Antibody data
- Antibody Data
- Antigen structure
- References [41]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 20687-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20687-1-AP, RRID:AB_10700012
- Product name
- Notch1 antibody
- Antibody type
- Polyclonal
- Description
- NOTCH1 antibody (Cat. #20687-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Hibiscus syriacus L. cultivated in callus culture exerts cytotoxicity in colorectal cancer via Notch signaling-mediated cholesterol biosynthesis suppression.
Linc-KILH potentiates Notch1 signaling through inhibiting KRT19 phosphorylation and promotes the malignancy of hepatocellular carcinoma.
UBE3A activates the NOTCH pathway and promotes esophageal cancer progression by degradation of ZNF185.
Combination of an engineered Lactococcus lactis expressing CXCL12 with light-emitting diode yellow light as a treatment for scalded skin in mice.
Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells.
Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration.
Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.
hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.
ANXA1 affects murine hair follicle growth through EGF signaling pathway.
GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells.
Reduced expression of ppGalNAc-T4 promotes proliferation of human breast cancer cells.
Knockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells.
Human umbilical vein endothelial cells derived-exosomes promote osteosarcoma cell stemness by activating Notch signaling pathway.
ILC2s induce adaptive Th2-type immunity in different stages of tuberculosis through the Notch-GATA3 pathway.
Transcriptional control of brain tumor stem cells by a carbohydrate binding protein.
Microarray Analysis of Long Non-Coding RNAs in Lung Tissues of Patients with COPD and HOXA-AS2 Promotes HPMECs Proliferation via Notch1.
miR-4270 regulates cell proliferation and apoptosis in patients with Sertoli cell-only syndrome by targeting GADD45A and inactivating the NOTCH signaling pathway.
ST3Gal IV Mediates the Growth and Proliferation of Cervical Cancer Cells In Vitro and In Vivo Via the Notch/p21/CDKs Pathway.
Notch1 contributes to TNF-α-induced proliferation and migration of airway smooth muscle cells through regulation of the Hes1/PTEN axis.
A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.
Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway.
Norepinephrine transporter promotes the invasion of human colon cancer cells.
Downregulation of lung miR-203a-3p expression by high-altitude hypoxia enhances VEGF/Notch signaling.
1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.
Stromal fibroblast-derived MFAP5 promotes the invasion and migration of breast cancer cells via Notch1/slug signaling.
miR-214-5p suppresses the proliferation, migration and invasion of trophoblast cells in pre-eclampsia by targeting jagged 1 to inhibit notch signaling pathway.
Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium.
MYCN-mediated regulation of the HES1 promoter enhances the chemoresistance of small-cell lung cancer by modulating apoptosis.
Inhibition of microRNA-34a Suppresses Epileptiform Discharges Through Regulating Notch Signaling and Apoptosis in Cultured Hippocampal Neurons.
Vasorin stimulates malignant progression and angiogenesis in glioma.
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Notch inhibitor can attenuate apparent diffusion coefficient and improve neurological function through downregulating NOX2-ROS in severe traumatic brain injury.
Modification of α2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.
miR-34a is involved in CSE-induced apoptosis of human pulmonary microvascular endothelial cells by targeting Notch-1 receptor protein.
Long non-coding RNA LINC00152 promotes cell proliferation, metastasis, and confers 5-FU resistance in colorectal cancer by inhibiting miR-139-5p.
Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway.
Luteolin suppresses gastric cancer progression by reversing epithelial-mesenchymal transition via suppression of the Notch signaling pathway.
Downregulated protein O-fucosyl transferase 1 (Pofut1) expression exerts antiproliferative and antiadhesive effects on hepatocytes by inhibiting Notch signalling.
Notch1 is a potential therapeutic target for the treatment of human hepatitis B virus X protein-associated hepatocellular carcinoma.
The olfactory bulb in newborn piglet is a reservoir of neural stem and progenitor cells.
Xu XY, Choi HS, Park SY, Kim JK, Seo KH, Kim H, Kim YJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153870
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153870
Linc-KILH potentiates Notch1 signaling through inhibiting KRT19 phosphorylation and promotes the malignancy of hepatocellular carcinoma.
