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- Product number
- 21775-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21775-1-AP, RRID:AB_10734593
- Product name
- IFIH1/MDA5 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IFIH1/MDA5 antibody (Cat. #21775-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NUDT7 Modulates the UBA52-SREBF1 Signaling Axis to Promote PRRSV Replication via Lipid Synthesis.
The segmented flavivirus ALSV-encoded nucleoprotein VP2 inhibits type I interferon production by targeting RIG-I.
A dual role for ER-Golgi cargo receptor LMAN1 in supporting CSFV replication and restraining RLR signaling.
PEDV infection induces ferroptosis in Vero cells via an ACSL4-mediated lipid peroxidation pathway.
Zinc finger protein ZNF33B facilitates Japanese encephalitis virus replication by regulating m(6)A modification on Ifih1 and Irf3 transcripts to antagonize antiviral response.
CDK10 suppresses nucleic acid sensors-mediated antitumor immunity.
Methadone maintenance therapy alters the expression of PLK1 and IFIH1 in patients with heroin addiction: a case-control study.
YWHAZ downregulated innate immune responses to RNA viruses by inhibiting the IRF3 signaling pathway.
African swine fever virus pMGF505-9R enhances RIG-I-like receptor signaling by promoting RING finger protein 125 autoubiquitination.
Cytokine-independent induction of LGP2/DHX58 in viral infection.
ATP-dependent one-dimensional movement maintains immune homeostasis by suppressing spontaneous MDA5 filament assembly.
Nuclear receptor ESRRA promotes ERα-positive breast cancer through dual action on super enhancers and promoters to regulate gene transcriptional programs.
PNMA4 enhances anti-RNA virus immunity by promoting RIG-I signaling pathway.
Incorporation of 5-methylcytidine alleviates RIG-I-mediated innate immune responses to a self-amplifying RNA vaccine.
The effect and mechanism of sanguinarine against PCV2 based on the analysis of network pharmacology and TMT quantitative proteomics.
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer.
MDA5 protein mediating persistent ER stress/unfolded protein response contributes to endothelial-mesenchymal-transition of lung microvascular endothelial cell in dermatomyositis.
Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes.
Porcine reproductive and respiratory syndrome virus NSP5 exploited UBE2L6 to promote viral replication via antagonising host RLRs and ISGylation.
TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein.
Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors.
DNAJA2 inhibits Newcastle disease virus replication by targeting its V protein to modulate the MDA5-MAVS pathway.
Gallic acid inhibits EMCV infection via targeting the interaction between TBK1 and IRF3 to promote IFN-β expression.
Mitochondrial RNA cytosolic leakage drives the SASP.
BVDV antagonizes the antiviral activity of MDA5 by promoting its degradation via CCDC50-dependent selective autophagy.
Linker histone H1.3 promotes IFN-β production targeting MDA5 signaling to inhibit EMCV infection.
5' cap sequestration is required for sensing of unspliced HIV-1 RNA by MDA5.
Porcine epidemic diarrhea virus nsp14 inhibited IFN-Ⅰ production by targeting RIG-I for degradation.
RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation.
Differential Effects of Extracellular Vesicles from Two Different Glioblastomas on Normal Human Brain Cells.
Distinct pathways utilized by METTL3 to regulate antiviral innate immune response.
Natural evidence of coronaviral 2'-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding.
Hyperacetylated microtubules assist porcine deltacoronavirus nsp8 to degrade MDA5 via SQSTM1/p62-dependent selective autophagy.
Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation.
Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.
IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus.
Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway.
Transcriptome-Wide N6-Methyladenosine Alternations in Pulmonary Arteries of Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats and Novel Therapeutic Targets.
Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition.
Mitochondrial RNA cytosolic leakage drives the SASP.
Systems genetics of influenza A virus-infected mice identifies TRIM21 as a critical regulator of pulmonary innate immune response.
IFNα-induced BST2(+) tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.
A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells.
IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly(I:C) in Murine Macrophages.
ADAR1 links R-loop homeostasis to ATR activation in replication stress response.
Incorporation of 5 methylcytidine alleviates innate immune response to self-amplifying RNA vaccine.
CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS.
IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway.
Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses.
STAT3 regulates antiviral immunity by suppressing excessive interferon signaling.
