán ML, Fiorentino R, Cereijido M
Pflugers Archiv : European journal of physiology 2002 Jul;444(4):467-75
Pflugers Archiv : European journal of physiology 2002 Jul;444(4):467-75
Tight junctions are sensitive to peptides eliminated in the urine.
Gallardo JM, Hernández JM, Contreras RG, Flores-Maldonado C, González-Mariscal L, Cereijido M
The Journal of membrane biology 2002 Jul 1;188(1):33-42
The Journal of membrane biology 2002 Jul 1;188(1):33-42
Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways.
Janda E, Lehmann K, Killisch I, Jechlinger M, Herzig M, Downward J, Beug H, Grünert S
The Journal of cell biology 2002 Jan 21;156(2):299-313
The Journal of cell biology 2002 Jan 21;156(2):299-313
JEAP, a novel component of tight junctions in exocrine cells.
Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y, Imai T, Takai Y
The Journal of biological chemistry 2002 Feb 15;277(7):5583-7
The Journal of biological chemistry 2002 Feb 15;277(7):5583-7
Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin.
Govindarajan R, Zhao S, Song XH, Guo RJ, Wheelock M, Johnson KR, Mehta PP
The Journal of biological chemistry 2002 Dec 20;277(51):50087-97
The Journal of biological chemistry 2002 Dec 20;277(51):50087-97
cAMP-dependent protein kinase and proliferation differ in normal and polycystic kidney epithelia.
Marfella-Scivittaro C, Quiñones A, Orellana SA
American journal of physiology. Cell physiology 2002 Apr;282(4):C693-707
American journal of physiology. Cell physiology 2002 Apr;282(4):C693-707
Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions.
Nishiyama R, Sakaguchi T, Kinugasa T, Gu X, MacDermott RP, Podolsky DK, Reinecker HC
The Journal of biological chemistry 2001 Sep 21;276(38):35571-80
The Journal of biological chemistry 2001 Sep 21;276(38):35571-80
Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes.
Pummi K, Malminen M, Aho H, Karvonen SL, Peltonen J, Peltonen S
The Journal of investigative dermatology 2001 Nov;117(5):1050-8
The Journal of investigative dermatology 2001 Nov;117(5):1050-8
Long-term natural culture of cochlear sensory epithelia of guinea pigs.
Zhao HB
Neuroscience letters 2001 Nov 23;315(1-2):73-6
Neuroscience letters 2001 Nov 23;315(1-2):73-6
Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells.
Yeaman C, Grindstaff KK, Wright JR, Nelson WJ
The Journal of cell biology 2001 Nov 12;155(4):593-604
The Journal of cell biology 2001 Nov 12;155(4):593-604
Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression.
Huber JD, Witt KA, Hom S, Egleton RD, Mark KS, Davis TP
American journal of physiology. Heart and circulatory physiology 2001 Mar;280(3):H1241-8
American journal of physiology. Heart and circulatory physiology 2001 Mar;280(3):H1241-8
Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression.
Huber JD, Witt KA, Hom S, Egleton RD, Mark KS, Davis TP
American journal of physiology. Heart and circulatory physiology 2001 Mar;280(3):H1241-8
American journal of physiology. Heart and circulatory physiology 2001 Mar;280(3):H1241-8
Integrity of epithelium and endothelium in organ-cultured human corneas.
Crewe JM, Armitage WJ
Investigative ophthalmology & visual science 2001 Jul;42(8):1757-61
Investigative ophthalmology & visual science 2001 Jul;42(8):1757-61
Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.
Pálmer HG, González-Sancho JM, Espada J, Berciano MT, Puig I, Baulida J, Quintanilla M, Cano A, de Herreros AG, Lafarga M, Muñoz A
The Journal of cell biology 2001 Jul 23;154(2):369-87
The Journal of cell biology 2001 Jul 23;154(2):369-87
Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.
