Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- BMS109 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD102 (ICAM-2) Monoclonal Antibody (CBR-IC2/2), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: BMS109 does not cross react with mouse. Intercellular Adhesion Molecule-2 (ICAM-2) is a 60 kDa surface glycoprotein that promotes adhesion between immune cells and the vascular endothelium. ICAM-2 is a member of the Ig-superfamily with two immunoglobulin-like extracellular domains. ICAM-2 is much more closely related to the two N-terminal domains of ICAM-1 (34% identity) than either ICAM-1 or ICAM-2 is to other members of the Ig-superfamily, demonstrating the existence of a subfamily of Ig-like ligands that bind the same integrin receptor. ICAM-2 is broadly distributed on hematopoietic cells. On resting lymphocytes, the ICAM-2 expression is several-fold higher than that seen with ICAM-1, while monocytes express equivalent levels of ICAM-1 and ICAM-2. In contrast to ICAM-1, neutrophils stain negative for ICAM-2. Just little or no ICAM-2 staining can be demonstrated on other cell lines, the sole exception being resting vascular endothelial cells, which possess high levels of ICAM-2, and small clusters of cells in lymphoid tissue germinal centres. ICAM-2 expression is unaffected by a variety of inflammatory cytokines. Applications Tested: ELISA, Flow Cytometry, Functional Studies (Blocking), Immunohistochemistry. Purity: >95%.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- CBR-IC2/2
- Vial size
- 50 µg
- Concentration
- 0.5 mg/mL
- Storage
- 4° C
Submitted references Surgical and intravital microscopy protocol to image Trypanosoma brucei-host interactions in live rodent models.
Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence.
De Niz M, Figueiredo LM
STAR protocols 2022 Jun 17;3(2):101450
STAR protocols 2022 Jun 17;3(2):101450
Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence.
De Niz M, Brás D, Ouarné M, Pedro M, Nascimento AM, Henao Misikova L, Franco CA, Figueiredo LM
Cell reports 2021 Sep 21;36(12):109741
Cell reports 2021 Sep 21;36(12):109741
No comments: Submit comment
No validations: Submit validation data