LGP2 Promotes Type I Interferon Production To Inhibit PRRSV Infection via Enhancing MDA5-Mediated Signaling.
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.
IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus.
A genome-wide optical pooled screen reveals regulators of cellular antiviral responses.
Porcine Epidemic Diarrhea Virus nsp7 Inhibits MDA5 Dephosphorylation to Antagonize Type I Interferon Production.
Systematic Analysis of Molecular Subtypes Based on the Expression Profile of Immune-Related Genes in Pancreatic Cancer.
CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses.
Peste des Petits Ruminants Virus Upregulates STING to Activate ATF6-Mediated Autophagy.
Direct Interaction of Coronavirus Nonstructural Protein 3 with Melanoma Differentiation-Associated Gene 5 Modulates Type I Interferon Response during Coronavirus Infection.
Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing.
CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses.
RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency.
Impaired Antiviral Responses to Extracellular Double-Stranded RNA and Cytosolic DNA, but Not to Interferon-α Stimulation, in TRIM56-Deficient Cells.
STING1 is essential for an RNA-virus triggered autophagy.
HSP27 Protein Dampens Encephalomyocarditis Virus Replication by Stabilizing Melanoma Differentiation-Associated Gene 5.
Constitutive TRIM22 Expression in the Respiratory Tract Confers a Pre-Existing Defence Against Influenza A Virus Infection.
Curcumol inhibits encephalomyocarditis virus by promoting IFN-β secretion.
Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
Response of human macrophages to gamma radiation is mediated via expression of endogenous retroviruses.
Murine norovirus replicase augments RIG-I-like receptors-mediated antiviral interferon response.
ALS-associated genes in SCA2 mouse spinal cord transcriptomes.
Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response.
ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress.
Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy.
Ribosome biogenesis restricts innate immune responses to virus infection and DNA.
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.
Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity.
RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon β.
HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction.
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
ARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65.
TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity.
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.
The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern To Promote Beta Interferon Induction via a Toll-Like-Receptor-Related TRAF3-Independent Mechanism.
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
Yan Y, Li C, Zhang J, Li R, Yin B, Zhang S, Zhang Y, Zhang X, Han J, Huang J
International journal of biological sciences 2026;22(3):1590-1610
International journal of biological sciences 2026;22(3):1590-1610
The segmented flavivirus ALSV-encoded nucleoprotein VP2 inhibits type I interferon production by targeting RIG-I.
Pan M, Song Z, Wang M, Zhao M, Fang S, Jin F, Tan Q, Xu W, Che L, Liu N, Sui L, Liu Q, Hou Z, Zhao Y
Microbiology spectrum 2026 Mar 3;14(3):e0248425
Microbiology spectrum 2026 Mar 3;14(3):e0248425
A dual role for ER-Golgi cargo receptor LMAN1 in supporting CSFV replication and restraining RLR signaling.
Han K, Chang Z, Li N, Xiao D, Song M, Wang T, Guo K, Zhang L, Deng W
Journal of virology 2026 Mar 24;100(3):e0006926
Journal of virology 2026 Mar 24;100(3):e0006926
PEDV infection induces ferroptosis in Vero cells via an ACSL4-mediated lipid peroxidation pathway.
Weng Q, Li Y, Wei Y, Wang S, Hu T, Pei Z, Wang K, Hu G
Archives of virology 2026 Mar 18;171(4)
Archives of virology 2026 Mar 18;171(4)
Zinc finger protein ZNF33B facilitates Japanese encephalitis virus replication by regulating m(6)A modification on Ifih1 and Irf3 transcripts to antagonize antiviral response.
Du J, Li C, Zhang J, Luo J, Zhang H, Chen H, Li X, Qian P
Cell & bioscience 2026 Jan 4;16(1):13
Cell & bioscience 2026 Jan 4;16(1):13
CDK10 suppresses nucleic acid sensors-mediated antitumor immunity.
Xu G, Guo F, He C, Wang X, Xiang B, Fan L, Chen B, Peng J, Sun Y, Shi J, Xing X, Yao Y, Dai P, Li H, Xiong W, Liu H, Xiao R, Qing G, Jiang C, Jiang B, Lei X, Zhang J
Nature cancer 2026 Feb;7(2):283-303
Nature cancer 2026 Feb;7(2):283-303
Methadone maintenance therapy alters the expression of PLK1 and IFIH1 in patients with heroin addiction: a case-control study.
