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- Antibody Data
- Antigen structure
- References [35]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11176-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11176-1-AP, RRID:AB_2117177
- Product name
- HNRNPA1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HNRNPA1 antibody (Cat. #11176-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, pig and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references RNA damage compartmentalization by DHX9 stress granules.
Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human.
SINE-Associated LncRNA SAWPA Regulates Porcine Zygotic Genome Activation.
hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.
M2 Macrophage-Derived Exosomal lncRNA MIR4435-2HG Promotes Progression of Infantile Hemangiomas by Targeting HNRNPA1.
hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA.
Increase in hnRNPA1 Expression Suffices to Kill Motor Neurons in Transgenic Rats.
β-Hydroxybutyrate alleviates cartilage senescence through hnRNP A1-mediated up-regulation of PTEN.
A splicing silencer in SMN2 intron 6 is critical in spinal muscular atrophy.
N protein of PEDV plays chess game with host proteins by selective autophagy.
The hnRNPK/A1/R/U Complex Regulates Gene Transcription and Translation and is a Favorable Prognostic Biomarker for Human Colorectal Adenocarcinoma.
Position-dependent effects of hnRNP A1/A2 in SMN1/2 exon7 splicing.
Kaempferol Can Reverse the 5-Fu Resistance of Colorectal Cancer Cells by Inhibiting PKM2-Mediated Glycolysis.
Rescue of mis-splicing of a common SLC26A4 mutant associated with sensorineural hearing loss by antisense oligonucleotides.
Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export.
Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications.
Compensatory expression regulation of highly homologous proteins HNRNPA1 and HNRNPA2.
Esculetin inhibits endometrial cancer proliferation and promotes apoptosis via hnRNPA1 to downregulate BCLXL and XIAP.
Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth.
Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells.
An APEX2 proximity ligation method for mapping interactions with the nuclear lamina.
hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity.
In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs.
E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing.
Novel Non-Coding Transcript in NR4A3 Locus, LncNR4A3, Regulates RNA Processing Machinery Proteins and NR4A3 Expression.
Long Non-coding RNA HOTAIR Function as a Competing Endogenous RNA for miR-149-5p to Promote the Cell Growth, Migration, and Invasion in Non-small Cell Lung Cancer.
Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates.
A novel miR-206/hnRNPA1/PKM2 axis reshapes the Warburg effect to suppress colon cancer growth.
Transcriptome profiling reveals the high incidence of hnRNPA1 exon 8 inclusion in chronic myeloid leukemia.
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth.
Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells.
HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.
Two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification (iTRAQ) labeling approach revealed first proteome profiles of pulmonary alveolar macrophages infected with porcine reproductive and respiratory syndrome virus.
Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs.
Zhou Y, Panhale A, Shvedunova M, Balan M, Gomez-Auli A, Holz H, Seyfferth J, Helmstädter M, Kayser S, Zhao Y, Erdogdu NU, Grzadzielewska I, Mittler G, Manke T, Akhtar A
Cell 2024 Mar 28;187(7):1701-1718.e28
Cell 2024 Mar 28;187(7):1701-1718.e28
Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human.
Huang W, Xiong T, Zhao Y, Heng J, Han G, Wang P, Zhao Z, Shi M, Li J, Wang J, Wu Y, Liu F, Xi JJ, Wang Y, Zhang QC
Nature genetics 2024 Jan;56(1):124-135
Nature genetics 2024 Jan;56(1):124-135
SINE-Associated LncRNA SAWPA Regulates Porcine Zygotic Genome Activation.
He T, Peng J, Yang S, Liu D, Gao S, Zhu Y, Chai Z, Lee BC, Wei R, Wang J, Liu Z, Jin JX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(2):e2307505
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(2):e2307505
hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility.
Wang X, Fan X, Zhang J, Wang F, Chen J, Wen Y, Wang L, Li T, Li H, Gu H, Zhang Y, Yuan S
Cell reports 2024 Feb 27;43(2):113769
Cell reports 2024 Feb 27;43(2):113769
M2 Macrophage-Derived Exosomal lncRNA MIR4435-2HG Promotes Progression of Infantile Hemangiomas by Targeting HNRNPA1.
Li Z, Cao Z, Li N, Wang L, Fu C, Huo R, Xu G, Tian C, Bi J
International journal of nanomedicine 2023;18:5943-5960
International journal of nanomedicine 2023;18:5943-5960
hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA.
Zhang Q, Weng W, Gu X, Xiang J, Yang Y, Zhu MX, Gu W, He Z, Li Y
Cell reports 2023 Nov 28;42(11):113401
Cell reports 2023 Nov 28;42(11):113401
Increase in hnRNPA1 Expression Suffices to Kill Motor Neurons in Transgenic Rats.
