BS4100

antibody from Bioworld Technology, Inc

Targeting: CHUK IkBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16

Immunohistochemistry

Antibody data

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Validation data

Product number: BS4100 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS4100, RRID:AB_1662754
Product name: IKKÏ« (phospho T23) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic phosphopeptide derived from human IKKÏ« around the phosphorylation site of Threonine 23.
Description: The NF-°ÙB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory I°ÙB proteins. Most agents that activate NF-°ÙB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of I°ÙB. The key regulatory step in this pathway involves activation of a high molecular weight I°ÙB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKÏ« and IKKÉÇ serve as the catalytic subunits of the kinase and IKKÎÛ serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKÉÇ (Ser176 and Ser180 in IKKÏ«), which causes conformational changes, resulting in kinase activation.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

CHUK protein structure - BS4100 shown in red.