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Learn16451-1-AP
antibody from Proteintech Group
Targeting: MCM8
C20orf154, dJ967N21.5, MGC119522, MGC119523, MGC12866, MGC4816, REC
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ELISAAntibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 16451-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16451-1-AP, RRID:AB_2142833
- Product name
- MCM8 antibody
- Antibody type
- Polyclonal
- Description
- MCM8 antibody (Cat. #16451-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mechanism of DNA unwinding by MCM8-9 in complex with HROB.
Mechanism of DNA unwinding by hexameric MCM8-9 in complex with HROB.
REC drives recombination to repair double-strand breaks in animal mtDNA.
A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress.
MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.
Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8-MCM9 complex and compromises DNA mismatch repair in cancer cells.
DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain.
Acharya A, Bret H, Huang JW, Mütze M, Göse M, Kissling VM, Seidel R, Ciccia A, Guérois R, Cejka P
Nature communications 2024 Apr 27;15(1):3584
Nature communications 2024 Apr 27;15(1):3584
Mechanism of DNA unwinding by hexameric MCM8-9 in complex with HROB.
Acharya A, Bret H, Huang JW, Mütze M, Göse M, Kissling V, Seidel R, Ciccia A, Guérois R, Cejka P
Research square 2023 Jun 26;
Research square 2023 Jun 26;
REC drives recombination to repair double-strand breaks in animal mtDNA.
Klucnika A, Mu P, Jezek J, McCormack M, Di Y, Bradshaw CR, Ma H
The Journal of cell biology 2023 Jan 2;222(1)
The Journal of cell biology 2023 Jan 2;222(1)
A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress.
Griffin WC, McKinzey DR, Klinzing KN, Baratam R, Eliyapura A, Trakselis MA
Nature communications 2022 Aug 30;13(1):5090
Nature communications 2022 Aug 30;13(1):5090
MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.
Huang JW, Acharya A, Taglialatela A, Nambiar TS, Cuella-Martin R, Leuzzi G, Hayward SB, Joseph SA, Brunette GJ, Anand R, Soni RK, Clark NL, Bernstein KA, Cejka P, Ciccia A
Nature communications 2020 Jun 11;11(1):2948
Nature communications 2020 Jun 11;11(1):2948
Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8-MCM9 complex and compromises DNA mismatch repair in cancer cells.
Liu K, Wang Y, Zhu Q, Li P, Chen J, Tang Z, Shen Y, Cheng X, Lu LY, Liu Y
Cell death & disease 2020 Jul 9;11(7):519
Cell death & disease 2020 Jul 9;11(7):519
DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain.
Zhang J, Bellani MA, James RC, Pokharel D, Zhang Y, Reynolds JJ, McNee GS, Jackson AP, Stewart GS, Seidman MM
Nature communications 2020 Aug 7;11(1):3951
Nature communications 2020 Aug 7;11(1):3951
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MCM8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MCM8. This antibody recognizes human, mouse, rat antigen. The MCM8 antibody has been validated for the following applications: ELISA, WB analysis.
