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antibody from Invitrogen Antibodies
Targeting: CD44
CD44R, CSPG8, HCELL, IN, MC56, MDU2, MDU3, MIC4, Pgp1
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [78]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 13-0441-81 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Anti-CD44 Monoclonal Antibody (IM7), Biotin, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The IM7 monoclonal antibody reacts with all isoforms of mouse CD44 (Pgp-1). CD44 is expressed by hematopoietic and non-hematopoietic cells. Bone marrow myeloid cells and memory T cells highly express this antigen and peripheral B and T cells can upregulate the expression of CD44. CD44 functions as an adhesion molecule through its binding to hyaluronate, an extracellular matrix component. Applications Reported: The IM7 antibody has been reported for use in flow cytometric analysis. Applications Tested: The IM7 antibody has been tested by flow cytometric analysis of mouse bone marrow cells and splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 µm post-manufacturing filtered.
- Reactivity
- Human, Mouse
- Host
- Rat
- Conjugate
- Biotin
- Isotype
- IgG
- Antibody clone number
- IM7
- Vial size
- 50 µg
- Concentration
- 0.5 mg/mL
- Storage
- 4° C, store in dark, DO NOT FREEZE!
Submitted references TGF‑β induces periodontal ligament stem cell senescence through increase of ROS production.
The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.
Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair.
Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNA‑Meg3/miR‑421/PDGFRA axis.
Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.
Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.
Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin.
Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.
An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer.
Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43.
Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling.
Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8+ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis.
Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells.
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.
Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.
The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.
Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells.
Comparison of Four Protocols to Generate Chondrocyte-Like Cells from Human Induced Pluripotent Stem Cells (hiPSCs).
Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.
Comparable roles of CD44v8-10 and CD44s in the development of bone metastases in a mouse model.
Sertoli cell condition medium can induce germ like cells from bone marrow derived mesenchymal stem cells.
SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.
Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer.
PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.
Cryptotanshinone targets tumor-initiating cells through down-regulation of stemness genes expression.
Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.
The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states.
Oligodendrocyte death results in immune-mediated CNS demyelination.
Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro.
Equine-Induced Pluripotent Stem Cells Retain Lineage Commitment Toward Myogenic and Chondrogenic Fates.
Breast cancer stem cells expressing different stem cell markers exhibit distinct biological characteristics.
A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production.
Multi-lineage differentiation of human umbilical cord Wharton's Jelly Mesenchymal Stromal Cells mediates changes in the expression profile of stemness markers.
Reprogramming Roadblocks Are System Dependent.
Anisotropic stress orients remodelling of mammalian limb bud ectoderm.
Special AT-rich sequence-binding protein-1 participates in the maintenance of breast cancer stem cells through regulation of the Notch signaling pathway and expression of Snail1 and Twist1.
Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model.
Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.
Enrichment of Human Stem-Like Prostate Cells with s-SHIP Promoter Activity Uncovers a Role in Stemness for the Long Noncoding RNA H19.
Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation.
Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.
Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.
FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells.
Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties.
Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation.
Serum- and growth-factor-free three-dimensional culture system supports cartilage tissue formation by promoting collagen synthesis via Sox9-Col2a1 interaction.
Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo.
Evidence for a multipotent mammary progenitor with pregnancy-specific activity.
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
Increased invasion and tumorigenicity capacity of CD44+/CD24- breast cancer MCF7 cells in vitro and in nude mice.
High-resolution analysis with novel cell-surface markers identifies routes to iPS cells.
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf.
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.
Distinct fibroblast lineages determine dermal architecture in skin development and repair.
Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division.
Estrogen and progesterone together expand murine endometrial epithelial progenitor cells.
The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability.
Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease.
Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation.
Increased protection from vaccinia virus infection in mice genetically prone to lymphoproliferative disorders.
Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells.
The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.
GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state.
High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event.
PTEN loss accelerates KrasG12D-induced pancreatic cancer development.