Huang B, Liu X, Zhang T, Wu Q, Huang C, Xia XG, Zhou H
International journal of molecular sciences 2023 Nov 11;24(22)
International journal of molecular sciences 2023 Nov 11;24(22)
β-Hydroxybutyrate alleviates cartilage senescence through hnRNP A1-mediated up-regulation of PTEN.
Xia G, Wen Z, Zhang L, Huang J, Wang X, Liang C, Cui X, Cao X, Wu S
Experimental gerontology 2023 May;175:112140
Experimental gerontology 2023 May;175:112140
A splicing silencer in SMN2 intron 6 is critical in spinal muscular atrophy.
Wang L, Ji Y, Chen Y, Bai J, Gao P, Feng P
Human molecular genetics 2023 Mar 6;32(6):971-983
Human molecular genetics 2023 Mar 6;32(6):971-983
N protein of PEDV plays chess game with host proteins by selective autophagy.
Zhai X, Kong N, Zhang Y, Song Y, Qin W, Yang X, Ye C, Ye M, Tong W, Liu C, Zheng H, Yu H, Zhang W, Yang X, Zhang G, Tong G, Shan T
Autophagy 2023 Aug;19(8):2338-2352
Autophagy 2023 Aug;19(8):2338-2352
The hnRNPK/A1/R/U Complex Regulates Gene Transcription and Translation and is a Favorable Prognostic Biomarker for Human Colorectal Adenocarcinoma.
Li Y, Wang H, Wan J, Ma Q, Qi Y, Gu Z
Frontiers in oncology 2022;12:845931
Frontiers in oncology 2022;12:845931
Position-dependent effects of hnRNP A1/A2 in SMN1/2 exon7 splicing.
Qiu J, Qu R, Lin M, Xu J, Zhu Q, Zhang Z, Sun J
Biochimica et biophysica acta. Gene regulatory mechanisms 2022 Nov;1865(8):194875
Biochimica et biophysica acta. Gene regulatory mechanisms 2022 Nov;1865(8):194875
Kaempferol Can Reverse the 5-Fu Resistance of Colorectal Cancer Cells by Inhibiting PKM2-Mediated Glycolysis.
Wu H, Du J, Li C, Li H, Guo H, Li Z
International journal of molecular sciences 2022 Mar 24;23(7)
International journal of molecular sciences 2022 Mar 24;23(7)
Rescue of mis-splicing of a common SLC26A4 mutant associated with sensorineural hearing loss by antisense oligonucleotides.
Feng P, Xu Z, Chen J, Liu M, Zhao Y, Wang D, Han L, Wang L, Wan B, Xu X, Li D, Shu Y, Hua Y
Molecular therapy. Nucleic acids 2022 Jun 14;28:280-292
Molecular therapy. Nucleic acids 2022 Jun 14;28:280-292
Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export.
Duan L, Zaepfel BL, Aksenova V, Dasso M, Rothstein JD, Kalab P, Hayes LR
Cell reports 2022 Jul 19;40(3):111106
Cell reports 2022 Jul 19;40(3):111106
Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications.
Pacetti M, De Conti L, Marasco LE, Romano M, Rashid MM, Nubiè M, Baralle FE, Baralle M
Disease models & mechanisms 2022 Apr 1;15(4)
Disease models & mechanisms 2022 Apr 1;15(4)
Compensatory expression regulation of highly homologous proteins HNRNPA1 and HNRNPA2.
Chang Y, Lu X, Qiu J
Turkish journal of biology = Turk biyoloji dergisi 2021;45(2):187-195
Turkish journal of biology = Turk biyoloji dergisi 2021;45(2):187-195
Esculetin inhibits endometrial cancer proliferation and promotes apoptosis via hnRNPA1 to downregulate BCLXL and XIAP.
Jiang R, Su G, Chen X, Chen S, Li Q, Xie B, Zhao Y
Cancer letters 2021 Sep 1;521:308-321
Cancer letters 2021 Sep 1;521:308-321
Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth.
Li WJ, He YH, Yang JJ, Hu GS, Lin YA, Ran T, Peng BL, Xie BL, Huang MF, Gao X, Huang HH, Zhu HH, Ye F, Liu W
Nature communications 2021 Mar 29;12(1):1946
Nature communications 2021 Mar 29;12(1):1946
Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells.
