Antibody data
- Antibody Data
- Antigen structure
- References [36]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
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- Product number
- 18257-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18257-1-AP, RRID:AB_10598162
- Product name
- GSR antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GSR antibody (Cat. #18257-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Solasonine inhibits NSCLC malignant progression by regulating SLC7A11 ubiquitination degradation and inducing ferroptosis.
Contribution of ferroptosis and SLC7A11 to light-induced photoreceptor degeneration.
Baicalein suppresses the malignant progression of acute myeloid leukemia via ROS-dependent metabolic reprogramming: Mechanisms of differentiation induction and ferroptosis activation.
IL-6/KIAA1429 promotes ferroptosis resistance in endometrial cancer through m6A modification of DDIT3.
GSR Deficiency Exacerbates Oxidative Stress and Promotes Pulmonary Fibrosis.
Elemene mitigates oxidative stress and neuronal apoptosis induced by cerebral ischemia-reperfusion injury through the regulation of glutathione metabolism.
The human zinc-binding cysteine proteome.
Fraxin inhibits ovariectomized-induced bone loss and osteoclastogenesis by suppressing ROS activity.
Glutathione reductase underlies the stability of mutant p53 by antagonizing protein glutathionylation.
Pharmacological Inhibition of TXNRD1 by a Small Molecule Flavonoid Butein Overcomes Cisplatin Resistance in Lung Cancer Cells.
MDSCs promote pathological angiogenesis in ocular neovascular disease.
MMP9 drives ferroptosis by regulating GPX4 and iron signaling.
Therapeutic potential of omaveloxolone in counteracting muscle atrophy post-denervation: a multi-omics approach.
In-depth analysis of lymph node metastasis-related sialylated protein profiling and their clinical and biological significance in colorectal cancer using mass spectrometry and multi-omics technologies.
Proline metabolic reprogramming modulates cardiac remodeling induced by pressure overload in the heart.
Physiological and molecular predictors of cycling sprint performance.
MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells.
A family of NADPH/NADP(+) biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes.
Exacerbated response to oxidative stress in the Retinitis Pigmentosa Cerkl(KD/KO) mouse model triggers retinal degeneration pathways upon acute light stress.
Antioxidant enzymes and Nrf2/Keap1 in human skeletal muscle: Influence of age, sex, adiposity and aerobic fitness.
Extracellular arginine availability modulates eIF2α O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.
A Mango Leaf Extract (Zynamite(®)) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle.
A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.
GSK 650394 Inhibits Osteoclasts Differentiation and Prevents Bone Loss via Promoting the Activities of Antioxidant Enzymes In Vitro and In Vivo.
Fast regulation of the NF-κB signalling pathway in human skeletal muscle revealed by high-intensity exercise and ischaemia at exhaustion: Role of oxygenation and metabolite accumulation.
Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity.
Anti-Inflammatory Effect of Dimethyl Fumarate Associates with the Inhibition of Thioredoxin Reductase 1 in RAW 264.7 Cells.
Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming.
Desflurane Preconditioning Protects Against Renal Ischemia-Reperfusion Injury and Inhibits Inflammation and Oxidative Stress in Rats Through Regulating the Nrf2-Keap1-ARE Signaling Pathway.
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death.
GSH-dependent antioxidant defense contributes to the acclimation of colon cancer cells to acidic microenvironment.
The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.
Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes.
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Wang Y, Li X, Zhou C, Qian M, Zou Z, Yang W, Wilfred NSJ, Huang G, Xu X, Xue F, Jin M
Respiratory research 2026 Jan 28;27(1):90
Respiratory research 2026 Jan 28;27(1):90
Contribution of ferroptosis and SLC7A11 to light-induced photoreceptor degeneration.
Huang X, Zhang Y, Jiang Y, Li T, Yang S, Wang Y, Yu B, Zhou M, Zhang G, Zhao X, Sun J, Sun X
Neural regeneration research 2026 Jan 1;21(1):406-416
Neural regeneration research 2026 Jan 1;21(1):406-416
Baicalein suppresses the malignant progression of acute myeloid leukemia via ROS-dependent metabolic reprogramming: Mechanisms of differentiation induction and ferroptosis activation.
Wang M, Wang Y, Chen L, Yu S, Li X, Huang G, Jin M
European journal of pharmacology 2025 Sep 5;1002:177839
European journal of pharmacology 2025 Sep 5;1002:177839
IL-6/KIAA1429 promotes ferroptosis resistance in endometrial cancer through m6A modification of DDIT3.
