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Western blot
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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [25]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- HPA001401 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA001401, RRID:AB_1080132
- Product name
- Anti-SOD1
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human SOD1, Gene description: superoxide dismutase 1, soluble, Alternative Gene Names: ALS, ALS1, IPOA, Validated applications: WB, IHC, ICC, Uniprot ID: P00441, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.1 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references A cellular taxonomy of the adult human spinal cord
Probing Oxidant Effects on Superoxide Dismutase 1 Oligomeric States in Live Cells Using Single-Molecule Fluorescence Anisotropy
Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain.
DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster
Sustained IKKβ phosphorylation and NF-κB activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56γ3 and PP2A inactivation
Direct and Indirect Antioxidant Effects of Selected Plant Phenolics in Cell-Based Assays
Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells
Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients
Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System
CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance
GSE4 peptide suppresses oxidative and telomere deficiencies in ataxia telangiectasia patient cells
A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection
Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALS
Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis
Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity
Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK 4/6 inhibitor palbociclib
DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1
Caffeine intake decreases oxidative stress and inflammatory biomarkers in experimental liver diseases induced by thioacetamide: Biochemical and histological study
Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms
myo-Inositol Oxygenase Overexpression Accentuates Generation of Reactive Oxygen Species and Exacerbates Cellular Injury following High Glucose Ambience
Acute intermittent hypoxia induced phrenic long-term facilitation despite increased SOD1 expression in a rat model of ALS
Marinesco-Sjögren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS
NQO2 Is a Reactive Oxygen Species Generating Off-Target for Acetaminophen
Yadav A, Matson K, Li L, Hua I, Petrescu J, Kang K, Alkaslasi M, Lee D, Hasan S, Galuta A, Dedek A, Ameri S, Parnell J, Alshardan M, Qumqumji F, Alhamad S, Wang A, Poulen G, Lonjon N, Vachiery-Lahaye F, Gaur P, Nalls M, Qi Y, Maric D, Ward M, Hildebrand M, Mery P, Bourinet E, Bauchet L, Tsai E, Phatnani H, Le Pichon C, Menon V, Levine A
Neuron 2023;111(3):328-344.e7
Neuron 2023;111(3):328-344.e7
Probing Oxidant Effects on Superoxide Dismutase 1 Oligomeric States in Live Cells Using Single-Molecule Fluorescence Anisotropy
Chen H, Chen T
Chemical & Biomedical Imaging 2023;1(1):49-57
Chemical & Biomedical Imaging 2023;1(1):49-57
Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain.
Luo Y, Chatre L, Melhem S, Al-Dahmani ZM, Homer NZM, Miedema A, Deelman LE, Groves MR, Feelisch M, Morton NM, Dolga A, van Goor H
Redox biology 2023 Dec;68:102965
Redox biology 2023 Dec;68:102965
DJ-1 and SOD1 Act Independently in the Protection against Anoxia in Drosophila melanogaster
De Lazzari F, Agostini F, Doni D, Malacrida S, Zordan M, Costantini P, Bubacco L, Sandrelli F, Bisaglia M
Antioxidants 2022;11(8):1527
Antioxidants 2022;11(8):1527
Sustained IKKβ phosphorylation and NF-κB activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56γ3 and PP2A inactivation
Yee Y, Chong S, Kong L, Goh B, Pervaiz S
Redox Biology 2021;41
Redox Biology 2021;41
Direct and Indirect Antioxidant Effects of Selected Plant Phenolics in Cell-Based Assays
Treml J, Večeřová P, Herczogová P, Šmejkal K
Molecules 2021;26(9):2534
Molecules 2021;26(9):2534
Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells
Ceder S, Eriksson S, Liang Y, Cheteh E, Zhang S, Fujihara K, Bianchi J, Bykov V, Abrahmsen L, Clemons N, Nordlund P, Rudd S, Wiman K
Cell Death & Disease 2021;12(7)
Cell Death & Disease 2021;12(7)
Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients
Bayer D, Antonucci S, Müller H, Saad R, Dupuis L, Rasche V, Böckers T, Ludolph A, Kassubek J, Roselli F
Translational Neurodegeneration 2021;10(1)
Translational Neurodegeneration 2021;10(1)
CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia
Lind A, Just D, Mikus M, Fredolini C, Ioannou M, Gerdle B, Ghafouri B, Bäckryd E, Tanum L, Gordh T, Månberg A
Journal of Pain Research 2019;Volume 12
Journal of Pain Research 2019;Volume 12
Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System
Treml J, Leláková V, Šmejkal K, Paulíčková T, Labuda Š, Granica S, Havlík J, Jankovská D, Padrtová T, Hošek J