Pálmer HG, González-Sancho JM, Espada J, Berciano MT, Puig I, Baulida J, Quintanilla M, Cano A, de Herreros AG, Lafarga M, Muñoz A
The Journal of cell biology 2001 Jul 23;154(2):369-87
The Journal of cell biology 2001 Jul 23;154(2):369-87
The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction.
Nusrat A, Chen JA, Foley CS, Liang TW, Tom J, Cromwell M, Quan C, Mrsny RJ
The Journal of biological chemistry 2000 Sep 22;275(38):29816-22
The Journal of biological chemistry 2000 Sep 22;275(38):29816-22
Saccharomyces boulardii preserves the barrier function and modulates the signal transduction pathway induced in enteropathogenic Escherichia coli-infected T84 cells.
Czerucka D, Dahan S, Mograbi B, Rossi B, Rampal P
Infection and immunity 2000 Oct;68(10):5998-6004
Infection and immunity 2000 Oct;68(10):5998-6004
Molecular physiology and pathophysiology of tight junctions III. Tight junction regulation by intracellular messengers: differences in response within and between epithelia.
Karczewski J, Groot J
American journal of physiology. Gastrointestinal and liver physiology 2000 Oct;279(4):G660-5
American journal of physiology. Gastrointestinal and liver physiology 2000 Oct;279(4):G660-5
Potential biological role of transforming growth factor-beta1 in human congenital kidney malformations.
Yang SP, Woolf AS, Yuan HT, Scott RJ, Risdon RA, O'Hare MJ, Winyard PJ
The American journal of pathology 2000 Nov;157(5):1633-47
The American journal of pathology 2000 Nov;157(5):1633-47
Potential biological role of transforming growth factor-beta1 in human congenital kidney malformations.
Yang SP, Woolf AS, Yuan HT, Scott RJ, Risdon RA, O'Hare MJ, Winyard PJ
The American journal of pathology 2000 Nov;157(5):1633-47
The American journal of pathology 2000 Nov;157(5):1633-47
Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology.
Ryeom SW, Paul D, Goodenough DA
Molecular biology of the cell 2000 May;11(5):1687-96
Molecular biology of the cell 2000 May;11(5):1687-96
Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology.
Ryeom SW, Paul D, Goodenough DA
Molecular biology of the cell 2000 May;11(5):1687-96
Molecular biology of the cell 2000 May;11(5):1687-96
Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells.
Chen Yh, Lu Q, Schneeberger EE, Goodenough DA
Molecular biology of the cell 2000 Mar;11(3):849-62
Molecular biology of the cell 2000 Mar;11(3):849-62
Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells.
Chen Yh, Lu Q, Schneeberger EE, Goodenough DA
Molecular biology of the cell 2000 Mar;11(3):849-62
Molecular biology of the cell 2000 Mar;11(3):849-62
Tight junction proteins ZO-1, ZO-2, and occludin along isolated renal tubules.
Gonzalez-Mariscal L, Namorado MC, Martin D, Luna J, Alarcon L, Islas S, Valencia L, Muriel P, Ponce L, Reyes JL
Kidney international 2000 Jun;57(6):2386-402
Kidney international 2000 Jun;57(6):2386-402
A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation.
Adams LD, Lemire JM, Schwartz SM
Arteriosclerosis, thrombosis, and vascular biology 1999 Nov;19(11):2600-8
Arteriosclerosis, thrombosis, and vascular biology 1999 Nov;19(11):2600-8
Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas.
Mann B, Gelos M, Siedow A, Hanski ML, Gratchev A, Ilyas M, Bodmer WF, Moyer MP, Riecken EO, Buhr HJ, Hanski C
Proceedings of the National Academy of Sciences of the United States of America 1999 Feb 16;96(4):1603-8
Proceedings of the National Academy of Sciences of the United States of America 1999 Feb 16;96(4):1603-8
Relationship between Na(+),K(+)-ATPase and cell attachment.
