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- Antigen structure
- References [109]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 15981-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15981-1-AP, RRID:AB_2126302
- Product name
- ISG15 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ISG15 antibody (Cat. #15981-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Ursodeoxycholic acid against TGEV infection via the JAK-STAT1 signaling pathway.
Ursodeoxycholic acid inhibits pneumonia caused by PRCV through the activation of TLR4-IRF3 mediated type Ⅰ interferon pathway.
circFAM53B-1 and circFAM53B-2 drive VSMC phenotypic modulation via ISG15-mediated suppression of SRF.
Engineered Hydroxyapatite-Baicalin Nanorods with Sharp Edges for Broad-Spectrum Antiviral Applications.
JAK/STAT1-interferon-ISGylation networks in breast cancer resistance to inhibitors of FOXM1 and CDK4/6.
LDRT combined with anti-PD-1 promotes tumor regression in head and neck squamous cell carcinoma through tumor metaprogram evolution and immune cell reprogramming.
A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages.
From bats to humans: uncovering ISG15 as a new resistance factor in type 1 diabetes.
Single-cell transcriptomics unravels the early immune landscape of renal allograft rejection and nominates Ccl3-Ccr5 as a therapeutic target.
A robust protocol for proteomic profiling of secreted proteins in conditioned culture medium.
Proteomic and Phosphoproteomic Profiling of Kidney in Rhesus Macaques With SARS-CoV-2 Infection.
IL-10 alleviates ulcerative colitis by regulating mitochondrial function through reducing ISG15 expression.
Microglial NLRC5 drives lysosomal dysfunction to disrupt autophagic flux and promote post-stroke neuroinflammation.
Single-cell atlas of cervical organoids uncovers epithelial immune heterogeneity and intercellular cross-talk during Chlamydia infection.
Rv2647-Mediated NLRP3 Ubiquitination Inhibits Macrophage Pyroptosis and Promotes Mycobacterium tuberculosis Survival.
Trilaciclib triggers a neutrophil-related immune response and sensitizes non-small cell lung cancer to anti-PD-1 therapy.
Transcriptome Landscape of Cancer-Associated Fibroblasts in Human PDAC.
E3 ligase HERC5-catalyzed UGDH isgylation promotes SNAI1-mediated tumor metastasis and cisplatin resistance in oral squamous cell carcinoma.
Pharmacological rescue of mutant p53 triggers spontaneous tumor regression via immune responses.
Innate immune sensing of rotavirus by intestinal epithelial cells leads to diarrhea.
Papain-Like Protease of SARS-CoV-2 Induces Intestinal Inflammation via the ISG15 Pathway: Identification of Natural Compound Inhibitors.
The conserved poxvirus membrane entry-fusion apparatus component OPG147 targets MITA/STING for immune evasion.
Thymoquinone enhances efficacy of cervical Cancer therapeutic vaccines via modulating CD8(+) T cells.
Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity.
Porcine reproductive and respiratory syndrome virus NSP5 exploited UBE2L6 to promote viral replication via antagonising host RLRs and ISGylation.
De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.
Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus.
NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression.
Multi-omics analysis delineates molecular signatures of spinal ependymal tumor.
Harnessing nanozyme-immunomodulation for antiviral defense via Fe-nordihydroguaiaretic acid nano-networks.
DNAJA2 inhibits Newcastle disease virus replication by targeting its V protein to modulate the MDA5-MAVS pathway.
Neuronal TDP-43 pathology drives astrocytic interferon response in a mouse model of ALS.
Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccine.
Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation.
Prefoldin complex promotes interferon-stimulated gene expression and is inhibited by rotavirus VP3.
HERC5 induces podocyte injury in LN by mediated IRF3 ISGylation to promote the production and overactivation of IFN-β in podocytes.
Dose-Dependent Porcine Deltacoronavirus Infection Reveals Linkage Between Infectious Dose and Immune Response.
Molecular profiling reveals the malignant potential in solid pseudopapillary neoplasms of the pancreas.
Identification of potential hub genes associated with recurrent miscarriage through combined transcriptomic and proteomic analysis.
Targeting S100A8/A9-NCF1 axis in tumor microenvironment to prevent tumor metastasis by self-assembled peptide nanofibers.
Porcine reproductive and respiratory syndrome virus nsp5 inhibits the activation of the Nrf2/HO-1 pathway by targeting p62 to antagonize its antiviral activity.
Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation.
Varicella-zoster virus recapitulates its immune evasive behaviour in matured hiPSC-derived neurospheroids.
ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR.
A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models.
ISGylation of the SARS-CoV-2 N protein by HERC5 impedes N oligomerization and thereby viral RNA synthesis.
Signature Proteins in Small Extracellular Vesicles of Granulocytes and CD4(+) T-Cell Subpopulations Identified by Comparative Proteomic Analysis.
Distinct pathways utilized by METTL3 to regulate antiviral innate immune response.
The Effects of Smoking on Telomere Length, Induction of Oncogenic Stress, and Chronic Inflammatory Responses Leading to Aging.
ISGylation of the SARS-CoV-2 N protein by HERC5 impedes N oligomerization and thereby viral RNA synthesis.
SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity.
HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development.
ISG15 promotes tumor progression via IL6/JAK2/STAT3 signaling pathway in ccRCC.
HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages.
Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer.
The neuroprotective effects of caffeic acid phenethyl ester against methamphetamine-induced neurotoxicity.
Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses.
Distinct interactomes of ADAR1 nuclear and cytoplasmic protein isoforms and their responses to interferon induction.
Characterization and noncovalent inhibition of the K63-deubiquitinase activity of SARS-cov-2 PLpro.
Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis.
Integrated analysis of cell-specific gene expression in peripheral blood using ISG15 as a marker of rejection in kidney transplantation.
Discovery of therapeutic targets of quercetin for endometrial carcinoma patients infected with COVID-19 through network pharmacology.