CD44 expression is developmentally regulated in the mouse lens and increases in the lens epithelium after injury.
Two host factors regulate persistence of H7-specific T cells injected in tumor-bearing mice.
Effects of Culturing on the Stability of the Putative Murine Adipose Derived Stem Cells Markers.
Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection.
Fan C, Ji Q, Zhang C, Xu S, Sun H, Li Z
Molecular medicine reports 2019 Oct;20(4):3123-3130
Molecular medicine reports 2019 Oct;20(4):3123-3130
The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.
Tuladhar S, Kochanowsky JA, Bhaskara A, Ghotmi Y, Chandrasekaran S, Koshy AA
PLoS pathogens 2019 Oct;15(10):e1007856
PLoS pathogens 2019 Oct;15(10):e1007856
Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair.
Colunga T, Hayworth M, Kreß S, Reynolds DM, Chen L, Nazor KL, Baur J, Singh AM, Loring JF, Metzger M, Dalton S
Cell reports 2019 Mar 5;26(10):2566-2579.e10
Cell reports 2019 Mar 5;26(10):2566-2579.e10
Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNA‑Meg3/miR‑421/PDGFRA axis.
Ye W, Ni Z, Yicheng S, Pan H, Huang Y, Xiong Y, Liu T
International journal of oncology 2019 Dec;55(6):1296-1312
International journal of oncology 2019 Dec;55(6):1296-1312
Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.
Alriyami M, Marchand L, Li Q, Du X, Olivier M, Polychronakos C
Genome research 2019 Dec;29(12):1951-1961
Genome research 2019 Dec;29(12):1951-1961
Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.
Liu Z, Ge Y, Wang H, Ma C, Feist M, Ju S, Guo ZS, Bartlett DL
Nature communications 2018 Nov 8;9(1):4682
Nature communications 2018 Nov 8;9(1):4682
Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin.
Huang W, Bei L, Eklund EA
Oncotarget 2018 May 25;9(40):25891-25902
Oncotarget 2018 May 25;9(40):25891-25902
Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.
Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G, Song J, Wang J, Wei H, Zhang J, Sun R, Zhang C, Tian Z
Nature communications 2018 Mar 28;9(1):1241
Nature communications 2018 Mar 28;9(1):1241
An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer.
Li J, Choi PS, Chaffer CL, Labella K, Hwang JH, Giacomelli AO, Kim JW, Ilic N, Doench JG, Ly SH, Dai C, Hagel K, Hong AL, Gjoerup O, Goel S, Ge JY, Root DE, Zhao JJ, Brooks AN, Weinberg RA, Hahn WC
eLife 2018 Jul 30;7
eLife 2018 Jul 30;7
Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43.
Li Z, Zhang S, Cao L, Li W, Ye YC, Shi ZX, Wang ZR, Sun LX, Wang JW, Jia LT, Wang W
Experimental and therapeutic medicine 2018 Feb;15(2):1847-1854
Experimental and therapeutic medicine 2018 Feb;15(2):1847-1854
Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling.
Cao Y, Lin SH, Wang Y, Chin YE, Kang L, Mi J
Theranostics 2017;7(12):3021-3033
Theranostics 2017;7(12):3021-3033
Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.
Gao SY, Zheng GS, Wang L, Liang YJ, Zhang SE, Lao XM, Li K, Liao GQ
PloS one 2017;12(6):e0179248
PloS one 2017;12(6):e0179248
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Alzubi J, Pallant C, Mussolino C, Howe SJ, Thrasher AJ, Cathomen T
Scientific reports 2017 Sep 29;7(1):12475
Scientific reports 2017 Sep 29;7(1):12475
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Deng R, Hurtz C, Song Q, Yue C, Xiao G, Yu H, Wu X, Muschen M, Forman S, Martin PJ, Zeng D
Nature communications 2017 Oct 17;8(1):978
Nature communications 2017 Oct 17;8(1):978
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Wang Q, Ning H, Peng H, Wei L, Hou R, Hoft DF, Liu J
Nature communications 2017 Oct 11;8(1):867
Nature communications 2017 Oct 11;8(1):867
Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8+ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis.