Contreras RG, Shoshani L, Flores-Maldonado C, Lázaro A, Cereijido M
Journal of cell science 1999 Dec;112 ( Pt 23):4223-32
Journal of cell science 1999 Dec;112 ( Pt 23):4223-32
Relationship between Na(+),K(+)-ATPase and cell attachment.
Contreras RG, Shoshani L, Flores-Maldonado C, Lázaro A, Cereijido M
Journal of cell science 1999 Dec;112 ( Pt 23):4223-32
Journal of cell science 1999 Dec;112 ( Pt 23):4223-32
Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin.
Cordenonsi M, D'Atri F, Hammar E, Parry DA, Kendrick-Jones J, Shore D, Citi S
The Journal of cell biology 1999 Dec 27;147(7):1569-82
The Journal of cell biology 1999 Dec 27;147(7):1569-82
Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin.
Cordenonsi M, D'Atri F, Hammar E, Parry DA, Kendrick-Jones J, Shore D, Citi S
The Journal of cell biology 1999 Dec 27;147(7):1569-82
The Journal of cell biology 1999 Dec 27;147(7):1569-82
ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin.
Haskins J, Gu L, Wittchen ES, Hibbard J, Stevenson BR
The Journal of cell biology 1998 Apr 6;141(1):199-208
The Journal of cell biology 1998 Apr 6;141(1):199-208
ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin.
Haskins J, Gu L, Wittchen ES, Hibbard J, Stevenson BR
The Journal of cell biology 1998 Apr 6;141(1):199-208
The Journal of cell biology 1998 Apr 6;141(1):199-208
Occludin confers adhesiveness when expressed in fibroblasts.
Van Itallie CM, Anderson JM
Journal of cell science 1997 May;110 ( Pt 9):1113-21
Journal of cell science 1997 May;110 ( Pt 9):1113-21
Occludin confers adhesiveness when expressed in fibroblasts.
Van Itallie CM, Anderson JM
Journal of cell science 1997 May;110 ( Pt 9):1113-21
Journal of cell science 1997 May;110 ( Pt 9):1113-21
Manganese and other trace elements in urban snow near an expressway.
Loranger S, Tétrault M, Kennedy G, Zayed J
Environmental pollution (Barking, Essex : 1987) 1996;92(2):203-11
Environmental pollution (Barking, Essex : 1987) 1996;92(2):203-11
The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell-cell contacts.
Gottardi CJ, Arpin M, Fanning AS, Louvard D
Proceedings of the National Academy of Sciences of the United States of America 1996 Oct 1;93(20):10779-84
Proceedings of the National Academy of Sciences of the United States of America 1996 Oct 1;93(20):10779-84
The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.
Willott E, Balda MS, Fanning AS, Jameson B, Van Itallie C, Anderson JM
Proceedings of the National Academy of Sciences of the United States of America 1993 Aug 15;90(16):7834-8
Proceedings of the National Academy of Sciences of the United States of America 1993 Aug 15;90(16):7834-8
The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.
Willott E, Balda MS, Fanning AS, Jameson B, Van Itallie C, Anderson JM
Proceedings of the National Academy of Sciences of the United States of America 1993 Aug 15;90(16):7834-8
Proceedings of the National Academy of Sciences of the United States of America 1993 Aug 15;90(16):7834-8
Two classes of tight junctions are revealed by ZO-1 isoforms.
Balda MS, Anderson JM
The American journal of physiology 1993 Apr;264(4 Pt 1):C918-24
The American journal of physiology 1993 Apr;264(4 Pt 1):C918-24
Two classes of tight junctions are revealed by ZO-1 isoforms.
Balda MS, Anderson JM
The American journal of physiology 1993 Apr;264(4 Pt 1):C918-24
The American journal of physiology 1993 Apr;264(4 Pt 1):C918-24
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- Western blot analysis of Caco-2 cell lysates using Rb anti-ZO-1 (Product # 61-7300).
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- Western blot analysis of ZO-1 expression in the human colon cancer cell line CACO-2 using Rb x ZO-1.