Increase of ISG15 in psoriasis lesions and its promotion of keratinocyte proliferation via the Hif-1α signalling pathway.
Regulation of STING activity in DNA sensing by ISG15 modification.
Characterization of the induction kinetics and antiviral functions of IRF1, ISG15 and ISG20 in cells infected with gammacoronavirus avian infectious bronchitis virus.
Transcriptomic and antiviral analyses of PoIFN-Delta5 against porcine enteric viruses in porcine intestinal epithelial cells.
USP18 promotes endometrial receptivity via the JAK/STAT1 and the ISGylation pathway.
Interferon-τ -induced ISG15-AS regulates endometrial receptivity during early goat pregnancy.
Influenza A and Respiratory Syncytial Virus Trigger a Cellular Response That Blocks Severe Acute Respiratory Syndrome Virus 2 Infection in the Respiratory Tract.
ISG15 and ISGylation modulates cancer stem cell-like characteristics in promoting tumor growth of anaplastic thyroid carcinoma.
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation.
Rift Valley Fever Virus Nucleoprotein Triggers Autophagy to Dampen Antiviral Innate Immune Responses.
E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells.
Effects of growth hormone/estrogen/androgen on COVID-19-type proinflammatory responses in normal human lung epithelial BEAS-2B cells.
Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous Vacuoles.
Identification of ISG15 and ZFP36 as novel hypoxia- and immune-related gene signatures contributing to a new perspective for the treatment of prostate cancer by bioinformatics and experimental verification.
The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction.
Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation.
Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity.
Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity.
Identification of potential immune-related circRNA-miRNA-mRNA regulatory network in cutaneous squamous cell carcinoma.
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
Kinetic Multi-omic Analysis of Responses to SARS-CoV-2 Infection in a Model of Severe COVID-19.
Identification of novel key genes associated with the metastasis of prostate cancer based on bioinformatics prediction and validation.
Degradation of WTAP blocks antiviral responses by reducing the m(6) A levels of IRF3 and IFNAR1 mRNA.
PML-II regulates ERK and AKT signal activation and IFNα-induced cell death.
ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease.
Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
The Overexpression of CD80 and ISG15 Are Associated with the Progression and Metastasis of Breast Cancer by a Meta-Analysis Integrating Three Microarray Datasets.
Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases.
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.
Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.
Deciphering novel biomarkers of lymph node metastasis of thyroid papillary microcarcinoma using proteomic analysis of ultrasound-guided fine-needle aspiration biopsy samples.
Ribosome biogenesis restricts innate immune responses to virus infection and DNA.
ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53.
The S Genome Segment Is Sufficient to Maintain Pathogenicity in Intra-Clade Lassa Virus Reassortants in a Guinea Pig Model.
Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1.
ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway.
Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.
Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing.
ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins.
Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling.
Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity.
Differential interferon pathway gene expression patterns in Rhabdomyosarcoma cells during Enterovirus 71 or Coxsackievirus A16 infection.
ISG15 is a critical microenvironmental factor for pancreatic cancer stem cells.
Sun Z, Liu A, Zhong Y, Song Z, Liao G, Li Y, Song Y, Li Q, Zhang X, Song Z
Veterinary microbiology 2026 May;316:110973
Veterinary microbiology 2026 May;316:110973
Ursodeoxycholic acid inhibits pneumonia caused by PRCV through the activation of TLR4-IRF3 mediated type Ⅰ interferon pathway.
Zhang X, Liao G, Ding J, Sun Z, Zhong Y, Song Y, Li Y, Song Z
Veterinary research 2026 Mar 2;57(1)
Veterinary research 2026 Mar 2;57(1)
circFAM53B-1 and circFAM53B-2 drive VSMC phenotypic modulation via ISG15-mediated suppression of SRF.
Zhao L, Li Y, Bi R, Shen J, Gao Y, Song J, Zhen Z, Zheng B, Lian H, Wen J, Zhang X
Cellular signalling 2026 Jul;143:112498
Cellular signalling 2026 Jul;143:112498
Engineered Hydroxyapatite-Baicalin Nanorods with Sharp Edges for Broad-Spectrum Antiviral Applications.
Huang Z, Tang M, Tan H, Li Y, Liu Y, Wan H
ACS biomaterials science & engineering 2026 Jan 12;12(1):617-630
ACS biomaterials science & engineering 2026 Jan 12;12(1):617-630
JAK/STAT1-interferon-ISGylation networks in breast cancer resistance to inhibitors of FOXM1 and CDK4/6.
Ziegler Y, Kumar S, Saeh CM, Plotner BN, Pento GO, Kim SH, Raghavan A, Schiff R, Katzenellenbogen JA, Katzenellenbogen BS
NPJ breast cancer 2026 Feb 12;12(1)
NPJ breast cancer 2026 Feb 12;12(1)
LDRT combined with anti-PD-1 promotes tumor regression in head and neck squamous cell carcinoma through tumor metaprogram evolution and immune cell reprogramming.
Li G, Yang X, Huang L, Zheng Y, Xu L, Zhang Z, Li J, Li T, Zhang Y, Yang Y, Li Y, Liu Z
Journal of experimental & clinical cancer research : CR 2026 Feb 11;45(1)
Journal of experimental & clinical cancer research : CR 2026 Feb 11;45(1)
A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages.
Dunphy G, Adán-Barrientos I, Fernández-Delgado I, Villarroya-Beltri C, Heras-Murillo I, Moya-Ruiz E, Sánchez-Álvarez M, Jarit-Cabanillas A, Del Pozo MA, Guerra S, Sánchez-Madrid F, Sancho D
Immunity 2026 Feb 10;59(2):306-321.e7
Immunity 2026 Feb 10;59(2):306-321.e7
From bats to humans: uncovering ISG15 as a new resistance factor in type 1 diabetes.
