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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [76]
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- Western blot [2]
- Immunohistochemistry [9]
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- Product number
- NB100-131 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-131, RRID:AB_10080940
- Product name
- Mouse Monoclonal HIF-1 alpha Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified.
- Reactivity
- Human, Mouse, Rat, Bovine, Canine
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references G3BP1-linked mRNA partitioning supports selective protein synthesis in response to oxidative stress.
Neuregulin-1 Protects Neuronal Cells Against Damage due to CoCl2-Induced Hypoxia by Suppressing Hypoxia-Inducible Factor-1α and P53 in SH-SY5Y Cells.
Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats.
Lung Carcinoids: Long-Term Surgical Results and the Lack of Prognostic Value of Somatostatin Receptors and Other Novel Immunohistochemical Markers.
LOX-catalyzed collagen stabilization is a proximal cause for intrinsic resistance to chemotherapy.
Hemostatic nanoparticles increase survival, mitigate neuropathology and alleviate anxiety in a rodent blast trauma model.
Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance.
Can insulin-like growth factor 1 (IGF-1), IGF-1 receptor connective tissue growth factor and Ki-67 labelling index have a prognostic role in pulmonary carcinoids?
Markers of oxidative/nitrosative stress and inflammation in lung tissue of rats exposed to different intravenous iron compounds.
EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1.
Fibrin-associated EBV-positive Large B-Cell Lymphoma: An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation.
Functional and anatomical evidence of cerebral tissue hypoxia in young sickle cell anemia mice.
Cutaneous exposure to hypoxia does not affect skin perfusion in humans.
EPR Oximetry of Cetuximab-Treated Head-and-Neck Tumours in a Mouse Model.
Effect of early administration of lower dose versus high dose of fresh mitochondria on reducing monocrotaline-induced pulmonary artery hypertension in rat.
Increased Vascularization in the Vulnerable Upstream Regions of Both Early and Advanced Human Carotid Atherosclerosis.
EML4-ALK enhances programmed cell death-ligand 1 expression in pulmonary adenocarcinoma via hypoxia-inducible factor (HIF)-1α and STAT3.
Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis.
Dicer suppresses the malignant phenotype in VHL-deficient clear cell renal cell carcinoma by inhibiting HIF-2α.
Use of the Reamer/Irrigator/Aspirator Decreases Carotid and Cranial Embolic Events in a Canine Model.
Carbonic Anhydrase XII as an Independent Prognostic Factor in Advanced Esophageal Squamous Cell Carcinoma.
Systemic and Cerebral Vascular Endothelial Growth Factor Levels Increase in Murine Cerebral Malaria along with Increased Calpain and Caspase Activity and Can be Reduced by Erythropoietin Treatment.
Biochemical and immunomorphological evaluation of hepatocyte growth factor and c-Met pathway in patients with critical limb ischemia.
2-Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF-1α response after traumatic brain injury in mice.
TGF-β/Smad3 inhibit vascular smooth muscle cell apoptosis through an autocrine signaling mechanism involving VEGF-A.
CTGF is a therapeutic target for metastatic melanoma.
High tumor cell expression of microRNA-21 in node positive non-small cell lung cancer predicts a favorable clinical outcome.
Sporadic hemangioblastomas are characterized by cryptic VHL inactivation.
Treatment with a highly selective β₁ antagonist causes dose-dependent impairment of cerebral perfusion after hemodilution in rats.
Early histopathologic changes in the retina and optic nerve in canine primary angle-closure glaucoma.
Tissue hypoxia in pathogenesis of ulcerative colitis: should we change all our beliefs?
BOLD-MRI of breast invasive ductal carcinoma: correlation of R2* value and the expression of HIF-1α.
Prognostic assessment of hypoxia and metabolic markers in cervical cancer using automated digital image analysis of immunohistochemistry.
p16, Cyclin D1, and HIF-1α Predict Outcomes of Patients with Oropharyngeal Squamous Cell Carcinoma Treated with Definitive Intensity-Modulated Radiation Therapy.
Prognostic impacts of hypoxic markers in soft tissue sarcoma.
An improved method for the study of apoptosis-related genes using the tet-on system.
Diverging prognostic impacts of hypoxic markers according to NSCLC histology.
Coexpression of hypoxia-inducible factor-1α and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients.
Loss of epidermal hypoxia-inducible factor-1α accelerates epidermal aging and affects re-epithelialization in human and mouse.
Hypoxia-induced overexpression of BNIP3 is not dependent on hypoxia-inducible factor 1α in mouse hepatocytes.
Prognostic implications of hypoxia-inducible factor-1α in epidermal growth factor receptor-negative non-small cell lung cancer.
