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- Antibody Data
- Antigen structure
- References [54]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 15981-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15981-1-AP, RRID:AB_2126302
- Product name
- ISG15 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ISG15 antibody (Cat. #15981-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation.
SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity.
HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development.
Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses.
Characterization and noncovalent inhibition of the K63-deubiquitinase activity of SARS-cov-2 PLpro.
Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis.
Integrated analysis of cell-specific gene expression in peripheral blood using ISG15 as a marker of rejection in kidney transplantation.
Discovery of therapeutic targets of quercetin for endometrial carcinoma patients infected with COVID-19 through network pharmacology.
Increase of ISG15 in psoriasis lesions and its promotion of keratinocyte proliferation via the Hif-1α signalling pathway.
Regulation of STING activity in DNA sensing by ISG15 modification.
Characterization of the induction kinetics and antiviral functions of IRF1, ISG15 and ISG20 in cells infected with gammacoronavirus avian infectious bronchitis virus.
Transcriptomic and antiviral analyses of PoIFN-Delta5 against porcine enteric viruses in porcine intestinal epithelial cells.
USP18 promotes endometrial receptivity via the JAK/STAT1 and the ISGylation pathway.
Interferon-τ -induced ISG15-AS regulates endometrial receptivity during early goat pregnancy.
Influenza A and Respiratory Syncytial Virus Trigger a Cellular Response That Blocks Severe Acute Respiratory Syndrome Virus 2 Infection in the Respiratory Tract.
ISG15 and ISGylation modulates cancer stem cell-like characteristics in promoting tumor growth of anaplastic thyroid carcinoma.
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation.
Rift Valley Fever Virus Nucleoprotein Triggers Autophagy to Dampen Antiviral Innate Immune Responses.
E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells.
Effects of growth hormone/estrogen/androgen on COVID-19-type proinflammatory responses in normal human lung epithelial BEAS-2B cells.
Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous Vacuoles.
Identification of ISG15 and ZFP36 as novel hypoxia- and immune-related gene signatures contributing to a new perspective for the treatment of prostate cancer by bioinformatics and experimental verification.
The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction.
Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation.
Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity.
Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity.
Identification of potential immune-related circRNA-miRNA-mRNA regulatory network in cutaneous squamous cell carcinoma.
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
Identification of novel key genes associated with the metastasis of prostate cancer based on bioinformatics prediction and validation.
Degradation of WTAP blocks antiviral responses by reducing the m(6) A levels of IRF3 and IFNAR1 mRNA.
PML-II regulates ERK and AKT signal activation and IFNα-induced cell death.
ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease.
Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
The Overexpression of CD80 and ISG15 Are Associated with the Progression and Metastasis of Breast Cancer by a Meta-Analysis Integrating Three Microarray Datasets.
Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases.
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.
Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.
Deciphering novel biomarkers of lymph node metastasis of thyroid papillary microcarcinoma using proteomic analysis of ultrasound-guided fine-needle aspiration biopsy samples.
Ribosome biogenesis restricts innate immune responses to virus infection and DNA.
ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53.
The S Genome Segment Is Sufficient to Maintain Pathogenicity in Intra-Clade Lassa Virus Reassortants in a Guinea Pig Model.
Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1.
ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway.
Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.
Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing.
ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins.
Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling.
Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity.
Differential interferon pathway gene expression patterns in Rhabdomyosarcoma cells during Enterovirus 71 or Coxsackievirus A16 infection.
ISG15 is a critical microenvironmental factor for pancreatic cancer stem cells.
Li Y, Dong X, He W, Quan H, Chen K, Cen C, Wei W
Obesity facts 2024;17(1):24-36
Obesity facts 2024;17(1):24-36
SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity.
Kang JA, Kim YJ, Jang KY, Moon HW, Lee H, Lee S, Song HK, Cho SW, Yoo YS, Han HG, Kim MJ, Chung MJ, Choi CY, Lee C, Chung C, Hur GM, Kim YS, Jeon YJ
Experimental & molecular medicine 2024 Mar;56(3):656-673
Experimental & molecular medicine 2024 Mar;56(3):656-673
HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development.