Martin-Vazquez E, Yi X, Bonfim MF, Jawurek S, Zimath PL, Roca-Rivada A, Oliveira JG, Costa-Junior JM, Pattou F, Kerr-Conte J, Nacher M, Montanya E, Ilegems E, Wesley JD, Title AC, Yesildag B, Hagai T, de Beeck AO, Eizirik DL
bioRxiv : the preprint server for biology 2026 Apr 6;
bioRxiv : the preprint server for biology 2026 Apr 6;
Single-cell transcriptomics unravels the early immune landscape of renal allograft rejection and nominates Ccl3-Ccr5 as a therapeutic target.
Wei F, Wang Z, Qi R, Zhang J, Han S, Shi C, Lu T, Zhao Z, Li Z, Li L, Qin W, Ma S, Yang L
Frontiers in immunology 2025;16:1663251
Frontiers in immunology 2025;16:1663251
A robust protocol for proteomic profiling of secreted proteins in conditioned culture medium.
Otsuka T, Hatano A, Matsumoto M, Matsui H
Biology methods & protocols 2025;10(1):bpaf068
Biology methods & protocols 2025;10(1):bpaf068
Proteomic and Phosphoproteomic Profiling of Kidney in Rhesus Macaques With SARS-CoV-2 Infection.
Tian Y, Zhou Y, Wang Q, Li X, Ding T, Wu Y, Tang X, Yang Y, Liu J, Lu S, Yang J
Journal of medical virology 2025 Oct;97(10):e70633
Journal of medical virology 2025 Oct;97(10):e70633
IL-10 alleviates ulcerative colitis by regulating mitochondrial function through reducing ISG15 expression.
He Z, Feng YD, Zhang YX, Gao X, Liu JJ, Liu S, Wu GQ
Cellular signalling 2025 Oct;134:111932
Cellular signalling 2025 Oct;134:111932
Microglial NLRC5 drives lysosomal dysfunction to disrupt autophagic flux and promote post-stroke neuroinflammation.
Xu S, Liu P, Jia J, Sun M, Ma F, Mao R, Li H, Ji S, Bao X, Xia S, Xu Y, Cao X
Journal of neuroinflammation 2025 Oct 31;22(1):253
Journal of neuroinflammation 2025 Oct 31;22(1):253
Single-cell atlas of cervical organoids uncovers epithelial immune heterogeneity and intercellular cross-talk during Chlamydia infection.
Prakash PG, Kumar N, Koster S, Wentland C, Dhanraj J, Gurumuthy RK, Chumduri C
Science advances 2025 Oct 3;11(40):eady1640
Science advances 2025 Oct 3;11(40):eady1640
Rv2647-Mediated NLRP3 Ubiquitination Inhibits Macrophage Pyroptosis and Promotes Mycobacterium tuberculosis Survival.
Jin X, Yan H, Chen X, Feng J, Li G, Yao J, Du X, Feng G
ACS infectious diseases 2025 Oct 10;11(10):2739-2753
ACS infectious diseases 2025 Oct 10;11(10):2739-2753
Trilaciclib triggers a neutrophil-related immune response and sensitizes non-small cell lung cancer to anti-PD-1 therapy.
Gao Y, He Y, Wang C, Zuo R, Tian X, Zuo D, Luo Y, Liu W, Feng Y, Ling A, Yue P, Gong W, Wang Y, Chen L, Liu Z, Chen P, Guo H
Cell reports. Medicine 2025 Nov 18;6(11):102434
Cell reports. Medicine 2025 Nov 18;6(11):102434
Transcriptome Landscape of Cancer-Associated Fibroblasts in Human PDAC.
Tao M, Liu W, Chen J, Liu R, Zou J, Yu B, Wang C, Huang M, Chen Q, Zhang Z, Chen Z, Sun H, Zhou C, Tan S, Zheng Y, Wang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2415196
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2415196
E3 ligase HERC5-catalyzed UGDH isgylation promotes SNAI1-mediated tumor metastasis and cisplatin resistance in oral squamous cell carcinoma.
Zhang X, Liu F, Fang Q, Sun C, Fan J
Biology direct 2025 Mar 5;20(1):27
Biology direct 2025 Mar 5;20(1):27
Pharmacological rescue of mutant p53 triggers spontaneous tumor regression via immune responses.
Li J, Zhang S, Wang B, Dai Y, Wu J, Liu D, Liang Y, Xiao S, Wang Z, Wu J, Zheng D, Chen X, Shi F, Tan K, Ding X, Song H, Zhang S, Lu M
Cell reports. Medicine 2025 Mar 18;6(3):101976
Cell reports. Medicine 2025 Mar 18;6(3):101976
Innate immune sensing of rotavirus by intestinal epithelial cells leads to diarrhea.
Hou G, Son J, Gomez Castro MF, Kawagishi T, Ren X, Roth AN, Antia A, Zeng Q, DeVeaux AL, Feng N, Kohio HP, Baldridge MT, Dermody TS, Zhu S, Ding S
Cell host & microbe 2025 Mar 12;33(3):408-419.e8
Cell host & microbe 2025 Mar 12;33(3):408-419.e8
Papain-Like Protease of SARS-CoV-2 Induces Intestinal Inflammation via the ISG15 Pathway: Identification of Natural Compound Inhibitors.
Wu F, Zhang Z, Lun Q, Hong X, Chen J, Xu X, Xiong X, Zhang Y, Shcherbakov DN, Liu S, Zhou Y, Wang Y, Zhan J, Zhao J, Xu W
Journal of medical virology 2025 Jun;97(6):e70448
Journal of medical virology 2025 Jun;97(6):e70448
The conserved poxvirus membrane entry-fusion apparatus component OPG147 targets MITA/STING for immune evasion.
Yi XM, Li M, Wang SY, Wang SH, Zeng JQ, Lei YL, Zhang Y, Zhu CY, Zhang Y, Song JH, Chen YD, Wang Y, Shu HB, Li S, Wang YY
PLoS pathogens 2025 Jun;21(6):e1013198
PLoS pathogens 2025 Jun;21(6):e1013198
Thymoquinone enhances efficacy of cervical Cancer therapeutic vaccines via modulating CD8(+) T cells.
