RA0067

antibody from Oursmab

Targeting: CD14

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0067

Provider

Oursmab

Product name

Atibuclimab (Biosimilar Reference Antibody) (CD14)

Antibody type

Monoclonal

Description

Atibuclimab (IC14) is a chimeric monoclonal antibody composed of murine variable regions and a human IgG4 Fc region. It functions as an antagonist targeting the CD14 glycoprotein. By binding to both membrane-bound (mCD14) and soluble (sCD14) forms of its target, Atibuclimab inhibits the signaling pathway initiated by microbial products like Lipopolysaccharide (LPS) (endotoxin). This blockade attenuates the resultant massive release of pro-inflammatory cytokines (e.g., TNFalpha, IL-6) that drive systemic inflammation. The IgG4 isotype is chosen to minimize complement activation and antibody-dependent cellular cytotoxicity. Atibuclimab has been extensively investigated as an anti-inflammatory therapeutic for conditions involving hyperinflammation and high levels of circulating bacterial products, such as sepsis, community-acquired pneumonia, and has also been studied for Amyotrophic Lateral Sclerosis (ALS) and Acute Respiratory Distress Syndrome (ARDS).

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Atibuclimab (Biosimilar Reference Antibody) (CD14)-RA0067 in a linear range of 3.91-500 ng/mL.