RA0530

antibody from Oursmab

Targeting: NOTCH1 TAN1

Western blot (Supportive data in Antibodypedia)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0530

Provider

Oursmab

Product name

Brontictuzumab (Biosimilar Reference Antibody) (NOTCH1)

Antibody type

Monoclonal

Description

Brontictuzumab (also known as OMP-52M51) is an investigational human monoclonal antibody that was developed as a potential cancer therapy. It functions as a Notch1 inhibitor, designed to block a signaling pathway crucial for the growth and survival of certain cancer cells, particularly cancer stem cells. Clinical trials were conducted to evaluate its efficacy and safety in patients with advanced solid tumors, including colorectal cancer. However, its development appears to have been discontinued, as no significant progress or approvals have been reported in recent years following early-phase studies.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Brontictuzumab (Biosimilar Reference Antibody) (NOTCH1)-RA0530-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.