Che Y, Song B, Song Y, Sun J, Zhao X, Zheng J, Shi Y, Duan Y, Shao Y, Yang T, Yang L
International immunopharmacology 2025 Jun 5;157:114605
International immunopharmacology 2025 Jun 5;157:114605
Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity.
Zhang Y, Fu Y, Qiang L, Zhao M, Lu Z, Zhao Z, Chen G, Lei Z, Chai Q, Ge P, Li B, Wang J, Liu CH, Zhang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2417660
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2417660
Porcine reproductive and respiratory syndrome virus NSP5 exploited UBE2L6 to promote viral replication via antagonising host RLRs and ISGylation.
Zhu Z, Chen L, Zhang M, Lin Q, Yan Y, Wang W, Wen W, Zhang Z, Li X
Veterinary research 2025 Jul 3;56(1):136
Veterinary research 2025 Jul 3;56(1):136
De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.
Grande RC, Lin CC, Cammer M, Emesom ED, Khurram MA, Boutell C, Denes LT, Lionnet T, Wilson AC, Mohr I
Cell reports 2025 Jul 22;44(7):115826
Cell reports 2025 Jul 22;44(7):115826
Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus.
Lin D, Tang C, Wang J, Yang Y, Yang H, Zhou Y, Yu W, Li B, Huang Q, Wang H, An R, Liang X, Yan Y, Yuan L, Du X, Yuan Y, Li Y, Lu S
MedComm 2025 Jan;6(1):e70013
MedComm 2025 Jan;6(1):e70013
NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression.
Xu W, Liu J, Liu Q, Xu J, Zhou L, Liang Z, Huang H, Huang B, Xiao GG, Guo J
Cell reports 2025 Feb 25;44(2):115226
Cell reports 2025 Feb 25;44(2):115226
Multi-omics analysis delineates molecular signatures of spinal ependymal tumor.
Liu W, Ning C, Geng X, Wang B, Zhang Y, Wang C, Liu Y, Zheng G, Wang Y, Wang X, Li D, Jia W
Cellular oncology (Dordrecht, Netherlands) 2025 Dec;48(6):1987-2000
Cellular oncology (Dordrecht, Netherlands) 2025 Dec;48(6):1987-2000
Harnessing nanozyme-immunomodulation for antiviral defense via Fe-nordihydroguaiaretic acid nano-networks.
Wan H, Huang Z, Tang M, Tan H, Deng K, Liu Y, Zhao X, Chen H
Materials today. Bio 2025 Dec;35:102567
Materials today. Bio 2025 Dec;35:102567
DNAJA2 inhibits Newcastle disease virus replication by targeting its V protein to modulate the MDA5-MAVS pathway.
Mo J, Zhang F, Jiang Y, Li M, Wu S, Chen R
BMC microbiology 2025 Dec 22;26(1):84
BMC microbiology 2025 Dec 22;26(1):84
Neuronal TDP-43 pathology drives astrocytic interferon response in a mouse model of ALS.
An J, Hendricks N, Wheeler J, Hincks J, Benitez JAR, Snyder JM, Kraemer BC, Liachko NF, Elkon KB
Journal of neuroinflammation 2025 Dec 20;23(1):29
Journal of neuroinflammation 2025 Dec 20;23(1):29
Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccine.
Zhang J, Chavez EC, Winkler M, Liu J, Carver S, Lin AE, Biswas A, Tamura T, Tseng A, Wang D, Benhamou A, O' Connell AK, Matsuo M, Norton JE, Kenney D, Adamson B, Kleiner RE, Burwitz B, Crossland NA, Douam F, Ploss A
Nature microbiology 2025 Aug;10(8):1902-1917
Nature microbiology 2025 Aug;10(8):1902-1917
Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation.
Zhang X, Nie Z, Wang S, Ma Y, Han D, Hu T, Liu L, Men L, Zhang T, Wu X, Li X, Hu S, Yuan M, Liu L, Wang C, Xu P, Xiang L, Liu J, Zhang Y, Zhu D, Lei H, Zhang L, Li X, Zhao Y, Yan W
Cell metabolism 2025 Aug 5;37(8):1766-1782.e12
Cell metabolism 2025 Aug 5;37(8):1766-1782.e12
Prefoldin complex promotes interferon-stimulated gene expression and is inhibited by rotavirus VP3.
Zhu Y, Song Y, Kumar D, Jackson PK, Prasad BVV, Ding S
Nature communications 2025 Aug 29;16(1):8083
Nature communications 2025 Aug 29;16(1):8083
HERC5 induces podocyte injury in LN by mediated IRF3 ISGylation to promote the production and overactivation of IFN-β in podocytes.
Wei Q, Wang LW, Zhao J, Dong Y, Miao XY, Tian YX, Liu JX, Feng XJ, Liu SX, Liu QJ, Zhang W
International immunopharmacology 2025 Aug 28;161:115059
International immunopharmacology 2025 Aug 28;161:115059
Dose-Dependent Porcine Deltacoronavirus Infection Reveals Linkage Between Infectious Dose and Immune Response.
Bao X, Xia L, Bao W, Sun M, Zhang S
Animals : an open access journal from MDPI 2025 Aug 28;15(17)
Animals : an open access journal from MDPI 2025 Aug 28;15(17)
Molecular profiling reveals the malignant potential in solid pseudopapillary neoplasms of the pancreas.
Li J, Zheng H, Zhang X, Pan B, Lu J, Zhou L, Zhang T, Dai M, Guo J, Wang W, Han X, Xu Q, Hua Y, Kleeff J, Wu H, Liang Z, Liu Q, Liao Q
Cancer letters 2025 Aug 10;625:217788
Cancer letters 2025 Aug 10;625:217788
Identification of potential hub genes associated with recurrent miscarriage through combined transcriptomic and proteomic analysis.