Low-dose radiation augments vasculogenesis signaling through HIF-1-dependent and -independent SDF-1 induction.
Hypoxia stimulates CXCR4 signalling in ileal carcinoids.
Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.
Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration.
Metoprolol reduces cerebral tissue oxygen tension after acute hemodilution in rats.
Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis.
Hypoxia inducible factor-1alpha correlates with vascular endothelial growth factor A and C indicating worse prognosis in clear cell renal cell carcinoma.
Antitumor activity of an oncolytic adenoviral-CD40 ligand (CD154) transgene construct in human breast cancer cells.
Hypoxia inducible factor-1 alpha activation of the JCV promoter: role in the pathogenesis of progressive multifocal leukoencephalopathy.
Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma.
Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma.
Expression of hypoxia-inducible factor 1alpha gene affects the outcome in patients with ovarian cancer.
Expression of hypoxia-inducible factor-1alpha and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours.
Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores.
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia.
p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury.
In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy.
Differential regulation of hypoxia-induced CXCR4 triggering during B-cell development and lymphomagenesis.
Over-expression of hypoxia-inducible factor 1 alpha in ovarian clear cell carcinoma.
Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands.
In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfate.
CoCl2-induced HIF-1alpha expression correlates with proliferation and apoptosis in MKN-1 cells: a possible role for the PI3K/Akt pathway.
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.
Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors.
Hypoxia at the site of abdominal aortic aneurysm rupture is not associated with increased lactate.
Hypoxia-inducible factor 1alpha expression in renal cell carcinoma analyzed by tissue microarray.
Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1alpha in non-small cell lung cancers.
Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe?
Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe?
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.
Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer.
Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy.
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
Somasekharan SP, Zhang F, Saxena N, Huang JN, Kuo IC, Low C, Bell R, Adomat H, Stoynov N, Foster L, Gleave M, Sorensen PH
Nucleic acids research 2020 Jul 9;48(12):6855-6873
Nucleic acids research 2020 Jul 9;48(12):6855-6873
Neuregulin-1 Protects Neuronal Cells Against Damage due to CoCl2-Induced Hypoxia by Suppressing Hypoxia-Inducible Factor-1α and P53 in SH-SY5Y Cells.
Yoo SY, Yoo JY, Kim HB, Baik TK, Lee JH, Woo RS
International neurourology journal 2019 Nov;23(Suppl 2):S111-118
International neurourology journal 2019 Nov;23(Suppl 2):S111-118
Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats.
Otsuka S, Sakakima H, Terashi T, Takada S, Nakanishi K, Kikuchi K
Brain structure & function 2019 Mar;224(2):727-738
Brain structure & function 2019 Mar;224(2):727-738
Lung Carcinoids: Long-Term Surgical Results and the Lack of Prognostic Value of Somatostatin Receptors and Other Novel Immunohistochemical Markers.
Daskalakis K, Kaltsas G, Öberg K, Tsolakis AV
Neuroendocrinology 2018;107(4):355-365
Neuroendocrinology 2018;107(4):355-365
LOX-catalyzed collagen stabilization is a proximal cause for intrinsic resistance to chemotherapy.
Rossow L, Veitl S, Vorlová S, Wax JK, Kuhn AE, Maltzahn V, Upcin B, Karl F, Hoffmann H, Gätzner S, Kallius M, Nandigama R, Scheld D, Irmak S, Herterich S, Zernecke A, Ergün S, Henke E
Oncogene 2018 Sep;37(36):4921-4940
Oncogene 2018 Sep;37(36):4921-4940
Hemostatic nanoparticles increase survival, mitigate neuropathology and alleviate anxiety in a rodent blast trauma model.
Hubbard WB, Lashof-Sullivan M, Greenberg S, Norris C, Eck J, Lavik E, VandeVord P
Scientific reports 2018 Jul 13;8(1):10622
Scientific reports 2018 Jul 13;8(1):10622
Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance.
Song KH, Kim JH, Lee YH, Bae HC, Lee HJ, Woo SR, Oh SJ, Lee KM, Yee C, Kim BW, Cho H, Chung EJ, Chung JY, Hewitt SM, Chung TW, Ha KT, Bae YK, Mao CP, Yang A, Wu TC, Kim TW
The Journal of clinical investigation 2018 Aug 31;128(9):4098-4114
The Journal of clinical investigation 2018 Aug 31;128(9):4098-4114
Can insulin-like growth factor 1 (IGF-1), IGF-1 receptor connective tissue growth factor and Ki-67 labelling index have a prognostic role in pulmonary carcinoids?
