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Other assayAntibody data
- Antibody Data
- Antigen structure
- References [2]
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- Other assay [1]
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- Product number
- 16-5236-85 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- IL-23 p19 Monoclonal Antibody (HNU2319), Functional Grade, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The HNU2319 monoclonal antibody is specific to the p19 subunit of human IL-23, a heterodimeric cytokine made up of two covalently linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. Dendritic cells and macrophages produce IL-23 in response to TLR2, TLR4, and TLR8 ligands, as well as the beta-glucan receptor Dectin-1.
- Antibody clone number
- HNU2319
- Concentration
- 1 mg/mL
Submitted references Periodontitis-associated pathogens P. gingivalis and A. actinomycetemcomitans activate human CD14(+) monocytes leading to enhanced Th17/IL-17 responses.
Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways.
Cheng WC, van Asten SD, Burns LA, Evans HG, Walter GJ, Hashim A, Hughes FJ, Taams LS
European journal of immunology 2016 Sep;46(9):2211-21
European journal of immunology 2016 Sep;46(9):2211-21
Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways.
Dennehy KM, Willment JA, Williams DL, Brown GD
European journal of immunology 2009 May;39(5):1379-86
European journal of immunology 2009 May;39(5):1379-86
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Neutralization of Human IL-23 Recombinant Protein activity as measured by IL-17A induction in BALB/c splenocytes.
