RA0299

antibody from Oursmab

Targeting: ICAM1 BB2, CD54

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0299

Provider

Oursmab

Product name

Bersanlimab (Biosimilar Reference Antibody) (ICAM1)

Antibody type

Monoclonal

Description

Bersanlimab (also known as BI-505) is a fully human monoclonal antibody of the IgG1 isotype. It is designed as an antineoplastic agent that targets the Intercellular Adhesion Molecule 1 (ICAM-1 or CD54). Its primary mechanism of action is the direct induction of programmed cell death (apoptosis) in tumor cells that express ICAM-1. The antibody binding is thought to trigger specific signaling pathways within the malignant cell, leading to caspase activation and cell death, independent of complement or host effector cells. It has been primarily investigated for the treatment of hematological malignancies, such as multiple myeloma and non-Hodgkin's lymphoma, where ICAM-1 is often overexpressed.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.