Zhang X, Xu X, Zhang Z, Xue C, Kong Z, Wu S, Yun X, Fu Y, Zhu C, Qin X
International journal of biological sciences 2021;17(3):768-780
International journal of biological sciences 2021;17(3):768-780
UBE3A activates the NOTCH pathway and promotes esophageal cancer progression by degradation of ZNF185.
Zheng Z, Zhang B, Yu H, Li S, Song N, Jin X, Li J
International journal of biological sciences 2021;17(12):3024-3035
International journal of biological sciences 2021;17(12):3024-3035
Combination of an engineered Lactococcus lactis expressing CXCL12 with light-emitting diode yellow light as a treatment for scalded skin in mice.
Zhao X, Li S, Ding J, Wei J, Tian P, Wei H, Chen T
Microbial biotechnology 2021 Sep;14(5):2090-2100
Microbial biotechnology 2021 Sep;14(5):2090-2100
Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells.
Cheng L, Xie M, Qiao W, Song Y, Zhang Y, Geng Y, Xu W, Wang L, Wang Z, Huang K, Dong N, Sun Y
Communications biology 2021 Sep 6;4(1):1039
Communications biology 2021 Sep 6;4(1):1039
Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration.
Ding R, Li G, Yao Y, Zhang L, Zhang X, Li J, Shen T, Gao Y, Wu T, Kong S, Huang M, Li Y
Journal of physiology and biochemistry 2021 Sep 23;
Journal of physiology and biochemistry 2021 Sep 23;
Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.
Kaneko T, Horiuchi K, Chijimatsu R, Mori D, Nagata K, Omata Y, Yano F, Inui H, Moro T, Tanaka S, Saito T
Journal of bone and mineral metabolism 2021 Nov 9;
Journal of bone and mineral metabolism 2021 Nov 9;
hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.
Wan X, Zhu L, Zhao L, Peng L, Xiong J, Yang W, Yuan J, Liang F, Zhang K, Chen K
Cell death & disease 2021 Mar 19;12(4):301
Cell death & disease 2021 Mar 19;12(4):301
ANXA1 affects murine hair follicle growth through EGF signaling pathway.
Zhang H, Fu X, Ao Y, Nan M, Qiu Z, Jia X, Xiao Y, Liu D, Guo X
Gene 2021 Mar 1;771:145343
Gene 2021 Mar 1;771:145343
GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
Wang W, Sun R, Zeng L, Chen Y, Zhang N, Cao S, Deng S, Meng X, Yang S
Life sciences 2021 Jul 1;276:119439
Life sciences 2021 Jul 1;276:119439
ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells.
Ma L, Li C, Lian S, Xu B, Yuan J, Lu J, Yang H, Guo J, Ji H
Molecular and cellular endocrinology 2021 Jan 1;519:111055
Molecular and cellular endocrinology 2021 Jan 1;519:111055
Reduced expression of ppGalNAc-T4 promotes proliferation of human breast cancer cells.
Wu Q, Xie X, Zhang K, Niang B, Liu Y, Zhang C, Huang T, Huang H, Li W, Zhang J, Liu Y
Cell biology international 2021 Feb;45(2):320-333
Cell biology international 2021 Feb;45(2):320-333
Knockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells.
Xu Q, Liu Z, Zhu ZQ, Fan Y, Chen R, Xie XH, Cheng M
Bioengineered 2021 Dec;12(2):12179-12190
Bioengineered 2021 Dec;12(2):12179-12190
Human umbilical vein endothelial cells derived-exosomes promote osteosarcoma cell stemness by activating Notch signaling pathway.
Yang J, Hu Y, Wang L, Sun X, Yu L, Guo W
Bioengineered 2021 Dec;12(2):11007-11017
Bioengineered 2021 Dec;12(2):11007-11017
ILC2s induce adaptive Th2-type immunity in different stages of tuberculosis through the Notch-GATA3 pathway.
Li Q, Zhang J, Ma L, Wu C, Zhao J, Guan W, Li X, Yang X, Wen F
International immunopharmacology 2021 Dec;101(Pt B):108330
International immunopharmacology 2021 Dec;101(Pt B):108330
Transcriptional control of brain tumor stem cells by a carbohydrate binding protein.