Wu H, Cui M, Li C, Li H, Dai Y, Cui K, Li Z
Journal of agricultural and food chemistry 2021 Mar 17;69(10):3060-3068
Journal of agricultural and food chemistry 2021 Mar 17;69(10):3060-3068
An APEX2 proximity ligation method for mapping interactions with the nuclear lamina.
Tran JR, Paulson DI, Moresco JJ, Adam SA, Yates JR, Goldman RD, Zheng Y
The Journal of cell biology 2021 Jan 4;220(1)
The Journal of cell biology 2021 Jan 4;220(1)
hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity.
Akinyemi AR, Li D, Zhang J, Liu Q
Neuroscience letters 2021 Apr 23;751:135824
Neuroscience letters 2021 Apr 23;751:135824
In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs.
Sun L, Li P, Ju X, Rao J, Huang W, Ren L, Zhang S, Xiong T, Xu K, Zhou X, Gong M, Miska E, Ding Q, Wang J, Zhang QC
Cell 2021 Apr 1;184(7):1865-1883.e20
Cell 2021 Apr 1;184(7):1865-1883.e20
E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing.
Chen D, Wang Y, Lu R, Jiang X, Chen X, Meng N, Chen M, Xie S, Yan GR
Theranostics 2020;10(19):8558-8572
Theranostics 2020;10(19):8558-8572
Novel Non-Coding Transcript in NR4A3 Locus, LncNR4A3, Regulates RNA Processing Machinery Proteins and NR4A3 Expression.
Congrains A, Niemann FS, Duarte ADSS, Ferro KPV, Olalla-Saad ST
Frontiers in oncology 2020;10:569668
Frontiers in oncology 2020;10:569668
Long Non-coding RNA HOTAIR Function as a Competing Endogenous RNA for miR-149-5p to Promote the Cell Growth, Migration, and Invasion in Non-small Cell Lung Cancer.
Li H, Cui Z, Lv X, Li J, Gao M, Yang Z, Bi Y, Zhang Z, Wang S, Li S, Zhou B, Yin Z
Frontiers in oncology 2020;10:528520
Frontiers in oncology 2020;10:528520
Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates.
Aarum J, Cabrera CP, Jones TA, Rajendran S, Adiutori R, Giovannoni G, Barnes MR, Malaspina A, Sheer D
EMBO reports 2020 Oct 5;21(10):e49585
EMBO reports 2020 Oct 5;21(10):e49585
A novel miR-206/hnRNPA1/PKM2 axis reshapes the Warburg effect to suppress colon cancer growth.
Fu R, Yang P, Amin S, Li Z
Biochemical and biophysical research communications 2020 Oct 22;531(4):465-471
Biochemical and biophysical research communications 2020 Oct 22;531(4):465-471
Transcriptome profiling reveals the high incidence of hnRNPA1 exon 8 inclusion in chronic myeloid leukemia.
Li SQ, Liu J, Zhang J, Wang XL, Chen D, Wang Y, Xu YM, Huang B, Lin J, Li J, Wang XZ
Journal of advanced research 2020 Jul;24:301-310
Journal of advanced research 2020 Jul;24:301-310
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Wen J, Lv R, Ma H, Shen H, He C, Wang J, Jiao F, Liu H, Yang P, Tan L, Lan F, Shi YG, He C, Shi Y, Diao J
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth.
Huang JZ, Chen M, Chen D, Gao XC, Zhu S, Huang H, Hu M, Zhu H, Yan GR
Molecular cell 2017 Oct 5;68(1):171-184.e6
Molecular cell 2017 Oct 5;68(1):171-184.e6
Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells.
Chen K, Huang C, Yuan J, Cheng H, Zhou R
Molecular biology and evolution 2014 Aug;31(8):2194-211
Molecular biology and evolution 2014 Aug;31(8):2194-211
HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.
Guo R, Li Y, Ning J, Sun D, Lin L, Liu X
PloS one 2013;8(4):e62729
PloS one 2013;8(4):e62729
Two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification (iTRAQ) labeling approach revealed first proteome profiles of pulmonary alveolar macrophages infected with porcine reproductive and respiratory syndrome virus.
Lu Q, Bai J, Zhang L, Liu J, Jiang Z, Michal JJ, He Q, Jiang P
Journal of proteome research 2012 May 4;11(5):2890-903
Journal of proteome research 2012 May 4;11(5):2890-903
Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs.
Markus MA, Marques FZ, Morris BJ
PloS one 2011;6(12):e28926
PloS one 2011;6(12):e28926
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 11176-1-AP(HNRNPA1 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HNRNPA1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HNRNPA1. This antibody recognizes human,mouse,rat antigen. The HNRNPA1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