Jin T, Yang L, Chang C, Luo H, Wang R, Gan Y, Sun Y, Guo Y, Tang R, Chen S, Meng D, Dai P, Liu M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(24):e2307639
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(24):e2307639
Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses.
Ge Y, Huang J, Chen R, Fu Y, Ling T, Ou X, Rong X, Cheng Y, Lin Y, Zhou F, Lu C, Yuan S, Xu A
PLoS pathogens 2024 Feb;20(2):e1012061
PLoS pathogens 2024 Feb;20(2):e1012061
Characterization and noncovalent inhibition of the K63-deubiquitinase activity of SARS-cov-2 PLpro.
Liu X, Zheng M, Zhang H, Feng B, Li J, Zhang Y, Zhang J, Zhao N, Li C, Song N, Song B, Yang D, Chen J, Qi A, Zhao L, Luo C, Zang Y, Liu H, Li J, Zhang B, Zhou Y, Zheng J
Antiviral research 2024 Aug;228:105944
Antiviral research 2024 Aug;228:105944
Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis.
He Y, Jiang S, Cui Y, Liang J, Zhong Y, Sun Y, Moran MF, Huang Z, He G, Mao X
Cancer letters 2024 Apr 28;588:216797
Cancer letters 2024 Apr 28;588:216797
Integrated analysis of cell-specific gene expression in peripheral blood using ISG15 as a marker of rejection in kidney transplantation.
Zhang Z, Qin Y, Wang Y, Li S, Hu X
Frontiers in immunology 2023;14:1153940
Frontiers in immunology 2023;14:1153940
Discovery of therapeutic targets of quercetin for endometrial carcinoma patients infected with COVID-19 through network pharmacology.
Li K, Liu H, Lin Y, Gu L, Xiang X, Zhu X
Frontiers in oncology 2023;13:1151434
Frontiers in oncology 2023;13:1151434
Increase of ISG15 in psoriasis lesions and its promotion of keratinocyte proliferation via the Hif-1α signalling pathway.
Sun X, Li Y
Experimental dermatology 2023 Nov;32(11):1971-1981
Experimental dermatology 2023 Nov;32(11):1971-1981
Regulation of STING activity in DNA sensing by ISG15 modification.
Lin C, Kuffour EO, Fuchs NV, Gertzen CGW, Kaiser J, Hirschenberger M, Tang X, Xu HC, Michel O, Tao R, Haase A, Martin U, Kurz T, Drexler I, Görg B, Lang PA, Luedde T, Sparrer KMJ, Gohlke H, König R, Münk C
Cell reports 2023 Nov 28;42(11):113277
Cell reports 2023 Nov 28;42(11):113277
Characterization of the induction kinetics and antiviral functions of IRF1, ISG15 and ISG20 in cells infected with gammacoronavirus avian infectious bronchitis virus.
Liu SY, Huang M, Fung TS, Chen RA, Liu DX
Virology 2023 May;582:114-127
Virology 2023 May;582:114-127
Transcriptomic and antiviral analyses of PoIFN-Delta5 against porcine enteric viruses in porcine intestinal epithelial cells.
Zhu X, Fan B, Song S, Gao J, Zhou J, Zhao Y, Guo W, Zhang X, Qian J, Zhu M, Li J, Li Y, Guo R, Fan H, Dong H, Zhang X, Li B
Veterinary microbiology 2023 May;280:109718
Veterinary microbiology 2023 May;280:109718
USP18 promotes endometrial receptivity via the JAK/STAT1 and the ISGylation pathway.
Zhang X, Gong S, Li H, Jiang J, Jia Y, Zhang R, Liu H, Wang A, Jin Y, Lin P
Theriogenology 2023 May;202:110-118
Theriogenology 2023 May;202:110-118
Interferon-τ -induced ISG15-AS regulates endometrial receptivity during early goat pregnancy.
Zhang R, Guo X, Li H, Li Z, Gong S, Li H, Ma Y, Liu H, Gao C, Wang A, Jin Y, Lin P
Theriogenology 2023 Mar 15;199:1-10
Theriogenology 2023 Mar 15;199:1-10
Influenza A and Respiratory Syncytial Virus Trigger a Cellular Response That Blocks Severe Acute Respiratory Syndrome Virus 2 Infection in the Respiratory Tract.
