10062-2-AP

antibody from Proteintech Group

Targeting: NOTCH1 TAN1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

10062-2-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10062-2-AP, RRID:AB_2153338

Product name

Notch1 antibody

Antibody type

Polyclonal

Description

KD/KO validated Notch1 antibody (Cat. #10062-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

ZNF217-activated Notch signaling mediates sulforaphane-suppressed stem cell properties in colorectal cancer.

Wang M, Tang L, Chen S, Wang L, Wu J, Zhong C, Li Y, Chen Y
The Journal of nutritional biochemistry 2024 Mar;125:109551

---

Modulating Th1/Th2 drift in asthma-related immune inflammation by enhancing bone mesenchymal stem cell homing through targeted inhibition of the Notch1/Jagged1 signaling pathway.

Kun W, Xiaomei C, Lei Y, Huizhi Z
International immunopharmacology 2024 Mar 30;130:111713

---

Distinct cellular microenvironment with cytotypic effects regulates orderly regeneration of vascular tissues.

Wang J, Yang X, Xu M, Liu H, Liu L, Tan Z
Materials today. Bio 2024 Jun;26:101033

---

Linarin Ameliorates Restenosis After Vascular Injury in Type 2 Diabetes Mellitus via Regulating ADAM10-Mediated Notch Signaling Pathway.

Jiang A, Liu L, Wang J, Liu Y, Deng S, Jiang T
Cardiovascular toxicology 2024 Jun;24(6):587-597

---

ZEB2 alleviates Hirschsprung's-associated enterocolitis by promoting the proliferation and differentiation of enteric neural precursor cells via the Notch-1/Jagged-2 pathway.

Feng Y, Zhou C, Zhao F, Ma T, Xiao Y, Peng K, Xia R
Gene 2024 Jun 20;912:148365

---

Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice.

Li N, Zhu C, Fu R, Ma X, Duan Z, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155287

---

NOTCH1 as a Negative Regulator of Avian Adipocyte Differentiation: Implications for Fat Deposition.

Wang Z, Su Y, Zhao M, Ma Z, Li J, Hou Z, Li H
Animals : an open access journal from MDPI 2024 Feb 9;14(4)

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Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NFκB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia.

Li W, Miao H, Nie Z, Wu F, Li H
Journal of integrative neuroscience 2024 Feb 18;23(2):34

---

HSF1 Increases EOGT-Mediated Glycosylation of Notch1 to Promote IL-1β-Induced Inflammatory Injury of Chondrocytes.

Huang Y, Pan W, Bao H, Sun X, Xu C, Ma J
Cartilage 2024 Feb 16;:19476035241229211

---

The bone-protective benefits of kaempferol combined with metformin by regulation of osteogenesis-angiogenesis coupling in OVX rats.

Zhang Z, Xu W, Zhang Z, Chen X, Jin H, Jiang N, Xu H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Apr;173:116364

---

B Lymphocytes Balance Th1/Th2 to Participate in Fibrotic Hypersensitivity Pneumonia Induced by Pigeon Shedding.

Wu C, Ding W, Li Y, Wang W, Lian Z, Muhataer X, Zhou Y, Li Q, Yang X
International archives of allergy and immunology 2023;184(2):122-131

---

Adiponectin inhibits TGF-β1-induced skin fibroblast proliferation and phenotype transformation via the p38 MAPK signaling pathway.

Wang X, Yan X, Huang F, Wu L
Open life sciences 2023;18(1):20220679

---

Jiawei Danxuan Koukang Alleviates Arecoline Induced Oral Mucosal Lesions: Network Pharmacology and the Combined Ultra-High Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS).

Zhou L, Tan J, Dai Y, Zhu K, Xiao Y, Wu D, Wang Z, Tan Y, Qin Y
Drug design, development and therapy 2023;17:3085-3101

---

MOGS promotes stemness acquisition and invasion via enhancing NOTCH1-glycosylation dependent NOTCH pathway in colorectal cancer.

Zhou S, Huang H, Zheng Z, Zheng K, Xie L
American journal of cancer research 2023;13(12):5996-6010

---

The Circadian System Is Essential for the Crosstalk of VEGF-Notch-mediated Endothelial Angiogenesis in Ischemic Stroke.

