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- Antigen structure
- References [33]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 10242-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10242-1-AP, RRID:AB_2090144
- Product name
- CYC1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CYC1 antibody (Cat. #10242-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Quantification Quality Control Emerges as a Crucial Factor to Enhance Single-Cell Proteomics Data Analysis.
UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation.
Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas.
Marine Sponge-Derived Alkaloid Induces Mitochondrial Dysfunction and Inhibits the PI3K/AKT/mTOR Signaling Pathway against Burkitt's Lymphoma.
Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out Mouse.
Effect of one-time high load exercise on skeletal muscle injury in rats of different genders: oxidative stress and mitochondrial responses.
Protective effect of low-dose radiation on doxorubicin-induced brain injury in mice.
Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.
Large-leaf yellow tea attenuates high glucose-induced vascular endothelial cell injury by up-regulating autophagy and down-regulating oxidative stress.
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways.
NDUFS3 depletion permits complex I maturation and reveals TMEM126A/OPA7 as an assembly factor binding the ND4-module intermediate.
Fluoride-induced renal dysfunction via respiratory chain complex abnormal expression and fusion elevation in mice.
Mitochondrial respiratory chain damage and mitochondrial fusion disorder are involved in liver dysfunction of fluoride-induced mice.
Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV.
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
Mitochondrial respiratory chain dysfunction mediated by ROS is a primary point of fluoride-induced damage in Hepa1-6 cells.
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
MicroRNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome c1.
Critical role of cytochrome c1 and its cleavage in porcine reproductive and respiratory syndrome virus nonstructural protein 4-induced cell apoptosis via interaction with nsp4.
Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.
The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.
PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.
CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.
Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells.
Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice.
iTRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells.
Quantitative proteomics for cardiac biomarker discovery using isoproterenol-treated nonhuman primates.
Proteomic analysis of mitochondria from infantile hemangioma endothelial cells treated with sodium morrhuate and its liposomal formulation.
Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release.
An integrative multi-platform analysis for discovering biomarkers of osteosarcoma.
A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice.
Adaptor FADD is recruited by RTN3/HAP in ER-bound signaling complexes.
Yu SH, Chen SC, Wu PS, Kuo PI, Chen TA, Lee HY, Lin MH
Molecular & cellular proteomics : MCP 2024 May;23(5):100768
Molecular & cellular proteomics : MCP 2024 May;23(5):100768
UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation.
Ahlstedt BA, Ganji R, Mukkavalli S, Paulo JA, Gygi SP, Raman M
EMBO reports 2024 Feb;25(2):672-703
EMBO reports 2024 Feb;25(2):672-703
Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas.
Gao Y, Long Q, Yang H, Hu Y, Xu Y, Tang C, Gu C, Yong S
Experimental and therapeutic medicine 2023 Nov;26(5):533
Experimental and therapeutic medicine 2023 Nov;26(5):533
Marine Sponge-Derived Alkaloid Induces Mitochondrial Dysfunction and Inhibits the PI3K/AKT/mTOR Signaling Pathway against Burkitt's Lymphoma.
Zhao HM, He J, Chang YT, Liu LY, Sun F, Lin HW, Yang F
Journal of natural products 2023 Jan 27;86(1):45-51
Journal of natural products 2023 Jan 27;86(1):45-51
Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out Mouse.
Lawther AJ, Zieba J, Fang Z, Furlong TM, Conn I, Govindaraju H, Choong LLY, Turner N, Siddiqui KS, Bridge W, Merlin S, Hyams TC, Killingsworth M, Eapen V, Clarke RA, Walker AK
Genes 2023 Aug 28;14(9)
Genes 2023 Aug 28;14(9)
Effect of one-time high load exercise on skeletal muscle injury in rats of different genders: oxidative stress and mitochondrial responses.
Wang Y, Chen M, Gao Y, He K, Yang Z, Li Y, Zhang S, Zhao L
Acta cirurgica brasileira 2022;37(8):e370805
Acta cirurgica brasileira 2022;37(8):e370805
Protective effect of low-dose radiation on doxorubicin-induced brain injury in mice.
