HPA001888

antibody from Atlas Antibodies

Targeting: LRG1 LRG

Provider product page for HPA001888

Western blot

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [16]
Comments [0]
Validations
Immunohistochemistry [1]

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Product number: HPA001888 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA001888, RRID:AB_1079276
Product name: Anti-LRG1
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human LRG1, Gene description: leucine-rich alpha-2-glycoprotein 1, Alternative Gene Names: LRG, Validated applications: IHC, WB, Uniprot ID: P02750, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.2 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

LRG1 protein structure - HPA001888 shown in red.

Submitted references LRG1 and SDR16C5 protein expressions differ according to HPV status in oropharyngeal squamous cell carcinoma.

Randén-Brady R, Carpén T, Hautala LC, Tolvanen T, Haglund C, Joenväärä S, Mattila P, Mäkitie A, Lehtonen S, Hagström J, Silén S
Scientific reports 2024 Jun 19;14(1):14148

Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation

Yang J, Yin G, Kim D, Han A, Lee D, Min K, Fu Y, Yun J, Suh J, Ryu J, Kim H
Experimental & Molecular Medicine 2023;55(5):1013-1022

Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function

Yin G, Kim D, Kang J, Im Y, Lee D, Han A, Ock J, Choi M, Kwon M, Limanjaya A, Jung S, Yang J, Min K, Yun J, Koh Y, Park J, Hwang D, Suh J, Ryu J, Kim H
Experimental & Molecular Medicine 2022;54(5):626-638

LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation

Choi C, Barr W, Zaman S, Model C, Park A, Koenen M, Lin Z, Szwed S, Marchildon F, Crane A, Carroll T, Molina H, Cohen P
eLife 2022;11

Novel Blood Vascular Endothelial Subtype-Specific Markers in Human Skin Unearthed by Single-Cell Transcriptomic Profiling.

He Y, Tacconi C, Dieterich LC, Kim J, Restivo G, Gousopoulos E, Lindenblatt N, Levesque MP, Claassen M, Detmar M
Cells 2022 Mar 25;11(7)

LRG1 Expression Is Elevated in the Eyes of Patients with Neovascular Age-Related Macular Degeneration

Mundo L, Tosi G, Lazzi S, Pertile G, Parolini B, Neri G, Posarelli M, De Benedetto E, Bacci T, Silvestri E, Siciliano M, Barbera S, Orlandini M, Greenwood J, Moss S, Galvagni F
International Journal of Molecular Sciences 2021;22(16):8879

Evaluation of leucine-rich alpha-2 glycoprotein as a biomarker of fetal infection.

Kajimoto E, Endo M, Fujimoto M, Matsuzaki S, Fujii M, Yagi K, Kakigano A, Mimura K, Tomimatsu T, Serada S, Takeuchi M, Yoshino K, Ueda Y, Kimura T, Naka T
PloS one 2020;15(11):e0242076

Leucine-rich alpha 2 glycoprotein is a new marker for active disease of tuberculosis.

Fujimoto M, Matsumoto T, Serada S, Tsujimura Y, Hashimoto S, Yasutomi Y, Naka T
Scientific reports 2020 Feb 25;10(1):3384

A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection

Månberg A, Bradley F, Qundos U, Guthrie B, Birse K, Noël-Romas L, Lindskog C, Bosire R, Kiarie J, Farquhar C, Burgener A, Nilsson P, Broliden K
Molecular & Cellular Proteomics 2019;18(3):461-476

Leucine-rich alpha-2-glycoprotein-1 is up-regulated in colorectal cancer and is a tumor promoter

Zhang Q, Huang R, Tang Q, Yu Y, Huang Q, Chen Y, Wang G, Wang X
OncoTargets and Therapy 2018;Volume 11

LRG1 promotes proliferation and inhibits apoptosis in colorectal cancer cells via RUNX1 activation

Ahmad A, Zhou Y, Zhang X, Zhang J, Fang J, Ge Z, Li X
PLOS ONE 2017;12(4):e0175122

Overexpression of leucine-rich α2-glycoprotein-1 is a prognostic marker and enhances tumor migration in gastric cancer.

Yamamoto M, Takahashi T, Serada S, Sugase T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Naka T, Mori M, Doki Y
Cancer science 2017 Oct;108(10):2052-2060

Sputum Leucine-Rich Alpha-2 Glycoprotein as a Marker of Airway Inflammation in Asthma.

Honda H, Fujimoto M, Miyamoto S, Ishikawa N, Serada S, Hattori N, Nomura S, Kohno N, Yokoyama A, Naka T
PloS one 2016;11(9):e0162672

Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease.

Khoonsari PE, Häggmark A, Lönnberg M, Mikus M, Kilander L, Lannfelt L, Bergquist J, Ingelsson M, Nilsson P, Kultima K, Shevchenko G
PloS one 2016;11(3):e0150672

LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling

Wang X, Abraham S, McKenzie J, Jeffs N, Swire M, Tripathi V, Luhmann U, Lange C, Zhai Z, Arthur H, Bainbridge J, Moss S, Greenwood J
Nature 2013;499(7458):306-311

Tumour expression of bladder cancer‐associated urinary proteins

Lindén M, Segersten U, Runeson M, Wester K, Busch C, Pettersson U, Lind S, Malmström P
BJU International 2013;112(3):407-415

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human liver and cerebral cortex tissues using HPA001888 antibody. Corresponding LRG1 RNA-seq data are presented for the same tissues.
Sample type: Human
Protocol: Protocol
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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