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- Western blot analysis of ZO-1 expression in MDCK cells using Rb x ZO-1.
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- Immunofluorescent analysis of ZO-1 (green) in Caco-2 cells. The cells were fixed with 4% paraformaldehyde for 15 minutes and blocked with 3% Blocker BSA (Product # 37525) in PBS for 15 minutes at room temperature. Cells were stained with or without ZO-1 rabbit polyclonal antibody (Product # 61-7300), at a concentration of 5 µg/mL for 1 hour at room temperature, and then incubated with a Goat anti-Rabbit IgG (H+L) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034) at a dilution of 1:1000 for 1 hour at room temperature (both panels, green). Nuclei (both panels, blue) were stained with Hoechst 33342 dye (Product # 62249). Images were taken on a Thermo Scientific ToxInsight at 20X magnification.
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- Indirect immunofluorescence staining of rat glomerulus using Zymed (R) Rb anti-ZO-1 (Product # 61-7300) (red). Image courtesy of Hidetake Kurihara, PhD, Juntendo University School of Medicine, Tokyo, Japan.
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- Immunohistochemical analysis of ZO-1 in small intestine using a polyclonal antibody (Product # 61-7300).
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- Figure 6 Expression of cell junction and Bcl-2 signaling proteins in NCI-H226 monolayers and spheroids. A . Protein expression of E-Cadherin, ZO-1, Connexin-32, Mcl-1, Bcl-xL, Bid, Bak, Bax, and beta-actin examined by Western blot. B . Molecular mechanisms underlying drug resistance in tumor spheroids.
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- FIGURE 10: Overexpression of either GFP-Rab11-FIP2-WT or GFP-Rab11-FIP2 (S227E) altered the claudin content of tight junctions. GFP-Rab11-FIP2-WT-on and GFP-Rab11-FIP2(S227E)-on and -off were grown for 5 d postconfluence on Transwell filters. The cells were fixed then stained for claudin-1 (A), claudin-2 (B), or claudin-4 (C) and ZO-1. In the merged image, GFP-Rab11-FIP2s are pseudocolored green, the claudins are red, and ZO-1 is blue. (D) Cells were grown as described, then lysed, run on Western blots, and probed for the different claudins and VDAC. Three separate blots were scanned and quantified using ImageJ and normalized to control (VDAC). *p
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- FIGURE 6: Rab25 depletion alters the transepithelial resistance and claudin expression. (A) TER was measured in all cell lines from day 3 to day 15 on Transwell filters. During this period, the media were changed every day, and TER was measured in 24-well Transwell inserts. Results are expressed in ohm-cm 2 and are representative of three separate experiments. (B) Equal amounts of total protein lysates (20 mug) from Control, Rab25KD, and Rescue cells were analyzed by Western blots for tight junction proteins. The blots were subsequently stripped and reprobed for beta-actin as a loading control. The results are representative of three separate experiments.
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- Figure 2 Cldn6 induces the formation of cell-cell junctions and apicobasal cell polarity in F9 stem cells. (A and D) X-Y and Z projections of F9:Cldn6 cells stained for Cldn6 together with the tight-junction markers (Cldn7, Ocln, ZO-1, and ZO-1alpha+ variant), the basolateral maker (E-Cad), and the apical markers (ezrin, radixin, and EBP50). The arrowhead indicates the recruitment of Ocln to a part of Cldn6-positive premmature cell-cell junctions. The asterisk shows the absence of EBP50 on the apical surfaces of undifferentiated cells possessing Cldn6-positive premature cell-cell junctions. Scale bars, 20 um. (B) Confocal images of undifferentiated areas of F9:Cldn6 cells stained for Cldn6 together with Ocln. The arrowheads indicate the partial recruitment of Ocln to Cldn6-positive cell borders of undifferentiated cells. Scale bar, 20 um. (C) Confocal images of F9:Cldn6 cells stained for Cldn6 together with Cldn4 and DAPI. Scale bar, 20 um.