Shen X, Shu W, Zhang J, Zhou T, Dong K, Zhang J, Yao Y, Li H, Cheng S, Zhang T, Chen G, Yu S, Zhang Q, Wang H, Liu Y
Cellular signalling 2025 Oct;134:111906
Cellular signalling 2025 Oct;134:111906
GSR Deficiency Exacerbates Oxidative Stress and Promotes Pulmonary Fibrosis.
Zhao W, Cao H, Xu W, Duan Y, Gan Y, Huang S, Cao Y, Long S, Zhang Y, Yu G, Wang L
Biomolecules 2025 Jul 20;15(7)
Biomolecules 2025 Jul 20;15(7)
Elemene mitigates oxidative stress and neuronal apoptosis induced by cerebral ischemia-reperfusion injury through the regulation of glutathione metabolism.
Wu P, Cheng LH, Liu YL, Zhang JL, Dong XM, Chen L, Xu YX, Ren YY, Zhang HM, Liu ZQ, Zhou JL, Xie T
Journal of ethnopharmacology 2025 Jan 31;340:119166
Journal of ethnopharmacology 2025 Jan 31;340:119166
The human zinc-binding cysteine proteome.
Burger N, Mittenbühler MJ, Xiao H, Shin S, Wei SM, Henze EK, Schindler S, Mehravar S, Wood DM, Petrocelli JJ, Sun Y, Sprenger HG, Latorre-Muro P, Smythers AL, Bozi LHM, Darabedian N, Zhu Y, Seo HS, Dhe-Paganon S, Che J, Chouchani ET
Cell 2025 Feb 6;188(3):832-850.e27
Cell 2025 Feb 6;188(3):832-850.e27
Fraxin inhibits ovariectomized-induced bone loss and osteoclastogenesis by suppressing ROS activity.
Zhou H, Chen P, Zhao C, Zou S, Wu H, Huang C, Hu H, Wu Q, Zhang C, Weng W
International immunopharmacology 2025 Feb 6;147:113871
International immunopharmacology 2025 Feb 6;147:113871
Glutathione reductase underlies the stability of mutant p53 by antagonizing protein glutathionylation.
Wang L, Zhong S, Fan X, Xu Y, Wang M, Xu Y, Cai Y, Cao Z, Ye Z, Wen L, Wei P
Redox biology 2025 Apr;81:103522
Redox biology 2025 Apr;81:103522
Pharmacological Inhibition of TXNRD1 by a Small Molecule Flavonoid Butein Overcomes Cisplatin Resistance in Lung Cancer Cells.
Yang R, Sun S, Zhang Q, Liu H, Wang L, Meng Y, Chen N, Wang Z, Liu H, Ji F, Dai Y, He G, Xu W, Ye Z, Zhang J, Ma Q, Xu J
Biological trace element research 2025 Apr;203(4):1949-1960
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MDSCs promote pathological angiogenesis in ocular neovascular disease.
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MMP9 drives ferroptosis by regulating GPX4 and iron signaling.
Gawargi FI, Mishra PK
iScience 2024 Sep 20;27(9):110622
iScience 2024 Sep 20;27(9):110622
Therapeutic potential of omaveloxolone in counteracting muscle atrophy post-denervation: a multi-omics approach.
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Journal of translational medicine 2024 Nov 2;22(1):991
Journal of translational medicine 2024 Nov 2;22(1):991
In-depth analysis of lymph node metastasis-related sialylated protein profiling and their clinical and biological significance in colorectal cancer using mass spectrometry and multi-omics technologies.
Shao Y, Yu M, Zhang L, Zhou L, Yan X, Feng B, Zhang S
Scientific reports 2024 Nov 18;14(1):28535
Scientific reports 2024 Nov 18;14(1):28535
Proline metabolic reprogramming modulates cardiac remodeling induced by pressure overload in the heart.
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Science advances 2024 May 10;10(19):eadl3549
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Physiological and molecular predictors of cycling sprint performance.
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Scandinavian journal of medicine & science in sports 2024 Jan;34(1):e14545
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MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells.
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Cell death discovery 2024 Jan 5;10(1):9
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A family of NADPH/NADP(+) biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes.
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Nature communications 2024 Dec 19;15(1):10704
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Exacerbated response to oxidative stress in the Retinitis Pigmentosa Cerkl(KD/KO) mouse model triggers retinal degeneration pathways upon acute light stress.
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Redox biology 2023 Oct;66:102862
Redox biology 2023 Oct;66:102862
Antioxidant enzymes and Nrf2/Keap1 in human skeletal muscle: Influence of age, sex, adiposity and aerobic fitness.
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Free radical biology & medicine 2023 Nov 20;209(Pt 2):282-291
Extracellular arginine availability modulates eIF2α O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.
