13224-1-AP

antibody from Proteintech Group

Targeting: LRG1 LRG

Provider product page for 13224-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [42]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 13224-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13224-1-AP, RRID:AB_2138714
Product name: LRG1 antibody
Antibody type: Polyclonal
Description: KD/KO validated LRG1 antibody (Cat. #13224-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

LRG1 protein structure - 13224-1-AP shown in red.

Submitted references Intermittent fasting ameliorates MAFLD by downregulating Lrg1: insights from bulk RNA sequencing and functional verification.

Chen H, Zhang S, Xie W, Shen J, Liang H
Frontiers in endocrinology 2026;17:1754251

HBO-PC Reprograms Neuroimmune Metabolism Through Disruption of the LRG1-HIF-1α-IL-6-STAT3 Amplification Loop Attenuates Pyroptosis and Ischemia-Reperfusion Injury.

Lv W, Lv J, Xiong K, Yuan S, Yang J, Guo D
CNS neuroscience & therapeutics 2026 May;32(5):e70907

Comprehensive transcriptomic analysis identifies Lrg1 as a potential therapeutic target for preventing muscle atrophy in cancer cachexia.

Lee H, Kim A, Son K, Choi A, Cha S, Shin H, Kim NS, Lee H
American journal of physiology. Cell physiology 2026 Jan 1;330(1):C184-C200

Lysosome-targeted degradation of leucine-rich alpha-2 glycoprotein 1 enables chemosensitization to 5-fluorouracil in colorectal cancer.

Wu G, Zhang K, Min H, Du L, Li J, Li W, Zhang Y, Du S, Qi Y, Zhang W
Journal of controlled release : official journal of the Controlled Release Society 2026 Apr 28;395:114962

LRG1 inhibition promotes acute pancreatitis recovery by inducing cholecystokinin Type 1 receptor expression via Akt.

Lim ST, Zhao X, Liu S, Zhang W, Tan Y, Mullappilly N, Swain SM, Leong ML, Rajarethinam R, Wan KF, Ruedl C, Liddle RA, Li L, Wang X
Theranostics 2025;15(10):4247-4269

Leucine-rich α-2-glycoprotein 1 initiates the onset of diabetic retinopathy in mice.

De Rossi G, Qiu AW, Berg M, Burgoyne T, Martello A, Da Vitoria Lobo ME, Rizzi M, Mueller S, Blackburn J, Meng Y, Walker-Samuel S, Shipley R, Chu CJ, Sivaprasad S, Greenwood J, Moss SE
Science translational medicine 2025 Oct 22;17(821):eadn6047

Shenqi compound ameliorates renal fibrosis in diabetic kidney disease by inhibiting LRG1/TGF-β/Smad signaling pathway.

Yuan Y, Liu L, Chen N, Tang S, Qi Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157355

PROTAC based targeted degradation of LRG1 for mitigating corneal neovascularization.

Zhang J, Qi Y, Li Y, Zhu F, Geng Y, Li Y, Xue B, Bi H, Jiao Y, Min H, Jiang D, Nie G, Qi Y
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113567

Leucine-rich alpha-2-glycoprotein 1 deficiency suppresses ischemia-reperfusion injury-induced renal fibrosis.

Okami N, Wakui H, Azushima K, Miyazawa T, Kubo E, Tsukamoto S, Sotozawa M, Taguchi S, Urate S, Ishiga K, Kinguchi S, Kanaoka T, Tamura K
Scientific reports 2025 Jan 8;15(1):1259

Knockdown of Leucine-rich alpha-2-glycoprotein 1 alleviates renal ischemia-reperfusion injury by inhibiting NOX4-mediated apoptosis, inflammation, and oxidative stress.

Ye J, Qiu C, Zhang L
Experimental cell research 2025 Jan 1;444(1):114341

Gut commensal Alistipes as a potential pathogenic factor in colorectal cancer.

Fu J, Li G, Li X, Song S, Cheng L, Rui B, Jiang L
Discover oncology 2024 Sep 27;15(1):473

Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.

Chen J, Zhang Z, Feng L, Liu W, Wang X, Chen H, Zou H
Archives of biochemistry and biophysics 2024 Mar;753:109892

LRG1 Accelerates Wound Healing in Diabetic Rats by Promoting Angiogenesis via the Wnt/β-Catenin Signaling Pathway.

Yang P, Li S, Zhang H, Ding X, Tan Q
The international journal of lower extremity wounds 2024 Dec;23(4):568-576

Fructose overconsumption accelerates renal dysfunction with aberrant glomerular endothelial-mesangial cell interactions in db/db mice.