Zhang B, Sang Y, Aihemaijiang M, Feng L, Muhedaner Y, Dong M, Hu X
Psychopharmacology 2026 Feb 27;
Psychopharmacology 2026 Feb 27;
YWHAZ downregulated innate immune responses to RNA viruses by inhibiting the IRF3 signaling pathway.
Li S, Han J, Wang H, Hou J, Wang L, Hou Z, Zhang Y, Dou X, Xie J, Li H, Li X, Feng R
mSphere 2026 Apr 28;11(4):e0003826
mSphere 2026 Apr 28;11(4):e0003826
African swine fever virus pMGF505-9R enhances RIG-I-like receptor signaling by promoting RING finger protein 125 autoubiquitination.
Zhao J, Zhang X, Mou C, Shi K, Chen Z
The Journal of biological chemistry 2025 Oct;301(10):110669
The Journal of biological chemistry 2025 Oct;301(10):110669
Cytokine-independent induction of LGP2/DHX58 in viral infection.
Liu Y, Tong X, Wang R, Li ZG, Xie Z, Wang D, Gu W, Li K
The Journal of general virology 2025 Oct;106(10)
The Journal of general virology 2025 Oct;106(10)
ATP-dependent one-dimensional movement maintains immune homeostasis by suppressing spontaneous MDA5 filament assembly.
Han XP, Rao M, Chang Y, Zhu JY, Cheng J, Li YT, Qiong W, Ye SC, Zhang Q, Zhang SQ, Chen LL, Hou F, Zhong J, Liu J
Cell research 2025 Nov;35(11):900-912
Cell research 2025 Nov;35(11):900-912
Nuclear receptor ESRRA promotes ERα-positive breast cancer through dual action on super enhancers and promoters to regulate gene transcriptional programs.
Zheng ZZ, Chen L, Hu GS, Peng BL, Huang QX, Wang A, Wang C, Liu W
Science bulletin 2025 Nov 30;70(22):3822-3839
Science bulletin 2025 Nov 30;70(22):3822-3839
PNMA4 enhances anti-RNA virus immunity by promoting RIG-I signaling pathway.
Song H, Li ZW, Xie YT, Tang X, Hu YT, Tan Y, Huang Y, Cheng YL, Pei G, Kuang M
International immunopharmacology 2025 Nov 14;165:115446
International immunopharmacology 2025 Nov 14;165:115446
Incorporation of 5-methylcytidine alleviates RIG-I-mediated innate immune responses to a self-amplifying RNA vaccine.
Akahata W, Komori M, Morey AL, Quiñones-Molina AA, Hood JB, Fofana J, Romero L, Peters E, Webber JD, Meeks T, Przygonska PA, Steinberg I, Ober E, Kim T, Rogan DC, Matsuda K, Smith JF, Gummuluru S, Connors M, Akiyama H
Science translational medicine 2025 Nov 12;17(824):eadz2276
Science translational medicine 2025 Nov 12;17(824):eadz2276
The effect and mechanism of sanguinarine against PCV2 based on the analysis of network pharmacology and TMT quantitative proteomics.
Zhang S, Li H, Wang X, Sun P, Zhang H, Yin W, Fan K, Yang H, Zhang Z, Zhong J, Sun Y, Sun N
International journal of biological macromolecules 2025 Mar;296:139767
International journal of biological macromolecules 2025 Mar;296:139767
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer.
Xu J, Ren Y, Lu J, Qin F, Yang D, Tang C, Yang Y, Xu J, Liu T, Yi P
Clinical and translational medicine 2025 Mar;15(3):e70249
Clinical and translational medicine 2025 Mar;15(3):e70249
MDA5 protein mediating persistent ER stress/unfolded protein response contributes to endothelial-mesenchymal-transition of lung microvascular endothelial cell in dermatomyositis.
Zhao LQ, Yang XQ, Niu Q, Feng X, Zhang HD, Ye SY, Jiang LJ, Yu F, Ye H, Ma WL
Cell communication and signaling : CCS 2025 Mar 23;23(1):149
Cell communication and signaling : CCS 2025 Mar 23;23(1):149
Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes.
