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- References [12]
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- Western blot [1]
- ELISA [1]
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- Product number
- H00004077-M01 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#H00004077-M01, RRID:AB_1146347
- Product name
- Mouse Monoclonal NBR1 Antibody
- Antibody type
- Monoclonal
- Description
- IgG purified. NBR1 - neighbor of BRCA1 gene 1 (6B11)
- Reactivity
- Human, Mouse
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references Selective autophagy of cytosolic protein aggregates involves ribosome-free rough endoplasmic reticulum.
Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk.
Peroxin Pex14p is the key component for coordinated autophagic degradation of mammalian peroxisomes by direct binding to LC3-II.
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Phosphorylation of NBR1 by GSK3 modulates protein aggregation.
ERADication of EDEM1 occurs by selective autophagy and requires deglycosylation by cytoplasmic peptide N-glycanase.
Lysosomal membrane permeability stimulates protein aggregate formation in neurons of a lysosomal disease.
NBR1 acts as an autophagy receptor for peroxisomes.
Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease.
Molecular determinants of selective clearance of protein inclusions by autophagy.
Nbr1 is a novel inhibitor of ligand-mediated receptor tyrosine kinase degradation.
Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling.
Park S, Zuber C, Roth J
Histochemistry and cell biology 2020 Feb;153(2):89-99
Histochemistry and cell biology 2020 Feb;153(2):89-99
Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk.
Cai J, Pires KM, Ferhat M, Chaurasia B, Buffolo MA, Smalling R, Sargsyan A, Atkinson DL, Summers SA, Graham TE, Boudina S
Cell reports 2018 Nov 13;25(7):1708-1717.e5
Cell reports 2018 Nov 13;25(7):1708-1717.e5
Peroxin Pex14p is the key component for coordinated autophagic degradation of mammalian peroxisomes by direct binding to LC3-II.
Jiang L, Hara-Kuge S, Yamashita S, Fujiki Y
Genes to cells : devoted to molecular & cellular mechanisms 2015 Jan;20(1):36-49
Genes to cells : devoted to molecular & cellular mechanisms 2015 Jan;20(1):36-49
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D'Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO
Nature cell biology 2014 Nov;16(11):1069-79
Nature cell biology 2014 Nov;16(11):1069-79
Phosphorylation of NBR1 by GSK3 modulates protein aggregation.
Nicot AS, Lo Verso F, Ratti F, Pilot-Storck F, Streichenberger N, Sandri M, Schaeffer L, Goillot E
Autophagy 2014 Jun;10(6):1036-53
Autophagy 2014 Jun;10(6):1036-53
ERADication of EDEM1 occurs by selective autophagy and requires deglycosylation by cytoplasmic peptide N-glycanase.
Park S, Jang I, Zuber C, Lee Y, Cho JW, Matsuo I, Ito Y, Roth J
Histochemistry and cell biology 2014 Aug;142(2):153-69
Histochemistry and cell biology 2014 Aug;142(2):153-69
Lysosomal membrane permeability stimulates protein aggregate formation in neurons of a lysosomal disease.
Micsenyi MC, Sikora J, Stephney G, Dobrenis K, Walkley SU
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Jun 26;33(26):10815-27
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Jun 26;33(26):10815-27
NBR1 acts as an autophagy receptor for peroxisomes.
Deosaran E, Larsen KB, Hua R, Sargent G, Wang Y, Kim S, Lamark T, Jauregui M, Law K, Lippincott-Schwartz J, Brech A, Johansen T, Kim PK
Journal of cell science 2013 Feb 15;126(Pt 4):939-52
Journal of cell science 2013 Feb 15;126(Pt 4):939-52
Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease.
Rué L, López-Soop G, Gelpi E, Martínez-Vicente M, Alberch J, Pérez-Navarro E
Neurobiology of disease 2013 Apr;52:219-28
Neurobiology of disease 2013 Apr;52:219-28
Molecular determinants of selective clearance of protein inclusions by autophagy.
Wong E, Bejarano E, Rakshit M, Lee K, Hanson HH, Zaarur N, Phillips GR, Sherman MY, Cuervo AM
Nature communications 2012;3:1240
Nature communications 2012;3:1240
Nbr1 is a novel inhibitor of ligand-mediated receptor tyrosine kinase degradation.
Mardakheh FK, Auciello G, Dafforn TR, Rappoport JZ, Heath JK
Molecular and cellular biology 2010 Dec;30(24):5672-85
Molecular and cellular biology 2010 Dec;30(24):5672-85
Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling.
Mardakheh FK, Yekezare M, Machesky LM, Heath JK
The Journal of cell biology 2009 Oct 19;187(2):265-77
The Journal of cell biology 2009 Oct 19;187(2):265-77
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: NBR1 Antibody (6B11) [H00004077-M01] - Western Blot analysis of NBR1 expression in PC-12
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- ELISA: NBR1 Antibody (6B11) [H00004077-M01] - Detection limit for recombinant GST tagged NBR1 is approximately 0.1ng/ml as a capture antibody.
