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antibody from antibodies-online
Targeting: CHUK
IkBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
Western blot
Immunocytochemistry
Immunoprecipitation Immunohistochemistry Flow cytometry Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [73]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
- Flow cytometry [1]
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- Product number
- ABIN252647 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 14A231
- Vial size
- 0.1 mg
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Novel chemiluminescent Western blot blocking and antibody incubation solution for enhanced antibody-antigen interaction and increased specificity.
IKKα controls ATG16L1 degradation to prevent ER stress during inflammation.
Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.
Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.
IKKα-mediated biogenesis of miR-196a through interaction with Drosha regulates the sensitivity of cancer cells to radiotherapy.
MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB.
IKKα regulates the stratification and differentiation of the epidermis: implications for skin cancer development.
Deciphering the role of nuclear and cytoplasmic IKKα in skin cancer.
Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.
IKK kinase assay for assessment of canonical NF-κB activation in neurons.
Methods to assess the activation of the alternative (noncanonical) NF-κB pathway by non-death TNF receptors.
HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains.
Role of ferulic acid in the amelioration of ionizing radiation induced inflammation: a murine model.
Periderm prevents pathological epithelial adhesions during embryogenesis.
Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells.
Negative feedback regulation of NF-κB-inducing kinase is proteasome-dependent but does not require cellular inhibitors of apoptosis.
Noncanonical NF-κB signaling is limited by classical NF-κB activity.
Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells.
Curcumin inhibits tumor growth and angiogenesis in an orthotopic mouse model of human pancreatic cancer.
Opposing action of nuclear factor κB and Polo-like kinases determines a homeostatic end point for excitatory synaptic adaptation.
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.
NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.
TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.
Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells.
HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB.
Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin.
Opposing functions of IKKbeta during acute and chronic intestinal inflammation.
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.
Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma.
Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury.
Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch.
Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.
A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation.
Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury.
Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation.
An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells.
Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.
Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma.
I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.
Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts.
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation.
Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha.
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis.
Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death.
Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis.
Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis.
Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines.
The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion.
Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types.
Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.
Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
A recessive mutant cell line with a constitutive IkappaB kinase activity.
NEMO trimerizes through its coiled-coil C-terminal domain.
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester.
Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis.
Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation.
Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation.
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.
Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway.
Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis.
IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis.
Schwartz K, Bochkariov D
Electrophoresis 2017 Oct;38(20):2631-2637
Electrophoresis 2017 Oct;38(20):2631-2637
IKKα controls ATG16L1 degradation to prevent ER stress during inflammation.
Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR
The Journal of experimental medicine 2017 Feb;214(2):423-437
The Journal of experimental medicine 2017 Feb;214(2):423-437
Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.
Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M
Cancer cell 2017 Dec 11;32(6):824-839.e8
Cancer cell 2017 Dec 11;32(6):824-839.e8
Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.
Zhu F, Willette-Brown J, Song NY, Lomada D, Song Y, Xue L, Gray Z, Zhao Z, Davis SR, Sun Z, Zhang P, Wu X, Zhan Q, Richie ER, Hu Y
Cell host & microbe 2017 Apr 12;21(4):478-493.e7
Cell host & microbe 2017 Apr 12;21(4):478-493.e7
IKKα-mediated biogenesis of miR-196a through interaction with Drosha regulates the sensitivity of cancer cells to radiotherapy.
Fang X, Jeong JH, Long X, Park SJ, Wang D, Shuai M, Wei R, Li C, Li S, Zhang S, Duran MB, Lo KW, Tsao SW, Glaser R, Luo Z, Feng X, Tian Y, Luo JL
Cell death and differentiation 2016 Sep 1;23(9):1471-82
Cell death and differentiation 2016 Sep 1;23(9):1471-82
MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB.
Shintaku J, Peterson JM, Talbert EE, Gu JM, Ladner KJ, Williams DR, Mousavi K, Wang R, Sartorelli V, Guttridge DC
Cell reports 2016 Oct 4;17(2):514-526
Cell reports 2016 Oct 4;17(2):514-526
IKKα regulates the stratification and differentiation of the epidermis: implications for skin cancer development.
