66519-1-Ig

antibody from Proteintech Group

Targeting: ITGAM CD11B, CR3A, MAC-1

Provider product page for 66519-1-Ig

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Product number: 66519-1-Ig - Provider product page
Provider: Proteintech Group
Product name: CD11B/Integrin Alpha M antibody
Antibody type: Monoclonal
Description: CD11B/Integrin Alpha M antibody (Cat. #66519-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1C7C2
Vial size: 20ul, 150ul

ITGAM protein structure - 66519-1-Ig shown in red.

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International journal of molecular sciences 2026 Jan 8;27(2)

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Apoptosis : an international journal on programmed cell death 2026 Feb 9;31(2):67

KANK4 Regulates CXCL16 Glycosylation Through TMEM260 to Modulate Microglial Activation in Sepsis-associated Encephalopathy.

Peng M, Tan S, Li A, Guo Q, Liu L
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Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation.

Huo S, Wang M, Du M, Ren B, Yang T, Peng L, Jiang Y, Peng D, Men L, Shi W, Guo J, Zhang C, Lv J, Li S, Lin L
International journal of biological sciences 2025;21(7):3061-3080

Iron-Oxide Labeled Stem Cells with Specific Magnetic Occurrence for Effective in Mouse Model of Cisplatin-Induced Acute Kidney Injury.

Wang K, Zhao Y, Lv H, Li X
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The TMBIM1-YBX1 axis orchestrates MDSC recruitment and immunosuppressive microenvironment in pancreatic cancer.

Tong X, Xiao M, Yang J, Xu J, Wang W, Yu X, Shi S
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Baicalein suppresses the malignant progression of acute myeloid leukemia via ROS-dependent metabolic reprogramming: Mechanisms of differentiation induction and ferroptosis activation.

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Interleukin-10 Modified Human Mesenchymal Stromal Cells Markedly Alleviated Periodontitis by Inducing Macrophage M2 Polarisation.

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M2 macrophages activate the IL-10/JAK2/STAT3 pathway to induce pathological microangiogenesis in the nucleus pulposus exacerbating intervertebral disc degeneration.

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Cheng H, Shao Y, Zhang A, Li C, Li X, Fu Y, Ming J
Scientific reports 2025 May 15;15(1):16869

Chemotherapy-induced macrophage CXCL7 expression drives tumor chemoresistance via the STAT1/PHGDH-serine metabolism axis and SAM paracrine feedback to M2 polarization.

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Chen B, Fan H, Pang X, Shen Z, Gao R, Wang H, Yu Z, Li T, Li M, Tang Y, Liang X
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Liu K, Shao J, Han B, Liu J, Yan S, Liu B, Liu Y
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Cai YJ, Lan JH, Li S, Feng YN, Li FH, Guo MY, Liu RP
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Liu Y, He W, Li X, Lu X, Wu C, Gao Y, Fan D, Dong C, Zhao H
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Xia Y, Zhang Y, Ji J, Feng G, Chen T, Li H, Zhou F, Bao Y, Zeng X, Gu Z
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Lin J, Wang C, Yang G, Liu Y, Da Y, Zhou W, Zhou H, Wang F, Fan Z, Hou L, Wu T, Wu K, Liang J
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Cui K, Hu S, Zha Y, Ding K, Wei H, Cheng M, Mei X
British journal of cancer 2025 Aug;133(3):295-304

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Wang M, Wang Y, Zhang P, Gu C, Zhao X, Gong X, Yang X, Pan J, Xi Y
Acta biomaterialia 2025 Apr;196:487-505

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Zhou X, Zhu D, Wu D, Li G, Liang H, Zhang W, Wu Y, Xu H, Zhang Z, Tong B, Song Y, Wang K, Feng X, Lei J, Wang H, Zhang X, Ma L, Chen Y, Wei J, Ou Z, Peng S, Wu X, Tan L, Wang B, Yang C
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Chu X, Liu S, Qu B, Xin Y, Lu L
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Li F, Tian C, Wang Y, Wu H, Jin M, Du X, Yan J, Yang X, Yu H
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Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration.

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Translational research : the journal of laboratory and clinical medicine 2024 Oct;272:1-18

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Zhu J, Lin Y, Li G, He Y, Su Z, Tang Y, Zhang Y, Xu Q, Yao Z, Zhou H, Liu B, Cai X
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Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.

Qian B, Lu R, Mao S, Chen Y, Yang M, Zhang W, Zhang M, Zhu D, Liu Z, Zen K, Li L
Cell reports 2024 May 28;43(5):114249

Restoration of miR-299-3p promotes macrophage phagocytosis and suppresses malignant phenotypes in breast cancer carcinogenesis via dual-targeting CD47 and ABCE1.