Kanakis GA, Grimelius L, Papaioannou D, Kaltsas G, Tsolakis AV
Oncotarget 2018 Apr 27;9(32):22653-22664
Oncotarget 2018 Apr 27;9(32):22653-22664
Markers of oxidative/nitrosative stress and inflammation in lung tissue of rats exposed to different intravenous iron compounds.
Toblli JE, Cao G, Giani JF, Dominici FP, Angerosa M
Drug design, development and therapy 2017;11:2251-2263
Drug design, development and therapy 2017;11:2251-2263
EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1.
Jayabal P, Houghton PJ, Shiio Y
Genes & cancer 2017 Nov;8(11-12):762-770
Genes & cancer 2017 Nov;8(11-12):762-770
Fibrin-associated EBV-positive Large B-Cell Lymphoma: An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation.
Boyer DF, McKelvie PA, de Leval L, Edlefsen KL, Ko YH, Aberman ZA, Kovach AE, Masih A, Nishino HT, Weiss LM, Meeker AK, Nardi V, Palisoc M, Shao L, Pittaluga S, Ferry JA, Harris NL, Sohani AR
The American journal of surgical pathology 2017 Mar;41(3):299-312
The American journal of surgical pathology 2017 Mar;41(3):299-312
Functional and anatomical evidence of cerebral tissue hypoxia in young sickle cell anemia mice.
Cahill LS, Gazdzinski LM, Tsui AK, Zhou YQ, Portnoy S, Liu E, Mazer CD, Hare GM, Kassner A, Sled JG
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2017 Mar;37(3):994-1005
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2017 Mar;37(3):994-1005
Cutaneous exposure to hypoxia does not affect skin perfusion in humans.
Siebenmann C, Keramidas ME, Rundqvist H, Mijwel S, Cowburn AS, Johnson RS, Eiken O
Acta physiologica (Oxford, England) 2017 Jul;220(3):361-369
Acta physiologica (Oxford, England) 2017 Jul;220(3):361-369
EPR Oximetry of Cetuximab-Treated Head-and-Neck Tumours in a Mouse Model.
Gustafsson H, Kale A, Dasu A, Lund A, Edqvist PH, Roberg K
Cell biochemistry and biophysics 2017 Dec;75(3-4):299-309
Cell biochemistry and biophysics 2017 Dec;75(3-4):299-309
Effect of early administration of lower dose versus high dose of fresh mitochondria on reducing monocrotaline-induced pulmonary artery hypertension in rat.
Huang TH, Chung SY, Chua S, Chai HT, Sheu JJ, Chen YL, Chen CH, Chang HW, Tong MS, Sung PH, Sun CK, Lu HI, Yip HK
American journal of translational research 2016;8(12):5151-5168
American journal of translational research 2016;8(12):5151-5168
Increased Vascularization in the Vulnerable Upstream Regions of Both Early and Advanced Human Carotid Atherosclerosis.
Hjelmgren O, Gellerman K, Kjelldahl J, Lindahl P, Bergström GM
PloS one 2016;11(12):e0166918
PloS one 2016;11(12):e0166918
EML4-ALK enhances programmed cell death-ligand 1 expression in pulmonary adenocarcinoma via hypoxia-inducible factor (HIF)-1α and STAT3.
Koh J, Jang JY, Keam B, Kim S, Kim MY, Go H, Kim TM, Kim DW, Kim CW, Jeon YK, Chung DH
Oncoimmunology 2016 Mar;5(3):e1108514
Oncoimmunology 2016 Mar;5(3):e1108514
Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis.
Kim Y, Nam HJ, Lee J, Park DY, Kim C, Yu YS, Kim D, Park SW, Bhin J, Hwang D, Lee H, Koh GY, Baek SH
Nature communications 2016 Jan 13;7:10347
Nature communications 2016 Jan 13;7:10347
Dicer suppresses the malignant phenotype in VHL-deficient clear cell renal cell carcinoma by inhibiting HIF-2α.
Fan Y, Li H, Ma X, Gao Y, Bao X, Du Q, Ma M, Liu K, Yao Y, Huang Q, Zhang Y, Zhang X
Oncotarget 2016 Apr 5;7(14):18280-94
Oncotarget 2016 Apr 5;7(14):18280-94
Use of the Reamer/Irrigator/Aspirator Decreases Carotid and Cranial Embolic Events in a Canine Model.
Miller AN, Deal D, Green J, Houle T, Brown W, Thore C, Stump D, Webb LX
The Journal of bone and joint surgery. American volume 2016 Apr 20;98(8):658-64
The Journal of bone and joint surgery. American volume 2016 Apr 20;98(8):658-64
Carbonic Anhydrase XII as an Independent Prognostic Factor in Advanced Esophageal Squamous Cell Carcinoma.