Gao Y, Dong J, Chen M, Wang T, Yang Z, He K, Li Y, Wang K, Jiang J, Zhang S
Archives of biochemistry and biophysics 2022 Oct 30;729:109390
Archives of biochemistry and biophysics 2022 Oct 30;729:109390
Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.
Sun LY, Lyu YY, Zhang HY, Shen Z, Lin GQ, Geng N, Wang YL, Huang L, Feng ZH, Guo X, Lin N, Ding S, Yuan AC, Zhang L, Qian K, Pu J
Circulation 2022 Nov 22;146(21):1591-1609
Circulation 2022 Nov 22;146(21):1591-1609
Large-leaf yellow tea attenuates high glucose-induced vascular endothelial cell injury by up-regulating autophagy and down-regulating oxidative stress.
Wang P, Huang Y, Ren J, Rong Y, Fan L, Zhang P, Zhang X, Xi J, Mao S, Su M, Zhang B, Bao G, Wu F
Food & function 2022 Feb 21;13(4):1890-1905
Food & function 2022 Feb 21;13(4):1890-1905
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
Le Vasseur M, Friedman J, Jost M, Xu J, Yamada J, Kampmann M, Horlbeck MA, Salemi MR, Phinney BS, Weissman JS, Nunnari J
eLife 2021 May 26;10
eLife 2021 May 26;10
Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways.
Wang X, Gong Q, Song C, Fang J, Yang Y, Liang X, Huang X, Liu J
Toxicology and applied pharmacology 2021 May 1;418:115484
Toxicology and applied pharmacology 2021 May 1;418:115484
NDUFS3 depletion permits complex I maturation and reveals TMEM126A/OPA7 as an assembly factor binding the ND4-module intermediate.
D'Angelo L, Astro E, De Luise M, Kurelac I, Umesh-Ganesh N, Ding S, Fearnley IM, Gasparre G, Zeviani M, Porcelli AM, Fernandez-Vizarra E, Iommarini L
Cell reports 2021 Apr 20;35(3):109002
Cell reports 2021 Apr 20;35(3):109002
Fluoride-induced renal dysfunction via respiratory chain complex abnormal expression and fusion elevation in mice.
Wang HW, Zhu SQ, Liu J, Miao CY, Zhang Y, Zhou BH
Chemosphere 2020 Jan;238:124607
Chemosphere 2020 Jan;238:124607
Mitochondrial respiratory chain damage and mitochondrial fusion disorder are involved in liver dysfunction of fluoride-induced mice.
Wang HW, Liu J, Wei SS, Zhao WP, Zhu SQ, Zhou BH
Chemosphere 2020 Feb;241:125099
Chemosphere 2020 Feb;241:125099
Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV.
Protasoni M, Pérez-Pérez R, Lobo-Jarne T, Harbour ME, Ding S, Peñas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernández-Vizarra E
The EMBO journal 2020 Feb 3;39(3):e102817
The EMBO journal 2020 Feb 3;39(3):e102817
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
Maio N, Kim KS, Holmes-Hampton G, Singh A, Rouault TA
Haematologica 2019 Sep;104(9):1756-1767
Haematologica 2019 Sep;104(9):1756-1767
Mitochondrial respiratory chain dysfunction mediated by ROS is a primary point of fluoride-induced damage in Hepa1-6 cells.
Wang HW, Zhang Y, Tan PP, Jia LS, Chen Y, Zhou BH
Environmental pollution (Barking, Essex : 1987) 2019 Dec;255(Pt 3):113359
Environmental pollution (Barking, Essex : 1987) 2019 Dec;255(Pt 3):113359
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Liu L, Sun Y, Zhao Y, Wang Q, Guo H, Guo R, Liu Y, Fu S, Zhang L, Li Y, Meng Y
Cancer science 2018 Dec;109(12):3762-3773
Cancer science 2018 Dec;109(12):3762-3773
MicroRNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome c1.
Fan L, Zhu C, Qiu R, Zan P, Zheng Z, Xu T, Li G
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(5):1935-1946
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(5):1935-1946
Critical role of cytochrome c1 and its cleavage in porcine reproductive and respiratory syndrome virus nonstructural protein 4-induced cell apoptosis via interaction with nsp4.
