66770-1-Ig

antibody from Proteintech Group

Targeting: IFIH1 Hlcd, IDDM19, MDA-5, MDA5

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66770-1-Ig

Provider

Proteintech Group

Product name

IFIH1/MDA5 antibody

Antibody type

Monoclonal

Description

IFIH1/MDA5 antibody (Cat. #66770-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3D8B11

Vial size

20ul, 150ul

References

Submitted references

NUDT7 Modulates the UBA52-SREBF1 Signaling Axis to Promote PRRSV Replication via Lipid Synthesis.

Yan Y, Li C, Zhang J, Li R, Yin B, Zhang S, Zhang Y, Zhang X, Han J, Huang J
International journal of biological sciences 2026;22(3):1590-1610

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ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal-Fetal Interface.

Chen X, Xu X, Chen J, Zhang H, Zheng W, Yu W, Hu X, Cao B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e05491

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Immunohistochemical Profiling of Interferon-Stimulated Genes in Histopathological Specimens: A Potential Screening Approach for Viral Infections.

Thomsen C, Birkelund S, Røge R
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2025 Jun;133(6):e70034

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Negative regulation of SREBP-1/FAS signaling molecules activates the RIG-1/TBK1-mediated IFN-I pathway to inhibit BVDV replication.

Liu S, Luo A, Que T, Liang Y, Song Y, Liu T, Li J, Li N, Zhang Z, Liu Y, Zhang Z, Zhou Y, Wang X, Zhu Z
Antiviral research 2025 Jan;233:106054

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PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity.

Sun R, Guo Y, Zhang L, Zhang H, Yin B, Li X, Li C, Yang L, Zhang L, Li Z, Huang J
Virologica Sinica 2024 Apr;39(2):264-276

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PI3K/AKT mediated De novo fatty acid synthesis regulates RIG-1/MDA-5-dependent type I IFN responses in BVDV-infected CD8(+)T cells.

Liu SS, Bai TT, Que TL, Luo A, Liang YX, Song YX, Liu TY, Chen JW, Li J, Li N, Zhang ZC, Chen NN, Liu Y, Zhang ZC, Zhou YL, Wang X, Zhu ZB
Veterinary microbiology 2024 Apr;291:110034

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SARS-CoV-2 Nsp8 suppresses MDA5 antiviral immune responses by impairing TRIM4-mediated K63-linked polyubiquitination.

Zhang X, Yang Z, Pan T, Sun Q, Chen Q, Wang PH, Li X, Kuang E
PLoS pathogens 2023 Nov;19(11):e1011792

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Temporally integrated transcriptome analysis reveals ASFV pathology and host response dynamics.

Lv L, Zhang T, Jia H, Zhang Y, Ahsan A, Zhao X, Chen T, Shen Z, Shen N
Frontiers in immunology 2022;13:995998

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DDX56 antagonizes IFN-β production to enhance EMCV replication by inhibiting IRF3 nuclear translocation.

Xu S, Xie J, Zhang X, Chen L, Bi Y, Li X, Idris A, Feng R
Veterinary microbiology 2022 Jan;264:109304

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Host protein, HSP90β, antagonizes IFN-β signaling pathway and facilitates the proliferation of encephalomyocarditis virus in vitro.

Li Q, Li X, Wu B, Niu Y, Ma R, Xie J, Ali A, Feng R
Virus research 2021 Nov;305:198547

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Encephalomyocarditis Virus Abrogates the Interferon Beta Signaling Pathway via Its Structural Protein VP2.

Han Y, Xie J, Xu S, Bi Y, Li X, Zhang H, Idris A, Bai J, Feng R
Journal of virology 2021 Feb 24;95(6)