Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations [0]
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- Product number
- MAB1570 - Provider product page
- Provider
- R&D Systems
- Product name
- Anti-Human/Mouse IL-12/IL-35 p35 Monoclonal Antibody (Clone 27537)
- Antibody type
- Monoclonal
- Antigen
- S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL‑12/IL-35 p35, Arg23-Ser219
- Description
- Protein A or G purified from ascites
- Reactivity
- Human, Mouse
- Host
- Mouse
- Antigen sequence
P29459
- Isotype
- IgG
- Vial size
- 500 µg
Submitted references Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7.
Gene Expression and Antiviral Activity of Interleukin-35 in Response to Influenza A Virus Infection.
Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1.
Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.
Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo.
Oral Escherichia coli colonization factor antigen I fimbriae ameliorate arthritis via IL-35, not IL-27.
Human prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade.
Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC.
Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma.
Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells.
Human tumor membrane vesicles modified to express glycolipid-anchored IL-12 by protein transfer induce T cell proliferation in vitro: a potential approach for local delivery of cytokines during vaccination.
Halpert MM, Konduri V, Liang D, Chen Y, Wing JB, Paust S, Levitt JM, Decker WK
Stem cells and development 2016 May 15;25(10):774-87
Stem cells and development 2016 May 15;25(10):774-87
Gene Expression and Antiviral Activity of Interleukin-35 in Response to Influenza A Virus Infection.
Wang L, Zhu S, Xu G, Feng J, Han T, Zhao F, She YL, Liu S, Ye L, Zhu Y
The Journal of biological chemistry 2016 Aug 5;291(32):16863-76
The Journal of biological chemistry 2016 Aug 5;291(32):16863-76
Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1.
Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang R, Chu Y, Yang R
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 3;112(9):E957-65
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 3;112(9):E957-65
Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.
Rossetti M, Spreafico R, Saidin S, Chua C, Moshref M, Leong JY, Tan YK, Thumboo J, van Loosdregt J, Albani S
Journal of immunology (Baltimore, Md. : 1950) 2015 Jan 1;194(1):113-24
Journal of immunology (Baltimore, Md. : 1950) 2015 Jan 1;194(1):113-24
Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo.
Hsiao HW, Hsu TS, Liu WH, Hsieh WC, Chou TF, Wu YJ, Jiang ST, Lai MZ
Nature communications 2015 Feb 19;6:6353
Nature communications 2015 Feb 19;6:6353
Oral Escherichia coli colonization factor antigen I fimbriae ameliorate arthritis via IL-35, not IL-27.
Kochetkova I, Thornburg T, Callis G, Holderness K, Maddaloni M, Pascual DW
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 15;192(2):804-16
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 15;192(2):804-16
Human prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade.
Olson BM, Jankowska-Gan E, Becker JT, Vignali DA, Burlingham WJ, McNeel DG
Journal of immunology (Baltimore, Md. : 1950) 2012 Dec 15;189(12):5590-601
Journal of immunology (Baltimore, Md. : 1950) 2012 Dec 15;189(12):5590-601
Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC.
Seyerl M, Kirchberger S, Majdic O, Seipelt J, Jindra C, Schrauf C, Stöckl J
European journal of immunology 2010 Feb;40(2):321-9
European journal of immunology 2010 Feb;40(2):321-9
Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma.
Maneechotesuwan K, Wamanuttajinda V, Kasetsinsombat K, Huabprasert S, Yaikwawong M, Barnes PJ, Wongkajornsilp A
The Journal of allergy and clinical immunology 2009 Jan;123(1):239-48
The Journal of allergy and clinical immunology 2009 Jan;123(1):239-48
Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells.
Liu TY, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, Ishihara O, Matsushita S
European journal of immunology 2008 Apr;38(4):1012-23
European journal of immunology 2008 Apr;38(4):1012-23
Human tumor membrane vesicles modified to express glycolipid-anchored IL-12 by protein transfer induce T cell proliferation in vitro: a potential approach for local delivery of cytokines during vaccination.
Nagarajan S, Selvaraj P
Vaccine 2006 Mar 20;24(13):2264-74
Vaccine 2006 Mar 20;24(13):2264-74
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