60299-1-Ig

antibody from Proteintech Group

Targeting: ICAM1 BB2, CD54

Provider product page for 60299-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [48]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 60299-1-Ig - Provider product page
Provider: Proteintech Group
Product name: Icam-1 antibody
Antibody type: Monoclonal
Description: KD/KO validated ICAM-1 antibody (Cat. #60299-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2F9A8
Vial size: 20ul, 150ul

ICAM1 protein structure - 60299-1-Ig shown in red.

Submitted references RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.

He S, Lu M, Zhang L, Wang Z
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Proteomic Characterization Identifies Clinically Relevant Subgroups of Gastrointestinal Stromal Tumors.

Sun M, Tong Y, Yuan W, Wang Y, Pu Y, Huang W, Lv B, Xu C, Jiang W, Luo R, Fang R, Tang S, Ren L, Wang J, Feng J, Sun C, Shen K, He F, Hou Y, Ding C
Gastroenterology 2024 Mar;166(3):450-465.e33

IL-21 promoting angiogenesis contributes to the development of psoriasis.

Han D, Li F, Zhao Y, Wang B, Wang J, Liu B, Mou K, Meng L, Zheng Y, Lu S, Zhu W, Zhou Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23375

The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E (-/-) mice.

Mu X, Liu SJ, Zheng LY, Ouyang C, Abdalla AME, Wang XX, Chen K, Yang FF, Meng N
Free radical biology & medicine 2024 Apr;216:106-117

Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury.

Zhang J, Luan ZL, Huo XK, Zhang M, Morisseau C, Sun CP, Hammock BD, Ma XC
International journal of biological sciences 2023;19(1):294-310

Identification and characterization of a new variation in DPM2 gene in two Chinese siblings with mild intellectual impairment.

Zhao P, Hu Y, Hu J, Li C, Huang Y, Zhang L, Luo S, Zhu H, Jiang J, He X
Frontiers in genetics 2023;14:930692

Possible roles of human mast cells in the formation of xanthelasma palpebrarum.

Nakamura H, Matsuzaki T, Ito KR, Nakagawa R, Asano LM, Nishikido H, Haga H, Kataoka TR
Pathology international 2023 Sep;73(9):406-412

A CCL2(+)DPP4(+) subset of mesenchymal stem cells expedites aberrant formation of creeping fat in humans.

Wu F, Wu F, Zhou Q, Liu X, Fei J, Zhang D, Wang W, Tao Y, Lin Y, Lin Q, Pan X, Sun K, Xie F, Bai L
Nature communications 2023 Sep 20;14(1):5830

Macrophage microvesicle-derived circ_YTHDF2 in methamphetamine-induced chronic lung injury.

Chen L, Gu YJ, Zhang XG, Cheng L, Zhou MY, Yang Y, Wang Y
The Journal of physiology 2023 Nov;601(22):5107-5128

CDK4/6 inhibition triggers ICAM1-driven immune response and sensitizes LKB1 mutant lung cancer to immunotherapy.

Bai X, Guo ZQ, Zhang YP, Fan ZZ, Liu LJ, Liu L, Long LL, Ma SC, Wang J, Fang Y, Tang XR, Zeng YJ, Pan X, Wu DH, Dong ZY
Nature communications 2023 Mar 4;14(1):1247

Endothelial-derived complement factor D contributes to endothelial dysfunction in malignant nephrosclerosis via local complement activation.

Wang Z, Zhang Z, Li Y, Zhang Y, Wei M, Li H, Yang S, Zhou Y, Zhou X, Xing G
Hypertension research : official journal of the Japanese Society of Hypertension 2023 Jul;46(7):1759-1770

High mobility group box 1 derived mainly from platelet microparticles exacerbates microvascular obstruction in no reflow.

Zhao X, Han J, Zhou L, Zhao J, Huang M, Wang Y, Kou J, Kou Y, Jin J
Thrombosis research 2023 Feb;222:49-62

Proteomic and single-cell landscape reveals novel pathogenic mechanisms of HBV-infected intrahepatic cholangiocarcinoma.

Shen Y, Xu S, Ye C, Li Q, Chen R, Wu W, Jiang Q, Jia Y, Zhang X, Fan L, Fu W, Jiang M, Chen J, Timko MP, Zhao P, Ruan J
iScience 2023 Feb 17;26(2):106003

SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication.

Montezano AC, Camargo LL, Mary S, Neves KB, Rios FJ, Stein R, Lopes RA, Beattie W, Thomson J, Herder V, Szemiel AM, McFarlane S, Palmarini M, Touyz RM
Scientific reports 2023 Aug 28;13(1):14086

Cadherin-16 inhibits thyroid carcinoma cell proliferation and invasion.

Yang X, Li Y, Liu G, Zha W, Liu Y
Oncology letters 2022 May;23(5):145

SIRT6 mediates MRTF-A deacetylation in vascular endothelial cells to antagonize oxLDL-induced ICAM-1 transcription.