Patel D, Tiusanen V, Karttunen K, Pihlajamaa P, Sahu B
Communications biology 2025 Jul 3;8(1):992
Communications biology 2025 Jul 3;8(1):992
Porcine reproductive and respiratory syndrome virus NSP5 exploited UBE2L6 to promote viral replication via antagonising host RLRs and ISGylation.
Zhu Z, Chen L, Zhang M, Lin Q, Yan Y, Wang W, Wen W, Zhang Z, Li X
Veterinary research 2025 Jul 3;56(1):136
Veterinary research 2025 Jul 3;56(1):136
TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein.
He J, Kuang Y, Xu K, Huang R, Yang X, Deng L, Feng X, Ren Y, Yang J, Yuan L
Viruses 2025 Jan 30;17(2)
Viruses 2025 Jan 30;17(2)
Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors.
Laliberté A, Prelli Bozzo C, Acharya D, De Luna A, Hirschenberger M, Zhu J, Volcic M, Stolp B, Rodriguez-Quinteros CM, Fackler OT, Gack MU, Sparrer KMJ, Kirchhoff F
Nature communications 2025 Dec 7;16(1):10945
Nature communications 2025 Dec 7;16(1):10945
DNAJA2 inhibits Newcastle disease virus replication by targeting its V protein to modulate the MDA5-MAVS pathway.
Mo J, Zhang F, Jiang Y, Li M, Wu S, Chen R
BMC microbiology 2025 Dec 22;26(1):84
BMC microbiology 2025 Dec 22;26(1):84
Gallic acid inhibits EMCV infection via targeting the interaction between TBK1 and IRF3 to promote IFN-β expression.
Zhang Y, Wen Y, Xue W, Zhang T, Hou J, Chen X, Feng R, Tan C
Microbiology spectrum 2025 Dec 2;13(12):e0152425
Microbiology spectrum 2025 Dec 2;13(12):e0152425
Mitochondrial RNA cytosolic leakage drives the SASP.
Victorelli S, Eppard M, Martini H, Woo SH, Everts SPA, Lee G, Pirius N, Han N, Liang EY, Franco AC, Han Y, Saul D, Nóvoa E, Nogueiras R, Splinter PL, O'Hara SP, Morgenthaler O, Valenzuela-Pérez L, Kim Lee HS, Jurk D, LaRusso NF, Hirsova P, Passos JF
Nature communications 2025 Dec 15;16(1):10992
Nature communications 2025 Dec 15;16(1):10992
BVDV antagonizes the antiviral activity of MDA5 by promoting its degradation via CCDC50-dependent selective autophagy.
Wang Z, Liu S, Xu L, Wang J, Ye S, Cai S, Jia K, Li S
Veterinary microbiology 2025 Aug;307:110601
Veterinary microbiology 2025 Aug;307:110601
Linker histone H1.3 promotes IFN-β production targeting MDA5 signaling to inhibit EMCV infection.
Li H, Dou X, Wang N, Lian R, Li S, Xie J, Li X, Yang Y, Wen Y, Feng R
Molecular immunology 2025 Aug;184:137-148
Molecular immunology 2025 Aug;184:137-148
5' cap sequestration is required for sensing of unspliced HIV-1 RNA by MDA5.
Hughes IK, Kharytonchyk S, Ramaswamy S, Jalloh S, Hood JB, He X, Henderson AJ, Akiyama H, Telesnitsky A, Gummuluru S
bioRxiv : the preprint server for biology 2025 Aug 25;
bioRxiv : the preprint server for biology 2025 Aug 25;
Porcine epidemic diarrhea virus nsp14 inhibited IFN-Ⅰ production by targeting RIG-I for degradation.
Li S, Wang L, Wen Y, Han J, Hou J, Hou Z, Xie J, Li H, Li X, Yang Y, Feng R
Virology 2025 Apr;605:110451
Virology 2025 Apr;605:110451
RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation.
Li G, Zhang J, Zhao Z, Wang J, Li J, Xu W, Cui Z, Sun P, Yuan H, Wang T, Li K, Bai X, Ma X, Li P, Fu Y, Cao Y, Bao H, Li D, Liu Z, Zhu N, Tang L, Lu Z
EMBO reports 2024 Oct;25(10):4594-4624
EMBO reports 2024 Oct;25(10):4594-4624
Differential Effects of Extracellular Vesicles from Two Different Glioblastomas on Normal Human Brain Cells.