Zhang Y, Zhao X, Guo C, Zhang Y, Zeng F, Yin Q, Li Z, Shao L, Zhou D, Liu L
Neuroscience bulletin 2023 Sep;39(9):1375-1395

---

PCSK9 Inhibition Regulates Infarction-Induced Cardiac Myofibroblast Transdifferentiation via Notch1 Signaling.

Wu C, Lin D, Ji J, Jiang Y, Jiang F, Wang Y
Cell biochemistry and biophysics 2023 Jun;81(2):359-369

---

Expression of type VI collagen α3 chain in canine mammary carcinomas.

Araki M, Noguchi S, Kubo Y, Yasuda A, Koh M, Otsuka H, Yokosuka M, Soeta S
Research in veterinary science 2023 Jun;159:171-182

---

Thallium exposure induces changes in B and T cell generation in mice.

Li D, Li L, Yao H, Su Q, Ye J
Toxicology 2023 Jun 15;492:153532

---

Ginsenoside Rg1 promotes astrocyte-to-neuron transdifferentiation in rat and its possible mechanism.

Shen K, Wu D, Sun B, Zhu Y, Wang H, Zou W, Ma Y, Lu Z
CNS neuroscience & therapeutics 2023 Jan;29(1):256-269

---

Notch1 signalling controls the differentiation and function of myeloid-derived suppressor cells in systemic lupus erythematosus.

Li X, Fei F, Yao G, Yang X, Geng L, Wang D, Gao Y, Hou Y, Sun L
Immunology 2023 Jan;168(1):170-183

---

Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.

Liao Z, Ke W, Liu H, Tong B, Wang K, Feng X, Hua W, Wang B, Song Y, Luo R, Liang H, Zhang W, Zhao K, Li S, Yang C
Journal of nanobiotechnology 2022 Sep 19;20(1):420

---

Siah1 promotes the proliferation of NSCLC cells through ubiquitinating and stabilizing Notch1.

Liu Y, Li Q, Geng L, Zhou X, Zhou X, Dong Y, Zhang Y
Experimental cell research 2022 Oct 1;419(1):113305

---

RHBDL2 promotes the proliferation, migration, and invasion of pancreatic cancer by stabilizing the N1ICD via the OTUD7B and activating the Notch signaling pathway.

Chen S, Cai K, Zheng D, Liu Y, Li L, He Z, Sun C, Yu C
Cell death & disease 2022 Nov 9;13(11):945

---

The effect of mitochondrial fusion on chondrogenic differentiation of cartilage progenitor/stem cells via Notch2 signal pathway.

Moqbel SAA, Zeng R, Ma D, Xu L, Lin C, He Y, Ma C, Xu K, Ran J, Jiang L, Wu L
Stem cell research & therapy 2022 Mar 25;13(1):127

---

A homogalacturonan from Lonicera japonica Thunb. disrupts angiogenesis via epidermal growth factor receptor and Delta-like 4 associated signaling.

Liao W, Hu X, Du Z, Wang P, Ding K
Glycoconjugate journal 2022 Dec;39(6):725-735

---

miR-141-3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1.

Xin X, Duan L, Yang H, Yu H, Bao Y, Jia D, Wu N, Qiao Y
Environmental toxicology 2022 Apr;37(4):741-753

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Screening and identification of NOTCH1, CDKN2A, and NOS3 as differentially expressed autophagy-related genes in erectile dysfunction.

Luo C, Zhou X, Wang L, Zeng Q, Fan J, He S, Zhang H, Wei A
PeerJ 2021;9:e11986

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Lipoxin A4 regulates microglial M1/M2 polarization after cerebral ischemia-reperfusion injury via the Notch signaling pathway.

Li QQ, Ding DH, Wang XY, Sun YY, Wu J
Experimental neurology 2021 May;339:113645

---

Liraglutide regulates proliferation, differentiation, and apoptosis of preosteoblasts through a signaling network of Notch/Wnt/Hedgehog signaling pathways.