Dee K, Schultz V, Haney J, Bissett LA, Magill C, Murcia PR
The Journal of infectious diseases 2023 Jun 15;227(12):1396-1406
The Journal of infectious diseases 2023 Jun 15;227(12):1396-1406
ISG15 and ISGylation modulates cancer stem cell-like characteristics in promoting tumor growth of anaplastic thyroid carcinoma.
Xu T, Zhu C, Chen J, Song F, Ren X, Wang S, Yi X, Zhang Y, Zhang W, Hu Q, Qin H, Liu Y, Zhang S, Tan Z, Pan Z, Huang P, Ge M
Journal of experimental & clinical cancer research : CR 2023 Jul 27;42(1):182
Journal of experimental & clinical cancer research : CR 2023 Jul 27;42(1):182
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Zheng W, Zhou Z, Rui Y, Ye R, Xia F, Guo F, Liu X, Su J, Lou M, Yu XF
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
Burgess HM, Grande R, Riccio S, Dinesh I, Winkler GS, Depledge DP, Mohr I
EMBO reports 2023 Dec 6;24(12):e56327
EMBO reports 2023 Dec 6;24(12):e56327
MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation.
Noval MG, Spector SN, Bartnicki E, Izzo F, Narula N, Yeung ST, Damani-Yokota P, Dewan MZ, Mezzano V, Rodriguez-Rodriguez BA, Loomis C, Khanna KM, Stapleford KA
Nature communications 2023 Aug 3;14(1):4668
Nature communications 2023 Aug 3;14(1):4668
Rift Valley Fever Virus Nucleoprotein Triggers Autophagy to Dampen Antiviral Innate Immune Responses.
Zhu X, Guan Z, Fang Y, Zhang Y, Guan Z, Li S, Peng K
Journal of virology 2023 Apr 27;97(4):e0181422
Journal of virology 2023 Apr 27;97(4):e0181422
E3 ubiquitin ligase RNF6 promotes antiviral immune responses through enhancing the expression of interferon stimulated genes in myeloid cells.
Sun W, Hua X, Gu Y, Xu Q, Zhu S, Lv T, Song Y
Clinical immunology (Orlando, Fla.) 2022 Sep;242:109099
Clinical immunology (Orlando, Fla.) 2022 Sep;242:109099
Effects of growth hormone/estrogen/androgen on COVID-19-type proinflammatory responses in normal human lung epithelial BEAS-2B cells.
Zhu Z, Zhao Z, Chen X, Chu Z, He Y, Tan Y, Zhou J, Tang C
BMC molecular and cell biology 2022 Sep 29;23(1):42
BMC molecular and cell biology 2022 Sep 29;23(1):42
Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous Vacuoles.
Hernandez D, Walsh S, Saavedra Sanchez L, Dickinson MS, Coers J
mBio 2022 Oct 26;13(5):e0188822
mBio 2022 Oct 26;13(5):e0188822
Identification of ISG15 and ZFP36 as novel hypoxia- and immune-related gene signatures contributing to a new perspective for the treatment of prostate cancer by bioinformatics and experimental verification.
Lyu F, Li Y, Yan Z, He Q, Cheng L, Zhang P, Liu B, Liu C, Song Y, Xing Y
Journal of translational medicine 2022 May 10;20(1):202
Journal of translational medicine 2022 May 10;20(1):202
The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction.
Walsh SC, Reitano JR, Dickinson MS, Kutsch M, Hernandez D, Barnes AB, Schott BH, Wang L, Ko DC, Kim SY, Valdivia RH, Bastidas RJ, Coers J
Cell host & microbe 2022 Dec 14;30(12):1671-1684.e9
Cell host & microbe 2022 Dec 14;30(12):1671-1684.e9
Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation.
Shahraki AH, Tian R, Zhang C, Fregien NL, Bejarano P, Mirsaeidi M
Lung 2022 Aug;200(4):463-472
Lung 2022 Aug;200(4):463-472
Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity.
Li C, He WF, Li LX, Chen J, Yang GQ, Chang HT, Liu HM
Viruses 2022 Aug 24;14(9)
Viruses 2022 Aug 24;14(9)
Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity.
