orb386042

antibody from Biorbyt

Targeting: KRT6A CK6C, CK6D, K6C, K6D, KRT6C, KRT6D

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb386042

Provider

Biorbyt

Product name

Keratin 6 Antibody / Cytokeratin 6

Antibody type

Monoclonal

Description

This mAb recognizes a protein of 56kDa, identified as Cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.

Reactivity

Human, Mouse

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

KRT6/1702

Vial size

20 ug

Storage

Store the Cytokeratin 6 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).