18900-1-AP

antibody from Proteintech Group

Targeting: TJP2 DFNA51, X104, ZO-2, ZO2

Provider product page for 18900-1-AP

Western blot

ELISA

Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [36]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 18900-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#18900-1-AP, RRID:AB_2203584
Product name: ZO-2 antibody
Antibody type: Polyclonal
Description: ZO-2 antibody (Cat. #18900-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TJP2 protein structure - 18900-1-AP shown in red.

Submitted references Magnesium Deficiency Accelerates Gut Aging and Increases Susceptibility to Colitis.

Zhang R, Ge M, Hu M, Zhao Y, Chong B, Li W, Yu J, Lu Y, He S, Wang J, Yue J, Chen HN, Xu H, Peng Y, Lei P, Liu Z, Dai L
Aging cell 2026 Mar;25(3):e70446

Complement protein C1q induces endothelial apoptosis through C1qBP regulation of mitochondrial function in lung endothelial cells in systemic sclerosis.

Yi Z, Liu K, Shabin M
Molecular medicine (Cambridge, Mass.) 2026 Mar 5;32(1)

Uncovering the molecular mechanisms of tonifying kidney and activating blood Decoction against myocardial fibrosis using network Pharmacology and experimental validation.

Xu R, Bi Y, Ju Y, Yin W, Zhao S, Zhang Y, Zhao X
Scientific reports 2025 May 29;15(1):18912

The Minute Virus of Canines (MVC) Activates the RhoA/ROCK1/MLC2 Signal Transduction Pathway Resulting in the Dissociation of Tight Junctions and Facilitating Occludin-Mediated Viral Infection.

Ren X, Hei Z, Ji K, Yan Y, Tian C, Wei Y, Sun Y
Microorganisms 2025 Mar 20;13(3)

Fisetin alleviates Salmonella typhimurium-induced colitis through the TLR2/TLR4-NF-κB pathway, regulating microbiota, and repressing intracellular bacterial proliferation by focal adhesion kinase.

Li J, Yang Y, Zhang X, Yang Y, Wu Z
European journal of nutrition 2025 Mar 19;64(3):128

Taurine ameliorates deoxynivalenol-induced intestinal injury in piglets: Restoration of mitochondrial function linked to the PGC1α-NRF1/2 axis.

Ji X, Ding H, Zhou F, Zhang F, Wu D
Ecotoxicology and environmental safety 2025 Mar 1;292:117938

Endoscopic nasal delivery of engineered endothelial progenitor cell-derived exosomes improves angiogenesis and neurological deficits in rats with intracerebral hemorrhage.

Wan G, Li Z, Gu L, Sun Y, Wang Y, Wang Y, Geng R, Chen Y, Ma W, Bao X, Wang R
Materials today. Bio 2025 Jun;32:101652

RETRACTED ARTICLE: Copper Exposure Destroys the Integrity of the Blood-Testis Barrier (BTB) Through p38 MAPK-Meditated Autophagy Pathways.

Deng H, Lou Y, He R, Deng J, Zhu Y, Wu X, Guo H
Biological trace element research 2025 Jul;203(7):3987

Myosin Vb Traffics P-Glycoprotein to the Apical Membrane of Intestinal Epithelial Cells.

Dooley SA, Kolobova E, Burman A, Kaji I, Digrazia JR, Stubler R, Goldstein A, Packirisamy C, Coutts AW, Saqui-Salces M, Gao N, Engevik MA, Shub MD, Goldenring JR, Engevik AC
Gastroenterology 2025 Jan;168(1):84-98.e9

Blueberry extract for the treatment of ischaemic stroke through regulating the gut microbiota and kynurenine metabolism.

Wang R, Huang G, Li S, Huang H, Zhu G, Wang L, Yang J, Yang S, Jiang Z, Zhang W
Phytotherapy research : PTR 2024 Sep;38(9):4792-4814

Molecular alterations associated with pathophysiology in liver-specific ZO-1 and ZO-2 knockout mice.

Itoh M, Watanabe K, Mizukami Y, Sugimoto H
Cell structure and function 2024 Oct 26;49(2):83-99

An Isofibrous Diet with Fiber Konjac Glucomannan Ameliorates Salmonella typhimurium-Induced Colonic Injury by Regulating TLR2-NF-κB Signaling and Intestinal Microbiota in Mice.

Li J, Liu H, Fu H, Yang Y, Wu Z
Journal of agricultural and food chemistry 2024 Jun 12;72(23):13415-13430

Fructose induces hepatic steatosis in adolescent mice linked to the disorders of lipid metabolism, bile acid metabolism, and autophagy.

Deng S, Ge Y, Zhai Z, Liu H, Zhang X, Chen Y, Yang Y, Wu Z
The Journal of nutritional biochemistry 2024 Jul;129:109635

Bufei Yishen formula protects the airway epithelial barrier and ameliorates COPD by enhancing autophagy through the Sirt1/AMPK/Foxo3 signaling pathway.

Jia L, Liu X, Liu X, Guan Q, Tian Y, Li J, Zhao P
Chinese medicine 2024 Feb 28;19(1):32

Intestinal GSTpi deficiency exacerbates the severity of experimental hyperlipidemic acute pancreatitis.

Yang J, Wu B, Sha X, Lu H, Pan LL, Gu Y, Dong X
International immunopharmacology 2024 Aug 20;137:112363

Treatment with Ligilactobacillus murinus lowers blood pressure and intestinal permeability in spontaneously hypertensive rats.

