Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 19925-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19925-1-AP, RRID:AB_10666166
- Product name
- TMEM175 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TMEM175 antibody (Cat. #19925-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Deficiency of lysosomal TMEM175 in myeloid macrophages exerts anti-tumor immunity via inflammasome and cross-presentation pathway.
SiO(2) NP promotes allergic gastritis induced by degranulation of mouse MC9 cell through AQP4-mediated impairment of SIRT3-TFAM deacetylation and mitochondrial autophagy.
Structural insights into the activation of TMEM175 by small molecule.
Endolysosomal channel TMEM175 mediates antitoxin activity of DABMA.
TMEM175 plays a crucial role in osteoblast differentiation by regulating lysosomal function and autophagy.
Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.
Resveratrol attenuates inflammation and fibrosis in rheumatoid arthritis-associated interstitial lung disease via the AKT/TMEM175 pathway.
Modulation of anti-cardiac fibrosis immune responses by changing M2 macrophages into M1 macrophages.
Patient-derived Induced Pluripotent Stem Cells as a Model to Study Frontotemporal Dementia Pathologies.
Characterization of the role of TMEM175 in an in vitro lysosomal H(+) fluxes model.
TMEM175 downregulation participates in impairment of the autophagy related lysosomal dynamics following neonatal hypoxic-ischemic brain injury.
Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
A Comparative Study on the Lysosomal Cation Channel TMEM175 Using Automated Whole-Cell Patch-Clamp, Lysosomal Patch-Clamp, and Solid Supported Membrane-Based Electrophysiology: Functional Characterization and High-Throughput Screening Assay Development.
Common and Rare Variants in TMEM175 Gene Concur to the Pathogenesis of Parkinson's Disease in Italian Patients.
Lysosomal K(+) channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease.
A growth-factor-activated lysosomal K(+) channel regulates Parkinson's pathology.
Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies.
TMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion.
Functionalization of the TMEM175 p.M393T variant as a risk factor for Parkinson disease.
Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts.
TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.
TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function.
Zhang Z, Li X, Lu T, Yang J, Han X, Bi Z, Luo J, Alu A, Hong W, Chen S, Chen L, Cheng Y, He X, Zhu C, Wang M, Li Q, Wang Y, Li L, Lei H, Lan J, Geng J, Wei Y, Wei X
Nature communications 2026 Feb 14;17(1)
Nature communications 2026 Feb 14;17(1)
SiO(2) NP promotes allergic gastritis induced by degranulation of mouse MC9 cell through AQP4-mediated impairment of SIRT3-TFAM deacetylation and mitochondrial autophagy.
Lei Y, Wang X, Wu H, Gao M, Xu T, Lin H
Journal of hazardous materials 2025 Oct 5;497:139721
Journal of hazardous materials 2025 Oct 5;497:139721
Structural insights into the activation of TMEM175 by small molecule.
Zhu X, Ping M, Liu H, Yu T, Jiang Z, Liu Z, Li C, Hou X, Chu Q, Li S, Mao C, Luo T, Kang C, Wang F, Yang C, Tang M, Jiang Z, Gao Z, Liu H, Xu HE, Tang B, Cheng X, Yin W, Zhou Y, Li P
Neuron 2025 Nov 5;113(21):3567-3581.e9
Neuron 2025 Nov 5;113(21):3567-3581.e9
Endolysosomal channel TMEM175 mediates antitoxin activity of DABMA.
Wu Y, Huang J, Zhang F, Guivel-Benhassine F, Hubert M, Schwartz O, Xiao W, Cintrat JC, Qu L, Barbier J, Gillet D, Cang C
The FEBS journal 2024 Sep;291(18):4142-4154
The FEBS journal 2024 Sep;291(18):4142-4154
TMEM175 plays a crucial role in osteoblast differentiation by regulating lysosomal function and autophagy.
Lee SH, Jang JS, Mo S, Kim HH
Molecules and cells 2024 Nov;47(11):100127
Molecules and cells 2024 Nov;47(11):100127
Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.
Wang Y, Yang Y, Cai Y, Aobulikasimu A, Wang Y, Hu C, Miao Z, Shao Y, Zhao M, Hu Y, Xu C, Chen X, Li Z, Chen J, Wang L, Chen S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709
Resveratrol attenuates inflammation and fibrosis in rheumatoid arthritis-associated interstitial lung disease via the AKT/TMEM175 pathway.
Liu N, Fan X, Shao Y, Chen S, Wang T, Yao T, Chen X
Journal of translational medicine 2024 May 14;22(1):457
Journal of translational medicine 2024 May 14;22(1):457
Modulation of anti-cardiac fibrosis immune responses by changing M2 macrophages into M1 macrophages.
Chen S, Wang K, Fan Z, Zhou T, Li R, Zhang B, Chen J, Chi J, Wei K, Liu J, Liu Z, Ma J, Dong N, Liu J
Molecular medicine (Cambridge, Mass.) 2024 Jun 15;30(1):88
Molecular medicine (Cambridge, Mass.) 2024 Jun 15;30(1):88
Patient-derived Induced Pluripotent Stem Cells as a Model to Study Frontotemporal Dementia Pathologies.
Infante-Tadeo S, Barber DL
bioRxiv : the preprint server for biology 2024 Dec 17;
bioRxiv : the preprint server for biology 2024 Dec 17;
Characterization of the role of TMEM175 in an in vitro lysosomal H(+) fluxes model.