Ochi F, Shiozaki A, Ichikawa D, Fujiwara H, Nakashima S, Takemoto K, Kosuga T, Konishi H, Komatsu S, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E
Journal of Cancer 2015;6(10):922-9
Journal of Cancer 2015;6(10):922-9
Systemic and Cerebral Vascular Endothelial Growth Factor Levels Increase in Murine Cerebral Malaria along with Increased Calpain and Caspase Activity and Can be Reduced by Erythropoietin Treatment.
Hempel C, Hoyer N, Kildemoes A, Jendresen CB, Kurtzhals JA
Frontiers in immunology 2014;5:291
Frontiers in immunology 2014;5:291
Biochemical and immunomorphological evaluation of hepatocyte growth factor and c-Met pathway in patients with critical limb ischemia.
Vasuri F, Fittipaldi S, Abualhin M, Degiovanni A, Gargiulo M, Stella A, Pasquinelli G
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2014 Oct;48(4):430-7
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2014 Oct;48(4):430-7
2-Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF-1α response after traumatic brain injury in mice.
Schaible EV, Windschügl J, Bobkiewicz W, Kaburov Y, Dangel L, Krämer T, Huang C, Sebastiani A, Luh C, Werner C, Engelhard K, Thal SC, Schäfer MK
Journal of neurochemistry 2014 Jun;129(6):940-54
Journal of neurochemistry 2014 Jun;129(6):940-54
TGF-β/Smad3 inhibit vascular smooth muscle cell apoptosis through an autocrine signaling mechanism involving VEGF-A.
Shi X, Guo LW, Seedial SM, Si Y, Wang B, Takayama T, Suwanabol PA, Ghosh S, DiRenzo D, Liu B, Kent KC
Cell death & disease 2014 Jul 10;5:e1317
Cell death & disease 2014 Jul 10;5:e1317
CTGF is a therapeutic target for metastatic melanoma.
Finger EC, Cheng CF, Williams TR, Rankin EB, Bedogni B, Tachiki L, Spong S, Giaccia AJ, Powell MB
Oncogene 2014 Feb 27;33(9):1093-100
Oncogene 2014 Feb 27;33(9):1093-100
High tumor cell expression of microRNA-21 in node positive non-small cell lung cancer predicts a favorable clinical outcome.
Stenvold H, Donnem T, Andersen S, Al-Saad S, Valkov A, Pedersen MI, Busund LT, Bremnes RM
BMC clinical pathology 2014 Feb 13;14(1):9
BMC clinical pathology 2014 Feb 13;14(1):9
Sporadic hemangioblastomas are characterized by cryptic VHL inactivation.
Shankar GM, Taylor-Weiner A, Lelic N, Jones RT, Kim JC, Francis JM, Abedalthagafi M, Borges LF, Coumans JV, Curry WT, Nahed BV, Shin JH, Paek SH, Park SH, Stewart C, Lawrence MS, Cibulskis K, Thorner AR, Van Hummelen P, Stemmer-Rachamimov AO, Batchelor TT, Carter SL, Hoang MP, Santagata S, Louis DN, Barker FG, Meyerson M, Getz G, Brastianos PK, Cahill DP
Acta neuropathologica communications 2014 Dec 24;2:167
Acta neuropathologica communications 2014 Dec 24;2:167
Treatment with a highly selective β₁ antagonist causes dose-dependent impairment of cerebral perfusion after hemodilution in rats.
Hu T, Beattie WS, Mazer CD, Leong-Poi H, Fujii H, Wilson DF, Tsui AK, Liu E, Muhammad M, Baker AJ, Hare GM
Anesthesia and analgesia 2013 Mar;116(3):649-62
Anesthesia and analgesia 2013 Mar;116(3):649-62
Early histopathologic changes in the retina and optic nerve in canine primary angle-closure glaucoma.
Scott EM, Boursiquot N, Beltran WA, Dubielzig RR
Veterinary ophthalmology 2013 Jul;16 Suppl 1:79-86
Veterinary ophthalmology 2013 Jul;16 Suppl 1:79-86
Tissue hypoxia in pathogenesis of ulcerative colitis: should we change all our beliefs?
Tajdini M, Mirbagheri SA, Nikooie R, Ostovaneh MR, Ghoreyshi Hefzabad SM, Garg SK, Hosseini SM
Scandinavian journal of gastroenterology 2013 Dec;48(12):1487-8
Scandinavian journal of gastroenterology 2013 Dec;48(12):1487-8
BOLD-MRI of breast invasive ductal carcinoma: correlation of R2* value and the expression of HIF-1α.