Mukohda M, Yano T, Matsui T, Nakamura S, Miyamae J, Toyama K, Mitsui R, Mizuno R, Ozaki H
Scientific reports 2023 Sep 14;13(1):15197

3-Acetyldeoxynivalenol induces apoptosis, barrier dysfunction and endoplasmic reticulum stress by inhibiting mTORC1-dependent autophagy in porcine enterocytes.

Zhang T, Bai J, Chen G, Chen Z, Zeng S, Yang Y, Wu Z
Chemico-biological interactions 2023 Oct 1;384:110695

Gut Microbiota from Short-Chain Chlorinated Paraffin-Exposed Mice Promotes Astrocyte Activation by Disrupting the Intestinal Tight Junction via Zonulin Upregulation.

Zhao X, Zhang T, Zheng Y, Zhao Z, Ding W, Zhang Z, Zhang Z, Wang R, Jiao M, Liu L, Yu S, Wang X, Huang R, Wu Q
Journal of agricultural and food chemistry 2023 May 31;71(21):8192-8202

ZNF582 overexpression restrains the progression of clear cell renal cell carcinoma by enhancing the binding of TJP2 and ERK2 and inhibiting ERK2 phosphorylation.

Yang W, Zhang Z, Li L, Zhang K, Xu Y, Xia M, Zhou J, Gong Y, Chen J, Gong K
Cell death & disease 2023 Mar 25;14(3):212

Dietary pectin attenuates Salmonella typhimurium-induced colitis by modulating the TLR2-NF-κB pathway and intestinal microbiota in mice.

Li J, Bai J, Song Z, Ji Y, Chen Z, Yang Y, Wu Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114100

p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP.

Ouyang H, Wu S, Li W, Grey MJ, Wu W, Hansen SH
Cell reports 2023 Dec 26;42(12):113486

Beta-Amyloid Enhances Vessel Formation in Organotypic Brain Slices Connected to Microcontact Prints.

Steiner K, Humpel C
Biomolecules 2023 Dec 19;14(1)

Oral Delivery of Mouse β-Defensin 14 (mBD14)-Producing Lactococcus lactis NZ9000 Attenuates Experimental Colitis in Mice.

Tian H, Li J, Chen X, Ren Z, Pan X, Huang W, Bhatia M, Pan LL, Sun J
Journal of agricultural and food chemistry 2023 Apr 5;71(13):5185-5194

Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.

Li J, Bai J, Si X, Jia H, Wu Z
Chemico-biological interactions 2023 Apr 1;374:110386

Qingchang Wenzhong Decoction Prevents the Occurrence of Intestinal Tumors by Regulating Intestinal Microbiota and Gasdermin E.

Ren L, Zhang Z, Zhao W, Zhao B, Chen X, Wang Y, Chen Z, Ye J, Yang Y, Cao P
Frontiers in physiology 2022;13:917323

Morchella esculenta polysaccharide attenuate obesity, inflammation and modulate gut microbiota.

Rehman AU, Khan AI, Xin Y, Liang W
AMB Express 2022 Sep 3;12(1):114

Decreased ZO1 expression causes loss of time-dependent tight junction function in the liver of ob/ob mice.

Tsurudome Y, Morita N, Horiguchi M, Ushijima K
Molecular biology reports 2022 Dec;49(12):11881-11890

Calcium Binding Protein S100A16 Expedites Proliferation, Invasion and Epithelial-Mesenchymal Transition Process in Gastric Cancer.

You X, Li M, Cai H, Zhang W, Hong Y, Gao W, Liu Y, Liang X, Wu T, Chen F, Su D
Frontiers in cell and developmental biology 2021;9:736929

Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis.

Lei WL, Li YY, Meng TG, Ning Y, Sun SM, Zhang CH, Gui Y, Wang ZB, Qian WP, Sun QY
Cell death & disease 2021 Sep 27;12(10):883

Improved epithelial cell-cell adhesion using molecular mobility of supramolecular surfaces.

Mikami R, Arisaka Y, Hakariya M, Iwata T, Yui N
Biomaterials science 2021 Oct 26;9(21):7151-7158

The zonula occludens protein family regulates the hepatic barrier system in the murine liver.

Itoh M, Terada M, Sugimoto H
Biochimica et biophysica acta. Molecular basis of disease 2021 Jan 1;1867(1):165994

Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.

Tocmo R, Le B, Heun A, van Pijkeren JP, Parkin K, Johnson JJ
Free radical biology & medicine 2021 Feb 1;163:102-115

Responses of intestinal morphology and function in offspring to heat stress in primiparous sows during late gestation.

Guo H, He J, Yang X, Zheng W, Yao W
Journal of thermal biology 2020 Apr;89:102539

Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability.

Fu C, Hao S, Xu X, Zhou J, Liu Z, Lu H, Wang L, Jin W, Li S
Acta pharmacologica Sinica 2019 May;40(5):630-641

Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation.

Zhao M, Xiong X, Ren K, Xu B, Cheng M, Sahu C, Wu K, Nie Y, Huang Z, Blumberg RS, Han X, Ruan HB
EMBO molecular medicine 2018 Aug;10(8)

NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke.

Yang F, Wang Z, Wei X, Han H, Meng X, Zhang Y, Shi W, Li F, Xin T, Pang Q, Yi F
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014 Apr;34(4):660-7

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 18900-1-AP(TJP2 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of MCF-7 cells, using TJP2 antibody 18900-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line