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- Figure 3 The expression of tight junction mRNA and proteins in Caco-2 EP2 receptor transfectants. (A) The mRNA expression for tight junction proteins (ZO-1, occludin, claudin-1, claudin-2 and claudin-4) in Caco-2 EP2S and EP2A cells was measured by Q-PCR. The expression of gene of interest (GOI) was normalized with the internal control (Actin) and expressed as fold changes with that of the vector control. (B) A representative immunoblot showing constitutive expression of the important tight junction proteins (ZO-1, occludin, claudin-1, claudin-2 and claudin-4) in EP2S, EP2A and vector control cells. Actin used as internal control. (C) Densitometry analysis for claudin-4 expression in EP2S, EP2A and vector control cells. EP2A compared statistically with the vector control. p
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- Figure 5 Effects of suppression of cofilin activation or overexpresssion of TJ proteins on the capsaicin-induced cofilin dephosphorylation and decrease in occludin expression. (A-C) Flag-HA tagged cofilin and LIMK, and EGFP-occludin and claudin-1 stable transfectants were established. Monolayers prepared from the transfectants and non-transfected MDCK cells were exposed to 300 uM capsaicin for the time indicated. After lysis, protein expression was analyzed by immunoblotting. Each experiment was performed with at least two different clones and repeated at least twice. (D) MDCK monolayers were pretreated with vehicle or 50 uM TFP for 30 min, and then exposed to 100 uM capsaicin for the time indicated. The levels of occludin and phospho-cofilin were analyzed by western blotting.
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- Figure 3 Effects of capsaicin on the distribution of TJ proteins and F-actin. (A, B) Monolayers were exposed to vehicle (A) or 300 uM capsaicin (B) for 45 min and were labeled with each TJ antibody (green), rhodamine-phalloidin (red) and Hoechst (blue). Images were collected as a Z-series, and then deconvoluted and overlayed to display a single composite projection. Top : XY sections of merged images. Bottom : XZ sections of merged images. Scale bar: 10 um. The corresponding TJ antibodies are listed above the images. (C) 3D projection images in a 45deg-angle of claudin-1 and tricellulin staining, plus F-actin. Scale bar: 10 um. (D) MDCK monolayers exposed to vehicle (top) or capsaicin (bottom) as above were stained with E-cadherin. The colors corresponding to each antibody are listed above the images. Scale bar: 2.5 um. (E) Schematic explanation of the protein distributions.
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- Fig. 2 Phenotype and irreversible de-differentiation of Immortomouse (r) CPECs. a Primary Immortomouse (r) choroid plexus epithelial cells (p0) grown at 37 degC for 7 days showed the same staining patterns for cytokeratin (CK) and claudin-1 (Cldn-1) as pmCPECs isolated from wild-type mice. b When Immortomouse (r) CPECs were grown under permissive conditions (33 degC, 10U IFNgamma) the heterogenous de-differentiation process started in areas with low cell density, whereas CPECs kept their cuboidal shape longer in areas with high cell density. The contrast of the pictures in a and b was enhanced using Adobe Photoshop software. c Vimentin staining, rather than CK staining was observed at 33 degC. Cell death took place at 33 degC upon Ara-C addition to culture. d The irreversible loss of CPEC specific markers Cldn-1 and CK and an increasing proliferation rate of de-differentiated Immortomouse (r) CPECs was observed with increased passage. The first row is passage 2 (p2), the second row is p3, the third row is p4. e The cells failed to form confluent monolayers or display the correct expression pattern of epithelial markers upon shift to non-permissive temperature and IFNgamma withdrawal. Immortomouse (r) CPECs in e were stained after 7 days of non-permissive growth; the passage numbers (p) were E-cad/DAPI: p8, ZO1/beta-Cat/DAPI: p5, Cldn11/N-Cad/DAPI: p6, Cldn-1/CK/DAPI: p4. Scale bar in all immunofluorescent and phase contrast pictures = 100 mum. p0 primary culture, E-Cad E-cadh
