FNab01427

antibody from FineTest Biotech
Targeting: CD14
Provider product page for FNab01427
Western blot
ELISA

Antibody data

Product number
FNab01427 - Provider product page
Provider
FineTest Biotech
Product name
CD14 antibody
Antibody type
Monoclonal
Antigen
Recombinant protein fragment
Description
Coreceptor for bacterial lipopolysaccharide(PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide(LPS)(PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response(PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway(PubMed:16880211). Binds electronegative LDL(LDL(-)) and mediates the cytokine release induced by LDL(-)(PubMed:23880187).
Reactivity
Human, Mouse
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
CD14 molecule
Epitope
IgG1
Isotype
IgG
Antibody clone number
0G10
Vial size
100¦Ìg
Concentration
Protein A+G purification
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
CD14 protein structure - FNab01427 shown in red.