28100-1-AP

antibody from Proteintech Group

Targeting: KL

Provider product page for 28100-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [32]
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Product number: 28100-1-AP - Provider product page
Provider: Proteintech Group
Product name: KL antibody
Antibody type: Polyclonal
Description: KL antibody (Cat. #28100-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human, Mouse and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

KL protein structure - 28100-1-AP shown in red.

Submitted references Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X-Linked Hypophosphatemic Rickets.

Wu H, Zhao W, Chen X, Wang Y, Wei S, Xiang B, Shi Y, Li Z, Yao Y, Xie J, Qiu R, Shu M, Xu S, Chen P, Chen Z, Wu Y, Xia W, Gao L, Song Y, Zhao J, Xu C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(4):e08870

Klotho protects the osteogenic function of human periodontal ligament stem cells in periodontitis by inhibiting NOX4-mediated ferroptosis.

Lin C, Wei J, Zhao T, Chen L, Rong S, Zhan J, Lai W, Wang Y, Xie Y, Chen H
Stem cell research & therapy 2026 Jan 16;17(1):81

FOXP1 deficiency exacerbates cellular senescence in PM(2.5)-induced renal injury.

Chen H, Zhan Z, Lu M, Li D, Peng J, Chen L, Yi B, Huang Z
Ecotoxicology and environmental safety 2026 Apr 1;314:120071

Expression and clinical significance of Klotho protein in serum, umbilical cord blood, and placenta of pregnant women with intrauterine growth restriction.

Zeng G, Lian J, Shen J, Shi Y
Frontiers in pediatrics 2025;13:1611877

Suyin Detoxification Prescription Regulates the Klotho and ERK/NF-κB Signaling Pathways to Alleviate Renal Injury.

Shu L, Quan L, Wang Y, Chen Y, Yong C, Tian F, Gao K, Zhou E
Cell biochemistry and biophysics 2025 Sep;83(3):3137-3152

Irisin attenuates liver fibrosis by regulating energy metabolism and HMGB1/β-catenin signaling in hepatic stellate cells.

Li F, Liu X, Bai N, Li Y, Hou M, Hou Y, Liu Y, Wang X, He Q, Li J
European journal of pharmacology 2025 Jul 5;998:177519

Hesperidin Reverses Oxidative Stress-Induced Damage in Kidney Cells by Modulating Antioxidant, Longevity, and Senescence-Related Genes.

Buakaew S, Sakonsinsiri C, Lert-Itthiporn W, Cha'on U, Rudtanatip T, Kraiklang R, Kaewlert W, Rattanaseth P, Pakdeechote P, Thanan R
Biomedicines 2025 Dec 9;13(12)

Klotho improves Der p1-induced bronchial epithelial cell damage by inhibiting endoplasmic reticulum stress to regulate mitochondrial function.

Wang C, Liu Z, Xie X, Li Y, Sun L
Tissue & cell 2025 Apr;93:102646

Astragaloside I from Astragalus Attenuates Diabetic Kidney Disease by Regulating HDAC3/Klotho/TGF-β1 Loop.

Zhang X, Wang J, Xiang S, Zhao L, Lv M, Duan Y, Gao G, Wang P, Jie Chen J, Xu J, Xie Z, Zhang Z
The American journal of Chinese medicine 2024;52(6):1795-1817

Polystyrene microplastics facilitate renal fibrosis through accelerating tubular epithelial cell senescence.

Pan C, Wang X, Fan Z, Mao W, Shi Y, Wu Y, Liu T, Xu Z, Wang H, Chen H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Sep;191:114888

Aging alters the expression of trophic factors and tight junction proteins in the mouse choroid plexus.

Sadanandan J, Sathyanesan M, Newton SS
Fluids and barriers of the CNS 2024 Sep 27;21(1):77

Vitamin D inhibits ferroptosis and mitigates the kidney injury of prediabetic mice by activating the Klotho/p53 signaling pathway.

Chen H, Zhang Y, Miao Y, Song H, Tang L, Liu W, Li W, Miao J, Li X
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1780-1792

ABI3BP promotes renal aging through Klotho-mediated ferroptosis.

Ji R, Wei L, Zan Y, Li X, Ma S, Ma L, He X, Wang L, Ding Y
Journal of translational medicine 2024 May 29;22(1):514

Regulation of trophic factors in the choroid plexus of aged mice.

Sadanandan J, Sathyanesan M, Newton SS
Research square 2024 Mar 22;

Effects of selenium-cadmium co-enriched Cardamine hupingshanensis on bone damage in mice.