Sharanek A, Burban A, Hernandez-Corchado A, Madrigal A, Fatakdawala I, Najafabadi HS, Soleimani VD, Jahani-Asl A
Cell reports 2021 Aug 31;36(9):109647
Cell reports 2021 Aug 31;36(9):109647
Microarray Analysis of Long Non-Coding RNAs in Lung Tissues of Patients with COPD and HOXA-AS2 Promotes HPMECs Proliferation via Notch1.
Zhou AY, Zhao YY, Zhou ZJ, Duan JX, Zhu YZ, Cai S, Chen P
International journal of chronic obstructive pulmonary disease 2020;15:2449-2460
International journal of chronic obstructive pulmonary disease 2020;15:2449-2460
miR-4270 regulates cell proliferation and apoptosis in patients with Sertoli cell-only syndrome by targeting GADD45A and inactivating the NOTCH signaling pathway.
Wang H, Huang Z, Zhao X, Guo B, Ji Z
American journal of translational research 2020;12(9):5730-5740
American journal of translational research 2020;12(9):5730-5740
ST3Gal IV Mediates the Growth and Proliferation of Cervical Cancer Cells In Vitro and In Vivo Via the Notch/p21/CDKs Pathway.
Wu Y, Chen X, Dong W, Xu Z, Jian Y, Xu C, Zhang L, Wei A, Yu X, Wang S, Wang Y, Liu G, Sun X, Wang S
Frontiers in oncology 2020;10:540332
Frontiers in oncology 2020;10:540332
Notch1 contributes to TNF-α-induced proliferation and migration of airway smooth muscle cells through regulation of the Hes1/PTEN axis.
Li X, Zou F, Lu Y, Fan X, Wu Y, Feng X, Sun X, Liu Y
International immunopharmacology 2020 Nov;88:106911
International immunopharmacology 2020 Nov;88:106911
A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.
Lu C, Ren C, Yang T, Sun Y, Qiao P, Wang D, Lv S, Yu Z
Molecular cancer research : MCR 2020 May;18(5):787-796
Molecular cancer research : MCR 2020 May;18(5):787-796
Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway.
Wang Z, Nan W, Si H, Wang S, Zhang H, Li G
Life sciences 2020 Jul 1;252:117667
Life sciences 2020 Jul 1;252:117667
Norepinephrine transporter promotes the invasion of human colon cancer cells.
Zhang H, Miao J, Li F, Xue W, Tang K, Zhao X, Jing X, Zhang J, Huang C, Hou N, Han J
Oncology letters 2020 Jan;19(1):824-832
Oncology letters 2020 Jan;19(1):824-832
Downregulation of lung miR-203a-3p expression by high-altitude hypoxia enhances VEGF/Notch signaling.
Cai W, Liu S, Liu Z, Hou S, Lv Q, Cui H, Wang X, Zhang Y, Fan H, Ding H
Aging 2020 Feb 29;12(5):4247-4267
Aging 2020 Feb 29;12(5):4247-4267
1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.
Jia Z, Zhang Y, Yan A, Wang M, Han Q, Wang K, Wang J, Qiao C, Pan Z, Chen C, Hu D, Ding X
Cell death & disease 2020 Aug 20;11(8):670
Cell death & disease 2020 Aug 20;11(8):670
Stromal fibroblast-derived MFAP5 promotes the invasion and migration of breast cancer cells via Notch1/slug signaling.
Chen Z, Yan X, Li K, Ling Y, Kang H
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2020 Apr;22(4):522-531
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2020 Apr;22(4):522-531
miR-214-5p suppresses the proliferation, migration and invasion of trophoblast cells in pre-eclampsia by targeting jagged 1 to inhibit notch signaling pathway.
Gong F, Chai W, Wang J, Cheng H, Shi Y, Cui L, Jia G
Acta histochemica 2020 Apr;122(3):151527
Acta histochemica 2020 Apr;122(3):151527
Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium.
Guo Y, Cheng BYL, Wang D, Ma ACH, He BL, Man TK, Cheung MPL, Shi X, Ng NKL, Leung AYH
Stem cell reports 2020 Apr 14;14(4):575-589
Stem cell reports 2020 Apr 14;14(4):575-589
MYCN-mediated regulation of the HES1 promoter enhances the chemoresistance of small-cell lung cancer by modulating apoptosis.
