DMAB5414MH

antibody from Creative Diagnostics

Targeting: KRT6A CK6C, CK6D, K6C, K6D, KRT6C, KRT6D

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DMAB5414MH

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DMAB5414MH, RRID:AB_2395311

Product name

Anti-Cytokeratin 6 monoclonal antibody, clone MIL7C

Antibody type

Monoclonal

Description

Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation related keratins). Keratin 6 is found in hair follicles, neck squamous cell carcinomas, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation. There are at least six isoforms of human type II keratin 6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

MIL7C

Storage

Store at 2-8°C. Do not use beyond the expiration date stated on the label.