Zhang L, Shi WY, Zhang LL, Sha Y, Xu JY, Shen LC, Li YH, Yuan LX, Qin LQ
Ecotoxicology and environmental safety 2024 Mar 1;272:116101

Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4.

Wang X, Chang HC, Gu X, Han W, Mao S, Lu L, Jiang S, Ding H, Han S, Qu X, Bao Z
Mechanisms of ageing and development 2024 Jun;219:111932

Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism.

Liu J, Wang H, Liu Q, Long S, Wu Y, Wang N, Lin W, Chen G, Lin M, Wen J
Cell & bioscience 2024 Apr 7;14(1):46

Paricalcitol improved cardiac hypertrophy and fibrosis through upregulation of fibroblast growth factor-23 and downregulation of transforming growth factor-beta in a rat model of isoproterenol-induced cardiomyopathy.

Wu CJ, Li YH, Chen HH
The Chinese journal of physiology 2023 Sep-Oct;66(5):306-312

Lee CT, Ng HY, Zhong HR, Wang Y, Liu CH, Lee YT
International journal of molecular sciences 2023 Nov 17;24(22)

Klotho protects against aged myocardial cells by attenuating ferroptosis.

Xiong X, Wang G, Wang Y, Zhang T, Bao Y, Wang K, Ainiwaer D, Sun Z
Experimental gerontology 2023 May;175:112157

Hypoxia-Induced Kidney Injury in Newborn Rats.

Chu YT, Chen BH, Chen HH, Lee JC, Kuo TJ, Chiu HC, Lu WH
Toxics 2023 Mar 11;11(3)

Peripheral Klotho protects the kidney and brain by regulating M2a/M2c macrophage polarization in d-gal-treated aged mice.

Wang Y, Xiong X, Wang K, Bao Y, Zhang T, Ainiwaer D, Wang G, Li H, Sun Z
Tissue & cell 2023 Jun;82:102049

Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease.

Li C, Liu Q, Chang Q, Xie M, Weng J, Wang X, Li M, Chen J, Huang Y, Yang X, Wang K, Zhang N, Chung KF, Adcock IM, Zhang H, Li F
Respiratory research 2023 Dec 18;24(1):319

Cigarette Smoke Exposure Increases Glucose-6-phosphate Dehydrogenase, Autophagy, Fibrosis, and Senescence in Kidney Cells In Vitro and In Vivo.

Liu WC, Chuang HC, Chou CL, Lee YH, Chiu YJ, Wang YL, Chiu HW
Oxidative medicine and cellular longevity 2022;2022:5696686

Upregulation of Klotho Aggravates Insulin Resistance in Gestational Diabetes Mellitus Trophoblast Cells.

Lin L, Wang X, Zhao W, Chen Y
Genetics research 2022;2022:1500768

Upregulation of hypothalamic POMC neurons after biliary diversion in GK rats.

Zhou S, Chen W, Bai X, Chen J, Xu Q, Dong L, Chen W, Qu Q, He X
Frontiers in endocrinology 2022;13:999928

Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho.

Zhou W, Chen MM, Liu HL, Si ZL, Wu WH, Jiang H, Wang LX, Vaziri ND, An XF, Su K, Chen C, Tan NH, Zhang ZH
Acta pharmacologica Sinica 2022 Oct;43(10):2609-2623

Low-Dose Propranolol Prevents Functional Decline in Catecholamine-Induced Acute Heart Failure in Rats.

Tsai CK, Chen BH, Chen HH, Hsieh RJ, Lee JC, Chu YT, Lu WH
Toxics 2022 May 7;10(5)

Serine protease HtrA2/Omi regulates adaptive mitochondrial reprogramming in the brain cortex after ischemia/reperfusion injury via UCP2-SIRT3-PGC1 axis.

Meng H, Sun LK, Su J, Yan WY, Jin Y, Luo X, Jiang XR, Wang HL
Human cell 2022 Jan;35(1):63-82

PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats.

Li J, Peng C, Lai D, Fang Y, Luo D, Zhou Z, Li C, Lai X
Scientific reports 2021 May 26;11(1):10973

α-Klotho released from HK-2 cells inhibits osteogenic differentiation of renal interstitial fibroblasts by inactivating the Wnt-β-catenin pathway.

Zhu Z, Ruan S, Jiang Y, Huang F, Xia W, Chen J, Cui Y, He C, Zeng F, Li Y, Chen Z, Chen H
Cellular and molecular life sciences : CMLS 2021 Dec;78(23):7831-7849

The protective mechanism of Klotho gene-modified bone marrow mesenchymal stem cells on acute kidney injury induced by rhabdomyolysis.

Ni W, Zhang Y, Yin Z
Regenerative therapy 2021 Dec;18:255-267

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