Hung YW, Ouyang C, Ping X, Qi Y, Wang YC, Kung HJ, Ann DK
Journal of biomedical science 2023 May 22;30(1):32
Journal of biomedical science 2023 May 22;30(1):32
A Mango Leaf Extract (Zynamite(®)) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle.
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Nutrients 2023 Jun 23;15(13)
Nutrients 2023 Jun 23;15(13)
A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.
Wang Y, Tang B, Li H, Zheng J, Zhang C, Yang Z, Tan X, Luo P, Ma L, Wang Y, Long L, Chen Z, Xiao Z, Ma L, Zhou J, Wang Y, Shi C
EBioMedicine 2023 Apr;90:104480
EBioMedicine 2023 Apr;90:104480
GSK 650394 Inhibits Osteoclasts Differentiation and Prevents Bone Loss via Promoting the Activities of Antioxidant Enzymes In Vitro and In Vivo.
Jin LY, Huo SC, Guo C, Liu HY, Xu S, Li XF
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Oxidative medicine and cellular longevity 2022;2022:3458560
Fast regulation of the NF-κB signalling pathway in human skeletal muscle revealed by high-intensity exercise and ischaemia at exhaustion: Role of oxygenation and metabolite accumulation.
Gallego-Selles A, Galvan-Alvarez V, Martinez-Canton M, Garcia-Gonzalez E, Morales-Alamo D, Santana A, Gonzalez-Henriquez JJ, Dorado C, Calbet JAL, Martin-Rincon M
Redox biology 2022 Sep;55:102398
Redox biology 2022 Sep;55:102398
Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity.
Jin X, Li X, Li L, Zhong B, Hong Y, Niu J, Li B
The Journal of biological chemistry 2022 Dec;298(12):102587
The Journal of biological chemistry 2022 Dec;298(12):102587
Anti-Inflammatory Effect of Dimethyl Fumarate Associates with the Inhibition of Thioredoxin Reductase 1 in RAW 264.7 Cells.
Yang R, Sun S, Guo Y, Meng Y, Liu H, Shi M, Guan S, Xu J
Molecules (Basel, Switzerland) 2022 Dec 23;28(1)
Molecules (Basel, Switzerland) 2022 Dec 23;28(1)
Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming.
Chang MT, Tsai LC, Nakagawa-Goto K, Lee KH, Shyur LF
Pharmacological research 2022 Apr;178:106148
Pharmacological research 2022 Apr;178:106148
Desflurane Preconditioning Protects Against Renal Ischemia-Reperfusion Injury and Inhibits Inflammation and Oxidative Stress in Rats Through Regulating the Nrf2-Keap1-ARE Signaling Pathway.
Zheng Y, Lu H, Huang H
Drug design, development and therapy 2020;14:1351-1362
Drug design, development and therapy 2020;14:1351-1362
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Wang Z, Cai L, Li H, Liang M, Zhang Y, Wu Q, Yang L
Journal of food biochemistry 2020 May;44(5):e13180
Journal of food biochemistry 2020 May;44(5):e13180
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Wang Z, Liang M, Li H, Cai L, He H, Wu Q, Yang L
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death.
Blecha J, Novais SM, Rohlenova K, Novotna E, Lettlova S, Schmitt S, Zischka H, Neuzil J, Rohlena J
Free radical biology & medicine 2017 Nov;112:253-266
Free radical biology & medicine 2017 Nov;112:253-266
GSH-dependent antioxidant defense contributes to the acclimation of colon cancer cells to acidic microenvironment.
Zhao M, Liu Q, Gong Y, Xu X, Zhang C, Liu X, Zhang C, Guo H, Zhang X, Gong Y, Shao C
Cell cycle (Georgetown, Tex.) 2016;15(8):1125-33
Cell cycle (Georgetown, Tex.) 2016;15(8):1125-33
The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.
Zheng ZG, Xu H, Suo SS, Xu XL, Ni MW, Gu LH, Chen W, Wang LY, Zhao Y, Tian B, Hua YJ
Scientific reports 2016 May 19;6:26093
Scientific reports 2016 May 19;6:26093
Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes.
Dong K, Wu M, Liu X, Huang Y, Zhang D, Wang Y, Yan LJ, Shi D
Free radical biology & medicine 2016 Dec;101:334-347
Free radical biology & medicine 2016 Dec;101:334-347
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Wu H, Xiao Y, Zhang S, Ji S, Wei L, Fan F, Geng J, Tian J, Sun X, Qin F, Jin C, Lin J, Yin ZY, Zhang T, Luo L, Li Y, Song S, Lin SC, Deng X, Camargo F, Avruch J, Chen L, Zhou D
Cell reports 2013 May 30;3(5):1663-77
Cell reports 2013 May 30;3(5):1663-77
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 18257-1-AP(GSR antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using GSR antibody 18257-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line