Wang M, Graner AN, Knowles B, McRae C, Fringuello A, Paucek P, Gavrilovic M, Redwine M, Hanson C, Coughlan C, Grimaldo-Garcia S, Metzger B, Bolus V, Kopper TJ, Smith M, Zhou W, Lenz M, Abosch A, Ojemann S, Lillehei KO, Yu X, Graner MW
Neurology international 2024 Nov 6;16(6):1355-1384
Neurology international 2024 Nov 6;16(6):1355-1384
Distinct pathways utilized by METTL3 to regulate antiviral innate immune response.
Hao H, Zhang F, Chen Z, Tan Z, Zhang H, Feng X, Zhang X, Deng T, Zhan G, Luo T, Zhang K, Ding S, Liu H, Zheng Z, Wang Y, Huang F, Guan W
iScience 2024 Nov 15;27(11):111071
iScience 2024 Nov 15;27(11):111071
Natural evidence of coronaviral 2'-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding.
Deng J, Yang S, Li Y, Tan X, Liu J, Yu Y, Ding Q, Fan C, Wang H, Chen X, Liu Q, Guo X, Gong F, Zhou L, Chen Y
Signal transduction and targeted therapy 2024 May 29;9(1):140
Signal transduction and targeted therapy 2024 May 29;9(1):140
Hyperacetylated microtubules assist porcine deltacoronavirus nsp8 to degrade MDA5 via SQSTM1/p62-dependent selective autophagy.
Li Z, Lai Y, Qiu R, Tang W, Ren J, Xiao S, Fang P, Fang L
Journal of virology 2024 Mar 19;98(3):e0000324
Journal of virology 2024 Mar 19;98(3):e0000324
Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation.
Wu B, Li D, Bai H, Mo R, Li H, Xie J, Zhang X, Yang Y, Li H, Idris A, Li X, Feng R
Molecular immunology 2024 Jun;170:131-143
Molecular immunology 2024 Jun;170:131-143
Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.
Li D, Mo R, Li X, Cheng R, Xie J, Li H, Yang Y, Li S, Li H, Yan Z, Wei S, Idris A, Li X, Feng R
mSphere 2024 Jun 25;9(6):e0023624
mSphere 2024 Jun 25;9(6):e0023624
IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus.
Guney MH, Nagalekshmi K, McCauley SM, Carbone C, Aydemir O, Luban J
Proceedings of the National Academy of Sciences of the United States of America 2024 Jul 16;121(29):e2404349121
Proceedings of the National Academy of Sciences of the United States of America 2024 Jul 16;121(29):e2404349121
Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway.
Song Y, Li H, Lian R, Dou X, Li S, Xie J, Li X, Feng R, Li Z
Viruses 2024 Jan 24;16(2)
Viruses 2024 Jan 24;16(2)
Transcriptome-Wide N6-Methyladenosine Alternations in Pulmonary Arteries of Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats and Novel Therapeutic Targets.
Feng Y, Yu Z, Tang M, Li J, Peng B, Juaiti M, Tang Y, Liang B, Ouyang M, Liu Q, Song J
Biomedicines 2024 Feb 4;12(2)
Biomedicines 2024 Feb 4;12(2)
Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition.
Li Y, Shen S, Guo H, Li H, Zhang L, Zhang B, Yu XF, Wei W
Cell reports 2024 Feb 27;43(2):113749
Cell reports 2024 Feb 27;43(2):113749
Mitochondrial RNA cytosolic leakage drives the SASP.
Victorelli S, Eppard M, Woo SH, Everts SPA, Martini H, Pirius N, Franco AC, Han Y, Saul D, Splinter PL, O'Hara SP, Valenzuela-Pérez L, Lee HSK, Jurk D, LaRusso NF, Hirsova P, Passos JF
Research square 2024 Aug 27;
Research square 2024 Aug 27;
Systems genetics of influenza A virus-infected mice identifies TRIM21 as a critical regulator of pulmonary innate immune response.
Li ZA, Bajpai AK, Wang R, Liu Y, Webby RJ, Wilk E, Gu W, Schughart K, Li K, Lu L
Virus research 2024 Apr;342:199335
Virus research 2024 Apr;342:199335
IFNα-induced BST2(+) tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.