Tsuruta H, Yasuda-Yamahara M, Yoshibayashi M, Kuwagata S, Yamahara K, Tanaka-Sasaki Y, Chin-Kanasaki M, Matsumoto S, Ema M, Kume S
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167074

Increased level of serum leucine-rich-alpha-2-glycoprotein 1 in patients with clear cell renal cell carcinoma.

Nakanishi S, Goya M, Suda T, Yonamine T, Sugawa A, Saito S
BMC urology 2024 Apr 24;24(1):94

Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells.

Ruan Z, Cao G, Qian Y, Fu L, Hu J, Xu T, Wu Y, Lv Y
Journal of neuroinflammation 2023 Nov 30;20(1):285

LRG1 Is Involved in the Progression of Ovarian Cancer via Modulating FAK/AKT Signaling Pathway.

Wu D, Xie W, Chen X, Sun H
Frontiers in bioscience (Landmark edition) 2023 May 25;28(5):101

Expression of LRG-1 in mice with hypertensive renal damage and its significance.

Zhang L, Xiao X, Hu X, Wang W, Peng L, Tang R
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2023 Jun 28;48(6):837-845

Serum leucine-rich α2-glycoprotein as a possible marker for inflammatory status in endometriosis.

Kobayashi M, Nakamura O, Kitahara Y, Inoue N, Tsukui Y, Hasegawa Y, Hiraishi H, Yabuki A, Muraoka A, Osuka S, Iwase A
Reproductive medicine and biology 2023 Jan-Dec;22(1):e12536

LRG1 Promotes ECM Integrity by Activating the TGF-β Signaling Pathway in Fibroblasts.

Park HN, Song MJ, Choi YE, Lee DH, Chung JH, Lee ST
International journal of molecular sciences 2023 Aug 4;24(15)

Metformin accelerates bone fracture healing by promoting type H vessel formation through inhibition of YAP1/TAZ expression.

Ruan Z, Yin H, Wan TF, Lin ZR, Zhao SS, Long HT, Long C, Li ZH, Liu YQ, Luo H, Cheng L, Chen C, Zeng M, Lin ZY, Zhao RB, Chen CY, Wang ZX, Liu ZZ, Cao J, Wang YY, Jin L, Liu YW, Zhu GQ, Zou JT, Gong JS, Luo Y, Hu Y, Zhu Y, Xie H
Bone research 2023 Aug 16;11(1):45

Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway.

Dritsoula A, Dowsett L, Pilotti C, O'Connor MN, Moss SE, Greenwood J
Scientific reports 2022 Mar 22;12(1):4867

Highly Sensitive Exosome Detection for Early Diagnosis of Pancreatic Cancer Using Immunoassay Based on Hierarchical Surface-Enhanced Raman Scattering Substrate.

Li J, Li Y, Chen S, Duan W, Kong X, Wang Y, Zhou L, Li P, Zhang C, Du L, Wang C
Small methods 2022 Jun;6(6):e2200154

LRG1: an emerging player in disease pathogenesis.

Camilli C, Hoeh AE, De Rossi G, Moss SE, Greenwood J
Journal of biomedical science 2022 Jan 21;29(1):6

Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor.

Pang KT, Ghim M, Liu C, Tay HM, Fhu CW, Chia RN, Qiu B, Sarathchandra P, Chester AH, Yacoub MH, Wilkinson FL, Weston R, Warboys CM, Hou HW, Weinberg PD, Wang X
Frontiers in cell and developmental biology 2021;9:706143

Prognostic Value of LRG1 in Breast Cancer: A Retrospective Study.

Zhang YS, Han L, Yang C, Liu YJ, Zhang XM
Oncology research and treatment 2021;44(1-2):36-42

LRG1 facilitates corneal fibrotic response by inducing neutrophil chemotaxis via Stat3 signaling in alkali-burned mouse corneas.

Yu B, Yang L, Song S, Li W, Wang H, Cheng J
American journal of physiology. Cell physiology 2021 Sep 1;321(3):C415-C428

LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency.

O'Connor MN, Kallenberg DM, Camilli C, Pilotti C, Dritsoula A, Jackstadt R, Bowers CE, Watson HA, Alatsatianos M, Ohme J, Dowsett L, George J, Blackburn JWD, Wang X, Singhal M, Augustin HG, Ager A, Sansom OJ, Moss SE, Greenwood J
Med (New York, N.Y.) 2021 Nov 12;2(11):1231-1252.e10

LRG1 Promotes Metastatic Dissemination of Melanoma through Regulating EGFR/STAT3 Signalling.