Liu M, Guo X, Wang S, Jin M, Wang Y, Li J, Liu J
European radiology 2013 Dec;23(12):3221-7
European radiology 2013 Dec;23(12):3221-7
Prognostic assessment of hypoxia and metabolic markers in cervical cancer using automated digital image analysis of immunohistochemistry.
Kim BW, Cho H, Chung JY, Conway C, Ylaya K, Kim JH, Hewitt SM
Journal of translational medicine 2013 Aug 8;11:185
Journal of translational medicine 2013 Aug 8;11:185
p16, Cyclin D1, and HIF-1α Predict Outcomes of Patients with Oropharyngeal Squamous Cell Carcinoma Treated with Definitive Intensity-Modulated Radiation Therapy.
Rahimi AS, Wilson DD, Saylor DK, Stelow EB, Thomas CY, Reibel JF, Levine PA, Shonka DC, Jameson MJ, Read PW
International journal of otolaryngology 2012;2012:685951
International journal of otolaryngology 2012;2012:685951
Prognostic impacts of hypoxic markers in soft tissue sarcoma.
Smeland E, Kilvaer TK, Sorbye S, Valkov A, Andersen S, Bremnes RM, Busund LT, Donnem T
Sarcoma 2012;2012:541650
Sarcoma 2012;2012:541650
An improved method for the study of apoptosis-related genes using the tet-on system.
Halterman MW
Journal of biomolecular screening 2011 Mar;16(3):332-7
Journal of biomolecular screening 2011 Mar;16(3):332-7
Diverging prognostic impacts of hypoxic markers according to NSCLC histology.
Andersen S, Eilertsen M, Donnem T, Al-Shibli K, Al-Saad S, Busund LT, Bremnes RM
Lung cancer (Amsterdam, Netherlands) 2011 Jun;72(3):294-302
Lung cancer (Amsterdam, Netherlands) 2011 Jun;72(3):294-302
Coexpression of hypoxia-inducible factor-1α and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients.
Eckert AW, Lautner MH, Schütze A, Taubert H, Schubert J, Bilkenroth U
Histopathology 2011 Jun;58(7):1136-47
Histopathology 2011 Jun;58(7):1136-47
Loss of epidermal hypoxia-inducible factor-1α accelerates epidermal aging and affects re-epithelialization in human and mouse.
Rezvani HR, Ali N, Serrano-Sanchez M, Dubus P, Varon C, Ged C, Pain C, Cario-André M, Seneschal J, Taïeb A, de Verneuil H, Mazurier F
Journal of cell science 2011 Dec 15;124(Pt 24):4172-83
Journal of cell science 2011 Dec 15;124(Pt 24):4172-83
Hypoxia-induced overexpression of BNIP3 is not dependent on hypoxia-inducible factor 1α in mouse hepatocytes.
Namas RA, Metukuri MR, Dhupar R, Velosa C, Jefferson BS, Myer E, Constantine GM, Billiar TR, Vodovotz Y, Zamora R
Shock (Augusta, Ga.) 2011 Aug;36(2):196-202
Shock (Augusta, Ga.) 2011 Aug;36(2):196-202
Prognostic implications of hypoxia-inducible factor-1α in epidermal growth factor receptor-negative non-small cell lung cancer.
Park S, Ha SY, Cho HY, Chung DH, Kim NR, Hong J, Cho EK
Lung cancer (Amsterdam, Netherlands) 2011 Apr;72(1):100-7
Lung cancer (Amsterdam, Netherlands) 2011 Apr;72(1):100-7
Low-dose radiation augments vasculogenesis signaling through HIF-1-dependent and -independent SDF-1 induction.
Lerman OZ, Greives MR, Singh SP, Thanik VD, Chang CC, Seiser N, Brown DJ, Knobel D, Schneider RJ, Formenti SC, Saadeh PB, Levine JP
Blood 2010 Nov 4;116(18):3669-76
Blood 2010 Nov 4;116(18):3669-76
Hypoxia stimulates CXCR4 signalling in ileal carcinoids.
Arvidsson Y, Bergström A, Arvidsson L, Kristiansson E, Ahlman H, Nilsson O
Endocrine-related cancer 2010 Jun;17(2):303-16
Endocrine-related cancer 2010 Jun;17(2):303-16
Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.
Bennecke M, Kriegl L, Bajbouj M, Retzlaff K, Robine S, Jung A, Arkan MC, Kirchner T, Greten FR
Cancer cell 2010 Aug 9;18(2):135-46
Cancer cell 2010 Aug 9;18(2):135-46
Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration.
Lei Z, Li B, Yang Z, Fang H, Zhang GM, Feng ZH, Huang B
PloS one 2009 Oct 29;4(10):e7629
PloS one 2009 Oct 29;4(10):e7629
Metoprolol reduces cerebral tissue oxygen tension after acute hemodilution in rats.