Cui N, Wang H, Su LX, Zhang JH, Long Y, Liu DW
Chinese medical journal 2017 May 20;130(10):1211-1217
Chinese medical journal 2017 May 20;130(10):1211-1217
Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells.
Bierie B, Pierce SE, Kroeger C, Stover DG, Pattabiraman DR, Thiru P, Liu Donaher J, Reinhardt F, Chaffer CL, Keckesova Z, Weinberg RA
Proceedings of the National Academy of Sciences of the United States of America 2017 Mar 21;114(12):E2337-E2346
Proceedings of the National Academy of Sciences of the United States of America 2017 Mar 21;114(12):E2337-E2346
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
Miao T, Symonds ALJ, Singh R, Symonds JD, Ogbe A, Omodho B, Zhu B, Li S, Wang P
The Journal of experimental medicine 2017 Jun 5;214(6):1787-1808
The Journal of experimental medicine 2017 Jun 5;214(6):1787-1808
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
Cruz LO, Hashemifar SS, Wu CJ, Cho S, Nguyen DT, Lin LL, Khan AA, Lu LF
The Journal of clinical investigation 2017 Feb 1;127(2):530-542
The Journal of clinical investigation 2017 Feb 1;127(2):530-542
Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.
Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian TV, Kaemena DF, Tosti L, Tan W, Manning JR, Chantzoura E, Ottosson DR, Collombet S, Johnsson A, Cohen E, Yusa K, Linnarsson S, Graf T, Parmar M, Kaji K
Cell stem cell 2017 Dec 7;21(6):791-805.e9
Cell stem cell 2017 Dec 7;21(6):791-805.e9
Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.
Turaj AH, Hussain K, Cox KL, Rose-Zerilli MJJ, Testa J, Dahal LN, Chan HTC, James S, Field VL, Carter MJ, Kim HJ, West JJ, Thomas LJ, He LZ, Keler T, Johnson PWM, Al-Shamkhani A, Thirdborough SM, Beers SA, Cragg MS, Glennie MJ, Lim SH
Cancer cell 2017 Dec 11;32(6):777-791.e6
Cancer cell 2017 Dec 11;32(6):777-791.e6
The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.
Sitrin J, Suto E, Wuster A, Eastham-Anderson J, Kim JM, Austin CD, Lee WP, Behrens TW
Journal of immunology (Baltimore, Md. : 1950) 2017 Aug 15;199(4):1238-1249
Journal of immunology (Baltimore, Md. : 1950) 2017 Aug 15;199(4):1238-1249
Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells.
Liao CP, Chen LY, Luethy A, Kim Y, Kani K, MacLeod AR, Gross ME
Endocrine-related cancer 2017 Apr;24(4):157-170
Endocrine-related cancer 2017 Apr;24(4):157-170
Comparison of Four Protocols to Generate Chondrocyte-Like Cells from Human Induced Pluripotent Stem Cells (hiPSCs).
Suchorska WM, Augustyniak E, Richter M, Trzeciak T
Stem cell reviews and reports 2017 Apr;13(2):299-308
Stem cell reviews and reports 2017 Apr;13(2):299-308
Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.
Greenwood E, Maisel S, Ebertz D, Russ A, Pandey R, Schroeder J
Oncotarget 2016 Sep 20;7(38):60776-60792
Oncotarget 2016 Sep 20;7(38):60776-60792
Comparable roles of CD44v8-10 and CD44s in the development of bone metastases in a mouse model.
Hiraga T, Nakamura H
Oncology letters 2016 Oct;12(4):2962-2969
Oncology letters 2016 Oct;12(4):2962-2969
Sertoli cell condition medium can induce germ like cells from bone marrow derived mesenchymal stem cells.