Alameda JP, Navarro M, Ramírez Á, Page A, Suárez-Cabrera C, Moreno-Maldonado R, Paramio JM, del Carmen Fariña MR, Del Río M, Fernández-Aceñero MJ, Bravo A, de Los Llanos Casanova MR
Oncotarget 2016 Nov 22;7(47):76779-76792
Oncotarget 2016 Nov 22;7(47):76779-76792
Deciphering the role of nuclear and cytoplasmic IKKα in skin cancer.
Alameda JP, Gaspar M, Ramírez Á, Navarro M, Page A, Suárez-Cabrera C, Fernández MG, Mérida JR, Paramio JM, García-Fernández RA, Fernández-Aceñero MJ, Casanova ML
Oncotarget 2016 May 17;7(20):29531-47
Oncotarget 2016 May 17;7(20):29531-47
Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.
Vincendeau M, Hadian K, Messias AC, Brenke JK, Halander J, Griesbach R, Greczmiel U, Bertossi A, Stehle R, Nagel D, Demski K, Velvarska H, Niessing D, Geerlof A, Sattler M, Krappmann D
Scientific reports 2016 Jan 7;6:18934
Scientific reports 2016 Jan 7;6:18934
IKK kinase assay for assessment of canonical NF-κB activation in neurons.
Mihalas AB, Meffert MK
Methods in molecular biology (Clifton, N.J.) 2015;1280:61-74
Methods in molecular biology (Clifton, N.J.) 2015;1280:61-74
Methods to assess the activation of the alternative (noncanonical) NF-κB pathway by non-death TNF receptors.
Remouchamps C, Dejardin E
Methods in molecular biology (Clifton, N.J.) 2015;1280:103-19
Methods in molecular biology (Clifton, N.J.) 2015;1280:103-19
HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains.
Ren T, Takahashi Y, Liu X, Loughran TP, Sun SC, Wang HG, Cheng H
Oncogene 2015 Jan 15;34(3):334-45
Oncogene 2015 Jan 15;34(3):334-45
Role of ferulic acid in the amelioration of ionizing radiation induced inflammation: a murine model.
Das U, Manna K, Sinha M, Datta S, Das DK, Chakraborty A, Ghosh M, Saha KD, Dey S
PloS one 2014;9(5):e97599
PloS one 2014;9(5):e97599
Periderm prevents pathological epithelial adhesions during embryogenesis.
Richardson RJ, Hammond NL, Coulombe PA, Saloranta C, Nousiainen HO, Salonen R, Berry A, Hanley N, Headon D, Karikoski R, Dixon MJ
The Journal of clinical investigation 2014 Sep;124(9):3891-900
The Journal of clinical investigation 2014 Sep;124(9):3891-900
Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells.
Pradhan N, Pratheek BM, Garai A, Kumar A, Meena VS, Ghosh S, Singh S, Kumari S, Chandrashekar TK, Goswami C, Chattopadhyay S, Kar S, Maiti PK
Cell biology international 2014 Oct;38(10):1118-31
Cell biology international 2014 Oct;38(10):1118-31
Negative feedback regulation of NF-κB-inducing kinase is proteasome-dependent but does not require cellular inhibitors of apoptosis.
Gray CM, McCorkell KA, Chunduru SK, McKinlay MA, May MJ
Biochemical and biophysical research communications 2014 Jul 18;450(1):341-6
Biochemical and biophysical research communications 2014 Jul 18;450(1):341-6
Noncanonical NF-κB signaling is limited by classical NF-κB activity.
Gray CM, Remouchamps C, McCorkell KA, Solt LA, Dejardin E, Orange JS, May MJ
Science signaling 2014 Feb 4;7(311):ra13
Science signaling 2014 Feb 4;7(311):ra13
Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells.
Buhrmann C, Busch F, Shayan P, Shakibaei M
The Journal of biological chemistry 2014 Aug 8;289(32):22048-62
The Journal of biological chemistry 2014 Aug 8;289(32):22048-62
Curcumin inhibits tumor growth and angiogenesis in an orthotopic mouse model of human pancreatic cancer.
Bimonte S, Barbieri A, Palma G, Luciano A, Rea D, Arra C
BioMed research international 2013;2013:810423
BioMed research international 2013;2013:810423
Opposing action of nuclear factor κB and Polo-like kinases determines a homeostatic end point for excitatory synaptic adaptation.
Mihalas AB, Araki Y, Huganir RL, Meffert MK
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Oct 16;33(42):16490-501
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Oct 16;33(42):16490-501
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.
Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, Greten FR
Cell 2013 Jan 17;152(1-2):25-38
Cell 2013 Jan 17;152(1-2):25-38
NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.
Cui J, Li Y, Zhu L, Liu D, Songyang Z, Wang HY, Wang RF
Nature immunology 2012 Mar 4;13(4):387-95
Nature immunology 2012 Mar 4;13(4):387-95
TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M
Proceedings of the National Academy of Sciences of the United States of America 2012 Jan 24;109(4):E177-86
Proceedings of the National Academy of Sciences of the United States of America 2012 Jan 24;109(4):E177-86
IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.
Bakkar N, Ladner K, Canan BD, Liyanarachchi S, Bal NC, Pant M, Periasamy M, Li Q, Janssen PM, Guttridge DC
The Journal of cell biology 2012 Feb 20;196(4):497-511
The Journal of cell biology 2012 Feb 20;196(4):497-511
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.
Phromnoi K, Reuter S, Sung B, Prasad S, Kannappan R, Yadav VR, Chanmahasathien W, Limtrakul P, Aggarwal BB
Molecular pharmacology 2011 Feb;79(2):279-89
Molecular pharmacology 2011 Feb;79(2):279-89
Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.
Harikumar KB, Sung B, Pandey MK, Guha S, Krishnan S, Aggarwal BB
Molecular pharmacology 2010 May;77(5):818-27
Molecular pharmacology 2010 May;77(5):818-27
Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells.
Hao L, Rizzo P, Osipo C, Pannuti A, Wyatt D, Cheung LW, Sonenshein G, Osborne BA, Miele L
Oncogene 2010 Jan 14;29(2):201-13
Oncogene 2010 Jan 14;29(2):201-13
HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB.
Huang J, Ren T, Guan H, Jiang Y, Cheng H
The Journal of biological chemistry 2009 Mar 6;284(10):6208-17
The Journal of biological chemistry 2009 Mar 6;284(10):6208-17
Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin.
Kasinski AL, Du Y, Thomas SL, Zhao J, Sun SY, Khuri FR, Wang CY, Shoji M, Sun A, Snyder JP, Liotta D, Fu H
Molecular pharmacology 2008 Sep;74(3):654-61
Molecular pharmacology 2008 Sep;74(3):654-61
Opposing functions of IKKbeta during acute and chronic intestinal inflammation.
Eckmann L, Nebelsiek T, Fingerle AA, Dann SM, Mages J, Lang R, Robine S, Kagnoff MF, Schmid RM, Karin M, Arkan MC, Greten FR
Proceedings of the National Academy of Sciences of the United States of America 2008 Sep 30;105(39):15058-63
Proceedings of the National Academy of Sciences of the United States of America 2008 Sep 30;105(39):15058-63
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis.
Kunnumakkara AB, Ichikawa H, Anand P, Mohankumar CJ, Hema PS, Nair MS, Aggarwal BB
Molecular cancer therapeutics 2008 Oct;7(10):3306-17
Molecular cancer therapeutics 2008 Oct;7(10):3306-17
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
Pandey MK, Sung B, Kunnumakkara AB, Sethi G, Chaturvedi MM, Aggarwal BB
Cancer research 2008 Jul 1;68(13):5370-9
Cancer research 2008 Jul 1;68(13):5370-9
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.
Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, Vignali DA, Bergsagel PL, Karin M
Nature immunology 2008 Dec;9(12):1364-70
Nature immunology 2008 Dec;9(12):1364-70
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.
Otipoby KL, Sasaki Y, Schmidt-Supprian M, Patke A, Gareus R, Pasparakis M, Tarakhovsky A, Rajewsky K
Proceedings of the National Academy of Sciences of the United States of America 2008 Aug 26;105(34):12435-8
Proceedings of the National Academy of Sciences of the United States of America 2008 Aug 26;105(34):12435-8
Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma.
Jackson-Bernitsas DG, Ichikawa H, Takada Y, Myers JN, Lin XL, Darnay BG, Chaturvedi MM, Aggarwal BB
Oncogene 2007 Mar 1;26(10):1385-97
Oncogene 2007 Mar 1;26(10):1385-97
Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury.