Ragoonanan TE, Beattie WS, Mazer CD, Tsui AK, Leong-Poi H, Wilson DF, Tait G, Yu J, Liu E, Noronha M, Dattani ND, Mitsakakis N, Hare GM
Anesthesiology 2009 Nov;111(5):988-1000
Anesthesiology 2009 Nov;111(5):988-1000
Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis.
Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot IC, Glynne-Jones R, Northover JM, Guenther T
British journal of cancer 2009 May 19;100(10):1666-73
British journal of cancer 2009 May 19;100(10):1666-73
Hypoxia inducible factor-1alpha correlates with vascular endothelial growth factor A and C indicating worse prognosis in clear cell renal cell carcinoma.
Dorević G, Matusan-Ilijas K, Babarović E, Hadzisejdić I, Grahovac M, Grahovac B, Jonjić N
Journal of experimental & clinical cancer research : CR 2009 Mar 20;28:40
Journal of experimental & clinical cancer research : CR 2009 Mar 20;28:40
Antitumor activity of an oncolytic adenoviral-CD40 ligand (CD154) transgene construct in human breast cancer cells.
Gomes EM, Rodrigues MS, Phadke AP, Butcher LD, Starling C, Chen S, Chang D, Hernandez-Alcoceba R, Newman JT, Stone MJ, Tong AW
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Feb 15;15(4):1317-25
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Feb 15;15(4):1317-25
Hypoxia inducible factor-1 alpha activation of the JCV promoter: role in the pathogenesis of progressive multifocal leukoencephalopathy.
Piña-Oviedo S, Khalili K, Del Valle L
Acta neuropathologica 2009 Aug;118(2):235-47
Acta neuropathologica 2009 Aug;118(2):235-47
Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma.
Reiser-Erkan C, Erkan M, Pan Z, Bekasi S, Giese NA, Streit S, Michalski CW, Friess H, Kleeff J
Cancer biology & therapy 2008 Sep;7(9):1352-9
Cancer biology & therapy 2008 Sep;7(9):1352-9
Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma.
Reiser-Erkan C, Erkan M, Pan Z, Bekasi S, Giese NA, Streit S, Michalski CW, Friess H, Kleeff J
Cancer biology & therapy 2008 Sep;7(9):1352-9
Cancer biology & therapy 2008 Sep;7(9):1352-9
Expression of hypoxia-inducible factor 1alpha gene affects the outcome in patients with ovarian cancer.
Shimogai R, Kigawa J, Itamochi H, Iba T, Kanamori Y, Oishi T, Shimada M, Sato S, Kawaguchi W, Sato S, Terakawa N
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2008 May-Jun;18(3):499-505
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2008 May-Jun;18(3):499-505
Expression of hypoxia-inducible factor-1alpha and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours.
Kubo T, Sugita T, Shimose S, Matsuo T, Arihiro K, Ochi M
The Journal of bone and joint surgery. British volume 2008 Mar;90(3):364-70
The Journal of bone and joint surgery. British volume 2008 Mar;90(3):364-70
Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores.
Hartmann H, Eltzschig HK, Wurz H, Hantke K, Rakin A, Yazdi AS, Matteoli G, Bohn E, Autenrieth IB, Karhausen J, Neumann D, Colgan SP, Kempf VA
Gastroenterology 2008 Mar;134(3):756-67
Gastroenterology 2008 Mar;134(3):756-67
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia.
Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, Strauss JF, Kalluri R
Nature 2008 Jun 19;453(7198):1117-21
Nature 2008 Jun 19;453(7198):1117-21
p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury.
Sutton TA, Wilkinson J, Mang HE, Knipe NL, Plotkin Z, Hosein M, Zak K, Wittenborn J, Dagher PC
American journal of physiology. Renal physiology 2008 Dec;295(6):F1666-77
American journal of physiology. Renal physiology 2008 Dec;295(6):F1666-77
In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy.
Viola RJ, Provenzale JM, Li F, Li CY, Yuan H, Tashjian J, Dewhirst MW
AJR. American journal of roentgenology 2008 Dec;191(6):1779-84
AJR. American journal of roentgenology 2008 Dec;191(6):1779-84
Differential regulation of hypoxia-induced CXCR4 triggering during B-cell development and lymphomagenesis.
Piovan E, Tosello V, Indraccolo S, Masiero M, Persano L, Esposito G, Zamarchi R, Ponzoni M, Chieco-Bianchi L, Dalla-Favera R, Amadori A
Cancer research 2007 Sep 15;67(18):8605-14
Cancer research 2007 Sep 15;67(18):8605-14
Over-expression of hypoxia-inducible factor 1 alpha in ovarian clear cell carcinoma.
