Antibody data
- Antibody Data
- Antigen structure
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- Product number
- orb152274 - Provider product page
- Provider
- Biorbyt
- Product name
- SOD1 (EDI) antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal to SOD1 (HRP). Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body. It works by catalyzing the dismutation of the superoxide radical O2 to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (1,4). In general, SODs play a major role in antioxidant defense mechanisms. There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge. Misfolding of SOD1 has been implicated in Amyotrophic lateral sclerosis (ALS). Therefore conformation specific antibodies such as SOD1 (EDI), which targets an exposed region of the dimer interface (EDI) of SOD1, are useful for determining the conformation of SOD1 in affected tissues. This antibody can be used in conjunction with SOD1 (U beta B) (SPC-205D) which detects an unfolded beta barrel (U beta B) of SOD1..
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Rabbit
- Conjugate
- Horseradish Peroxidase
- Vial size
- 100 μg
- Concentration
- 1 mg/ml
- Storage
- Conjugated antibodies should be stored at 4°C
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