Beraza N, Lüdde T, Assmus U, Roskams T, Vander Borght S, Trautwein C
Gastroenterology 2007 Jun;132(7):2504-17
Gastroenterology 2007 Jun;132(7):2504-17
Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch.
Richardson RJ, Dixon J, Malhotra S, Hardman MJ, Knowles L, Boot-Handford RP, Shore P, Whitmarsh A, Dixon MJ
Nature genetics 2006 Nov;38(11):1329-34
Nature genetics 2006 Nov;38(11):1329-34
Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.
Vacca A, Felli MP, Palermo R, Di Mario G, Calce A, Di Giovine M, Frati L, Gulino A, Screpanti I
The EMBO journal 2006 Mar 8;25(5):1000-8
The EMBO journal 2006 Mar 8;25(5):1000-8
A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation.
Vinolo E, Sebban H, Chaffotte A, Israël A, Courtois G, Véron M, Agou F
The Journal of biological chemistry 2006 Mar 10;281(10):6334-48
The Journal of biological chemistry 2006 Mar 10;281(10):6334-48
Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury.
Chae S, Eckmann L, Miyamoto Y, Pothoulakis C, Karin M, Kagnoff MF
Journal of immunology (Baltimore, Md. : 1950) 2006 Jul 15;177(2):1214-20
Journal of immunology (Baltimore, Md. : 1950) 2006 Jul 15;177(2):1214-20
Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation.
Ichikawa H, Aggarwal BB
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Jan 15;12(2):662-8
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Jan 15;12(2):662-8
An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells.
Bürckstümmer T, Bennett KL, Preradovic A, Schütze G, Hantschel O, Superti-Furga G, Bauch A
Nature methods 2006 Dec;3(12):1013-9
Nature methods 2006 Dec;3(12):1013-9
Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.
Sethi G, Ahn KS, Sandur SK, Lin X, Chaturvedi MM, Aggarwal BB
The Journal of biological chemistry 2006 Aug 18;281(33):23425-35
The Journal of biological chemistry 2006 Aug 18;281(33):23425-35
Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma.
Shishodia S, Amin HM, Lai R, Aggarwal BB
Biochemical pharmacology 2005 Sep 1;70(5):700-13
Biochemical pharmacology 2005 Sep 1;70(5):700-13
I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.
Ruocco MG, Maeda S, Park JM, Lawrence T, Hsu LC, Cao Y, Schett G, Wagner EF, Karin M
The Journal of experimental medicine 2005 May 16;201(10):1677-87
The Journal of experimental medicine 2005 May 16;201(10):1677-87
Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts.
Nonaka M, Horie R, Itoh K, Watanabe T, Yamamoto N, Yamaoka S
Oncogene 2005 Jun 2;24(24):3976-86
Oncogene 2005 Jun 2;24(24):3976-86
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Ichikawa H, Takada Y, Murakami A, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2005 Jun 1;174(11):7383-92
Journal of immunology (Baltimore, Md. : 1950) 2005 Jun 1;174(11):7383-92
Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation.
Panopoulos A, Harraz M, Engelhardt JF, Zandi E
The Journal of biological chemistry 2005 Jan 28;280(4):2912-23
The Journal of biological chemistry 2005 Jan 28;280(4):2912-23
Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha.
Nishio M, Endo T, Tsukada N, Ohata J, Kitada S, Reed JC, Zvaifler NJ, Kipps TJ
Blood 2005 Aug 1;106(3):1012-20
Blood 2005 Aug 1;106(3):1012-20
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
Takada Y, Fang X, Jamaluddin MS, Boyd DD, Aggarwal BB
The Journal of biological chemistry 2004 Sep 17;279(38):39541-54
The Journal of biological chemistry 2004 Sep 17;279(38):39541-54
Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis.
Shishodia S, Aggarwal BB
The Journal of biological chemistry 2004 Nov 5;279(45):47148-58
The Journal of biological chemistry 2004 Nov 5;279(45):47148-58
Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death.
Chandrasekar B, Vemula K, Surabhi RM, Li-Weber M, Owen-Schaub LB, Jensen LE, Mummidi S
The Journal of biological chemistry 2004 May 7;279(19):20221-33
The Journal of biological chemistry 2004 May 7;279(19):20221-33
Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.
Takada Y, Aggarwal BB
The Journal of biological chemistry 2004 Feb 6;279(6):4750-9
The Journal of biological chemistry 2004 Feb 6;279(6):4750-9
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis.
