Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations [0]
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- Product number
- BMS152 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- IL-12 p35 Monoclonal Antibody (B-T21 (BT21)), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: BMS152 (B-T21) recognizes natural and recombinant human IL-12A p35/p70 but not IL-12-p40. BMS 152 blocks IL-12 induced proliferation on PHA and IL-2 activated lymphoblasts. Biologically active IL-12 is a disulfide-linked heterodimeric 70-kDa cytokine composed of a 35-kDa (p35) and a 40-kDa (p40) subunit. p35, a member of the IL-6 superfamily, is secreted in response to IFN gamma and agonists of TLR3, 4, or 7. However, p35 expression has been shown to be inhibited by Th2 cytokines and expressed at much lower levels than p40. Expression of p40 is regulated independently of p35. Moreover, p40 has been shown to be secreted as either a monomer or homodimer. Although each subunit alone does not possess IL-12 bioactivity, the p40 homodimer can bind to the IL-12 receptor and act as an antagonist to IL-12 p70. The receptor for this cytokine is composed of two subunits, IL-12R beta 1 and IL-12R beta 2, the latter of which is the signaling component of the receptor. Applications Tested: Functional Studies (Blocking).
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- B-T21 (BT21)
- Vial size
- 100 µg
- Concentration
- 1 mg/mL
- Storage
- 4° C
Submitted references Slit2 May Underlie Divergent Induction by Thyrotropin of IL-23 and IL-12 in Human Fibrocytes.
Recognition of microbial viability via TLR8 drives T(FH) cell differentiation and vaccine responses.
Fernando R, Atkins SJ, Smith TJ
Journal of immunology (Baltimore, Md. : 1950) 2020 Apr 1;204(7):1724-1735
Journal of immunology (Baltimore, Md. : 1950) 2020 Apr 1;204(7):1724-1735
Recognition of microbial viability via TLR8 drives T(FH) cell differentiation and vaccine responses.
Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schäfer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich N, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Müller M, Jungersen G, Schumann RR, Suttorp N, Sander LE
Nature immunology 2018 Apr;19(4):386-396
Nature immunology 2018 Apr;19(4):386-396
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