Zhang F, Gao P, Ge XN, Zhou L, Guo X, Yang HC
Journal of integrative agriculture : JIA 2017 Nov;16(11):2573-2585
Journal of integrative agriculture : JIA 2017 Nov;16(11):2573-2585
Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.
Fu L, Xu Y, Hou Y, Qi X, Zhou L, Liu H, Luan Y, Jing L, Miao Y, Zhao S, Liu H, Li X
Scientific reports 2017 Mar 27;7:45291
Scientific reports 2017 Mar 27;7:45291
The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.
Lian X, Zhao J, Wu X, Zhang Y, Li Q, Lin S, Bai XY, Chen X
Biochemical and biophysical research communications 2017 Jun 24;488(2):374-381
Biochemical and biophysical research communications 2017 Jun 24;488(2):374-381
PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.
Saita S, Nolte H, Fiedler KU, Kashkar H, Venne AS, Zahedi RP, Krüger M, Langer T
Nature cell biology 2017 Apr;19(4):318-328
Nature cell biology 2017 Apr;19(4):318-328
CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.
Han Y, Sun S, Zhao M, Zhang Z, Gong S, Gao P, Liu J, Zhou J, Ma D, Gao Q, Wu P
Disease markers 2016;2016:3528064
Disease markers 2016;2016:3528064
Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells.
Sun S, Han Y, Liu J, Fang Y, Tian Y, Zhou J, Ma D, Wu P
PloS one 2014;9(3):e91610
PloS one 2014;9(3):e91610
Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice.
Bharadwaj MS, Zhou Y, Molina AJ, Criswell T, Lu B
Redox biology 2014;2:1008-15
Redox biology 2014;2:1008-15
iTRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells.
Chen H, Xu L, Yin L, Xu Y, Han X, Qi Y, Zhao Y, Liu K, Peng J
Proteomics 2014 Jan;14(1):51-73
Proteomics 2014 Jan;14(1):51-73
Quantitative proteomics for cardiac biomarker discovery using isoproterenol-treated nonhuman primates.
Song B, Liu Y, Parman T, Liu S, Miller JK, Liu X, Tanga MJ, Mirsalis J
Journal of proteome research 2014 Dec 5;13(12):5909-17
Journal of proteome research 2014 Dec 5;13(12):5909-17
Proteomic analysis of mitochondria from infantile hemangioma endothelial cells treated with sodium morrhuate and its liposomal formulation.
Tu JB, Dong Q, Hu XY, Jiang F, Ma RZ, He LY, Yang ZQ
Journal of biochemical and molecular toxicology 2012 Sep;26(9):374-80
Journal of biochemical and molecular toxicology 2012 Sep;26(9):374-80
Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release.
Zhu Y, Li M, Wang X, Jin H, Liu S, Xu J, Chen Q
Cell research 2012 Jan;22(1):127-41
Cell research 2012 Jan;22(1):127-41
An integrative multi-platform analysis for discovering biomarkers of osteosarcoma.
Li G, Zhang W, Zeng H, Chen L, Wang W, Liu J, Zhang Z, Cai Z
BMC cancer 2009 May 16;9:150
BMC cancer 2009 May 16;9:150
A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice.
Lu B, Poirier C, Gaspar T, Gratzke C, Harrison W, Busija D, Matzuk MM, Andersson KE, Overbeek PA, Bishop CE
Biology of reproduction 2008 Apr;78(4):601-10
Biology of reproduction 2008 Apr;78(4):601-10
Adaptor FADD is recruited by RTN3/HAP in ER-bound signaling complexes.
Xiang R, Liu Y, Zhu L, Dong W, Qi Y
Apoptosis : an international journal on programmed cell death 2006 Nov;11(11):1923-32
Apoptosis : an international journal on programmed cell death 2006 Nov;11(11):1923-32
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 10242-1-AP(CYC1 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 10242-1-AP(CYC1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CYC1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CYC1. This antibody recognizes human, mouse, rat antigen. The CYC1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