Xu HR, Yang L, Gu Y, Shi Y, Yang SH, Gan J, Gu WW, Zhang X, Wang J
Biomolecules & biomedicine 2025 Apr 26;25(6):1259-1279
Biomolecules & biomedicine 2025 Apr 26;25(6):1259-1279
Targeting S100A8/A9-NCF1 axis in tumor microenvironment to prevent tumor metastasis by self-assembled peptide nanofibers.
Guo Y, Zhang Z, Huang H, Wu Y, Yin L, Zhou Y, Ding F, Hong S, Steinmetz NF, Cai H
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Apr 2;33(4):1502-1518
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Apr 2;33(4):1502-1518
Porcine reproductive and respiratory syndrome virus nsp5 inhibits the activation of the Nrf2/HO-1 pathway by targeting p62 to antagonize its antiviral activity.
Wang F, Amona FM, Pang Y, Zhang Q, Liang Y, Chen X, Ke Y, Chen J, Song C, Wang Y, Li Z, Zhang C, Fang X, Chen X
Journal of virology 2025 Apr 15;99(4):e0158524
Journal of virology 2025 Apr 15;99(4):e0158524
Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation.
Li Y, Dong X, He W, Quan H, Chen K, Cen C, Wei W
Obesity facts 2024;17(1):24-36
Obesity facts 2024;17(1):24-36
Varicella-zoster virus recapitulates its immune evasive behaviour in matured hiPSC-derived neurospheroids.
Govaerts J, Van Breedam E, De Beuckeleer S, Goethals C, D'Incal CP, Di Stefano J, Van Calster S, Buyle-Huybrecht T, Boeren M, De Reu H, Paludan SR, Thiry M, Lebrun M, Sadzot-Delvaux C, Motaln H, Rogelj B, Van Weyenbergh J, De Vos WH, Vanden Berghe W, Ogunjimi B, Delputte P, Ponsaerts P
Frontiers in immunology 2024;15:1458967
Frontiers in immunology 2024;15:1458967
ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR.
Li C, Cai Y, Chen Y, Tong J, Li Y, Liu D, Wang Y, Li Z, Wang Y, Li Q
Redox biology 2024 Sep;75:103262
Redox biology 2024 Sep;75:103262
A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models.
Puray-Chavez M, Eschbach JE, Xia M, LaPak KM, Zhou Q, Jasuja R, Pan J, Xu J, Zhou Z, Mohammed S, Wang Q, Lawson DQ, Djokic S, Hou G, Ding S, Brody SL, Major MB, Goldfarb D, Kutluay SB
Nature communications 2024 Sep 27;15(1):8394
Nature communications 2024 Sep 27;15(1):8394
ISGylation of the SARS-CoV-2 N protein by HERC5 impedes N oligomerization and thereby viral RNA synthesis.
Zhu J, Liu G, Sayyad Z, Goins CM, Stauffer SR, Gack MU
Journal of virology 2024 Sep 17;98(9):e0086924
Journal of virology 2024 Sep 17;98(9):e0086924
Signature Proteins in Small Extracellular Vesicles of Granulocytes and CD4(+) T-Cell Subpopulations Identified by Comparative Proteomic Analysis.
Vázquez-Mera S, Miguéns-Suárez P, Martelo-Vidal L, Rivas-López S, Uller L, Bravo SB, Domínguez-Arca V, Muñoz X, González-Barcala FJ, Nieto Fontarigo JJ, Salgado FJ
International journal of molecular sciences 2024 Oct 9;25(19)
International journal of molecular sciences 2024 Oct 9;25(19)
Distinct pathways utilized by METTL3 to regulate antiviral innate immune response.
Hao H, Zhang F, Chen Z, Tan Z, Zhang H, Feng X, Zhang X, Deng T, Zhan G, Luo T, Zhang K, Ding S, Liu H, Zheng Z, Wang Y, Huang F, Guan W
iScience 2024 Nov 15;27(11):111071
iScience 2024 Nov 15;27(11):111071
The Effects of Smoking on Telomere Length, Induction of Oncogenic Stress, and Chronic Inflammatory Responses Leading to Aging.
Deb S, Berei J, Miliavski E, Khan MJ, Broder TJ, Akurugo TA, Lund C, Fleming SE, Hillwig R, Ross J, Puri N
Cells 2024 May 21;13(11)
Cells 2024 May 21;13(11)
ISGylation of the SARS-CoV-2 N protein by HERC5 impedes N oligomerization and thereby viral RNA synthesis.
Zhu J, Liu G, Goins CM, Stauffer SR, Gack MU
bioRxiv : the preprint server for biology 2024 May 20;
bioRxiv : the preprint server for biology 2024 May 20;
SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity.
Kang JA, Kim YJ, Jang KY, Moon HW, Lee H, Lee S, Song HK, Cho SW, Yoo YS, Han HG, Kim MJ, Chung MJ, Choi CY, Lee C, Chung C, Hur GM, Kim YS, Jeon YJ
Experimental & molecular medicine 2024 Mar;56(3):656-673
Experimental & molecular medicine 2024 Mar;56(3):656-673
HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development.
Jin T, Yang L, Chang C, Luo H, Wang R, Gan Y, Sun Y, Guo Y, Tang R, Chen S, Meng D, Dai P, Liu M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(24):e2307639
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(24):e2307639
ISG15 promotes tumor progression via IL6/JAK2/STAT3 signaling pathway in ccRCC.
Xie W, Zhang Y, Zhang Z, Li Q, Tao L, Zhang R
Clinical and experimental medicine 2024 Jun 29;24(1):140
Clinical and experimental medicine 2024 Jun 29;24(1):140
HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages.
Virgilio MC, Ramnani B, Chen T, Disbennett WM, Lubow J, Welch JD, Collins KL
Nature communications 2024 Jun 29;15(1):5514
Nature communications 2024 Jun 29;15(1):5514
Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer.
