orb67269

antibody from Biorbyt
Targeting: CHUK IkBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
Provider product page for orb67269
Western blot

Antibody data

Product number
orb67269 - Provider product page
Provider
Biorbyt
Product name
IKKA antibody
Antibody type
Polyclonal
Description
Rabbit polyclonal to IKKA.Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKKA) belongs to the protein kinasesuperfamily. IKKA is a serine kinase that plays an essential role in the NF-kappa-B signaling pathway,which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNAdamages or other cellular stresses. IKKA acts as part of the canonical IKK complex in theconventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B onserine residues. These modifications allow polyubiquitination of the inhibitors and subsequentdegradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus andactivates the transcription of hundreds of genes involved in immune response, growth control, orprotection against apoptosis. In addition, IKKA plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation.
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Vial size
100 ul
Storage
-20°C
CHUK protein structure - orb67269 shown in red.