Tong S, Zhu Y, Leng Y, Wu Y, Xiao X, Zhao W, Tan S
International immunopharmacology 2024 Mar 30;130:111708

Picroside II promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2(-/-) mice by polarizing M1 macrophages and balancing immune responses.

Jia K, Ma Z, Zhang Y, Xie K, Li J, Wu J, Qu J, Li F, Li X
Chinese journal of natural medicines 2024 Jul;22(7):582-598

ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia.

Lai J, Demirbas D, Kim J, Jeffries AM, Tolles A, Park J, Chittenden TW, Buckley PG, Yu TW, Lodato MA, Lee EA
Cell reports 2024 Jan 23;43(1):113622

Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.

Luan X, Lei T, Fang J, Liu X, Fu H, Li Y, Chu W, Jiang P, Tong C, Qi H, Fu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489

Hematopoietic Prostaglandin D Synthase Is Increased in Mast Cells and Pericytes in Autopsy Myocardial Specimens from Patients with Duchenne Muscular Dystrophy.

Hamamura K, Yoshida Y, Oyama K, Li J, Kawano S, Inoue K, Toyooka K, Yamadera M, Matsunaga N, Matsumura T, Aritake K
International journal of molecular sciences 2024 Feb 3;25(3)

Inflammatory dendritic cells restrain CD11b(+)CD4(+) CTLs via CD200R in human NSCLC.

Lin M, Chen D, Shao Z, Liu Q, Hao Z, Xin Z, Chen Y, Wu W, Chen X, He T, Wu D, Wu P
Cell reports 2024 Feb 27;43(2):113767

ITGAM-macrophage modulation as a potential strategy for treating neutrophilic Asthma: insights from bioinformatics analysis and in vivo experiments.

Yan Q, Liu Z, Chen Y, Zhang X, Zheng W, Liu X, Huang H, Liu Q, Jiang Y, Zhan S, Huang X
Apoptosis : an international journal on programmed cell death 2024 Apr;29(3-4):393-411

Investigating the role of itaconate in macrophage activation and oxidative stress injury in sepsis-associated acute kidney injury.

Yang L, Zhou P, Li R, Yin Y, Xie G, Shi L, Zhang P, Tao K
Molecular biology reports 2024 Apr 20;51(1):533

ITGAM is a critical gene in ischemic stroke.

Hou L, Li Z, Guo X, Lv J, Chong Z, Xiao Y, Zhang L, Li Z
Aging 2024 Apr 17;16(8):6852-6867

Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis.

Wu Q, Liang Z, Jiang J, Feng X, Liu J, Zhang Z, Wang H, Wang N, Gou Y, Li Z, Cao Y
Cell death & disease 2023 Oct 11;14(10):668

A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage.

Li LG, Yang XX, Xu HZ, Yu TT, Li QR, Hu J, Peng XC, Han N, Xu X, Chen NN, Chen X, Tang JM, Li TF
Advanced healthcare materials 2023 Nov;12(28):e2301561

The m6A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I-Mediated Immune Response.

Zhang L, Li Y, Zhou L, Zhou H, Ye L, Ou T, Hong H, Zheng S, Zhou Z, Wu K, Yan Z, Thiery JP, Cui J, Wu S
Cancer research 2023 Jun 2;83(11):1834-1850

Mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signaling is involved in phagocytosis activation during THP-1 cell differentiation.

Murokawa H, Egusa K, Shibutani S, Iwata H
The Journal of veterinary medical science 2023 Jul 17;85(7):772-780

Chlorin e6-induced photodynamic effect facilitates immunogenic cell death of lung cancer as a result of oxidative endoplasmic reticulum stress and DNA damage.

Yu TT, Hu J, Li QR, Peng XC, Xu HZ, Han N, Li LG, Yang XX, Xu X, Yang ZY, Chen H, Chen X, Wang MF, Li TF
International immunopharmacology 2023 Feb;115:109661

Effects of magnetically targeted iron oxide@polydopamine-labeled human umbilical cord mesenchymal stem cells in cerebral infarction in mice.

Yan J, Liu T, Li Y, Zhang J, Shi B, Zhang F, Hou X, Zhang X, Cui W, Li J, Yao H, Li X, Gao Y, Jiang J
Aging 2023 Feb 28;15(4):1130-1142

α5-nAChR/STAT3/CD47 axis contributed to nicotine-related lung adenocarcinoma progression and immune escape.

Kang G, Jiao Y, Pan P, Fan H, Li Q, Li X, Li J, Wang Y, Jia Y, Wang J, Sun H, Ma X
Carcinogenesis 2023 Dec 15;44(10-11):773-784

The CIS association of CD47 with integrin Mac-1 regulates macrophage responses by stabilizing the extended integrin conformation.

