28363-1-AP

antibody from Proteintech Group

Targeting: MAEA EMP, GID9, HLC-10, p44EMLP

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

28363-1-AP

Provider

Proteintech Group

Product name

MAEA antibody

Antibody type

Polyclonal

Description

MAEA antibody (Cat. #28363-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis.

Grant DW, Tan S, Ramage DE, Li MZ, Di Y, Tchasovnikarova IA, Weekes MP, Elledge SJ, Warren AJ, Timms RT
bioRxiv : the preprint server for biology 2026 Jan 14;

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The E3 ubiquitin ligase MAEA promotes macrophage phagocytosis and inhibits gastrointestinal cancer progression by mediating PARP1 ubiquitination and degradation.

Feng Y, Zou X, Huang J, Huang Z, Kuang G, Jiang Y
International journal of biological sciences 2025;21(4):1784-1800

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mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase.

Pham BQ, Yi SA, Ordureau A, An H
Cell reports 2025 Jan 28;44(1):115179

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mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway.

Yi SA, Sepic S, Schulman BA, Ordureau A, An H
Molecular cell 2024 Jun 6;84(11):2166-2184.e9

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LAD1 promotes malignant progression by diminishing ubiquitin-dependent degradation of vimentin in gastric cancer.

Jiang Y, Feng Y, Huang J, Huang Z, Tan R, Li T, Chen Z, Tang X, Qiu J, Li C, Chen H, Yang Z
Journal of translational medicine 2023 Sep 17;21(1):632

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Identifying E3 Ligase Substrates With Quantitative Degradation Proteomics.

Jordan VN, Ordureau A, An H
Chembiochem : a European journal of chemical biology 2023 Aug 15;24(16):e202300108

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E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression.

Zhou P, Peng X, Tang S, Zhang K, Tan Z, Li D, Shen L, Peng J, Yang L
Oncogene 2023 Apr;42(16):1308-1320

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Oncopeptide MBOP Encoded by LINC01234 Promotes Colorectal Cancer through MAPK Signaling Pathway.

Tang C, Zhou Y, Sun W, Hu H, Liu Y, Chen L, Ou F, Zeng S, Lin N, Yu L
Cancers 2022 May 9;14(9)