Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 301810 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#301810, RRID:AB_314192
- Product name
- LEAF™ Purified anti-human CD14 [M5E2]
- Antibody type
- Monoclonal
- Antigen
- CD14
- Description
- CD14 is a 53-55 kD glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein also known as LPS receptor. CD14 is expressed at high levels on monocytes and macrophages, and at lower levels on granulocytes. Some dendritic cell populations such as interfollicular dendritic cells, reticular dendritic cells, and Langerhans cells have also been reported to express CD14. As a high-affinity receptor for LPS, CD14 is involved in the clearance of gram-negative pathogens, and in the upregulation of adhesion molecules and expression of cytokines in monocytes and neutrophils.
- Reactivity
- Human, Bovine, Canine, Porcine, Sheep, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 500 µg
- Concentration
- 1 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
Submitted references C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes.
TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses.
Santer DM, Hall BE, George TC, Tangsombatvisit S, Liu CL, Arkwright PD, Elkon KB
Journal of immunology (Baltimore, Md. : 1950) 2010 Oct 15;185(8):4738-49
Journal of immunology (Baltimore, Md. : 1950) 2010 Oct 15;185(8):4738-49
TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses.
Iwamoto S, Iwai S, Tsujiyama K, Kurahashi C, Takeshita K, Naoe M, Masunaga A, Ogawa Y, Oguchi K, Miyazaki A
Journal of immunology (Baltimore, Md. : 1950) 2007 Aug 1;179(3):1449-57
Journal of immunology (Baltimore, Md. : 1950) 2007 Aug 1;179(3):1449-57
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Human peripheral blood monocytes stained with LEAF™ purified M5E2, followed by anti-mouse IgG FITC
- Conjugate
- Unconjugated