16-7338-85

antibody from Invitrogen Antibodies

Targeting: CSF3 C17orf33, G-CSF, GCSF, MGC45931

No application information provided.

Antibody Data

Product number

16-7338-85

Provider

Invitrogen Antibodies

Product name

G-CSF Monoclonal Antibody (4A4RC), Functional Grade, eBioscience™

Antibody type

Monoclonal

Antigen

Other

Description

Description: This 4A4RC monoclonal antibody reacts with G-CSF (Granulocyte Colony-Stimulating Factor), a growth factor that stimulates the proliferation, differentiation, and mobilization of hematopoetic stem cells. It is expressed by monocytes, macrophages, and bone marrow stromal cells, and can also be induced in fibroblasts by IL-17A. Unlike GM-CSF and IL-3, which can stimulate cells of multiple lineages, G-CSF activity is limited to neutrophilic granulocytes. G-CSF is essential to the maintenance of neutrophil counts during homeostasis, and low basal levels of the protein are detectable in the serum of healthy individuals. Circulating levels become elevated rapidly upon infection, as G-CSF is also important for the activation and mobilization of mature neutrophils during the innate immune response. G-CSF therapy is commonly used to treat neutropenia following bone marrow transplant or chemotherapy.

Antibody clone number

4A4RC

Concentration

1 mg/mL