Lee S, Garner EI, Welch WR, Berkowitz RS, Mok SC
Gynecologic oncology 2007 Aug;106(2):311-7
Gynecologic oncology 2007 Aug;106(2):311-7
Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands.
Monsef N, Helczynski L, Lundwall A, Påhlman S, Anders-Bjartell.
The Prostate 2007 Aug 1;67(11):1219-29
The Prostate 2007 Aug 1;67(11):1219-29
In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfate.
Kyriacou HM, Steen KE, Raza A, Arman M, Warimwe G, Bull PC, Havlik I, Rowe JA
Antimicrobial agents and chemotherapy 2007 Apr;51(4):1321-6
Antimicrobial agents and chemotherapy 2007 Apr;51(4):1321-6
CoCl2-induced HIF-1alpha expression correlates with proliferation and apoptosis in MKN-1 cells: a possible role for the PI3K/Akt pathway.
Ardyanto TD, Osaki M, Tokuyasu N, Nagahama Y, Ito H
International journal of oncology 2006 Sep;29(3):549-55
International journal of oncology 2006 Sep;29(3):549-55
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation.
Khan Z, Michalopoulos GK, Stolz DB
The American journal of pathology 2006 Oct;169(4):1251-69
The American journal of pathology 2006 Oct;169(4):1251-69
Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors.
Carroll PA, Kenerson HL, Yeung RS, Lagunoff M
Journal of virology 2006 Nov;80(21):10802-12
Journal of virology 2006 Nov;80(21):10802-12
Hypoxia at the site of abdominal aortic aneurysm rupture is not associated with increased lactate.
Choke E, Cockerill GW, Dawson J, Chung YL, Griffiths J, Wilson RW, Loftus IM, Thompson MM
Annals of the New York Academy of Sciences 2006 Nov;1085:306-10
Annals of the New York Academy of Sciences 2006 Nov;1085:306-10
Hypoxia-inducible factor 1alpha expression in renal cell carcinoma analyzed by tissue microarray.
Lidgren A, Hedberg Y, Grankvist K, Rasmuson T, Bergh A, Ljungberg B
European urology 2006 Dec;50(6):1272-7
European urology 2006 Dec;50(6):1272-7
Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1alpha in non-small cell lung cancers.
Hirami Y, Aoe M, Tsukuda K, Hara F, Otani Y, Koshimune R, Hanabata T, Nagahiro I, Sano Y, Date H, Shimizu N
Cancer letters 2004 Oct 28;214(2):157-64
Cancer letters 2004 Oct 28;214(2):157-64
Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe?
Abbate A, Santini D, Biondi-Zoccai GG, Scarpa S, Vasaturo F, Liuzzo G, Bussani R, Silvestri F, Baldi F, Crea F, Biasucci LM, Baldi A
Heart (British Cardiac Society) 2004 Apr;90(4):440-3
Heart (British Cardiac Society) 2004 Apr;90(4):440-3
Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe?
Abbate A, Santini D, Biondi-Zoccai GG, Scarpa S, Vasaturo F, Liuzzo G, Bussani R, Silvestri F, Baldi F, Crea F, Biasucci LM, Baldi A
Heart (British Cardiac Society) 2004 Apr;90(4):440-3
Heart (British Cardiac Society) 2004 Apr;90(4):440-3
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.
Beasley NJ, Leek R, Alam M, Turley H, Cox GJ, Gatter K, Millard P, Fuggle S, Harris AL
Cancer research 2002 May 1;62(9):2493-7
Cancer research 2002 May 1;62(9):2493-7
Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer.
Giatromanolaki A, Koukourakis MI, Sivridis E, Pastorek J, Wykoff CC, Gatter KC, Harris AL
Cancer research 2001 Nov 1;61(21):7992-8
Cancer research 2001 Nov 1;61(21):7992-8
Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy.
Koukourakis MI, Giatromanolaki A, Skarlatos J, Corti L, Blandamura S, Piazza M, Gatter KC, Harris AL
Cancer research 2001 Mar 1;61(5):1830-2
Cancer research 2001 Mar 1;61(5):1830-2
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL
The American journal of pathology 2000 Aug;157(2):411-21
The American journal of pathology 2000 Aug;157(2):411-21
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL
The American journal of pathology 2000 Aug;157(2):411-21
The American journal of pathology 2000 Aug;157(2):411-21
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
Wiesener MS, Turley H, Allen WE, Willam C, Eckardt KU, Talks KL, Wood SM, Gatter KC, Harris AL, Pugh CW, Ratcliffe PJ, Maxwell PH
Blood 1998 Oct 1;92(7):2260-8
Blood 1998 Oct 1;92(7):2260-8
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Supportive validation
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- Simple Western: HIF-1 alpha Antibody (ESEE122) [NB100-131] - Image shows a specific band for HIF-1 alpha in 0.5 mg/mL of Hypoxic HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
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- Western Blot: HIF-1 alpha Antibody (ESEE122) [NB100-131] - HIF-1 alpha in Cos7 cells treated or untreated with CoCl2.