Hou HW, Xue P, Wang Y, Li YK
European review for medical and pharmacological sciences 2020 Dec;24(23):12408-12422

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Epithelial-mesenchymal transition induced cancer-stem-cell-like characteristics in hepatocellular carcinoma.

Jing L, Ruan Z, Sun H, Li Q, Han L, Huang L, Yu S, Wang Y, Guo H, Jiao M
Journal of cellular physiology 2019 Aug;234(10):18448-18458

---

Engagement of circular RNA HECW2 in the nonautophagic role of ATG5 implicated in the endothelial-mesenchymal transition.

Yang L, Han B, Zhang Y, Bai Y, Chao J, Hu G, Yao H
Autophagy 2018;14(3):404-418

---

Notch signaling inhibitor DAPT provides protection against acute craniocerebral injury.

Zhang HM, Liu P, Jiang C, Jin XQ, Liu RN, Li SQ, Zhao Y
PloS one 2018;13(2):e0193037

---

POFUT1 promotes colorectal cancer development through the activation of Notch1 signaling.

Du Y, Li D, Li N, Su C, Yang C, Lin C, Chen M, Wu R, Li X, Hu G
Cell death & disease 2018 Sep 24;9(10):995

---

A gene mutation in RNA-binding protein 10 is associated with lung adenocarcinoma progression and poor prognosis.

Yin LL, Wen XM, Li M, Xu YM, Zhao XF, Li J, Wang XW
Oncology letters 2018 Nov;16(5):6283-6292

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Potential role of the Jagged1/Notch1 signaling pathway in the endothelial-myofibroblast transition during BLM-induced pulmonary fibrosis.

Yin Q, Wang W, Cui G, Yan L, Zhang S
Journal of cellular physiology 2018 Mar;233(3):2451-2463

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The Involvement of Notch1-RBP-Jk/Msx2 Signaling Pathway in Aortic Calcification of Diabetic Nephropathy Rats.

Gong C, Li L, Qin C, Wu W, Liu Q, Li Y, Gan L, Ou S
Journal of diabetes research 2017;2017:8968523

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Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.

Liu M, Liang K, Zhen J, Zhou M, Wang X, Wang Z, Wei X, Zhang Y, Sun Y, Zhou Z, Su H, Zhang C, Li N, Gao C, Peng J, Yi F
Nature communications 2017 Sep 4;8(1):413

---

Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation.

Yao S, Xu F, Chen Y, Ge Y, Zhang F, Huang H, Li L, Lin D, Luo X, Xu J, Luo D, Zhu X, Liu Y
Journal of experimental & clinical cancer research : CR 2017 Jan 10;36(1):10

---

Thymosin beta 4 silencing suppresses proliferation and invasion of non-small cell lung cancer cells by repressing Notch1 activation.

Huang D, Wang S, Wang A, Chen X, Zhang H
Acta biochimica et biophysica Sinica 2016 Sep;48(9):788-94

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Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth.

Nemeth Z, Csizmadia E, Vikstrom L, Li M, Bisht K, Feizi A, Otterbein S, Zuckerbraun B, Costa DB, Pandolfi PP, Fillinger J, Döme B, Otterbein LE, Wegiel B
Oncotarget 2016 Apr 26;7(17):23919-32

---

TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production.

Wang J, Lu R, Yang J, Li H, He Z, Jing N, Wang X, Wang Y
Nature communications 2015 Nov 19;6:8876

---

Neuropathological and biochemical assessments of an Alzheimer's disease patient treated with the γ-secretase inhibitor semagacestat.

Roher AE, Maarouf CL, Kokjohn TA, Whiteside CM, Kalback WM, Serrano G, Belden C, Liebsack C, Jacobson SA, Sabbagh MN, Beach TG
American journal of neurodegenerative disease 2014;3(3):115-33

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Notch1 promotes hepatitis B virus X protein-induced hepatocarcinogenesis via Wnt/β-catenin pathway.

Sun Q, Wang R, Luo J, Wang P, Xiong S, Liu M, Cheng B
International journal of oncology 2014 Oct;45(4):1638-48

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The Notch1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of mouse Notch1. This antibody recognizes human antigen. The Notch1 antibody has been validated for the following applications: ELISA, WB analysis.

Appendix

10062-2-AP.pdf

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