Cai R, Zhang X, Wang H, Cui T, Halmos G, Sha W, He J, Popovics P, Vidaurre I, Zhang C, Mirsaeidi M, Schally AV
Peptides 2022 Apr;150:170716
Peptides 2022 Apr;150:170716
Identification of potential immune-related circRNA-miRNA-mRNA regulatory network in cutaneous squamous cell carcinoma.
Wei Y, Yang X, Gao L, Yang J, Zheng L, Gao L, Zhou X, Xiang X, Zhang J, Yi C
American journal of cancer research 2021;11(10):4826-4843
American journal of cancer research 2021;11(10):4826-4843
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
Abraham HG, Ulintz PJ, Goo L, Yates JA, Little AC, Bao L, Wu Z, Merajver SD
Frontiers in oncology 2021;11:712041
Frontiers in oncology 2021;11:712041
Identification of novel key genes associated with the metastasis of prostate cancer based on bioinformatics prediction and validation.
Song F, Zhang Y, Pan Z, Hu X, Yi Y, Zheng X, Wei H, Huang P
Cancer cell international 2021 Oct 25;21(1):559
Cancer cell international 2021 Oct 25;21(1):559
Degradation of WTAP blocks antiviral responses by reducing the m(6) A levels of IRF3 and IFNAR1 mRNA.
Ge Y, Ling T, Wang Y, Jia X, Xie X, Chen R, Chen S, Yuan S, Xu A
EMBO reports 2021 Nov 4;22(11):e52101
EMBO reports 2021 Nov 4;22(11):e52101
PML-II regulates ERK and AKT signal activation and IFNα-induced cell death.
Meng X, Chen Y, Macip S, Leppard K
Cell communication and signaling : CCS 2021 Jul 2;19(1):70
Cell communication and signaling : CCS 2021 Jul 2;19(1):70
ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.
Bhushan J, Radke JB, Perng YC, Mcallaster M, Lenschow DJ, Virgin HW, Sibley LD
mBio 2020 Oct 6;11(5)
mBio 2020 Oct 6;11(5)
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease.
Olah M, Menon V, Habib N, Taga MF, Ma Y, Yung CJ, Cimpean M, Khairallah A, Coronas-Samano G, Sankowski R, Grün D, Kroshilina AA, Dionne D, Sarkis RA, Cosgrove GR, Helgager J, Golden JA, Pennell PB, Prinz M, Vonsattel JPG, Teich AF, Schneider JA, Bennett DA, Regev A, Elyaman W, Bradshaw EM, De Jager PL
Nature communications 2020 Nov 30;11(1):6129
Nature communications 2020 Nov 30;11(1):6129
Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.
Orfali N, Shan-Krauer D, O'Donovan TR, Mongan NP, Gudas LJ, Cahill MR, Tschan MP, McKenna SL
Molecular oncology 2020 Jun;14(6):1297-1309
Molecular oncology 2020 Jun;14(6):1297-1309
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
Min YQ, Ning YJ, Wang H, Deng F
The Journal of biological chemistry 2020 Jul 10;295(28):9691-9711
The Journal of biological chemistry 2020 Jul 10;295(28):9691-9711
The Overexpression of CD80 and ISG15 Are Associated with the Progression and Metastasis of Breast Cancer by a Meta-Analysis Integrating Three Microarray Datasets.
Li Y, Bai W, Zhang L
Pathology oncology research : POR 2020 Jan;26(1):443-452
Pathology oncology research : POR 2020 Jan;26(1):443-452
Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases.
Dzimianski JV, Scholte FEM, Williams IL, Langley C, Freitas BT, Spengler JR, Bergeron É, Pegan SD
PloS one 2019;14(12):e0226415
PloS one 2019;14(12):e0226415
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.
McFarlane S, Orr A, Roberts APE, Conn KL, Iliev V, Loney C, da Silva Filipe A, Smollett K, Gu Q, Robertson N, Adams PD, Rai TS, Boutell C
PLoS pathogens 2019 Mar;15(3):e1007667
PLoS pathogens 2019 Mar;15(3):e1007667
Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.