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- Fig. 4 Phenotype of ECPC4 cells and primary mouse choroid plexus epithelial cells (pmCPECs). Immunofluorescence staining for CPEC specific proteins is shown in ECPC4 cells ( a ) and pmCPECs ( b ). a There is weak staining for the adhesion junction (AJ) protein E-Cadherin (E-Cad) and its cytoskeleton linker beta-catenin (beta-Cat) of ECPC4 cells and their localization is not specifically at the plasma membrane. Staining for tight junctional (TJ) claudins-1 and -11 was absent or showed a weak cytosolic pattern, respectively. The scaffolding protein ZO1 staining was disrupted. Additionally, the cell line failed to stain for the early epithelial marker cytokeratin but rather was positive for the mesenchymal intermediate filament protein vimentin. ECPC4 cells from passage 41 were stained on d4 in culture. b In contrast, the staining of pmCPECs stained on d7 in culture, revealed a proper distribution of all epithelial markers. pmCPECs. All staining was performed at least 3 times. Scale bars 50 mum. E-Cad E-cadherin, Cldn-1 Claudin 1, Cldn-11 claudin 11, CK cytokeratin, beta-Cat beta-catenin, ZO-1 zona occludens protein 1
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- Figure 5 Overexpression of DPT in the Sertoli cells reduces the expression levels of ZO-1 and claudin-11 in the testes. (A) Representative western blotting analyses of ZO-1 and claudin-11 in the control mice and the mice with DPT overexpression. (B) The relative expression levels of ZO-1 and claudin-11 were determined using densitometric analysis of the data normalized against the beta-actin from five different samples. The data are presented as the mean +- standard error of the mean ( a P
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- Figure 1 XIST expression in GECs and XIST regulated BTB permeability, glioma angiogenesis, tight junction-related proteins and CXCR7 expression. ( a ) Relative XIST expression in ECs and GECs by real-time qPCR. Data represent mean+-s.d. ( n =5, each). * P
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- Figure 3 miR-137 mediated the effects of XIST knockdown on GECs. ( a ) TEER assay to evaluate the effect of XIST and miR-137 on BTB integrity. ( b ) HRP flux assay to evaluate the effect of XIST and miR-137 on BTB permeability. ( c ) Cell Counting Kit-8 (CCK-8) assay to evaluate the effect of XIST and miR-137 on GECs proliferation. ( d ) Transwell assay to evaluate the effect of XIST and miR-137 on GECs migration. ( e ) Matrigel tube formation assay to evaluate the effect of XIST and miR-137 on GECs tube formation. ( f ) Western blot assay to evaluate the effect of XIST and miR-137 on tight junction-related proteins. ( g ) Western blot assay to evaluate the effect of XIST and miR-137 on CXCR7. Data represent mean+-s.d. ( n =5, each). * P
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- Figure 4 miR-137 expression in GECs and miR-137 regulated BTB permeability, glioma angiogenesis, tight junction-related proteins and CXCR7 expression. ( a ) Relative miR-137 expression in ECs and GECs by real-time quantitative PCR. Data represent mean+-s.d. ( n =5, each). * P
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- FIG. 4 Verification of a functional endothelial cell monolayer. A The endothelial cells are double labeled for the tight junction protein ZO-1 ( green ) and nuclei ( blue ). B The endothelial cells are double labeled for the tight junction protein VE-cadherin ( green ) and nuclei ( blue ). C FITC-dextran fluorescence intensity is shown at different time points. The endothelial cell monolayer is established by day 5.