Shishodia S, Koul D, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2004 Aug 1;173(3):2011-22
Journal of immunology (Baltimore, Md. : 1950) 2004 Aug 1;173(3):2011-22
Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis.
Takada Y, Singh S, Aggarwal BB
The Journal of biological chemistry 2004 Apr 9;279(15):15096-104
The Journal of biological chemistry 2004 Apr 9;279(15):15096-104
Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines.
Saito N, Courtois G, Chiba A, Yamamoto N, Nitta T, Hironaka N, Rowe M, Yamamoto N, Yamaoka S
The Journal of biological chemistry 2003 Nov 21;278(47):46565-75
The Journal of biological chemistry 2003 Nov 21;278(47):46565-75
The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion.
Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M
Nature medicine 2003 May;9(5):575-81
Nature medicine 2003 May;9(5):575-81
Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types.
Majumdar S, Aggarwal BB
Oncogene 2003 Feb 27;22(8):1206-18
Oncogene 2003 Feb 27;22(8):1206-18
Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.
Shishodia S, Majumdar S, Banerjee S, Aggarwal BB
Cancer research 2003 Aug 1;63(15):4375-83
Cancer research 2003 Aug 1;63(15):4375-83
Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.
Anto RJ, Mukhopadhyay A, Shishodia S, Gairola CG, Aggarwal BB
Carcinogenesis 2002 Sep;23(9):1511-8
Carcinogenesis 2002 Sep;23(9):1511-8
The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.
Makris C, Roberts JL, Karin M
Molecular and cellular biology 2002 Sep;22(18):6573-81
Molecular and cellular biology 2002 Sep;22(18):6573-81
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
Dejardin E, Droin NM, Delhase M, Haas E, Cao Y, Makris C, Li ZW, Karin M, Ware CF, Green DR
Immunity 2002 Oct;17(4):525-35
Immunity 2002 Oct;17(4):525-35
A recessive mutant cell line with a constitutive IkappaB kinase activity.
Chinanonwait N, Miura H, Yamamoto N, Yamaoka S
FEBS letters 2002 Nov 20;531(3):553-60
FEBS letters 2002 Nov 20;531(3):553-60
NEMO trimerizes through its coiled-coil C-terminal domain.
Agou F, Ye F, Goffinont S, Courtois G, Yamaoka S, Israël A, Véron M
The Journal of biological chemistry 2002 May 17;277(20):17464-75
The Journal of biological chemistry 2002 May 17;277(20):17464-75
Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester.
Majumdar S, Lamothe B, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2002 Mar 15;168(6):2644-51
Journal of immunology (Baltimore, Md. : 1950) 2002 Mar 15;168(6):2644-51
Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis.
Greten FR, Weber CK, Greten TF, Schneider G, Wagner M, Adler G, Schmid RM
Gastroenterology 2002 Dec;123(6):2052-63
Gastroenterology 2002 Dec;123(6):2052-63
Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation.
Ashikawa K, Majumdar S, Banerjee S, Bharti AC, Shishodia S, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2002 Dec 1;169(11):6490-7
Journal of immunology (Baltimore, Md. : 1950) 2002 Dec 1;169(11):6490-7
Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation.
Miller BS, Zandi E
The Journal of biological chemistry 2001 Sep 28;276(39):36320-6
The Journal of biological chemistry 2001 Sep 28;276(39):36320-6
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.
Majumdar S, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2001 Sep 1;167(5):2911-20
Journal of immunology (Baltimore, Md. : 1950) 2001 Sep 1;167(5):2911-20
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.
Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M
Cell 2001 Dec 14;107(6):763-75
Cell 2001 Dec 14;107(6):763-75
Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway.
Koul D, Yao Y, Abbruzzese JL, Yung WK, Reddy SA
The Journal of biological chemistry 2001 Apr 6;276(14):11402-8
The Journal of biological chemistry 2001 Apr 6;276(14):11402-8
Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis.
Manna SK, Mukhopadhyay A, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 15;165(10):5962-9
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 15;165(10):5962-9
IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis.
Manna SK, Mukhopadhyay A, Aggarwal BB
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 1;165(9):4927-34
Journal of immunology (Baltimore, Md. : 1950) 2000 Nov 1;165(9):4927-34
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Supportive validation
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