Podolnikova NP, Key S, Wang X, Ugarova TP
The Journal of biological chemistry 2023 Apr;299(4):103024

Activation of the High Mobility Group Box 1/Receptor for Advanced Glycation Endproducts /NOD-like Receptor Family Pyrin Domain-Containing 3 Axis Under Chronic Intermittent Hypoxia Induction Promotes the Progression of Atherosclerosis in ApoE(-/-) Mice.

Tan H, Hu J, Zuo W, Huang Y, Cui J, Gong F, Bai W
Journal of the American Heart Association 2023 Apr 18;12(8):e024397

Extracellular Vesicles of Mesenchymal Stem Cells Are More Effectively Accessed through Polyethylene Glycol-Based Precipitation than by Ultracentrifugation.

Jia L, Li B, Fang C, Liang X, Xie Y, Sun X, Wang W, Zheng L, Wang D
Stem cells international 2022;2022:3577015

Dihydroartemisinin remodels macrophage into an M1 phenotype via ferroptosis-mediated DNA damage.

Li LG, Peng XC, Yu TT, Xu HZ, Han N, Yang XX, Li QR, Hu J, Liu B, Yang ZY, Xu X, Chen X, Wang MF, Li TF
Frontiers in pharmacology 2022;13:949835

Transmembrane Protein 170B is a Prognostic Biomarker and Associated With Immune Infiltrates in Pancreatic Adenocarcinoma.

Zhang Z, Shang J, Dai Z, Yao Y, Shi Y, Zhong D, Liang Y, Lai C, Yang Q, Feng T, Huang X
Frontiers in genetics 2022;13:848391

AIM2 inflammasome activation benefits the therapeutic effect of BCG in bladder carcinoma.

Zhou H, Zhang L, Luo W, Hong H, Tang D, Zhou D, Zhou L, Li Y
Frontiers in pharmacology 2022;13:1050774

Combined bulk RNA-seq and single-cell RNA-seq identifies a necroptosis-related prognostic signature associated with inhibitory immune microenvironment in glioma.

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Frontiers in immunology 2022;13:1013094

Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages.

Gao T, Huang F, Wang W, Xie Y, Wang B
Cellular & molecular biology letters 2022 Mar 17;27(1):27

Photosynthetic microorganisms coupled photodynamic therapy for enhanced antitumor immune effect.

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Bioactive materials 2022 Jun;12:97-106

Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis.

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Cell death discovery 2022 Jul 4;8(1):305

Cox4i2 Triggers an Increase in Reactive Oxygen Species, Leading to Ferroptosis and Apoptosis in HHV7 Infected Schwann Cells.

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Frontiers in molecular biosciences 2021;8:660072

Neu-P11 - a novel melatonin receptor agonist, could improve the features of type-2 diabetes mellitus in rats.

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Endokrynologia Polska 2021;72(6):634-642

A novel mechanism of lung cancer inhibition by methionine enkephalin through remodeling the immune status of the tumor microenvironment.

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International immunopharmacology 2021 Oct;99:107999

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Asian journal of pharmaceutical sciences 2021 Jul;16(4):459-470

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Journal of neuroinflammation 2021 Jul 18;18(1):159

Redox Regulator GLRX Is Associated With Tumor Immunity in Glioma.

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Frontiers in immunology 2020;11:580934

Matrine Inhibits CNS Autoimmunity Through an IFN-β-Dependent Mechanism.

Chu YJ, Ma WD, Thome R, Ping JD, Liu FZ, Wang MR, Zhang ML, Zhang G, Zhu L
Frontiers in immunology 2020;11:569530

Dexmedetomidine ameliorates postoperative cognitive dysfunction by inhibiting Toll-like receptor 4 signaling in aged mice.

Zhou XY, Liu J, Xu ZP, Fu Q, Wang PQ, Wang JH, Zhang H
The Kaohsiung journal of medical sciences 2020 Sep;36(9):721-731

Anti-Alzheimer's disease activity of secondary metabolites from Xanthoceras sorbifolia Bunge.

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Food & function 2020 Mar 1;11(3):2067-2079

Reversal of Hypoxic Pulmonary Hypertension by Hypoxia-Inducible Overexpression of Angiotensin-(1-7) in Pulmonary Endothelial Cells.

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Molecular therapy. Methods & clinical development 2020 Jun 12;17:975-985

TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis.

Yan D, Wang J, Sun H, Zamani A, Zhang H, Chen W, Tang A, Ruan Q, Yang X, Chen YH, Wan X
The Journal of experimental medicine 2020 Feb 3;217(2)

The Extracellular Domain of the β(2) Integrin β Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity.

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Food & function 2019 Jul 17;10(7):3977-3991

Primary mouse brain pericytes isolated from transgenic Alzheimer mice spontaneously differentiate into a CD11b(+) microglial-like cell type in vitro.

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Experimental gerontology 2018 Oct 2;112:30-37

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