Monfared MH, Minaee B, Rastegar T, Khrazinejad E, Barbarestani M
Iranian journal of basic medical sciences 2016 Nov;19(11):1186-1192
Iranian journal of basic medical sciences 2016 Nov;19(11):1186-1192
SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.
Kim BR, Van de Laar E, Cabanero M, Tarumi S, Hasenoeder S, Wang D, Virtanen C, Suzuki T, Bandarchi B, Sakashita S, Pham NA, Lee S, Keshavjee S, Waddell TK, Tsao MS, Moghal N
PLoS biology 2016 Nov;14(11):e1002581
PLoS biology 2016 Nov;14(11):e1002581
Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer.
Park JW, Park JM, Park DM, Kim DY, Kim HK
Stem cells (Dayton, Ohio) 2016 May;34(5):1177-87
Stem cells (Dayton, Ohio) 2016 May;34(5):1177-87
PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.
Carofino BL, Ayanga B, Tracey LJ, Brooke-Bisschop T, Justice MJ
Biology open 2016 May 15;5(5):645-53
Biology open 2016 May 15;5(5):645-53
Cryptotanshinone targets tumor-initiating cells through down-regulation of stemness genes expression.
Zhang Y, Cabarcas SM, Zheng JI, Sun L, Mathews LA, Zhang X, Lin H, Farrar WL
Oncology letters 2016 Jun;11(6):3803-3812
Oncology letters 2016 Jun;11(6):3803-3812
Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.
Brinkman CC, Iwami D, Hritzo MK, Xiong Y, Ahmad S, Simon T, Hippen KL, Blazar BR, Bromberg JS
Nature communications 2016 Jun 21;7:12021
Nature communications 2016 Jun 21;7:12021
The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states.
Toneff MJ, Sreekumar A, Tinnirello A, Hollander PD, Habib S, Li S, Ellis MJ, Xin L, Mani SA, Rosen JM
BMC biology 2016 Jun 17;14:47
BMC biology 2016 Jun 17;14:47
Oligodendrocyte death results in immune-mediated CNS demyelination.
Traka M, Podojil JR, McCarthy DP, Miller SD, Popko B
Nature neuroscience 2016 Jan;19(1):65-74
Nature neuroscience 2016 Jan;19(1):65-74
Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro.
Hu Y, Zhang Y, Tian K, Xun C, Wang S, Lv D
Molecular medicine reports 2016 Jan;13(1):49-58
Molecular medicine reports 2016 Jan;13(1):49-58
Equine-Induced Pluripotent Stem Cells Retain Lineage Commitment Toward Myogenic and Chondrogenic Fates.
Quattrocelli M, Giacomazzi G, Broeckx SY, Ceelen L, Bolca S, Spaas JH, Sampaolesi M
Stem cell reports 2016 Jan 12;6(1):55-63
Stem cell reports 2016 Jan 12;6(1):55-63
Breast cancer stem cells expressing different stem cell markers exhibit distinct biological characteristics.
Shao J, Fan W, Ma B, Wu Y
Molecular medicine reports 2016 Dec;14(6):4991-4998
Molecular medicine reports 2016 Dec;14(6):4991-4998
A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Jeric I, Maurer G, Cavallo AL, Raguz J, Desideri E, Tarkowski B, Parrini M, Fischer I, Zatloukal K, Baccarini M
Nature communications 2016 Dec 21;7:13781
Nature communications 2016 Dec 21;7:13781
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Menendez CM, Jinkins JK, Carr DJ
Journal of immunology (Baltimore, Md. : 1950) 2016 Aug 15;197(4):1262-75
Journal of immunology (Baltimore, Md. : 1950) 2016 Aug 15;197(4):1262-75
Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production.
Camilleri ET, Gustafson MP, Dudakovic A, Riester SM, Garces CG, Paradise CR, Takai H, Karperien M, Cool S, Sampen HJ, Larson AN, Qu W, Smith J, Dietz AB, van Wijnen AJ
Stem cell research & therapy 2016 Aug 11;7(1):107
Stem cell research & therapy 2016 Aug 11;7(1):107
Multi-lineage differentiation of human umbilical cord Wharton's Jelly Mesenchymal Stromal Cells mediates changes in the expression profile of stemness markers.