Zheng C, Wang J, Zhou Y, Duan Y, Zheng R, Xie Y, Wei X, Wu J, Shen H, Ye M, Kong B, Liu Y, Xu P, Zhang Q, Liang T
Cell reports 2024 Apr 23;43(4):114088
Cell reports 2024 Apr 23;43(4):114088
A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells.
Wang M, Graner AN, Knowles B, McRae C, Fringuello A, Paucek P, Gavrilovic M, Redwine M, Hanson C, Coughlan C, Metzger B, Bolus V, Kopper T, Smith M, Zhou W, Lenz M, Abosch A, Ojemann S, Lillehei KO, Yu X, Graner MW
bioRxiv : the preprint server for biology 2024 Apr 12;
bioRxiv : the preprint server for biology 2024 Apr 12;
IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly(I:C) in Murine Macrophages.
Aparici-Herraiz I, Sánchez-Sánchez G, Batlle C, Rehues P, López-Serrat M, Valverde-Estrella L, Lloberas J, Celada A
Journal of innate immunity 2023;15(1):297-316
Journal of innate immunity 2023;15(1):297-316
ADAR1 links R-loop homeostasis to ATR activation in replication stress response.
Zhang B, Li Y, Zhang J, Wang Y, Liang C, Lu T, Zhang C, Liu L, Qin Y, He J, Zhao X, Yu J, Hao J, Yang J, Li MJ, Yao Z, Ma S, Cheng H, Cheng T, Shi L
Nucleic acids research 2023 Nov 27;51(21):11668-11687
Nucleic acids research 2023 Nov 27;51(21):11668-11687
Incorporation of 5 methylcytidine alleviates innate immune response to self-amplifying RNA vaccine.
Komori M, Morey AL, Quiñones-Molina AA, Fofana J, Romero L, Peters E, Matsuda K, Gummuluru S, Smith JF, Akahata W, Akiyama H
bioRxiv : the preprint server for biology 2023 Nov 1;
bioRxiv : the preprint server for biology 2023 Nov 1;
CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS.
Yi J, Wang L, Hu GS, Zhang YY, Du J, Ding JC, Ji X, Shen HF, Huang HH, Ye F, Liu W
The EMBO journal 2023 May 15;42(10):e112408
The EMBO journal 2023 May 15;42(10):e112408
IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway.
Chen L, Li X, Deng Y, Bi Y, Yan Z, Yang Y, Zhang X, Li H, Xie J, Feng R
Viruses 2023 Mar 28;15(4)
Viruses 2023 Mar 28;15(4)
Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses.
Deng S, He W, Gong AY, Li M, Wang Y, Xia Z, Zhang XT, Huang Pacheco AS, Naqib A, Jenkins M, Swanson PC, Drescher KM, Strauss-Soukup JK, Belshan M, Chen XM
Nature communications 2023 Mar 16;14(1):1456
Nature communications 2023 Mar 16;14(1):1456
STAT3 regulates antiviral immunity by suppressing excessive interferon signaling.
Liu S, Liu S, Yu Z, Zhou W, Zheng M, Gu R, Hong J, Yang Z, Chi X, Guo G, Li X, Chen N, Huang S, Wang S, Chen JL
Cell reports 2023 Jul 25;42(7):112806
Cell reports 2023 Jul 25;42(7):112806
LGP2 Promotes Type I Interferon Production To Inhibit PRRSV Infection via Enhancing MDA5-Mediated Signaling.
Zhu Z, Zhang M, Yuan L, Xu Y, Zhou H, Lian Z, Liu P, Li X
Journal of virology 2023 Jan 31;97(1):e0184322
Journal of virology 2023 Jan 31;97(1):e0184322
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Zheng W, Zhou Z, Rui Y, Ye R, Xia F, Guo F, Liu X, Su J, Lou M, Yu XF
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
Burgess HM, Grande R, Riccio S, Dinesh I, Winkler GS, Depledge DP, Mohr I
EMBO reports 2023 Dec 6;24(12):e56327
EMBO reports 2023 Dec 6;24(12):e56327
E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IFIH1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human IFIH1. This antibody recognizes human antigen. The IFIH1 antibody has been validated for the following applications: ELISA, WB analysis.
