Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-L1579 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Rabbit Anti-Human MSK1 monoclonal antibody, clone 5I26M62
- Antibody type
- Monoclonal
- Description
- MSK-1 is a mitogen and stress activated protein kinase-1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK-1 can be activated by ERK1/2 and SAPK2 /p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG-14 in response to mitogen and stress. Similar to RSK, MSK-1 contains two kinase domains (N-term and a C-term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK-1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C-terminal kinase domain of MSK-1 which is essential for the catalytic activity of the N-terminal kinase domain.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 5I26M62
- Concentration
- 0.5 mg/ml
- Storage
- -20°C, Avoid Freeze/Thaw Cycles
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