Huang G, Liu J, Yu A, Luo C, Zhu J, Wang Y, Dai Z, Zhang L, Feng Z, Lu J, Dong Z, Luo J, Chen W, Chen Z
Cellular and molecular life sciences : CMLS 2024 Jul 8;81(1):292
Cellular and molecular life sciences : CMLS 2024 Jul 8;81(1):292
The neuroprotective effects of caffeic acid phenethyl ester against methamphetamine-induced neurotoxicity.
Yang B, Tan X, Chen Y, Lin J, Liang J, Yue X, Qiao D, Wang H, Du S
Ecotoxicology and environmental safety 2024 Jul 1;279:116497
Ecotoxicology and environmental safety 2024 Jul 1;279:116497
Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses.
Ge Y, Huang J, Chen R, Fu Y, Ling T, Ou X, Rong X, Cheng Y, Lin Y, Zhou F, Lu C, Yuan S, Xu A
PLoS pathogens 2024 Feb;20(2):e1012061
PLoS pathogens 2024 Feb;20(2):e1012061
Distinct interactomes of ADAR1 nuclear and cytoplasmic protein isoforms and their responses to interferon induction.
Vukić D, Cherian A, Keskitalo S, Bong YT, Marônek M, Yadav L, Keegan LP, Varjosalo M, O'Connell MA
Nucleic acids research 2024 Dec 11;52(22):14184-14204
Nucleic acids research 2024 Dec 11;52(22):14184-14204
Characterization and noncovalent inhibition of the K63-deubiquitinase activity of SARS-cov-2 PLpro.
Liu X, Zheng M, Zhang H, Feng B, Li J, Zhang Y, Zhang J, Zhao N, Li C, Song N, Song B, Yang D, Chen J, Qi A, Zhao L, Luo C, Zang Y, Liu H, Li J, Zhang B, Zhou Y, Zheng J
Antiviral research 2024 Aug;228:105944
Antiviral research 2024 Aug;228:105944
Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis.
He Y, Jiang S, Cui Y, Liang J, Zhong Y, Sun Y, Moran MF, Huang Z, He G, Mao X
Cancer letters 2024 Apr 28;588:216797
Cancer letters 2024 Apr 28;588:216797
Integrated analysis of cell-specific gene expression in peripheral blood using ISG15 as a marker of rejection in kidney transplantation.
Zhang Z, Qin Y, Wang Y, Li S, Hu X
Frontiers in immunology 2023;14:1153940
Frontiers in immunology 2023;14:1153940
Discovery of therapeutic targets of quercetin for endometrial carcinoma patients infected with COVID-19 through network pharmacology.
Li K, Liu H, Lin Y, Gu L, Xiang X, Zhu X
Frontiers in oncology 2023;13:1151434
Frontiers in oncology 2023;13:1151434
Increase of ISG15 in psoriasis lesions and its promotion of keratinocyte proliferation via the Hif-1α signalling pathway.
Sun X, Li Y
Experimental dermatology 2023 Nov;32(11):1971-1981
Experimental dermatology 2023 Nov;32(11):1971-1981
Regulation of STING activity in DNA sensing by ISG15 modification.
Lin C, Kuffour EO, Fuchs NV, Gertzen CGW, Kaiser J, Hirschenberger M, Tang X, Xu HC, Michel O, Tao R, Haase A, Martin U, Kurz T, Drexler I, Görg B, Lang PA, Luedde T, Sparrer KMJ, Gohlke H, König R, Münk C
Cell reports 2023 Nov 28;42(11):113277
Cell reports 2023 Nov 28;42(11):113277
Characterization of the induction kinetics and antiviral functions of IRF1, ISG15 and ISG20 in cells infected with gammacoronavirus avian infectious bronchitis virus.
Liu SY, Huang M, Fung TS, Chen RA, Liu DX
Virology 2023 May;582:114-127
Virology 2023 May;582:114-127
Transcriptomic and antiviral analyses of PoIFN-Delta5 against porcine enteric viruses in porcine intestinal epithelial cells.
Zhu X, Fan B, Song S, Gao J, Zhou J, Zhao Y, Guo W, Zhang X, Qian J, Zhu M, Li J, Li Y, Guo R, Fan H, Dong H, Zhang X, Li B
Veterinary microbiology 2023 May;280:109718
Veterinary microbiology 2023 May;280:109718
USP18 promotes endometrial receptivity via the JAK/STAT1 and the ISGylation pathway.
Zhang X, Gong S, Li H, Jiang J, Jia Y, Zhang R, Liu H, Wang A, Jin Y, Lin P
Theriogenology 2023 May;202:110-118
Theriogenology 2023 May;202:110-118
Interferon-τ -induced ISG15-AS regulates endometrial receptivity during early goat pregnancy.
Zhang R, Guo X, Li H, Li Z, Gong S, Li H, Ma Y, Liu H, Gao C, Wang A, Jin Y, Lin P
Theriogenology 2023 Mar 15;199:1-10
Theriogenology 2023 Mar 15;199:1-10
Influenza A and Respiratory Syncytial Virus Trigger a Cellular Response That Blocks Severe Acute Respiratory Syndrome Virus 2 Infection in the Respiratory Tract.
Dee K, Schultz V, Haney J, Bissett LA, Magill C, Murcia PR
The Journal of infectious diseases 2023 Jun 15;227(12):1396-1406
The Journal of infectious diseases 2023 Jun 15;227(12):1396-1406
ISG15 and ISGylation modulates cancer stem cell-like characteristics in promoting tumor growth of anaplastic thyroid carcinoma.
Xu T, Zhu C, Chen J, Song F, Ren X, Wang S, Yi X, Zhang Y, Zhang W, Hu Q, Qin H, Liu Y, Zhang S, Tan Z, Pan Z, Huang P, Ge M
Journal of experimental & clinical cancer research : CR 2023 Jul 27;42(1):182
Journal of experimental & clinical cancer research : CR 2023 Jul 27;42(1):182
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Zheng W, Zhou Z, Rui Y, Ye R, Xia F, Guo F, Liu X, Su J, Lou M, Yu XF
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
Burgess HM, Grande R, Riccio S, Dinesh I, Winkler GS, Depledge DP, Mohr I
EMBO reports 2023 Dec 6;24(12):e56327
EMBO reports 2023 Dec 6;24(12):e56327
MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation.
