APG01121G

A2M antibody from Leading Biology
CPAMD5, FWP007, S863-7
Western blot
Recommended by provider
Immunoprecipitation
Recommended by provider
Immunohistochemistry
Recommended by provider

Antibody data

Product number
APG01121G
Provider
Leading Biology
Product name
A2M / Alpha-2-Macroglobulin Antibody
Provider product page
Leading Biology - APG01121G
Antibody type
Polyclonal
Description
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Reactivity
Human
Host
Goat
Storage
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Provider Type Product Number
- No reagents -