Huang S, Shao T, Liu H, Wang Q, Li T, Zhao Q
Cell death discovery 2022 Mar 4;8(1):96

Eplerenone inhibits the macrophage-to-myofibroblast transition in rats with UUO-induced type 4 cardiorenal syndrome through the MR/CTGF pathway.

Han Y, Xian Y, Gao X, Qiang P, Hao J, Yang F, Shimosawa T, Chang Y, Xu Q
International immunopharmacology 2022 Dec;113(Pt A):109396

MAC mediates mammary duct epithelial cell injury in plasma cell mastitis and granulomatous mastitis.

Zhang HJ, Ding PP, Zhang XS, Wang XC, Sun DW, Bu QA, Li XQ
International immunopharmacology 2022 Dec;113(Pt A):109303

Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling.

Xue Y, Luo M, Hu X, Li X, Shen J, Zhu W, Huang L, Hu Y, Guo Y, Liu L, Wang L, Luo S
Communications biology 2022 Dec 1;5(1):1316

Indispensable role of mitochondria in maintaining the therapeutic potential of curcumin in acute kidney injury.

Li L, Liu S, Zhou Y, Zhao M, Wang Y, Wang C, Lou P, Huang R, Ma L, Lu Y, Fu P, Liu J
Journal of cellular and molecular medicine 2021 Oct;25(20):9863-9877

Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis.

Li Z, Li Q, Wang L, Li C, Xu M, Duan Y, Ma L, Li T, Chen Q, Wang Y, Wang Y, Feng J, Yin X, Wang X, Han J, Lu C
Redox biology 2021 Nov;47:102156

Direct Activation of Endothelial Cells by SARS-CoV-2 Nucleocapsid Protein Is Blocked by Simvastatin.

Qian Y, Lei T, Patel PS, Lee CH, Monaghan-Nichols P, Xin HB, Qiu J, Fu M
Journal of virology 2021 Nov 9;95(23):e0139621

Hematopoietic progenitors polarize in contact with bone marrow stromal cells in response to SDF1.

Bessy T, Candelas A, Souquet B, Saadallah K, Schaeffer A, Vianay B, Cuvelier D, Gobaa S, Nakid-Cordero C, Lion J, Bories JC, Mooney N, Jaffredo T, Larghero J, Blanchoin L, Faivre L, Brunet S, Théry M
The Journal of cell biology 2021 Nov 1;220(11)

CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis.

Zhang X, Lu J, Zhang Q, Luo Q, Liu B
Biological research 2021 Mar 23;54(1):11

Protection against Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Neferine, A Natural Product from Nelumbo nucifera Gaertn.

Min X, Guo Y, Zhou Y, Chen X
Cell journal 2021 Jan;22(4):523-531

Direct activation of endothelial cells by SARS-CoV-2 nucleocapsid protein is blocked by Simvastatin.

Qian Y, Lei T, Patel PS, Lee CH, Monaghan-Nichols P, Xin HB, Qiu J, Fu M
bioRxiv : the preprint server for biology 2021 Feb 18;

Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells.

Hou JR, Wang YH, Zhong YN, Che TT, Hu Y, Bao J, Meng N
Marine drugs 2021 Dec 18;19(12)

VAMP3 and SNAP23 as Potential Targets for Preventing the Disturbed Flow-Accelerated Thrombus Formation.

Zhu JJ, Jiang ZT, Liu C, Xi YF, Wang J, Yang FF, Yao WJ, Pang W, Han LL, Zhang YH, Sun AQ, Zhou J
Frontiers in cell and developmental biology 2020;8:576826

Rhodiola crenulata Suppresses High Glucose-Induced Matrix Metalloproteinase Expression and Inflammatory Responses by Inhibiting ROS-Related HMGB1-TLR4 Signaling in Endothelial Cells.

Huang LY, Yen IC, Tsai WC, Lee SY
The American journal of Chinese medicine 2020;48(1):91-105

Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth.

Leng L, Ma J, Lv L, Wang W, Gao D, Zhu Y, Wu Z
Stem cell research & therapy 2020 Sep 23;11(1):415

Synergistic Effect of Combined Artesunate and Tetramethylpyrazine in Experimental Cerebral Malaria.

Jiang X, Chen L, Zheng Z, Chen Y, Weng X, Guo Y, Li K, Yang T, Qu S, Liu H, Li Y, Zhu X
ACS infectious diseases 2020 Sep 11;6(9):2400-2409

Interactions between neutrophil extracellular traps and activated platelets enhance procoagulant activity in acute stroke patients with ICA occlusion.

Zhou P, Li T, Jin J, Liu Y, Li B, Sun Q, Tian J, Zhao H, Liu Z, Ma S, Zhang S, Novakovic VA, Shi J, Hu S
EBioMedicine 2020 Mar;53:102671

Mussel adhesive protein fused with VE-cadherin extracellular domain promotes endothelial-cell tight junctions and in vivo endothelization recovery of vascular stent.