Ali H, Al-Yatama MK, Abu-Farha M, Behbehani K, Al Madhoun A
PloS one 2015;10(4):e0122465
PloS one 2015;10(4):e0122465
Reprogramming Roadblocks Are System Dependent.
Chantzoura E, Skylaki S, Menendez S, Kim SI, Johnsson A, Linnarsson S, Woltjen K, Chambers I, Kaji K
Stem cell reports 2015 Sep 8;5(3):350-64
Stem cell reports 2015 Sep 8;5(3):350-64
Anisotropic stress orients remodelling of mammalian limb bud ectoderm.
Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JT, Wong MD, Li D, Deimling S, Ciruna B, Scott I, Simmons C, Henkelman RM, Williams T, Hadjantonakis AK, Fernandez-Gonzalez R, Sun Y, Hopyan S
Nature cell biology 2015 May;17(5):569-79
Nature cell biology 2015 May;17(5):569-79
Special AT-rich sequence-binding protein-1 participates in the maintenance of breast cancer stem cells through regulation of the Notch signaling pathway and expression of Snail1 and Twist1.
Sun Z, Zhang C, Zou X, Jiang G, Xu Z, Li W, Xie H
Molecular medicine reports 2015 May;11(5):3235-542
Molecular medicine reports 2015 May;11(5):3235-542
Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model.
Zhou F, Gao S, Wang L, Sun C, Chen L, Yuan P, Zhao H, Yi Y, Qin Y, Dong Z, Cao L, Ren H, Zhu L, Li Q, Lu B, Liang A, Xu GT, Zhu H, Gao Z, Ma J, Xu J, Chen X
Stem cell research & therapy 2015 May 9;6:92
Stem cell research & therapy 2015 May 9;6:92
Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.
Zhang S, Chung WC, Wu G, Egan SE, Miele L, Xu K
Cancer research 2015 May 15;75(10):1936-43
Cancer research 2015 May 15;75(10):1936-43
Enrichment of Human Stem-Like Prostate Cells with s-SHIP Promoter Activity Uncovers a Role in Stemness for the Long Noncoding RNA H19.
Bauderlique-Le Roy H, Vennin C, Brocqueville G, Spruyt N, Adriaenssens E, Bourette RP
Stem cells and development 2015 May 15;24(10):1252-62
Stem cells and development 2015 May 15;24(10):1252-62
Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation.
Samant MD, Jackson CM, Felix CL, Jones AJ, Goodrich DW, Foster BA, Huss WJ
Stem cells and development 2015 May 15;24(10):1236-51
Stem cells and development 2015 May 15;24(10):1236-51
Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.
Quattrocelli M, Swinnen M, Giacomazzi G, Camps J, Barthélemy I, Ceccarelli G, Caluwé E, Grosemans H, Thorrez L, Pelizzo G, Muijtjens M, Verfaillie CM, Blot S, Janssens S, Sampaolesi M
The Journal of clinical investigation 2015 Dec;125(12):4463-82
The Journal of clinical investigation 2015 Dec;125(12):4463-82
Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.
Xiao GY, Liu IH, Cheng CC, Chang CC, Lee YH, Cheng WT, Wu SC
PloS one 2014;9(9):e106538
PloS one 2014;9(9):e106538
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.
Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming JB, Cantley LC, DePinho RA, Draetta GF
Nature 2014 Oct 30;514(7524):628-32
Nature 2014 Oct 30;514(7524):628-32
FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells.
Wei HJ, Nickoloff JA, Chen WH, Liu HY, Lo WC, Chang YT, Yang PC, Wu CW, Williams DF, Gelovani JG, Deng WP
Oncotarget 2014 Oct 15;5(19):9514-29
Oncotarget 2014 Oct 15;5(19):9514-29
Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties.