Kwan YP, Teo MHY, Lim JCW, Tan MS, Rosellinny G, Wahli W, Wang X
Cancers 2021 Jun 30;13(13)

Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection.

Ryan AF, Nasamran CA, Pak K, Draf C, Fisch KM, Webster N, Kurabi A
Frontiers in genetics 2020;11:358

A Multifunctional Role of Leucine-Rich α-2-Glycoprotein 1 in Cutaneous Wound Healing Under Normal and Diabetic Conditions.

Liu C, Teo MHY, Pek SLT, Wu X, Leong ML, Tay HM, Hou HW, Ruedl C, Moss SE, Greenwood J, Tavintharan S, Hong W, Wang X
Diabetes 2020 Nov;69(11):2467-2480

MicroRNA-497 elevation or LRG1 knockdown promotes osteoblast proliferation and collagen synthesis in osteoporosis via TGF-β1/Smads signalling pathway.

Gu Z, Xie D, Huang C, Ding R, Zhang R, Li Q, Lin C, Qiu Y
Journal of cellular and molecular medicine 2020 Nov;24(21):12619-12632

Retinal endothelial cell phenotypic modifications during experimental autoimmune uveitis: a transcriptomic approach.

Lipski DA, Foucart V, Dewispelaere R, Caspers LE, Defrance M, Bruyns C, Willermain F
BMC ophthalmology 2020 Mar 17;20(1):106

Leucine-rich α2-glycoprotein-1 upregulation in plasma and kidney of patients with lupus nephritis.

Yang Y, Luo R, Cheng Y, Liu T, Dai W, Li Y, Ge S, Xu G
BMC nephrology 2020 Apr 6;21(1):122

Serum proteomics analysis based on label-free revealed the protective effect of Chinese herbal formula Gu-Ben-Fang-Xiao.

Xing QQ, Liu LW, Zhao X, Lu Y, Dong YM, Liang ZQ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Nov;119:109390

Molecular Beacon Gold Nanosensors for Leucine-Rich Alpha-2-Glycoprotein-1 Detection in Pathological Angiogenesis.

Lio DCS, Liu C, Wiraja C, Qiu B, Fhu CW, Wang X, Xu C
ACS sensors 2018 Sep 28;3(9):1647-1655

Gene expression profiles of glomerular endothelial cells support their role in the glomerulopathy of diabetic mice.

Fu J, Wei C, Zhang W, Schlondorff D, Wu J, Cai M, He W, Baron MH, Chuang PY, Liu Z, He JC, Lee K
Kidney international 2018 Aug;94(2):326-345

LRG1 suppresses the migration and invasion of hepatocellular carcinoma cells.

Zhang Y, Luo Q, Wang N, Hu F, Jin H, Ge T, Wang C, Qin W
Medical oncology (Northwood, London, England) 2015 May;32(5):146

Leucine-rich α-2-glycoprotein promotes TGFβ1-mediated growth suppression in the Lewis lung carcinoma cell lines.

Takemoto N, Serada S, Fujimoto M, Honda H, Ohkawara T, Takahashi T, Nomura S, Inohara H, Naka T
Oncotarget 2015 May 10;6(13):11009-22

Clinicopathological Significance of Leucine-Rich α2-Glycoprotein-1 in Sera of Patients With Pancreatic Cancer.

Furukawa K, Kawamoto K, Eguchi H, Tanemura M, Tanida T, Tomimaru Y, Akita H, Hama N, Wada H, Kobayashi S, Nonaka Y, Takamatsu S, Shinzaki S, Kumada T, Satomura S, Ito T, Serada S, Naka T, Mori M, Doki Y, Miyoshi E, Nagano H
Pancreas 2015 Jan;44(1):93-8

Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis.

Serada S, Fujimoto M, Terabe F, Iijima H, Shinzaki S, Matsuzaki S, Ohkawara T, Nezu R, Nakajima S, Kobayashi T, Plevy SE, Takehara T, Naka T
Inflammatory bowel diseases 2012 Nov;18(11):2169-79

A combination of serum leucine-rich α-2-glycoprotein 1, CA19-9 and interleukin-6 differentiate biliary tract cancer from benign biliary strictures.

Sandanayake NS, Sinclair J, Andreola F, Chapman MH, Xue A, Webster GJ, Clarkson A, Gill A, Norton ID, Smith RC, Timms JF, Pereira SP
British journal of cancer 2011 Oct 25;105(9):1370-8

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 13224-1-AP(LRG1 antibody) at dilution of 1:400
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The LRG1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LRG1. This antibody recognizes human, mouse antigen. The LRG1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 13224-1-AP.pdf

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