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- Figure 3 MMP13 contributes to tight junction destabilization Source data is available for this figure in the Supporting Information. A-C. Western blot quantification of the protein expression levels of ZO-1 (A), occludin (B) and claudin (C) in mucosal scrapings of ilea from MMP13 +/+ (black) and MMP13 -/- (grey) mice 0 and 8 h after LPS injection ( n = 3-4). D,E. Representative ZO-1 immunogold-labeled TEM images of MMP13 +/+ (D) and MMP13 -/- (E) mice 8 h after LPS injection. F. Schematic overview of the separation of the lipid raft and non-lipid-raft fractions by ultracentrifugation. G. Caveolin-1 western blot analysis of fractions obtained after ultracentrifugation of mucosal scrapings from MMP13 +/+ and MMP13 -/- mice 0 and 8 h after LPS challenge.
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- Figure 4 Capsaicin decreases occludin protein content and the protein-protein interactions involving occludin in TJ. (A,B) MDCK monolayers were exposed to ethanol control or 300 uM capsaicin for 45 min. (A) The cellular localization of the TJ proteins occludin and claudin-1 was examined by immunofluorescence. Scale bar: 10 um. (B) Western blot detection of occludin, tricellulin, Zo-1, claudin-1, E-cadherin and actin in the cytosol, membrane fractions and total cell extracts. The densitometic analysis of total proteins from three independent experiments performed with NIH ImageJ software. **represents p
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- Fig. 3. TJ components detected in cultured RCE1(5T5) corneal epithelial cells. This was performed either by: ( A-J ) immunostaining, ( K-M ) end point RT-PCR, or ( N ) Western blot. (A) We used alpha-catenin as an indicator of the presence of adhesion complexes in the cultured epithelia. (B,G) Ocln, (D) ZO-1, (E) cldn-1, (C,I) cldn-4, and (F,H) cgn were easily located in cell borders of one day post-confluent cultures. (G-I) are transverse sections showing that TJs (arrows) were located at the cell boundaries of suprabasal cells. In (G), dashed line indicates the boundaries between a suprabasal cell and the basal cell layer; in (H-J) the dashed line indicate the basal side of the epithelium. Nuclei were stained either with propidium iodide or TO-PRO(r)-3. In 7-day confluent epithelia we found (K) the expression of cldn-1, -2, -4, but not of cldn-3 and -7; (L) cgn, ocln, and (M) ZO-1. Primers for cldn-3 and -7 were verified in PCR reactions using mouse kidney cDNA (K, m-kidney) that led to amplification products of the expected size and sequence. PR-P0 was used as an internal marker that does not change during the differentiation process. The antibodies were only appropriate to immunodetect cldn-1 and -4 and cgn (N); lanes 2 and 3 correspond to the loading control for the experiment. PCR reaction in the presence (+) or the absence of cDNA (-) (negative control). Results correspond to six duplicated experiments. A-D: Bar = 20 mum; E,F: Bar = 40 mum; G: Bar = 8 mum, and H-J: Bar
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- Figure 5 Knockdown of Rai14 in the Sertoli cell epithelium with an established TJ-permeability barrier in vitro by RNAi disrupts actin filament organization and the TJ barrier. (A) Sertoli cells cultured alone on Matrigel-coated 12-well dishes for 2-day with an established TJ-permeability barrier were transfected with Rai14 siRNA duplexes (Rai14 RNAi) versus non-targeting control duplexes (Ctrl RNAi) at 100 nM using Ribojuice transfection medium for 24 hr, thereafter, cells were washed twice and cultured in F12/DMEM for 12 hr to allow recovery. Thereafter, cells were transfected again under the same conditions for another 24 hr. Thereafter, cells were rinsed with fresh F12/DMEM and cultured for an additional 12 hr before termination, and used to prepare lysates for immunoblotting using antibodies against several BTB-associated constituent or regulatory proteins. A knockdown of Rai14 by ~50% was noted in which the control was arbitrarily set at 1 against which statistical comparison was performed (B) without any apparent off-target effects (A). The findings shown herein are the results of 3 independent experiments excluding pilot experiments which were used to establish optimal experimental conditions, such as different concentrations of siRNA duplexes and Ribojuice. It was noted that we achieved only ~50-60% knockdown of Rai14 in several pilot experiments, unlike other target genes [ e.g ., Scribble, beta1-integrin, and P-glycoprotein] wherein we could silence the target gene