Supportive validation
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- Immunohistochemistry-Paraffin: HIF-1 alpha Antibody (ESEE122) [NB100-131] - Analysis of a FFPE mouse kidney tissue section using HIF-1 alpha antibody clone ESEE122 at 1ug/mL concentration. The detection was performed using X-cell plus universal HRP polymer detection system with Vector SG chromagen substrate. Image courtesy of a product review by Steven Grover.
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- Immunohistochemistry-Paraffin: HIF-1 alpha Antibody (ESEE122) [NB100-131] - Analysis of HIF-1 alpha in paraffin-embedded mouse kidney tissue section using anti-HIF-1 alpha antibody. Image from verified customer review.
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- Immunohistochemistry-Paraffin: HIF-1 alpha Antibody (ESEE122) [NB100-131] - Negative control stain of human placenta (from sea level) using mouse IgG at 1:100. 4uM paraffin-embedded section.
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- Immunohistochemistry-Paraffin: HIF-1 alpha Antibody (ESEE122) [NB100-131] - Analysis of a FFPE tissue section of human renal cancer xenograft using HIF-1 alpha antibody (NB100-131 Lot 83115) at 1:200 dilution. The antibody generated a strong cytoplasmic staining mainly in the cancer cells. Only a fraction of cells depicted nuclear staining, while weak to negligible positivity was seen in the tumor stromal cells.
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- Immunohistochemistry: HIF-1 alpha Antibody (ESEE122) [NB100-131] - HIF-1 alpha staining in hypoxia-induced human placenta.
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- Immunohistochemistry: HIF-1 alpha Antibody (ESEE122) [NB100-131] - Histologically distinct cell types in hemangioblastomas do not arise from a common ancestral clone. Representative images of sample SH-0622 acquired at 400x of (a) H + E and IHC for (b) HIF1-alpha reveal heterogenous cell types in this tumor characterized by a rich vascular network. Arrowheads indicate that the stromal cells demonstrate increased cytoplasmic staining for HIF1-alpha and VEGF, whereas the double arrowheads highlight PDGFR-beta protein restricted to vascular endothelium. Scale bar is 25 um. Image collected and cropped by CiteAb from the following publication (http://www.actaneurocomms.org/content/2/1/167), licensed under a CC-BY licence.
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- Immunohistochemistry: HIF-1 alpha Antibody (ESEE122) [NB100-131] - Immunohistochemical analysis in non-GIST STS representing negative, and score 1-3 of Carbonic Anhydrase IX/CA9, GLUT-1, HIF-1 alpha, and HIF-2 alpha/EPAS1. non-GIST STS: non-gastrointestinal stromal tumor soft-tissue sarcomas, Carbonic Anhydrase IX/CA9: carbonic anhydrase IX, GLUT-1: glucose transporter-1, and HIF-1/2alpha: hypoxia induced factor 1/2alpha. Image collected and cropped by CiteAb from the following publication (http://www.hindawi.com/journals/sarcoma/2012/541650/), licensed under a CC-BY licence.
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- Immunohistochemistry: HIF-1 alpha Antibody (ESEE122) [NB100-131] - Immunohistochemical staining of HIF-1 alpha in normal renal tissue (A) and clear cell renal cell carcinoma (CCRCC) (D). A homogeneous cytoplasmic staining of tubular cells and weak staining in glomerules was observed with HIF-1 alpha (A). In CCRCC, HIF-1 alpha immmunoreactivity was nuclear and/or cytoplasmic (D), while it was perimembranous and/or diffuse cytoplasmic for VEGF-A and VEFG-C (E and F). (magnification x200). Image collected and cropped by CiteAb from the following publication (http://www.jeccr.com/content/28/1/40), licensed under a CC-BY licence.
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- Immunohistochemistry-Paraffin: HIF-1 alpha Antibody (ESEE122) [NB100-131] - Representative immunohistochemical expression for HIF-1alpha, c-Met, CA9 and GLUT1. HIF-1alpha is stained in cytoplasm shown with no staining in normal cervix (A), weak staining intensity in high grade CIN (B), and strong staining intensity in squamous cell carcinoma (C). Scale bar: 50 um. Image collected and cropped by CiteAb from the following publication (http://www.translational-medicine.com/content/11/1/185), licensed under a CC-BY licence.