Tong Q, Ouyang S, Chen R, Huang J, Guo L
American journal of cancer research 2019;9(9):1938-1956
American journal of cancer research 2019;9(9):1938-1956
Inhibition of microRNA-34a Suppresses Epileptiform Discharges Through Regulating Notch Signaling and Apoptosis in Cultured Hippocampal Neurons.
Wang J, Zheng Y, Cheng X, Xu F, Zhang P, Zhou X, Zhao H
Neurochemical research 2019 May;44(5):1252-1261
Neurochemical research 2019 May;44(5):1252-1261
Vasorin stimulates malignant progression and angiogenesis in glioma.
Liang W, Guo B, Ye J, Liu H, Deng W, Lin C, Zhong X, Wang L
Cancer science 2019 Aug;110(8):2558-2572
Cancer science 2019 Aug;110(8):2558-2572
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Notch inhibitor can attenuate apparent diffusion coefficient and improve neurological function through downregulating NOX2-ROS in severe traumatic brain injury.
Zhang HM, Chen W, Liu RN, Zhao Y
Drug design, development and therapy 2018;12:3847-3854
Drug design, development and therapy 2018;12:3847-3854
Modification of α2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.
Yuan Q, Chen X, Han Y, Lei T, Wu Q, Yu X, Wang L, Fan Z, Wang S
International journal of cancer 2018 Nov 1;143(9):2319-2330
International journal of cancer 2018 Nov 1;143(9):2319-2330
miR-34a is involved in CSE-induced apoptosis of human pulmonary microvascular endothelial cells by targeting Notch-1 receptor protein.
Long YJ, Liu XP, Chen SS, Zong DD, Chen Y, Chen P
Respiratory research 2018 Jan 26;19(1):21
Respiratory research 2018 Jan 26;19(1):21
Long non-coding RNA LINC00152 promotes cell proliferation, metastasis, and confers 5-FU resistance in colorectal cancer by inhibiting miR-139-5p.
Bian Z, Zhang J, Li M, Feng Y, Yao S, Song M, Qi X, Fei B, Yin Y, Hua D, Huang Z
Oncogenesis 2017 Nov 28;6(11):395
Oncogenesis 2017 Nov 28;6(11):395
Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway.
Yao M, Gao F, Wang X, Shi Y, Liu S, Duan H
Molecular medicine reports 2017 Jun;15(6):4319-4325
Molecular medicine reports 2017 Jun;15(6):4319-4325
Luteolin suppresses gastric cancer progression by reversing epithelial-mesenchymal transition via suppression of the Notch signaling pathway.
Zang MD, Hu L, Fan ZY, Wang HX, Zhu ZL, Cao S, Wu XY, Li JF, Su LP, Li C, Zhu ZG, Yan M, Liu BY
Journal of translational medicine 2017 Feb 27;15(1):52
Journal of translational medicine 2017 Feb 27;15(1):52
Downregulated protein O-fucosyl transferase 1 (Pofut1) expression exerts antiproliferative and antiadhesive effects on hepatocytes by inhibiting Notch signalling.
Annani-Akollor ME, Wang S, Fan J, Liu L, Padhiar AA, Zhang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2014 Jul;68(6):785-90
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2014 Jul;68(6):785-90
Notch1 is a potential therapeutic target for the treatment of human hepatitis B virus X protein-associated hepatocellular carcinoma.
Sun Q, Wang R, Wang Y, Luo J, Wang P, Cheng B
Oncology reports 2014 Feb;31(2):933-9
Oncology reports 2014 Feb;31(2):933-9
The olfactory bulb in newborn piglet is a reservoir of neural stem and progenitor cells.
Martin LJ, Katzenelson A, Koehler RC, Chang Q
PloS one 2013;8(11):e81105
PloS one 2013;8(11):e81105
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 20687-1-AP(NOTCH1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung using 20687-1-AP(NOTCH1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NOTCH1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human NOTCH1. This antibody recognizes human, mouse, rat, zebrafish antigen. The NOTCH1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.