Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- CABT-B9369 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Mouse anti-Human ÎÛ-Catenin monoclonal antibody, clone 26
- Antibody type
- Monoclonal
- Description
- ÎÛ-Catenin (plakoglobin) was identified as a compenent of desmosomes where it associates with desmoglein. ÎÛ-Catenin and ÉÇ-Catenin are closely related proteins that have significant homology with the Drosophila armadillo protein. In addition to complexing with E-Cadherin, ÎÛ-Catenin and ÉÇ-Catenin have been observed in association with the intracellular domain of N-Cadherin. It has been proposed that one molecule of Ï«-Catenin and at least one molecule of ÉÇ-Catenin and ÎÛ-Catenin simultaneously bind to a single cadherin molecule. A 19 amino acid sequence of desmoglein (Dsg1) was found to be critical for binding of ÎÛ-Catenin. This region has significant homology to the catenin-binding domain of classical cadherins, thus suggesting a common mechanism for ÎÛ-Catenin localization at both adherens junctions and desmosomes.
- Reactivity
- Human, Mouse, Rat, Canine, Chicken/Avian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 26
- Vial size
- 50ug, 150ug
- Concentration
- 250 Ã×g/ml
- Storage
- Store undiluted at -20°C.
No comments: Submit comment
No validations: Submit validation data