Yang C, Tian F, Hu M, Kang C, Ping M, Liu Y, Hu M, Xu H, Yu Y, Gao Z, Li P
The FEBS journal 2023 Oct;290(19):4641-4659
The FEBS journal 2023 Oct;290(19):4641-4659
TMEM175 downregulation participates in impairment of the autophagy related lysosomal dynamics following neonatal hypoxic-ischemic brain injury.
Zhang H, Tian Y, Yu W, Tong D, Ji Y, Qu X, Deng T, Li X, Xu Y
Journal of cellular physiology 2023 Oct;238(10):2512-2527
Journal of cellular physiology 2023 Oct;238(10):2512-2527
Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Zhang J, Zeng W, Han Y, Lee WR, Liou J, Jiang Y
Molecular cell 2023 Jul 20;83(14):2524-2539.e7
Molecular cell 2023 Jul 20;83(14):2524-2539.e7
A Comparative Study on the Lysosomal Cation Channel TMEM175 Using Automated Whole-Cell Patch-Clamp, Lysosomal Patch-Clamp, and Solid Supported Membrane-Based Electrophysiology: Functional Characterization and High-Throughput Screening Assay Development.
Bazzone A, Barthmes M, George C, Brinkwirth N, Zerlotti R, Prinz V, Cole K, Friis S, Dickson A, Rice S, Lim J, Fern Toh M, Mohammadi M, Pau D, Stone DJ, Renger JJ, Fertig N
International journal of molecular sciences 2023 Aug 14;24(16)
International journal of molecular sciences 2023 Aug 14;24(16)
Common and Rare Variants in TMEM175 Gene Concur to the Pathogenesis of Parkinson's Disease in Italian Patients.
Palomba NP, Fortunato G, Pepe G, Modugno N, Pietracupa S, Damiano I, Mascio G, Carrillo F, Di Giovannantonio LG, Ianiro L, Martinello K, Volpato V, Desiato V, Acri R, Storto M, Nicoletti F, Webber C, Simeone A, Fucile S, Maglione V, Esposito T
Molecular neurobiology 2023 Apr;60(4):2150-2173
Molecular neurobiology 2023 Apr;60(4):2150-2173
Lysosomal K(+) channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease.
Qu L, Lin B, Zeng W, Fan C, Wu H, Ge Y, Li Q, Li C, Wei Y, Xin J, Wang X, Liu D, Cang C
EMBO reports 2022 Sep 5;23(9):e53234
EMBO reports 2022 Sep 5;23(9):e53234
A growth-factor-activated lysosomal K(+) channel regulates Parkinson's pathology.
Wie J, Liu Z, Song H, Tropea TF, Yang L, Wang H, Liang Y, Cang C, Aranda K, Lohmann J, Yang J, Lu B, Chen-Plotkin AS, Luk KC, Ren D
Nature 2021 Mar;591(7850):431-437
Nature 2021 Mar;591(7850):431-437
Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies.
Krohn L, Öztürk TN, Vanderperre B, Ouled Amar Bencheikh B, Ruskey JA, Laurent SB, Spiegelman D, Postuma RB, Arnulf I, Hu MTM, Dauvilliers Y, Högl B, Stefani A, Monaca CC, Plazzi G, Antelmi E, Ferini-Strambi L, Heidbreder A, Rudakou U, Cochen De Cock V, Young P, Wolf P, Oliva P, Zhang XK, Greenbaum L, Liong C, Gagnon JF, Desautels A, Hassin-Baer S, Montplaisir JY, Dupré N, Rouleau GA, Fon EA, Trempe JF, Lamoureux G, Alcalay RN, Gan-Or Z
Annals of neurology 2020 Jan;87(1):139-153
Annals of neurology 2020 Jan;87(1):139-153
TMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion.
Zhang M, Lu H, Xie X, Shen H, Li X, Zhang Y, Wu J, Ni J, Li H, Chen G
Molecular brain 2020 Aug 15;13(1):113
Molecular brain 2020 Aug 15;13(1):113
Functionalization of the TMEM175 p.M393T variant as a risk factor for Parkinson disease.
Jinn S, Blauwendraat C, Toolan D, Gretzula CA, Drolet RE, Smith S, Nalls MA, Marcus J, Singleton AB, Stone DJ
Human molecular genetics 2019 Oct 1;28(19):3244-3254
Human molecular genetics 2019 Oct 1;28(19):3244-3254
Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts.
Korecka JA, Thomas R, Christensen DP, Hinrich AJ, Ferrari EJ, Levy SA, Hastings ML, Hallett PJ, Isacson O
Human molecular genetics 2019 Oct 1;28(19):3232-3243
Human molecular genetics 2019 Oct 1;28(19):3232-3243
TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.
Jinn S, Drolet RE, Cramer PE, Wong AH, Toolan DM, Gretzula CA, Voleti B, Vassileva G, Disa J, Tadin-Strapps M, Stone DJ
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 28;114(9):2389-2394
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 28;114(9):2389-2394
TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function.
Cang C, Aranda K, Seo YJ, Gasnier B, Ren D
Cell 2015 Aug 27;162(5):1101-12
Cell 2015 Aug 27;162(5):1101-12
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TMEM175 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TMEM175. This antibody recognizes human,mouse,rat antigen. The TMEM175 antibody has been validated for the following applications: ELISA, WB analysis.