Biomolecules 2019;9(9):468
Biomolecules 2019;9(9):468
CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance
Langebäck A, Bacanu S, Laursen H, Mout L, Seki T, Erkens-Schulze S, Ramos A, Berggren A, Cao Y, Hartman J, van Weerden W, Bergh J, Nordlund P, Lööf S
Scientific Reports 2019;9(1)
Scientific Reports 2019;9(1)
GSE4 peptide suppresses oxidative and telomere deficiencies in ataxia telangiectasia patient cells
Pintado-Berninches L, Fernandez-Varas B, Benitez-Buelga C, Manguan-Garcia C, Serrano-Benitez A, Iarriccio L, Carrillo J, Guenechea G, Egusquiaguirre S, Pedraz J, Hernández R, Igartua M, Arias-Salgado E, Cortés-Ledesma F, Sastre L, Perona R
Cell Death & Differentiation 2019;26(10):1998-2014
Cell Death & Differentiation 2019;26(10):1998-2014
A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection
Månberg A, Bradley F, Qundos U, Guthrie B, Birse K, Noël-Romas L, Lindskog C, Bosire R, Kiarie J, Farquhar C, Burgener A, Nilsson P, Broliden K
Molecular & Cellular Proteomics 2019;18(3):461-476
Molecular & Cellular Proteomics 2019;18(3):461-476
Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALS
Ryu H, Rando A, de la Torre M, Martinez-Muriana A, Zaragoza P, Musaro A, Hernández S, Navarro X, Toivonen J, Osta R
PLOS ONE 2019;14(1):e0210752
PLOS ONE 2019;14(1):e0210752
Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis
Maruyama T, Baba T, Maemoto Y, Hara-Miyauchi C, Hasegawa-Ogawa M, Okano H, Enda Y, Matsumoto K, Arimitsu N, Nakao K, Hamamoto H, Sekimizu K, Ohto-Nakanishi T, Nakanishi H, Tokuyama T, Yanagi S, Tagaya M, Tani K
Cell Death & Disease 2018;9(8)
Cell Death & Disease 2018;9(8)
Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity
Yang S, Martinez N, Yasgar A, Danchik C, Johansson C, Wang Y, Baljinnyam B, Wang A, Xu X, Shah P, Cheff D, Wang X, Roth J, Lal-Nag M, Dunford J, Oppermann U, Vasiliou V, Simeonov A, Jadhav A, Maloney D
Journal of Medicinal Chemistry 2018;61(11):4883-4903
Journal of Medicinal Chemistry 2018;61(11):4883-4903
Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK 4/6 inhibitor palbociclib
Miettinen T, Peltier J, Härtlova A, Gierliński M, Jansen V, Trost M, Björklund M
The EMBO Journal 2018;37(10)
The EMBO Journal 2018;37(10)
DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade
Touat M, Sourisseau T, Dorvault N, Chabanon R, Garrido M, Morel D, Krastev D, Bigot L, Adam J, Frankum J, Durand S, Pontoizeau C, Souquère S, Kuo M, Sauvaigo S, Mardakheh F, Sarasin A, Olaussen K, Friboulet L, Bouillaud F, Pierron G, Ashworth A, Lombès A, Lord C, Soria J, Postel-Vinay S
Journal of Clinical Investigation 2018;128(4):1671-1687
Journal of Clinical Investigation 2018;128(4):1671-1687
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1
Tripathi P, Rodriguez-Muela N, Klim J, de Boer A, Agrawal S, Sandoe J, Lopes C, Ogliari K, Williams L, Shear M, Rubin L, Eggan K, Zhou Q
Stem Cell Reports 2017;9(2):667-680
Stem Cell Reports 2017;9(2):667-680
Caffeine intake decreases oxidative stress and inflammatory biomarkers in experimental liver diseases induced by thioacetamide: Biochemical and histological study
Amer M, Mazen N, Mohamed A
International Journal of Immunopathology and Pharmacology 2017;30(1):13-24
International Journal of Immunopathology and Pharmacology 2017;30(1):13-24
Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms
Madill M, McDonagh K, Ma J, Vajda A, McLoughlin P, O’Brien T, Hardiman O, Shen S
Molecular Brain 2017;10(1)
Molecular Brain 2017;10(1)
myo-Inositol Oxygenase Overexpression Accentuates Generation of Reactive Oxygen Species and Exacerbates Cellular Injury following High Glucose Ambience
Sun L, Dutta R, Xie P, Kanwar Y
Journal of Biological Chemistry 2016;291(11):5688-5707
Journal of Biological Chemistry 2016;291(11):5688-5707
Acute intermittent hypoxia induced phrenic long-term facilitation despite increased SOD1 expression in a rat model of ALS
Nichols N, Satriotomo I, Harrigan D, Mitchell G
Experimental Neurology 2015;273
Experimental Neurology 2015;273
Marinesco-Sjögren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS
Filézac de L'Etang A, Maharjan N, Cordeiro Braña M, Ruegsegger C, Rehmann R, Goswami A, Roos A, Troost D, Schneider B, Weis J, Saxena S
Nature Neuroscience 2015;18(2):227-238
Nature Neuroscience 2015;18(2):227-238
NQO2 Is a Reactive Oxygen Species Generating Off-Target for Acetaminophen
Miettinen T, Björklund M
Molecular Pharmaceutics 2014;11(12):4395-4404
Molecular Pharmaceutics 2014;11(12):4395-4404
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Enhanced validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Western blot analysis in Hep-G2 cells transfected with control siRNA, target specific siRNA probe #1, using Anti-SOD1 antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.
- Sample type
- Human
- Protocol
- Protocol
Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human liver and pancreas tissues using HPA001401 antibody. Corresponding SOD1 RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
