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- References [17]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 21223-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21223-1-AP, RRID:AB_10694574
- Product name
- SCO2 antibody
- Antibody type
- Polyclonal
- Description
- SCO2 antibody (Cat. #21223-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Bulk and Single-Cell Transcriptomics Reveal That SCO2 Drives Psoriasis via Activating CCR7(+) Dendritic Cell.
Asporin regulates glycolysis and stemness of gastric cancer cells.
PLZ4@SeD-induced ferroptosis sensitizes bladder cancer to chemotherapy and immunotherapy.
LRPPRC-Driven Oxidative Phosphorylation Is Associated with Elesclomol-Induced Cuproptosis in Ovarian Cancer.
Clioquinol induces mitochondrial toxicity in SH-SY5Y neuroblastoma cells by affecting the respiratory chain complex IV and OPA1 dynamin-like GTPase.
Dual targeting of wild-type p53 and gut microbiota by Magnolol represses key metabolic process and kills CRC cells.
FERMT1 suppression induces anti-tumor effects and reduces stemness in glioma cancer cells.
Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17.
Cancer-cell-secreted extracellular vesicles target p53 to impair mitochondrial function in muscle.
Repeated radon exposure induced epithelial-mesenchymal transition-like transformation via disruption of p53-dependent mitochondrial function.
Expression of SCO1 and SCO2 after form-deprivation myopia in Guinea pigs.
Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production.
SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner.
APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies.
Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53.
Chen D, Yang J, Zhou G, Xu X, Zhang Y, Duan Y, Liu B, Zhu Z, Zhou F
International journal of molecular sciences 2026 Jan 30;27(3)
International journal of molecular sciences 2026 Jan 30;27(3)
Asporin regulates glycolysis and stemness of gastric cancer cells.
Xu G, Cai Z, Zhuang Y, Wang H, Lin Q, Guo T, Tao H
Journal of molecular histology 2026 Feb 13;57(2):74
Journal of molecular histology 2026 Feb 13;57(2):74
PLZ4@SeD-induced ferroptosis sensitizes bladder cancer to chemotherapy and immunotherapy.
Liu X, Chen L, Lin L, Xie Y, Zheng J, Wang Z, He Z, Wang F, Zeng Q
Biomaterials advances 2026 Aug;185:214842
Biomaterials advances 2026 Aug;185:214842
LRPPRC-Driven Oxidative Phosphorylation Is Associated with Elesclomol-Induced Cuproptosis in Ovarian Cancer.
Wu Y, Zhang W, Jiang S, Liu S, Su J, Sun L
International journal of molecular sciences 2025 Dec 31;27(1)
International journal of molecular sciences 2025 Dec 31;27(1)
Clioquinol induces mitochondrial toxicity in SH-SY5Y neuroblastoma cells by affecting the respiratory chain complex IV and OPA1 dynamin-like GTPase.
Katsuyama M, Arakawa N, Yaoi T, Kimura E, Matsumoto M, Iwata K, Umemura A, Yabe-Nishimura C
FEBS letters 2025 Apr;599(8):1135-1145
FEBS letters 2025 Apr;599(8):1135-1145
Dual targeting of wild-type p53 and gut microbiota by Magnolol represses key metabolic process and kills CRC cells.
Ji H, Qiao O, Zhang Y, Wang W, Han X, Zhang X, Liu C, Gao W
Phytotherapy research : PTR 2024 Oct;38(10):4982-4998
Phytotherapy research : PTR 2024 Oct;38(10):4982-4998
FERMT1 suppression induces anti-tumor effects and reduces stemness in glioma cancer cells.
Pan Z, Ke C, Zheng H, Guo X, Gao W, Huang X, Chen C, Xiong Y, Zheng S, Zheng F, Hu W
Journal of cancer research and clinical oncology 2024 Jul 8;150(7):338
Journal of cancer research and clinical oncology 2024 Jul 8;150(7):338
Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17.
Huang D, Chen L, Ji Q, Xiang Y, Zhou Q, Chen K, Zhang X, Zou F, Zhang X, Zhao Z, Wang T, Zheng G, Meng X
Redox biology 2024 Feb;69:102990
Redox biology 2024 Feb;69:102990
Cancer-cell-secreted extracellular vesicles target p53 to impair mitochondrial function in muscle.
Ruan X, Cao M, Yan W, Jones YZ, Gustafsson ÅB, Patel HH, Schenk S, Wang SE
EMBO reports 2023 Sep 6;24(9):e56464
EMBO reports 2023 Sep 6;24(9):e56464
Repeated radon exposure induced epithelial-mesenchymal transition-like transformation via disruption of p53-dependent mitochondrial function.
Shan S, Chen X, Wang A, Yan W, Wu Q, Wan J, Hong C, Wang Y, Tong J, Tian H, Xin L
Toxicology research 2023 Dec;12(6):1143-1151
Toxicology research 2023 Dec;12(6):1143-1151
Expression of SCO1 and SCO2 after form-deprivation myopia in Guinea pigs.
Zhou G, Lan C, Yang Q, Zhong W, Gu Z, Xiang X, Mao Y, Liao X
European journal of ophthalmology 2022 Sep;32(5):3050-3057
European journal of ophthalmology 2022 Sep;32(5):3050-3057
Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production.
Yin K, Lee J, Liu Z, Kim H, Martin DR, Wu D, Liu M, Xue X
Cell death and differentiation 2021 Aug;28(8):2421-2435
Cell death and differentiation 2021 Aug;28(8):2421-2435
SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner.
Ramos H, Calheiros J, Almeida J, Barcherini V, Santos S, Carvalho ATP, Santos MMM, Saraiva L
International journal of molecular sciences 2020 Jan 17;21(2)
International journal of molecular sciences 2020 Jan 17;21(2)
APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.
Signes A, Cerutti R, Dickson AS, Benincá C, Hinchy EC, Ghezzi D, Carrozzo R, Bertini E, Murphy MP, Nathan JA, Viscomi C, Fernandez-Vizarra E, Zeviani M
EMBO molecular medicine 2019 Jan;11(1)
EMBO molecular medicine 2019 Jan;11(1)
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
Liu F, Zhang W, You X, Liu Y, Li Y, Wang Z, Wang Y, Zhang X, Ye L
Oncotarget 2015 Sep 29;6(29):27199-213
Oncotarget 2015 Sep 29;6(29):27199-213
Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies.
Pacheu-Grau D, Bareth B, Dudek J, Juris L, Vögtle FN, Wissel M, Leary SC, Dennerlein S, Rehling P, Deckers M
Cell metabolism 2015 Jun 2;21(6):823-33
Cell metabolism 2015 Jun 2;21(6):823-33
Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53.
Napoli E, Ross-Inta C, Wong S, Hung C, Fujisawa Y, Sakaguchi D, Angelastro J, Omanska-Klusek A, Schoenfeld R, Giulivi C
PloS one 2012;7(8):e42504
PloS one 2012;7(8):e42504
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 21223-1-AP(SCO2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 21223-1-AP(SCO2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SCO2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SCO2. This antibody recognizes human, mouse antigen. The SCO2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