Yao Z, Jia X, Megger DA, Chen J, Liu Y, Li J, Sitek B, Yuan Z
Journal of proteome research 2019 Mar 1;18(3):855-864
Journal of proteome research 2019 Mar 1;18(3):855-864
Deciphering novel biomarkers of lymph node metastasis of thyroid papillary microcarcinoma using proteomic analysis of ultrasound-guided fine-needle aspiration biopsy samples.
Lin P, Yao Z, Sun Y, Li W, Liu Y, Liang K, Liu Y, Qin J, Hou X, Chen L
Journal of proteomics 2019 Jul 30;204:103414
Journal of proteomics 2019 Jul 30;204:103414
Ribosome biogenesis restricts innate immune responses to virus infection and DNA.
Bianco C, Mohr I
eLife 2019 Dec 16;8
eLife 2019 Dec 16;8
ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53.
Osei Kuffour E, König R, Häussinger D, Schulz WA, Münk C
mBio 2019 Aug 27;10(4)
mBio 2019 Aug 27;10(4)
The S Genome Segment Is Sufficient to Maintain Pathogenicity in Intra-Clade Lassa Virus Reassortants in a Guinea Pig Model.
Welch SR, Scholte FEM, Albariño CG, Kainulainen MH, Coleman-McCray JD, Guerrero LW, Chakrabarti AK, Klena JD, Nichol ST, Spengler JR, Spiropoulou CF
Frontiers in cellular and infection microbiology 2018;8:240
Frontiers in cellular and infection microbiology 2018;8:240
Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1.
Chauché C, Nogales A, Zhu H, Goldfarb D, Ahmad Shanizza AI, Gu Q, Parrish CR, Martínez-Sobrido L, Marshall JF, Murcia PR
Journal of virology 2018 Mar 1;92(5)
Journal of virology 2018 Mar 1;92(5)
ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway.
Yuan H, Zhou W, Yang Y, Xue L, Liu L, Song Y
Experimental cell research 2018 Jun 1;367(1):47-55
Experimental cell research 2018 Jun 1;367(1):47-55
Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.
Alandijany T, Roberts APE, Conn KL, Loney C, McFarlane S, Orr A, Boutell C
PLoS pathogens 2018 Jan;14(1):e1006769
PLoS pathogens 2018 Jan;14(1):e1006769
Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing.
Bianco C, Mohr I
Journal of virology 2017 May 1;91(9)
Journal of virology 2017 May 1;91(9)
ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins.
Villarroya-Beltri C, Baixauli F, Mittelbrunn M, Fernández-Delgado I, Torralba D, Moreno-Gonzalo O, Baldanta S, Enrich C, Guerra S, Sánchez-Madrid F
Nature communications 2016 Nov 24;7:13588
Nature communications 2016 Nov 24;7:13588
Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling.
Zeng X, Wang S, Chi X, Chen SL, Huang S, Lin Q, Xie B, Chen JL
Research in veterinary science 2016 Feb;104:40-9
Research in veterinary science 2016 Feb;104:40-9
Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity.
Care MA, Stephenson SJ, Barnes NA, Fan I, Zougman A, El-Sherbiny YM, Vital EM, Westhead DR, Tooze RM, Doody GM
Journal of immunology (Baltimore, Md. : 1950) 2016 Aug 15;197(4):1447-59
Journal of immunology (Baltimore, Md. : 1950) 2016 Aug 15;197(4):1447-59
Differential interferon pathway gene expression patterns in Rhabdomyosarcoma cells during Enterovirus 71 or Coxsackievirus A16 infection.
Zhang W, Zhang L, Wu Z, Tien P
Biochemical and biophysical research communications 2014 May 9;447(3):550-5
Biochemical and biophysical research communications 2014 May 9;447(3):550-5
ISG15 is a critical microenvironmental factor for pancreatic cancer stem cells.
Sainz B Jr, Martín B, Tatari M, Heeschen C, Guerra S
Cancer research 2014 Dec 15;74(24):7309-20
Cancer research 2014 Dec 15;74(24):7309-20
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 15981-1-AP(ISG15 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ISG15 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ISG15. This antibody recognizes human antigen. The ISG15 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