Yang D, Yan W, Qiu J, Huang Y, Li T, Wang Y, Wang N, Durkan C, Huang J, Yin T, Wang G
Journal of biomedical materials research. Part B, Applied biomaterials 2020 Jan;108(1):94-103

Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3.

Lin T, Luo W, Li Z, Zhang L, Zheng X, Mai L, Yang W, Guan G, Su Z, Liu P, Li Z, Xie Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153350

Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy.

Zheng XY, Sun CC, Liu Q, Lu XY, Fu LL, Liang G, Zhang XH, Chen GZ
Acta pharmacologica Sinica 2020 Aug;41(8):1093-1101

Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats.

Zhang HF, Wang JH, Wang YL, Gao C, Gu YT, Huang J, Wang JH, Zhang Z
Oxidative medicine and cellular longevity 2019;2019:2853534

20(S)-Protopanaxadiol Saponins Mainly Contribute to the Anti-Atherogenic Effects of Panax notoginseng in ApoE Deficient Mice.

Liu C, Feng R, Zou J, Xia F, Wan JB
Molecules (Basel, Switzerland) 2019 Oct 16;24(20)

Extracts of Coleus forskohlii relieves cough and asthma symptoms via modulating inflammation and the extracellular matrix.

Ma C, Zou L, Xia Y, Tu Y, Xue D, Yang Y, Liu D, Liu Y, Wu H, Dan H, You P
Journal of cellular biochemistry 2019 Jun;120(6):9648-9655

A Synthesized Glucocorticoid- Induced Leucine Zipper Peptide Inhibits Retinal Müller Cell Gliosis.

Gu R, Ding X, Tang W, Lei B, Jiang C, Xu G
Frontiers in pharmacology 2018;9:331

Salvianolic acid A attenuates kidney injury and inflammation by inhibiting NF-κB and p38 MAPK signaling pathways in 5/6 nephrectomized rats.

Zhang HF, Wang YL, Gao C, Gu YT, Huang J, Wang JH, Wang JH, Zhang Z
Acta pharmacologica Sinica 2018 Dec;39(12):1855-1864

Metformin ameliorates the progression of atherosclerosis via suppressing macrophage infiltration and inflammatory responses in rabbits.

Yang Q, Yuan H, Chen M, Qu J, Wang H, Yu B, Chen J, Sun S, Tang X, Ren W
Life sciences 2018 Apr 1;198:56-64

TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H(2)S System.

Peng J, Tang ZH, Ren Z, He B, Zeng Y, Liu LS, Wang Z, Wei DH, Zheng XL, Jiang ZS
Frontiers in pharmacology 2017;8:486

Tail vein injection of mmLDL upregulates mouse mesenteric artery ET(B) receptors via activation of the ERK1/2 pathway.

Liu Y, Chen XL, Xu CB, Cao L, Lin J, Chen G, Li J
Vascular pharmacology 2017 Sep;96-98:33-39

2,3',4,4',5-Pentachlorobiphenyl Induces Inflammatory Responses in the Thyroid Through JNK and Aryl Hydrocarbon Receptor-Mediated Pathway.

Xu B, Yang H, Sun M, Chen H, Jiang L, Zheng X, Ding G, Liu Y, Sheng Y, Cui D, Duan Y
Toxicological sciences : an official journal of the Society of Toxicology 2016 Feb;149(2):300-11

A hot water extract of Curcuma longa inhibits adhesion molecule protein expression and monocyte adhesion to TNF-α-stimulated human endothelial cells.

Kawasaki K, Muroyama K, Yamamoto N, Murosaki S
Bioscience, biotechnology, and biochemistry 2015;79(10):1654-9

Anti-TNF-α monoclonal antibody reverses psoriasis through dual inhibition of inflammation and angiogenesis.

Liu Y, Yang G, Zhang J, Xing K, Dai L, Cheng L, Liu J, Deng J, Shi G, Li C, Su X, Zhang S, Yang Y, Li J, Yu D, Xiang R, Wei Y, Deng H
International immunopharmacology 2015 Sep;28(1):731-43

Paracrine Met signaling triggers epithelial-mesenchymal transition in mammary luminal progenitors, affecting their fate.

Di-Cicco A, Petit V, Chiche A, Bresson L, Romagnoli M, Orian-Rousseau V, Vivanco Md, Medina D, Faraldo MM, Glukhova MA, Deugnier MA
eLife 2015 Jul 13;4

Retinylamine Benefits Early Diabetic Retinopathy in Mice.

Liu H, Tang J, Du Y, Lee CA, Golczak M, Muthusamy A, Antonetti DA, Veenstra AA, Amengual J, von Lintig J, Palczewski K, Kern TS
The Journal of biological chemistry 2015 Aug 28;290(35):21568-79

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Raji cells were subjected to SDS PAGE followed by western blot with 60299-1-Ig( ICAM-1 Antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ICAM-1 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human ICAM-1. This antibody recognizes human, rat antigen. The ICAM-1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Appendix: 60299-1-Ig.pdf

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