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- Figure 1 Rai14 is an actin-binding protein in the rat testis. ( A ) A study by RT-PCR to confirm the expression of Rai14 in adult rat testis, Sertoli cells (SC, isolated from 20-day-old rat testes and cultured for 4-day), and germ cells (GC, isolated from adult rat testes and cultured for 16 hr). ( B ) Immunoblotting also confirmed the expression of Rai14 in the rat testis, Sertoli and germ cells, and the relative expression of Rai14 in SC vs. GC was shown in the histogram with n = 3 experiments in which the relative expression level of Rai14 in the testis was arbitrarily set at 1 so that the relative expression level between these samples can be compared. ( C ) The specificity of the anti-Rai14 antibody ( Table 1 ) was assessed by immunoblotting using lysates of GC (20 ug protein). ( D ) Using the specific anti-Rai14 antibody, Rai14 was shown to be an actin-binding protein by co-immunoprecipitation (Co-IP); however, Rai14 did not structurally interact with any of the BTB-associated proteins including several actin-binding and regulatory proteins ( e.g ., Arp3, drebrin E, Eps8) and vimentin (an intermediate filament-based constituent protein). However, Rai14 was found to structurally interact with an actin cross-linking protein palladin which is known to be involved in conferring actin filament bundles in other mammalian cells [48] . ( E ) Rai14 (red) was also shown to be an actin-binding protein by dual-labeled immunofluorescence analysis in which it co-localized with F-acti
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- Figure 3 Confocal analysis of brush border and trafficking defects in Munc18-2 KO organoids . ( A ) Defective deposition of brush-border F-actin as shown by phalloidin staining (red). Zonula occludens-1 (ZO-1) co-staining (green) shows that tight junction-associated F-actin is not affected. Single confocal sections (with DAPI-stained nuclei in white). The magnified z-projected images ( bottom ) show a planar view onto the brush border. WT organoids show a continuous brush border ( asterisks ) that is interrupted in the Munc18-2 KO ( white arrowheads ). ( B ) Confocal analysis of F-actin (red) and Stx3 (green). Stx3 shows a diffuse subapical localization in the Munc18-2 KO ( white arrow ). Bottom : Magnified z-projected images. Scale bars : 10 mum. Staining was confirmed in 3 independent experiments.
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- Figure 1 Pericyte coverage is critical for formation and maturation of BRB. ( a ) Abundant PDGF-B mRNA expression in the tip ECs of vascular front (white arrowheads) at P5. PDGF-B mRNA was analysed by in situ hybridization (ISH), and then collagen type IV (ColIV) was detected by immunohistochemistry (IHC). ( b ) Immunostaining for PDGFRbeta + pericytes and CD31 + ECs in vascular front at P5. Note that there is no pericyte coverage in tip ECs (arrows). ( c ) Diagram for EC-specific depletion of PDGF-B in retinal vessels from P5 and their analyses at P12 using Pdgfb iDeltaEC mice. ( d - f ) Images of hemorrhage (red) and retinal detachment (dashed-line circle) in inner surface of retinal cup, and whitish inflammatory cell accumulations (white arrowheads) and irregular CD31 + vascular plexus in retinas of Pdgfb iDeltaEC mice are shown. ( g ) Images of NG2 + and PDGFRbeta + pericyte coverage onto CD31 + vessels, TER119 + RBC leakage (white arrowheads), F4/80 + macrophage infiltration, lectin perfusion, distributions of ZO-1 and VE-cadherin onto CD31 + ECs, and hypoxic area in retinas of WT and Pdgfb iDeltaEC mice are shown. HP, hypoxyprobe. ( h ) Comparisons of indicated parameters in WT (W; n =6) and Pdgfb iDeltaEC (P; n =6) mice. Error bars represent mean+-s.d. ** P