Noval MG, Spector SN, Bartnicki E, Izzo F, Narula N, Yeung ST, Damani-Yokota P, Dewan MZ, Mezzano V, Rodriguez-Rodriguez BA, Loomis C, Khanna KM, Stapleford KA
Nature communications 2023 Aug 3;14(1):4668
Nature communications 2023 Aug 3;14(1):4668
Rift Valley Fever Virus Nucleoprotein Triggers Autophagy to Dampen Antiviral Innate Immune Responses.
Zhu X, Guan Z, Fang Y, Zhang Y, Guan Z, Li S, Peng K
Journal of virology 2023 Apr 27;97(4):e0181422
Journal of virology 2023 Apr 27;97(4):e0181422
E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells.
Sun W, Hua X, Gu Y, Xu Q, Zhu S, Lv T, Song Y
Clinical immunology (Orlando, Fla.) 2022 Sep;242:109099
Clinical immunology (Orlando, Fla.) 2022 Sep;242:109099
Effects of growth hormone/estrogen/androgen on COVID-19-type proinflammatory responses in normal human lung epithelial BEAS-2B cells.
Zhu Z, Zhao Z, Chen X, Chu Z, He Y, Tan Y, Zhou J, Tang C
BMC molecular and cell biology 2022 Sep 29;23(1):42
BMC molecular and cell biology 2022 Sep 29;23(1):42
Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous Vacuoles.
Hernandez D, Walsh S, Saavedra Sanchez L, Dickinson MS, Coers J
mBio 2022 Oct 26;13(5):e0188822
mBio 2022 Oct 26;13(5):e0188822
Identification of ISG15 and ZFP36 as novel hypoxia- and immune-related gene signatures contributing to a new perspective for the treatment of prostate cancer by bioinformatics and experimental verification.
Lyu F, Li Y, Yan Z, He Q, Cheng L, Zhang P, Liu B, Liu C, Song Y, Xing Y
Journal of translational medicine 2022 May 10;20(1):202
Journal of translational medicine 2022 May 10;20(1):202
The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction.
Walsh SC, Reitano JR, Dickinson MS, Kutsch M, Hernandez D, Barnes AB, Schott BH, Wang L, Ko DC, Kim SY, Valdivia RH, Bastidas RJ, Coers J
Cell host & microbe 2022 Dec 14;30(12):1671-1684.e9
Cell host & microbe 2022 Dec 14;30(12):1671-1684.e9
Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation.
Shahraki AH, Tian R, Zhang C, Fregien NL, Bejarano P, Mirsaeidi M
Lung 2022 Aug;200(4):463-472
Lung 2022 Aug;200(4):463-472
Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity.
Li C, He WF, Li LX, Chen J, Yang GQ, Chang HT, Liu HM
Viruses 2022 Aug 24;14(9)
Viruses 2022 Aug 24;14(9)
Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity.
Cai R, Zhang X, Wang H, Cui T, Halmos G, Sha W, He J, Popovics P, Vidaurre I, Zhang C, Mirsaeidi M, Schally AV
Peptides 2022 Apr;150:170716
Peptides 2022 Apr;150:170716
Identification of potential immune-related circRNA-miRNA-mRNA regulatory network in cutaneous squamous cell carcinoma.
Wei Y, Yang X, Gao L, Yang J, Zheng L, Gao L, Zhou X, Xiang X, Zhang J, Yi C
American journal of cancer research 2021;11(10):4826-4843
American journal of cancer research 2021;11(10):4826-4843
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
Abraham HG, Ulintz PJ, Goo L, Yates JA, Little AC, Bao L, Wu Z, Merajver SD
Frontiers in oncology 2021;11:712041
Frontiers in oncology 2021;11:712041
Kinetic Multi-omic Analysis of Responses to SARS-CoV-2 Infection in a Model of Severe COVID-19.
Cantwell AM, Singh H, Platt M, Yu Y, Lin YH, Ikeno Y, Hubbard G, Xiang Y, Gonzalez-Juarbe N, Dube PH
Journal of virology 2021 Sep 27;95(20):e0101021
Journal of virology 2021 Sep 27;95(20):e0101021
Identification of novel key genes associated with the metastasis of prostate cancer based on bioinformatics prediction and validation.
Song F, Zhang Y, Pan Z, Hu X, Yi Y, Zheng X, Wei H, Huang P
Cancer cell international 2021 Oct 25;21(1):559
Cancer cell international 2021 Oct 25;21(1):559
Degradation of WTAP blocks antiviral responses by reducing the m(6) A levels of IRF3 and IFNAR1 mRNA.
Ge Y, Ling T, Wang Y, Jia X, Xie X, Chen R, Chen S, Yuan S, Xu A
EMBO reports 2021 Nov 4;22(11):e52101
EMBO reports 2021 Nov 4;22(11):e52101
PML-II regulates ERK and AKT signal activation and IFNα-induced cell death.
Meng X, Chen Y, Macip S, Leppard K
Cell communication and signaling : CCS 2021 Jul 2;19(1):70
Cell communication and signaling : CCS 2021 Jul 2;19(1):70
ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.
Bhushan J, Radke JB, Perng YC, Mcallaster M, Lenschow DJ, Virgin HW, Sibley LD
mBio 2020 Oct 6;11(5)
mBio 2020 Oct 6;11(5)
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease.
