CABT-B9369

antibody from Creative Diagnostics

Targeting: JUP CTNNG, DP3, DPIII, PDGB, PKGB

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-B9369

Provider

Creative Diagnostics

Product name

Mouse anti-Human ÎÛ-Catenin monoclonal antibody, clone 26

Antibody type

Monoclonal

Description

ÎÛ-Catenin (plakoglobin) was identified as a compenent of desmosomes where it associates with desmoglein. ÎÛ-Catenin and ÉÇ-Catenin are closely related proteins that have significant homology with the Drosophila armadillo protein. In addition to complexing with E-Cadherin, ÎÛ-Catenin and ÉÇ-Catenin have been observed in association with the intracellular domain of N-Cadherin. It has been proposed that one molecule of Ï«-Catenin and at least one molecule of ÉÇ-Catenin and ÎÛ-Catenin simultaneously bind to a single cadherin molecule. A 19 amino acid sequence of desmoglein (Dsg1) was found to be critical for binding of ÎÛ-Catenin. This region has significant homology to the catenin-binding domain of classical cadherins, thus suggesting a common mechanism for ÎÛ-Catenin localization at both adherens junctions and desmosomes.

Reactivity

Human, Mouse, Rat, Canine, Chicken/Avian

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

26

Vial size

50ug, 150ug

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.