10590-1-AP

antibody from Proteintech Group

Targeting: KRT6A CK6C, CK6D, K6C, K6D, KRT6C, KRT6D

Provider product page for 10590-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [20]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 10590-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10590-1-AP, RRID:AB_2134306
Product name: Cytokeratin 6A antibody
Antibody type: Polyclonal
Description: Cytokeratin 6A antibody (Cat. #10590-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

KRT6A protein structure - 10590-1-AP shown in red.

Submitted references Identification of Keratinocyte Cytoprotectants against Toxicity by the Multikinase Inhibitor Sorafenib Using Drug Repositioning.

Kamata Y, Kato R, Tominaga M, Toyama S, Komiya E, Utsumi J, Kaneko T, Suga Y, Takamori K
JID innovations : skin science from molecules to population health 2024 May;4(3):100271

GPCR Screening Reveals that the Metabolite Receptor HCAR3 Regulates Epithelial Proliferation, Migration, and Cellular Respiration.

Pedro MP, Lund K, Kang SWS, Chen T, Stuelten CH, Porat-Shliom N, Iglesias-Bartolome R
The Journal of investigative dermatology 2024 Jun;144(6):1311-1321.e7

ECM1 and KRT6A are involved in tumor progression and chemoresistance in the effect of dexamethasone on pancreatic cancer.

Shinomiya Y, Kouchi Y, Harada-Kagitani S, Ishige T, Takano S, Ohtsuka M, Ikeda JI, Kishimoto T
Cancer science 2024 Jun;115(6):1948-1963

Determination of the FABP5 expression profile in skin lesions of an IMQ-induced psoriasis mouse model using flow cytometry.

Yu J, Hao J, Yorek MS, Han X, Avellino A, Jiang X, Liu S, Wang J, Li B
STAR protocols 2024 Jun 21;5(2):103018

Keratin 6A Is Expressed at the Invasive Front and Enhances the Progression of Colorectal Cancer.

Harada-Kagitani S, Kouchi Y, Shinomiya Y, Kodama M, Ohira G, Matsubara H, Ikeda JI, Kishimoto T
Laboratory investigation; a journal of technical methods and pathology 2024 Jul;104(7):102075

Epigallocatechin-3-gallate promotes wound healing response in diabetic mice by activating keratinocytes and promoting re-epithelialization.

Ning Y, Yuan Z, Wang Q, He J, Zhu W, Ren DN, Wo D
Phytotherapy research : PTR 2024 Feb;38(2):1013-1027

In silico development and in vitro validation of a novel five-gene signature for prognostic prediction in colon cancer.

Zhu Q, Rao B, Chen Y, Jia P, Wang X, Zhang B, Wang L, Zhao W, Hu C, Tang M, Yu K, Chen W, Pan L, Xu Y, Luo H, Wang K, Li B, Shi H
American journal of cancer research 2023;13(1):45-65

Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer.

Yang X, Chen X, Zhang S, Fan W, Zhong C, Liu T, Cheng G, Zhu L, Liu Q, Xi Y, Tan W, Lin D, Wu C
Cell reports 2023 Oct 31;42(10):113270

Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis.

Hao J, Yu J, Yorek MS, Yu CL, Pope RM, Chimenti MS, Xiong Y, Klingelhutz A, Jabbari A, Li B
Cell reports 2023 Nov 28;42(11):113449

Characterization of genomic instability-related genes predicts survival and therapeutic response in lung adenocarcinoma.

Li S, Wang W, Yu H, Zhang S, Bi W, Sun S, Hong B, Fang Z, Chen X
BMC cancer 2023 Nov 16;23(1):1115

Sinapine thiocyanate exhibited anti-colorectal cancer effects by inhibiting KRT6A/S100A2 axis.

Yang Y, Zeng Z, Li L, Lei S, Wu Y, Chen T, Zhang J
Cancer biology & therapy 2023 Dec 31;24(1):2249170

Differentially expressed proteins identified by TMT proteomics analysis in children with verrucous epidermal naevi.

Yuan T, Cai ML, Sheng YM, Ding X, Shen TT, Li WR, Huang H, Liang B, Zhang XJ, Zhu QX
Journal of the European Academy of Dermatology and Venereology : JEADV 2021 Jun;35(6):1393-1406

PDGF-BB/SA/Dex injectable hydrogels accelerate BMSC-mediated functional full thickness skin wound repair by promoting angiogenesis.

Zhang Z, Li Z, Wang Y, Wang Q, Yao M, Zhao L, Shi J, Guan F, Ma S
Journal of materials chemistry. B 2021 Aug 21;9(31):6176-6189

Anti-tumour effects of Keratin 6A in lung adenocarcinoma.

Xiao J, Kuang X, Dai L, Zhang L, He B
The clinical respiratory journal 2020 Jul;14(7):667-674

Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.

Lou F, Sun Y, Xu Z, Niu L, Wang Z, Deng S, Liu Z, Zhou H, Bai J, Yin Q, Cai X, Sun L, Wang H, Li Q, Wu Z, Chen X, Gu J, Shi YL, Tao W, Ginhoux F, Wang H
Immunity 2020 Jul 14;53(1):204-216.e10

Ozone therapy promotes the differentiation of basal keratinocytes via increasing Tp63-mediated transcription of KRT10 to improve psoriasis.

Gao L, Dou J, Zhang B, Zeng J, Cheng Q, Lei L, Tan L, Zeng Q, Ding S, Guo A, Cheng H, Yang C, Luo Z, Lu J
Journal of cellular and molecular medicine 2020 Apr;24(8):4819-4829

miR124-3p/FGFR2 axis inhibits human keratinocyte proliferation and migration and improve the inflammatory microenvironment in psoriasis.

Xiao Y, Wang C, Zeng B, Tang X, Zhang Y, Xiang L, Mi L, Pan Y, Wang H, Yang Z
Molecular immunology 2020 Apr 21;122:89-98

Combination of paromomycin plus human anti-TNF-α antibodies to control the local inflammatory response in BALB/ mice with cutaneous leishmaniasis lesions.

Schwartz J, Moreno E, Calvo A, Blanco L, Fernández-Rubio C, Sanmartín C, Nguewa P, Irache JM, Larrea E, Espuelas S
Journal of dermatological science 2018 Oct;92(1):78-88

Effect of glycosides of Cistanche on the expression of mitochondrial precursor protein and keratin type II cytoskeletal 6A in a rat model of vascular dementia.

Zhang YM, Wu W, Ma W, Wang F, Yuan J
Neural regeneration research 2017 Jul;12(7):1152-1158

Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.

Sun B, Bai Y, Zhang L, Gong L, Qi X, Li H, Wang F, Chi X, Jiang Y, Shao S
PloS one 2016;11(9):e0163622

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: A431 cells were subjected to SDS PAGE followed by western blot with 10590-1-AP(KRT6A antibody) at dilution of 1:2000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using KRT6A antibody 10590-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human prostate cancer using 10590-1-AP(KRT6A antibody) at dilution of 1:100 (under 25x lens)
Sample type: tissue