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Learn12-0628-42
antibody from Invitrogen Antibodies
Targeting: SELP
CD62, CD62P, GMP140, GRMP, PADGEM, PSEL
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 12-0628-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD62P (P-Selectin) Monoclonal Antibody (AK-4), PE, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The AK-4 monoclonal antibody reacts with human CD62P, a 140 kDa transmembrane glycoprotein also known as P-Selectin. Upon activation, CD62P is rapidly transported from its cytoplasmic stores in the Weibel-Palade bodies of endothelial cells or the alpha-granules of platelets to the surface. CD62P initiates the adhesive interaction between endothelial cells and neutrophils and monocytes during the inflammatory reaction and is also involved in the interaction of platelets with monocytes and neutrophils.
- Conjugate
- Yellow dye
- Antibody clone number
- AK-4
- Concentration
- 5 µL/Test
Submitted references Sex-Specific Platelet Activation Through Protease-Activated Receptors Reverses in Myocardial Infarction.
Platelets Fuel the Inflammasome Activation of Innate Immune Cells.
High-resolution crystal structure of human protease-activated receptor 1.
Soo Kim B, Auerbach DS, Sadhra H, Godwin M, Bhandari R, Ling FS, Mohan A, Yule DI, Wagner L 2nd, Rich DQ, Ture S, Morrell CN, Timpanaro-Perrotta L, Younis A, Goldenberg I, Cameron SJ
Arteriosclerosis, thrombosis, and vascular biology 2021 Jan;41(1):390-400
Arteriosclerosis, thrombosis, and vascular biology 2021 Jan;41(1):390-400
Platelets Fuel the Inflammasome Activation of Innate Immune Cells.
Rolfes V, Ribeiro LS, Hawwari I, Böttcher L, Rosero N, Maasewerd S, Santos MLS, Próchnicki T, Silva CMS, Wanderley CWS, Rothe M, Schmidt SV, Stunden HJ, Bertheloot D, Rivas MN, Fontes CJ, Carvalho LH, Cunha FQ, Latz E, Arditi M, Franklin BS
Cell reports 2020 May 12;31(6):107615
Cell reports 2020 May 12;31(6):107615
High-resolution crystal structure of human protease-activated receptor 1.
Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK
Nature 2012 Dec 20;492(7429):387-92
Nature 2012 Dec 20;492(7429):387-92
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of human peripheral blood mononuclear cells with CD45 Pacific Blue, CD41 APC and CD62P PE. As expected based on known relative expression patterns, CD62P clone AK-4 stains a subset of CD45 negative cells (green), but not lymphocytes (pink), monocytes (orange) and granulocytes (blue).
- Conjugate
- Yellow dye