Olah M, Menon V, Habib N, Taga MF, Ma Y, Yung CJ, Cimpean M, Khairallah A, Coronas-Samano G, Sankowski R, Grün D, Kroshilina AA, Dionne D, Sarkis RA, Cosgrove GR, Helgager J, Golden JA, Pennell PB, Prinz M, Vonsattel JPG, Teich AF, Schneider JA, Bennett DA, Regev A, Elyaman W, Bradshaw EM, De Jager PL
Nature communications 2020 Nov 30;11(1):6129
Nature communications 2020 Nov 30;11(1):6129
Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.
Orfali N, Shan-Krauer D, O'Donovan TR, Mongan NP, Gudas LJ, Cahill MR, Tschan MP, McKenna SL
Molecular oncology 2020 Jun;14(6):1297-1309
Molecular oncology 2020 Jun;14(6):1297-1309
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
Min YQ, Ning YJ, Wang H, Deng F
The Journal of biological chemistry 2020 Jul 10;295(28):9691-9711
The Journal of biological chemistry 2020 Jul 10;295(28):9691-9711
The Overexpression of CD80 and ISG15 Are Associated with the Progression and Metastasis of Breast Cancer by a Meta-Analysis Integrating Three Microarray Datasets.
Li Y, Bai W, Zhang L
Pathology oncology research : POR 2020 Jan;26(1):443-452
Pathology oncology research : POR 2020 Jan;26(1):443-452
Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases.
Dzimianski JV, Scholte FEM, Williams IL, Langley C, Freitas BT, Spengler JR, Bergeron É, Pegan SD
PloS one 2019;14(12):e0226415
PloS one 2019;14(12):e0226415
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.
McFarlane S, Orr A, Roberts APE, Conn KL, Iliev V, Loney C, da Silva Filipe A, Smollett K, Gu Q, Robertson N, Adams PD, Rai TS, Boutell C
PLoS pathogens 2019 Mar;15(3):e1007667
PLoS pathogens 2019 Mar;15(3):e1007667
Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.
Yao Z, Jia X, Megger DA, Chen J, Liu Y, Li J, Sitek B, Yuan Z
Journal of proteome research 2019 Mar 1;18(3):855-864
Journal of proteome research 2019 Mar 1;18(3):855-864
Deciphering novel biomarkers of lymph node metastasis of thyroid papillary microcarcinoma using proteomic analysis of ultrasound-guided fine-needle aspiration biopsy samples.
Lin P, Yao Z, Sun Y, Li W, Liu Y, Liang K, Liu Y, Qin J, Hou X, Chen L
Journal of proteomics 2019 Jul 30;204:103414
Journal of proteomics 2019 Jul 30;204:103414
Ribosome biogenesis restricts innate immune responses to virus infection and DNA.
Bianco C, Mohr I
eLife 2019 Dec 16;8
eLife 2019 Dec 16;8
ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53.
Osei Kuffour E, König R, Häussinger D, Schulz WA, Münk C
mBio 2019 Aug 27;10(4)
mBio 2019 Aug 27;10(4)
The S Genome Segment Is Sufficient to Maintain Pathogenicity in Intra-Clade Lassa Virus Reassortants in a Guinea Pig Model.
Welch SR, Scholte FEM, Albariño CG, Kainulainen MH, Coleman-McCray JD, Guerrero LW, Chakrabarti AK, Klena JD, Nichol ST, Spengler JR, Spiropoulou CF
Frontiers in cellular and infection microbiology 2018;8:240
Frontiers in cellular and infection microbiology 2018;8:240
Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1.
Chauché C, Nogales A, Zhu H, Goldfarb D, Ahmad Shanizza AI, Gu Q, Parrish CR, Martínez-Sobrido L, Marshall JF, Murcia PR
Journal of virology 2018 Mar 1;92(5)
Journal of virology 2018 Mar 1;92(5)
ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway.
Yuan H, Zhou W, Yang Y, Xue L, Liu L, Song Y
Experimental cell research 2018 Jun 1;367(1):47-55
Experimental cell research 2018 Jun 1;367(1):47-55
Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.
Alandijany T, Roberts APE, Conn KL, Loney C, McFarlane S, Orr A, Boutell C
PLoS pathogens 2018 Jan;14(1):e1006769
PLoS pathogens 2018 Jan;14(1):e1006769
Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing.
Bianco C, Mohr I
Journal of virology 2017 May 1;91(9)
Journal of virology 2017 May 1;91(9)
ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins.
Villarroya-Beltri C, Baixauli F, Mittelbrunn M, Fernández-Delgado I, Torralba D, Moreno-Gonzalo O, Baldanta S, Enrich C, Guerra S, Sánchez-Madrid F
Nature communications 2016 Nov 24;7:13588
Nature communications 2016 Nov 24;7:13588
Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling.
Zeng X, Wang S, Chi X, Chen SL, Huang S, Lin Q, Xie B, Chen JL
Research in veterinary science 2016 Feb;104:40-9
Research in veterinary science 2016 Feb;104:40-9
Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity.
Care MA, Stephenson SJ, Barnes NA, Fan I, Zougman A, El-Sherbiny YM, Vital EM, Westhead DR, Tooze RM, Doody GM
Journal of immunology (Baltimore, Md. : 1950) 2016 Aug 15;197(4):1447-59
Journal of immunology (Baltimore, Md. : 1950) 2016 Aug 15;197(4):1447-59
Differential interferon pathway gene expression patterns in Rhabdomyosarcoma cells during Enterovirus 71 or Coxsackievirus A16 infection.
Zhang W, Zhang L, Wu Z, Tien P
Biochemical and biophysical research communications 2014 May 9;447(3):550-5
Biochemical and biophysical research communications 2014 May 9;447(3):550-5
ISG15 is a critical microenvironmental factor for pancreatic cancer stem cells.
Sainz B Jr, Martín B, Tatari M, Heeschen C, Guerra S
Cancer research 2014 Dec 15;74(24):7309-20
Cancer research 2014 Dec 15;74(24):7309-20
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 15981-1-AP(ISG15 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ISG15 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ISG15. This antibody recognizes human antigen. The ISG15 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