Wu TH, Chou YW, Chiu PH, Tang MJ, Hu CW, Yeh ML
Cancer cell international 2014 Mar 3;14(1):20
Cancer cell international 2014 Mar 3;14(1):20
Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation.
Zhang S, Chung WC, Wu G, Egan SE, Xu K
Neoplasia (New York, N.Y.) 2014 Feb;16(2):158-67
Neoplasia (New York, N.Y.) 2014 Feb;16(2):158-67
Serum- and growth-factor-free three-dimensional culture system supports cartilage tissue formation by promoting collagen synthesis via Sox9-Col2a1 interaction.
Ahmed N, Iu J, Brown CE, Taylor DW, Kandel RA
Tissue engineering. Part A 2014 Aug;20(15-16):2224-33
Tissue engineering. Part A 2014 Aug;20(15-16):2224-33
Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo.
Wu S, Ju GQ, Du T, Zhu YJ, Liu GH
PloS one 2013;8(4):e61366
PloS one 2013;8(4):e61366
Evidence for a multipotent mammary progenitor with pregnancy-specific activity.
Kaanta AS, Virtanen C, Selfors LM, Brugge JS, Neel BG
Breast cancer research : BCR 2013;15(4):R65
Breast cancer research : BCR 2013;15(4):R65
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
Zhang Y, Yang P, Sun T, Li D, Xu X, Rui Y, Li C, Chong M, Ibrahim T, Mercatali L, Amadori D, Lu X, Xie D, Li QJ, Wang XF
Nature cell biology 2013 Mar;15(3):284-94
Nature cell biology 2013 Mar;15(3):284-94
Increased invasion and tumorigenicity capacity of CD44+/CD24- breast cancer MCF7 cells in vitro and in nude mice.
Yan W, Chen Y, Yao Y, Zhang H, Wang T
Cancer cell international 2013 Jun 24;13(1):62
Cancer cell international 2013 Jun 24;13(1):62
High-resolution analysis with novel cell-surface markers identifies routes to iPS cells.
O'Malley J, Skylaki S, Iwabuchi KA, Chantzoura E, Ruetz T, Johnsson A, Tomlinson SR, Linnarsson S, Kaji K
Nature 2013 Jul 4;499(7456):88-91
Nature 2013 Jul 4;499(7456):88-91
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf.
Baumgartner F, Woess C, Pedit V, Tzankov A, Labi V, Villunger A
Oncogene 2013 Jan 31;32(5):621-30
Oncogene 2013 Jan 31;32(5):621-30
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.
Chou J, Lin JH, Brenot A, Kim JW, Provot S, Werb Z
Nature cell biology 2013 Feb;15(2):201-13
Nature cell biology 2013 Feb;15(2):201-13
Distinct fibroblast lineages determine dermal architecture in skin development and repair.
Driskell RR, Lichtenberger BM, Hoste E, Kretzschmar K, Simons BD, Charalambous M, Ferron SR, Herault Y, Pavlovic G, Ferguson-Smith AC, Watt FM
Nature 2013 Dec 12;504(7479):277-281
Nature 2013 Dec 12;504(7479):277-281
Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division.
Lemaître F, Moreau HD, Vedele L, Bousso P
Journal of immunology (Baltimore, Md. : 1950) 2013 Aug 15;191(4):1578-85
Journal of immunology (Baltimore, Md. : 1950) 2013 Aug 15;191(4):1578-85
Estrogen and progesterone together expand murine endometrial epithelial progenitor cells.
Janzen DM, Cheng D, Schafenacker AM, Paik DY, Goldstein AS, Witte ON, Jaroszewicz A, Pellegrini M, Memarzadeh S
Stem cells (Dayton, Ohio) 2013 Apr;31(4):808-22
Stem cells (Dayton, Ohio) 2013 Apr;31(4):808-22
The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability.
Szabo AZ, Fong S, Yue L, Zhang K, Strachan LR, Scalapino K, Mancianti ML, Ghadially R
Stem cells (Dayton, Ohio) 2013 Apr;31(4):786-99
Stem cells (Dayton, Ohio) 2013 Apr;31(4):786-99
Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease.
Sosunov AA, Guilfoyle E, Wu X, McKhann GM 2nd, Goldman JE
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Apr 24;33(17):7439-50
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Apr 24;33(17):7439-50
Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation.
Paik DY, Janzen DM, Schafenacker AM, Velasco VS, Shung MS, Cheng D, Huang J, Witte ON, Memarzadeh S
Stem cells (Dayton, Ohio) 2012 Nov;30(11):2487-97
Stem cells (Dayton, Ohio) 2012 Nov;30(11):2487-97
Increased protection from vaccinia virus infection in mice genetically prone to lymphoproliferative disorders.
Seedhom MO, Mathurin KS, Kim SK, Welsh RM
Journal of virology 2012 Jun;86(11):6010-22
Journal of virology 2012 Jun;86(11):6010-22
Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells.
Martinez RJ, Zhang N, Thomas SR, Nandiwada SL, Jenkins MK, Binstadt BA, Mueller DL
Journal of immunology (Baltimore, Md. : 1950) 2012 Jan 1;188(1):170-81
Journal of immunology (Baltimore, Md. : 1950) 2012 Jan 1;188(1):170-81
The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.
Yang C, Cao M, Liu H, He Y, Xu J, Du Y, Liu Y, Wang W, Cui L, Hu J, Gao F
The Journal of biological chemistry 2012 Dec 14;287(51):43094-107
The Journal of biological chemistry 2012 Dec 14;287(51):43094-107
GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state.
Nadendla SK, Hazan A, Ward M, Harper LJ, Moutasim K, Bianchi LS, Naase M, Ghali L, Thomas GJ, Prowse DM, Philpott MP, Neill GW
PloS one 2011;6(5):e20271
PloS one 2011;6(5):e20271
High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event.
Quéré R, Andradottir S, Brun AC, Zubarev RA, Karlsson G, Olsson K, Magnusson M, Cammenga J, Karlsson S
Leukemia 2011 Mar;25(3):515-26
Leukemia 2011 Mar;25(3):515-26
PTEN loss accelerates KrasG12D-induced pancreatic cancer development.
Hill R, Calvopina JH, Kim C, Wang Y, Dawson DW, Donahue TR, Dry S, Wu H
Cancer research 2010 Sep 15;70(18):7114-24
Cancer research 2010 Sep 15;70(18):7114-24
CD44 expression is developmentally regulated in the mouse lens and increases in the lens epithelium after injury.
Desai VD, Wang Y, Simirskii VN, Duncan MK
Differentiation; research in biological diversity 2010 Feb;79(2):111-9
Differentiation; research in biological diversity 2010 Feb;79(2):111-9
Two host factors regulate persistence of H7-specific T cells injected in tumor-bearing mice.
Meunier MC, Baron C, Perreault C
PloS one 2009;4(1):e4116
PloS one 2009;4(1):e4116
Effects of Culturing on the Stability of the Putative Murine Adipose Derived Stem Cells Markers.
Maddox JR, Liao X, Li F, Niyibizi C
The open stem cell journal 2009 Jan 1;1:54-61
The open stem cell journal 2009 Jan 1;1:54-61
Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection.
Anis MM, Fulton SA, Reba SM, Harding CV, Boom WH
Infection and immunity 2007 May;75(5):2260-8
Infection and immunity 2007 May;75(5):2260-8
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of C57BL/6 splenocytes with 0.06 µg of Rat IgG2b kappa Isotype Control Biotin (Product # 13-4031-82) (open histogram) or 0.06 µg of Anti-Human/Mouse CD44 Biotin (filled histogram) followed by Streptavidin PE (Product # 12-4317-87). Total viable cells were used for analysis.
- Conjugate
- Biotin
